pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MAST3   
Synonyms -
Description microtubule associated serine/threonine kinase 3
Transcript NM_015016   
Expression
Putative miRNA Targets on MAST3
3'UTR of MAST3
(miRNA target sites are highlighted)
>MAST3|NM_015016|3'UTR
   1 TCCCCTGCCAGGTCTCTCCCTGGCATCAAAGTTACGCGTTTTCTTGTGCAATGTTTTTTCCGTAAAGTCATGCCTGGATG
  81 GGGACTGAGCCACCAGCCTGACACCCAGAAGGCGAGAAGCCATCTCGGTCCTTGCTGGAAGGTGGAGACATCGCTTGTGT
 161 TCTGGTGTCAATCGGGGCTGGATGGGGCAAGAATGGGGGACAAGGGTGGCTTTGTAAATAGCAGCAAATCCCTGCAACTA
 241 ATTTATTACTTTTTTTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCGGGCTGGAGTGCAGCGG
 321 CGTGATCTCAGCTCACTGCAACCTCCGCCTCCCAAGTTCAAGCGATTGTCCTGCCTCAGCTTCCCAAGTGGCTGGGATTA
 401 CAGGCGCCCACCACTATGCCCAGCTAATTTTTTGTATTTTTAGTACAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCT
 481 CGAACTCCTGACCTCATGATTTGCCTGCCTTTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGGGCCCAGCCT
 561 AATTTATTACTTTTTATAAGCGATAGCCGTACTGAGCCGCCCCCTGAAGGCGGCTGCCAGGTCTTGCCCCAGGCACCTGG
 641 GACTCTGTTTGCAGGCCCTGCCCTCTGGGCTGAGAAGGATGCACTTTGGACAAGTCATCTGTGTTTGTGTTTTCCAGTTT
 721 TTCTGTACTTTTTAAGTGTTTTGTGTTACCTGGTCTCATTCCCCTCCCCACACCTACCCATTTGAGGGGATGGAGTTGAA
 801 GTCACCTGGTCACCTGTACCGGCCCAGTTCGGCTACAACCTGGAGTGTCCGTAAACAATTCCTCTCACCCACAAAACAAT
 881 GTAATCCCAGCGATGGACTGGATTCTGAAGGCCACTTCCCACCATCATAGCTGCCATGCCCAGGCAGTGCCTGCTCTATA
 961 TATAGAGTCTGCCTCCAATCCTGCTGGCTTCAGCCTGGAGAAGGGATATGGGAGCTGGAGCTTTGATGGATGAATAGGTG
1041 TTCACCGGATCTGGGCAGAGGGGTCATCCGCTCCCCAGGTGGGCACTGATAAAGGAAGGTACAGGCCTCACCTGGAACTG
1121 CCAAGGCAGCCTCCAGAAATGCTCGGCTGTCTCGGGGCACGCTCCAGTATGCCAGTCCTGCGGGATTACGTCCAGCTACT
1201 TCCAGAAACACTCAGTGTCCCCTCCCCTCAGGCTCTGCCTTGGCCTGGCCTTGTCCAGTCTACCCTGGACAAGATGCCGT
1281 GTGTTTGAGGCCCAGCAGAGTAAGCCCTTGGCCGTGATGTGTCTGAAACACCTGTTAGGGGTTCCCTCCATATGTCAGAG
1361 CCTCTCTGGGATGAAGTTCAAGCCAGAAAACCCAGTCGAGGCTCAAGTTTGAATTTCAGCTTCACTGTGTGGCTCTGGGA
1441 AAATGGCTTTCCCACTCTGTGCCTCAGTTTCCTTGTGTTTACAAGACTAATCCCATTGACTGTTTATTAAGCACCTACTG
1521 TGTGCCAAGCGCTTTTACGTGGCTTCTCCCTCAGCCAGCCTTGAGAAGGCTGGAGGTGGTGTCATCACCTCCATTTTACA
1601 GACAAAGCAGCTGAGACCCCAGCGAGGGGCGGAGACCTGTCCCACGATCACCCAGCAGGAGTCGTGGCAGAACGGAGCAT
1681 CAGCCAGACCCTGTTGTGGGCGTTGTCATCAAGGGAGCTTGAATGGAGGGTCTGGTGTCAGATACAGCCGACTCCAGCCC
1761 CAGCTCATCCCCCATGATGCTGTGTGACCCACTGGGCACTCTGGTGAGGGAGCTTTCCAGACATCAACAGCCCACTCTGC
1841 TTCCCTTTCTGAGTCCCCTGTCCAGCACTGCCTAGTGTTGGAGGGTAGACCAAGGCTGTGCATGATTCACCCCCTCCTTC
1921 CATCCTGGAGCTGGCAGTGAATAAAAGCCCGTATTTACAAAGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggucGAUUGUUAUGUGACGGa 5'
               ||: | | :||||||| 
Target 5' gtcccCTGTCCA-GCACTGCCt 3'
1853 - 1873 148.00 -16.40
2
miRNA  3' cgGUCG-AUU---GUUAUGUGACGga 5'
            |:|| |:|   ||:  ||||||  
Target 5' agCGGCGTGATCTCAGCTCACTGCaa 3'
316 - 341 132.00 -14.80
3
miRNA  3' cgGUCGAUUGU-----UAUGUGACGGa 5'
            :||||: ||     | :|| |||| 
Target 5' caTAGCTGCCATGCCCAGGCAGTGCCt 3'
926 - 952 124.00 -15.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30467501 4 COSMIC
COSN30137620 12 COSMIC
COSN20042704 22 COSMIC
COSN8605225 24 COSMIC
COSN18716296 25 COSMIC
COSN7355658 33 COSMIC
COSN30698408 38 COSMIC
COSN30495986 99 COSMIC
COSN28723029 128 COSMIC
COSN20115522 174 COSMIC
COSN6667378 305 COSMIC
COSN26082494 347 COSMIC
COSN8752119 503 COSMIC
COSN20779864 583 COSMIC
COSN1761742 618 COSMIC
COSN29158831 839 COSMIC
COSN7355659 867 COSMIC
COSN9349917 1015 COSMIC
COSN28400190 1531 COSMIC
COSN25038269 1540 COSMIC
COSN22107300 1564 COSMIC
COSN25870548 1702 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1259598855 2 dbSNP
rs749658785 3 dbSNP
rs769063511 4 dbSNP
rs1247921341 6 dbSNP
rs548765858 7 dbSNP
rs1021116355 8 dbSNP
rs183442436 10 dbSNP
rs1405946811 11 dbSNP
rs767536822 14 dbSNP
rs1313323624 16 dbSNP
rs1433317795 17 dbSNP
rs115547955 20 dbSNP
rs1389397138 32 dbSNP
rs753865806 34 dbSNP
rs760791799 36 dbSNP
rs187507492 37 dbSNP
rs751489087 38 dbSNP
rs757249839 39 dbSNP
rs780941831 42 dbSNP
rs1322906367 44 dbSNP
rs1016611874 46 dbSNP
rs1226686681 47 dbSNP
rs745395962 48 dbSNP
rs952492251 52 dbSNP
rs1298625171 54 dbSNP
rs1386479707 60 dbSNP
rs1156510897 62 dbSNP
rs980219851 63 dbSNP
rs1369894937 70 dbSNP
rs1407649689 72 dbSNP
rs758151486 86 dbSNP
rs1335413865 91 dbSNP
rs938297180 98 dbSNP
rs992510309 101 dbSNP
rs1390624205 114 dbSNP
rs913467417 115 dbSNP
rs1340352373 122 dbSNP
rs530842381 127 dbSNP
rs1480002478 128 dbSNP
rs1290539479 133 dbSNP
rs1251733557 143 dbSNP
rs910550578 144 dbSNP
rs570750086 149 dbSNP
rs943354673 151 dbSNP
rs191926951 153 dbSNP
rs1232945022 154 dbSNP
rs1228014754 155 dbSNP
rs893917959 156 dbSNP
rs945431303 166 dbSNP
rs1042614054 172 dbSNP
rs149995015 173 dbSNP
rs946310828 173 dbSNP
rs1360571915 174 dbSNP
rs1464315252 174 dbSNP
rs59523925 174 dbSNP
rs111866808 175 dbSNP
rs1043223644 177 dbSNP
rs548883004 214 dbSNP
rs1471984959 217 dbSNP
rs1201145868 220 dbSNP
rs1033904464 225 dbSNP
rs894818817 232 dbSNP
rs1253132964 238 dbSNP
rs1005155397 240 dbSNP
rs1258001107 250 dbSNP
rs1328755557 250 dbSNP
rs1482456644 250 dbSNP
rs71872759 250 dbSNP
rs757029924 250 dbSNP
rs774995390 250 dbSNP
rs1016539688 251 dbSNP
rs1351059621 254 dbSNP
rs565583170 255 dbSNP
rs11669208 256 dbSNP
rs1440574551 258 dbSNP
rs1187390085 260 dbSNP
rs12975488 260 dbSNP
rs1303197548 260 dbSNP
rs1364908500 260 dbSNP
rs1422571739 260 dbSNP
rs1457263020 260 dbSNP
rs1465697663 260 dbSNP
rs1491445846 260 dbSNP
rs61501122 260 dbSNP
rs746527684 260 dbSNP
rs749533952 260 dbSNP
rs779129815 260 dbSNP
rs1491175360 261 dbSNP
rs911465099 261 dbSNP
rs113975544 262 dbSNP
rs867779136 263 dbSNP
rs1179551159 266 dbSNP
rs1329861931 267 dbSNP
rs1264805572 268 dbSNP
rs1242587795 269 dbSNP
rs1342190650 270 dbSNP
rs1431030583 275 dbSNP
rs1478170246 278 dbSNP
rs1171434699 279 dbSNP
rs1362605938 280 dbSNP
rs1399452333 283 dbSNP
rs1322089011 284 dbSNP
rs1435188988 287 dbSNP
rs1389463926 294 dbSNP
rs1160948061 296 dbSNP
rs1456880345 297 dbSNP
rs552191751 298 dbSNP
rs1246430155 299 dbSNP
rs1190692003 301 dbSNP
rs1310464447 302 dbSNP
rs1266846067 303 dbSNP
rs112170279 305 dbSNP
rs1227429349 311 dbSNP
rs1339724026 313 dbSNP
rs1299531271 316 dbSNP
rs1435453645 319 dbSNP
rs1330121154 320 dbSNP
rs1409656343 322 dbSNP
rs1387957545 323 dbSNP
rs184113540 335 dbSNP
rs1462839288 336 dbSNP
rs1306372336 341 dbSNP
rs1429528482 347 dbSNP
rs1388766698 348 dbSNP
rs904728894 354 dbSNP
rs1475887163 359 dbSNP
rs932172116 364 dbSNP
rs1196870296 365 dbSNP
rs1453357463 369 dbSNP
rs1204279109 375 dbSNP
rs1482031538 376 dbSNP
rs1276562492 380 dbSNP
rs1050909068 381 dbSNP
rs985793559 388 dbSNP
rs755213471 390 dbSNP
rs532977000 391 dbSNP
rs74915827 403 dbSNP
rs780701174 403 dbSNP
rs79142979 403 dbSNP
rs1331124551 406 dbSNP
rs574222593 407 dbSNP
rs1482592330 424 dbSNP
rs1036348708 429 dbSNP
rs141725155 435 dbSNP
rs1269227673 441 dbSNP
rs1451763175 444 dbSNP
rs1197735537 451 dbSNP
rs1479054845 453 dbSNP
rs945483776 455 dbSNP
rs1181515643 463 dbSNP
rs1375427817 480 dbSNP
rs994529278 482 dbSNP
rs1026903868 483 dbSNP
rs1204999013 486 dbSNP
rs756987654 488 dbSNP
rs1276085415 497 dbSNP
rs377641117 508 dbSNP
rs1450860212 509 dbSNP
rs1042458026 512 dbSNP
rs928132565 513 dbSNP
rs952619250 514 dbSNP
rs895426107 518 dbSNP
rs780557886 520 dbSNP
rs1038038358 530 dbSNP
rs1306503735 531 dbSNP
rs1332591452 541 dbSNP
rs1393340965 546 dbSNP
rs1387498614 547 dbSNP
rs1034076313 548 dbSNP
rs1407089835 555 dbSNP
rs959799531 559 dbSNP
rs1329404245 564 dbSNP
rs1437429228 565 dbSNP
rs993884340 574 dbSNP
rs1472419723 583 dbSNP
rs992482371 589 dbSNP
rs556975696 590 dbSNP
rs1206312422 599 dbSNP
rs967620874 599 dbSNP
rs1330515825 600 dbSNP
rs1286967995 601 dbSNP
rs1006747492 602 dbSNP
rs979384497 603 dbSNP
rs576763149 607 dbSNP
rs755482167 613 dbSNP
rs1383844919 621 dbSNP
rs1320060664 624 dbSNP
rs1433008108 629 dbSNP
rs1390997936 633 dbSNP
rs1159921761 635 dbSNP
rs545753171 636 dbSNP
rs911959817 637 dbSNP
rs1164803413 638 dbSNP
rs1465838127 641 dbSNP
rs944824521 642 dbSNP
rs1247033460 644 dbSNP
rs376834958 646 dbSNP
rs572750537 646 dbSNP
rs1465964681 663 dbSNP
rs1242259690 667 dbSNP
rs1220161021 668 dbSNP
rs1449328578 673 dbSNP
rs1451561641 681 dbSNP
rs928049152 684 dbSNP
rs1248635745 692 dbSNP
rs1360543620 702 dbSNP
rs1168954438 704 dbSNP
rs1297305735 704 dbSNP
rs1226553053 707 dbSNP
rs1370559529 721 dbSNP
rs1364313197 729 dbSNP
rs1036316131 734 dbSNP
rs1435788118 740 dbSNP
rs939415733 743 dbSNP
rs1304809098 745 dbSNP
rs1458788030 770 dbSNP
rs1162867408 771 dbSNP
rs1425079936 772 dbSNP
rs568686922 774 dbSNP
rs1166476899 789 dbSNP
rs1388893978 792 dbSNP
rs1419732420 805 dbSNP
rs1190160202 808 dbSNP
rs1487181293 815 dbSNP
rs1245502624 820 dbSNP
rs1225445774 821 dbSNP
rs1055329877 823 dbSNP
rs1459044976 824 dbSNP
rs374125597 828 dbSNP
rs1048759507 831 dbSNP
rs1309504378 832 dbSNP
rs1364555384 835 dbSNP
rs1218719847 842 dbSNP
rs779583055 851 dbSNP
rs1001755888 852 dbSNP
rs1432809695 854 dbSNP
rs1314842241 863 dbSNP
rs896837821 871 dbSNP
rs879562884 878 dbSNP
rs1463296806 880 dbSNP
rs553717613 882 dbSNP
rs1174847041 892 dbSNP
rs1426745578 893 dbSNP
rs1199474097 895 dbSNP
rs959770531 920 dbSNP
rs1481080160 921 dbSNP
rs1014052985 939 dbSNP
rs1251662692 941 dbSNP
rs1180506821 942 dbSNP
rs1481782897 950 dbSNP
rs993769894 951 dbSNP
rs1209750868 952 dbSNP
rs1051183222 956 dbSNP
rs1224149791 957 dbSNP
rs1265119507 957 dbSNP
rs890907813 959 dbSNP
rs1392933327 960 dbSNP
rs1373866098 964 dbSNP
rs1208975641 968 dbSNP
rs1020048619 982 dbSNP
rs1266859358 984 dbSNP
rs967414316 985 dbSNP
rs1407821244 987 dbSNP
rs978466383 999 dbSNP
rs1463212033 1011 dbSNP
rs1456209599 1012 dbSNP
rs1411876205 1018 dbSNP
rs1180208051 1019 dbSNP
rs1421385180 1026 dbSNP
rs1018147076 1035 dbSNP
rs1185274252 1047 dbSNP
rs892935967 1048 dbSNP
rs1245157071 1061 dbSNP
rs566427610 1062 dbSNP
rs1266302338 1068 dbSNP
rs573562525 1070 dbSNP
rs1317416228 1076 dbSNP
rs1311807503 1079 dbSNP
rs1394020395 1091 dbSNP
rs777984274 1091 dbSNP
rs966721691 1091 dbSNP
rs953678990 1099 dbSNP
rs1035422218 1100 dbSNP
rs986696041 1103 dbSNP
rs1416164110 1104 dbSNP
rs772291591 1110 dbSNP
rs773673094 1112 dbSNP
rs1159789273 1116 dbSNP
rs868101944 1121 dbSNP
rs1455841953 1124 dbSNP
rs542468904 1130 dbSNP
rs562262539 1131 dbSNP
rs373851428 1132 dbSNP
rs916753284 1145 dbSNP
rs919355312 1146 dbSNP
rs537622787 1152 dbSNP
rs1464613401 1154 dbSNP
rs1304485279 1155 dbSNP
rs747183894 1161 dbSNP
rs1049082777 1162 dbSNP
rs1264750796 1165 dbSNP
rs974314337 1167 dbSNP
rs1402778954 1168 dbSNP
rs1315450256 1173 dbSNP
rs888347491 1177 dbSNP
rs937309703 1182 dbSNP
rs1055633921 1183 dbSNP
rs895613333 1189 dbSNP
rs1228613665 1190 dbSNP
rs544389910 1191 dbSNP
rs1326434078 1196 dbSNP
rs771251631 1196 dbSNP
rs1020019064 1199 dbSNP
rs1211667166 1200 dbSNP
rs942468822 1207 dbSNP
rs1164578619 1208 dbSNP
rs1039828411 1210 dbSNP
rs1195461575 1214 dbSNP
rs564558296 1214 dbSNP
rs1483832494 1221 dbSNP
rs533194675 1222 dbSNP
rs776625914 1227 dbSNP
rs1490817872 1236 dbSNP
rs73925431 1242 dbSNP
rs765111310 1244 dbSNP
rs1339659860 1254 dbSNP
rs1473811888 1265 dbSNP
rs903133198 1268 dbSNP
rs1330061768 1274 dbSNP
rs986305510 1275 dbSNP
rs1367982852 1278 dbSNP
rs1304157980 1279 dbSNP
rs569397392 1280 dbSNP
rs1394609095 1282 dbSNP
rs1417594246 1286 dbSNP
rs1462672817 1287 dbSNP
rs565674246 1288 dbSNP
rs1197324740 1290 dbSNP
rs1019161367 1292 dbSNP
rs1269448014 1294 dbSNP
rs960955343 1306 dbSNP
rs1178262281 1314 dbSNP
rs990931800 1315 dbSNP
rs1274843638 1316 dbSNP
rs1378288732 1320 dbSNP
rs1196084035 1334 dbSNP
rs528350784 1338 dbSNP
rs1311060433 1339 dbSNP
rs1224765668 1341 dbSNP
rs1372162119 1346 dbSNP
rs1284415035 1351 dbSNP
rs1409611447 1361 dbSNP
rs1334413753 1362 dbSNP
rs1410260374 1371 dbSNP
rs1306990181 1382 dbSNP
rs972223024 1404 dbSNP
rs557288188 1406 dbSNP
rs919315676 1407 dbSNP
rs1410778694 1408 dbSNP
rs930773152 1425 dbSNP
rs1220612416 1428 dbSNP
rs1301278700 1434 dbSNP
rs540013573 1436 dbSNP
rs1470972871 1443 dbSNP
rs1429924613 1465 dbSNP
rs188403276 1473 dbSNP
rs1311173291 1481 dbSNP
rs1468531654 1486 dbSNP
rs1233147926 1491 dbSNP
rs962748991 1494 dbSNP
rs535109938 1495 dbSNP
rs775439050 1501 dbSNP
rs918747609 1507 dbSNP
rs930282318 1513 dbSNP
rs1323545629 1515 dbSNP
rs1266920780 1518 dbSNP
rs987420109 1531 dbSNP
rs1349119036 1532 dbSNP
rs912239188 1533 dbSNP
rs1443322787 1536 dbSNP
rs926685483 1539 dbSNP
rs537199550 1540 dbSNP
rs1334883663 1551 dbSNP
rs942332898 1555 dbSNP
rs1193140526 1559 dbSNP
rs1268136072 1560 dbSNP
rs556798519 1561 dbSNP
rs1398931523 1562 dbSNP
rs570493074 1569 dbSNP
rs938013712 1572 dbSNP
rs539096221 1573 dbSNP
rs1055687052 1574 dbSNP
rs1472306645 1581 dbSNP
rs1171657420 1582 dbSNP
rs1391993604 1590 dbSNP
rs1430365056 1593 dbSNP
rs1461484849 1598 dbSNP
rs1246920172 1606 dbSNP
rs1213003650 1616 dbSNP
rs762990494 1619 dbSNP
rs552981211 1621 dbSNP
rs763777943 1624 dbSNP
rs570884953 1625 dbSNP
rs370884688 1631 dbSNP
rs866609804 1632 dbSNP
rs1041599366 1645 dbSNP
rs751433114 1646 dbSNP
rs999986284 1647 dbSNP
rs1366262818 1658 dbSNP
rs1438137409 1659 dbSNP
rs1299216240 1660 dbSNP
rs1344880848 1661 dbSNP
rs1383771716 1662 dbSNP
rs1229800464 1663 dbSNP
rs573625552 1669 dbSNP
rs375811930 1674 dbSNP
rs888751996 1680 dbSNP
rs1224026973 1684 dbSNP
rs556057257 1686 dbSNP
rs1007190462 1687 dbSNP
rs1363554486 1693 dbSNP
rs1165200478 1694 dbSNP
rs867332129 1695 dbSNP
rs1019131546 1702 dbSNP
rs192415087 1703 dbSNP
rs1389117172 1707 dbSNP
rs966290228 1709 dbSNP
rs1002797810 1713 dbSNP
rs557574242 1716 dbSNP
rs184302360 1719 dbSNP
rs1012685096 1731 dbSNP
rs1225124085 1735 dbSNP
rs544765129 1744 dbSNP
rs564441379 1747 dbSNP
rs952226500 1751 dbSNP
rs984854183 1773 dbSNP
rs1364246940 1774 dbSNP
rs1025770553 1779 dbSNP
rs1404295265 1780 dbSNP
rs1343537613 1789 dbSNP
rs1417112884 1792 dbSNP
rs1425016230 1802 dbSNP
rs1406926046 1806 dbSNP
rs951597696 1811 dbSNP
rs564843319 1819 dbSNP
rs1348902960 1820 dbSNP
rs533453762 1825 dbSNP
rs58695150 1836 dbSNP
rs1419661978 1845 dbSNP
rs1190102734 1846 dbSNP
rs1480410393 1846 dbSNP
rs1058842 1850 dbSNP
rs964311216 1857 dbSNP
rs1202051089 1863 dbSNP
rs1490600318 1884 dbSNP
rs150555522 1885 dbSNP
rs1202771616 1896 dbSNP
rs1273860350 1897 dbSNP
rs959331965 1897 dbSNP
rs539549651 1906 dbSNP
rs992181554 1910 dbSNP
rs1222926690 1914 dbSNP
rs917155890 1922 dbSNP
rs1365294777 1924 dbSNP
rs529207384 1938 dbSNP
rs1285039779 1947 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BACD1
Disease MIMAT0003327
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020024. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020024
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD1 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000262811.6 | 3UTR | GCCUAGUGUUGGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.621 6.0e-4 0.689 9.8e-5 24 Click to see details
GSE19783 ER+ ER+ breast cancer 0.512 1.1e-2 0.319 8.5e-2 20 Click to see details
GSE28260 Renal cortex and medulla -0.624 1.1e-2 -0.577 1.9e-2 13 Click to see details
GSE19536 Breast cancer 0.226 1.2e-2 0.257 4.9e-3 100 Click to see details
GSE32688 Pancreatic cancer 0.384 1.5e-2 0.406 1.1e-2 32 Click to see details
GSE17498 Multiple myeloma 0.217 8.9e-2 0.074 3.2e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.272 1.0e-1 0.374 3.9e-2 23 Click to see details
GSE19783 ER- ER- breast cancer 0.141 1.1e-1 0.232 2.0e-2 79 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.255 1.1e-1 0.098 3.2e-1 25 Click to see details
GSE38226 Liver fibrosis 0.276 1.1e-1 0.003 4.9e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.227 1.4e-1 -0.152 2.3e-1 25 Click to see details
GSE14794 Lymphoblastoid cells 0.088 2.0e-1 0.011 4.6e-1 90 Click to see details
GSE26953 Aortic valvular endothelial cells -0.174 2.1e-1 -0.187 1.9e-1 24 Click to see details
GSE19350 CNS germ cell tumors -0.248 2.2e-1 -0.014 4.8e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.101 3.4e-1 0.429 3.0e-2 20 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.14 3.7e-1 0.024 4.8e-1 8 Click to see details
GSE21687 Ependynoma primary tumors 0.032 4.0e-1 0.061 3.2e-1 64 Click to see details
GSE17306 Multiple myeloma 0.01 4.7e-1 0.308 1.6e-2 49 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.706 0.15 0.400 0.3 4 Click to see details
THCA -0.83 0.19 -0.500 0.33 3 Click to see details
LUSC -0.197 0.4 0.000 0.5 4 Click to see details
UCEC 0.012 0.49 -0.024 0.48 8 Click to see details
UCEC 0.012 0.49 -0.024 0.48 8 Click to see details
UCEC 0.012 0.49 -0.024 0.48 8 Click to see details
UCEC 0.012 0.49 -0.024 0.48 8 Click to see details
UCEC 0.012 0.49 -0.024 0.48 8 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission