miRTarBase - #MIRT496554


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pre-miRNA Information
pre-miRNA hsa-mir-4301   
Genomic Coordinates chr11: 113450023 - 113450088
Description Homo sapiens miR-4301 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4301
Sequence 11| UCCCACUACUUCACUUGUGA |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs184176277 2 dbSNP
rs1191324913 13 dbSNP
rs1369198005 15 dbSNP
rs1036973189 16 dbSNP
rs944900541 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TBX15   
Synonyms TBX14
Description T-box 15
Transcript NM_152380   
Expression
Putative miRNA Targets on TBX15
3'UTR of TBX15
(miRNA target sites are highlighted)		 
>TBX15|NM_152380|3'UTR
   1 AGGCCAGTCCAAACACCACGGAGCATTTGGCAATCAAGGCCCCAGAGTCTCCGTGGTCAGATCCTCCTCTTTGGGAGTCC
  81 AGTGTCTTTGAAAAACAGGAACCGTGTTTTTTTTTTTTTTTTTTTTCTGGCCGAAGACATATACCCAAGAACAAGAGATA
 161 CCTTTAAGCCAGTGAAGGATACTTGCGATAGAATCATCCGCAACTCAGTGGCCATTCTTCTGCCTTCCCAGACCTTAGTT
 241 TTATAAAGCATTGTCTGTTCCAGAGTGGCCTTTGAAGAGACTGAATAATCACTTCGTCATAATGTTAAGGGAGATGCTAG
 321 TGTGTGGCAGCCATGAAAAGTTACACATACACACCCACATACAGACAGACCTACCTATACATACGTGCACACACACATAC
 401 ATATTCATACACAATTCATACACATGCAATCATACATGCACACTGACTCTGAACTGGGTGAACTCTGTGGAGGGAGGCCC
 481 AGAATGGGTGCTTTCACCAAGAATTTGTCTGTGTACAACTCTAGATGGAGTGGGCCAGCAGTAGCTGCCAGTCTTTCTCC
 561 CCTGCAGCTTCCTCTGCTTCTGGAATGAACCATGTATCCTGGAGACCCTCCCAATGGATGAGAGTGGAAAGACATCAGTA
 641 CAACTGGACTTGGCTTCCGGAAAAAGATTGCTTTTGAACTTTGGCTCTCTTCACTTGTATGCTATCATTGATATTCCCAG
 721 TGGTGCCCGTGGAAAGAGGGAGAAAGAGAAGCTGAACAGGAGAAAGACAAACAGAAAGAATAGAGAACAGGAACGAGGTG
 801 GAGAGCAAGACTGACAGAGAAAGTGTGAGCAATGATGAGAATTTTAATTCACCAAGGAGACGTGTTTTTGGTTTGTCCCC
 881 CCAAACCCCGCCCGCCCCACTACAGGTTATGGAAAGAATCATGGCATTACTGAGGAGTAAACCTCTCTGGCACACTGAGC
 961 ATGGTCAGGGCATTGGTCAGAGGGACAGAGCAAGGAATGCATCCTGAGCCCACAGCTTTGACCACTGTGATCCAGAAGAG
1041 AGGTGCACTACGTGGGAAGTGCTGATTCCACAGCATGCAGCCTGGTAGGGGAAGGAAAATAAAAGGGTGTGAAGAAGGAA
1121 TAGTTTTATAATCTCGGAAGATGATACCAAGAGCAGAGGCAACAAATAGAGGCCTGGCCTCCAGGTGCCGGATCCAGACA
1201 CCTGACCTAGAATGCCTGCCCGCTATCCCTGTGGCAGGAAATATCCCCTCATGTCCCAGGGAATTGCAGATGGGTCTTCT
1281 ATACCCTTCTACCTGCCCTTAGATCTCCATTTTTATCAAATAGTACATTGCATTTTGAAGTTTTGGGTTTTGTCCTTCAT
1361 CTTTCCCTTTCCCTTCAAATCTTTTAATGGTAAGAAAGCAAGTGAAGCTTGGTGCAAGCTAAAATTTTTAAATGGTGTGG
1441 AAATGCAAATAATACCAAGTAAAATAATACAGATATTATTAAAGTTTCTGGTTTTGAGGTGTTGTAGATAAATGTATTTA
1521 TGTGCCTAGTGGGGAATCCAATATTATGAATATGAAAAAGGGGGCAATAAAAGGGTATGTAAAATATGTATGAAGAAAAG
1601 GTGTACAAAAATTTGCCCTTATGCACGGAACTCTGTTTCTAAGTGCCAAGCACAGAAAGCCGCTAAATAAAATCTTTGCA
1681 ATTGTTTTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aguGUUCACUUCAUCACCCu 5'
             :| |||   ||||||| 
Target 5' attTATGTG-CCTAGTGGGg 3'
 1516 - 1534 144.00 -12.90
2 
miRNA  3' agUGUUCA---CUUCAUCACCCu 5'
            |||| |   || | |||||| 
Target 5' gtACAACTCTAGATGGAGTGGGc 3'
 513 - 535 130.00 -11.90
3 
miRNA  3' agUGUUCACUUCAU-CACCCu 5'
            | |:||| | || ||||| 
Target 5' agAGAGGTGCACTACGTGGGa 3'
 1037 - 1057 130.00 -13.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1208793 96 ClinVar
COSN27622855 19 COSMIC
COSN30478413 20 COSMIC
COSN30495957 30 COSMIC
COSN30522233 35 COSMIC
COSN31614106 35 COSMIC
COSN19665134 39 COSMIC
COSN31505736 43 COSMIC
COSN30131648 52 COSMIC
COSN30183147 52 COSMIC
COSN30474370 67 COSMIC
COSN30535262 70 COSMIC
COSN30491171 71 COSMIC
COSN30480905 72 COSMIC
COSN20074109 86 COSMIC
COSN30469216 99 COSMIC
COSN30103196 103 COSMIC
COSN20123484 106 COSMIC
COSN27392542 106 COSMIC
COSN30245967 133 COSMIC
COSN30119136 138 COSMIC
COSN28842520 189 COSMIC
COSN31527432 199 COSMIC
COSN26586573 217 COSMIC
COSN31565101 231 COSMIC
COSN8635476 309 COSMIC
COSN31587980 310 COSMIC
COSN16431211 410 COSMIC
COSN28629441 457 COSMIC
COSN30544427 533 COSMIC
COSN31480512 627 COSMIC
COSN30542177 633 COSMIC
COSN30169040 637 COSMIC
COSN31489399 676 COSMIC
COSN31533089 698 COSMIC
COSN8635475 728 COSMIC
COSN31549207 729 COSMIC
COSN26669737 741 COSMIC
COSN29467768 785 COSMIC
COSN25186502 801 COSMIC
COSN25185786 802 COSMIC
COSN31528778 818 COSMIC
COSN17076461 853 COSMIC
COSN31529580 856 COSMIC
COSN29120874 885 COSMIC
COSN28678686 891 COSMIC
COSN8889363 905 COSMIC
COSN1403596 946 COSMIC
COSN31960296 1148 COSMIC
COSN1403595 1174 COSMIC
COSN8889362 1256 COSMIC
COSN28196186 1297 COSMIC
COSN30542766 1354 COSMIC
COSN31597243 1367 COSMIC
COSN8635474 1391 COSMIC
COSN26564859 1446 COSMIC
COSN31548357 1609 COSMIC
COSN17590080 1661 COSMIC
COSN15874277 1668 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs887884962 3 dbSNP
rs752659709 7 dbSNP
rs778757194 10 dbSNP
rs372032554 14 dbSNP
rs755047289 15 dbSNP
rs1377267887 16 dbSNP
rs182443245 17 dbSNP
rs766655791 18 dbSNP
rs1475400789 19 dbSNP
rs975217822 19 dbSNP
rs1390978130 20 dbSNP
rs760984537 21 dbSNP
rs750744766 22 dbSNP
rs762130621 23 dbSNP
rs948025394 25 dbSNP
rs532340026 39 dbSNP
rs1242178056 40 dbSNP
rs759037360 41 dbSNP
rs776131865 42 dbSNP
rs777452049 48 dbSNP
rs1203889587 49 dbSNP
rs966627256 50 dbSNP
rs771871257 51 dbSNP
rs916591526 55 dbSNP
rs565063152 62 dbSNP
rs991778161 66 dbSNP
rs938654317 71 dbSNP
rs1024859677 76 dbSNP
rs1013444448 77 dbSNP
rs959439154 80 dbSNP
rs549819189 82 dbSNP
rs1237728760 83 dbSNP
rs530739789 94 dbSNP
rs17022673 96 dbSNP
rs1309278155 98 dbSNP
rs542151997 103 dbSNP
rs1474511984 104 dbSNP
rs1374411062 105 dbSNP
rs970767910 106 dbSNP
rs1036663949 107 dbSNP
rs1415886738 110 dbSNP
rs574621171 110 dbSNP
rs1003794722 111 dbSNP
rs1384378067 111 dbSNP
rs1028696884 112 dbSNP
rs902120672 113 dbSNP
rs998168911 113 dbSNP
rs1288799569 114 dbSNP
rs559423885 114 dbSNP
rs1004981834 115 dbSNP
rs541041337 116 dbSNP
rs1259729574 117 dbSNP
rs1184359747 124 dbSNP
rs1472950033 125 dbSNP
rs1491265594 126 dbSNP
rs887957046 126 dbSNP
rs1212485365 127 dbSNP
rs1277561543 127 dbSNP
rs1485007260 127 dbSNP
rs1491442917 127 dbSNP
rs536044359 127 dbSNP
rs78460482 127 dbSNP
rs879157577 127 dbSNP
rs1175668979 128 dbSNP
rs1373684900 128 dbSNP
rs1308514297 129 dbSNP
rs1398391659 129 dbSNP
rs1434066459 129 dbSNP
rs1208247442 130 dbSNP
rs1444398050 131 dbSNP
rs1279728616 132 dbSNP
rs1049098081 133 dbSNP
rs1236018409 135 dbSNP
rs1300682214 137 dbSNP
rs1346469135 138 dbSNP
rs1210828782 139 dbSNP
rs948144937 143 dbSNP
rs190281538 144 dbSNP
rs1194503242 145 dbSNP
rs1250241966 153 dbSNP
rs1454908042 159 dbSNP
rs1229611336 160 dbSNP
rs1393378692 161 dbSNP
rs895137867 162 dbSNP
rs1171072151 163 dbSNP
rs1051934860 169 dbSNP
rs1281970261 170 dbSNP
rs553146213 173 dbSNP
rs1297445118 177 dbSNP
rs933531318 178 dbSNP
rs771555987 186 dbSNP
rs774427470 189 dbSNP
rs936746108 191 dbSNP
rs868738439 193 dbSNP
rs925325814 198 dbSNP
rs759238161 199 dbSNP
rs1259838933 200 dbSNP
rs1455453196 202 dbSNP
rs1390630534 204 dbSNP
rs1159803868 218 dbSNP
rs558689400 233 dbSNP
rs966679166 235 dbSNP
rs1460891590 237 dbSNP
rs1413140866 243 dbSNP
rs536738606 248 dbSNP
rs1225845836 254 dbSNP
rs1251146370 258 dbSNP
rs184651814 272 dbSNP
rs1469152435 274 dbSNP
rs917854749 279 dbSNP
rs1251306016 290 dbSNP
rs1468092991 292 dbSNP
rs1180219067 293 dbSNP
rs1187246363 295 dbSNP
rs928593647 296 dbSNP
rs1426707105 301 dbSNP
rs977354006 304 dbSNP
rs992472913 304 dbSNP
rs1188263713 306 dbSNP
rs554843453 309 dbSNP
rs945835075 316 dbSNP
rs1270495645 317 dbSNP
rs914417248 326 dbSNP
rs1162357855 334 dbSNP
rs1393358750 336 dbSNP
rs1430993926 338 dbSNP
rs115500761 346 dbSNP
rs1381050245 348 dbSNP
rs1321665477 355 dbSNP
rs995317044 355 dbSNP
rs1335925441 359 dbSNP
rs921582538 363 dbSNP
rs1271647232 364 dbSNP
rs1229541375 368 dbSNP
rs1216736351 372 dbSNP
rs975797096 373 dbSNP
rs962438115 377 dbSNP
rs1432530905 382 dbSNP
rs1258060143 386 dbSNP
rs1476145226 387 dbSNP
rs966117616 393 dbSNP
rs1416866739 394 dbSNP
rs1367050643 400 dbSNP
rs1160791293 401 dbSNP
rs1342944401 404 dbSNP
rs1321038796 406 dbSNP
rs1015272604 407 dbSNP
rs1003845622 409 dbSNP
rs1298125276 414 dbSNP
rs1356728695 421 dbSNP
rs1417140719 422 dbSNP
rs867791171 425 dbSNP
rs1378854636 427 dbSNP
rs890777726 437 dbSNP
rs1224568674 443 dbSNP
rs1348088718 447 dbSNP
rs1286535798 453 dbSNP
rs1312053058 456 dbSNP
rs1015145407 457 dbSNP
rs1281109861 466 dbSNP
rs1486638749 468 dbSNP
rs1005098253 470 dbSNP
rs115231484 471 dbSNP
rs1027819907 488 dbSNP
rs1386003498 493 dbSNP
rs1168194925 494 dbSNP
rs1447936186 500 dbSNP
rs1012280211 506 dbSNP
rs547659012 527 dbSNP
rs1418141693 528 dbSNP
rs868777593 529 dbSNP
rs538654046 533 dbSNP
rs867844251 535 dbSNP
rs1173775922 543 dbSNP
rs1376713730 547 dbSNP
rs1056851892 550 dbSNP
rs1189644443 551 dbSNP
rs1437161637 554 dbSNP
rs1488402092 555 dbSNP
rs1245498408 561 dbSNP
rs1224498814 563 dbSNP
rs1321785532 569 dbSNP
rs998172137 576 dbSNP
rs900705876 590 dbSNP
rs564998982 593 dbSNP
rs1039619671 599 dbSNP
rs1343888846 600 dbSNP
rs1298014719 602 dbSNP
rs1371526682 605 dbSNP
rs902525295 607 dbSNP
rs112671668 609 dbSNP
rs1041623932 614 dbSNP
rs571269397 615 dbSNP
rs925378386 622 dbSNP
rs1279443752 627 dbSNP
rs1042468377 630 dbSNP
rs1437190685 642 dbSNP
rs749145080 645 dbSNP
rs917905716 653 dbSNP
rs992123421 654 dbSNP
rs959560079 658 dbSNP
rs1480130983 659 dbSNP
rs1193838303 662 dbSNP
rs879396202 678 dbSNP
rs1451974889 682 dbSNP
rs1428018769 685 dbSNP
rs777902918 687 dbSNP
rs976247525 692 dbSNP
rs965705799 699 dbSNP
rs1353086518 700 dbSNP
rs1392256093 707 dbSNP
rs1326769066 708 dbSNP
rs1373297722 711 dbSNP
rs1232087001 714 dbSNP
rs926520149 716 dbSNP
rs974330502 718 dbSNP
rs1270663904 723 dbSNP
rs1432949040 730 dbSNP
rs1213943694 738 dbSNP
rs962489094 741 dbSNP
rs983668181 742 dbSNP
rs1242172473 746 dbSNP
rs952333271 746 dbSNP
rs145228863 753 dbSNP
rs1170104046 754 dbSNP
rs114185243 761 dbSNP
rs139714258 764 dbSNP
rs1035081890 768 dbSNP
rs1397043168 768 dbSNP
rs1323027388 774 dbSNP
rs1438965591 774 dbSNP
rs1029737286 775 dbSNP
rs1327061977 779 dbSNP
rs1432835744 781 dbSNP
rs1268289225 783 dbSNP
rs996493523 785 dbSNP
rs900755522 787 dbSNP
rs1004045580 794 dbSNP
rs1017833096 799 dbSNP
rs1483794505 804 dbSNP
rs1274803646 811 dbSNP
rs902474003 822 dbSNP
rs548063829 823 dbSNP
rs1208841667 827 dbSNP
rs529862464 828 dbSNP
rs1274926899 829 dbSNP
rs1448169213 830 dbSNP
rs1042446405 831 dbSNP
rs1195966614 831 dbSNP
rs559704954 832 dbSNP
rs1477777838 842 dbSNP
rs1001455046 849 dbSNP
rs1310217557 852 dbSNP
rs1189165162 854 dbSNP
rs572460492 856 dbSNP
rs865799638 857 dbSNP
rs1219719627 861 dbSNP
rs904010640 862 dbSNP
rs1316312308 866 dbSNP
rs1287729173 870 dbSNP
rs1042520506 871 dbSNP
rs541280335 880 dbSNP
rs1010143376 882 dbSNP
rs1353284613 883 dbSNP
rs959590910 885 dbSNP
rs1298956339 886 dbSNP
rs1465765783 887 dbSNP
rs56809525 889 dbSNP
rs770017221 890 dbSNP
rs1212182320 891 dbSNP
rs1054392086 893 dbSNP
rs896537624 894 dbSNP
rs1056870004 895 dbSNP
rs1422375142 897 dbSNP
rs57163384 898 dbSNP
rs1473279677 899 dbSNP
rs1471275604 903 dbSNP
rs1156954214 904 dbSNP
rs1359950243 905 dbSNP
rs1250702844 907 dbSNP
rs1314591867 909 dbSNP
rs1199500174 913 dbSNP
rs1482101403 916 dbSNP
rs1257492722 918 dbSNP
rs781429810 922 dbSNP
rs543532930 934 dbSNP
rs78894179 935 dbSNP
rs1307946732 939 dbSNP
rs1347913236 941 dbSNP
rs1235688391 947 dbSNP
rs1286362659 964 dbSNP
rs1482560199 965 dbSNP
rs554616075 968 dbSNP
rs780045684 969 dbSNP
rs56957037 970 dbSNP
rs908378579 972 dbSNP
rs907541781 978 dbSNP
rs572261670 995 dbSNP
rs116624511 997 dbSNP
rs1379785971 999 dbSNP
rs1454719293 1002 dbSNP
rs1175439080 1006 dbSNP
rs1375921920 1011 dbSNP
rs1395619475 1012 dbSNP
rs955135545 1026 dbSNP
rs1377282682 1032 dbSNP
rs930881473 1038 dbSNP
rs751871057 1044 dbSNP
rs769678636 1051 dbSNP
rs1304891428 1052 dbSNP
rs1371100354 1061 dbSNP
rs1442558387 1073 dbSNP
rs1029376854 1082 dbSNP
rs975505355 1084 dbSNP
rs536873120 1085 dbSNP
rs920824923 1092 dbSNP
rs780281665 1095 dbSNP
rs1341854313 1103 dbSNP
rs963719318 1114 dbSNP
rs1196997237 1118 dbSNP
rs1388440758 1121 dbSNP
rs1018304001 1123 dbSNP
rs1237722242 1124 dbSNP
rs1157589975 1125 dbSNP
rs1459324461 1135 dbSNP
rs1469070256 1136 dbSNP
rs1195640211 1141 dbSNP
rs1001099161 1142 dbSNP
rs1432560935 1150 dbSNP
rs904061195 1151 dbSNP
rs959533808 1154 dbSNP
rs1463807086 1156 dbSNP
rs1169690034 1158 dbSNP
rs1394837547 1163 dbSNP
rs192103667 1171 dbSNP
rs1323361028 1176 dbSNP
rs868842203 1179 dbSNP
rs1366242977 1181 dbSNP
rs1186257686 1185 dbSNP
rs1021141135 1189 dbSNP
rs571351644 1190 dbSNP
rs896581018 1196 dbSNP
rs1257848993 1197 dbSNP
rs1215753607 1203 dbSNP
rs1056523018 1205 dbSNP
rs1183877792 1208 dbSNP
rs1488169220 1209 dbSNP
rs938036775 1210 dbSNP
rs1263852828 1218 dbSNP
rs905173061 1221 dbSNP
rs1038729822 1222 dbSNP
rs188847004 1225 dbSNP
rs900329601 1229 dbSNP
rs1348811717 1230 dbSNP
rs1453765124 1235 dbSNP
rs1329799002 1236 dbSNP
rs538368681 1238 dbSNP
rs1261342385 1239 dbSNP
rs1363065184 1249 dbSNP
rs142931443 1253 dbSNP
rs549427783 1255 dbSNP
rs1235393280 1258 dbSNP
rs529852067 1259 dbSNP
rs184157101 1260 dbSNP
rs1321347175 1266 dbSNP
rs1216662852 1269 dbSNP
rs547760527 1279 dbSNP
rs1315095626 1280 dbSNP
rs1453738951 1281 dbSNP
rs1262547234 1289 dbSNP
rs886214893 1293 dbSNP
rs1215762400 1294 dbSNP
rs1047489839 1296 dbSNP
rs1179757128 1301 dbSNP
rs933803887 1303 dbSNP
rs920269527 1308 dbSNP
rs1160717393 1311 dbSNP
rs1437844800 1321 dbSNP
rs922359043 1324 dbSNP
rs938303080 1325 dbSNP
rs1386355830 1330 dbSNP
rs1450721450 1332 dbSNP
rs928140430 1333 dbSNP
rs975177834 1346 dbSNP
rs758837822 1349 dbSNP
rs966885921 1350 dbSNP
rs1455919508 1352 dbSNP
rs768925858 1353 dbSNP
rs989570229 1355 dbSNP
rs1239357087 1357 dbSNP
rs1333861660 1360 dbSNP
rs1369760077 1361 dbSNP
rs925639353 1365 dbSNP
rs745617483 1372 dbSNP
rs957982483 1374 dbSNP
rs1207824772 1376 dbSNP
rs1448551699 1378 dbSNP
rs750908684 1386 dbSNP
rs1245910896 1387 dbSNP
rs968292232 1388 dbSNP
rs1438478420 1389 dbSNP
rs1173713200 1391 dbSNP
rs567726402 1396 dbSNP
rs76084019 1408 dbSNP
rs1266607583 1410 dbSNP
rs1358912035 1411 dbSNP
rs960891210 1412 dbSNP
rs1443237371 1413 dbSNP
rs543067784 1414 dbSNP
rs1333548086 1425 dbSNP
rs1374775346 1434 dbSNP
rs566205213 1435 dbSNP
rs1304233408 1436 dbSNP
rs1347094798 1442 dbSNP
rs1208052186 1455 dbSNP
rs1277692096 1457 dbSNP
rs900448470 1460 dbSNP
rs1206197527 1462 dbSNP
rs867589316 1465 dbSNP
rs1018763688 1467 dbSNP
rs1457033568 1470 dbSNP
rs1193775129 1471 dbSNP
rs1002288565 1472 dbSNP
rs1479308714 1473 dbSNP
rs905223177 1475 dbSNP
rs1171290357 1481 dbSNP
rs1424927866 1482 dbSNP
rs1038339445 1486 dbSNP
rs1410818998 1490 dbSNP
rs531310961 1492 dbSNP
rs1173272313 1508 dbSNP
rs138944580 1509 dbSNP
rs1465276946 1513 dbSNP
rs1326707779 1516 dbSNP
rs41301299 1525 dbSNP
rs886288429 1541 dbSNP
rs1047436701 1550 dbSNP
rs1341752748 1555 dbSNP
rs1255894261 1561 dbSNP
rs887047246 1565 dbSNP
rs1368439518 1572 dbSNP
rs1295810328 1578 dbSNP
rs781013455 1584 dbSNP
rs933848054 1600 dbSNP
rs757160125 1601 dbSNP
rs1197382627 1603 dbSNP
rs1246709848 1610 dbSNP
rs191626254 1615 dbSNP
rs1196353112 1617 dbSNP
rs1421892995 1618 dbSNP
rs1477634280 1621 dbSNP
rs922444197 1626 dbSNP
rs553939455 1627 dbSNP
rs1403611049 1634 dbSNP
rs1322967992 1637 dbSNP
rs1057671 1639 dbSNP
rs751031273 1644 dbSNP
rs938257647 1646 dbSNP
rs1039898879 1652 dbSNP
rs1046657057 1653 dbSNP
rs535887137 1658 dbSNP
rs372983494 1659 dbSNP
rs1233542937 1661 dbSNP
rs945493452 1662 dbSNP
rs377390859 1663 dbSNP
rs925653884 1665 dbSNP
rs978442460 1672 dbSNP
rs545320518 1678 dbSNP
rs1428660339 1682 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BACD1
Disease MIMAT0016850
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020024. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aguguucacuucAUCACCCu 5'
                      ||||||| 
Target 5' ---------gccUAGUGGGg 3'
 		1 - 11
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020024
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD1 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000207157.3 | 3UTR | GCCUAGUGGGGAAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4301 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081134 LDLR low density lipoprotein receptor 2 4
MIRT090911 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT229436 MECP2 methyl-CpG binding protein 2 2 2
MIRT274717 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT350957 BACH1 BTB domain and CNC homolog 1 2 2
MIRT386722 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT446022 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT481303 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 14
MIRT483959 ZNF354B zinc finger protein 354B 2 6
MIRT495667 TUBAL3 tubulin alpha like 3 2 2
MIRT496554 TBX15 T-box 15 2 2
MIRT497702 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498105 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT512535 SEMA4D semaphorin 4D 2 2
MIRT512556 MFN2 mitofusin 2 2 6
MIRT521465 RABGAP1 RAB GTPase activating protein 1 2 6
MIRT526236 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT526743 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527578 BRD7 bromodomain containing 7 2 4
MIRT528038 WT1 Wilms tumor 1 2 2
MIRT528267 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528505 HTR7 5-hydroxytryptamine receptor 7 2 4
MIRT528758 RPS27 ribosomal protein S27 2 6
MIRT528999 IPO9 importin 9 2 2
MIRT529701 MRPL30 mitochondrial ribosomal protein L30 2 2
MIRT529781 C17orf82 chromosome 17 open reading frame 82 2 2
MIRT533797 TMEM119 transmembrane protein 119 2 6
MIRT535308 PHF12 PHD finger protein 12 2 2
MIRT535917 MKL2 MKL1/myocardin like 2 2 2
MIRT544892 OSBPL1A oxysterol binding protein like 1A 2 2
MIRT555423 PPIC peptidylprolyl isomerase C 2 2
MIRT562068 KLHL15 kelch like family member 15 2 2
MIRT565623 SLC31A1 solute carrier family 31 member 1 2 2
MIRT565661 SIX1 SIX homeobox 1 2 2
MIRT570138 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT571045 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT621232 LMAN1 lectin, mannose binding 1 2 2
MIRT622272 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623844 GAN gigaxonin 2 2
MIRT626158 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT626464 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT632087 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT637243 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT642710 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT643611 KANSL3 KAT8 regulatory NSL complex subunit 3 2 2
MIRT644270 PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 2 2
MIRT645470 SPIN3 spindlin family member 3 2 2
MIRT649193 DNPEP aspartyl aminopeptidase 2 2
MIRT650776 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT651345 ZC2HC1C zinc finger C2HC-type containing 1C 2 2
MIRT652237 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT652587 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654591 PURA purine rich element binding protein A 2 2
MIRT654649 PTAFR platelet activating factor receptor 2 2
MIRT656842 KLF7 Kruppel like factor 7 2 2
MIRT657209 IKZF2 IKAROS family zinc finger 2 2 2
MIRT658513 ETV3 ETS variant 3 2 2
MIRT659448 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT668816 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT669067 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT677711 ELOF1 elongation factor 1 homolog 2 4
MIRT687146 PTPN12 protein tyrosine phosphatase, non-receptor type 12 2 2
MIRT698498 THOC2 THO complex 2 2 2
MIRT707930 PPP1R3D protein phosphatase 1 regulatory subunit 3D 4 2
MIRT708737 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710031 POLL DNA polymerase lambda 2 2
MIRT712175 STK4 serine/threonine kinase 4 2 2
MIRT715297 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT716892 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT717378 RBM41 RNA binding motif protein 41 2 2
MIRT718082 CLIC5 chloride intracellular channel 5 2 2
MIRT718721 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT719152 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719224 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719528 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT719861 KLF2 Kruppel like factor 2 2 2
MIRT720326 CAMK2G calcium/calmodulin dependent protein kinase II gamma 2 2
MIRT721596 SREBF1 sterol regulatory element binding transcription factor 1 2 2
MIRT722020 NEBL nebulette 2 2
MIRT722484 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT722614 TEAD1 TEA domain transcription factor 1 2 2
MIRT723664 RPTN repetin 2 2
MIRT723939 SVOP SV2 related protein 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive High Hepatocellular Carcinoma cell line (Hep3B, 97L)
hsa-miR-4301 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-mir-4301 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4301 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4301 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4301 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-miR-4301 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4301 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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