miRTarBase - #MIRT496623


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pre-miRNA Information
pre-miRNA hsa-mir-4640   
Genomic Coordinates chr6: 30890883 - 30890972
Description Homo sapiens miR-4640 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4640-5p
Sequence 9| UGGGCCAGGGAGCAGCUGGUGGG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1392105945 7 dbSNP
rs939712790 9 dbSNP
rs762825841 15 dbSNP
rs71552023 20 dbSNP
rs1305909531 21 dbSNP
rs750017220 21 dbSNP
rs1375436057 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B32FZJ miR-4640 Safety Biomarker (SAF) Clinical/Experimental Data Expression lower Urine Quantitative polymerase chain reaction
Gene Information
Gene Symbol TMEM67   
Synonyms JBTS6, MECKELIN, MKS3, NPHP11, TNEM67
Description transmembrane protein 67
Transcript NM_001142301   
Other Transcripts NM_153704   
Expression
Putative miRNA Targets on TMEM67
3'UTR of TMEM67
(miRNA target sites are highlighted)		 
>TMEM67|NM_001142301|3'UTR
   1 CTTCCTGAATAAATAACTTAAAGACTCAGTATAATCATGGCCAAAAAAAAGTCATGATATCAGGTTAGTTTGCCATATTT
  81 TTTAAAACTTATAATGCAGACTATTCTGTTTTTGTTTTTTATTTGCAGAAAGATTTATTTTTATAACTTGGGAATATATA
 161 ACCTGATATAATAGAAAATACTGTTTTCCCATTGTGTGTAGTATTTAATGCAGTAAATAATAAATTAATACTGACAGTGA
 241 GGCCAAAAAAAATCTAAATGTTGCTTTCAGCATAATACTTTTTAATGCTAATTAAAACAGTCCCCATCATTTGTCTCTGT
 321 AGATTATTTTATAAACTGAGAGCTGCCTGAATCTTCTCACATTGACAAAGTAATTTGATTCCAAGTTTAAGACTAGTTTT
 401 CAGTTTGATATTTTCATGTTTTGTGTGCTTATGGTTAAATAAATGTTGAAAGATATTTTCAAGTTTACTTAGAAATTTTA
 481 AATTGTATTATTGCTGATTCAATTTGCATCATTCTAATTGCTCATCCTCTTTGGCAGTGGATTAATTCACTGTTGGGTTA
 561 ATATGCATCTCATGAAATGATATCTTTTCATTCCTTTGTATACCTGTATTAGGTCAGTATACGCTTTCCATGAAATATAT
 641 TTGCATTTCTAATATAGTTTACATTTATTAAGTTATAACGTATGACATTTTTCCCAATATCATTTTTTATACATTTTAAT
 721 TACTTAATGTTTTAAGAGTTCTCTTCCAGAGTTTTGCTTTTCAATTACGTTTAAAGACTGTAAATAACAAACAGTAAGGC
 801 TGGGCGCTGTGGCTTACGCCTGTAATCCCAGCACTTTGGAAGGCCAAGGCACGTGGATCACTTTAGGTCAGGAGTTCAAG
 881 AACAGCCTGGCCAACATGGAAAACCCCATCTCTACAAAAAATACAAAAATTAGTTGGATGTGGTGGCCTGTAATCCCAGC
 961 TATTTGGGAGGCTGAGGCATGAGAATAGCTTGAAACCAGGAGGTGGAGGCTGTAGTGAGCCAGATAGCACCACTGCACTC
1041 CAGCCAGGATGACAGAGCAAGACCCTGTCTCAGAAAAAACAAAAACAAAACACTGTAAATGTATCATGTTTCTCACTGCT
1121 TTCTATGTTAATGCTGTGTAAATACTTAAAATGGAATACTGTATAAATATTATTTATATTTTCTCAGATGAAAATATATA
1201 CTAAAACATTTGGTATTTCTGTTTTCTGTTTCATTAATGTATATCTGATGGAGTACCATTTAGGAATATAACATTATTGG
1281 GGCAGAGGTCCCAGCCATTGCCAAAGTTGAATCTTTTACATTTCCCTGAATCTTGAGGATGACTGAAAAGGAAGTCTTTG
1361 AAACTGCAGTTTCTGAAGGATCACAGTACAGGAATGCCTTTATAAAAGCTGCAGAGATAAATACATGTACTTATATGGCA
1441 TGGATATTTAAAACCACTCACTCAGAAGCATATGAAAGAAATTCAACCATCATTCAACATAGAAGAAGTTAATTTTAGTG
1521 CAAAAGTTTTTAAGTATTAAATTTCACAATAAAGGATCAATTGGCTTACTTGCTGATAAATTAAAACAGAAAACATTTAA
1601 AATCATTCTAAATTTTGTATGATATTTTTATTTTGGCTAGGTGCATAAAAATGTGTTCAGATTTTCAAAAAAAAAAAAAA
1681 AAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gggUGGUCGACGAG--------GGACCGGgu 5'
             ::|||  |:||        |||||||  
Target 5' tagGTCAGGAGTTCAAGAACAGCCTGGCCaa 3'
 864 - 894 130.00 -19.20
2 
miRNA  3' gggUGGUCGAC--GAGGGACCGGGu 5'
             |::||:||  : :  |||||: 
Target 5' aaaATTAGTTGGATGTGGTGGCCTg 3'
 926 - 950 106.00 -13.40
3 
miRNA  3' ggguggUCGACGAGGGACCGGGu 5'
                |||    ||||| |:| 
Target 5' tgacagAGCAAGACCCTGTCTCa 3'
 1050 - 1072 105.00 -15.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
262739 20 ClinVar
914980 26 ClinVar
363930 180 ClinVar
363931 219 ClinVar
913024 280 ClinVar
363932 301 ClinVar
913394 513 ClinVar
913395 581 ClinVar
914507 691 ClinVar
914508 762 ClinVar
914509 823 ClinVar
363933 853 ClinVar
363934 854 ClinVar
363935 942 ClinVar
363936 943 ClinVar
912309 1100 ClinVar
913429 1425 ClinVar
363937 1435 ClinVar
363938 1654 ClinVar
COSN31496143 23 COSMIC
COSN31502984 28 COSMIC
COSN30502036 41 COSMIC
COSN30102566 42 COSMIC
COSN18733116 51 COSMIC
COSN30557419 51 COSMIC
COSN30482664 66 COSMIC
COSN21382894 70 COSMIC
COSN23792390 74 COSMIC
COSN31546690 113 COSMIC
COSN28212046 116 COSMIC
COSN20974506 575 COSMIC
COSN2299457 585 COSMIC
COSN17075953 623 COSMIC
COSN17746295 772 COSMIC
COSN26526567 844 COSMIC
COSN28357271 883 COSMIC
COSN9688748 1238 COSMIC
COSN32005999 1378 COSMIC
COSN5116729 1583 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1465302709 1 dbSNP
rs750254911 6 dbSNP
rs1298616157 8 dbSNP
rs1408146548 8 dbSNP
rs369159461 10 dbSNP
rs1319265620 15 dbSNP
rs780146264 18 dbSNP
rs55850117 20 dbSNP
rs1425056120 31 dbSNP
rs1299723136 32 dbSNP
rs368465995 33 dbSNP
rs1224440561 34 dbSNP
rs1265562236 35 dbSNP
rs780845308 37 dbSNP
rs747794606 39 dbSNP
rs755765642 41 dbSNP
rs769405960 43 dbSNP
rs775180320 43 dbSNP
rs540908817 44 dbSNP
rs1423844540 47 dbSNP
rs748833933 49 dbSNP
rs1446762337 51 dbSNP
rs768370423 51 dbSNP
rs746273119 53 dbSNP
rs772352774 58 dbSNP
rs559891501 60 dbSNP
rs747512381 65 dbSNP
rs776754092 71 dbSNP
rs1345263572 72 dbSNP
rs1432203515 75 dbSNP
rs767218402 76 dbSNP
rs1366405658 91 dbSNP
rs528635378 92 dbSNP
rs904058031 93 dbSNP
rs541946716 95 dbSNP
rs951492488 97 dbSNP
rs1017725202 101 dbSNP
rs1228315935 103 dbSNP
rs762856901 106 dbSNP
rs562339925 107 dbSNP
rs751612440 110 dbSNP
rs754934599 112 dbSNP
rs981221232 116 dbSNP
rs1035461725 122 dbSNP
rs965167888 125 dbSNP
rs1204613220 131 dbSNP
rs1387289929 133 dbSNP
rs1323341388 134 dbSNP
rs1466703082 138 dbSNP
rs1400638147 140 dbSNP
rs958541973 144 dbSNP
rs1475329745 145 dbSNP
rs991384916 159 dbSNP
rs997489765 160 dbSNP
rs1233657634 163 dbSNP
rs1030355767 166 dbSNP
rs1481767789 169 dbSNP
rs914515136 170 dbSNP
rs947066662 173 dbSNP
rs530988214 174 dbSNP
rs886063174 180 dbSNP
rs1259025775 181 dbSNP
rs1195451275 184 dbSNP
rs977521547 198 dbSNP
rs1276416970 199 dbSNP
rs955246274 201 dbSNP
rs377764263 211 dbSNP
rs886063175 219 dbSNP
rs1301131466 221 dbSNP
rs1448422847 226 dbSNP
rs1400383361 230 dbSNP
rs1327535404 233 dbSNP
rs1403854353 236 dbSNP
rs1453596978 236 dbSNP
rs1194119434 243 dbSNP
rs766748624 250 dbSNP
rs908358361 257 dbSNP
rs933034808 260 dbSNP
rs1051524128 261 dbSNP
rs1442017880 270 dbSNP
rs974220929 274 dbSNP
rs1427252952 276 dbSNP
rs1181114377 278 dbSNP
rs752060945 280 dbSNP
rs1280956994 290 dbSNP
rs937761623 298 dbSNP
rs886063176 301 dbSNP
rs34809974 302 dbSNP
rs538922003 303 dbSNP
rs1056110265 318 dbSNP
rs558577799 318 dbSNP
rs1377490473 319 dbSNP
rs1291453873 337 dbSNP
rs1367273993 343 dbSNP
rs1442109664 363 dbSNP
rs1278477492 399 dbSNP
rs1439357040 404 dbSNP
rs755679387 408 dbSNP
rs1306267813 427 dbSNP
rs1363723636 434 dbSNP
rs1334391097 446 dbSNP
rs1415858465 453 dbSNP
rs572366116 463 dbSNP
rs942864958 467 dbSNP
rs112233974 471 dbSNP
rs1042659321 475 dbSNP
rs904023365 483 dbSNP
rs1158105578 486 dbSNP
rs936820979 488 dbSNP
rs1273847986 492 dbSNP
rs1039613455 496 dbSNP
rs900563548 497 dbSNP
rs1309364324 507 dbSNP
rs1485428137 509 dbSNP
rs570774838 513 dbSNP
rs1255166584 536 dbSNP
rs998024934 540 dbSNP
rs1218470646 541 dbSNP
rs183220842 542 dbSNP
rs1265101074 552 dbSNP
rs1221637070 557 dbSNP
rs1357848559 568 dbSNP
rs551707990 573 dbSNP
rs755440857 575 dbSNP
rs995505639 581 dbSNP
rs1025621708 583 dbSNP
rs887126629 584 dbSNP
rs565331655 585 dbSNP
rs1035742251 593 dbSNP
rs534751646 599 dbSNP
rs1318230554 601 dbSNP
rs958565827 603 dbSNP
rs1416058722 604 dbSNP
rs554347125 606 dbSNP
rs568268659 608 dbSNP
rs959124492 609 dbSNP
rs1419545880 613 dbSNP
rs1429787336 620 dbSNP
rs991897515 621 dbSNP
rs536811866 623 dbSNP
rs969064642 624 dbSNP
rs752705934 632 dbSNP
rs1171018008 633 dbSNP
rs763884998 654 dbSNP
rs1328399557 656 dbSNP
rs1387057511 663 dbSNP
rs1232106125 668 dbSNP
rs1434965482 671 dbSNP
rs924245205 677 dbSNP
rs35321711 680 dbSNP
rs756327958 680 dbSNP
rs557304435 681 dbSNP
rs987178996 683 dbSNP
rs1363085944 690 dbSNP
rs535033320 691 dbSNP
rs1429254271 693 dbSNP
rs1352084874 701 dbSNP
rs942873889 702 dbSNP
rs1312275522 710 dbSNP
rs1326712684 720 dbSNP
rs749545941 720 dbSNP
rs1335802299 726 dbSNP
rs1460967832 738 dbSNP
rs546117654 739 dbSNP
rs1039176924 756 dbSNP
rs553442637 762 dbSNP
rs1429274367 769 dbSNP
rs188098909 770 dbSNP
rs1274772056 778 dbSNP
rs898727742 780 dbSNP
rs933403832 796 dbSNP
rs758228542 797 dbSNP
rs1253510153 799 dbSNP
rs542334986 803 dbSNP
rs557700820 805 dbSNP
rs575810585 806 dbSNP
rs779719406 807 dbSNP
rs931531877 818 dbSNP
rs544358629 819 dbSNP
rs1047313888 821 dbSNP
rs1295335321 823 dbSNP
rs1016273715 827 dbSNP
rs564441988 830 dbSNP
rs1486557578 834 dbSNP
rs898386209 837 dbSNP
rs1440350987 850 dbSNP
rs1033503981 851 dbSNP
rs114214029 853 dbSNP
rs34080297 853 dbSNP
rs191740525 854 dbSNP
rs1024647356 859 dbSNP
rs1166689284 872 dbSNP
rs1415935037 886 dbSNP
rs1410158574 891 dbSNP
rs1192925007 897 dbSNP
rs1400508051 900 dbSNP
rs1239479517 905 dbSNP
rs1177227144 916 dbSNP
rs966436647 916 dbSNP
rs1319484506 923 dbSNP
rs1057139293 934 dbSNP
rs1347537159 938 dbSNP
rs112317911 942 dbSNP
rs886063177 943 dbSNP
rs936927595 961 dbSNP
rs1021854369 964 dbSNP
rs559329364 969 dbSNP
rs1311601237 977 dbSNP
rs1392002948 980 dbSNP
rs968595071 985 dbSNP
rs1235315880 997 dbSNP
rs1286698661 1006 dbSNP
rs1372929295 1011 dbSNP
rs1296653203 1025 dbSNP
rs922122104 1031 dbSNP
rs1375840436 1035 dbSNP
rs1172718016 1047 dbSNP
rs1432808307 1050 dbSNP
rs1326728629 1053 dbSNP
rs1223067007 1055 dbSNP
rs998738105 1065 dbSNP
rs1159261180 1069 dbSNP
rs1031595823 1074 dbSNP
rs1284849980 1075 dbSNP
rs954357981 1076 dbSNP
rs987168936 1109 dbSNP
rs1183244771 1110 dbSNP
rs574284547 1114 dbSNP
rs1485763369 1115 dbSNP
rs1258685654 1126 dbSNP
rs528047531 1127 dbSNP
rs548282373 1136 dbSNP
rs1256151534 1148 dbSNP
rs1485002380 1157 dbSNP
rs910288485 1160 dbSNP
rs1262990971 1164 dbSNP
rs1239927461 1172 dbSNP
rs1316407120 1179 dbSNP
rs1304876952 1197 dbSNP
rs879227200 1198 dbSNP
rs907918005 1220 dbSNP
rs183480271 1226 dbSNP
rs973194242 1227 dbSNP
rs1249172714 1232 dbSNP
rs186657710 1239 dbSNP
rs1362442528 1246 dbSNP
rs1289372999 1252 dbSNP
rs920057884 1254 dbSNP
rs1361576828 1257 dbSNP
rs1166230988 1263 dbSNP
rs550843544 1278 dbSNP
rs940771454 1297 dbSNP
rs1187734524 1306 dbSNP
rs1159569116 1310 dbSNP
rs1410775834 1320 dbSNP
rs1264559844 1348 dbSNP
rs1206242518 1350 dbSNP
rs1485793265 1352 dbSNP
rs1259060125 1356 dbSNP
rs778764070 1369 dbSNP
rs1413307330 1373 dbSNP
rs1037676706 1374 dbSNP
rs899189884 1377 dbSNP
rs995416991 1379 dbSNP
rs1055489998 1380 dbSNP
rs1342149564 1382 dbSNP
rs931487994 1383 dbSNP
rs1381605685 1390 dbSNP
rs1382648150 1390 dbSNP
rs570652277 1391 dbSNP
rs574967270 1410 dbSNP
rs1013334346 1414 dbSNP
rs1024783132 1425 dbSNP
rs1162339737 1431 dbSNP
rs1416703476 1433 dbSNP
rs539776425 1434 dbSNP
rs886063178 1435 dbSNP
rs1375152113 1436 dbSNP
rs1306398884 1441 dbSNP
rs1194281176 1445 dbSNP
rs1428472719 1447 dbSNP
rs1260220482 1454 dbSNP
rs1335456913 1458 dbSNP
rs966404236 1474 dbSNP
rs192470614 1487 dbSNP
rs1212071483 1493 dbSNP
rs1341680113 1501 dbSNP
rs1488831196 1501 dbSNP
rs1226384410 1506 dbSNP
rs1047303298 1508 dbSNP
rs908835212 1509 dbSNP
rs938673043 1512 dbSNP
rs573209438 1515 dbSNP
rs1057085034 1519 dbSNP
rs957984732 1524 dbSNP
rs185714620 1528 dbSNP
rs535445109 1535 dbSNP
rs1347891468 1541 dbSNP
rs1466881573 1548 dbSNP
rs1396719912 1550 dbSNP
rs1168894366 1552 dbSNP
rs1212485449 1556 dbSNP
rs577744213 1576 dbSNP
rs1461777873 1585 dbSNP
rs1272028680 1593 dbSNP
rs1013388851 1603 dbSNP
rs1196060188 1606 dbSNP
rs555839637 1609 dbSNP
rs776701095 1611 dbSNP
rs1234909576 1635 dbSNP
rs1477251719 1637 dbSNP
rs575602477 1642 dbSNP
rs998727955 1646 dbSNP
rs1337194120 1652 dbSNP
rs544858713 1654 dbSNP
rs987612297 1660 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BAC
Disease MIMAT0019699
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020023. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gggugguCGACGAG---GGACCGGgu 5'
                 |: || |   ::|||||  
Target 5' -------GUGGCACGAUUUUGGCC-- 3'
 		1 - 17
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020023
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BAC / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000453321.3 | 3UTR | GUGGCACGAUUUUGGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4640-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100106 ABT1 activator of basal transcription 1 2 8
MIRT248144 LMBR1L limb development membrane protein 1 like 2 2
MIRT327062 KLHL15 kelch like family member 15 2 2
MIRT347231 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT450221 CENPN centromere protein N 2 2
MIRT451264 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT452701 C1orf226 chromosome 1 open reading frame 226 2 2
MIRT453212 CERS1 ceramide synthase 1 2 2
MIRT454822 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT454883 RAD50 RAD50 double strand break repair protein 2 2
MIRT455783 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT455858 TMEM254 transmembrane protein 254 2 2
MIRT457615 UPK3BL uroplakin 3B like 1 2 2
MIRT457822 ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 2 4
MIRT458344 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458376 ITM2C integral membrane protein 2C 2 2
MIRT458928 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT459066 WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2 2
MIRT460138 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT460818 FSTL4 follistatin like 4 2 2
MIRT461285 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT462738 EFNB1 ephrin B1 2 2
MIRT464556 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT477910 DUSP2 dual specificity phosphatase 2 2 2
MIRT479073 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 4
MIRT479534 CDC5L cell division cycle 5 like 2 4
MIRT485628 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT489896 PPIC peptidylprolyl isomerase C 2 4
MIRT490737 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491201 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT492681 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT494593 ATG7 autophagy related 7 2 2
MIRT495061 PADI3 peptidyl arginine deiminase 3 2 4
MIRT496623 TMEM67 transmembrane protein 67 2 2
MIRT497177 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT498217 TLN2 talin 2 2 2
MIRT498306 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT499668 NPHP3 nephrocystin 3 2 2
MIRT508080 ANKRD52 ankyrin repeat domain 52 2 2
MIRT509707 ANKRD23 ankyrin repeat domain 23 2 2
MIRT509841 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT512814 ARRDC2 arrestin domain containing 2 2 2
MIRT513353 SLIT1 slit guidance ligand 1 2 2
MIRT514293 FXYD5 FXYD domain containing ion transport regulator 5 2 2
MIRT516598 FAM89A family with sequence similarity 89 member A 2 4
MIRT516616 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT518348 CCL5 C-C motif chemokine ligand 5 2 2
MIRT520130 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT522072 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT526461 OSBPL5 oxysterol binding protein like 5 2 2
MIRT528278 MBL2 mannose binding lectin 2 2 2
MIRT534844 RAB15 RAB15, member RAS oncogene family 2 4
MIRT542245 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT543299 ZNF585B zinc finger protein 585B 2 2
MIRT552456 ZNF410 zinc finger protein 410 2 2
MIRT553641 TJAP1 tight junction associated protein 1 2 2
MIRT557103 HOXA3 homeobox A3 2 2
MIRT570782 FANCA Fanconi anemia complementation group A 2 2
MIRT630912 ZMAT2 zinc finger matrin-type 2 2 2
MIRT631034 ZNF878 zinc finger protein 878 2 2
MIRT639017 AAK1 AP2 associated kinase 1 2 2
MIRT648596 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT648939 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT652834 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT659347 CSRP1 cysteine and glycine rich protein 1 2 2
MIRT664163 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT670511 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT671246 TMEM41B transmembrane protein 41B 2 2
MIRT672120 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT672313 CD3D CD3d molecule 2 2
MIRT672543 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT673036 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT673814 DARS aspartyl-tRNA synthetase 2 2
MIRT674858 GINM1 glycoprotein integral membrane 1 2 2
MIRT674970 SH3BP2 SH3 domain binding protein 2 2 2
MIRT675185 KIF1C kinesin family member 1C 2 2
MIRT675219 UGDH UDP-glucose 6-dehydrogenase 2 2
MIRT675558 MED16 mediator complex subunit 16 2 2
MIRT682566 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT684640 PDE4C phosphodiesterase 4C 2 2
MIRT689722 ATXN2 ataxin 2 2 2
MIRT693594 SLC39A1 solute carrier family 39 member 1 2 2
MIRT704745 CDKN2B cyclin dependent kinase inhibitor 2B 2 2
MIRT712779 ZNF154 zinc finger protein 154 2 2
MIRT718118 OTOF otoferlin 2 2
MIRT720115 SAMD4A sterile alpha motif domain containing 4A 2 2
MIRT720275 EIF1AD eukaryotic translation initiation factor 1A domain containing 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4640 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4640-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4640-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4640-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4640-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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