pre-miRNA Information | |
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pre-miRNA | hsa-mir-6752 |
Genomic Coordinates | chr11: 67490245 - 67490315 |
Description | Homo sapiens miR-6752 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-6752-3p | |||||||||||||||
Sequence | 51| UCCCUGCCCCCAUACUCCCAG |71 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Meta-analysis | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | DNAJC30 | ||||||||||||||||||||
Synonyms | WBSCR18 | ||||||||||||||||||||
Description | DnaJ heat shock protein family (Hsp40) member C30 | ||||||||||||||||||||
Transcript | NM_032317 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on DNAJC30 | |||||||||||||||||||||
3'UTR of DNAJC30 (miRNA target sites are highlighted) |
>DNAJC30|NM_032317|3'UTR 1 TCGGAGAGAGAAGGGAAGGGGAGTGTCCCCAGCCAACCCCCCAGAAACGGCCTTTTTTCCTGCCTCTGAACCCTTGGCCA 81 TTGATAGTCTACCTTTGCTGGGATCCGAAGGAACTGTACTCCCCCTGCCCTCCCCGACCCGCCCAGCTTAGCCGATGACC 161 TGCACATCGCTCCACTGTGGTCCAGAAAAGGAGGCCTTTCGATGTCTGAGAAAGAGGCCCCACGCTGTAGAGTCCCGAAA 241 GCCCAGGAGTGAAGGGGGTTCCTGGAGTCTCTAGGGTGCTTCTTCCAGAGTCTGTCTTCTTGCTTCCAGATGTGGTCAAC 321 TTCTGGAACACTCGCTGTAGCTTTATTGTTTAGCCCCAAGCAAGATTTATCTCCTCCTGCCCCGCATGTGTATGGTGGGC 401 CTCTGTAACCTTGAAATGTGCAATGTGACCAATTGTTGACTACCAAAAGAAAAGGTCTGGGGTTGTACGAAACTTGTCTT 481 TCTGTGACTTCCCCAAGCCGCAGGTGAGACCTGGTCCAGGGTAAGAATGGGATCGGTGGAGAGCCTGTCGTTCCTCCCGC 561 TAAGGTCAGCCCCCTGGGGCACTCCTCCTTATGTTGATAGCATGTAGGAGTGAGAAAAAGTCATTGAGCATAAGGAATGA 641 GTGTTCCTGTGCCCATATTTAATGTGTGACCTTGGAGAAGTTACTCTGTAGGCATGACAGCAGAGGAGAAAATCATTTGG 721 CATCTTGAGGTCTGTCATGCTTTATTATCCATAGTTTTTGGGGGGTTTTTTGTTTTGTTTTGTTTTTGAGATGGAGTCTT 801 GCGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCGATCTTAGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTCT 881 CCTGCCTCAGCCTCCTGTGTAACTGGGATTACAGGCTCCCACCACACCTGGCTAGTGTTTTGTATTTTTAGTAGATACGG 961 GGTTTCACCATGCTGGCCAGACTGAGGTCTCGAACTGCCGACCTCAGGCTGTCTGCCCGTCCAGCCTCCCAAAGTGCTGG 1041 GATTGCAGGCATGAGCCACTGCTCCCGGCCCTATTATCCATAGTTCTAATCCACAGGGATTACAGCATAATGCTAGCAGG 1121 GCCAGGTTCATCCTTGAGACAGTGTGGCTGGCTGTCACCTGGTCCTCCCTTTACCAGCCAGCCCCATTGCACACTGTGCA 1201 GCCCATCCCCTCCCAGAAATAGAGTGACAAACTCTGCACTTAAGTCCCCTGTTTCTGTTTAACTTGCAGTGCTTATCACA 1281 GGCCCTTCCTTAATTTTTTAAACAAGGCTGCTTGAGGCTGGGGTAAATTTTGGGGCTTTGGGAGTACACAGGACTACTGA 1361 GGGACGGGGAGTTGGTGGCTTGGTGTTCATGGTGGAGACTTGGTTCTTTACGCAGAGCAGGCTAAAGGCGTGTTTTTTCT 1441 GCTCTGTTTCTAATTCATGTTAAGTAGTTGGTCATCACTTTGGTCAGAGCTGCTGCTGAAGCTCTCTTAACTGTGAGTCA 1521 CTGGACGTTGGCAGGGAGTTGGCTGTGAGATTGTAGGTGCTCAAGTGTTTCTGTTCGGGACTGAGTGTGAATCTGTAAAA 1601 GGGGAAAATCCTCGCAAGAGGTCTACGAGAAGGATGAGGGCCCAAGTCTAGGGTCTAAACAAAGCCAGGAGTGGTTTGGT 1681 ATATTACTGAGTGCAATCATTGCGTGCCATTCCTGCACTCAATGTATTGTGTAAAATCCTTAGGTAAAATGGGATAAACC 1761 CACAGCTGGTCCTACTTGGCCTCTTGAAAACCATTCCATCATTGTGCCAATCTAGCCTGAAAAGG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | LCL-BAC | ||||||
Disease | MIMAT0027405 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1020023. RNA binding protein: AGO2. Condition:EBV B95-8-infected
... - Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Skalsky RL; Corcoran DL; Gottwein E; Frank et al. - PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
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CLIP-seq Support 1 for dataset GSM1020023 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | LCL-BAC / EBV B95-8-infected, 4-thiouridine, RNase T1 |
Location of target site | ENST00000395176.2 | 3UTR | UUGGCAGGGAGUUGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22291592 / GSE41437 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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110 hsa-miR-6752-3p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT152341 | TNFSF9 | TNF superfamily member 9 | 2 | 2 | ||||||||
MIRT273594 | SP1 | Sp1 transcription factor | 2 | 2 | ||||||||
MIRT291927 | TPM4 | tropomyosin 4 | 2 | 4 | ||||||||
MIRT311186 | ANKRD33B | ankyrin repeat domain 33B | 2 | 4 | ||||||||
MIRT378521 | CDKN1A | cyclin dependent kinase inhibitor 1A | 2 | 4 | ||||||||
MIRT452467 | SORCS2 | sortilin related VPS10 domain containing receptor 2 | 2 | 2 | ||||||||
MIRT478636 | CTDNEP1 | CTD nuclear envelope phosphatase 1 | 2 | 2 | ||||||||
MIRT496343 | TMEM81 | transmembrane protein 81 | 2 | 2 | ||||||||
MIRT496646 | MFAP3 | microfibril associated protein 3 | 2 | 2 | ||||||||
MIRT496711 | DNAJC30 | DnaJ heat shock protein family (Hsp40) member C30 | 2 | 2 | ||||||||
MIRT499242 | VAV3 | vav guanine nucleotide exchange factor 3 | 2 | 4 | ||||||||
MIRT519777 | ZNF354B | zinc finger protein 354B | 2 | 6 | ||||||||
MIRT520883 | STX17 | syntaxin 17 | 2 | 2 | ||||||||
MIRT522476 | ZAK | mitogen-activated protein kinase kinase kinase 20 | 2 | 2 | ||||||||
MIRT523587 | G3BP2 | G3BP stress granule assembly factor 2 | 2 | 6 | ||||||||
MIRT525240 | KCNJ12 | potassium voltage-gated channel subfamily J member 12 | 2 | 2 | ||||||||
MIRT527025 | PABPN1L | poly(A) binding protein nuclear 1 like, cytoplasmic | 2 | 2 | ||||||||
MIRT527709 | IL17REL | interleukin 17 receptor E like | 2 | 2 | ||||||||
MIRT530778 | GPD1 | glycerol-3-phosphate dehydrogenase 1 | 2 | 2 | ||||||||
MIRT531883 | SCN1B | sodium voltage-gated channel beta subunit 1 | 2 | 2 | ||||||||
MIRT533043 | ZBTB46 | zinc finger and BTB domain containing 46 | 2 | 2 | ||||||||
MIRT535062 | PPP2R5D | protein phosphatase 2 regulatory subunit B'delta | 2 | 4 | ||||||||
MIRT536512 | KCTD15 | potassium channel tetramerization domain containing 15 | 2 | 2 | ||||||||
MIRT543793 | RALGAPB | Ral GTPase activating protein non-catalytic beta subunit | 2 | 2 | ||||||||
MIRT563977 | HCFC1 | host cell factor C1 | 2 | 2 | ||||||||
MIRT569472 | MAN2A2 | mannosidase alpha class 2A member 2 | 2 | 2 | ||||||||
MIRT570600 | NFIX | nuclear factor I X | 2 | 2 | ||||||||
MIRT571402 | MED4 | mediator complex subunit 4 | 2 | 2 | ||||||||
MIRT608418 | PPIC | peptidylprolyl isomerase C | 2 | 6 | ||||||||
MIRT608928 | REXO2 | RNA exonuclease 2 | 2 | 4 | ||||||||
MIRT609357 | ZNF664 | zinc finger protein 664 | 2 | 2 | ||||||||
MIRT611189 | WBSCR17 | polypeptide N-acetylgalactosaminyltransferase 17 | 2 | 4 | ||||||||
MIRT615266 | DPF2 | double PHD fingers 2 | 2 | 2 | ||||||||
MIRT615408 | VDAC2 | voltage dependent anion channel 2 | 2 | 2 | ||||||||
MIRT616323 | AGO3 | argonaute 3, RISC catalytic component | 2 | 2 | ||||||||
MIRT616566 | ZNF512B | zinc finger protein 512B | 2 | 2 | ||||||||
MIRT616745 | TAZ | tafazzin | 2 | 2 | ||||||||
MIRT617316 | MBOAT1 | membrane bound O-acyltransferase domain containing 1 | 2 | 2 | ||||||||
MIRT620030 | NFAM1 | NFAT activating protein with ITAM motif 1 | 2 | 2 | ||||||||
MIRT621166 | RTTN | rotatin | 2 | 2 | ||||||||
MIRT623501 | KCNQ3 | potassium voltage-gated channel subfamily Q member 3 | 2 | 2 | ||||||||
MIRT623524 | KCNK10 | potassium two pore domain channel subfamily K member 10 | 2 | 2 | ||||||||
MIRT629683 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | 2 | 2 | ||||||||
MIRT630795 | TGIF2 | TGFB induced factor homeobox 2 | 2 | 2 | ||||||||
MIRT634638 | HIP1 | huntingtin interacting protein 1 | 2 | 4 | ||||||||
MIRT636788 | RAB40B | RAB40B, member RAS oncogene family | 2 | 2 | ||||||||
MIRT640332 | DAAM2 | dishevelled associated activator of morphogenesis 2 | 2 | 2 | ||||||||
MIRT640557 | SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | 2 | 2 | ||||||||
MIRT643319 | TMEM151B | transmembrane protein 151B | 2 | 2 | ||||||||
MIRT643991 | DUSP28 | dual specificity phosphatase 28 | 2 | 2 | ||||||||
MIRT644618 | CD300E | CD300e molecule | 2 | 2 | ||||||||
MIRT646445 | XRCC2 | X-ray repair cross complementing 2 | 2 | 2 | ||||||||
MIRT648020 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | 2 | 2 | ||||||||
MIRT648077 | ZMIZ2 | zinc finger MIZ-type containing 2 | 2 | 2 | ||||||||
MIRT649618 | ITPKC | inositol-trisphosphate 3-kinase C | 2 | 2 | ||||||||
MIRT650414 | ZNF442 | zinc finger protein 442 | 2 | 2 | ||||||||
MIRT650850 | SEMA4G | semaphorin 4G | 2 | 2 | ||||||||
MIRT654694 | PSMB5 | proteasome subunit beta 5 | 2 | 2 | ||||||||
MIRT655512 | PAIP2B | poly(A) binding protein interacting protein 2B | 2 | 2 | ||||||||
MIRT657620 | GRAP2 | GRB2-related adaptor protein 2 | 2 | 2 | ||||||||
MIRT658009 | GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 2 | 2 | ||||||||
MIRT658329 | FAM83F | family with sequence similarity 83 member F | 2 | 2 | ||||||||
MIRT658832 | SRCAP | Snf2 related CREBBP activator protein | 2 | 2 | ||||||||
MIRT658920 | DPY19L4 | dpy-19 like 4 | 2 | 2 | ||||||||
MIRT661058 | RPL18A | ribosomal protein L18a | 2 | 2 | ||||||||
MIRT662342 | MYLK3 | myosin light chain kinase 3 | 2 | 2 | ||||||||
MIRT663451 | FBXO2 | F-box protein 2 | 2 | 2 | ||||||||
MIRT676752 | SGTB | small glutamine rich tetratricopeptide repeat containing beta | 2 | 4 | ||||||||
MIRT684705 | LRRD1 | leucine rich repeats and death domain containing 1 | 2 | 2 | ||||||||
MIRT687247 | PDHB | pyruvate dehydrogenase E1 beta subunit | 2 | 2 | ||||||||
MIRT693881 | NT5C2 | 5'-nucleotidase, cytosolic II | 2 | 2 | ||||||||
MIRT693922 | HNRNPA1L2 | heterogeneous nuclear ribonucleoprotein A1-like 2 | 2 | 2 | ||||||||
MIRT695921 | ZNF174 | zinc finger protein 174 | 2 | 2 | ||||||||
MIRT702867 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 2 | 2 | ||||||||
MIRT708863 | TMSB4X | thymosin beta 4, X-linked | 2 | 2 | ||||||||
MIRT708936 | CRY2 | cryptochrome circadian clock 2 | 2 | 2 | ||||||||
MIRT709476 | FAXC | failed axon connections homolog | 2 | 2 | ||||||||
MIRT709752 | UBD | ubiquitin D | 2 | 2 | ||||||||
MIRT710128 | VANGL2 | VANGL planar cell polarity protein 2 | 2 | 2 | ||||||||
MIRT710274 | FAM107A | family with sequence similarity 107 member A | 2 | 2 | ||||||||
MIRT711146 | TMEM174 | transmembrane protein 174 | 2 | 2 | ||||||||
MIRT712582 | ATP2B4 | ATPase plasma membrane Ca2+ transporting 4 | 2 | 2 | ||||||||
MIRT712648 | TXNL4A | thioredoxin like 4A | 2 | 2 | ||||||||
MIRT713325 | TMEM44 | transmembrane protein 44 | 2 | 2 | ||||||||
MIRT713413 | PEX16 | peroxisomal biogenesis factor 16 | 2 | 2 | ||||||||
MIRT713891 | RNF19B | ring finger protein 19B | 2 | 2 | ||||||||
MIRT714549 | COL14A1 | collagen type XIV alpha 1 chain | 2 | 2 | ||||||||
MIRT714809 | ARHGEF19 | Rho guanine nucleotide exchange factor 19 | 2 | 2 | ||||||||
MIRT714840 | SCAMP2 | secretory carrier membrane protein 2 | 2 | 2 | ||||||||
MIRT715779 | DDX42 | DEAD-box helicase 42 | 2 | 2 | ||||||||
MIRT715795 | TBL3 | transducin beta like 3 | 2 | 2 | ||||||||
MIRT716088 | RNF150 | ring finger protein 150 | 2 | 2 | ||||||||
MIRT716712 | IMP4 | IMP4, U3 small nucleolar ribonucleoprotein | 2 | 2 | ||||||||
MIRT716737 | APOL6 | apolipoprotein L6 | 2 | 2 | ||||||||
MIRT717069 | MTMR6 | myotubularin related protein 6 | 2 | 2 | ||||||||
MIRT718185 | HLCS | holocarboxylase synthetase | 2 | 2 | ||||||||
MIRT719386 | SECTM1 | secreted and transmembrane 1 | 2 | 2 | ||||||||
MIRT720679 | SLC39A13 | solute carrier family 39 member 13 | 2 | 2 | ||||||||
MIRT721315 | FAM58A | cyclin Q | 2 | 2 | ||||||||
MIRT721396 | LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | 2 | 2 | ||||||||
MIRT721896 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 | 2 | 2 | ||||||||
MIRT722442 | ZBTB7B | zinc finger and BTB domain containing 7B | 2 | 2 | ||||||||
MIRT723009 | FADS1 | fatty acid desaturase 1 | 2 | 2 | ||||||||
MIRT723675 | CTC1 | CST telomere replication complex component 1 | 2 | 2 | ||||||||
MIRT723774 | ROBO4 | roundabout guidance receptor 4 | 2 | 2 | ||||||||
MIRT723814 | OR1L8 | olfactory receptor family 1 subfamily L member 8 | 2 | 2 | ||||||||
MIRT723959 | TMEM184A | transmembrane protein 184A | 2 | 2 | ||||||||
MIRT724449 | OPA3 | OPA3, outer mitochondrial membrane lipid metabolism regulator | 2 | 2 | ||||||||
MIRT724798 | C1D | C1D nuclear receptor corepressor | 2 | 2 | ||||||||
MIRT725626 | CAMKV | CaM kinase like vesicle associated | 2 | 2 |