miRTarBase - #MIRT496778


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pre-miRNA Information
pre-miRNA hsa-mir-637   
Genomic Coordinates chr19: 3961414 - 3961512
Synonyms MIRN637, hsa-mir-637, MIR637
Description Homo sapiens miR-637 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-637
Sequence 61| ACUGGGGGCUUUCGGGCUCUGCGU |84
Evidence Experimental
Experiments SAGE
Expression Profile
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN518997 2 COSMIC
COSN1082357 6 COSMIC
COSN13804010 13 COSMIC
COSN1082358 14 COSMIC
COSN30450169 14 COSMIC
COSN30532059 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1416171403 2 dbSNP
rs200224173 4 dbSNP
rs1475121792 9 dbSNP
rs202144891 13 dbSNP
rs767027646 14 dbSNP
rs529226642 16 dbSNP
rs751534327 17 dbSNP
rs758718359 17 dbSNP
rs149472696 20 dbSNP
rs773105166 21 dbSNP
rs543903246 22 dbSNP
rs374248027 24 dbSNP
Putative Targets

Gene Information
Gene Symbol ADAMTS14   
Synonyms -
Description ADAM metallopeptidase with thrombospondin type 1 motif 14
Transcript NM_080722   
Other Transcripts NM_139155   
Expression
Putative miRNA Targets on ADAMTS14
3'UTR of ADAMTS14
(miRNA target sites are highlighted)		 
>ADAMTS14|NM_080722|3'UTR
   1 GCTGTGCCCTGCCATCCCACTGGCACGTTTACACTCTGTGTACTGCCCCGTGACTCCCAGCTCAGAGGACACACATAGCA
  81 GGGCAGGCGCAAGCACAGACTTCATTTTAAATCATTCGCCTTCTTCTCGTTTGGGGCTGTGATGCTCTTTACCCCACAAA
 161 GCGGGGTGGGAGGAAGACAAAGATCAGGGAAAGCCCTAATCGGAGATACCTCAGCAAGCTGCCCCCGGCGGGACTGACCC
 241 TCTCAGGGCCCCTGTTGGTCTCCCCTGCCAAGACCAGGGTCAACTATTGCTCCCTCCTCACAGACCCTGGGCCTGGGCAG
 321 GTCTGAATCCCGGCTGGTCTGTAGCTAGAAGCTGTCAGGGCTGCCTGCCTTCCCGGAACTGTGAGGACCCCTGTGGAGGC
 401 CCTGCATATTTGGCCCCTCTCCCCAGAAAGGCAAAGCAGGGCCAGGGTAGGTGGGGGACTGTTCACAGCCAGGCCGAGAG
 481 GAGGGGGGCCTGGGAATGTGGCATGAGGCTTCCCAGCTGCAGGGCTGGAGGGGGTGGAACACAAGGTGATCGCAGGCCCA
 561 GCTCCTGGAAGCCAAGAGCTCCATGCAGTTCCACCAGCTGAGGCCAGGCAGCAGAGGCCAGTTTGTCTTTGCTGGCCAGA
 641 AGATGGTGCTCATGGCCATACTCTGGCCTTGCAGATGTCACTAGTGTTACTTCTAGTGACTCCAGATTACAGACTGGCCC
 721 CCCAATCTCACCCCAGCCCACCAGAGAAGGGGGCTCAGGACACCCTGGACCCCAAGTCCTCAGCATCCAGGGATTTCCAA
 801 ACTGGCGCTCACTCCCTGACTCCACCAGGATGGCAACTTCAATTATCACTCTCAGCCTGGAAGGGGACTCTGTGGGACAC
 881 AGAGGGAACACGATTTCTCAGGCTGTCCCTTCAATCATTGCCCTTCTCCGAAGATCGCTCCTGCTGGAGTCGGACATCTT
 961 CATCTTCTACCTGGCTCAAGCTGGGCCAGAGTGTGTGGTTCTCCCAGGGGTGGTTGGACCCCAGGACTGAGGACCAGAGT
1041 CCACTCATAGCCTGGCCCTGGAGATGACAAGGGCCACCCAGGCCAAGTGCCCCAGGGCAGGGTGCCAGCCCCTGGCCTGG
1121 TGCTGGAGTGGGGAAGACACACTCACCCACGGTGCTGTAAGGGCCTGAGCTGTGCTCAGCTGCCGGCCATGCTACCTCCA
1201 AGGGACAGGTAACAGTCTTAGATCCTCTGGCTCTCAGGAAGTGGCAGGGGGTCCCAGGACACCTCCGGGGTCTTGGAGGA
1281 TGTCTCCTAAACTCCTGCCAGGTGATAGAGGTGCTTCTCACTTCTTCCTTCCCCAAGGCAAAGGGGCTGTTCTGAGCCAG
1361 CCTGGAGGAACATGAGTAGTGGGCCCCTGGCCTGCAACCCCTTTGGAGAGTGGAGGTCCTGGGGGGCTCCCCGCCCTCCC
1441 CCTGTTGCCCTCCCCTCCCTGGGATGCTGGGGCACACGCGGAGTCATTCCTGTGAGAACCAGCCTGGCCTGTGTTAAACT
1521 CTTGTGCCTTGGAAATCCAGATCTTTAAAATTTTATGTATTTATTAACATCGCCATTGGACCCCAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugCGUCUCGGGCUUUCGGGGGUCa 5'
            |:|  |||| : : |:||||| 
Target 5' gtGTACTGCCCCGTGACTCCCAGc 3'
 38 - 61 142.00 -21.10
2 
miRNA  3' ugCGUCUCGGGCUUUC-------GGGGGUCa 5'
            || |:||| ||: |       |:||||| 
Target 5' aaGCTGGGCCAGAGTGTGTGGTTCTCCCAGg 3'
 978 - 1008 142.00 -22.20
3 
miRNA  3' ugcGUCUC----GGG-CUUU---CGGGGGUCa 5'
             |:|||    |:| | ||   ||||||:| 
Target 5' aatCGGAGATACCTCAGCAAGCTGCCCCCGGc 3'
 198 - 229 139.00 -23.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30166153 3 COSMIC
COSN30103192 10 COSMIC
COSN28772013 52 COSMIC
COSN31575763 62 COSMIC
COSN31527445 129 COSMIC
COSN18713636 174 COSMIC
COSN28692551 227 COSMIC
COSN31539153 228 COSMIC
COSN21001654 366 COSMIC
COSN23301141 515 COSMIC
COSN1499659 917 COSMIC
COSN28717775 1043 COSMIC
COSN31536985 1074 COSMIC
COSN31960497 1151 COSMIC
COSN28773753 1185 COSMIC
COSN26105698 1187 COSMIC
COSN26552194 1187 COSMIC
COSN26564134 1231 COSMIC
COSN8719430 1259 COSMIC
COSN31527447 1264 COSMIC
COSN20107234 1306 COSMIC
COSN31960498 1340 COSMIC
COSN23530469 1425 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753492425 1 dbSNP
rs761111957 2 dbSNP
rs1206944201 6 dbSNP
rs756991167 15 dbSNP
rs201943793 20 dbSNP
rs373869653 21 dbSNP
rs764929235 25 dbSNP
rs190719563 27 dbSNP
rs758237381 28 dbSNP
rs994770412 33 dbSNP
rs1175868595 34 dbSNP
rs1449842529 37 dbSNP
rs780092296 37 dbSNP
rs1364846359 39 dbSNP
rs752779217 40 dbSNP
rs377015296 43 dbSNP
rs778077632 46 dbSNP
rs1269710611 47 dbSNP
rs749505393 50 dbSNP
rs147698528 51 dbSNP
rs10999519 52 dbSNP
rs1210839742 64 dbSNP
rs1019678825 88 dbSNP
rs1259438186 89 dbSNP
rs1487143752 90 dbSNP
rs1343294363 93 dbSNP
rs1206020384 94 dbSNP
rs1039872930 97 dbSNP
rs1213360069 114 dbSNP
rs1381914624 115 dbSNP
rs11593430 118 dbSNP
rs1450299688 119 dbSNP
rs1201825801 120 dbSNP
rs1413557856 120 dbSNP
rs115532359 121 dbSNP
rs1472279575 122 dbSNP
rs1157056875 123 dbSNP
rs796639517 126 dbSNP
rs1425507480 127 dbSNP
rs41278002 127 dbSNP
rs1454244747 129 dbSNP
rs16927931 130 dbSNP
rs1388282120 137 dbSNP
rs1406587771 138 dbSNP
rs1303338758 139 dbSNP
rs894311439 152 dbSNP
rs1349519302 155 dbSNP
rs1012297296 156 dbSNP
rs573367496 157 dbSNP
rs1317055744 174 dbSNP
rs34193846 187 dbSNP
rs534446244 202 dbSNP
rs916204418 203 dbSNP
rs969067016 206 dbSNP
rs769735322 211 dbSNP
rs1459247636 225 dbSNP
rs41278004 227 dbSNP
rs970874294 227 dbSNP
rs75465280 228 dbSNP
rs567774346 230 dbSNP
rs774153986 231 dbSNP
rs1419911576 239 dbSNP
rs751873228 245 dbSNP
rs1269803827 246 dbSNP
rs761488163 249 dbSNP
rs1175914525 251 dbSNP
rs1489663150 252 dbSNP
rs1247852975 268 dbSNP
rs1482855891 272 dbSNP
rs1213576426 276 dbSNP
rs1175773892 281 dbSNP
rs1333274128 287 dbSNP
rs1269498453 288 dbSNP
rs920426439 295 dbSNP
rs930530842 300 dbSNP
rs1419800954 301 dbSNP
rs1304399990 306 dbSNP
rs1388353757 315 dbSNP
rs2541232 322 dbSNP
rs964568588 324 dbSNP
rs975152108 328 dbSNP
rs922342417 329 dbSNP
rs889056883 332 dbSNP
rs369934403 333 dbSNP
rs45542543 336 dbSNP
rs941236311 337 dbSNP
rs901231671 343 dbSNP
rs7074569 348 dbSNP
rs770237064 353 dbSNP
rs1031106435 355 dbSNP
rs1193338767 359 dbSNP
rs958213910 362 dbSNP
rs1011519273 367 dbSNP
rs113366180 375 dbSNP
rs1013160132 376 dbSNP
rs970083671 377 dbSNP
rs1485248555 381 dbSNP
rs540465110 385 dbSNP
rs1252949152 402 dbSNP
rs1234999997 409 dbSNP
rs1394982780 410 dbSNP
rs754285934 414 dbSNP
rs1302434158 416 dbSNP
rs961749251 424 dbSNP
rs971823368 428 dbSNP
rs906597959 430 dbSNP
rs920396804 435 dbSNP
rs1003606534 443 dbSNP
rs755338369 454 dbSNP
rs1248540434 460 dbSNP
rs986409998 476 dbSNP
rs796595501 477 dbSNP
rs944630964 479 dbSNP
rs1341973851 483 dbSNP
rs1395857421 487 dbSNP
rs558488930 488 dbSNP
rs1202668546 489 dbSNP
rs765544974 494 dbSNP
rs1040984818 495 dbSNP
rs1480978484 498 dbSNP
rs901200556 503 dbSNP
rs1241130448 504 dbSNP
rs1446374831 506 dbSNP
rs752936096 509 dbSNP
rs1052458679 520 dbSNP
rs1408044442 521 dbSNP
rs1172044472 531 dbSNP
rs74437787 532 dbSNP
rs532673837 534 dbSNP
rs1208531759 543 dbSNP
rs2587469 547 dbSNP
rs1298289222 552 dbSNP
rs568931109 553 dbSNP
rs1024257366 554 dbSNP
rs1300575331 563 dbSNP
rs2688769 567 dbSNP
rs1312477035 568 dbSNP
rs1455042026 573 dbSNP
rs1372830736 574 dbSNP
rs113752435 590 dbSNP
rs1364883109 595 dbSNP
rs1371782227 602 dbSNP
rs1213213686 603 dbSNP
rs567202573 605 dbSNP
rs1034658579 614 dbSNP
rs1185302407 620 dbSNP
rs1483806878 624 dbSNP
rs1273474026 628 dbSNP
rs1275320464 636 dbSNP
rs1194955119 641 dbSNP
rs1337372079 647 dbSNP
rs1308313440 653 dbSNP
rs961717754 667 dbSNP
rs1267137649 668 dbSNP
rs1209423828 673 dbSNP
rs75271180 676 dbSNP
rs1027404899 678 dbSNP
rs1462757142 679 dbSNP
rs1038076849 690 dbSNP
rs1413193323 694 dbSNP
rs1352500754 697 dbSNP
rs1204193261 699 dbSNP
rs1247381946 700 dbSNP
rs3740440 701 dbSNP
rs1409748067 709 dbSNP
rs1395041811 712 dbSNP
rs1165483411 713 dbSNP
rs1461543006 718 dbSNP
rs985950879 724 dbSNP
rs561201196 726 dbSNP
rs528295293 733 dbSNP
rs1473376343 741 dbSNP
rs1188067730 743 dbSNP
rs570925433 754 dbSNP
rs1180901691 755 dbSNP
rs1045955683 757 dbSNP
rs1269427047 770 dbSNP
rs368832443 774 dbSNP
rs975985344 778 dbSNP
rs1334009728 789 dbSNP
rs1003552853 790 dbSNP
rs1231461685 792 dbSNP
rs1353196854 793 dbSNP
rs924561549 805 dbSNP
rs935315391 807 dbSNP
rs1432233624 808 dbSNP
rs764351114 813 dbSNP
rs2587468 814 dbSNP
rs893881910 818 dbSNP
rs946798614 819 dbSNP
rs1407632923 825 dbSNP
rs1442307539 828 dbSNP
rs1045194843 841 dbSNP
rs140970405 852 dbSNP
rs1323312208 853 dbSNP
rs1458353049 864 dbSNP
rs1408336613 871 dbSNP
rs377098451 872 dbSNP
rs61851562 884 dbSNP
rs768606660 892 dbSNP
rs1022329491 893 dbSNP
rs372976485 900 dbSNP
rs1193966886 908 dbSNP
rs900073176 931 dbSNP
rs1035255705 937 dbSNP
rs997134100 938 dbSNP
rs778803356 946 dbSNP
rs114484600 947 dbSNP
rs1285264945 948 dbSNP
rs747806532 952 dbSNP
rs771724166 953 dbSNP
rs1306098235 954 dbSNP
rs1235394724 956 dbSNP
rs982488320 957 dbSNP
rs1324454027 958 dbSNP
rs1218853082 965 dbSNP
rs1345304549 972 dbSNP
rs183482365 977 dbSNP
rs1325714038 978 dbSNP
rs1224234153 981 dbSNP
rs188629191 984 dbSNP
rs1453564514 988 dbSNP
rs573117495 996 dbSNP
rs150201549 999 dbSNP
rs966259508 1006 dbSNP
rs760245389 1008 dbSNP
rs1217950861 1011 dbSNP
rs1242477024 1013 dbSNP
rs1445500741 1014 dbSNP
rs192757472 1016 dbSNP
rs777151958 1017 dbSNP
rs924527436 1033 dbSNP
rs948620695 1037 dbSNP
rs532178395 1038 dbSNP
rs544303171 1039 dbSNP
rs3740438 1043 dbSNP
rs1269084156 1051 dbSNP
rs1157791114 1052 dbSNP
rs1357042407 1057 dbSNP
rs1433915692 1061 dbSNP
rs1373426620 1062 dbSNP
rs1172200520 1067 dbSNP
rs1410472715 1082 dbSNP
rs988068585 1088 dbSNP
rs1407808253 1094 dbSNP
rs915227933 1097 dbSNP
rs374603034 1100 dbSNP
rs1250126000 1112 dbSNP
rs946798216 1121 dbSNP
rs868474633 1123 dbSNP
rs1259931083 1127 dbSNP
rs926755921 1130 dbSNP
rs1346135289 1132 dbSNP
rs939480446 1139 dbSNP
rs1278651404 1141 dbSNP
rs138698024 1151 dbSNP
rs898046602 1152 dbSNP
rs1308674444 1156 dbSNP
rs1272911507 1157 dbSNP
rs993753110 1164 dbSNP
rs12413137 1185 dbSNP
rs3740437 1186 dbSNP
rs1029920927 1191 dbSNP
rs891421892 1200 dbSNP
rs1007257640 1203 dbSNP
rs1004374650 1204 dbSNP
rs1015795920 1209 dbSNP
rs1287808192 1236 dbSNP
rs1017755564 1238 dbSNP
rs1464168988 1239 dbSNP
rs562804960 1256 dbSNP
rs1165676371 1261 dbSNP
rs997295277 1267 dbSNP
rs528006490 1268 dbSNP
rs1220004099 1283 dbSNP
rs955915289 1298 dbSNP
rs543214145 1301 dbSNP
rs552568359 1302 dbSNP
rs3832690 1305 dbSNP
rs751787002 1305 dbSNP
rs571030388 1309 dbSNP
rs968439939 1310 dbSNP
rs538403841 1323 dbSNP
rs868035968 1326 dbSNP
rs1332306213 1328 dbSNP
rs1043832226 1329 dbSNP
rs1409388254 1335 dbSNP
rs1424367700 1342 dbSNP
rs1224178841 1344 dbSNP
rs75804961 1345 dbSNP
rs1367926318 1350 dbSNP
rs939424961 1351 dbSNP
rs1405768655 1358 dbSNP
rs569016551 1380 dbSNP
rs1051129059 1395 dbSNP
rs576769152 1399 dbSNP
rs891368171 1400 dbSNP
rs753026201 1407 dbSNP
rs1444498279 1409 dbSNP
rs919444393 1411 dbSNP
rs1286695631 1414 dbSNP
rs117853822 1417 dbSNP
rs1177095872 1421 dbSNP
rs1470220594 1433 dbSNP
rs572714635 1433 dbSNP
rs888060590 1434 dbSNP
rs1007635875 1435 dbSNP
rs1466732701 1441 dbSNP
rs753852419 1442 dbSNP
rs140367175 1443 dbSNP
rs901565321 1443 dbSNP
rs997221056 1448 dbSNP
rs183195940 1449 dbSNP
rs970252243 1450 dbSNP
rs1371714478 1451 dbSNP
rs1302563981 1453 dbSNP
rs1440319625 1459 dbSNP
rs1388709627 1460 dbSNP
rs1181926598 1474 dbSNP
rs1233904488 1478 dbSNP
rs891643419 1479 dbSNP
rs11572 1480 dbSNP
rs1021942439 1481 dbSNP
rs1455842325 1484 dbSNP
rs955938322 1491 dbSNP
rs1193525800 1493 dbSNP
rs1431902011 1501 dbSNP
rs970038731 1508 dbSNP
rs1205137332 1519 dbSNP
rs1485380036 1519 dbSNP
rs1283425716 1521 dbSNP
rs551041793 1525 dbSNP
rs1033683386 1528 dbSNP
rs1167520330 1536 dbSNP
rs757366581 1542 dbSNP
rs1279297305 1549 dbSNP
rs1232024376 1555 dbSNP
rs149017971 1556 dbSNP
rs1411674006 1557 dbSNP
rs1329629867 1558 dbSNP
rs3740435 1559 dbSNP
rs960757200 1564 dbSNP
rs187030767 1572 dbSNP
rs919371903 1573 dbSNP
rs1437011973 1574 dbSNP
rs1376476993 1576 dbSNP
rs3740434 1581 dbSNP
rs985017560 1583 dbSNP
rs1464989747 1588 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BAC
Disease MIMAT0003307
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020023. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugcgucUCGGGCUUUCGGGGGUca 5'
                :||||     :|||||  
Target 5' ----uuGGCCC--CUCUCCCCA-- 3'
 		1 - 16
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020023
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BAC / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000373208.1 | 3UTR | UUGGCCCCUCUCCCCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.57 2.1e-2 -0.593 1.6e-2 13 Click to see details
GSE17306 Multiple myeloma -0.262 3.4e-2 0.064 3.3e-1 49 Click to see details
GSE28544 Breast cancer 0.312 6.9e-2 0.285 8.9e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.305 6.9e-2 -0.250 1.1e-1 25 Click to see details
GSE38226 Liver fibrosis 0.325 7.5e-2 0.147 2.6e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.259 1.4e-1 0.165 2.4e-1 20 Click to see details
GSE32688 Pancreatic cancer 0.183 1.6e-1 0.188 1.5e-1 32 Click to see details
GSE21849 B cell lymphoma -0.153 2.1e-1 -0.115 2.8e-1 29 Click to see details
GSE26953 Aortic valvular endothelial cells 0.162 2.2e-1 0.120 2.9e-1 24 Click to see details
GSE14794 Lymphoblastoid cells -0.08 2.3e-1 -0.084 2.2e-1 90 Click to see details
GSE27834 Pluripotent stem cells -0.168 2.7e-1 -0.024 4.6e-1 16 Click to see details
GSE21687 Ependynoma primary tumors -0.019 4.4e-1 -0.096 2.3e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.019 4.4e-1 -0.096 2.3e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.019 4.4e-1 -0.096 2.3e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.019 4.4e-1 -0.096 2.3e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-637 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006147 SP7 Sp7 transcription factor 3 1
MIRT054906 COL4A1 collagen type IV alpha 1 chain 1 1
MIRT159142 NRBP1 nuclear receptor binding protein 1 2 2
MIRT358526 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT441490 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT443472 ACPP acid phosphatase, prostate 2 2
MIRT464631 UBE4A ubiquitination factor E4A 2 2
MIRT465259 TRIM44 tripartite motif containing 44 2 2
MIRT473975 LRRC58 leucine rich repeat containing 58 2 2
MIRT475168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT477631 EFNA1 ephrin A1 2 2
MIRT480100 CALR calreticulin 2 2
MIRT483504 STMN3 stathmin 3 2 4
MIRT483735 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT483847 UNC5B unc-5 netrin receptor B 2 2
MIRT485973 RTBDN retbindin 2 2
MIRT486616 METTL6 methyltransferase like 6 2 2
MIRT487847 CLSTN1 calsyntenin 1 2 4
MIRT488675 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT489046 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT490612 SLC47A1 solute carrier family 47 member 1 2 4
MIRT490990 USP22 ubiquitin specific peptidase 22 2 2
MIRT492559 PRX periaxin 2 2
MIRT494667 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT495880 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT496778 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT499742 USH1G USH1 protein network component sans 2 4
MIRT500371 ZNF385A zinc finger protein 385A 2 2
MIRT503257 KIF18B kinesin family member 18B 2 2
MIRT504511 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT511940 FAM127B retrotransposon Gag like 8A 2 2
MIRT514606 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT527187 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT532494 HOXA13 homeobox A13 2 2
MIRT533504 TRIM71 tripartite motif containing 71 2 2
MIRT539171 AR androgen receptor 2 2
MIRT542735 RBFOX2 RNA binding protein, fox-1 homolog 2 2 2
MIRT544647 PHF8 PHD finger protein 8 2 4
MIRT546232 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 2
MIRT548372 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT555913 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT565381 TGOLN2 trans-golgi network protein 2 2 2
MIRT568954 RUNX3 runt related transcription factor 3 2 2
MIRT570205 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT573599 CERS1 ceramide synthase 1 2 2
MIRT615364 CCNF cyclin F 2 2
MIRT616102 HOXB5 homeobox B5 2 2
MIRT619127 CD40LG CD40 ligand 2 2
MIRT634968 C8orf17 chromosome 8 open reading frame 17 2 2
MIRT646665 FNBP1 formin binding protein 1 2 2
MIRT649633 RASA4 RAS p21 protein activator 4 2 2
MIRT658443 FAM167B family with sequence similarity 167 member B 2 2
MIRT660237 BMP7 bone morphogenetic protein 7 2 2
MIRT669467 ATL3 atlastin GTPase 3 2 2
MIRT670557 SHISA2 shisa family member 2 2 2
MIRT671035 PCDHB2 protocadherin beta 2 2 2
MIRT684255 TBXA2R thromboxane A2 receptor 2 2
MIRT688619 CYBRD1 cytochrome b reductase 1 3 2
MIRT694346 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT695516 ALPI alkaline phosphatase, intestinal 2 2
MIRT697512 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT700133 RNF144B ring finger protein 144B 2 2
MIRT711667 TRMT5 tRNA methyltransferase 5 2 2
MIRT712156 TAOK1 TAO kinase 1 2 2
MIRT712463 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT720759 FAM193A family with sequence similarity 193 member A 2 2
MIRT731198 AKT1 AKT serine/threonine kinase 1 2 1
MIRT755463 PACS2 phosphofurin acidic cluster sorting protein 2 1 1
MIRT755522 FOXM1 forkhead box M1 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-637 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-miR-637 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive Low Squamous Cell Carcinoma cell line (SCC-11)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-637 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Tivantinib 11494412 NSC758242 resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-637 Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, HCT-116)
hsa-miR-637 Sevoflurane 5206 NSC760367 approved sensitive Low Colorectal Cancer cell line
hsa-mir-637 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-637 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-637 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-637 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-637 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-637 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-637 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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