miRTarBase - #MIRT497190


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pre-miRNA Information
pre-miRNA hsa-mir-6131   
Genomic Coordinates chr5: 10478037 - 10478145
Description Homo sapiens miR-6131 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6131
Sequence 71| GGCUGGUCAGAUGGGAGUG |89
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 11 5 + 10478117 29233923 MiREDiBase
A-to-I 16 5 + 10478122 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs957913380 1 dbSNP
rs996083508 3 dbSNP
rs1304832380 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DUSP18   
Synonyms DSP18, DUSP20, LMWDSP20
Description dual specificity phosphatase 18
Transcript NM_152511   
Expression
Putative miRNA Targets on DUSP18
3'UTR of DUSP18
(miRNA target sites are highlighted)		 
>DUSP18|NM_152511|3'UTR
   1 GCCATCCCACGAGCCCCTGCATTGGAGTCAGAGGTACAGATCTATTGTTGATCTTACACCAAGATCCAAACTTGAACATT
  81 CTACTTTTGTTGATACAGAAAAAAACAGATGATGCCTTTTATGAGCACAAAAAAGAGTTGCTGTAGCTTTTAACTTTATA
 161 ATCCATTTTTTTTAAGATTAAACTAATTGTGAGATGGTGAAGATAAATTTTCTGCCCTGTGAGTGACACTGGCCAGGGGA
 241 TAGGTTGAGGCAGATGGTGCCCAGAAGAAAGAGGGCAGCACCCATTGCACATGGCAGGCCTGGAATCCTGCAGCCCTCCC
 321 CAAAAACAGATTGACCCAGGAATGAATCTGCTACAATTCCACCTCATTCTTTCACACCCAGAGCCAGAGCCTTAAGCATC
 401 ATGGTACCTCTTGCGCTTCTTACAGTGAGTGCCAATCTACTAGATAAATGGCCTTCAGGCAGTGCTCCAGGAATCCTGGG
 481 GGGTCCCAGGCCACCTCTGCTTCCACCTTCACTATAAGTGGCCCAGTTCTGGTTTTCTAGATTGTACTTATGCATAAGAT
 561 AGTTTTTAAAGAAAGCATTCCACTGTGTAAATTTTTTTTTGTCTTTTTTTGAAACTGTCCTGCTCTGTCACCCATCCTAG
 641 AGTGCAGTAGTGTGATCATGGCTCACTGTAGCCACAACCTCTCAGGCTCAAGTGATCCTCTTACCTTAGCCTCCTGCGTG
 721 GCTGGGACTACAGATGTTTGCCACCATGCCCGCCTCATTTTTTTTCTTTTTTTATAGAGATGAGATTTTACTATGTCGCC
 801 CAGACTGGTCTCAAACTCCTGGCCTCAAGCAATCCTCACGCCTCAGCCTCCCAAAGTGTTGATGAGCCACTGTACCCCGA
 881 TACCACTGTATAAAAAATTTAAAAAAAATTGTGAGTGCTATTGTACATGGCAAAGTTTCAAAGAGCTCTTGGCCATCCCT
 961 CACCAAACTTTGGCAAAAGATGGTGTTAGTCCCCTTCTCCAGGGCACATGAGAAAAACAGGCCTAACATCAGGTCTCAGC
1041 GGTTCCTCTCACAGGCCTTGGCTTGGAAGGCTGGAGCTTCGGACCAAGGCCCAGCCCTGTCACCTCCTCTTCATGTGATG
1121 TGGACCCCTGGGAGCATCAGTGTCCTCATCTGTCCAATGACAGCCCTTTTCTCACAGAGTTATTGTGAAGATTCAACAAT
1201 TTCTTGGCATAGTGCCTGGCACATGGTGTGTGCTTAGCGCAAATGGCAGCTCTCATCATGAATGATAGACTCTTTCACCC
1281 TGCTGGTCCCAGGTCGGCACACACATCCCCATAATGGCATTTCTCCTTTCTGTGCACAGCACTTTATTGTTACAAAGTAC
1361 TCTTCCAAAAAGTTACCCTGTGTGTAAAAAAAAAAAAAAAAAAAAATGGTTTAAGTCCTTTCAGACCCTACCTCACAGGA
1441 GGCCTAGACTTAGAGCCTTTTGAGAGCTTCCGTCTTGTTTAATCTAGGTGCAATCTAGAGGTCCTGAAACAAGGAGCACA
1521 GTTCCAGCTTCCCCCAATCACTTCTAAACAGTGACTGCAGCCTTGTTTAGAATCACTATGAAAACCTGCACCCCGGCTGA
1601 CTACTGGGATCCATAAGGGGGCCGTGTCAAAGGGACTAACTAGTGGACTCCATCAGTAGGCCCTGGAATTCAGGATTGTT
1681 CACATCCTCTTGGTGCCAAGGACCTGGCTGAAGACCAGCTCTTCTGATCCAGAGGTTTTCAGCAAACAGCATTTGAAACA
1761 AAAGCACAGCTGCTCTGTTTGACACCAAACTGTGGCTCCAGATTCCAGTAGAAGCCAAATGCTTTTTCTTTTAACAGCTG
1841 GGTGCCTGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCG
1921 AGCTTGCACCATTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCCATCTCAAAAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gugaGGGUAGA---CUGGUCGg 5'
              ||:: ||   ||||||| 
Target 5' aggaCCTGGCTGAAGACCAGCt 3'
 1699 - 1720 147.00 -15.50
2 
miRNA  3' gugaggGUAGACUGGUCgg 5'
                || |||:||||  
Target 5' gagtgaCA-CTGGCCAGgg 3'
 221 - 238 116.00 -13.20
3 
miRNA  3' guGAGGGU---A-GACUGGUCGg 5'
            ||||||   | :|||: ||| 
Target 5' gcCTCCCAAAGTGTTGATGAGCc 3'
 846 - 868 113.00 -20.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13910233 10 COSMIC
COSN30525344 45 COSMIC
COSN30459143 67 COSMIC
COSN508005 98 COSMIC
COSN31503614 110 COSMIC
COSN31580107 162 COSMIC
COSN30676681 166 COSMIC
COSN24381060 173 COSMIC
COSN24297153 174 COSMIC
COSN28744376 174 COSMIC
COSN22687368 240 COSMIC
COSN22232250 454 COSMIC
COSN1260785 1492 COSMIC
COSN20661743 1715 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1243126083 1 dbSNP
rs780536202 4 dbSNP
rs1450102425 7 dbSNP
rs1292051248 8 dbSNP
rs756496468 9 dbSNP
rs371630116 10 dbSNP
rs1011008862 11 dbSNP
rs893879557 13 dbSNP
rs1230588462 17 dbSNP
rs1362394249 18 dbSNP
rs1052420769 21 dbSNP
rs1348072779 21 dbSNP
rs777330023 22 dbSNP
rs1433781963 27 dbSNP
rs1351287772 28 dbSNP
rs758100559 33 dbSNP
rs1428513952 36 dbSNP
rs1368232215 37 dbSNP
rs893125735 39 dbSNP
rs58619343 42 dbSNP
rs78592960 44 dbSNP
rs373502013 45 dbSNP
rs759046552 50 dbSNP
rs759310828 51 dbSNP
rs1045851006 53 dbSNP
rs1362188246 60 dbSNP
rs948975045 77 dbSNP
rs916130083 78 dbSNP
rs1413135500 87 dbSNP
rs1038581128 104 dbSNP
rs111803206 106 dbSNP
rs571380555 106 dbSNP
rs941743916 106 dbSNP
rs532504807 109 dbSNP
rs1263806179 112 dbSNP
rs1046320552 117 dbSNP
rs1333548710 124 dbSNP
rs1440932454 130 dbSNP
rs1279780622 135 dbSNP
rs1425047565 138 dbSNP
rs947939011 143 dbSNP
rs1279394958 144 dbSNP
rs983234091 144 dbSNP
rs1348481510 154 dbSNP
rs1213012466 157 dbSNP
rs1248504133 158 dbSNP
rs747420326 164 dbSNP
rs552648980 165 dbSNP
rs182765470 166 dbSNP
rs1048687783 173 dbSNP
rs2240002 174 dbSNP
rs923133666 174 dbSNP
rs1253650364 175 dbSNP
rs1396125575 187 dbSNP
rs1220002455 189 dbSNP
rs1490149295 209 dbSNP
rs1393615202 212 dbSNP
rs918331297 219 dbSNP
rs1292412845 220 dbSNP
rs1223761339 229 dbSNP
rs1337132867 231 dbSNP
rs529976634 232 dbSNP
rs1438325300 233 dbSNP
rs560958490 237 dbSNP
rs1306449445 238 dbSNP
rs1249559935 239 dbSNP
rs1338774591 240 dbSNP
rs1017575210 244 dbSNP
rs1224512594 250 dbSNP
rs561956840 251 dbSNP
rs1275262067 265 dbSNP
rs1467299609 271 dbSNP
rs1193311360 276 dbSNP
rs1253949672 279 dbSNP
rs1375839709 281 dbSNP
rs370093997 282 dbSNP
rs1191599289 288 dbSNP
rs1373037708 291 dbSNP
rs1404738808 303 dbSNP
rs191779581 310 dbSNP
rs912178934 312 dbSNP
rs987753570 316 dbSNP
rs1476049040 326 dbSNP
rs1167970564 336 dbSNP
rs1401923953 337 dbSNP
rs1459548788 354 dbSNP
rs1346624752 363 dbSNP
rs1324813574 369 dbSNP
rs1394873783 374 dbSNP
rs953733455 377 dbSNP
rs1293306127 397 dbSNP
rs1325759961 399 dbSNP
rs1228136183 406 dbSNP
rs1271996083 408 dbSNP
rs1332771814 414 dbSNP
rs1029184535 415 dbSNP
rs1452314440 423 dbSNP
rs989600900 425 dbSNP
rs527431568 435 dbSNP
rs1470072235 442 dbSNP
rs377191360 448 dbSNP
rs1261536101 449 dbSNP
rs998966511 455 dbSNP
rs907241080 467 dbSNP
rs1400874057 479 dbSNP
rs564589791 482 dbSNP
rs1473947622 483 dbSNP
rs1013072246 484 dbSNP
rs1163699836 484 dbSNP
rs1459161014 485 dbSNP
rs1196934705 493 dbSNP
rs894644226 514 dbSNP
rs1382645575 524 dbSNP
rs544614555 526 dbSNP
rs1358725086 527 dbSNP
rs1353586449 532 dbSNP
rs1479984300 533 dbSNP
rs1187045833 541 dbSNP
rs999534508 544 dbSNP
rs1337194613 552 dbSNP
rs879651012 553 dbSNP
rs1260504453 558 dbSNP
rs754666420 561 dbSNP
rs1207351505 581 dbSNP
rs575598848 582 dbSNP
rs62235876 589 dbSNP
rs1484877285 591 dbSNP
rs1025374090 594 dbSNP
rs1216618584 600 dbSNP
rs1425178437 601 dbSNP
rs908898058 601 dbSNP
rs941580231 601 dbSNP
rs1331419261 603 dbSNP
rs9606762 606 dbSNP
rs895041220 622 dbSNP
rs1454141142 625 dbSNP
rs923051047 631 dbSNP
rs368654453 632 dbSNP
rs1303911074 633 dbSNP
rs931129102 645 dbSNP
rs1313547421 648 dbSNP
rs1361893210 664 dbSNP
rs1287720072 677 dbSNP
rs896949101 678 dbSNP
rs1389824069 681 dbSNP
rs575063869 683 dbSNP
rs1317851345 684 dbSNP
rs150577166 684 dbSNP
rs373265082 684 dbSNP
rs1242812508 685 dbSNP
rs1278692526 688 dbSNP
rs1347766503 694 dbSNP
rs990094155 700 dbSNP
rs1173795931 713 dbSNP
rs41282549 717 dbSNP
rs1031672998 718 dbSNP
rs912247586 736 dbSNP
rs535220293 738 dbSNP
rs985510698 751 dbSNP
rs932286191 752 dbSNP
rs1024383729 763 dbSNP
rs1434023926 765 dbSNP
rs1187117052 766 dbSNP
rs1360908525 766 dbSNP
rs1466309433 774 dbSNP
rs922177113 779 dbSNP
rs1012936241 782 dbSNP
rs1374294299 784 dbSNP
rs1449345120 787 dbSNP
rs566183604 789 dbSNP
rs188894312 791 dbSNP
rs1370718106 797 dbSNP
rs559056017 798 dbSNP
rs1005805888 801 dbSNP
rs1313399124 806 dbSNP
rs1225711664 816 dbSNP
rs376083231 816 dbSNP
rs958208800 819 dbSNP
rs539054014 825 dbSNP
rs868780895 832 dbSNP
rs1047303839 836 dbSNP
rs929005618 838 dbSNP
rs755332513 839 dbSNP
rs978168487 840 dbSNP
rs971203255 846 dbSNP
rs1194130341 847 dbSNP
rs570092289 852 dbSNP
rs368028374 853 dbSNP
rs1427225861 857 dbSNP
rs901492279 861 dbSNP
rs553355078 863 dbSNP
rs1040174478 875 dbSNP
rs184032553 878 dbSNP
rs1012652190 879 dbSNP
rs1324147808 884 dbSNP
rs910403543 885 dbSNP
rs895101162 896 dbSNP
rs550131747 900 dbSNP
rs139004951 901 dbSNP
rs1360463988 908 dbSNP
rs1294226315 909 dbSNP
rs566901409 909 dbSNP
rs1304315222 911 dbSNP
rs1460284113 915 dbSNP
rs1220030167 918 dbSNP
rs1372358170 920 dbSNP
rs567546900 926 dbSNP
rs1171048645 931 dbSNP
rs547276503 941 dbSNP
rs1451311206 955 dbSNP
rs1467835709 959 dbSNP
rs1221996404 961 dbSNP
rs897003052 963 dbSNP
rs527443314 964 dbSNP
rs1484847201 965 dbSNP
rs1185861342 968 dbSNP
rs1420238670 977 dbSNP
rs1383413762 983 dbSNP
rs190940171 985 dbSNP
rs977363174 987 dbSNP
rs1417378806 988 dbSNP
rs370995187 1002 dbSNP
rs890856423 1004 dbSNP
rs1049445520 1009 dbSNP
rs1194361497 1013 dbSNP
rs1480503289 1016 dbSNP
rs932311832 1018 dbSNP
rs1325925779 1019 dbSNP
rs1252306149 1021 dbSNP
rs9609038 1030 dbSNP
rs1357968227 1035 dbSNP
rs1340545637 1040 dbSNP
rs531285897 1041 dbSNP
rs991551600 1042 dbSNP
rs185920559 1048 dbSNP
rs1228593204 1057 dbSNP
rs924136861 1073 dbSNP
rs1291758241 1075 dbSNP
rs978219288 1081 dbSNP
rs1214921866 1083 dbSNP
rs1263850240 1085 dbSNP
rs970869375 1087 dbSNP
rs1185871903 1092 dbSNP
rs1314428676 1095 dbSNP
rs1165224634 1099 dbSNP
rs542599421 1106 dbSNP
rs917990971 1118 dbSNP
rs990877892 1120 dbSNP
rs1160418578 1121 dbSNP
rs1400515962 1121 dbSNP
rs959642714 1123 dbSNP
rs1413531514 1124 dbSNP
rs1310532335 1129 dbSNP
rs114734655 1134 dbSNP
rs1308439390 1138 dbSNP
rs145135259 1142 dbSNP
rs1363650503 1151 dbSNP
rs1285614918 1157 dbSNP
rs998436645 1161 dbSNP
rs961265076 1163 dbSNP
rs1162933267 1164 dbSNP
rs58640678 1171 dbSNP
rs1445310067 1173 dbSNP
rs775755888 1175 dbSNP
rs541276943 1178 dbSNP
rs1208722136 1180 dbSNP
rs901519950 1182 dbSNP
rs374825925 1193 dbSNP
rs1008476578 1199 dbSNP
rs1189822324 1204 dbSNP
rs1231426025 1206 dbSNP
rs1469854160 1207 dbSNP
rs370605383 1208 dbSNP
rs888832950 1216 dbSNP
rs1054203156 1218 dbSNP
rs1049951541 1222 dbSNP
rs996581534 1225 dbSNP
rs1251640157 1226 dbSNP
rs924450216 1228 dbSNP
rs9606761 1231 dbSNP
rs1352374909 1232 dbSNP
rs1054033668 1233 dbSNP
rs373828068 1238 dbSNP
rs936955524 1239 dbSNP
rs1489986972 1255 dbSNP
rs1231917252 1261 dbSNP
rs1302612411 1268 dbSNP
rs1291698148 1270 dbSNP
rs1202217104 1274 dbSNP
rs949948572 1275 dbSNP
rs1437452493 1280 dbSNP
rs924189206 1288 dbSNP
rs1240344047 1293 dbSNP
rs1193513400 1295 dbSNP
rs1356424414 1296 dbSNP
rs1479316567 1298 dbSNP
rs917251872 1304 dbSNP
rs181287363 1305 dbSNP
rs8630 1309 dbSNP
rs958691621 1329 dbSNP
rs1334822615 1332 dbSNP
rs1402141511 1335 dbSNP
rs1438483200 1336 dbSNP
rs556329536 1338 dbSNP
rs536602349 1347 dbSNP
rs984205770 1349 dbSNP
rs1411432989 1352 dbSNP
rs1268492454 1353 dbSNP
rs1343478966 1363 dbSNP
rs752605804 1375 dbSNP
rs1302456105 1379 dbSNP
rs1376644295 1384 dbSNP
rs1304393986 1385 dbSNP
rs3067260 1386 dbSNP
rs1156930178 1395 dbSNP
rs549480509 1398 dbSNP
rs868714994 1401 dbSNP
rs1412994071 1402 dbSNP
rs1184705247 1404 dbSNP
rs386395203 1406 dbSNP
rs918056035 1406 dbSNP
rs1391273646 1407 dbSNP
rs1425291282 1407 dbSNP
rs1459591452 1407 dbSNP
rs1491130046 1407 dbSNP
rs33914926 1407 dbSNP
rs77182933 1407 dbSNP
rs1387905236 1408 dbSNP
rs1488927444 1409 dbSNP
rs1025780866 1410 dbSNP
rs1193729059 1411 dbSNP
rs1264778655 1413 dbSNP
rs1474021177 1422 dbSNP
rs1163646136 1432 dbSNP
rs190122162 1436 dbSNP
rs540145024 1437 dbSNP
rs965578654 1438 dbSNP
rs1420288901 1444 dbSNP
rs955979854 1447 dbSNP
rs1263855606 1466 dbSNP
rs1353649002 1470 dbSNP
rs919948525 1471 dbSNP
rs113483027 1472 dbSNP
rs1054636528 1473 dbSNP
rs1237296594 1473 dbSNP
rs1260556649 1487 dbSNP
rs999935336 1493 dbSNP
rs1453880231 1496 dbSNP
rs1219521451 1497 dbSNP
rs144406312 1502 dbSNP
rs1041512921 1506 dbSNP
rs1180876246 1510 dbSNP
rs1256464040 1511 dbSNP
rs1202864452 1532 dbSNP
rs771497337 1533 dbSNP
rs961318449 1537 dbSNP
rs917199305 1541 dbSNP
rs1440163644 1542 dbSNP
rs747410659 1550 dbSNP
rs1160397904 1553 dbSNP
rs773642436 1554 dbSNP
rs1055637636 1557 dbSNP
rs937367910 1561 dbSNP
rs1008111179 1570 dbSNP
rs955398354 1573 dbSNP
rs1308987156 1576 dbSNP
rs1229909934 1584 dbSNP
rs1028135735 1588 dbSNP
rs1282441930 1589 dbSNP
rs116386177 1594 dbSNP
rs892876631 1595 dbSNP
rs1208783904 1597 dbSNP
rs1332784100 1603 dbSNP
rs1054085204 1621 dbSNP
rs186145267 1623 dbSNP
rs1237277725 1624 dbSNP
rs1440101033 1627 dbSNP
rs533761206 1640 dbSNP
rs1393158873 1642 dbSNP
rs1432572629 1652 dbSNP
rs376458022 1654 dbSNP
rs951470764 1658 dbSNP
rs918750444 1672 dbSNP
rs976883011 1677 dbSNP
rs141040023 1683 dbSNP
rs1468483021 1697 dbSNP
rs902814928 1700 dbSNP
rs1367496234 1705 dbSNP
rs1043038581 1708 dbSNP
rs1007129323 1714 dbSNP
rs1301272979 1722 dbSNP
rs181701741 1727 dbSNP
rs76352804 1729 dbSNP
rs1479255068 1733 dbSNP
rs1257066179 1741 dbSNP
rs1000356204 1743 dbSNP
rs1240866344 1747 dbSNP
rs1055280041 1748 dbSNP
rs938122936 1759 dbSNP
rs562602773 1765 dbSNP
rs548706853 1766 dbSNP
rs1488115774 1769 dbSNP
rs920000791 1778 dbSNP
rs1193175592 1780 dbSNP
rs1269484231 1783 dbSNP
rs1426840322 1788 dbSNP
rs1464036508 1795 dbSNP
rs1424571727 1798 dbSNP
rs974114686 1805 dbSNP
rs1248157578 1818 dbSNP
rs1349666584 1819 dbSNP
rs1014082792 1828 dbSNP
rs202024432 1829 dbSNP
rs200849606 1833 dbSNP
rs199884774 1834 dbSNP
rs895636760 1834 dbSNP
rs11325761 1835 dbSNP
rs398101724 1835 dbSNP
rs9609037 1840 dbSNP
rs1220160601 1841 dbSNP
rs1346956994 1843 dbSNP
rs908515442 1848 dbSNP
rs1320906141 1856 dbSNP
rs1222157812 1863 dbSNP
rs1268343135 1867 dbSNP
rs1487293687 1870 dbSNP
rs937233624 1881 dbSNP
rs987141936 1884 dbSNP
rs1478884832 1885 dbSNP
rs1365997614 1886 dbSNP
rs955301597 1890 dbSNP
rs1406348410 1894 dbSNP
rs1048349534 1898 dbSNP
rs1028605503 1899 dbSNP
rs930057822 1900 dbSNP
rs1419685236 1903 dbSNP
rs975267632 1904 dbSNP
rs1322696353 1911 dbSNP
rs918712548 1915 dbSNP
rs190148042 1919 dbSNP
rs1405635289 1920 dbSNP
rs1282094478 1921 dbSNP
rs1378124729 1922 dbSNP
rs1335190855 1925 dbSNP
rs1291826152 1927 dbSNP
rs1416512339 1928 dbSNP
rs1417883519 1930 dbSNP
rs1351410116 1931 dbSNP
rs1032723119 1932 dbSNP
rs1215809505 1933 dbSNP
rs766654414 1935 dbSNP
rs965559343 1936 dbSNP
rs998524480 1937 dbSNP
rs1167818975 1939 dbSNP
rs1450679780 1940 dbSNP
rs148129737 1943 dbSNP
rs985722490 1948 dbSNP
rs187497355 1951 dbSNP
rs1459656233 1952 dbSNP
rs1236539865 1955 dbSNP
rs1439551240 1955 dbSNP
rs1159801148 1958 dbSNP
rs1360553433 1959 dbSNP
rs958275306 1962 dbSNP
rs1331679177 1963 dbSNP
rs1358198822 1967 dbSNP
rs1448381764 1967 dbSNP
rs1210471553 1971 dbSNP
rs1374398120 1972 dbSNP
rs1443918642 1975 dbSNP
rs146820373 1977 dbSNP
rs1195127809 1978 dbSNP
rs1342826777 1981 dbSNP
rs1299860426 1982 dbSNP
rs1278077720 1983 dbSNP
rs1443210536 1985 dbSNP
rs572758556 1987 dbSNP
rs878868331 1987 dbSNP
rs978485848 1988 dbSNP
rs1243872942 1989 dbSNP
rs1382208654 1990 dbSNP
rs967446995 1992 dbSNP
rs1020017031 1993 dbSNP
rs1403799881 1993 dbSNP
rs1414622432 1993 dbSNP
rs1491057586 1993 dbSNP
rs375019336 1993 dbSNP
rs397723342 1993 dbSNP
rs555969142 1993 dbSNP
rs56242112 1993 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL35
Disease MIMAT0024615
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020022. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020022
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL35 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000403268.1 | 3UTR | UCAAGUGUUCGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
212 hsa-miR-6131 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT077630 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 6
MIRT177175 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT442431 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 6
MIRT478684 CSRP2 cysteine and glycine rich protein 2 2 4
MIRT484891 ZNF607 zinc finger protein 607 2 2
MIRT487161 IFRD1 interferon related developmental regulator 1 2 10
MIRT488196 MAT1A methionine adenosyltransferase 1A 2 2
MIRT495470 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT497190 DUSP18 dual specificity phosphatase 18 2 2
MIRT498387 LRRC58 leucine rich repeat containing 58 2 2
MIRT499716 PAGR1 PAXIP1 associated glutamate rich protein 1 2 10
MIRT507261 FERMT2 fermitin family member 2 2 2
MIRT507290 FEM1B fem-1 homolog B 2 2
MIRT507537 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 6
MIRT508063 ARHGAP42 Rho GTPase activating protein 42 2 4
MIRT510064 C12orf49 chromosome 12 open reading frame 49 2 4
MIRT510825 SBNO1 strawberry notch homolog 1 2 4
MIRT511209 LNPEP leucyl and cystinyl aminopeptidase 2 4
MIRT511827 H2AFX H2A histone family member X 2 4
MIRT512063 DEK DEK proto-oncogene 2 6
MIRT513501 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 6
MIRT513634 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT515274 NUCB1 nucleobindin 1 2 6
MIRT519380 FKBP14 FK506 binding protein 14 2 4
MIRT519521 ZNF8 zinc finger protein 8 2 2
MIRT520633 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT520952 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT522073 ORAI2 ORAI calcium release-activated calcium modulator 2 2 4
MIRT527844 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT530067 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT530226 ZMAT4 zinc finger matrin-type 4 2 2
MIRT530637 PPIC peptidylprolyl isomerase C 2 4
MIRT530677 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531681 MYO3A myosin IIIA 2 2
MIRT532175 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534235 SLC25A16 solute carrier family 25 member 16 2 4
MIRT535116 PLXNA2 plexin A2 2 2
MIRT535562 OMD osteomodulin 2 2
MIRT536483 KIAA1468 KIAA1468 2 2
MIRT538368 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT550667 TRAF1 TNF receptor associated factor 1 2 2
MIRT554736 RHOC ras homolog family member C 2 2
MIRT556522 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT559269 BAG4 BCL2 associated athanogene 4 2 2
MIRT560957 FAM35A family with sequence similarity 35 member A 2 2
MIRT564728 ZNF268 zinc finger protein 268 2 2
MIRT573116 NUBP1 nucleotide binding protein 1 2 2
MIRT573891 MKI67 marker of proliferation Ki-67 2 2
MIRT576641 Mill2 MHC I like leukocyte 2 1 1
MIRT615883 FBXO17 F-box protein 17 2 2
MIRT618203 C22orf39 chromosome 22 open reading frame 39 2 2
MIRT620108 HARBI1 harbinger transposase derived 1 2 2
MIRT621185 FAM153B family with sequence similarity 153 member B 2 2
MIRT621573 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT623753 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT624057 EIF4E eukaryotic translation initiation factor 4E 2 2
MIRT625013 TMIGD2 transmembrane and immunoglobulin domain containing 2 2 2
MIRT626071 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT627872 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT629302 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT629862 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630442 IDE insulin degrading enzyme 2 2
MIRT630997 ZNF573 zinc finger protein 573 2 2
MIRT631091 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT631280 SGSM1 small G protein signaling modulator 1 2 2
MIRT631528 MYO6 myosin VI 2 2
MIRT631641 WDR91 WD repeat domain 91 2 4
MIRT631822 TMEM154 transmembrane protein 154 2 2
MIRT632776 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT633277 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT633655 SLC28A1 solute carrier family 28 member 1 2 2
MIRT634070 PLIN3 perilipin 3 2 2
MIRT634155 YME1L1 YME1 like 1 ATPase 2 2
MIRT634224 TMEM132B transmembrane protein 132B 2 2
MIRT636400 MYO5A myosin VA 2 2
MIRT638677 GCLM glutamate-cysteine ligase modifier subunit 2 2
MIRT638736 FAXC failed axon connections homolog 2 2
MIRT640229 TOMM40 translocase of outer mitochondrial membrane 40 2 2
MIRT640302 PRR13 proline rich 13 2 2
MIRT641123 NPHP3 nephrocystin 3 2 2
MIRT643418 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT644310 NFKBID NFKB inhibitor delta 2 2
MIRT644343 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT645734 POLR3A RNA polymerase III subunit A 2 2
MIRT648055 TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit 2 2
MIRT649461 UBA5 ubiquitin like modifier activating enzyme 5 2 2
MIRT650006 KLB klotho beta 2 2
MIRT650565 YIPF4 Yip1 domain family member 4 2 2
MIRT652638 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT653886 SGK3 serum/glucocorticoid regulated kinase family member 3 2 2
MIRT655365 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT659113 DENND6A DENN domain containing 6A 2 2
MIRT659516 CHST3 carbohydrate sulfotransferase 3 2 2
MIRT659945 C8orf44-SGK3 C8orf44-SGK3 readthrough 2 2
MIRT661382 RHCG Rh family C glycoprotein 2 2
MIRT663106 NPR1 natriuretic peptide receptor 1 2 2
MIRT663756 ZNF285 zinc finger protein 285 2 2
MIRT664553 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT666191 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT666793 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT668751 DDX19B DEAD-box helicase 19B 2 2
MIRT669600 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669703 AAK1 AP2 associated kinase 1 2 2
MIRT669922 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT670002 GPR156 G protein-coupled receptor 156 2 4
MIRT670047 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670296 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670385 EMP2 epithelial membrane protein 2 2 2
MIRT670566 GLTP glycolipid transfer protein 2 2
MIRT671059 KIF1B kinesin family member 1B 2 2
MIRT671080 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT671303 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT671803 WISP3 WNT1 inducible signaling pathway protein 3 2 2
MIRT671954 SPPL3 signal peptide peptidase like 3 2 2
MIRT671991 OSTF1 osteoclast stimulating factor 1 2 2
MIRT672090 WDR5B WD repeat domain 5B 2 2
MIRT672269 SHE Src homology 2 domain containing E 2 2
MIRT672445 TTPAL alpha tocopherol transfer protein like 2 2
MIRT672450 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT673649 CYCS cytochrome c, somatic 2 2
MIRT673998 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674052 ATXN3 ataxin 3 2 2
MIRT674243 NUP62 nucleoporin 62 2 2
MIRT674433 MIOX myo-inositol oxygenase 2 4
MIRT674474 BCL2L15 BCL2 like 15 2 2
MIRT675467 NUBPL nucleotide binding protein like 2 2
MIRT675666 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT675976 FAM126B family with sequence similarity 126 member B 2 2
MIRT676063 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT676118 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT676237 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT676256 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676321 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT676739 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT676903 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT677112 SS18L1 SS18L1, nBAF chromatin remodeling complex subunit 2 2
MIRT677321 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677460 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677578 TRIM65 tripartite motif containing 65 2 2
MIRT677642 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT677735 MOB4 MOB family member 4, phocein 2 2
MIRT677828 TSPYL1 TSPY like 1 2 2
MIRT678078 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678137 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT678157 ZNF724P zinc finger protein 724 2 2
MIRT678255 FXN frataxin 2 2
MIRT678321 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678414 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678596 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT678826 PDE6A phosphodiesterase 6A 2 2
MIRT678939 MYADM myeloid associated differentiation marker 2 2
MIRT679045 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT679200 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT679204 FAM9B family with sequence similarity 9 member B 2 2
MIRT679219 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679251 ZNF34 zinc finger protein 34 2 2
MIRT679315 NPHP1 nephrocystin 1 2 2
MIRT679484 CYTIP cytohesin 1 interacting protein 2 2
MIRT679550 LIPG lipase G, endothelial type 2 2
MIRT679624 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT679646 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT679757 TLR6 toll like receptor 6 2 2
MIRT680123 ZNF576 zinc finger protein 576 2 2
MIRT680183 ZNF554 zinc finger protein 554 2 2
MIRT685770 ZNF426 zinc finger protein 426 2 2
MIRT687438 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688384 ENAH ENAH, actin regulator 2 2
MIRT689668 RBM23 RNA binding motif protein 23 2 2
MIRT690030 CCDC90B coiled-coil domain containing 90B 2 2
MIRT691060 CRCP CGRP receptor component 2 2
MIRT691444 CXorf36 chromosome X open reading frame 36 2 2
MIRT691544 FLYWCH2 FLYWCH family member 2 2 2
MIRT691725 LARS leucyl-tRNA synthetase 2 2
MIRT692632 SUSD1 sushi domain containing 1 2 2
MIRT693822 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT693861 IYD iodotyrosine deiodinase 2 2
MIRT693974 ZNF70 zinc finger protein 70 2 2
MIRT694143 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT695485 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695542 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695598 TMEM199 transmembrane protein 199 2 2
MIRT696001 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT696017 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT696309 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT696397 CORO7 coronin 7 2 2
MIRT696594 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698043 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT698136 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT698287 TMEM2 transmembrane protein 2 2 2
MIRT702556 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT703017 HEATR5A HEAT repeat containing 5A 2 2
MIRT705116 C4orf29 abhydrolase domain containing 18 2 2
MIRT706301 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT706609 CYB5B cytochrome b5 type B 2 2
MIRT706725 RFK riboflavin kinase 2 2
MIRT708651 LYRM7 LYR motif containing 7 2 2
MIRT710149 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT710519 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT711263 CYB561A3 cytochrome b561 family member A3 2 2
MIRT711872 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT714282 KIF1C kinesin family member 1C 2 2
MIRT716605 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT720435 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT720611 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT720615 PIANP PILR alpha associated neural protein 2 2
MIRT722155 ARHGAP40 Rho GTPase activating protein 40 2 2
MIRT722287 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT722754 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723294 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT723839 IL7R interleukin 7 receptor 2 2
MIRT724379 NEK8 NIMA related kinase 8 2 2
MIRT725335 NEUROD1 neuronal differentiation 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6131 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-6131 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6131 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (mitochondrial RNA)
hsa-miR-6131 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-6131 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6131 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-6131 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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