miRTarBase - #MIRT497228


—
pre-miRNA Information
pre-miRNA hsa-mir-3675   
Genomic Coordinates chr1: 16858949 - 16859021
Description Homo sapiens miR-3675 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3675-5p
Sequence 12| UAUGGGGCUUCUGUAGAGAUUUC |34
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1229940041 1 dbSNP
rs1184422098 2 dbSNP
rs768029583 3 dbSNP
rs202014433 6 dbSNP
rs774834919 7 dbSNP
rs1484376029 8 dbSNP
rs771338088 8 dbSNP
rs749521347 10 dbSNP
rs773421450 12 dbSNP
rs1250672393 14 dbSNP
rs769780471 15 dbSNP
rs781028022 16 dbSNP
rs1315377622 17 dbSNP
rs754885466 18 dbSNP
rs746860289 20 dbSNP
rs1330333643 23 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MORC2   
Synonyms CMT2Z, ZCW3, ZCWCC1
Description MORC family CW-type zinc finger 2
Transcript NM_014941   
Expression
Putative miRNA Targets on MORC2
3'UTR of MORC2
(miRNA target sites are highlighted)		 
>MORC2|NM_014941|3'UTR
   1 AGGCAGGAGAGAGAGCAGCTCCCCTGCCCACCTGCCCCTCAACCCTGTAGCTGCAGGGGGAGGGGACTTCATTCATGGGT
  81 TGGTGGTCGCACCTTGGTTTGACTTACACGGGACATTTGTGTTTTTGGAGGAAAAGATACCCTGATTCTTTGAATCTTCC
 161 TTAAGTTTATAAATATTTATTTTTTAAAAGAAGATGCTGTGCCTGTGAGACCATACTTTTTTTTTTTTTTTTTTTTTTTT
 241 TTTTTTTTTTTTGGTGACTGCAAAGGACAGAGAACCTTTCCACTTTGGCCATACTGGGTTGCTAAGCCGGAGCCATTTCA
 321 GCTCCTGGCTCCTCAAGATAACGGCGAGTCCAGTGCCATCTTGGAGAAGCTCCAGGGGCAGGGCTGACTTTTCTCCTACA
 401 GGAGGAACAATGTGGGGATCTGAGGGATGGGAGGGAGACTTCCCCCTAGAGTGGTGGTCCTGCTGGGGGCTCATATCCAG
 481 GGACCCAAAAGGGGGGCTGTGTAGGAGGTTCCACATTGGAGGGGCTCTCTCTCTCGCAGCTGTCAGAGTTGGTCCTGGCT
 561 GTGGCGTCCAAACAGCTTGAGGGAAAAAGATCCTGTCTAACCACCTCATCTACTACTCAAGTTCTTTCTGAAGGAGGGAT
 641 TTCTTCAGTTAACCATGGACAGTGAGGTTTCTCACCACAGTAACTTGAGTCCAGGTTGAGGGGGAGACAGATCTGTGGTA
 721 AATCTCTGACTTGGGCAGCACACTGAGTGTGGAACCCCACAGGACTCCTTAGGGAAGGAGCTTGTGTGTGAAAGAACCCC
 801 TGGGGCTGAGCTGGTGACCTCCATGTGTGGGTGCAGCAGGGCCTTGGATGGTGCCAATTGATCTGGACAGCCTGTTGATG
 881 CTTTTCTACTTCCACCCTTCGGCCTGGCCCCACTGAGCCCCATCAAGGTGCCTGAAGAGGGGGCCAGTGAGATCCCGTGG
 961 CCACAGGGACTCCAGAGGCATCTCTGCAGGAAGCACACCATGCCTTCCCTCCATGTTCCATCACGGCGCCACAATCTGTG
1041 TCCCTTAACTTCTCAGGGTCAAAGACAAAGGCAAGCGTTGCTGAATTTTCTCTTTAATGGCCATTGGAAGAGTCTGGTTC
1121 AGTTTTTCCCAACTCTCTTCCCACTCGTATTTGGGGCCTCTGGGTTTTCTGAAGGCACAAGGACTGTGACTTTGTACCAC
1201 TAACCTGTGGTTCAAACCTGGGTGTGTTTCTGGCATCTCCCTAACCCAGATCAGCAATGGCCACCCTGCTCCTCTGAGGT
1281 CAGCAGAAGACTGGGAAGCAGAGGTGAGGGATGCAGGCCACACTGGAATGGGAAGTCTTTTCCCCACTGGATGTGCCTGT
1361 CTGGTGGGTTTTGGACCTTCCCAGACTACATCTCTAGGAGAGGCCTGTTTGGAGTAGTACACTGAGAGACCCTGGCCTCT
1441 TCTGCTGGAAGACTGTCCAAGTCTTGGGGTTTCTTGAGCTGGTGATTCCTCTGCCATCCTGCTCTCTCTCTTCATCTCAG
1521 GCAGCATGGGGTCCACTTTTGTCCCCAAACCTAATGTTTTAATCCAAATGCAAATTGGTTCCACATTTTTACTGGAGGGT
1601 AATCAGTTTTTAAAATTCACACACATGTAATCGAAACGCAATACTATAAAGTTCTACTGGTGAGACTCCTGAAAAAAAAA
1681 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuuuaGAGAUGUCUUCGGGGUAu 5'
               | | || | |||||||| 
Target 5' cctggCCCCACTG-AGCCCCATc 3'
 903 - 924 153.00 -13.70
2 
miRNA  3' cuuUAGAGAUGUCUUCGGGGUau 5'
             |||| |: ||||||:|||  
Target 5' gccATCT-TGGAGAAGCTCCAgg 3'
 355 - 376 139.00 -18.20
3 
miRNA  3' cuuUAGAGAUGU-CUUCG-G-GGUAu 5'
             ||||||:|| ||||| | |||| 
Target 5' ggcATCTCTGCAGGAAGCACACCATg 3'
 977 - 1002 124.00 -24.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1197030 57 ClinVar
COSN31555480 6 COSMIC
COSN26984901 7 COSMIC
COSN30127555 27 COSMIC
COSN30477402 40 COSMIC
COSN26565543 54 COSMIC
COSN30459659 58 COSMIC
COSN31542946 78 COSMIC
COSN13910342 88 COSMIC
COSN30160670 115 COSMIC
COSN30126722 139 COSMIC
COSN26573908 148 COSMIC
COSN1083246 164 COSMIC
COSN31515556 164 COSMIC
COSN9164114 214 COSMIC
COSN9164113 278 COSMIC
COSN9164112 711 COSMIC
COSN10029495 1009 COSMIC
COSN1260814 1170 COSMIC
COSN29087490 1250 COSMIC
COSN31519813 1310 COSMIC
COSN5990953 1322 COSMIC
COSN21454287 1337 COSMIC
COSN31524636 1357 COSMIC
COSN31548992 1473 COSMIC
COSN14538909 1506 COSMIC
COSN31543929 1547 COSMIC
COSN5770767 1574 COSMIC
COSN31576459 1633 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1396669910 8 dbSNP
rs1389876760 10 dbSNP
rs369530208 12 dbSNP
rs747923636 14 dbSNP
rs779028236 16 dbSNP
rs756259268 20 dbSNP
rs1205965488 22 dbSNP
rs750449427 27 dbSNP
rs781752629 30 dbSNP
rs1392037919 32 dbSNP
rs1210812471 35 dbSNP
rs757701464 37 dbSNP
rs1397810971 47 dbSNP
rs751986034 51 dbSNP
rs1405357157 56 dbSNP
rs113471863 57 dbSNP
rs1297177122 59 dbSNP
rs1441849944 59 dbSNP
rs1304449200 60 dbSNP
rs557457548 62 dbSNP
rs1392037694 66 dbSNP
rs1362714375 83 dbSNP
rs193136448 88 dbSNP
rs998249595 89 dbSNP
rs1452067951 90 dbSNP
rs79085650 99 dbSNP
rs1025838363 103 dbSNP
rs546844810 109 dbSNP
rs898619268 110 dbSNP
rs1183088604 123 dbSNP
rs1207658746 139 dbSNP
rs1245786277 143 dbSNP
rs1039649579 144 dbSNP
rs1448421940 144 dbSNP
rs936020874 154 dbSNP
rs1038455160 163 dbSNP
rs1472720040 163 dbSNP
rs1266803041 169 dbSNP
rs1420056337 173 dbSNP
rs1201064485 175 dbSNP
rs62238097 176 dbSNP
rs1260941778 179 dbSNP
rs1203328354 181 dbSNP
rs550057514 181 dbSNP
rs1330866103 183 dbSNP
rs530281299 190 dbSNP
rs3177539 193 dbSNP
rs1339657883 195 dbSNP
rs188925071 197 dbSNP
rs1295076079 198 dbSNP
rs1335435671 199 dbSNP
rs1227221301 201 dbSNP
rs1265760256 201 dbSNP
rs1222465560 203 dbSNP
rs1320939194 204 dbSNP
rs1284845319 205 dbSNP
rs1205361725 207 dbSNP
rs1262799843 211 dbSNP
rs1436564905 212 dbSNP
rs1325409207 215 dbSNP
rs370064345 216 dbSNP
rs1158499110 217 dbSNP
rs1362200147 218 dbSNP
rs1455478884 219 dbSNP
rs1381032223 221 dbSNP
rs1391240378 222 dbSNP
rs1159379357 227 dbSNP
rs1401173577 227 dbSNP
rs1160400646 241 dbSNP
rs1394103493 242 dbSNP
rs77177607 243 dbSNP
rs1314545660 249 dbSNP
rs1355997799 251 dbSNP
rs1175277277 253 dbSNP
rs1182098271 253 dbSNP
rs1182752276 253 dbSNP
rs1213588616 253 dbSNP
rs1236129097 253 dbSNP
rs1248438457 253 dbSNP
rs1250160572 253 dbSNP
rs1255080428 253 dbSNP
rs1282989548 253 dbSNP
rs1285837223 253 dbSNP
rs1296402662 253 dbSNP
rs1300058609 253 dbSNP
rs1316625575 253 dbSNP
rs1328988389 253 dbSNP
rs1337029683 253 dbSNP
rs1342485079 253 dbSNP
rs1375840340 253 dbSNP
rs1377261758 253 dbSNP
rs1391430364 253 dbSNP
rs1397957386 253 dbSNP
rs1409207528 253 dbSNP
rs1420981454 253 dbSNP
rs1433156660 253 dbSNP
rs1486284283 253 dbSNP
rs551089600 253 dbSNP
rs60514280 253 dbSNP
rs71202020 253 dbSNP
rs756033353 253 dbSNP
rs1196441168 254 dbSNP
rs1384283622 254 dbSNP
rs1481929973 254 dbSNP
rs9621135 255 dbSNP
rs895150629 260 dbSNP
rs1056455532 262 dbSNP
rs13057380 272 dbSNP
rs1469655733 273 dbSNP
rs1395401928 276 dbSNP
rs1351891425 279 dbSNP
rs1427425271 281 dbSNP
rs1168102869 282 dbSNP
rs1374699221 293 dbSNP
rs140189544 303 dbSNP
rs1478363175 308 dbSNP
rs923841857 309 dbSNP
rs1442580588 312 dbSNP
rs1372581760 318 dbSNP
rs1372133084 319 dbSNP
rs1214319431 320 dbSNP
rs527911332 321 dbSNP
rs1041641213 324 dbSNP
rs1309776974 326 dbSNP
rs1042248309 335 dbSNP
rs1264881296 336 dbSNP
rs1467210877 340 dbSNP
rs1466212766 342 dbSNP
rs565366590 343 dbSNP
rs917127047 345 dbSNP
rs974473412 352 dbSNP
rs1428983070 360 dbSNP
rs992557676 365 dbSNP
rs13058336 366 dbSNP
rs1164014558 370 dbSNP
rs111851903 383 dbSNP
rs531735827 393 dbSNP
rs377348549 404 dbSNP
rs1165064308 418 dbSNP
rs973028484 427 dbSNP
rs1219464709 431 dbSNP
rs562823766 434 dbSNP
rs531734546 437 dbSNP
rs182278776 440 dbSNP
rs1364539284 448 dbSNP
rs955670385 465 dbSNP
rs1293245123 471 dbSNP
rs1333385535 472 dbSNP
rs1367950443 473 dbSNP
rs1235186247 477 dbSNP
rs983095235 478 dbSNP
rs1273949840 484 dbSNP
rs1321856826 488 dbSNP
rs1243576092 491 dbSNP
rs1452369509 492 dbSNP
rs1026312111 496 dbSNP
rs766857327 498 dbSNP
rs1255282059 505 dbSNP
rs1476174827 507 dbSNP
rs1188039962 509 dbSNP
rs1410587436 512 dbSNP
rs1398533544 513 dbSNP
rs1160866351 516 dbSNP
rs1347275434 524 dbSNP
rs753334803 526 dbSNP
rs1336324751 527 dbSNP
rs962878429 528 dbSNP
rs1418827826 529 dbSNP
rs1166207422 533 dbSNP
rs1017074089 535 dbSNP
rs1012355000 536 dbSNP
rs567290442 536 dbSNP
rs1222232398 539 dbSNP
rs1286652474 549 dbSNP
rs1317788597 552 dbSNP
rs146144869 552 dbSNP
rs1277996710 554 dbSNP
rs1486573479 556 dbSNP
rs1003935908 565 dbSNP
rs998321446 566 dbSNP
rs899903500 567 dbSNP
rs1238993548 571 dbSNP
rs1250360453 571 dbSNP
rs1018316335 575 dbSNP
rs540399219 577 dbSNP
rs1000570613 581 dbSNP
rs904554920 584 dbSNP
rs1237174472 589 dbSNP
rs946604273 602 dbSNP
rs761317064 612 dbSNP
rs1432291043 614 dbSNP
rs1042021476 616 dbSNP
rs1173397468 627 dbSNP
rs1374035489 628 dbSNP
rs1437067648 638 dbSNP
rs1314047403 639 dbSNP
rs774076620 669 dbSNP
rs893645220 671 dbSNP
rs1440076923 674 dbSNP
rs946006533 678 dbSNP
rs1038822311 685 dbSNP
rs895637956 690 dbSNP
rs1374313298 695 dbSNP
rs1270512451 700 dbSNP
rs768013593 706 dbSNP
rs1300911815 712 dbSNP
rs943137070 713 dbSNP
rs1056964130 730 dbSNP
rs1272162807 736 dbSNP
rs150036938 744 dbSNP
rs926998847 758 dbSNP
rs1386243600 761 dbSNP
rs866719762 767 dbSNP
rs973184003 770 dbSNP
rs928955319 775 dbSNP
rs941689867 782 dbSNP
rs1455881852 798 dbSNP
rs557420580 801 dbSNP
rs1419401476 808 dbSNP
rs554549974 819 dbSNP
rs866238566 829 dbSNP
rs1355198742 830 dbSNP
rs1327180794 840 dbSNP
rs959467189 841 dbSNP
rs2240176 842 dbSNP
rs1003581662 851 dbSNP
rs1162779300 854 dbSNP
rs568611573 856 dbSNP
rs369158431 857 dbSNP
rs1020916183 858 dbSNP
rs1467659360 864 dbSNP
rs1211395017 884 dbSNP
rs1010799992 893 dbSNP
rs1468682847 896 dbSNP
rs1200010057 897 dbSNP
rs554899583 900 dbSNP
rs964188895 901 dbSNP
rs75171687 910 dbSNP
rs1000323114 919 dbSNP
rs766615108 922 dbSNP
rs1420265788 939 dbSNP
rs2240175 943 dbSNP
rs528658752 952 dbSNP
rs1396940507 956 dbSNP
rs372235361 957 dbSNP
rs895698578 963 dbSNP
rs1324485368 965 dbSNP
rs1432754446 967 dbSNP
rs1270732911 977 dbSNP
rs773550076 980 dbSNP
rs1222331451 982 dbSNP
rs1334121929 986 dbSNP
rs1230902418 997 dbSNP
rs1057081039 998 dbSNP
rs1274570408 999 dbSNP
rs759432521 1004 dbSNP
rs1204191686 1005 dbSNP
rs1001363977 1006 dbSNP
rs1283942107 1009 dbSNP
rs918935201 1014 dbSNP
rs1292690763 1015 dbSNP
rs552628064 1019 dbSNP
rs973063562 1025 dbSNP
rs1264500945 1026 dbSNP
rs1475199221 1027 dbSNP
rs905733864 1028 dbSNP
rs1420115233 1034 dbSNP
rs1373128391 1040 dbSNP
rs910118123 1044 dbSNP
rs1382467381 1045 dbSNP
rs373414682 1049 dbSNP
rs991025609 1052 dbSNP
rs1412931504 1053 dbSNP
rs1294521694 1057 dbSNP
rs1355564678 1058 dbSNP
rs1411906128 1061 dbSNP
rs1258546610 1064 dbSNP
rs17760119 1065 dbSNP
rs543332218 1068 dbSNP
rs139337365 1071 dbSNP
rs1302655905 1072 dbSNP
rs75417079 1073 dbSNP
rs907630837 1076 dbSNP
rs774030115 1077 dbSNP
rs1165481320 1085 dbSNP
rs1209367749 1089 dbSNP
rs966797125 1093 dbSNP
rs747148752 1095 dbSNP
rs1405525315 1102 dbSNP
rs1424508945 1104 dbSNP
rs1047367197 1108 dbSNP
rs1181233904 1108 dbSNP
rs1471314138 1128 dbSNP
rs1472725152 1132 dbSNP
rs1010850994 1133 dbSNP
rs1374632927 1137 dbSNP
rs1432723362 1138 dbSNP
rs1314685697 1139 dbSNP
rs932990196 1142 dbSNP
rs756766035 1146 dbSNP
rs1337154902 1147 dbSNP
rs1239317720 1152 dbSNP
rs1310372576 1162 dbSNP
rs922822722 1163 dbSNP
rs1017464916 1171 dbSNP
rs1489213347 1179 dbSNP
rs1195292732 1180 dbSNP
rs1439708259 1184 dbSNP
rs1179513548 1188 dbSNP
rs1394206931 1196 dbSNP
rs1452305382 1199 dbSNP
rs977005494 1206 dbSNP
rs1007396340 1216 dbSNP
rs1248949511 1221 dbSNP
rs964175877 1222 dbSNP
rs911411683 1223 dbSNP
rs979240129 1235 dbSNP
rs890287023 1236 dbSNP
rs1398023570 1239 dbSNP
rs1446996625 1241 dbSNP
rs778085443 1245 dbSNP
rs1324842701 1249 dbSNP
rs968802279 1251 dbSNP
rs552009026 1257 dbSNP
rs1266661889 1266 dbSNP
rs1230413625 1268 dbSNP
rs531799084 1271 dbSNP
rs1010205943 1281 dbSNP
rs1227348902 1287 dbSNP
rs867482208 1297 dbSNP
rs150861994 1298 dbSNP
rs1035603658 1301 dbSNP
rs879147948 1305 dbSNP
rs1199392438 1325 dbSNP
rs758374336 1335 dbSNP
rs1037395802 1337 dbSNP
rs1282931332 1339 dbSNP
rs1195261436 1342 dbSNP
rs1267791604 1345 dbSNP
rs941674340 1346 dbSNP
rs910171055 1356 dbSNP
rs543015037 1362 dbSNP
rs1055393396 1364 dbSNP
rs372733563 1369 dbSNP
rs1465665320 1377 dbSNP
rs1163648677 1381 dbSNP
rs569832692 1383 dbSNP
rs1429971905 1391 dbSNP
rs982276404 1392 dbSNP
rs1368767145 1394 dbSNP
rs560379252 1395 dbSNP
rs886149659 1402 dbSNP
rs967227704 1404 dbSNP
rs1047941963 1410 dbSNP
rs1219311597 1412 dbSNP
rs913983085 1418 dbSNP
rs932980389 1430 dbSNP
rs1322268345 1437 dbSNP
rs922977599 1440 dbSNP
rs368409296 1447 dbSNP
rs1485437584 1453 dbSNP
rs942981567 1471 dbSNP
rs1184606463 1479 dbSNP
rs1263739123 1483 dbSNP
rs1478142797 1484 dbSNP
rs1186604635 1485 dbSNP
rs1415028938 1487 dbSNP
rs1462640289 1488 dbSNP
rs376750576 1495 dbSNP
rs1017516988 1503 dbSNP
rs1007448829 1504 dbSNP
rs1287544201 1505 dbSNP
rs954620809 1510 dbSNP
rs1401148057 1512 dbSNP
rs540198858 1512 dbSNP
rs1030608092 1513 dbSNP
rs1434338962 1516 dbSNP
rs1230198590 1521 dbSNP
rs1313667271 1528 dbSNP
rs993326692 1531 dbSNP
rs897609420 1539 dbSNP
rs911474636 1541 dbSNP
rs1262344571 1558 dbSNP
rs1488540401 1567 dbSNP
rs1037448472 1580 dbSNP
rs141466699 1599 dbSNP
rs969302071 1600 dbSNP
rs574233691 1601 dbSNP
rs189543295 1604 dbSNP
rs1406772059 1607 dbSNP
rs1055446394 1610 dbSNP
rs1485840854 1611 dbSNP
rs866913031 1617 dbSNP
rs1246780273 1618 dbSNP
rs938276901 1626 dbSNP
rs772171034 1627 dbSNP
rs928227221 1630 dbSNP
rs139063703 1632 dbSNP
rs574956905 1633 dbSNP
rs765839601 1637 dbSNP
rs555073764 1638 dbSNP
rs1222290900 1643 dbSNP
rs1311108015 1643 dbSNP
rs535418949 1644 dbSNP
rs771116751 1646 dbSNP
rs1231356188 1648 dbSNP
rs1354178353 1651 dbSNP
rs1233426096 1654 dbSNP
rs1313982067 1659 dbSNP
rs914035738 1667 dbSNP
rs1387206810 1668 dbSNP
rs1210199825 1671 dbSNP
rs1231817919 1673 dbSNP
rs1479420598 1674 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL35
Disease MIMAT0018098
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020022. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuuagagaugUCUUCGGGGUau 5'
                     ||: |||: |  
Target 5' --------ucaAGGUGCCUGAag 3'
 		1 - 15
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020022
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL35 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000397641.3 | 3UTR | UCAAGGUGCCUGAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
32 hsa-miR-3675-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT366903 NONO non-POU domain containing octamer binding 2 2
MIRT453894 DUSP18 dual specificity phosphatase 18 2 2
MIRT461725 ZNF426 zinc finger protein 426 2 2
MIRT464694 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465957 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466038 TMEM189 transmembrane protein 189 2 2
MIRT471546 PAX5 paired box 5 2 2
MIRT472813 MTMR12 myotubularin related protein 12 2 2
MIRT474099 LMBR1L limb development membrane protein 1 like 2 2
MIRT480205 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2 2
MIRT488268 HSP90AB1 heat shock protein 90 alpha family class B member 1 2 8
MIRT491222 MRPL34 mitochondrial ribosomal protein L34 2 2
MIRT494768 AP1G1 adaptor related protein complex 1 gamma 1 subunit 2 2
MIRT497228 MORC2 MORC family CW-type zinc finger 2 2 2
MIRT501676 PFN1 profilin 1 2 6
MIRT511831 H2AFX H2A histone family member X 2 4
MIRT513880 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT519402 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT522627 MAP7D1 MAP7 domain containing 1 2 4
MIRT546998 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT555119 PUM2 pumilio RNA binding family member 2 2 2
MIRT560380 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT572188 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT634822 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT641149 DNMBP dynamin binding protein 2 2
MIRT647389 ZNF616 zinc finger protein 616 2 2
MIRT670851 SFT2D2 SFT2 domain containing 2 2 2
MIRT698600 TEX261 testis expressed 261 2 2
MIRT698691 TBPL1 TATA-box binding protein like 1 2 2
MIRT708725 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT718340 SYNDIG1L synapse differentiation inducing 1 like 2 2
MIRT725514 FBXO46 F-box protein 46 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3675 Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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