miRTarBase - #MIRT497297


—
pre-miRNA Information
pre-miRNA hsa-mir-500b   
Genomic Coordinates chrX: 50010672 - 50010750
Description Homo sapiens miR-500b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-500b-3p
Sequence 51| GCACCCAGGCAAGGAUUCUG |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs782140253 8 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMEM119   
Synonyms OBIF
Description transmembrane protein 119
Transcript NM_181724   
Expression
Putative miRNA Targets on TMEM119
3'UTR of TMEM119
(miRNA target sites are highlighted)		 
>TMEM119|NM_181724|3'UTR
   1 CAGTCCTCCCGGGCTGCCAGCCCTGACTGTCGGGCCCCCAAGTGGTCACCTCCCCGTGTATGAAAAGGCCTTCAGCCCTG
  81 ACTGCTTCCTGACACTCCCTCCTTGGCCTCCCTGTGGTGCCAATCCCAGCATGTGCTGATTCTACAGCAGGCAGAAATGC
 161 TGGTCCCCGGTGCCCCGGAGGAATCTTACCAAGTGCCATCATCCTTCACCTCAGCAGCCCCAAAGGGCTACATCCTACAG
 241 CACAGCTCCCCTGACAAAGTGAGGGAGGGCACGTGTCCCTGTGACAGCCAGGATAAAACATCCCTCAAGGCTGGGTGTGG
 321 AGGCTCACACCTGTAATCTCAGCATTTTGGGAGGCCAAGTGCGGACATCACTTGAGACCAGGAGTTCCAAACCAGCCCTG
 401 GCAACATTGTGAGACCCATCTCTATAAAAACAAAAAACAGTCCACTAAATCAGCCACATTAATTGGGAATCATATGTCAC
 481 AGGTCATTTGTGGGGCAAACATCACTGCTTTTCCATCAAGGGAGCAAAGAATAAGTGGGAGTTTTGGAAGAGTTTGGATG
 561 AGAGACGCCAAGGTGCCCAGCGTTCGTAAGGCAACATGCAGCCTGGCGTGAAGCAGTATTTTGAAACTGCAAATGGTTCC
 641 CTTCTTGTGTCCTTTCAATGCTGAATATTTTAGTGTCATTCTGCCTGTGCTCAGAGCTCCAGCAGCAGAAGTGTGTGTGG
 721 TTAATTAGGACACTTCTGTGAGAGGACCCCTGCACACATTACGACAGGTCCCTAAATGAGCATTTCCCAAACTAGGTTCC
 801 CCGAGGCACTCTACGGAAACAAGATTTTTTTTTTTGAGACGGAGTCTCGGTCTGTCACCCAGGCTGGAGTGCAGTGGTGC
 881 AATCTTGGTGCAATCTTGGCTCAGTGCAATCCGCCTCCCAGGTTCAAGCGATTCTCCCGCCTCAGTAGCTGGGATTACAG
 961 GTGCCCACCACTGCGCCCAGCTAAATTTTGTATTTTTAGTAGAGATGGGGCTTCACCATGTTGGCCAGGCTGGTCTGGAA
1041 CTCCTGACCTTCAGGTGATCCACCTGCCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCCA
1121 AACTACTTTTTAAAACAGCTACAGGGTAAAATCCTGCAGCACCCACTCTGGAAAATACTGCTCTTAATTTTCCTGAAGGT
1201 GGCCCCCTGTTTCTAGTTGGTCCAGGATTAGGGATGTGGGGTATAGGGCATTTAAATCCTCTCAAGCGCTCTCCAAGCAC
1281 CCCCGGCCTGGGGGTGAGTTTCTCATCCCGCTACTGCTGCTGGGATCAGGTTGAATGAATGGAACTCTTCCTGTCTGGCC
1361 TCCAAAGCAGCCTAGAAGCTGAGGGGCTGTGTTTGAGGGGACCTCCACCCTGGGGAAGTCCGAGGGGCTGGGGAAGGGTT
1441 TCTGACGCCCAGCCTGGAGCAGGGGGGCCCTGGCCACCCCCTGTTGCTCACACATTGTCTGGCAGCCTGTGTCCACAATA
1521 TTCGTCAGTCCTCGACAGGGAGCCTGGGCTCCGTCCTGCTTTAGGGAGGCTCTGGCAGGAGGTCCTCTCCCCCATCCCTC
1601 CATCTGGGGCTCCCCCAACCTCTGCACAGCTCTCCAGGTGCTGAGATATAATGCACCAGCACAATAAACCTTTATTCCGG
1681 CCTGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gucuUAGGAA---CGGACCCACg 5'
              |||| |   | ||||||| 
Target 5' aaacATCCCTCAAGGCTGGGTGt 3'
 296 - 318 152.00 -16.00
2 
miRNA  3' gucuuAGGAAC-----GGAC-CCACg 5'
               ||||||     |||| |||| 
Target 5' ctcccTCCTTGGCCTCCCTGTGGTGc 3'
 95 - 120 127.00 -19.60
3 
miRNA  3' gucuuaGGAACGGACCCACg 5'
                ||  ||||||| | 
Target 5' agcaccCCCGGCCTGGGGGt 3'
 1276 - 1295 122.00 -17.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28841067 24 COSMIC
COSN13365825 32 COSMIC
COSN7309500 32 COSMIC
COSN2529131 35 COSMIC
COSN30450428 62 COSMIC
COSN26998837 74 COSMIC
COSN30187089 75 COSMIC
COSN30460222 77 COSMIC
COSN30508186 83 COSMIC
COSN30448990 89 COSMIC
COSN30460214 101 COSMIC
COSN30191279 106 COSMIC
COSN28827137 109 COSMIC
COSN16102128 189 COSMIC
COSN5929813 287 COSMIC
COSN8288468 582 COSMIC
COSN5929812 586 COSMIC
COSN16656265 699 COSMIC
COSN32056327 802 COSMIC
COSN21643041 840 COSMIC
COSN19118682 1062 COSMIC
COSN5929811 1104 COSMIC
COSN18829764 1142 COSMIC
COSN10097290 1239 COSMIC
COSN8288467 1310 COSMIC
COSN17960274 1315 COSMIC
COSN4700684 1406 COSMIC
COSN29691548 1461 COSMIC
COSN26806305 1579 COSMIC
COSN7309499 1605 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757398617 1 dbSNP
rs1380953463 2 dbSNP
rs1300555307 5 dbSNP
rs754041509 8 dbSNP
rs1401575233 9 dbSNP
rs372239092 10 dbSNP
rs202053237 11 dbSNP
rs751508493 21 dbSNP
rs1188724556 23 dbSNP
rs780813342 25 dbSNP
rs1254401455 26 dbSNP
rs532487337 28 dbSNP
rs906286847 31 dbSNP
rs762587238 32 dbSNP
rs377187768 33 dbSNP
rs1314640506 35 dbSNP
rs764758707 36 dbSNP
rs1237638081 37 dbSNP
rs1250529062 38 dbSNP
rs1245321288 39 dbSNP
rs1256234339 40 dbSNP
rs371790803 41 dbSNP
rs1310141402 43 dbSNP
rs947947401 44 dbSNP
rs916498875 55 dbSNP
rs866258538 56 dbSNP
rs940585822 56 dbSNP
rs543021765 57 dbSNP
rs1417406516 58 dbSNP
rs1158470564 61 dbSNP
rs1378485001 68 dbSNP
rs1436788856 75 dbSNP
rs1475071264 92 dbSNP
rs2287557 109 dbSNP
rs1374657594 112 dbSNP
rs1430110474 114 dbSNP
rs1196458812 115 dbSNP
rs560669050 119 dbSNP
rs937159296 123 dbSNP
rs1478551943 124 dbSNP
rs927134913 125 dbSNP
rs1301345112 131 dbSNP
rs112422811 152 dbSNP
rs77620385 157 dbSNP
rs553572212 159 dbSNP
rs962404016 160 dbSNP
rs988813800 162 dbSNP
rs1451857023 163 dbSNP
rs1253661930 165 dbSNP
rs957370602 168 dbSNP
rs1176735008 169 dbSNP
rs912012779 176 dbSNP
rs988040198 177 dbSNP
rs1192008514 189 dbSNP
rs748467711 192 dbSNP
rs1258707233 198 dbSNP
rs1029185534 202 dbSNP
rs1172265898 204 dbSNP
rs1352751132 207 dbSNP
rs1461404931 221 dbSNP
rs1293652104 227 dbSNP
rs1396076405 230 dbSNP
rs1220407458 232 dbSNP
rs1011086568 248 dbSNP
rs779426023 259 dbSNP
rs1438021056 260 dbSNP
rs1302239562 263 dbSNP
rs1338248159 266 dbSNP
rs958301892 269 dbSNP
rs373206024 272 dbSNP
rs147638664 273 dbSNP
rs1306307962 277 dbSNP
rs745495676 278 dbSNP
rs1321790560 280 dbSNP
rs1274298431 284 dbSNP
rs1461307912 295 dbSNP
rs1469887573 306 dbSNP
rs1211827241 307 dbSNP
rs559261723 308 dbSNP
rs1046186272 316 dbSNP
rs1012070550 317 dbSNP
rs895010006 322 dbSNP
rs1014682529 341 dbSNP
rs1401460560 349 dbSNP
rs1475857156 357 dbSNP
rs78430140 361 dbSNP
rs931177729 362 dbSNP
rs918519016 363 dbSNP
rs199637284 365 dbSNP
rs887453408 366 dbSNP
rs1048982762 368 dbSNP
rs1324614923 369 dbSNP
rs1388981000 382 dbSNP
rs1036764150 394 dbSNP
rs1432416013 405 dbSNP
rs1478057578 406 dbSNP
rs576533894 412 dbSNP
rs74930907 420 dbSNP
rs1294452808 425 dbSNP
rs1337580062 426 dbSNP
rs1231593097 431 dbSNP
rs756694231 438 dbSNP
rs1046011811 440 dbSNP
rs761742790 441 dbSNP
rs950163350 449 dbSNP
rs1218255487 450 dbSNP
rs913281065 456 dbSNP
rs987600240 457 dbSNP
rs1188383571 462 dbSNP
rs117752186 480 dbSNP
rs566040729 483 dbSNP
rs1163626583 496 dbSNP
rs935974924 517 dbSNP
rs925974483 519 dbSNP
rs985716393 532 dbSNP
rs189680738 536 dbSNP
rs1344167798 538 dbSNP
rs74788233 539 dbSNP
rs7303227 557 dbSNP
rs543231136 563 dbSNP
rs1413442120 564 dbSNP
rs549634727 566 dbSNP
rs1273351895 567 dbSNP
rs1282431363 573 dbSNP
rs538838778 577 dbSNP
rs970444412 581 dbSNP
rs758332390 582 dbSNP
rs1333830563 585 dbSNP
rs1444968516 586 dbSNP
rs977285711 588 dbSNP
rs1177387552 592 dbSNP
rs748739215 596 dbSNP
rs1011978885 597 dbSNP
rs1426649162 599 dbSNP
rs961543765 606 dbSNP
rs7303338 607 dbSNP
rs1453453340 608 dbSNP
rs1174702896 609 dbSNP
rs1380477533 613 dbSNP
rs560581461 616 dbSNP
rs1377688350 623 dbSNP
rs1433198339 628 dbSNP
rs1334103171 634 dbSNP
rs1336803376 642 dbSNP
rs1180328786 651 dbSNP
rs776742778 651 dbSNP
rs553047352 655 dbSNP
rs1004650843 657 dbSNP
rs1026785159 660 dbSNP
rs995373824 663 dbSNP
rs897059170 672 dbSNP
rs185462648 674 dbSNP
rs940672632 681 dbSNP
rs11291691 686 dbSNP
rs1278294634 711 dbSNP
rs764925208 712 dbSNP
rs1233613466 719 dbSNP
rs1201888636 720 dbSNP
rs759422004 730 dbSNP
rs905816364 732 dbSNP
rs567429244 740 dbSNP
rs1392819934 747 dbSNP
rs1452970440 749 dbSNP
rs922030648 750 dbSNP
rs1172359181 759 dbSNP
rs559944087 762 dbSNP
rs936894154 763 dbSNP
rs1303993249 767 dbSNP
rs541621690 780 dbSNP
rs1450833870 790 dbSNP
rs924170677 796 dbSNP
rs978397394 799 dbSNP
rs182660870 801 dbSNP
rs7303034 802 dbSNP
rs1160077801 803 dbSNP
rs1270530760 811 dbSNP
rs544161932 814 dbSNP
rs1417138621 815 dbSNP
rs191571239 823 dbSNP
rs186441671 829 dbSNP
rs1468552197 834 dbSNP
rs922810391 836 dbSNP
rs932670528 836 dbSNP
rs536209076 840 dbSNP
rs1026775261 841 dbSNP
rs1182167670 845 dbSNP
rs745540208 848 dbSNP
rs572514001 849 dbSNP
rs1210326071 858 dbSNP
rs146931938 859 dbSNP
rs1392617073 874 dbSNP
rs538847363 876 dbSNP
rs951811887 880 dbSNP
rs1213891566 882 dbSNP
rs1008120806 893 dbSNP
rs1316499517 900 dbSNP
rs1313922430 901 dbSNP
rs1270693668 902 dbSNP
rs1333473022 903 dbSNP
rs1205374295 904 dbSNP
rs1263325885 905 dbSNP
rs1027320906 912 dbSNP
rs1449101268 912 dbSNP
rs374167547 913 dbSNP
rs1475807310 914 dbSNP
rs559342915 917 dbSNP
rs1413704252 919 dbSNP
rs1457429868 921 dbSNP
rs1360586210 929 dbSNP
rs1051684045 930 dbSNP
rs1416575191 936 dbSNP
rs148813244 938 dbSNP
rs900592262 939 dbSNP
rs1053823568 941 dbSNP
rs1262193886 944 dbSNP
rs1348081860 945 dbSNP
rs1165251270 971 dbSNP
rs936822977 975 dbSNP
rs1285720033 976 dbSNP
rs1000234390 980 dbSNP
rs1486181533 980 dbSNP
rs1415638839 987 dbSNP
rs371669711 989 dbSNP
rs760787663 999 dbSNP
rs1187134095 1010 dbSNP
rs369423271 1015 dbSNP
rs1158230068 1026 dbSNP
rs1478223893 1028 dbSNP
rs1265446103 1031 dbSNP
rs1436285857 1032 dbSNP
rs1184790563 1033 dbSNP
rs1485677054 1035 dbSNP
rs1266235753 1040 dbSNP
rs773438738 1043 dbSNP
rs1391522461 1045 dbSNP
rs1308490350 1055 dbSNP
rs1274610601 1062 dbSNP
rs1049844248 1066 dbSNP
rs978667409 1067 dbSNP
rs549546694 1068 dbSNP
rs1349065765 1070 dbSNP
rs949627593 1074 dbSNP
rs932614382 1076 dbSNP
rs1254833196 1084 dbSNP
rs922645436 1094 dbSNP
rs918206912 1095 dbSNP
rs537788132 1098 dbSNP
rs537475937 1099 dbSNP
rs1219796138 1101 dbSNP
rs908705422 1102 dbSNP
rs1395846296 1103 dbSNP
rs772640840 1105 dbSNP
rs1171507812 1108 dbSNP
rs1026719749 1109 dbSNP
rs377073207 1114 dbSNP
rs1299775293 1115 dbSNP
rs1393719812 1119 dbSNP
rs1445328693 1136 dbSNP
rs973787440 1138 dbSNP
rs1293725343 1142 dbSNP
rs548570435 1144 dbSNP
rs1237040742 1145 dbSNP
rs1299619671 1148 dbSNP
rs961435868 1153 dbSNP
rs1228817141 1161 dbSNP
rs952861302 1165 dbSNP
rs920306919 1169 dbSNP
rs1198080284 1179 dbSNP
rs762405044 1181 dbSNP
rs1253929305 1182 dbSNP
rs1391997542 1183 dbSNP
rs979890023 1194 dbSNP
rs970105291 1199 dbSNP
rs1172463308 1209 dbSNP
rs1015389304 1213 dbSNP
rs1023998081 1231 dbSNP
rs868602709 1233 dbSNP
rs1325982472 1238 dbSNP
rs367584754 1240 dbSNP
rs955311725 1241 dbSNP
rs1396293377 1242 dbSNP
rs527251100 1246 dbSNP
rs771975428 1249 dbSNP
rs1031552494 1256 dbSNP
rs1028238336 1257 dbSNP
rs1367359253 1258 dbSNP
rs999949987 1260 dbSNP
rs1383061443 1263 dbSNP
rs774982938 1268 dbSNP
rs996115550 1269 dbSNP
rs904368568 1273 dbSNP
rs768882196 1276 dbSNP
rs1028802128 1277 dbSNP
rs145521666 1281 dbSNP
rs1168484953 1283 dbSNP
rs181705477 1284 dbSNP
rs1268401142 1285 dbSNP
rs1188044612 1290 dbSNP
rs1261017240 1294 dbSNP
rs533031161 1297 dbSNP
rs1467261845 1306 dbSNP
rs902604010 1309 dbSNP
rs1042552798 1310 dbSNP
rs565520108 1313 dbSNP
rs1345412211 1315 dbSNP
rs1454682604 1319 dbSNP
rs749705467 1321 dbSNP
rs1051924 1331 dbSNP
rs887319998 1337 dbSNP
rs576814335 1339 dbSNP
rs386766252 1340 dbSNP
rs55939119 1342 dbSNP
rs1301614736 1351 dbSNP
rs868861614 1353 dbSNP
rs1289519213 1370 dbSNP
rs1317733670 1377 dbSNP
rs372838106 1385 dbSNP
rs543026139 1386 dbSNP
rs974147244 1387 dbSNP
rs572319931 1391 dbSNP
rs1325011467 1397 dbSNP
rs961121647 1401 dbSNP
rs551688462 1408 dbSNP
rs554113004 1421 dbSNP
rs1398594495 1422 dbSNP
rs746445567 1424 dbSNP
rs992413199 1426 dbSNP
rs1402051760 1431 dbSNP
rs866692476 1438 dbSNP
rs545202850 1444 dbSNP
rs528268454 1446 dbSNP
rs542526735 1447 dbSNP
rs996691254 1448 dbSNP
rs537602572 1451 dbSNP
rs796448889 1452 dbSNP
rs968935833 1465 dbSNP
rs1032268771 1467 dbSNP
rs1374385954 1468 dbSNP
rs1459349303 1472 dbSNP
rs1001307188 1480 dbSNP
rs757958419 1481 dbSNP
rs1307293581 1483 dbSNP
rs1042888867 1487 dbSNP
rs1013738806 1492 dbSNP
rs1282455642 1493 dbSNP
rs1440603085 1505 dbSNP
rs1256081591 1523 dbSNP
rs1004184908 1524 dbSNP
rs1232983529 1525 dbSNP
rs1470851757 1533 dbSNP
rs896625717 1540 dbSNP
rs1302196687 1552 dbSNP
rs1427929528 1553 dbSNP
rs931605252 1557 dbSNP
rs1055317727 1564 dbSNP
rs1051994 1572 dbSNP
rs1240687740 1574 dbSNP
rs1355212387 1577 dbSNP
rs1337294962 1578 dbSNP
rs1449000022 1582 dbSNP
rs1329632757 1583 dbSNP
rs1304521974 1585 dbSNP
rs1234810974 1593 dbSNP
rs1342561351 1596 dbSNP
rs11718 1602 dbSNP
rs3209586 1604 dbSNP
rs555337588 1608 dbSNP
rs916970011 1609 dbSNP
rs1237253825 1612 dbSNP
rs939723692 1613 dbSNP
rs908270471 1615 dbSNP
rs934304730 1620 dbSNP
rs924301893 1621 dbSNP
rs986983824 1627 dbSNP
rs7298881 1632 dbSNP
rs566378754 1633 dbSNP
rs748560760 1637 dbSNP
rs1467297280 1638 dbSNP
rs921073846 1643 dbSNP
rs1375114790 1675 dbSNP
rs1168591041 1677 dbSNP
rs975220780 1678 dbSNP
rs1441955953 1679 dbSNP
rs957276737 1680 dbSNP
rs1329147236 1681 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL35
Disease MIMAT0027032
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020022. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucuuaggaaCGGACCCACg 5'
                    | ||||||| 
Target 5' ------ucaaGGCUGGGUGu 3'
 		1 - 14
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020022
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL35 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000392806.3 | 3UTR | UCAAGGCUGGGUGUGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
172 hsa-miR-500b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059905 HDGF heparin binding growth factor 2 4
MIRT235394 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 4
MIRT442246 PYGO1 pygopus family PHD finger 1 2 2
MIRT443591 ZNF439 zinc finger protein 439 2 4
MIRT453280 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT463540 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT465589 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT469462 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT485449 KCTD15 potassium channel tetramerization domain containing 15 2 4
MIRT486682 WDR81 WD repeat domain 81 2 2
MIRT489078 POLM DNA polymerase mu 2 2
MIRT493734 GREM2 gremlin 2, DAN family BMP antagonist 2 2
MIRT494872 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT496130 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT496489 CHMP3 charged multivesicular body protein 3 2 2
MIRT496924 CLMN calmin 2 2
MIRT497297 TMEM119 transmembrane protein 119 2 2
MIRT499103 AGRN agrin 2 2
MIRT508979 CXorf38 chromosome X open reading frame 38 2 2
MIRT509911 NIPAL1 NIPA like domain containing 1 2 2
MIRT512820 ARRDC2 arrestin domain containing 2 2 4
MIRT512827 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT515360 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT516610 TRIM58 tripartite motif containing 58 2 2
MIRT517053 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT517637 ZNF491 zinc finger protein 491 2 2
MIRT518270 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT518625 STAR steroidogenic acute regulatory protein 2 2
MIRT518887 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT519026 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT520365 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT521106 SLC1A5 solute carrier family 1 member 5 2 2
MIRT521943 PHC3 polyhomeotic homolog 3 2 2
MIRT522253 NPEPPS aminopeptidase puromycin sensitive 2 2
MIRT522853 KIAA1551 KIAA1551 2 2
MIRT522868 KIAA1549 KIAA1549 2 2
MIRT524207 DDX19B DEAD-box helicase 19B 2 2
MIRT526004 ARHGAP27 Rho GTPase activating protein 27 2 2
MIRT527769 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT527827 TMEM74B transmembrane protein 74B 2 2
MIRT527861 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT528040 WT1 Wilms tumor 1 2 2
MIRT529802 ZDHHC8 zinc finger DHHC-type containing 8 2 2
MIRT531723 TARS threonyl-tRNA synthetase 2 2
MIRT531996 BARD1 BRCA1 associated RING domain 1 2 2
MIRT533338 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533621 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT533652 TMOD2 tropomodulin 2 2 2
MIRT534397 SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2 2
MIRT538686 CCDC80 coiled-coil domain containing 80 2 2
MIRT540444 RBM43 RNA binding motif protein 43 2 2
MIRT542586 ZC3H12C zinc finger CCCH-type containing 12C 2 8
MIRT542796 PLEKHA3 pleckstrin homology domain containing A3 2 4
MIRT542991 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT544424 ZNF460 zinc finger protein 460 2 4
MIRT545740 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 4
MIRT552618 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT554456 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT569663 PRIM1 DNA primase subunit 1 2 2
MIRT569924 PCSK9 proprotein convertase subtilisin/kexin type 9 2 2
MIRT570140 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT573558 TMEM120B transmembrane protein 120B 2 2
MIRT574282 OPRD1 opioid receptor delta 1 2 2
MIRT575335 Fbxo6 F-box protein 6 2 2
MIRT607057 IDS iduronate 2-sulfatase 2 2
MIRT607078 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607500 HEBP2 heme binding protein 2 2 2
MIRT607530 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607808 RHBDL2 rhomboid like 2 2 2
MIRT608079 ZFP14 ZFP14 zinc finger protein 2 2
MIRT609119 NUDT3 nudix hydrolase 3 2 2
MIRT609745 PTCH1 patched 1 2 2
MIRT612904 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 2
MIRT618720 PCSK2 proprotein convertase subtilisin/kexin type 2 2 2
MIRT618778 HLA-E major histocompatibility complex, class I, E 2 2
MIRT619015 SLC2A6 solute carrier family 2 member 6 2 2
MIRT623223 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT623819 GEMIN6 gem nuclear organelle associated protein 6 2 2
MIRT625704 OPTN optineurin 2 2
MIRT626437 CHDH choline dehydrogenase 2 2
MIRT628087 KAT7 lysine acetyltransferase 7 2 2
MIRT628936 APOB apolipoprotein B 2 2
MIRT633543 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634348 SGOL1 shugoshin 1 2 2
MIRT634611 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635243 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT636681 BTLA B and T lymphocyte associated 2 2
MIRT636923 ZNF845 zinc finger protein 845 2 2
MIRT637606 ZNF554 zinc finger protein 554 2 2
MIRT639242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT640835 POLR3A RNA polymerase III subunit A 2 2
MIRT642098 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT643087 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643934 C17orf104 meiosis specific with coiled-coil domain 2 2
MIRT644353 FXN frataxin 2 2
MIRT645628 SF3A3 splicing factor 3a subunit 3 2 2
MIRT645754 FAM213A family with sequence similarity 213 member A 2 2
MIRT646329 MVB12B multivesicular body subunit 12B 2 2
MIRT646817 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647019 ADCY2 adenylate cyclase 2 2 2
MIRT647621 IGSF9B immunoglobulin superfamily member 9B 2 2
MIRT648517 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648871 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649620 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650062 CCDC134 coiled-coil domain containing 134 2 2
MIRT650734 TNFSF8 TNF superfamily member 8 2 2
MIRT652389 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT654352 RBM27 RNA binding motif protein 27 2 2
MIRT655796 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT657329 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT657734 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT660613 ANO6 anoctamin 6 2 2
MIRT661243 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT662245 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662921 MED18 mediator complex subunit 18 2 2
MIRT662963 JPH2 junctophilin 2 2 2
MIRT663347 ZNF74 zinc finger protein 74 2 2
MIRT663528 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663547 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663977 ZNF786 zinc finger protein 786 2 2
MIRT664084 METTL2B methyltransferase like 2B 2 2
MIRT664358 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664421 TIGD6 tigger transposable element derived 6 2 2
MIRT664476 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664979 TDRD1 tudor domain containing 1 2 2
MIRT665128 PYCRL pyrroline-5-carboxylate reductase 3 2 2
MIRT666259 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666321 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666881 POLQ DNA polymerase theta 2 2
MIRT668469 FADS6 fatty acid desaturase 6 2 2
MIRT669554 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669835 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT670185 CCDC142 coiled-coil domain containing 142 2 2
MIRT672020 PXMP4 peroxisomal membrane protein 4 2 2
MIRT672070 KIAA0930 KIAA0930 2 2
MIRT672475 RTTN rotatin 2 2
MIRT672851 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT673090 AK1 adenylate kinase 1 2 2
MIRT673581 KDELC2 KDEL motif containing 2 2 2
MIRT674586 SLC35B4 solute carrier family 35 member B4 2 2
MIRT675001 STRN3 striatin 3 2 2
MIRT679018 MTMR10 myotubularin related protein 10 2 2
MIRT679680 STAT3 signal transducer and activator of transcription 3 2 2
MIRT682833 FLG2 filaggrin family member 2 2 2
MIRT682886 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT683442 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 2
MIRT687040 RNF115 ring finger protein 115 2 2
MIRT691957 RHOH ras homolog family member H 2 2
MIRT694625 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695637 SLC26A2 solute carrier family 26 member 2 2 2
MIRT697640 WRN Werner syndrome RecQ like helicase 2 2
MIRT702009 MIDN midnolin 2 2
MIRT702034 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT704789 CDK6 cyclin dependent kinase 6 2 2
MIRT705728 AMMECR1L AMMECR1 like 2 2
MIRT705879 ADM adrenomedullin 2 2
MIRT706220 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT708418 CERS4 ceramide synthase 4 2 2
MIRT709114 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709595 ITPA inosine triphosphatase 2 2
MIRT710945 MRPL45 mitochondrial ribosomal protein L45 2 2
MIRT712345 NLN neurolysin 2 2
MIRT712530 CYTH2 cytohesin 2 2 2
MIRT714019 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT717287 ARMC12 armadillo repeat containing 12 2 2
MIRT717733 FGF1 fibroblast growth factor 1 2 2
MIRT718083 CLIC5 chloride intracellular channel 5 2 2
MIRT718562 MUC20 mucin 20, cell surface associated 2 2
MIRT721639 MYLK3 myosin light chain kinase 3 2 2
MIRT722632 C8A complement C8 alpha chain 2 2
MIRT723177 CDCA4 cell division cycle associated 4 2 2
MIRT725523 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-500b Methotrexate 126941 NSC740 approved resistant cell line (W1)
hsa-miR-500b-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-500b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-500b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-500b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-500b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-500b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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