miRTarBase - #MIRT497703


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pre-miRNA Information
pre-miRNA hsa-mir-664a   
Genomic Coordinates chr1: 220200538 - 220200619
Description Homo sapiens miR-664 stem-loop
Comment This miRNA sequence overlaps an annotated snoRNA, ACA38b. However, both miR and miR* sequences are identified in reference , and the sequence is homologous with rat mir-664.
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-664a-3p
Sequence 49| UAUUCAUUUAUCCCCAGCCUACA |71
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30457627 12 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1478242335 2 dbSNP
rs1042905485 5 dbSNP
rs908858734 6 dbSNP
rs1229753248 8 dbSNP
rs770101636 12 dbSNP
rs746047168 14 dbSNP
rs1170225715 15 dbSNP
rs1404740911 16 dbSNP
rs1393962832 17 dbSNP
rs1377901643 18 dbSNP
rs1313271494 19 dbSNP
rs1416447585 20 dbSNP
rs1368463251 21 dbSNP
rs1167925254 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARL6IP6   
Synonyms AIP-6, AIP6, PFAAP1
Description ADP ribosylation factor like GTPase 6 interacting protein 6
Transcript NM_152522   
Expression
Putative miRNA Targets on ARL6IP6
3'UTR of ARL6IP6
(miRNA target sites are highlighted)		 
>ARL6IP6|NM_152522|3'UTR
   1 ACCCACACTGGAGCGATATTGTTGGCAAAACTTAATCATGATTGTTTTGTAATAACAAGAAGGAGCATCACTGTCTACTC
  81 AGAAGACTGAGAAACCTGCTGTTCATTATGTAGTTCAGATATTTATCACAATCATCCTCATTATGGAAGACCTTTTAAAG
 161 CATTGTTTTAGAATGTCTGAGTATTAAGATACAGATTAATTGGGAATATCTGAGTATTAAGTACTTTCTTCAGAGTATAA
 241 GATGTTTACCTCATCTTTTTACTTTTGTGTGTGTAGTTCTTTCAAGTTGTAGGAAACATTTTAATGGAATTTAAACTCAA
 321 AAACTTGAATACAGGACAATGCTTGCCTTTTCATGTATGTACTACATTTTTTGCTAAGAAATACTGATATTTCTGTTTAG
 401 TTGAGCTAGAAATACTTCTTATTTATACATTTAGGAAAGCAAATAATGCCTACTACTCCGACTTTTATAGAAGCTACTTT
 481 TAAATCAGAATATTTAATTTTTGATATTCATATAATTAATAGAAGTTGCATTTATATTTTTTATGGGGCATAGTTCCTTA
 561 TGTGTTTTTTTAATGTATTTTCATACTACATACTGAATTTGTATGTTTTTAAAATTGTTACATCTAGACAACTGTAAACA
 641 TTATTTTTTTAGCTAGTGCAAACCTAGTACCTGCCATTTTTACTAATTTTTGTCTTTAAAAAAAGCAAAAAAGCACATTG
 721 ACCTAAGTTGAAAATTAAGTAAGTTTATTTTTAACAAAAAATGCCTGAAAAAAGCTAAATTATTTAAGTCATTAAGATAT
 801 TGAGAAAAAATTTGAAATTTTTACTATTTCTGTTTCCACAATTCCAAATATTTATCTTGGTGTATATATTGTTACTTTAA
 881 CAGAACTTGCATTATTTTGTTTTTAATAAATATAAACATGAAATTTTTGTATGTGAGAATGATTGAACTAGTTTGTTCTT
 961 AATCTCAAAAATTTAGTTACCAAAGTAGAAAAGGTATTTTGATACTAGATATTAAAAACTACATATAGTTAATATAATTT
1041 TATAATTTTTGTAATTAAATGTGCTCCTGTAATTGTGATATTTTGTTTTCTAAGTAATTAAGCCTTAATTTTTCCCCTAT
1121 GTTACTAAAGACTTTTAATGTTTAGAAAGTTACCTCAGTTTTAGAAAGATGGACTACTTACAAAGCTGTTTTCCCTGGCC
1201 ATAGGAAAACTTACAATAAGAAACCATTAAGTAGTCAAACTGCTTATTCAGGCTAAGTGGGAAATGAATTTGTGCAGTGT
1281 GTTCCCTTAATTATCTACTGAATGTTGTTACCGACTAAACAAGGTTTCTAAAAGTCTCGCATTTCTTTTACTATTCAAAA
1361 CTCTTTGGTTGGAAATGACTAATACTGCTCCAATTTAAATTATCTGAAATGTGAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acaUCCGA--CCCCUAUUUACUUAu 5'
             |||||  | ||: |||||||| 
Target 5' ttcAGGCTAAGTGGG-AAATGAATt 3'
 1247 - 1270 165.00 -15.30
2 
miRNA  3' acAUCCGACCCCUAUUUACUUAu 5'
            | ||:|||    |||||| | 
Target 5' ctTTGGTTGG----AAATGACTa 3'
 1363 - 1381 127.00 -9.70
3 
miRNA  3' acaUCCGAC--CCCU-----AUUUA-CUUAu 5'
             | |:||  || |     | ||| |||| 
Target 5' ttcAAGTTGTAGGAAACATTTTAATGGAATt 3'
 281 - 311 114.00 -9.57
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30450100 5 COSMIC
COSN30149213 9 COSMIC
COSN30104661 16 COSMIC
COSN24299076 40 COSMIC
COSN1082661 42 COSMIC
COSN31502199 78 COSMIC
COSN30143989 109 COSMIC
COSN2382258 134 COSMIC
COSN1082660 158 COSMIC
COSN31532706 189 COSMIC
COSN19102740 250 COSMIC
COSN31579209 373 COSMIC
COSN17339824 498 COSMIC
COSN20942515 596 COSMIC
COSN32062511 1079 COSMIC
COSN9228543 1193 COSMIC
COSN21243276 1207 COSMIC
COSN16303665 1361 COSMIC
COSN27483530 1428 COSMIC
COSN20097263 1429 COSMIC
rs3175 2420 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747930229 3 dbSNP
rs769535236 6 dbSNP
rs772868616 7 dbSNP
rs748877617 13 dbSNP
rs1011799336 15 dbSNP
rs559707304 16 dbSNP
rs773794941 20 dbSNP
rs954807539 21 dbSNP
rs368411477 23 dbSNP
rs1402596094 24 dbSNP
rs767952131 27 dbSNP
rs776026049 32 dbSNP
rs761143948 38 dbSNP
rs1342871841 43 dbSNP
rs113218221 48 dbSNP
rs1469309589 49 dbSNP
rs1295383966 50 dbSNP
rs1392157244 57 dbSNP
rs1174754987 60 dbSNP
rs1466939450 61 dbSNP
rs1363575278 67 dbSNP
rs1018087047 72 dbSNP
rs1459339767 77 dbSNP
rs1294066288 78 dbSNP
rs1179286600 80 dbSNP
rs964682311 83 dbSNP
rs1441129356 88 dbSNP
rs1368323715 95 dbSNP
rs1238367391 97 dbSNP
rs968622711 97 dbSNP
rs1454705762 99 dbSNP
rs1182472429 101 dbSNP
rs1459545400 102 dbSNP
rs998005319 106 dbSNP
rs1200950299 110 dbSNP
rs1349749802 111 dbSNP
rs1381725514 130 dbSNP
rs1293695380 132 dbSNP
rs1258704034 137 dbSNP
rs978996513 140 dbSNP
rs532701668 147 dbSNP
rs950592441 150 dbSNP
rs758724708 166 dbSNP
rs983327166 171 dbSNP
rs909064347 174 dbSNP
rs748093120 176 dbSNP
rs1338775023 177 dbSNP
rs552788162 179 dbSNP
rs112189535 194 dbSNP
rs1333188795 195 dbSNP
rs1415526117 198 dbSNP
rs963261428 210 dbSNP
rs934527396 212 dbSNP
rs990739116 217 dbSNP
rs1421856493 222 dbSNP
rs992510279 236 dbSNP
rs1442301948 239 dbSNP
rs916888229 242 dbSNP
rs1238678752 248 dbSNP
rs879514252 251 dbSNP
rs1202924198 256 dbSNP
rs1264849515 265 dbSNP
rs528639824 266 dbSNP
rs1477964692 267 dbSNP
rs1218531656 268 dbSNP
rs569395528 270 dbSNP
rs948374891 271 dbSNP
rs1044174056 274 dbSNP
rs573859223 276 dbSNP
rs544421451 277 dbSNP
rs1245506583 280 dbSNP
rs888189470 283 dbSNP
rs1425349396 286 dbSNP
rs1165312154 287 dbSNP
rs1354398059 301 dbSNP
rs1344603760 316 dbSNP
rs1453128459 326 dbSNP
rs1296479404 328 dbSNP
rs1326383094 330 dbSNP
rs1296825647 337 dbSNP
rs949115816 340 dbSNP
rs1400797275 351 dbSNP
rs1361571059 361 dbSNP
rs1046560241 362 dbSNP
rs942246550 364 dbSNP
rs1415458536 365 dbSNP
rs1163356588 367 dbSNP
rs113878483 373 dbSNP
rs1037799127 376 dbSNP
rs1053264368 377 dbSNP
rs1312522567 380 dbSNP
rs1488529783 386 dbSNP
rs898083930 388 dbSNP
rs1377360143 392 dbSNP
rs993683505 402 dbSNP
rs1292233686 405 dbSNP
rs111555385 415 dbSNP
rs1230396583 415 dbSNP
rs1276940645 419 dbSNP
rs560526361 419 dbSNP
rs1030527144 423 dbSNP
rs1316891348 424 dbSNP
rs890480709 431 dbSNP
rs531924676 436 dbSNP
rs1017725385 437 dbSNP
rs1351267088 440 dbSNP
rs969174398 443 dbSNP
rs1287485334 444 dbSNP
rs1488342823 449 dbSNP
rs145992801 454 dbSNP
rs1209636401 455 dbSNP
rs1000037764 460 dbSNP
rs1254966050 461 dbSNP
rs1478090566 462 dbSNP
rs1428471082 469 dbSNP
rs1484108855 475 dbSNP
rs1478854770 482 dbSNP
rs1182291256 489 dbSNP
rs1248676063 491 dbSNP
rs1222583789 492 dbSNP
rs997553596 497 dbSNP
rs1256201284 498 dbSNP
rs1407136250 498 dbSNP
rs1319243532 508 dbSNP
rs1031483095 513 dbSNP
rs1030812673 529 dbSNP
rs886501372 530 dbSNP
rs1370172203 536 dbSNP
rs1005390680 537 dbSNP
rs1440993877 542 dbSNP
rs1374071607 544 dbSNP
rs1016070534 549 dbSNP
rs1010700082 551 dbSNP
rs990727832 560 dbSNP
rs1173785715 561 dbSNP
rs955951732 562 dbSNP
rs992769903 563 dbSNP
rs1023587790 565 dbSNP
rs970783084 565 dbSNP
rs1357712858 572 dbSNP
rs1450621103 589 dbSNP
rs565774048 590 dbSNP
rs1303830071 601 dbSNP
rs917151039 602 dbSNP
rs969788889 604 dbSNP
rs186953152 611 dbSNP
rs981779140 615 dbSNP
rs909639488 621 dbSNP
rs1263130579 623 dbSNP
rs1208619340 628 dbSNP
rs941066625 629 dbSNP
rs568591962 638 dbSNP
rs1037848461 640 dbSNP
rs923617231 641 dbSNP
rs1445143868 642 dbSNP
rs1312108434 643 dbSNP
rs1310926795 644 dbSNP
rs1353715290 644 dbSNP
rs919456516 650 dbSNP
rs1381398914 655 dbSNP
rs929458603 667 dbSNP
rs1233013048 668 dbSNP
rs989190055 672 dbSNP
rs1359630827 679 dbSNP
rs1052007296 684 dbSNP
rs1378703033 688 dbSNP
rs1210523959 699 dbSNP
rs1232053673 706 dbSNP
rs1440456463 713 dbSNP
rs534251593 713 dbSNP
rs890696957 718 dbSNP
rs1255529274 723 dbSNP
rs1039246228 724 dbSNP
rs1238510957 732 dbSNP
rs1215541125 736 dbSNP
rs1351878738 740 dbSNP
rs1007569757 744 dbSNP
rs1287799727 747 dbSNP
rs1240406633 750 dbSNP
rs1309991856 756 dbSNP
rs1358168677 756 dbSNP
rs1039408840 764 dbSNP
rs900776274 765 dbSNP
rs904626951 767 dbSNP
rs1397982273 768 dbSNP
rs1180369821 774 dbSNP
rs1238722185 792 dbSNP
rs1362200858 794 dbSNP
rs1000657581 801 dbSNP
rs1420503307 804 dbSNP
rs1368077862 810 dbSNP
rs933584752 812 dbSNP
rs1440397174 825 dbSNP
rs1031746320 827 dbSNP
rs1415169622 829 dbSNP
rs866192439 837 dbSNP
rs1193571136 838 dbSNP
rs1173160550 845 dbSNP
rs1487546497 846 dbSNP
rs955878495 847 dbSNP
rs1416339271 848 dbSNP
rs554219711 849 dbSNP
rs1487965569 852 dbSNP
rs1263255117 854 dbSNP
rs1024261528 855 dbSNP
rs1016391990 863 dbSNP
rs970345524 863 dbSNP
rs1012111112 869 dbSNP
rs1023493162 880 dbSNP
rs979794542 882 dbSNP
rs909514365 884 dbSNP
rs1278639089 886 dbSNP
rs1404060330 887 dbSNP
rs962393402 895 dbSNP
rs1291940613 897 dbSNP
rs982448527 910 dbSNP
rs570779546 911 dbSNP
rs918333816 913 dbSNP
rs956612102 923 dbSNP
rs879126286 926 dbSNP
rs989179995 930 dbSNP
rs1426348391 933 dbSNP
rs1194861878 944 dbSNP
rs13405185 949 dbSNP
rs1211246902 951 dbSNP
rs947538324 951 dbSNP
rs1488547567 955 dbSNP
rs1369146156 956 dbSNP
rs1219395539 958 dbSNP
rs1022047436 959 dbSNP
rs1196163198 961 dbSNP
rs1319947395 967 dbSNP
rs912151326 972 dbSNP
rs1232270008 983 dbSNP
rs1329135390 984 dbSNP
rs1299539026 986 dbSNP
rs13029837 989 dbSNP
rs1315764659 996 dbSNP
rs1368451233 1003 dbSNP
rs1464074964 1005 dbSNP
rs974857064 1009 dbSNP
rs943595804 1012 dbSNP
rs192288161 1017 dbSNP
rs1172005337 1023 dbSNP
rs558807696 1024 dbSNP
rs1258621226 1025 dbSNP
rs1465904773 1026 dbSNP
rs575385129 1027 dbSNP
rs933554669 1029 dbSNP
rs1433440391 1037 dbSNP
rs1237135018 1038 dbSNP
rs1468018899 1041 dbSNP
rs1176257835 1042 dbSNP
rs904549055 1044 dbSNP
rs1238792987 1050 dbSNP
rs1000176764 1052 dbSNP
rs1342672648 1053 dbSNP
rs1245003492 1056 dbSNP
rs544370427 1060 dbSNP
rs1128804 1067 dbSNP
rs1233655381 1071 dbSNP
rs907863300 1073 dbSNP
rs760797659 1082 dbSNP
rs891877672 1107 dbSNP
rs1419157567 1109 dbSNP
rs1014103765 1114 dbSNP
rs1379190660 1116 dbSNP
rs940701328 1120 dbSNP
rs1464379491 1121 dbSNP
rs1024519083 1122 dbSNP
rs905798064 1127 dbSNP
rs1037772848 1133 dbSNP
rs370980653 1137 dbSNP
rs574207830 1138 dbSNP
rs1401619096 1148 dbSNP
rs1461344674 1154 dbSNP
rs1012351650 1156 dbSNP
rs1156457328 1165 dbSNP
rs1044872470 1166 dbSNP
rs1016834905 1169 dbSNP
rs745723321 1169 dbSNP
rs1351058808 1179 dbSNP
rs962731361 1186 dbSNP
rs1258124407 1193 dbSNP
rs1200825846 1206 dbSNP
rs1436580791 1208 dbSNP
rs145190700 1213 dbSNP
rs1238219308 1215 dbSNP
rs771299538 1217 dbSNP
rs1003462576 1218 dbSNP
rs1339238111 1221 dbSNP
rs1336645580 1227 dbSNP
rs1220217831 1235 dbSNP
rs1360278788 1240 dbSNP
rs1278556960 1247 dbSNP
rs1421109119 1248 dbSNP
rs1380488735 1259 dbSNP
rs1333914733 1267 dbSNP
rs539898525 1276 dbSNP
rs1471483981 1285 dbSNP
rs1370188413 1302 dbSNP
rs559720129 1312 dbSNP
rs955088382 1313 dbSNP
rs1260726025 1314 dbSNP
rs1291938123 1320 dbSNP
rs1453397269 1322 dbSNP
rs1489405925 1323 dbSNP
rs956384101 1332 dbSNP
rs1222477929 1333 dbSNP
rs1354332193 1337 dbSNP
rs532128474 1339 dbSNP
rs912020670 1340 dbSNP
rs1276738330 1341 dbSNP
rs1402188352 1348 dbSNP
rs1345434960 1357 dbSNP
rs1322465726 1360 dbSNP
rs1403153712 1362 dbSNP
rs1392227519 1364 dbSNP
rs1165608064 1374 dbSNP
rs1477472834 1385 dbSNP
rs1421329437 1386 dbSNP
rs1476986368 1388 dbSNP
rs1196159892 1389 dbSNP
rs750499530 1392 dbSNP
rs1242983398 1405 dbSNP
rs1491552084 1409 dbSNP
rs963734957 1409 dbSNP
rs1332424767 1410 dbSNP
rs140942617 1410 dbSNP
rs184011191 1410 dbSNP
rs796641866 1410 dbSNP
rs1464596628 1412 dbSNP
rs185020446 1412 dbSNP
rs529149034 1419 dbSNP
rs1398028689 1424 dbSNP
rs926222478 1428 dbSNP
rs34629315 1429 dbSNP
rs936019708 1434 dbSNP
rs1172728613 1445 dbSNP
rs139936917 1448 dbSNP
rs765580658 1451 dbSNP
rs1424182825 1456 dbSNP
rs1172254740 1459 dbSNP
rs940941451 1463 dbSNP
rs556831975 1464 dbSNP
rs1405436732 1467 dbSNP
rs1457322969 1469 dbSNP
rs1236942316 1481 dbSNP
rs1317084655 1485 dbSNP
rs891887433 1496 dbSNP
rs950089149 1499 dbSNP
rs920604551 1500 dbSNP
rs1217784796 1503 dbSNP
rs1346699209 1507 dbSNP
rs1045582167 1512 dbSNP
rs1298442876 1513 dbSNP
rs905715191 1515 dbSNP
rs1445483648 1517 dbSNP
rs548815688 1518 dbSNP
rs189587132 1519 dbSNP
rs1442797328 1523 dbSNP
rs1358464331 1534 dbSNP
rs527790885 1543 dbSNP
rs898386485 1553 dbSNP
rs1174481347 1558 dbSNP
rs1320803169 1581 dbSNP
rs1378515106 1581 dbSNP
rs1052342569 1583 dbSNP
rs993799119 1589 dbSNP
rs892358403 1591 dbSNP
rs753049857 1594 dbSNP
rs1025243164 1599 dbSNP
rs1208464732 1600 dbSNP
rs547911378 1607 dbSNP
rs1010790337 1608 dbSNP
rs1285868279 1610 dbSNP
rs1350918507 1619 dbSNP
rs1310854443 1620 dbSNP
rs955140607 1621 dbSNP
rs530554346 1622 dbSNP
rs764545774 1626 dbSNP
rs78171211 1629 dbSNP
rs749962845 1636 dbSNP
rs1029855100 1647 dbSNP
rs1313756973 1649 dbSNP
rs1419360155 1651 dbSNP
rs954883255 1666 dbSNP
rs1285348519 1674 dbSNP
rs988022277 1676 dbSNP
rs908049845 1677 dbSNP
rs1487363226 1680 dbSNP
rs1180608762 1681 dbSNP
rs1476420899 1705 dbSNP
rs113131152 1706 dbSNP
rs965285009 1717 dbSNP
rs1216295866 1720 dbSNP
rs962256040 1726 dbSNP
rs1442204003 1727 dbSNP
rs973655381 1730 dbSNP
rs1320590828 1731 dbSNP
rs1185944388 1734 dbSNP
rs1310544959 1734 dbSNP
rs920593335 1735 dbSNP
rs1473437492 1741 dbSNP
rs368716197 1742 dbSNP
rs570175889 1742 dbSNP
rs552220046 1755 dbSNP
rs1290849287 1756 dbSNP
rs1454424038 1757 dbSNP
rs1349351711 1758 dbSNP
rs755673138 1763 dbSNP
rs939468491 1766 dbSNP
rs1263495904 1768 dbSNP
rs143258459 1768 dbSNP
rs1374534068 1770 dbSNP
rs1043663455 1774 dbSNP
rs779511157 1780 dbSNP
rs1263200494 1781 dbSNP
rs988829469 1784 dbSNP
rs1335403023 1785 dbSNP
rs913206440 1790 dbSNP
rs1340877049 1791 dbSNP
rs996940528 1796 dbSNP
rs1441331039 1807 dbSNP
rs1029349311 1811 dbSNP
rs950013556 1814 dbSNP
rs11901227 1816 dbSNP
rs554351517 1819 dbSNP
rs1351517743 1828 dbSNP
rs752532457 1829 dbSNP
rs1286997780 1840 dbSNP
rs1344641461 1843 dbSNP
rs182275100 1849 dbSNP
rs1395866836 1850 dbSNP
rs1258660208 1856 dbSNP
rs1038169257 1860 dbSNP
rs962246230 1868 dbSNP
rs1375121353 1875 dbSNP
rs973646836 1877 dbSNP
rs1178489475 1878 dbSNP
rs1264751669 1879 dbSNP
rs1027935088 1885 dbSNP
rs969357378 1913 dbSNP
rs1237553021 1920 dbSNP
rs533686349 1921 dbSNP
rs1196650216 1923 dbSNP
rs777420584 1927 dbSNP
rs1178766723 1930 dbSNP
rs1232196987 1934 dbSNP
rs553821117 1935 dbSNP
rs994018566 1938 dbSNP
rs939397627 1943 dbSNP
rs1331321438 1950 dbSNP
rs913734650 1953 dbSNP
rs1046954124 1955 dbSNP
rs946586391 1956 dbSNP
rs1043606116 1957 dbSNP
rs576798740 1963 dbSNP
rs1379101175 1964 dbSNP
rs1175112522 1970 dbSNP
rs1449064714 1971 dbSNP
rs1454371815 1972 dbSNP
rs932600006 1973 dbSNP
rs562796185 1976 dbSNP
rs1439515989 1979 dbSNP
rs1251082724 1986 dbSNP
rs1018473114 1993 dbSNP
rs576154757 1993 dbSNP
rs1231277378 1995 dbSNP
rs139201057 1997 dbSNP
rs1348744763 2003 dbSNP
rs756876806 2008 dbSNP
rs897984698 2011 dbSNP
rs1027840556 2013 dbSNP
rs777803111 2015 dbSNP
rs1412783805 2016 dbSNP
rs981053566 2017 dbSNP
rs957621997 2022 dbSNP
rs1314372229 2028 dbSNP
rs989091207 2036 dbSNP
rs1035392765 2041 dbSNP
rs1198475613 2043 dbSNP
rs913484010 2045 dbSNP
rs1156320410 2046 dbSNP
rs971422375 2050 dbSNP
rs981433825 2052 dbSNP
rs988623432 2053 dbSNP
rs1421890646 2059 dbSNP
rs1259319208 2061 dbSNP
rs927375134 2063 dbSNP
rs780732662 2065 dbSNP
rs1285491417 2067 dbSNP
rs1038626625 2074 dbSNP
rs1459509482 2076 dbSNP
rs968123297 2077 dbSNP
rs1199857872 2078 dbSNP
rs1354067949 2083 dbSNP
rs979206522 2083 dbSNP
rs1415721943 2087 dbSNP
rs1265997827 2095 dbSNP
rs1162635040 2097 dbSNP
rs1385028955 2097 dbSNP
rs367623671 2097 dbSNP
rs1456362280 2101 dbSNP
rs932523354 2107 dbSNP
rs542495650 2113 dbSNP
rs912208612 2114 dbSNP
rs1262811597 2116 dbSNP
rs1191274201 2119 dbSNP
rs61679785 2121 dbSNP
rs1209265541 2127 dbSNP
rs1047004293 2137 dbSNP
rs1167337085 2138 dbSNP
rs771172865 2146 dbSNP
rs527879994 2148 dbSNP
rs1317673424 2153 dbSNP
rs1008313995 2160 dbSNP
rs1402333440 2162 dbSNP
rs898221819 2165 dbSNP
rs1039331538 2174 dbSNP
rs1432425802 2175 dbSNP
rs1326616645 2178 dbSNP
rs16831745 2179 dbSNP
rs1437990774 2180 dbSNP
rs1325167736 2183 dbSNP
rs1000592231 2185 dbSNP
rs1464950227 2189 dbSNP
rs1390016276 2198 dbSNP
rs1421164841 2205 dbSNP
rs1169390949 2206 dbSNP
rs1476525471 2214 dbSNP
rs1242859528 2216 dbSNP
rs1385225117 2219 dbSNP
rs1032080578 2221 dbSNP
rs759692580 2227 dbSNP
rs745405912 2233 dbSNP
rs1214843283 2234 dbSNP
rs1331946073 2242 dbSNP
rs1457633383 2244 dbSNP
rs1271368685 2246 dbSNP
rs1218372701 2255 dbSNP
rs1276653399 2256 dbSNP
rs1320470714 2262 dbSNP
rs564584988 2270 dbSNP
rs1273871761 2276 dbSNP
rs1231513883 2280 dbSNP
rs1372510132 2287 dbSNP
rs1002865672 2297 dbSNP
rs71396305 2297 dbSNP
rs72017913 2297 dbSNP
rs768385365 2297 dbSNP
rs1352641668 2299 dbSNP
rs1330654017 2300 dbSNP
rs960978210 2301 dbSNP
rs3176 2303 dbSNP
rs957564852 2307 dbSNP
rs1265375662 2310 dbSNP
rs1173237555 2330 dbSNP
rs1010402041 2331 dbSNP
rs1020557036 2332 dbSNP
rs971634368 2334 dbSNP
rs1211178542 2342 dbSNP
rs1009500082 2349 dbSNP
rs1438736873 2360 dbSNP
rs1277532744 2365 dbSNP
rs186835785 2367 dbSNP
rs142487496 2372 dbSNP
rs958946512 2373 dbSNP
rs150934639 2378 dbSNP
rs1191107259 2383 dbSNP
rs920006338 2391 dbSNP
rs929843166 2392 dbSNP
rs1442734550 2394 dbSNP
rs548043969 2394 dbSNP
rs1163981249 2395 dbSNP
rs1433129895 2402 dbSNP
rs1377456404 2407 dbSNP
rs1046844722 2410 dbSNP
rs912480977 2412 dbSNP
rs537749338 2413 dbSNP
rs3175 2420 dbSNP
rs768349118 2421 dbSNP
rs1470738400 2438 dbSNP
rs1257294095 2446 dbSNP
rs1366304684 2451 dbSNP
rs899526036 2452 dbSNP
rs1186195781 2453 dbSNP
rs936316590 2454 dbSNP
rs567953776 2457 dbSNP
rs1215344244 2458 dbSNP
rs1314601913 2464 dbSNP
rs1377386585 2466 dbSNP
rs1296596318 2467 dbSNP
rs912501840 2468 dbSNP
rs533723444 2469 dbSNP
rs892185852 2470 dbSNP
rs972321567 2473 dbSNP
rs1313694202 2474 dbSNP
rs1010413565 2476 dbSNP
rs553612874 2481 dbSNP
rs576888132 2483 dbSNP
rs1003158327 2484 dbSNP
rs1186259170 2485 dbSNP
rs1417701033 2485 dbSNP
rs1476389081 2489 dbSNP
rs1257859466 2492 dbSNP
rs1185551535 2494 dbSNP
rs1484631081 2498 dbSNP
rs764423472 2499 dbSNP
rs919601739 2504 dbSNP
rs192727882 2505 dbSNP
rs974033713 2506 dbSNP
rs931012794 2507 dbSNP
rs78430840 2512 dbSNP
rs1027032768 2515 dbSNP
rs905352130 2517 dbSNP
rs183628340 2518 dbSNP
rs982597042 2520 dbSNP
rs1213939098 2531 dbSNP
rs1057053141 2532 dbSNP
rs1264963176 2532 dbSNP
rs1290725183 2533 dbSNP
rs896706383 2539 dbSNP
rs141087876 2545 dbSNP
rs1163386879 2546 dbSNP
rs1463391677 2546 dbSNP
rs1170142650 2547 dbSNP
rs778657534 2549 dbSNP
rs968058637 2553 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL35
Disease MIMAT0005949
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020022. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acauccgaccCCUAUUUACUUau 5'
                    || |||:||::  
Target 5' ------uucaGGCUAAGUGGGaa 3'
 		1 - 17
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020022
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL35 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000326446.5 | 3UTR | UUCAGGCUAAGUGGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells -0.444 1.7e-2 -0.432 2.0e-2 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.402 2.3e-2 -0.286 8.3e-2 25 Click to see details
GSE28260 Renal cortex and medulla 0.535 3.0e-2 0.593 1.6e-2 13 Click to see details
GSE28544 Breast cancer 0.333 5.6e-2 0.732 2.4e-5 24 Click to see details
GSE32688 Pancreatic cancer 0.121 2.5e-1 0.173 1.7e-1 32 Click to see details
GSE38226 Liver fibrosis -0.144 2.7e-1 -0.068 3.8e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.02 4.6e-1 0.053 4.0e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.463 0 -0.413 0 59 Click to see details
BLCA 0.608 0 0.480 0.02 18 Click to see details
KIRC -0.286 0.01 -0.270 0.01 68 Click to see details
HNSC -0.35 0.01 -0.237 0.07 42 Click to see details
LUSC -0.327 0.02 -0.212 0.1 38 Click to see details
STAD 0.336 0.03 0.276 0.06 32 Click to see details
LIHC -0.232 0.05 -0.144 0.16 49 Click to see details
PCPG -0.983 0.06 -0.500 0.33 3 Click to see details
KICH -0.307 0.07 -0.037 0.43 25 Click to see details
COAD -0.55 0.08 -0.643 0.04 8 Click to see details
PRAD -0.202 0.08 -0.075 0.3 50 Click to see details
PAAD 0.682 0.16 0.600 0.2 4 Click to see details
LUAD -0.255 0.21 -0.154 0.32 12 Click to see details
BRCA 0.086 0.22 0.165 0.07 84 Click to see details
UCEC 0.155 0.26 0.068 0.39 19 Click to see details
ESCA 0.168 0.31 0.045 0.45 11 Click to see details
CHOL -0.104 0.4 -0.200 0.3 9 Click to see details
CESC 0.102 0.47 0.500 0.33 3 Click to see details
KIRP -0.014 0.47 -0.051 0.39 32 Click to see details
KIRP -0.014 0.47 -0.051 0.39 32 Click to see details
KIRP -0.014 0.47 -0.051 0.39 32 Click to see details
88 hsa-miR-664a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035824 HIAT1 major facilitator superfamily domain containing 14A 1 1
MIRT035826 FUS FUS RNA binding protein 1 1
MIRT069432 SIVA1 SIVA1 apoptosis inducing factor 2 2
MIRT071494 CALM1 calmodulin 1 2 2
MIRT100410 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT143469 CHD9 chromodomain helicase DNA binding protein 9 2 2
MIRT191113 ARF6 ADP ribosylation factor 6 2 2
MIRT235584 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT339131 ARID1A AT-rich interaction domain 1A 2 2
MIRT437450 MAT1A methionine adenosyltransferase 1A 1 1
MIRT442234 BTD biotinidase 2 2
MIRT443321 SLC35G1 solute carrier family 35 member G1 2 2
MIRT443769 HLF HLF, PAR bZIP transcription factor 2 2
MIRT444352 KIAA1211 KIAA1211 2 2
MIRT456348 OLIG3 oligodendrocyte transcription factor 3 2 8
MIRT458866 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT466169 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT470445 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 6
MIRT471524 PCGF3 polycomb group ring finger 3 2 6
MIRT477744 EDN1 endothelin 1 2 2
MIRT482885 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT496336 PTPRT protein tyrosine phosphatase, receptor type T 2 2
MIRT497703 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT499068 CTBP1 C-terminal binding protein 1 2 4
MIRT500296 ZNF667 zinc finger protein 667 2 8
MIRT500506 ZBTB34 zinc finger and BTB domain containing 34 2 8
MIRT501964 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT505457 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT505955 RAN RAN, member RAS oncogene family 2 6
MIRT507512 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT512953 MKI67 marker of proliferation Ki-67 2 2
MIRT520450 TSPAN2 tetraspanin 2 2 6
MIRT525997 MAGEL2 MAGE family member L2 2 2
MIRT526424 ZNF695 zinc finger protein 695 2 2
MIRT527364 KRTAP13-2 keratin associated protein 13-2 2 2
MIRT529612 H1F0 H1 histone family member 0 2 2
MIRT529811 TMLHE trimethyllysine hydroxylase, epsilon 2 2
MIRT530971 EXO5 exonuclease 5 2 4
MIRT531294 WNT7A Wnt family member 7A 2 2
MIRT531870 POF1B premature ovarian failure, 1B 2 2
MIRT532116 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT533534 TPR translocated promoter region, nuclear basket protein 2 2
MIRT545934 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546649 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT548063 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT548288 FAM3C family with sequence similarity 3 member C 2 4
MIRT551018 SPPL3 signal peptide peptidase like 3 2 2
MIRT551139 ZNF678 zinc finger protein 678 2 2
MIRT552398 ZNF487P zinc finger protein 487 1 1
MIRT555640 PHIP pleckstrin homology domain interacting protein 2 4
MIRT556267 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT558864 CD2AP CD2 associated protein 2 2
MIRT559239 BEND4 BEN domain containing 4 2 2
MIRT559438 ARSJ arylsulfatase family member J 2 2
MIRT559793 ZNF415 zinc finger protein 415 2 2
MIRT562572 CBX6 chromobox 6 2 2
MIRT562741 ZNF83 zinc finger protein 83 2 2
MIRT564737 ZNF23 zinc finger protein 23 2 2
MIRT565174 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT566301 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT571656 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT610720 NAV2 neuron navigator 2 2 2
MIRT611486 ADCYAP1R1 ADCYAP receptor type I 2 4
MIRT617118 KANK2 KN motif and ankyrin repeat domains 2 2 2
MIRT617836 SIGLEC10 sialic acid binding Ig like lectin 10 2 2
MIRT636145 VLDLR very low density lipoprotein receptor 2 2
MIRT638060 YAE1D1 Yae1 domain containing 1 2 4
MIRT640159 CDK13 cyclin dependent kinase 13 2 2
MIRT644257 WEE2 WEE1 homolog 2 2 2
MIRT646838 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT653074 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2 2
MIRT657671 GPR26 G protein-coupled receptor 26 2 2
MIRT660601 AP3M2 adaptor related protein complex 3 mu 2 subunit 2 2
MIRT668908 CREB1 cAMP responsive element binding protein 1 2 2
MIRT672685 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT680977 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682271 RS1 retinoschisin 1 2 2
MIRT702058 RNMT RNA guanine-7 methyltransferase 2 2
MIRT707786 UNK unkempt family zinc finger 2 2
MIRT709238 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710119 MED23 mediator complex subunit 23 2 2
MIRT710675 ADAP2 ArfGAP with dual PH domains 2 2 2
MIRT712884 NIPBL NIPBL, cohesin loading factor 2 2
MIRT719015 HPGD 15-hydroxyprostaglandin dehydrogenase 2 2
MIRT723323 COLEC10 collectin subfamily member 10 2 2
MIRT724947 TXNL1 thioredoxin like 1 2 2
MIRT725535 EN2 engrailed homeobox 2 2 2
MIRT734156 FHL1 four and a half LIM domains 1 3 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-664a Plx-4720 24180719 NSC757438 resistant High Thyroid Cancer cell line (8505c, BCPAP)
hsa-mir-664a Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-664a Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-664a-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HT-29)
hsa-miR-664a-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-664a-3p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-664a-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC7901)
hsa-miR-664a-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-664a-3p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-miR-664a-3p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-664a-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-664a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-664a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-664a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-664a-3p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-664a-3p Fluorouracil 3385 NSC19893 approved resistant cell line (HCT15)
hsa-miR-664a-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-664a-3p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-664a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-664a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-664a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-664a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-664a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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