miRTarBase - #MIRT497840


—
pre-miRNA Information
pre-miRNA hsa-mir-3194   
Genomic Coordinates chr20: 51452905 - 51452977
Description Homo sapiens miR-3194 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3194-5p
Sequence 10| GGCCAGCCACCAGGAGGGCUG |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1344875175 4 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHD1   
Synonyms -
Description chromodomain helicase DNA binding protein 1
Transcript NM_001270   
Expression
Putative miRNA Targets on CHD1
3'UTR of CHD1
(miRNA target sites are highlighted)		 
>CHD1|NM_001270|3'UTR
   1 CAAAAACTGATACTTCGTCTTTCTGGACTTTTCTTTTAGCCATATATCATAAACCAACACAGTAATTGCCTTACATGACT
  81 TGAAAGATATAAACAGATCTTCTATCAGTAGCAGTATTGTTACTTCTTTCCAGGATGCAAGGTCTATTATCCCAACAGAA
 161 GAGAAAATATTTTTATATTTAAGGATTATGCTGCACTGTACTACAAAATTGTAGTACTTTTTTTTGTTTTCTTTTTTAAA
 241 GAAATGGAAAATGTTTACTATTACAGGGACCTCAACACTGCCCTCCCATACAGGCTGGATAAAACTGTTTTTAAGTCAGT
 321 GATTTTAGACTGACCTCCATTTAAATTATGTTTATATATGAACTTTACTCTGACCTGTGATCATGTTTCAGGAAGGAATG
 401 AAAGAGAGTTCTTTCTTAATAAAGAAAAACACTCAAGGACTTTGTTCATTTCCAAAGCTACTTGTTTACATTGTACACTG
 481 CGACCACCTTGCCGCTTTTCATCACAAGCTTGAATATTTAAATTCTGTACTTATATCTGTAAAATAGCCAGGAATTTCCT
 561 GTTTGTGATCTATTATGCCTTTTTACAAAAAAAATGGCTGTAAATTATTGTAAATATTAAAGGAACTTTCCTTACTTCCT
 641 TCCCTTTCTCAGGCTTTTTTTGACTGTTCCTTTCCCTACCAACTCAGGCCTTCTTATTAAAAAAAAAAAAATCAGTGTAA
 721 TAACACTTTTTAATGATTTGTCTTGATGGAATCATTGTTTAGAATGTAAAAATGGGGAAAGGGGCCACTTAATTCCATTA
 801 GTCCTCTTTTTATACTGAATATTTTATTAGATACATGTTATTCCCTTTTTTTTCCTTTTTTAGTCAATATTGTGTTTGTA
 881 GTTTTAAAAAATGGCGAGATATGTAAAATCTAAACTGCATGCTCTGGAAACACTTTTTTCAGATGCATCTGGTTTAAAAG
 961 GGTAGGTGTATAAACACTTTTCAGAATCCAAAACGGCCAAAAGTTATTGTAAATCCGTTTGTTTTCCCGTTTTATGTGGG
1041 CAATAATGTCAAATGTGCTATGCAGCCAGGTTAACATTTTAGATAAACTTGATTGACTTTTAATATAAACTGTTACAATG
1121 CACACTGATTGTATATAAAAACGTTATATATGACAAATTAAATTTAAGAAAAAGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guCGGGAGG--ACCACCGACCgg 5'
            |||||||  |   ||||||  
Target 5' ctGCCCTCCCATACAGGCTGGat 3'
 278 - 300 141.00 -23.20
2 
miRNA  3' gucgggaggaccACCGACcgg 5'
                      ||||||   
Target 5' ttacaaaaaaaaTGGCTGtaa 3'
 583 - 603 105.00 -8.20
3 
miRNA  3' gucGGGAGGACCACCGAccgg 5'
             ||:|:||   ||||    
Target 5' ttcCCTTTCT-CAGGCTtttt 3'
 640 - 659 93.00 -10.66
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30538025 3 COSMIC
COSN30523149 16 COSMIC
COSN30544460 80 COSMIC
COSN16941714 87 COSMIC
COSN30129553 103 COSMIC
COSN30493863 166 COSMIC
COSN29789068 193 COSMIC
COSN28842857 218 COSMIC
COSN30165859 233 COSMIC
COSN9961366 347 COSMIC
COSN29793596 426 COSMIC
COSN29062153 699 COSMIC
COSN16444001 720 COSMIC
COSN19429009 957 COSMIC
COSN4950682 994 COSMIC
COSN26504833 1143 COSMIC
COSN19137194 1375 COSMIC
COSN26865713 1540 COSMIC
COSN23708982 2026 COSMIC
COSN9198681 2225 COSMIC
COSN23471060 2327 COSMIC
rs2455425 348 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1361436530 2 dbSNP
rs1306993431 3 dbSNP
rs1390563582 7 dbSNP
rs761056581 8 dbSNP
rs1299711668 10 dbSNP
rs1046169194 11 dbSNP
rs773372971 12 dbSNP
rs1163648177 13 dbSNP
rs767701099 16 dbSNP
rs374487266 17 dbSNP
rs774285846 18 dbSNP
rs749584176 31 dbSNP
rs780369983 38 dbSNP
rs1179391662 40 dbSNP
rs564481901 41 dbSNP
rs745729064 42 dbSNP
rs1223229830 43 dbSNP
rs776665880 44 dbSNP
rs906634914 46 dbSNP
rs151025302 53 dbSNP
rs753145544 55 dbSNP
rs1255374245 63 dbSNP
rs571657878 74 dbSNP
rs527798673 79 dbSNP
rs142796969 88 dbSNP
rs542018738 90 dbSNP
rs1406898245 91 dbSNP
rs1398597855 92 dbSNP
rs935863455 94 dbSNP
rs1345292286 98 dbSNP
rs764526375 102 dbSNP
rs761013030 104 dbSNP
rs989792669 108 dbSNP
rs574692812 113 dbSNP
rs1467873271 114 dbSNP
rs1354176868 119 dbSNP
rs967556522 122 dbSNP
rs1285161751 131 dbSNP
rs189315446 146 dbSNP
rs943336740 150 dbSNP
rs910377448 152 dbSNP
rs556482902 179 dbSNP
rs987327199 186 dbSNP
rs1354650535 189 dbSNP
rs1210348713 206 dbSNP
rs1272432865 209 dbSNP
rs1278262361 212 dbSNP
rs544489915 215 dbSNP
rs1486616964 216 dbSNP
rs1211422565 226 dbSNP
rs976859208 226 dbSNP
rs1468363504 228 dbSNP
rs1178702704 229 dbSNP
rs954413475 229 dbSNP
rs1219866689 231 dbSNP
rs765856601 233 dbSNP
rs963757273 245 dbSNP
rs1171217040 255 dbSNP
rs1373231583 264 dbSNP
rs762436546 273 dbSNP
rs1376673970 276 dbSNP
rs558141644 278 dbSNP
rs1437159556 282 dbSNP
rs1301569209 288 dbSNP
rs1354444357 292 dbSNP
rs1440357914 301 dbSNP
rs576794593 326 dbSNP
rs558546913 332 dbSNP
rs1007785934 333 dbSNP
rs971829701 335 dbSNP
rs2455425 348 dbSNP
rs1015963926 358 dbSNP
rs185704335 367 dbSNP
rs1219764934 369 dbSNP
rs1169191595 383 dbSNP
rs1434823250 389 dbSNP
rs1272266699 395 dbSNP
rs554320730 406 dbSNP
rs993605692 406 dbSNP
rs1396319493 415 dbSNP
rs774672080 418 dbSNP
rs1238501066 428 dbSNP
rs116517844 432 dbSNP
rs1191317381 434 dbSNP
rs1396384091 438 dbSNP
rs1251059315 448 dbSNP
rs1178697701 455 dbSNP
rs1034230379 458 dbSNP
rs1419505842 466 dbSNP
rs1003680401 471 dbSNP
rs1331312881 472 dbSNP
rs1401400287 474 dbSNP
rs894477816 482 dbSNP
rs1324079791 492 dbSNP
rs1210684543 493 dbSNP
rs1055780691 494 dbSNP
rs1437332380 502 dbSNP
rs935916746 505 dbSNP
rs1337383267 506 dbSNP
rs1350146444 525 dbSNP
rs1216187655 533 dbSNP
rs192832259 534 dbSNP
rs139918850 554 dbSNP
rs1254535629 555 dbSNP
rs1354674949 559 dbSNP
rs1309653967 570 dbSNP
rs1009637349 576 dbSNP
rs1239807074 578 dbSNP
rs1390006186 580 dbSNP
rs78170927 587 dbSNP
rs575030163 589 dbSNP
rs1474718013 593 dbSNP
rs1170111158 595 dbSNP
rs529494226 595 dbSNP
rs893793034 595 dbSNP
rs1163188048 596 dbSNP
rs922394986 596 dbSNP
rs976533335 598 dbSNP
rs1406157919 601 dbSNP
rs1303962556 604 dbSNP
rs200593622 610 dbSNP
rs1317731506 619 dbSNP
rs1324719874 630 dbSNP
rs759648095 634 dbSNP
rs1376809241 644 dbSNP
rs1354703511 656 dbSNP
rs1231295439 662 dbSNP
rs1310540053 680 dbSNP
rs768367400 685 dbSNP
rs1433759930 686 dbSNP
rs910903521 690 dbSNP
rs1053833517 699 dbSNP
rs1281568130 706 dbSNP
rs75359567 711 dbSNP
rs1193731812 712 dbSNP
rs1264581825 712 dbSNP
rs1266183445 712 dbSNP
rs1448176025 712 dbSNP
rs1475165315 712 dbSNP
rs34796114 712 dbSNP
rs398050586 712 dbSNP
rs1458631901 713 dbSNP
rs943244030 714 dbSNP
rs910481319 720 dbSNP
rs1383041251 724 dbSNP
rs1402563708 729 dbSNP
rs1298875237 732 dbSNP
rs1363999431 735 dbSNP
rs1374832540 736 dbSNP
rs1051571641 741 dbSNP
rs1160783465 742 dbSNP
rs1294911629 751 dbSNP
rs1340808475 753 dbSNP
rs933120109 754 dbSNP
rs919119913 760 dbSNP
rs971798688 766 dbSNP
rs963162785 767 dbSNP
rs1277463350 768 dbSNP
rs908830931 771 dbSNP
rs1352356852 781 dbSNP
rs776685077 781 dbSNP
rs1278977335 791 dbSNP
rs1485639097 812 dbSNP
rs1209305096 819 dbSNP
rs532467831 843 dbSNP
rs1424806765 846 dbSNP
rs1033958584 849 dbSNP
rs1024854212 854 dbSNP
rs1362344944 854 dbSNP
rs1003768502 861 dbSNP
rs1159338605 862 dbSNP
rs970839618 865 dbSNP
rs1014358489 869 dbSNP
rs1188581702 872 dbSNP
rs1021084905 879 dbSNP
rs1402799245 880 dbSNP
rs1390648476 884 dbSNP
rs1486601413 891 dbSNP
rs1009565499 895 dbSNP
rs1255575864 899 dbSNP
rs1337223547 901 dbSNP
rs1240348527 902 dbSNP
rs893927991 903 dbSNP
rs1054186377 904 dbSNP
rs571415381 908 dbSNP
rs894522443 919 dbSNP
rs1345053746 921 dbSNP
rs1235820451 924 dbSNP
rs1258329169 926 dbSNP
rs1488767236 934 dbSNP
rs1195643182 940 dbSNP
rs1459259402 940 dbSNP
rs1483861055 940 dbSNP
rs552549342 940 dbSNP
rs1179456382 942 dbSNP
rs1262736974 943 dbSNP
rs772198625 952 dbSNP
rs1178291215 961 dbSNP
rs1452716180 961 dbSNP
rs904475682 963 dbSNP
rs1041666419 970 dbSNP
rs1007584596 977 dbSNP
rs1313868839 978 dbSNP
rs945915792 980 dbSNP
rs1235749252 982 dbSNP
rs1294558171 982 dbSNP
rs1447088216 985 dbSNP
rs561453710 987 dbSNP
rs1442554429 991 dbSNP
rs1301341710 992 dbSNP
rs1051653985 1000 dbSNP
rs933234416 1003 dbSNP
rs942496679 1007 dbSNP
rs910950907 1009 dbSNP
rs983789255 1016 dbSNP
rs529310149 1017 dbSNP
rs918217598 1021 dbSNP
rs1451107782 1025 dbSNP
rs1036237357 1029 dbSNP
rs1268077843 1032 dbSNP
rs1427855901 1036 dbSNP
rs745940620 1040 dbSNP
rs779177439 1043 dbSNP
rs544848789 1047 dbSNP
rs1163940994 1052 dbSNP
rs908991345 1053 dbSNP
rs569611445 1054 dbSNP
rs549889479 1056 dbSNP
rs993392647 1058 dbSNP
rs1360609552 1059 dbSNP
rs1382182332 1060 dbSNP
rs1187074604 1077 dbSNP
rs991543997 1083 dbSNP
rs958374883 1090 dbSNP
rs1219708242 1091 dbSNP
rs867454912 1095 dbSNP
rs928301324 1097 dbSNP
rs1332983525 1101 dbSNP
rs982293498 1114 dbSNP
rs1485611772 1116 dbSNP
rs763444141 1116 dbSNP
rs1034426621 1118 dbSNP
rs1000248631 1119 dbSNP
rs1478098674 1120 dbSNP
rs1186971372 1127 dbSNP
rs904528114 1133 dbSNP
rs970954604 1133 dbSNP
rs1485663218 1136 dbSNP
rs1274243491 1142 dbSNP
rs1010169755 1147 dbSNP
rs1021073590 1149 dbSNP
rs749500789 1152 dbSNP
rs1451051486 1154 dbSNP
rs1299496627 1165 dbSNP
rs1363074287 1168 dbSNP
rs1378014208 1171 dbSNP
rs1215919545 1172 dbSNP
rs1293070097 1176 dbSNP
rs796667420 1179 dbSNP
rs1293250839 1187 dbSNP
rs1032405722 1189 dbSNP
rs1040909286 1215 dbSNP
rs1316549972 1215 dbSNP
rs1008072396 1216 dbSNP
rs1297075561 1218 dbSNP
rs942522927 1219 dbSNP
rs367881297 1221 dbSNP
rs889090641 1224 dbSNP
rs1488577456 1227 dbSNP
rs1182205877 1228 dbSNP
rs560679935 1228 dbSNP
rs769929336 1228 dbSNP
rs931023537 1229 dbSNP
rs918270049 1231 dbSNP
rs997432115 1235 dbSNP
rs1462836577 1238 dbSNP
rs1357897786 1239 dbSNP
rs953780512 1241 dbSNP
rs1303775841 1242 dbSNP
rs77918687 1242 dbSNP
rs940981349 1242 dbSNP
rs35736545 1243 dbSNP
rs1164132955 1248 dbSNP
rs147480848 1254 dbSNP
rs958868784 1255 dbSNP
rs1374927563 1260 dbSNP
rs1276470501 1265 dbSNP
rs562723163 1266 dbSNP
rs1428194305 1268 dbSNP
rs887624278 1269 dbSNP
rs371112651 1282 dbSNP
rs144756254 1283 dbSNP
rs577482601 1285 dbSNP
rs928262732 1304 dbSNP
rs1238275376 1312 dbSNP
rs1453321630 1314 dbSNP
rs1171195204 1315 dbSNP
rs1423750347 1318 dbSNP
rs1416598368 1322 dbSNP
rs1177246019 1324 dbSNP
rs1272886528 1326 dbSNP
rs1354268237 1328 dbSNP
rs1444864524 1331 dbSNP
rs1333671009 1333 dbSNP
rs1377892252 1338 dbSNP
rs1440353032 1344 dbSNP
rs140480373 1345 dbSNP
rs144056447 1347 dbSNP
rs1219668681 1352 dbSNP
rs1272062870 1353 dbSNP
rs914180656 1358 dbSNP
rs1200281306 1360 dbSNP
rs756445514 1363 dbSNP
rs1467741127 1367 dbSNP
rs1196147926 1381 dbSNP
rs1247879711 1385 dbSNP
rs1010637163 1389 dbSNP
rs114172527 1394 dbSNP
rs554739336 1399 dbSNP
rs1173272261 1402 dbSNP
rs1032932951 1410 dbSNP
rs1303730411 1415 dbSNP
rs188742281 1422 dbSNP
rs1368533085 1428 dbSNP
rs889618290 1429 dbSNP
rs1048190620 1431 dbSNP
rs183553007 1440 dbSNP
rs1398518195 1441 dbSNP
rs557206265 1445 dbSNP
rs1036722761 1448 dbSNP
rs778958156 1455 dbSNP
rs538413533 1459 dbSNP
rs949065157 1463 dbSNP
rs917557301 1469 dbSNP
rs17166397 1472 dbSNP
rs897727906 1477 dbSNP
rs1014825536 1478 dbSNP
rs1175775971 1481 dbSNP
rs1006564065 1487 dbSNP
rs1452799771 1495 dbSNP
rs547723816 1496 dbSNP
rs867095053 1496 dbSNP
rs1263187632 1499 dbSNP
rs1056035793 1505 dbSNP
rs937102480 1512 dbSNP
rs1182939460 1518 dbSNP
rs546573028 1532 dbSNP
rs1475021791 1535 dbSNP
rs1045357502 1540 dbSNP
rs1195688935 1546 dbSNP
rs1406067480 1546 dbSNP
rs978913775 1546 dbSNP
rs1317709060 1548 dbSNP
rs534242182 1549 dbSNP
rs912914692 1553 dbSNP
rs1236115442 1557 dbSNP
rs913307909 1560 dbSNP
rs988378018 1561 dbSNP
rs879845211 1566 dbSNP
rs936923335 1568 dbSNP
rs566740696 1576 dbSNP
rs1167031116 1578 dbSNP
rs986739773 1579 dbSNP
rs1283192180 1582 dbSNP
rs1487599576 1585 dbSNP
rs1422092184 1587 dbSNP
rs761486254 1589 dbSNP
rs1219387358 1607 dbSNP
rs953430228 1611 dbSNP
rs748866294 1612 dbSNP
rs923373355 1614 dbSNP
rs1442256510 1615 dbSNP
rs779724908 1620 dbSNP
rs149526221 1626 dbSNP
rs1370489683 1627 dbSNP
rs1390694790 1630 dbSNP
rs1019570889 1632 dbSNP
rs1378510143 1652 dbSNP
rs962009489 1653 dbSNP
rs1314839221 1665 dbSNP
rs1433133003 1666 dbSNP
rs1006779543 1667 dbSNP
rs530158052 1670 dbSNP
rs1006096958 1672 dbSNP
rs1340714057 1675 dbSNP
rs776153572 1679 dbSNP
rs1159312270 1681 dbSNP
rs952093226 1683 dbSNP
rs1440941388 1695 dbSNP
rs562609089 1699 dbSNP
rs1001800245 1700 dbSNP
rs868040103 1707 dbSNP
rs907065712 1708 dbSNP
rs896942596 1714 dbSNP
rs1344920316 1719 dbSNP
rs550773491 1721 dbSNP
rs1257652312 1723 dbSNP
rs1037196993 1726 dbSNP
rs1045430850 1728 dbSNP
rs1258621574 1732 dbSNP
rs1009950756 1736 dbSNP
rs1484377149 1736 dbSNP
rs1443245360 1743 dbSNP
rs1013297639 1745 dbSNP
rs1277516756 1747 dbSNP
rs1054767722 1748 dbSNP
rs896159289 1748 dbSNP
rs891424217 1750 dbSNP
rs1464434405 1754 dbSNP
rs1054570815 1761 dbSNP
rs927514262 1764 dbSNP
rs532550549 1765 dbSNP
rs1328933817 1768 dbSNP
rs1378617006 1769 dbSNP
rs565618815 1785 dbSNP
rs1446972579 1787 dbSNP
rs936932207 1788 dbSNP
rs763895738 1789 dbSNP
rs1050598046 1790 dbSNP
rs932113679 1792 dbSNP
rs1231657228 1801 dbSNP
rs1227785671 1804 dbSNP
rs923446643 1822 dbSNP
rs1346206913 1828 dbSNP
rs569026116 1833 dbSNP
rs1355972769 1834 dbSNP
rs760377203 1835 dbSNP
rs1179357328 1839 dbSNP
rs1245962833 1843 dbSNP
rs113439613 1852 dbSNP
rs1431403653 1854 dbSNP
rs1200856575 1856 dbSNP
rs36069918 1856 dbSNP
rs1378111903 1862 dbSNP
rs167830 1864 dbSNP
rs539014725 1868 dbSNP
rs191714851 1892 dbSNP
rs965466308 1893 dbSNP
rs1292465047 1895 dbSNP
rs1465756314 1895 dbSNP
rs912565495 1895 dbSNP
rs951981609 1904 dbSNP
rs1304096953 1906 dbSNP
rs1034701367 1923 dbSNP
rs1383331023 1925 dbSNP
rs1218467970 1927 dbSNP
rs1001422025 1928 dbSNP
rs1276632430 1928 dbSNP
rs971172620 1942 dbSNP
rs1320278602 1945 dbSNP
rs989993644 1947 dbSNP
rs1024097511 1948 dbSNP
rs1264965556 1950 dbSNP
rs1009940800 1956 dbSNP
rs1211683879 1964 dbSNP
rs1268056001 1965 dbSNP
rs1475848333 1969 dbSNP
rs370696999 1970 dbSNP
rs995350090 1971 dbSNP
rs1425451221 1972 dbSNP
rs1477955514 1975 dbSNP
rs1163694629 1978 dbSNP
rs1347723669 1986 dbSNP
rs1459050384 1992 dbSNP
rs1293588246 1993 dbSNP
rs1420679739 2023 dbSNP
rs1296772828 2026 dbSNP
rs111650069 2031 dbSNP
rs1342720411 2031 dbSNP
rs202123093 2031 dbSNP
rs1247159717 2032 dbSNP
rs1266051924 2033 dbSNP
rs1487938773 2033 dbSNP
rs961506490 2034 dbSNP
rs1186374297 2041 dbSNP
rs891582639 2043 dbSNP
rs1265217338 2047 dbSNP
rs560887586 2050 dbSNP
rs1181061057 2051 dbSNP
rs1411250442 2056 dbSNP
rs1000294089 2059 dbSNP
rs1425122835 2065 dbSNP
rs750133764 2066 dbSNP
rs542610258 2067 dbSNP
rs1379112303 2072 dbSNP
rs774528441 2077 dbSNP
rs1157438041 2078 dbSNP
rs896225663 2086 dbSNP
rs1432015462 2092 dbSNP
rs1302623886 2096 dbSNP
rs1377264627 2097 dbSNP
rs1397939760 2102 dbSNP
rs1315845772 2107 dbSNP
rs187319816 2113 dbSNP
rs1238015303 2120 dbSNP
rs1281931312 2133 dbSNP
rs1001869386 2143 dbSNP
rs923392940 2146 dbSNP
rs1040602518 2147 dbSNP
rs138089697 2148 dbSNP
rs1207859047 2149 dbSNP
rs538870728 2152 dbSNP
rs771009902 2156 dbSNP
rs940746907 2157 dbSNP
rs755034632 2158 dbSNP
rs1231310113 2160 dbSNP
rs1378551982 2165 dbSNP
rs947622776 2167 dbSNP
rs1337683255 2172 dbSNP
rs1376434035 2173 dbSNP
rs1433235678 2174 dbSNP
rs907978814 2176 dbSNP
rs891975582 2182 dbSNP
rs533870040 2183 dbSNP
rs1320082335 2187 dbSNP
rs577750377 2190 dbSNP
rs371455874 2193 dbSNP
rs1204029950 2199 dbSNP
rs1313791422 2199 dbSNP
rs1257112506 2201 dbSNP
rs1179986284 2205 dbSNP
rs151148324 2205 dbSNP
rs1491406165 2206 dbSNP
rs1163415947 2207 dbSNP
rs1191173765 2208 dbSNP
rs1405274261 2213 dbSNP
rs1412524646 2214 dbSNP
rs567843864 2216 dbSNP
rs547952783 2217 dbSNP
rs1464203374 2218 dbSNP
rs1476220236 2219 dbSNP
rs927326605 2220 dbSNP
rs1355141368 2221 dbSNP
rs1435821691 2222 dbSNP
rs780963650 2224 dbSNP
rs979952436 2226 dbSNP
rs553269715 2229 dbSNP
rs1223956641 2230 dbSNP
rs562039915 2231 dbSNP
rs1315691423 2236 dbSNP
rs1200098921 2244 dbSNP
rs1273238670 2246 dbSNP
rs971328157 2247 dbSNP
rs1218733896 2257 dbSNP
rs1024086053 2259 dbSNP
rs988635466 2271 dbSNP
rs771137632 2274 dbSNP
rs1273853650 2275 dbSNP
rs1476976212 2283 dbSNP
rs961288491 2284 dbSNP
rs1015870639 2294 dbSNP
rs991986445 2295 dbSNP
rs1033153069 2300 dbSNP
rs1297145642 2301 dbSNP
rs150810665 2309 dbSNP
rs751985181 2313 dbSNP
rs1001923147 2314 dbSNP
rs1338092182 2315 dbSNP
rs567197516 2326 dbSNP
rs1270476368 2338 dbSNP
rs1355188274 2342 dbSNP
rs1226126822 2354 dbSNP
rs548194785 2363 dbSNP
rs1291319568 2365 dbSNP
rs889416588 2371 dbSNP
rs1021947763 2373 dbSNP
rs1027994092 2380 dbSNP
rs1012257065 2384 dbSNP
rs536205992 2385 dbSNP
rs1195776114 2386 dbSNP
rs1242971519 2395 dbSNP
rs892035714 2396 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL35
Disease MIMAT0015078
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020022. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucgggaggaccacCGACCGg 5'
                        | |||: 
Target 5' ---uuaagucauaaGAUGGUg 3'
 		1 - 18
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020022
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL35 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000284049.3 | 3UTR | UUAAGUCAUAAGAUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.927 0.01 -0.900 0.02 5 Click to see details
KIRP 0.947 0.03 1.000 0.5 4 Click to see details
KICH 0.83 0.04 0.900 0.02 5 Click to see details
UCEC -0.786 0.06 -0.700 0.09 5 Click to see details
CHOL -0.977 0.07 -0.500 0.33 3 Click to see details
BRCA 0.492 0.11 0.738 0.02 8 Click to see details
PRAD -0.78 0.11 -0.800 0.1 4 Click to see details
THCA 0.211 0.17 0.284 0.1 22 Click to see details
LIHC -0.163 0.23 0.003 0.49 23 Click to see details
KIRC -0.398 0.3 -0.400 0.3 4 Click to see details
HNSC 0.283 0.36 -0.200 0.4 4 Click to see details
STAD 0.036 0.46 0.079 0.41 10 Click to see details
STAD 0.036 0.46 0.079 0.41 10 Click to see details
STAD 0.036 0.46 0.079 0.41 10 Click to see details
72 hsa-miR-3194-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT443250 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT443284 ZC3H12A zinc finger CCCH-type containing 12A 2 2
MIRT461518 EMC7 ER membrane protein complex subunit 7 2 2
MIRT466738 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT467651 SLC7A1 solute carrier family 7 member 1 2 2
MIRT472998 MRPS23 mitochondrial ribosomal protein S23 2 4
MIRT477911 DUSP2 dual specificity phosphatase 2 2 2
MIRT480853 BLCAP bladder cancer associated protein 2 2
MIRT482890 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog 2 4
MIRT487295 SLC38A9 solute carrier family 38 member 9 2 2
MIRT488494 SFMBT2 Scm like with four mbt domains 2 2 4
MIRT489060 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT491209 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT491479 APC2 APC2, WNT signaling pathway regulator 2 8
MIRT492558 PRX periaxin 2 6
MIRT495499 SLC39A2 solute carrier family 39 member 2 2 2
MIRT496578 ZNF280D zinc finger protein 280D 2 2
MIRT496840 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT497840 CHD1 chromodomain helicase DNA binding protein 1 2 2
MIRT499396 PLCG2 phospholipase C gamma 2 2 7
MIRT503237 C16orf74 chromosome 16 open reading frame 74 2 4
MIRT512345 ZNF665 zinc finger protein 665 2 4
MIRT512527 ATCAY ATCAY, caytaxin 2 4
MIRT513160 PPIB peptidylprolyl isomerase B 2 2
MIRT514493 STOML1 stomatin like 1 2 2
MIRT517164 SLC28A1 solute carrier family 28 member 1 2 2
MIRT520463 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT524151 DIP2A disco interacting protein 2 homolog A 2 2
MIRT530324 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT533747 TMEM184B transmembrane protein 184B 2 2
MIRT534259 SLC12A7 solute carrier family 12 member 7 2 2
MIRT561273 ZDHHC18 zinc finger DHHC-type containing 18 2 2
MIRT569126 TMC5 transmembrane channel like 5 2 4
MIRT569937 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT570073 VPS8 VPS8, CORVET complex subunit 2 2
MIRT570636 KLF13 Kruppel like factor 13 2 2
MIRT571026 CENPP centromere protein P 2 2
MIRT573838 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT574899 Plcg2 phospholipase C, gamma 2 2 5
MIRT576070 Poteg POTE ankyrin domain family, member G 2 2
MIRT576753 Tmem127 transmembrane protein 127 2 2
MIRT611795 WNT9A Wnt family member 9A 2 2
MIRT616756 SVOP SV2 related protein 2 2
MIRT630965 NGDN neuroguidin 2 2
MIRT634555 LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2 2
MIRT638646 GK5 glycerol kinase 5 (putative) 2 2
MIRT639903 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT640529 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT644529 TMEM134 transmembrane protein 134 2 2
MIRT644887 C2orf50 chromosome 2 open reading frame 50 2 2
MIRT647729 CXCR2 C-X-C motif chemokine receptor 2 2 2
MIRT648086 FAM192A family with sequence similarity 192 member A 2 2
MIRT650808 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT660505 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT667193 NODAL nodal growth differentiation factor 2 2
MIRT685675 PSMB7 proteasome subunit beta 7 2 2
MIRT692710 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT693598 SLC39A1 solute carrier family 39 member 1 2 2
MIRT698059 TRIOBP TRIO and F-actin binding protein 2 2
MIRT698292 TMEM2 transmembrane protein 2 2 2
MIRT702353 KLHL26 kelch like family member 26 2 2
MIRT708623 NUDT18 nudix hydrolase 18 2 2
MIRT714289 KBTBD11 kelch repeat and BTB domain containing 11 2 2
MIRT714577 WDR41 WD repeat domain 41 2 2
MIRT716734 APOL6 apolipoprotein L6 2 2
MIRT718781 RAC3 Rac family small GTPase 3 2 2
MIRT720973 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT720986 TOM1 target of myb1 membrane trafficking protein 2 2
MIRT721391 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT722905 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT723205 ZNRF1 zinc and ring finger 1 2 2
MIRT725431 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3194 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-3194 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-3194 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-3194 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3194-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3194-5p Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3194-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3194-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-3194-5p Temozolomide 5394 NSC362856 approved resistant High Glioblastoma cell line (A172)
hsa-miR-3194-5p Estradiol 5757 NSC9895 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3194-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3194-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3194-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-3194-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-3194-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3194-5p Platinum 23939 resistant tissue
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3194-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3194-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-3194-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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