pre-miRNA Information
pre-miRNA hsa-mir-4747   
Genomic Coordinates chr19: 4932687 - 4932740
Description Homo sapiens miR-4747 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4747-5p
Sequence 1| AGGGAAGGAGGCUUGGUCUUAG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs560927363 4 dbSNP
rs1471226927 10 dbSNP
rs763137545 12 dbSNP
rs767337154 15 dbSNP
rs775298039 16 dbSNP
rs760472311 19 dbSNP
rs1207950315 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MYH14   
Synonyms DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin
Description myosin heavy chain 14
Transcript NM_001077186   
Other Transcripts NM_001145809 , NM_024729   
Expression
Putative miRNA Targets on MYH14
3'UTR of MYH14
(miRNA target sites are highlighted)
>MYH14|NM_001077186|3'UTR
   1 CCCTACCCTGTCCCCAGATGCACTAACAGATGGGGCCCAGCCCCCTTCCTCCCTGGACCCCACGGGCCCCTGTCCCAGGA
  81 ACCCCGCCCTCTGACTTCTTGCCCTTTGGAAATGGTGCAGCACTCTGGCATTTATCACCCCCACCTGGGTCCCCTGCAAC
 161 CTCCCATCAAAGGATGACCCCTAAACACAGAGGAGCGGGGCAGGCAGGGAGGCAATGACTGGAGCTACCTTGCTTGTTGG
 241 GGGACTGGGTACAGTTGGCAAGCTGTGTTTCCATCAGCTCCCTGTCCTCCTTTCTTCCCTCGTTATTGATCTATAGACAT
 321 TAGGAAGGGAGTGAGACGGCTCCTCCACCATCCTCAGCCAGTGCAACCCATTCCCTCTGCTTCTCTCTCTCTCTCTCTCT
 401 CTCCCTCCCTCTCCTTCCCTACCCTCTCACCATCTTTCTTGGCCTCTCTGAGGGTCTCTCTGTGCATCTTTTTAGGAATC
 481 TCGCTCTCACTCTCTACGTAGCCACTCTCCTTCCCCCATTTCTGCGTCCACCCCTGAACTCCTGAGCGACAGAAGCCCCA
 561 GGCCTCCACCAGCCTTGAACCCTTGCAAAGGGGCAGGACAAGGGGACCCCTCTCACTCCTGCTGCTGCCCATGCTCTGCC
 641 CTCCCTTCTGGTTGCTCTGAGGGTTCGGAGCTTCCCTCTGGGACTAAAGGAGTGTCCTTTACCCTCCCAGCCTCCAGGCT
 721 CTGGCAGAAATAAACTCCAACCCGACTGGACCATAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauucUGGUUCGGAGGAAGGGa 5'
               | | | :||||||||| 
Target 5' tacgtAGCCACTCTCCTTCCCc 3'
495 - 516 157.00 -20.90
2
miRNA  3' gaUUCUGGUUCGGAGGAAGGGa 5'
            ::|:|| |||| ||||||: 
Target 5' atGGGGCCCAGCCCCCTTCCTc 3'
30 - 51 156.00 -25.10
3
miRNA  3' gauucugguucGGAGGAAGGGa 5'
                     :||||||||| 
Target 5' ctctccctcccTCTCCTTCCCt 3'
399 - 420 151.00 -20.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
329953 65 ClinVar
329954 82 ClinVar
894015 87 ClinVar
329955 123 ClinVar
329956 143 ClinVar
329957 145 ClinVar
894417 156 ClinVar
329958 217 ClinVar
329959 244 ClinVar
329960 302 ClinVar
329961 303 ClinVar
329962 338 ClinVar
892974 369 ClinVar
329963 382 ClinVar
329964 382 ClinVar
329965 390 ClinVar
329966 401 ClinVar
892975 428 ClinVar
329967 475 ClinVar
329968 532 ClinVar
893199 605 ClinVar
329969 668 ClinVar
893200 739 ClinVar
COSM8554304 6 COSMIC
COSM7543717 9 COSMIC
COSM6213464 17 COSMIC
COSM8654188 30 COSMIC
COSM8647711 52 COSMIC
COSM8650368 85 COSMIC
COSN9851639 195 COSMIC
COSN1217619 201 COSMIC
COSN32071088 403 COSMIC
COSN1770451 467 COSMIC
COSN17037431 697 COSMIC
COSN16461556 744 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs768153073 1 dbSNP
rs1023277492 2 dbSNP
rs765102545 4 dbSNP
rs1340472326 5 dbSNP
rs1337597373 6 dbSNP
rs1259907744 7 dbSNP
rs769359886 9 dbSNP
rs774314722 11 dbSNP
rs766275446 12 dbSNP
rs1362081087 13 dbSNP
rs1217565196 14 dbSNP
rs1255770083 15 dbSNP
rs371235709 16 dbSNP
rs1438380083 17 dbSNP
rs1204133031 21 dbSNP
rs976576773 27 dbSNP
rs1277788027 33 dbSNP
rs754439562 36 dbSNP
rs1036378772 37 dbSNP
rs1173434296 39 dbSNP
rs1243881862 41 dbSNP
rs1206110385 45 dbSNP
rs1478194377 46 dbSNP
rs1466559533 47 dbSNP
rs1429239889 52 dbSNP
rs1193145624 56 dbSNP
rs780715963 57 dbSNP
rs1479217461 59 dbSNP
rs1030330334 60 dbSNP
rs1181440714 61 dbSNP
rs956269769 62 dbSNP
rs752312470 63 dbSNP
rs755809721 64 dbSNP
rs779130953 65 dbSNP
rs1345205563 68 dbSNP
rs1460782789 69 dbSNP
rs572631657 72 dbSNP
rs1275904041 76 dbSNP
rs772326631 82 dbSNP
rs780550154 86 dbSNP
rs772673014 87 dbSNP
rs1236495276 89 dbSNP
rs1169353101 96 dbSNP
rs546411129 101 dbSNP
rs1225332176 107 dbSNP
rs761718453 111 dbSNP
rs968806542 113 dbSNP
rs776901343 115 dbSNP
rs911210577 117 dbSNP
rs1490887418 122 dbSNP
rs12978083 123 dbSNP
rs766679106 125 dbSNP
rs1477252392 129 dbSNP
rs1416512577 134 dbSNP
rs1160781191 135 dbSNP
rs556063581 139 dbSNP
rs1057321857 142 dbSNP
rs770209944 143 dbSNP
rs773312540 145 dbSNP
rs1040963691 150 dbSNP
rs918532693 156 dbSNP
rs929791430 157 dbSNP
rs929654417 171 dbSNP
rs1235649838 174 dbSNP
rs1048705015 176 dbSNP
rs1465796826 180 dbSNP
rs1048111587 191 dbSNP
rs576031713 198 dbSNP
rs1210935131 201 dbSNP
rs1011966126 202 dbSNP
rs888002456 209 dbSNP
rs627491 217 dbSNP
rs1244586974 219 dbSNP
rs1454127431 226 dbSNP
rs1039165394 242 dbSNP
rs561898739 244 dbSNP
rs1360270680 250 dbSNP
rs1318020535 254 dbSNP
rs1418255216 257 dbSNP
rs1362626543 262 dbSNP
rs1003661286 269 dbSNP
rs1035941349 274 dbSNP
rs1387812161 282 dbSNP
rs529409417 302 dbSNP
rs544178350 303 dbSNP
rs1391962876 305 dbSNP
rs1473064946 307 dbSNP
rs1386011754 320 dbSNP
rs1241450789 334 dbSNP
rs753307318 338 dbSNP
rs1333103900 339 dbSNP
rs186982330 354 dbSNP
rs377444835 357 dbSNP
rs1021591833 359 dbSNP
rs968571618 361 dbSNP
rs1291342075 366 dbSNP
rs1287849467 367 dbSNP
rs1380439241 368 dbSNP
rs74582015 369 dbSNP
rs927144911 374 dbSNP
rs79499376 376 dbSNP
rs1187786369 382 dbSNP
rs1418693773 382 dbSNP
rs376379600 382 dbSNP
rs538810577 382 dbSNP
rs761762835 382 dbSNP
rs886054594 382 dbSNP
rs886054595 382 dbSNP
rs918310533 382 dbSNP
rs149455351 390 dbSNP
rs570759880 396 dbSNP
rs1271866256 398 dbSNP
rs1488323521 399 dbSNP
rs1248095191 401 dbSNP
rs886054596 401 dbSNP
rs911348257 403 dbSNP
rs537716543 406 dbSNP
rs1217391761 408 dbSNP
rs1320654768 410 dbSNP
rs1267600832 416 dbSNP
rs1386568472 419 dbSNP
rs1453041387 427 dbSNP
rs190088995 428 dbSNP
rs1410651183 429 dbSNP
rs1437280496 433 dbSNP
rs1053991 439 dbSNP
rs567917288 447 dbSNP
rs1472646722 454 dbSNP
rs1354054473 461 dbSNP
rs1168418686 471 dbSNP
rs886054597 475 dbSNP
rs1161198188 477 dbSNP
rs918471524 483 dbSNP
rs1039728672 484 dbSNP
rs1431241842 485 dbSNP
rs1426813497 488 dbSNP
rs1191477068 490 dbSNP
rs900656819 491 dbSNP
rs929902352 492 dbSNP
rs764240575 498 dbSNP
rs909706020 499 dbSNP
rs1393102210 510 dbSNP
rs947914355 518 dbSNP
rs1053995 523 dbSNP
rs1303643165 526 dbSNP
rs1044791859 527 dbSNP
rs906328498 530 dbSNP
rs886054598 532 dbSNP
rs1003178012 543 dbSNP
rs1351142263 545 dbSNP
rs1052535104 548 dbSNP
rs1291919454 549 dbSNP
rs535549417 553 dbSNP
rs1369788805 557 dbSNP
rs1321709858 561 dbSNP
rs753971693 565 dbSNP
rs1378102583 567 dbSNP
rs1021539838 573 dbSNP
rs1439838976 578 dbSNP
rs968727650 580 dbSNP
rs1200431071 583 dbSNP
rs967091412 594 dbSNP
rs892017404 596 dbSNP
rs1034706318 599 dbSNP
rs1010890570 606 dbSNP
rs1202529988 607 dbSNP
rs960005098 607 dbSNP
rs1250619367 610 dbSNP
rs993043811 610 dbSNP
rs1242388968 611 dbSNP
rs1483062809 627 dbSNP
rs866924363 644 dbSNP
rs1377828288 661 dbSNP
rs1311878870 664 dbSNP
rs553952601 665 dbSNP
rs572169961 667 dbSNP
rs886054599 668 dbSNP
rs1253992561 673 dbSNP
rs1418881973 674 dbSNP
rs1423211481 694 dbSNP
rs1160160666 700 dbSNP
rs1165182964 710 dbSNP
rs1419744731 714 dbSNP
rs1384125578 720 dbSNP
rs1054011 722 dbSNP
rs1369928858 723 dbSNP
rs757578666 726 dbSNP
rs1422537513 736 dbSNP
rs540069517 739 dbSNP
rs567968417 744 dbSNP
rs558366138 745 dbSNP
rs1488199134 751 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gauucugguucGGAGGAAGGGa 5'
                     :|||| |||| 
Target 5' cucucucucucUCUCCCUCCCu 3'
9 - 30
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gauucugGUUCGGAGGAAGGGa 5'
                 | | :||||||||| 
Target 5' -------CCACUCUCCUUCCCc 3'
1 - 15
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760618. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3_B PAR-CLIP data was present in SRX1760630. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_A PAR-CLIP data was present in SRX1760616. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000601313.1 | 3UTR | UUCUCUCUCUCUCUCUCUCUCUCCCUCCCUCUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
215 hsa-miR-4747-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061689 BTG2 BTG anti-proliferation factor 2 2 2
MIRT062834 BCL7A BCL tumor suppressor 7A 2 2
MIRT079371 CCDC137 coiled-coil domain containing 137 2 2
MIRT081190 MIDN midnolin 2 4
MIRT081724 ZNF507 zinc finger protein 507 2 2
MIRT110565 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT133724 SKI SKI proto-oncogene 2 4
MIRT146689 MINK1 misshapen like kinase 1 2 2
MIRT150676 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159196 NRBP1 nuclear receptor binding protein 1 2 2
MIRT180865 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT190659 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196111 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT232390 SP1 Sp1 transcription factor 2 2
MIRT331070 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT338632 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT407441 CTDSP1 CTD small phosphatase 1 2 2
MIRT444276 NKX6-1 NK6 homeobox 1 2 2
MIRT444834 PDE6D phosphodiesterase 6D 2 2
MIRT445452 EXT1 exostosin glycosyltransferase 1 2 2
MIRT445644 NPY4R neuropeptide Y receptor Y4 2 2
MIRT446157 RPL12 ribosomal protein L12 2 2
MIRT446608 HIP1 huntingtin interacting protein 1 2 2
MIRT447108 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT449314 MRO maestro 2 2
MIRT450305 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451245 ZNF444 zinc finger protein 444 2 2
MIRT451714 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451908 ILK integrin linked kinase 2 2
MIRT452183 KIAA1456 KIAA1456 2 2
MIRT452610 REPIN1 replication initiator 1 2 2
MIRT453422 GLG1 golgi glycoprotein 1 2 2
MIRT454006 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455072 ARHGAP39 Rho GTPase activating protein 39 2 2
MIRT455319 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT455357 KDM5C lysine demethylase 5C 2 2
MIRT455589 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455711 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT455860 TMEM254 transmembrane protein 254 2 2
MIRT455919 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT455946 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456935 LRP10 LDL receptor related protein 10 2 2
MIRT457223 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT457431 NOL10 nucleolar protein 10 2 2
MIRT457470 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457907 ZNF212 zinc finger protein 212 2 2
MIRT458046 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458073 RNLS renalase, FAD dependent amine oxidase 2 2
MIRT458234 NXPH3 neurexophilin 3 2 2
MIRT458307 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458378 ITM2C integral membrane protein 2C 2 2
MIRT458967 ZNF436 zinc finger protein 436 2 2
MIRT459099 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459446 TMEM37 transmembrane protein 37 2 2
MIRT459671 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460727 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT460744 SRP14 signal recognition particle 14 2 2
MIRT461531 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461752 DDX11 DEAD/H-box helicase 11 2 2
MIRT461837 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT462019 RIF1 replication timing regulatory factor 1 2 2
MIRT462631 PHF5A PHD finger protein 5A 2 2
MIRT462772 ZNF8 zinc finger protein 8 2 2
MIRT463032 ZNF689 zinc finger protein 689 2 2
MIRT463886 WNT7B Wnt family member 7B 2 2
MIRT463995 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464371 URM1 ubiquitin related modifier 1 2 2
MIRT465342 TPM3 tropomyosin 3 2 4
MIRT465515 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465602 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT465697 TNPO2 transportin 2 2 10
MIRT466988 SSRP1 structure specific recognition protein 1 2 4
MIRT467630 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468132 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468322 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468502 SESN2 sestrin 2 2 2
MIRT468881 RREB1 ras responsive element binding protein 1 2 2
MIRT469322 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469562 RARA retinoic acid receptor alpha 2 2
MIRT469898 PTRF caveolae associated protein 1 2 2
MIRT470045 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470068 PTGES2 prostaglandin E synthase 2 2 2
MIRT470238 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470390 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470500 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470689 POLR2D RNA polymerase II subunit D 2 2
MIRT470704 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471083 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472482 NACC2 NACC family member 2 2 2
MIRT473583 MAT2A methionine adenosyltransferase 2A 2 2
MIRT474554 KLHDC3 kelch domain containing 3 2 2
MIRT474651 KLF13 Kruppel like factor 13 2 2
MIRT474843 KHSRP KH-type splicing regulatory protein 2 2
MIRT474934 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475573 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT476045 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476080 GRB2 growth factor receptor bound protein 2 2 2
MIRT476440 GBA2 glucosylceramidase beta 2 2 2
MIRT476764 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT478785 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479287 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT479505 CDH6 cadherin 6 2 2
MIRT479732 CCND1 cyclin D1 2 6
MIRT480352 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480407 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480859 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT481445 ARRB2 arrestin beta 2 2 2
MIRT481732 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT481824 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482566 ABHD2 abhydrolase domain containing 2 2 2
MIRT482607 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483144 SYCE1L synaptonemal complex central element protein 1 like 2 2
MIRT483214 APOA1 apolipoprotein A1 2 6
MIRT483878 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483917 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483939 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484420 SNX19 sorting nexin 19 2 2
MIRT484489 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484612 SIX3 SIX homeobox 3 2 6
MIRT484705 RNF11 ring finger protein 11 2 2
MIRT485107 SHISA6 shisa family member 6 2 2
MIRT485354 MYO1C myosin IC 2 4
MIRT485609 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT487311 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487417 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487695 CDK14 cyclin dependent kinase 14 2 2
MIRT487791 GPR20 G protein-coupled receptor 20 2 4
MIRT488042 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488058 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488237 DNLZ DNL-type zinc finger 2 4
MIRT488764 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489401 TUBB2A tubulin beta 2A class IIa 2 2
MIRT489777 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490099 FN3K fructosamine 3 kinase 2 2
MIRT490290 ISL2 ISL LIM homeobox 2 2 2
MIRT490378 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491329 GFER growth factor, augmenter of liver regeneration 2 2
MIRT491435 MSX2 msh homeobox 2 2 2
MIRT491769 ZNF385A zinc finger protein 385A 2 2
MIRT491922 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT491983 UNK unkempt family zinc finger 2 2
MIRT492228 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492404 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT492767 PDGFB platelet derived growth factor subunit B 2 2
MIRT492966 NCS1 neuronal calcium sensor 1 2 2
MIRT493295 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493650 HDLBP high density lipoprotein binding protein 2 2
MIRT493913 FAM127B retrotransposon Gag like 8A 2 4
MIRT495601 NKX2-5 NK2 homeobox 5 2 2
MIRT496875 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT498514 MYH14 myosin heavy chain 14 2 2
MIRT499178 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT502143 KIF5B kinesin family member 5B 2 8
MIRT502692 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT508460 HOXB6 homeobox B6 2 4
MIRT510430 ZNF207 zinc finger protein 207 2 6
MIRT511837 GPATCH8 G-patch domain containing 8 2 4
MIRT512368 CPM carboxypeptidase M 2 2
MIRT512506 BTBD19 BTB domain containing 19 2 2
MIRT513065 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513267 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 2 4
MIRT513575 EVX1 even-skipped homeobox 1 2 2
MIRT515051 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515790 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT521657 PRKD3 protein kinase D3 2 2
MIRT522679 LUZP1 leucine zipper protein 1 2 6
MIRT528845 RAB32 RAB32, member RAS oncogene family 2 2
MIRT533569 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT543738 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544295 TSPYL1 TSPY like 1 2 2
MIRT544857 MYH2 myosin heavy chain 2 2 4
MIRT557323 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT560522 TMEM98 transmembrane protein 98 2 2
MIRT561565 SLC6A9 solute carrier family 6 member 9 2 2
MIRT562374 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT565780 SEMA6D semaphorin 6D 2 2
MIRT569548 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569944 PRRT2 proline rich transmembrane protein 2 2 2
MIRT570016 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572163 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT572322 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573495 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574139 MARVELD1 MARVEL domain containing 1 2 2
MIRT609449 CCDC149 coiled-coil domain containing 149 2 2
MIRT610619 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT623355 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT629854 ACOX1 acyl-CoA oxidase 1 2 2
MIRT630516 CDC73 cell division cycle 73 2 2
MIRT632535 PSMB2 proteasome subunit beta 2 2 2
MIRT633975 SLC35E2 solute carrier family 35 member E2 2 2
MIRT636408 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT641722 LTBR lymphotoxin beta receptor 2 2
MIRT642661 RGS6 regulator of G protein signaling 6 2 2
MIRT649649 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT650367 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT651355 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT664840 HUS1 HUS1 checkpoint clamp component 2 2
MIRT667322 MYH9 myosin heavy chain 9 2 2
MIRT670680 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT674922 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT675919 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT676493 GJD3 gap junction protein delta 3 2 2
MIRT680162 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT688008 GSN gelsolin 2 2
MIRT688997 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT700337 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT701344 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703519 FKBP15 FK506 binding protein 15 2 2
MIRT703901 EPT1 selenoprotein I 2 2
MIRT705565 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 2 2
MIRT709709 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 2 2
MIRT713108 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT718426 ZNF85 zinc finger protein 85 2 2
MIRT719236 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719326 STAC SH3 and cysteine rich domain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4747 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4747-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4747-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4747-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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