miRTarBase - #MIRT498772


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pre-miRNA Information
pre-miRNA hsa-mir-106a   
Genomic Coordinates chrX: 134170198 - 134170278
Description Homo sapiens miR-106a stem-loop
Comment This miRNA was not cloned in reference .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-106a-3p
Sequence 50| CUGCAAUGUAAGCACUUCUUAC |71
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs927823355 6 dbSNP
rs1448271699 8 dbSNP
rs1477844174 12 dbSNP
rs1358970494 18 dbSNP
rs781747706 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BN3X2A miR-106a Predictive Biomarker (PRD) Clinical/Experimental Data Expression Decrease Tumor tissue Quantitative real-time PCR
Gene Information
Gene Symbol PARP15   
Synonyms ARTD7, BAL3, pART7
Description poly(ADP-ribose) polymerase family member 15
Transcript NM_001113523   
Other Transcripts NM_152615   
Expression
Putative miRNA Targets on PARP15
3'UTR of PARP15
(miRNA target sites are highlighted)		 
>PARP15|NM_001113523|3'UTR
   1 AAATATTTTTATCATCAAAGAGATGATTTAAGTCATCTGTAAGAACAACATGCAATCTTTGTCTTTGCTTCTGGCCTGTG
  81 TAAGCAGATGAAAGTTTCCCTTTTAGGTGCCAAAATGCTGAAAATTACCTTTTTAAAGTGCTCTATTGCTGCGATTTGTA
 161 GCATACCTTTTTTTCTCAGCAAATTGATGGGTGGAAGCTGAGAAATGTATGGTAAATGTCACAGAGCTACAACCATTCAC
 241 AGACACCAAATCTCTAGGAGAATAAAAAGCACATTATTCTTTTTCTATCAGAAAAAAACAAGATGCATCACCTTAAAACC
 321 AAGATGACATTGTTCTTCTTGGAACATGTTAAGACATCGAATGGTGGCGGGTTAAACTGTACTGCTTAAGTGGAGCGGCT
 401 ACCGTTATGCATCTATCACAGTTGGGGATTTTGCCTTATTAAGGAAAACTTGTCAATAGTTCAGCTGAAATGACTGAATC
 481 ACAGAATATTAACTCTGTTATGGAACAAATCATAACAGATTTTACCTGTTTACATTTCAGGTAAAAATGTATCGCATTGT
 561 TATCTAATATTAAAAAATTACCCCCAATTTTAGTGACTTAATCCCACACAGTCTTTATGGGTCAGGAATTCAGGCATGGC
 641 TTACCTGGATCATTCTGCTAGGGTCTCTCTGAAGTTACAGACAAGATGTCAGGGGATGTGGTCGTTTGAAGGCTTGTCTG
 721 GGCTGGAGGTCTATTTCCAAGGTGAATCACTCACATACCTGGCACGTTTCTGTCAGGTATTGGCAGTCCTCAGTTCCTCT
 801 CCTCTCAGGCCTCTCCACAGGCTGCTTGAGTGTCCTCATGACACAACAGTTGGCTTACTCCAGAGTGAGCAACTCAAGAG
 881 AGAGCAAGGCAGAAGCTACCAAATCTTTATGTTTGAAGTCATGCACCATCTTTTCCACGAGTATCCTGTTGATTATTTTG
 961 ATCAGCTTGTTCAGTCTGGGAGGGAATTGCACAAGGGCATGAATACTCCACTGGCAAGGATCATTGGGGGCCATCTTGGA
1041 AGCTGTGTGAATGAGCAAATGAATGCACAGATAGAATATTAGCAGTGACAATGATGCTAGAGGTCACCTACCCCACTGTC
1121 CTCTTGTCCTTCTCCCCCAACCCTCCCCTGCTCCCAGGCAAGAAGCCCTCTAGCCTCTGCTTGATCACTTTCAGCACTCA
1201 ACATCTTCAGGGAACCTATTCCGCCGTGGGACAGTGTTAATTAGTGGAAAACTCTTTTTCAAAAGTTGAAATCAGTTCCT
1281 CTGTGTCTATTACCTGCTGATCACTGTCCAGACTTCTGGAGGACACAGAGCAAGTTTTATTCCTCTTACTGATGGTAGCC
1361 TTTCAGATCCATCCCTTCCCTCCAGTATATTAGAGTTACGTAAATTCTTAAAATGCTTAGCAGCTCATTTATCCTGAAGC
1441 ATCACTTTTGAAGAGTTACAGACATTTAAGAAGTATTTACATTATCATAAATAAATTACATGCGCATTTAAAGAGAACAG
1521 AAAAGTATAAAGAAAAATAACTCACCAAACTCACTCATAATTCCAGCACTAAGGGAAAACCACTGCCAATTTCTCATGTC
1601 TCCCTTCCAGTTTCTTCTCTGTCCAAATTCAACAAAGTCAAAATCACATTTTGTTCTGTCACAAATCATATAATATTATT
1681 TCTACCATTTTTCTTTTTTTAATCTTTTTTTATTATACTTTAAGTTTTAGGGTACATGTGCACAATGTGCAGTTTAGTTA
1761 CATATGTAAACATGTGCCATGTTGGTGTGCTGCACCCAGTAACTCATCATTTAGCATTAGGTATATCTCCAAATGCTATC
1841 CCTCTCCCCTCTCCCCACCCCACAACAGGCCCCGGTGTGTGATGTTCCCCTTCCTGTGTCCATGTGTTCTCATTGTTCAA
1921 TTCCCACCTGTGAGTGAGAACATGTGGTGTTTGGTTTTTTGTCCTTGCGATAGTTTGCTGAGAATGATGGTTTCCAGCTT
2001 CATCCATGTCCCTACAAAGGACATGAACTCATCATTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTT
2081 TCTTAATCCAGTCTATCATTGTTGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCCGCAATAAACATA
2161 CGTGTGCATGTGTCTTTACAGCAGCATGATTTATAATCCTTTGGGTATATACCCAGTAATGGGATTGCTGGGTCAAATGG
2241 TATTTCTAGTTCTAGATCCCCGAGGAATCGCCACACTGACTTCCACAATGGTTGAACTAGTTTACAGTCCCACCAACAGT
2321 GTAAAAGTGTTCCTATTTCTCCACATCCTCTCCAGCACCTGTTGCTTCCTAACTTTTTAATGATTGCCATTCTAACGGGT
2401 GTGGGATGGTATCTCATTGTTGTTTTGATTTGCATTTCTCTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTTTTTT
2481 GGCTGCATAAATGTCTTCTTTTGAGAAGTGTCCGTTCATATCCTTTGCCCACTTTTTGATGGGGTTCTTTGTTTTTTTCT
2561 TGTATATTTGTTTGAGTTCATTGTAGATTCTGGATATTAGCCCTTTGTCAGATGAGTAGATTGCAAAAATTTTCTCCCAT
2641 TCTGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGTTGTACAGAAGCTCTTTAGTTTAATTAGATCCCATATTTC
2721 TACCATTTTTCATTAAACATTACAAGTTGTTCTCTTGTGTTCTTATTTTTTCTGTAAACATAATTTTAATGGCAGAGATA
2801 TTCTGCTTTATATCTTTCCCTATTTTATGTATATAGAATTATAAAGTTTTTAAAAATGTAATCATCATTATTTATAGTTT
2881 AATAATCAGTTTCATCTTGCAGTGTATCATTTTCCTCGTCATTAAATATTTTACGTATCATTTTTAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cauucuucACGAAUGUAACGUc 5'
                  ||:||||||| || 
Target 5' attttaccTGTTTACATTTCAg 3'
 519 - 540 134.00 -12.50
2 
miRNA  3' cauUCUUCACGAAU----GUAACGUc 5'
             | |  ||:||:    |||||:| 
Target 5' tgtATATTTGTTTGAGTTCATTGTAg 3'
 2561 - 2586 133.00 -10.80
3 
miRNA  3' caUUCUUCACGAAUGUAAcguc 5'
            ||||||| :|||||||    
Target 5' ttAAGAAGTATTTACATTatca 3'
 1466 - 1487 128.00 -15.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30119475 11 COSMIC
COSN30454679 11 COSMIC
COSN30184164 25 COSMIC
COSN30482059 26 COSMIC
COSN5145036 35 COSMIC
COSN31566097 42 COSMIC
COSN31575025 44 COSMIC
COSN31575344 58 COSMIC
COSN31573808 114 COSMIC
COSN1911473 180 COSMIC
COSN9735767 223 COSMIC
COSN17181638 232 COSMIC
COSN9234475 718 COSMIC
COSN20606552 836 COSMIC
COSN21453672 932 COSMIC
COSN14869166 1226 COSMIC
COSN14753805 1254 COSMIC
COSN28451765 1272 COSMIC
COSN7815073 1387 COSMIC
COSN9234476 1396 COSMIC
COSN14795148 1400 COSMIC
COSN6571248 1505 COSMIC
COSN14742331 2686 COSMIC
COSN25392202 2840 COSMIC
rs78411303 1505 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1223891164 3 dbSNP
rs1412233116 6 dbSNP
rs768143154 7 dbSNP
rs1373463256 12 dbSNP
rs774341559 13 dbSNP
rs376034815 15 dbSNP
rs1264073731 17 dbSNP
rs1309929015 19 dbSNP
rs200442595 23 dbSNP
rs1167364253 25 dbSNP
rs761745098 26 dbSNP
rs1317865839 28 dbSNP
rs1273657532 35 dbSNP
rs1339738913 38 dbSNP
rs1206566778 39 dbSNP
rs767386265 40 dbSNP
rs1482870158 42 dbSNP
rs773014660 47 dbSNP
rs1245034459 52 dbSNP
rs760354980 53 dbSNP
rs894647727 58 dbSNP
rs141095508 62 dbSNP
rs566409784 75 dbSNP
rs1349954977 78 dbSNP
rs1024526313 99 dbSNP
rs1405504670 102 dbSNP
rs534884424 106 dbSNP
rs999049757 119 dbSNP
rs947005514 122 dbSNP
rs750890029 128 dbSNP
rs1345554750 130 dbSNP
rs1160947277 141 dbSNP
rs868627609 142 dbSNP
rs113058777 146 dbSNP
rs56286949 148 dbSNP
rs939068916 149 dbSNP
rs1206891415 153 dbSNP
rs187373950 154 dbSNP
rs1191120623 168 dbSNP
rs910258474 168 dbSNP
rs1486404777 174 dbSNP
rs1270333942 185 dbSNP
rs1207093177 190 dbSNP
rs528920972 208 dbSNP
rs747363757 213 dbSNP
rs1187983201 227 dbSNP
rs1263960464 234 dbSNP
rs1235558728 236 dbSNP
rs1329410397 244 dbSNP
rs1299180306 246 dbSNP
rs975887662 261 dbSNP
rs1362411522 269 dbSNP
rs1003878985 270 dbSNP
rs1432478461 271 dbSNP
rs1387516268 273 dbSNP
rs1176672130 275 dbSNP
rs775695411 280 dbSNP
rs556890925 285 dbSNP
rs370336625 290 dbSNP
rs1467195226 292 dbSNP
rs1375371078 294 dbSNP
rs1429585496 299 dbSNP
rs375253307 299 dbSNP
rs898400091 304 dbSNP
rs1049002469 306 dbSNP
rs1464701773 308 dbSNP
rs1455713262 310 dbSNP
rs1202379638 312 dbSNP
rs1342981722 315 dbSNP
rs1255422439 323 dbSNP
rs1174397716 325 dbSNP
rs996788938 326 dbSNP
rs1454617405 330 dbSNP
rs1299706309 336 dbSNP
rs755759399 347 dbSNP
rs941321570 348 dbSNP
rs1364189657 351 dbSNP
rs1055892583 355 dbSNP
rs955249693 357 dbSNP
rs1399472344 359 dbSNP
rs987928379 360 dbSNP
rs1019034834 369 dbSNP
rs541689537 370 dbSNP
rs555229260 371 dbSNP
rs1372733110 380 dbSNP
rs369726193 382 dbSNP
rs1217057033 383 dbSNP
rs1255591647 385 dbSNP
rs1300152348 389 dbSNP
rs988094820 391 dbSNP
rs144923807 395 dbSNP
rs374340398 397 dbSNP
rs866668868 398 dbSNP
rs981065237 400 dbSNP
rs148085969 403 dbSNP
rs939537131 404 dbSNP
rs1057073407 405 dbSNP
rs886852055 416 dbSNP
rs1208217721 428 dbSNP
rs1007606775 439 dbSNP
rs1253625852 442 dbSNP
rs1338386788 449 dbSNP
rs939778573 451 dbSNP
rs1038022723 453 dbSNP
rs1470001217 456 dbSNP
rs746407217 457 dbSNP
rs1189753361 461 dbSNP
rs1266937079 475 dbSNP
rs975814066 480 dbSNP
rs1240897038 491 dbSNP
rs1366620188 493 dbSNP
rs1165318112 496 dbSNP
rs1472004188 498 dbSNP
rs1368155637 502 dbSNP
rs898180755 503 dbSNP
rs777338283 523 dbSNP
rs1161704191 539 dbSNP
rs1410442856 552 dbSNP
rs1202971832 554 dbSNP
rs141841307 555 dbSNP
rs575270955 557 dbSNP
rs890917020 560 dbSNP
rs1283293401 562 dbSNP
rs984710872 563 dbSNP
rs73856214 567 dbSNP
rs1285867978 570 dbSNP
rs1409775710 573 dbSNP
rs1332231437 581 dbSNP
rs1326074322 582 dbSNP
rs1404020242 583 dbSNP
rs1160201242 597 dbSNP
rs566329306 598 dbSNP
rs1031957263 604 dbSNP
rs1181611937 608 dbSNP
rs956775076 610 dbSNP
rs1480786736 614 dbSNP
rs1247282111 626 dbSNP
rs1200895290 629 dbSNP
rs991875917 633 dbSNP
rs1288796821 645 dbSNP
rs150208252 646 dbSNP
rs988209624 647 dbSNP
rs543880517 648 dbSNP
rs1286179568 649 dbSNP
rs1227293279 651 dbSNP
rs528878953 656 dbSNP
rs1045789305 663 dbSNP
rs1277178010 665 dbSNP
rs1328393948 666 dbSNP
rs1434868427 672 dbSNP
rs968028814 677 dbSNP
rs1233757710 679 dbSNP
rs1437696514 683 dbSNP
rs903363024 684 dbSNP
rs981390649 688 dbSNP
rs1323650107 696 dbSNP
rs1415164968 697 dbSNP
rs549027544 702 dbSNP
rs926893252 704 dbSNP
rs773855544 705 dbSNP
rs1174248720 708 dbSNP
rs138827758 713 dbSNP
rs1481053085 714 dbSNP
rs1054725496 718 dbSNP
rs893353155 721 dbSNP
rs1245885511 730 dbSNP
rs1179325317 734 dbSNP
rs1207698639 745 dbSNP
rs1442510922 747 dbSNP
rs992324422 753 dbSNP
rs544173809 755 dbSNP
rs908731765 756 dbSNP
rs1218001352 758 dbSNP
rs528822136 766 dbSNP
rs1007790222 775 dbSNP
rs1038137284 780 dbSNP
rs1363451992 786 dbSNP
rs2650954 790 dbSNP
rs1448944448 795 dbSNP
rs772023298 800 dbSNP
rs1332223261 802 dbSNP
rs997307460 805 dbSNP
rs932338652 816 dbSNP
rs1169138056 824 dbSNP
rs1403151543 826 dbSNP
rs950539913 840 dbSNP
rs1388032595 841 dbSNP
rs1049902643 849 dbSNP
rs1163406769 859 dbSNP
rs891039930 864 dbSNP
rs1238820002 869 dbSNP
rs1016200983 876 dbSNP
rs1207458907 876 dbSNP
rs1276042669 879 dbSNP
rs959576514 892 dbSNP
rs143141092 911 dbSNP
rs990740210 922 dbSNP
rs1297269835 927 dbSNP
rs537123217 929 dbSNP
rs1008591096 939 dbSNP
rs1229126201 940 dbSNP
rs1381683614 949 dbSNP
rs1052939016 958 dbSNP
rs891649990 959 dbSNP
rs1009578708 961 dbSNP
rs1022338801 974 dbSNP
rs150072758 982 dbSNP
rs1371235010 983 dbSNP
rs1308578331 994 dbSNP
rs1431482086 998 dbSNP
rs1368510827 1000 dbSNP
rs551284352 1001 dbSNP
rs1424141735 1002 dbSNP
rs552725704 1012 dbSNP
rs1179736958 1018 dbSNP
rs981498344 1023 dbSNP
rs1251824136 1024 dbSNP
rs968141618 1025 dbSNP
rs1482331095 1031 dbSNP
rs1251225187 1035 dbSNP
rs72962341 1037 dbSNP
rs1226703342 1041 dbSNP
rs1289156951 1043 dbSNP
rs934846899 1044 dbSNP
rs1034124424 1045 dbSNP
rs567457877 1048 dbSNP
rs1351193782 1051 dbSNP
rs1290250198 1055 dbSNP
rs1411613694 1058 dbSNP
rs1207635573 1060 dbSNP
rs1272748570 1072 dbSNP
rs375955096 1075 dbSNP
rs35782160 1080 dbSNP
rs1162262267 1082 dbSNP
rs568837950 1086 dbSNP
rs147506450 1092 dbSNP
rs1183777262 1100 dbSNP
rs961547158 1103 dbSNP
rs1472074651 1104 dbSNP
rs764361088 1109 dbSNP
rs1471307362 1112 dbSNP
rs776781879 1114 dbSNP
rs1419530651 1126 dbSNP
rs76776363 1131 dbSNP
rs567293908 1135 dbSNP
rs1369520918 1147 dbSNP
rs541318829 1151 dbSNP
rs997151988 1154 dbSNP
rs367977229 1157 dbSNP
rs1270212246 1160 dbSNP
rs1314433778 1161 dbSNP
rs1357388386 1162 dbSNP
rs557637642 1167 dbSNP
rs140126686 1169 dbSNP
rs912238215 1175 dbSNP
rs1270686604 1177 dbSNP
rs1306214271 1182 dbSNP
rs943947348 1188 dbSNP
rs1052980020 1194 dbSNP
rs1005953040 1197 dbSNP
rs891590930 1203 dbSNP
rs543676171 1204 dbSNP
rs1388975903 1215 dbSNP
rs563349926 1216 dbSNP
rs1042904582 1223 dbSNP
rs1362654340 1224 dbSNP
rs2668332 1226 dbSNP
rs1002721102 1227 dbSNP
rs1441203733 1228 dbSNP
rs1423539016 1233 dbSNP
rs1210100695 1234 dbSNP
rs971382169 1243 dbSNP
rs981382197 1246 dbSNP
rs386665276 1252 dbSNP
rs879358039 1252 dbSNP
rs542635190 1253 dbSNP
rs2668334 1254 dbSNP
rs1485585294 1259 dbSNP
rs990241236 1260 dbSNP
rs1233907534 1262 dbSNP
rs1013801173 1266 dbSNP
rs1454414872 1268 dbSNP
rs34977190 1269 dbSNP
rs914766635 1276 dbSNP
rs1422874427 1279 dbSNP
rs1039702714 1282 dbSNP
rs767031217 1290 dbSNP
rs1383662003 1291 dbSNP
rs112661332 1302 dbSNP
rs923490768 1324 dbSNP
rs1376499061 1326 dbSNP
rs961664005 1329 dbSNP
rs1173544602 1331 dbSNP
rs765851081 1345 dbSNP
rs932992403 1349 dbSNP
rs751928394 1350 dbSNP
rs1346873579 1351 dbSNP
rs1428090618 1355 dbSNP
rs1257094257 1367 dbSNP
rs528733411 1381 dbSNP
rs886093006 1394 dbSNP
rs1318580220 1398 dbSNP
rs2668335 1400 dbSNP
rs191773052 1401 dbSNP
rs1324995378 1411 dbSNP
rs1276811169 1419 dbSNP
rs1343392092 1428 dbSNP
rs1218972695 1432 dbSNP
rs1325542484 1433 dbSNP
rs1312953205 1443 dbSNP
rs530996263 1449 dbSNP
rs1397325754 1456 dbSNP
rs1285632195 1460 dbSNP
rs1331774430 1474 dbSNP
rs1312804154 1486 dbSNP
rs894979262 1487 dbSNP
rs912203179 1500 dbSNP
rs943711761 1501 dbSNP
rs553878315 1504 dbSNP
rs78411303 1505 dbSNP
rs1200638885 1507 dbSNP
rs947334586 1507 dbSNP
rs1422149536 1519 dbSNP
rs1256816680 1520 dbSNP
rs11710770 1527 dbSNP
rs1483316380 1535 dbSNP
rs905708367 1536 dbSNP
rs561571072 1541 dbSNP
rs938078831 1544 dbSNP
rs1265674918 1545 dbSNP
rs956061474 1547 dbSNP
rs1353051668 1552 dbSNP
rs1414137651 1567 dbSNP
rs36062714 1569 dbSNP
rs1455517669 1576 dbSNP
rs546541334 1583 dbSNP
rs1055624808 1587 dbSNP
rs896448484 1590 dbSNP
rs566878347 1594 dbSNP
rs1388068010 1598 dbSNP
rs1441720943 1599 dbSNP
rs1325819993 1603 dbSNP
rs1329537373 1605 dbSNP
rs914630433 1610 dbSNP
rs1015638794 1621 dbSNP
rs897399821 1625 dbSNP
rs995782578 1627 dbSNP
rs1160067827 1644 dbSNP
rs1280463427 1657 dbSNP
rs1027132003 1687 dbSNP
rs1437019329 1694 dbSNP
rs554735015 1694 dbSNP
rs1267734890 1698 dbSNP
rs1268047046 1703 dbSNP
rs1334965195 1704 dbSNP
rs763870707 1705 dbSNP
rs933590436 1705 dbSNP
rs1330585312 1706 dbSNP
rs1211086913 1708 dbSNP
rs1442032520 1712 dbSNP
rs1332073668 1713 dbSNP
rs1325890145 1733 dbSNP
rs1439135686 1742 dbSNP
rs1394079202 1747 dbSNP
rs534578040 1748 dbSNP
rs983695920 1751 dbSNP
rs56403232 1754 dbSNP
rs941669941 1757 dbSNP
rs985194365 1761 dbSNP
rs1019778607 1762 dbSNP
rs965191603 1766 dbSNP
rs201595677 1770 dbSNP
rs28514900 1771 dbSNP
rs1378110678 1772 dbSNP
rs1181445650 1778 dbSNP
rs988422661 1783 dbSNP
rs577886870 1784 dbSNP
rs912922902 1788 dbSNP
rs1252051676 1795 dbSNP
rs1208903575 1816 dbSNP
rs1458516691 1818 dbSNP
rs1281475108 1822 dbSNP
rs1250751974 1824 dbSNP
rs1388881811 1826 dbSNP
rs1277094089 1832 dbSNP
rs1404916705 1834 dbSNP
rs1232646982 1835 dbSNP
rs537240209 1836 dbSNP
rs1370704521 1837 dbSNP
rs1321472226 1840 dbSNP
rs1329984505 1840 dbSNP
rs1437495222 1843 dbSNP
rs947280365 1846 dbSNP
rs557234514 1852 dbSNP
rs1288326274 1853 dbSNP
rs1402908241 1859 dbSNP
rs927111943 1862 dbSNP
rs937172753 1870 dbSNP
rs1281857295 1874 dbSNP
rs1057005005 1875 dbSNP
rs896556733 1877 dbSNP
rs949479868 1885 dbSNP
rs1214508855 1888 dbSNP
rs1037018969 1890 dbSNP
rs1209270623 1891 dbSNP
rs1481971101 1891 dbSNP
rs1347644386 1894 dbSNP
rs897178997 1895 dbSNP
rs891800957 1903 dbSNP
rs995731204 1909 dbSNP
rs1049130693 1921 dbSNP
rs889922461 1926 dbSNP
rs1448922480 1928 dbSNP
rs1007461060 1929 dbSNP
rs573739259 1931 dbSNP
rs1011549592 1934 dbSNP
rs1366733923 1942 dbSNP
rs1472507267 1943 dbSNP
rs542747572 1945 dbSNP
rs1372621855 1946 dbSNP
rs1428247592 1948 dbSNP
rs1417037521 1950 dbSNP
rs1307768506 1953 dbSNP
rs1403547197 1955 dbSNP
rs1022148281 1961 dbSNP
rs1398250499 1969 dbSNP
rs1311196238 1970 dbSNP
rs1207821685 1971 dbSNP
rs1339431235 1981 dbSNP
rs1272577823 1985 dbSNP
rs1227474744 1991 dbSNP
rs1229037720 1993 dbSNP
rs1299423938 1996 dbSNP
rs964848394 1997 dbSNP
rs1291462259 2001 dbSNP
rs1414224255 2009 dbSNP
rs1354788408 2011 dbSNP
rs1339570601 2016 dbSNP
rs1227431771 2017 dbSNP
rs1352490603 2021 dbSNP
rs1169341786 2022 dbSNP
rs1280691867 2025 dbSNP
rs1484202324 2026 dbSNP
rs559059155 2035 dbSNP
rs1162215684 2039 dbSNP
rs532061091 2040 dbSNP
rs1441965089 2042 dbSNP
rs1253238693 2047 dbSNP
rs1189245412 2048 dbSNP
rs974812451 2052 dbSNP
rs62263901 2054 dbSNP
rs1447820438 2056 dbSNP
rs1168368957 2060 dbSNP
rs1271474723 2063 dbSNP
rs1232824544 2065 dbSNP
rs1329922192 2066 dbSNP
rs1230218212 2067 dbSNP
rs1225332085 2068 dbSNP
rs1370932556 2069 dbSNP
rs1297437247 2077 dbSNP
rs1436891562 2083 dbSNP
rs1378639463 2099 dbSNP
rs1323462762 2102 dbSNP
rs1467901734 2108 dbSNP
rs1411971131 2109 dbSNP
rs1301645244 2110 dbSNP
rs572814360 2114 dbSNP
rs1435213910 2118 dbSNP
rs1407866894 2132 dbSNP
rs1192180041 2135 dbSNP
rs1470104710 2140 dbSNP
rs1321919568 2145 dbSNP
rs544715207 2149 dbSNP
rs1433824985 2150 dbSNP
rs1262514760 2152 dbSNP
rs373617437 2153 dbSNP
rs1315096046 2159 dbSNP
rs1306193095 2162 dbSNP
rs1313779158 2162 dbSNP
rs565553393 2163 dbSNP
rs1300810215 2168 dbSNP
rs954856848 2172 dbSNP
rs1255364486 2173 dbSNP
rs376631471 2180 dbSNP
rs550718523 2188 dbSNP
rs1450959177 2194 dbSNP
rs370767197 2198 dbSNP
rs1177411288 2199 dbSNP
rs561147280 2208 dbSNP
rs530104649 2214 dbSNP
rs1188247417 2215 dbSNP
rs1193281561 2217 dbSNP
rs1268273183 2227 dbSNP
rs1435326501 2231 dbSNP
rs1485575509 2232 dbSNP
rs1260086381 2233 dbSNP
rs1211422791 2235 dbSNP
rs1349827293 2240 dbSNP
rs1277863619 2249 dbSNP
rs547084864 2259 dbSNP
rs566885148 2261 dbSNP
rs539001507 2262 dbSNP
rs1160758783 2263 dbSNP
rs1385877580 2270 dbSNP
rs1437086338 2271 dbSNP
rs941709037 2272 dbSNP
rs372741666 2277 dbSNP
rs1375056349 2278 dbSNP
rs1293803372 2281 dbSNP
rs1427999505 2287 dbSNP
rs973115758 2292 dbSNP
rs916217455 2293 dbSNP
rs1369225830 2301 dbSNP
rs947839573 2302 dbSNP
rs1486640090 2304 dbSNP
rs1046127022 2305 dbSNP
rs1209979339 2314 dbSNP
rs1339817330 2316 dbSNP
rs762600419 2323 dbSNP
rs1224708028 2328 dbSNP
rs1306449568 2328 dbSNP
rs571509062 2334 dbSNP
rs537346431 2336 dbSNP
rs1354181473 2337 dbSNP
rs1312788340 2344 dbSNP
rs1410840120 2347 dbSNP
rs965080143 2355 dbSNP
rs183552813 2359 dbSNP
rs1461625503 2362 dbSNP
rs893701885 2386 dbSNP
rs1011224576 2387 dbSNP
rs1474265076 2390 dbSNP
rs188742081 2390 dbSNP
rs900495611 2392 dbSNP
rs968361404 2394 dbSNP
rs144394375 2395 dbSNP
rs111581299 2397 dbSNP
rs572884478 2398 dbSNP
rs1015487731 2399 dbSNP
rs963689390 2404 dbSNP
rs974054444 2405 dbSNP
rs1473114708 2409 dbSNP
rs544977330 2410 dbSNP
rs916285860 2415 dbSNP
rs1337923209 2416 dbSNP
rs1327327581 2420 dbSNP
rs993060051 2422 dbSNP
rs917115535 2423 dbSNP
rs1395580439 2441 dbSNP
rs1328157077 2444 dbSNP
rs1459956533 2455 dbSNP
rs1417175038 2456 dbSNP
rs968984513 2457 dbSNP
rs1410369835 2463 dbSNP
rs1365446673 2471 dbSNP
rs558273784 2472 dbSNP
rs575495338 2475 dbSNP
rs544522422 2477 dbSNP
rs561120640 2479 dbSNP
rs927691705 2486 dbSNP
rs1271932314 2492 dbSNP
rs1205181392 2501 dbSNP
rs868508843 2514 dbSNP
rs1037132234 2515 dbSNP
rs1238858521 2520 dbSNP
rs1411398119 2522 dbSNP
rs3106357 2529 dbSNP
rs1164861187 2530 dbSNP
rs1052301058 2533 dbSNP
rs1223320443 2537 dbSNP
rs1393866277 2542 dbSNP
rs1319125442 2545 dbSNP
rs4358249 2548 dbSNP
rs946690386 2552 dbSNP
rs1323744350 2561 dbSNP
rs778878030 2566 dbSNP
rs1395410701 2569 dbSNP
rs890021888 2571 dbSNP
rs1452237933 2581 dbSNP
rs1007166117 2584 dbSNP
rs1448210032 2599 dbSNP
rs1282788249 2603 dbSNP
rs1418486826 2604 dbSNP
rs1291312018 2607 dbSNP
rs1483609268 2616 dbSNP
rs1041587064 2635 dbSNP
rs540506472 2636 dbSNP
rs1207681176 2639 dbSNP
rs900507449 2642 dbSNP
rs901360822 2643 dbSNP
rs1250288390 2646 dbSNP
rs1270971516 2648 dbSNP
rs1432991914 2649 dbSNP
rs1009905445 2656 dbSNP
rs1004956983 2659 dbSNP
rs1019992523 2663 dbSNP
rs1181953094 2669 dbSNP
rs968477982 2682 dbSNP
rs1143339 2686 dbSNP
rs191534509 2688 dbSNP
rs958856209 2695 dbSNP
rs1193133802 2699 dbSNP
rs1390384363 2706 dbSNP
rs1486305892 2710 dbSNP
rs992779971 2712 dbSNP
rs1431418865 2715 dbSNP
rs1260197703 2720 dbSNP
rs917041521 2726 dbSNP
rs1347531261 2732 dbSNP
rs961881733 2733 dbSNP
rs879691406 2737 dbSNP
rs1337570433 2743 dbSNP
rs956486486 2748 dbSNP
rs1415453886 2749 dbSNP
rs1356076725 2755 dbSNP
rs1314641704 2759 dbSNP
rs1448589213 2760 dbSNP
rs988288886 2760 dbSNP
rs972774724 2765 dbSNP
rs946503962 2766 dbSNP
rs1416906350 2775 dbSNP
rs1475239328 2777 dbSNP
rs1420663470 2783 dbSNP
rs1483142688 2784 dbSNP
rs552497676 2784 dbSNP
rs1233774249 2790 dbSNP
rs569282732 2794 dbSNP
rs76582209 2799 dbSNP
rs921159057 2801 dbSNP
rs1272546650 2806 dbSNP
rs931413312 2812 dbSNP
rs771968385 2825 dbSNP
rs1048856736 2828 dbSNP
rs911243190 2829 dbSNP
rs1336953458 2830 dbSNP
rs1295066835 2831 dbSNP
rs942917363 2834 dbSNP
rs1378208964 2836 dbSNP
rs1298573662 2837 dbSNP
rs1041305181 2848 dbSNP
rs901308408 2852 dbSNP
rs946214844 2853 dbSNP
rs1041903193 2854 dbSNP
rs377410686 2858 dbSNP
rs1437600032 2861 dbSNP
rs1211526486 2862 dbSNP
rs904269648 2866 dbSNP
rs1482019751 2867 dbSNP
rs1180719049 2868 dbSNP
rs1179379760 2877 dbSNP
rs890451877 2883 dbSNP
rs1237805477 2886 dbSNP
rs1005005388 2888 dbSNP
rs1469894382 2894 dbSNP
rs182539741 2895 dbSNP
rs114700766 2918 dbSNP
rs894155360 2919 dbSNP
rs1307598076 2927 dbSNP
rs1225314445 2935 dbSNP
rs186644467 2936 dbSNP
rs1372688798 2941 dbSNP
rs1441139038 2941 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cauucuuCACGAAUGUAACGUc 5'
                 | |:|  |||||:| 
Target 5' -------GAGUU--CAUUGUAg 3'
 		1 - 13
2 
miRNA  3' cauUCUUCACGAAUGUAACguc 5'
             |||  ||  || ||||   
Target 5' gucAGA--UGAGUAGAUUG--- 3'
 		34 - 50
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000483793.1 | 3UTR | GAGUUCAUUGUAGAUUCUGGAUAUUAGCCCUUUGUCAGAUGAGUAGAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000483793.1 | 3UTR | CAAAAAUUUUCUCCCAUUCUGUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21032 Prostate cancer -0.261 8.6e-3 -0.162 7.2e-2 83 Click to see details
GSE21687 Ependynoma primary tumors -0.253 2.2e-2 -0.215 4.4e-2 64 Click to see details
GSE28260 Renal cortex and medulla 0.546 2.7e-2 0.489 4.5e-2 13 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.508 1.9e-1 -0.600 1.4e-1 5 Click to see details
GSE19350 CNS germ cell tumors -0.266 2.0e-1 0.156 3.1e-1 12 Click to see details
GSE32688 Pancreatic cancer -0.115 2.7e-1 -0.355 2.3e-2 32 Click to see details
GSE38226 Liver fibrosis 0.141 2.7e-1 0.263 1.2e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells 0.13 2.7e-1 0.014 4.7e-1 24 Click to see details
GSE28544 Breast cancer -0.12 2.9e-1 -0.061 3.9e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.112 3.2e-1 0.132 2.9e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.001 5.0e-1 -0.077 3.6e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.001 5.0e-1 -0.077 3.6e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP 0.648 0.01 0.560 0.02 13 Click to see details
KIRC -0.686 0.04 -0.214 0.32 7 Click to see details
BRCA -0.526 0.14 -0.486 0.16 6 Click to see details
KICH -0.615 0.19 -0.200 0.4 4 Click to see details
LIHC -0.812 0.2 -1.000 0.5 3 Click to see details
LUSC 0.532 0.23 0.600 0.2 4 Click to see details
HNSC -0.225 0.36 -0.100 0.44 5 Click to see details
STAD 0.283 0.36 0.600 0.2 4 Click to see details
PRAD -0.051 0.38 -0.108 0.26 37 Click to see details
PRAD -0.051 0.38 -0.108 0.26 37 Click to see details
PRAD -0.051 0.38 -0.108 0.26 37 Click to see details
PRAD -0.051 0.38 -0.108 0.26 37 Click to see details
PRAD -0.051 0.38 -0.108 0.26 37 Click to see details
PRAD -0.051 0.38 -0.108 0.26 37 Click to see details
162 hsa-miR-106a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056049 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT065618 CLIC4 chloride intracellular channel 4 2 4
MIRT071648 DICER1 dicer 1, ribonuclease III 2 4
MIRT081712 ZNF507 zinc finger protein 507 2 2
MIRT093589 SPCS3 signal peptidase complex subunit 3 2 2
MIRT094223 G3BP2 G3BP stress granule assembly factor 2 2 2
MIRT125225 KLHL15 kelch like family member 15 2 6
MIRT169562 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT179227 KMT2A lysine methyltransferase 2A 2 2
MIRT180842 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT248803 SESN2 sestrin 2 2 2
MIRT257843 FAM46A family with sequence similarity 46 member A 2 2
MIRT261799 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT368750 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT448814 FKBP1A FK506 binding protein 1A 2 4
MIRT448950 CDK19 cyclin dependent kinase 19 2 2
MIRT452980 CABP4 calcium binding protein 4 2 2
MIRT454110 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT456599 CHML CHM like, Rab escort protein 2 2 2
MIRT461652 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT464838 RPS27A ribosomal protein S27a 2 12
MIRT469511 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT471103 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT475451 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT478236 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT480179 CALM2 calmodulin 2 2 8
MIRT481376 ATG12 autophagy related 12 2 2
MIRT495841 PLXDC1 plexin domain containing 1 2 2
MIRT498772 PARP15 poly(ADP-ribose) polymerase family member 15 2 4
MIRT502394 GATA6 GATA binding protein 6 2 8
MIRT504543 ZNF417 zinc finger protein 417 2 6
MIRT504953 ZNRF2 zinc and ring finger 2 2 6
MIRT505044 ZNF226 zinc finger protein 226 2 2
MIRT505285 TRIM66 tripartite motif containing 66 2 6
MIRT508006 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT508372 SPTBN2 spectrin beta, non-erythrocytic 2 2 4
MIRT509026 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 2
MIRT509045 AKAP2 A-kinase anchoring protein 2 2 2
MIRT509640 ZNF354B zinc finger protein 354B 2 10
MIRT512961 KMO kynurenine 3-monooxygenase 2 4
MIRT517859 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT517944 TRIM59 tripartite motif containing 59 2 2
MIRT525900 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT529446 SLC28A2 solute carrier family 28 member 2 2 2
MIRT531095 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534557 RRAS2 RAS related 2 2 2
MIRT537004 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT538407 COX20 COX20, cytochrome c oxidase assembly factor 2 2
MIRT540635 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT546660 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT547958 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT552022 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT554238 SLBP stem-loop binding protein 2 2
MIRT555287 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT556139 MFF mitochondrial fission factor 2 2
MIRT556419 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT557258 HMGXB4 HMG-box containing 4 2 2
MIRT557318 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT557774 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT559634 AKAP10 A-kinase anchoring protein 10 2 2
MIRT561616 SESN3 sestrin 3 2 2
MIRT566174 PURA purine rich element binding protein A 2 2
MIRT567183 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT611357 LARP4B La ribonucleoprotein domain family member 4B 2 2
MIRT616553 ZNF512B zinc finger protein 512B 2 2
MIRT617308 FAM9C family with sequence similarity 9 member C 2 2
MIRT624899 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT627008 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627071 SF3A1 splicing factor 3a subunit 1 2 2
MIRT628271 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629231 CINP cyclin dependent kinase 2 interacting protein 2 2
MIRT629403 ADM2 adrenomedullin 2 2 2
MIRT629580 RFC2 replication factor C subunit 2 2 2
MIRT629631 WDR31 WD repeat domain 31 2 2
MIRT629796 GPR82 G protein-coupled receptor 82 2 2
MIRT629870 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT629916 POLR2D RNA polymerase II subunit D 2 2
MIRT629979 NARS asparaginyl-tRNA synthetase 2 2
MIRT630038 TERF2 telomeric repeat binding factor 2 2 2
MIRT630057 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT630151 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT630245 SMTNL2 smoothelin like 2 2 2
MIRT630274 PSMB5 proteasome subunit beta 5 2 2
MIRT630344 NKAP NFKB activating protein 2 2
MIRT630493 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT631628 ZNF383 zinc finger protein 383 2 2
MIRT632467 RPS15A ribosomal protein S15a 2 2
MIRT632509 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT632591 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632989 DUSP18 dual specificity phosphatase 18 2 2
MIRT633077 CXorf21 chromosome X open reading frame 21 2 2
MIRT635044 MYH11 myosin heavy chain 11 2 2
MIRT636646 CDK4 cyclin dependent kinase 4 2 2
MIRT637185 ROMO1 reactive oxygen species modulator 1 2 2
MIRT637918 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT642640 PTGR2 prostaglandin reductase 2 2 2
MIRT644231 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644659 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT645084 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645985 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646980 SCARB1 scavenger receptor class B member 1 2 2
MIRT647421 ODF4 outer dense fiber of sperm tails 4 2 2
MIRT648322 PLIN1 perilipin 1 2 2
MIRT648506 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT651460 XIAP X-linked inhibitor of apoptosis 2 2
MIRT656548 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT657371 HMGB1 high mobility group box 1 2 2
MIRT660828 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT660916 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661232 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT662840 OMD osteomodulin 2 2
MIRT662902 MED18 mediator complex subunit 18 2 2
MIRT663518 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663537 CCR6 C-C motif chemokine receptor 6 2 2
MIRT664345 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT666074 SSTR2 somatostatin receptor 2 2 2
MIRT667219 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT667756 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668647 DYM dymeclin 2 2
MIRT671471 FLYWCH2 FLYWCH family member 2 2 2
MIRT671488 SLC38A9 solute carrier family 38 member 9 2 2
MIRT671917 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672285 GP2 glycoprotein 2 2 2
MIRT674022 ANKRD9 ankyrin repeat domain 9 2 2
MIRT674212 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT674510 PRR23A proline rich 23A 2 2
MIRT675095 SNTB2 syntrophin beta 2 2 2
MIRT675261 ZNF431 zinc finger protein 431 2 2
MIRT680630 KIAA1456 KIAA1456 2 2
MIRT681609 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT681919 KAT7 lysine acetyltransferase 7 2 2
MIRT682042 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT682055 B4GALT7 beta-1,4-galactosyltransferase 7 2 4
MIRT683756 CPE carboxypeptidase E 2 2
MIRT690233 CENPK centromere protein K 2 2
MIRT699167 SMAD2 SMAD family member 2 2 2
MIRT699905 RUNDC1 RUN domain containing 1 2 2
MIRT704401 CTPS1 CTP synthase 1 2 2
MIRT706252 MKLN1 muskelin 1 2 2
MIRT708876 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT710788 IFNLR1 interferon lambda receptor 1 2 2
MIRT711947 SLC7A14 solute carrier family 7 member 14 2 2
MIRT712587 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT713335 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713901 IGF2R insulin like growth factor 2 receptor 2 2
MIRT714079 ZNF532 zinc finger protein 532 2 2
MIRT714881 GOLPH3 golgi phosphoprotein 3 2 2
MIRT715190 FKTN fukutin 2 2
MIRT717798 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT721434 ARPC4 actin related protein 2/3 complex subunit 4 2 2
MIRT722777 PDE3A phosphodiesterase 3A 2 2
MIRT723415 FAM208B family with sequence similarity 208 member B 2 2
MIRT732545 AURKA aurora kinase A 1 0
MIRT732549 MYCN MYCN proto-oncogene, bHLH transcription factor 1 0
MIRT733122 YAP1 Yes associated protein 1 3 0
MIRT733238 VEGFA vascular endothelial growth factor A 1 0
MIRT733725 TGFB1 transforming growth factor beta 1 2 0
MIRT733728 NOTCH1 notch 1 2 0
MIRT733829 RUNX2 runt related transcription factor 2 1 0
MIRT733830 BMP2 bone morphogenetic protein 2 1 0
MIRT736953 SMAD7 SMAD family member 7 3 0
MIRT737029 FOXQ1 forkhead box Q1 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-106a Cisplatin approved 84093 Quantitative real-time PCR ovarian cancer cells 24348845 2014 up-regulated
miR-106a Cisplatin approved 84093 Microarray ovarian cancer 19237188 2009 down-regulated
miR-106a Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 down-regulated
miR-106a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-106a Diethylstilbestrol approved 448537 Quantitative real-time PCR mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-106a 5-Fluorouracil approved 3385 Microarray HCT-8 colon cancer cell line 19956872 2010 down-regulated
miR-106a Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines HTR-8 20417706 2010 up-regulated
miR-106a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-106a Bicalutamide approved 2375 Microarray prostate 22674191 2012 down-regulated
miR-106a Narangin NULL 442428 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-106a Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 up-regulated
miR-106a Tamoxifen approved 2733526 Quantitative real-time PCR rat liver 17343880 2007 up-regulated
miR-106a 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 up-regulated
miR-106a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-106a-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-106a-3p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-106a-3p Apatinib 11315474 NSC772886 resistant Low Gastric Cancer cell line (SGC-7901)
hsa-miR-106a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-106a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-106a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-106a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-106a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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