miRTarBase - #MIRT499104


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pre-miRNA Information
pre-miRNA hsa-mir-4323   
Genomic Coordinates chr19: 42133445 - 42133513
Description Homo sapiens miR-4323 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4323
Sequence 42| CAGCCCCACAGCCUCAGA |59
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs549311114 1 dbSNP
rs896027609 6 dbSNP
rs1057502968 11 dbSNP
rs773276005 11 dbSNP
rs1454618841 12 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AGRN   
Synonyms AGRIN, CMS8, CMSPPD
Description agrin
Transcript NM_198576   
Expression
Putative miRNA Targets on AGRN
3'UTR of AGRN
(miRNA target sites are highlighted)		 
>AGRN|NM_198576|3'UTR
   1 GCTGGCACCAGAGCCCCGCGCCCGCTGTAATTATTTTCTATTTTTGTAAACTTGTTGCTTTTTGATATGATTTTCTTGCC
  81 TGAGTGTTGGCCGGAGGGACTGCTGGCCCGGCCTCCCTTCCGTCCAGGCAGCCGTGCTGCAGACAGACCTAGTGCCGAGG
 161 GATGGACAGGCGAGGTGGCAGCGTGGAGGGCTCGGCGTGGATGGCAGCCTCAGGACACACACCCCTGCCTCAAGGTGCTG
 241 AGCCCCCGCCTTGCACTGCGCCTGCCCCACGGTGTCCCCGCCGGGAAGCAGCCCCGGCTCCTGAATCACCCTCGCTCCGT
 321 CAGGCGGGACTCGTGTCCCAGAGAGGAAGGGGCTGCTGAGGTCTGATGGGGCCCTTCCTCCGGGTGACCCCACAGGGCCT
 401 TTCCAAGCCCCCATTTGAGCTGCTCCTTCCTGTGTGTGCTCTGGGCCCTGCCTCGGCCTCCTGCGCCAATACTGTGACTT
 481 CCAAACAATGTTACTGCTGGGCACAGCTCTGCGTTGCTCCCGTGCTGCCTGCGCCAGCCCCAGGCTGCTGAGGAGCAGAG
 561 GCCAGACCAGGGCCGATCTGGGTGTCCTGACCCTCAGCTGGCCCTGCCCAGCCACCCTGGACGTGACCGTATCCCTCTGC
 641 CACACCCCAGGCCCTGCGAGGGGCTATCGAGAGGAGCTCACTGTGGGATGGGGTTGACCTCTGCCGCCTGCCTGGGTATC
 721 TGGGCCTGGCCATGGCTGTGTTCTTCATGTGTTGATTTTATTTGACCCCTGGAGTGGTGGGTCTCATCTTTCCCATCTCG
 801 CCTGAGAGCGGCTGAGGGCTGCCTCACTGCAAATCCTCCCCACAGCGTCAGTGAAAGTCGTCCTTGTCTCAGAATGACCA
 881 GGGGCCAGCCAGTGTCTGACCAAGGTCAAGGGGCAGGTGCAGAGGTGGCAGGGATGGCTCCGAAGCCAGAAATGCCTTAA
 961 ACTGCAACGTCCCGTCCCTTCCCCACCCCCATCCCATCCCCACCCCCAGCCCCAGCCCAGTCCTCCTAGGAGCAGGACCC
1041 GATGAAGCGGGCGGCGGTGGGGCTGGGTGCCGTGTTACTAACTCTAGTATGTTTCTGTGTCAATCGCTGTGAAATAAAGT
1121 CTGAAAACTTTAAAAGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agaCUCCGACACCCCGAc 5'
             | ||| |||||||| 
Target 5' cggGCGGCGGTGGGGCTg 3'
 1048 - 1065 159.00 -24.00
2 
miRNA  3' agACUCC-GAC-ACCCCGac 5'
            ||||| ||| ||||||  
Target 5' gcTGAGGTCTGATGGGGCcc 3'
 355 - 374 144.00 -25.20
3 
miRNA  3' agACUCCGAC-ACCCCGAc 5'
            || ||  | |||||:| 
Target 5' acTGTGG--GATGGGGTTg 3'
 680 - 696 128.00 -20.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
263157 20 ClinVar
1185529 157 ClinVar
COSN19725335 20 COSMIC
COSN31527837 53 COSMIC
COSN26732508 57 COSMIC
COSN29206190 92 COSMIC
COSN30543760 97 COSMIC
COSN31590976 97 COSMIC
COSN31552308 123 COSMIC
COSN31538193 197 COSMIC
COSN31512871 284 COSMIC
COSN30164793 394 COSMIC
COSN30164803 396 COSMIC
COSN21205485 404 COSMIC
COSN24297743 471 COSMIC
COSN28682726 479 COSMIC
COSN26649875 566 COSMIC
COSN15003181 974 COSMIC
rs2710872 157 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1366386171 9 dbSNP
rs1440765677 10 dbSNP
rs1290001243 12 dbSNP
rs1301911757 14 dbSNP
rs1364848496 15 dbSNP
rs1220497232 16 dbSNP
rs758552329 18 dbSNP
rs1022051904 19 dbSNP
rs3121561 20 dbSNP
rs751669640 21 dbSNP
rs1465204936 22 dbSNP
rs776719537 24 dbSNP
rs373699293 25 dbSNP
rs530126570 26 dbSNP
rs1191912593 28 dbSNP
rs1407514384 30 dbSNP
rs892797048 39 dbSNP
rs1161690755 41 dbSNP
rs1389783019 48 dbSNP
rs1394884915 51 dbSNP
rs1160664877 52 dbSNP
rs1401002742 57 dbSNP
rs2465136 57 dbSNP
rs1333302246 59 dbSNP
rs1357313342 69 dbSNP
rs572679323 76 dbSNP
rs1284753798 93 dbSNP
rs983295641 94 dbSNP
rs1176247058 96 dbSNP
rs1237401223 96 dbSNP
rs907683556 97 dbSNP
rs1248008729 99 dbSNP
rs540454935 102 dbSNP
rs981558673 107 dbSNP
rs560265131 110 dbSNP
rs900243574 111 dbSNP
rs1238159340 114 dbSNP
rs1384130202 116 dbSNP
rs1424580401 121 dbSNP
rs931708041 122 dbSNP
rs1051849821 123 dbSNP
rs891406747 126 dbSNP
rs765519795 132 dbSNP
rs546593512 134 dbSNP
rs552381784 135 dbSNP
rs1011692859 137 dbSNP
rs922007614 138 dbSNP
rs933414463 141 dbSNP
rs1021749225 147 dbSNP
rs1272784395 152 dbSNP
rs2710872 157 dbSNP
rs1257900167 159 dbSNP
rs1456845231 166 dbSNP
rs980154485 172 dbSNP
rs4308920 173 dbSNP
rs1451152466 176 dbSNP
rs1358902762 180 dbSNP
rs1243645322 183 dbSNP
rs1292002906 184 dbSNP
rs1463979980 192 dbSNP
rs1172782014 194 dbSNP
rs1396583810 195 dbSNP
rs370908455 197 dbSNP
rs983325343 198 dbSNP
rs907719578 202 dbSNP
rs566744281 206 dbSNP
rs973231691 207 dbSNP
rs1316499393 208 dbSNP
rs1220974704 210 dbSNP
rs1249193653 222 dbSNP
rs889432871 222 dbSNP
rs1053454056 224 dbSNP
rs921728092 225 dbSNP
rs1355716098 229 dbSNP
rs1178940133 237 dbSNP
rs568383209 248 dbSNP
rs1269654019 249 dbSNP
rs1452440059 255 dbSNP
rs1442289479 260 dbSNP
rs1262163286 261 dbSNP
rs113039247 265 dbSNP
rs1051453743 269 dbSNP
rs911525084 271 dbSNP
rs1416625573 272 dbSNP
rs1011196079 274 dbSNP
rs1456905712 275 dbSNP
rs1044066071 276 dbSNP
rs535889520 280 dbSNP
rs1424882955 281 dbSNP
rs1297245211 283 dbSNP
rs944296732 284 dbSNP
rs1053334577 295 dbSNP
rs148689211 296 dbSNP
rs544381837 297 dbSNP
rs1011723918 301 dbSNP
rs1035837515 302 dbSNP
rs1267327970 307 dbSNP
rs1382102824 310 dbSNP
rs1043602988 314 dbSNP
rs950948848 320 dbSNP
rs1284214771 321 dbSNP
rs905959191 323 dbSNP
rs1285842185 326 dbSNP
rs4308921 327 dbSNP
rs1007922976 329 dbSNP
rs1035695387 331 dbSNP
rs1185389665 333 dbSNP
rs1444789399 344 dbSNP
rs1016918867 346 dbSNP
rs959993002 347 dbSNP
rs1004881650 349 dbSNP
rs1421835521 352 dbSNP
rs1293170563 353 dbSNP
rs1014891080 354 dbSNP
rs1394768635 362 dbSNP
rs1198857922 368 dbSNP
rs963274317 370 dbSNP
rs59199047 372 dbSNP
rs973291081 374 dbSNP
rs1315514244 379 dbSNP
rs921732451 382 dbSNP
rs1459557084 383 dbSNP
rs185797292 384 dbSNP
rs1205019228 389 dbSNP
rs35068709 395 dbSNP
rs866918800 395 dbSNP
rs1239663055 399 dbSNP
rs192377440 409 dbSNP
rs2799072 413 dbSNP
rs1417779319 416 dbSNP
rs866347850 421 dbSNP
rs1479037523 423 dbSNP
rs1261068462 426 dbSNP
rs911634048 442 dbSNP
rs912363474 445 dbSNP
rs2799073 446 dbSNP
rs1052031887 455 dbSNP
rs183693482 456 dbSNP
rs1441187607 457 dbSNP
rs767369263 458 dbSNP
rs947610028 460 dbSNP
rs1336263020 465 dbSNP
rs187481882 466 dbSNP
rs1464907083 469 dbSNP
rs1429897060 474 dbSNP
rs13129 479 dbSNP
rs190399326 486 dbSNP
rs1446072127 493 dbSNP
rs1057471790 495 dbSNP
rs1219039519 500 dbSNP
rs374884633 501 dbSNP
rs1224508379 510 dbSNP
rs905557777 513 dbSNP
rs1320985601 514 dbSNP
rs4587516 522 dbSNP
rs1004912534 523 dbSNP
rs1461738134 530 dbSNP
rs560798701 533 dbSNP
rs367551550 534 dbSNP
rs531805883 535 dbSNP
rs1481366409 540 dbSNP
rs1177410344 543 dbSNP
rs1266247479 550 dbSNP
rs748928659 563 dbSNP
rs1028829188 570 dbSNP
rs1215681731 574 dbSNP
rs953300178 575 dbSNP
rs754693526 576 dbSNP
rs1465541011 579 dbSNP
rs28632009 583 dbSNP
rs1402546110 590 dbSNP
rs956443074 592 dbSNP
rs987778879 595 dbSNP
rs1365766479 597 dbSNP
rs996443911 606 dbSNP
rs8014 624 dbSNP
rs1256142668 628 dbSNP
rs528019046 629 dbSNP
rs979386292 634 dbSNP
rs927558687 652 dbSNP
rs547761851 654 dbSNP
rs1057284536 656 dbSNP
rs895934096 657 dbSNP
rs924020148 658 dbSNP
rs368776259 659 dbSNP
rs1400316931 661 dbSNP
rs771423645 669 dbSNP
rs777039724 670 dbSNP
rs746419910 677 dbSNP
rs1459622749 682 dbSNP
rs1304023559 683 dbSNP
rs1275127858 684 dbSNP
rs994773511 687 dbSNP
rs1345897736 690 dbSNP
rs914426460 691 dbSNP
rs1349278780 693 dbSNP
rs1221609653 696 dbSNP
rs1364025521 697 dbSNP
rs1029364217 699 dbSNP
rs947285315 701 dbSNP
rs1044291076 702 dbSNP
rs1284419864 706 dbSNP
rs889020330 707 dbSNP
rs938340211 712 dbSNP
rs1244299612 713 dbSNP
rs1009175080 717 dbSNP
rs1056836991 720 dbSNP
rs886168548 725 dbSNP
rs1411683758 727 dbSNP
rs1446593665 735 dbSNP
rs1018704753 740 dbSNP
rs1164386397 741 dbSNP
rs956471987 750 dbSNP
rs987809870 761 dbSNP
rs1418820571 767 dbSNP
rs769974010 768 dbSNP
rs899349455 771 dbSNP
rs538209094 779 dbSNP
rs1283590855 789 dbSNP
rs1218061984 796 dbSNP
rs571251627 798 dbSNP
rs558693641 800 dbSNP
rs1029242211 801 dbSNP
rs890751980 802 dbSNP
rs980462950 810 dbSNP
rs927562847 811 dbSNP
rs28701544 818 dbSNP
rs537918904 819 dbSNP
rs1462655956 830 dbSNP
rs1156942119 831 dbSNP
rs917399658 834 dbSNP
rs763259920 836 dbSNP
rs1160550635 838 dbSNP
rs1382305695 841 dbSNP
rs940758698 843 dbSNP
rs1036413831 847 dbSNP
rs375314521 848 dbSNP
rs554837868 860 dbSNP
rs1050435923 861 dbSNP
rs907547086 869 dbSNP
rs940411257 884 dbSNP
rs1237468677 886 dbSNP
rs1037458722 892 dbSNP
rs889043650 895 dbSNP
rs1008790120 902 dbSNP
rs1277071635 913 dbSNP
rs1018734412 914 dbSNP
rs1334809459 918 dbSNP
rs1204915834 926 dbSNP
rs892264938 930 dbSNP
rs574539068 942 dbSNP
rs1022037848 943 dbSNP
rs967808001 947 dbSNP
rs1233677690 952 dbSNP
rs1470353329 960 dbSNP
rs1377087600 963 dbSNP
rs540567628 969 dbSNP
rs1009166833 970 dbSNP
rs1354638426 972 dbSNP
rs1031399042 974 dbSNP
rs553738555 975 dbSNP
rs1011371949 977 dbSNP
rs1022327289 978 dbSNP
rs1290783816 979 dbSNP
rs1336013600 980 dbSNP
rs1436144661 983 dbSNP
rs577180370 987 dbSNP
rs959233910 988 dbSNP
rs969482910 990 dbSNP
rs993041834 992 dbSNP
rs1224653588 994 dbSNP
rs1437444248 995 dbSNP
rs917430687 997 dbSNP
rs1177077288 998 dbSNP
rs1197636300 1000 dbSNP
rs1273931030 1004 dbSNP
rs1240065865 1007 dbSNP
rs545847400 1008 dbSNP
rs1034173704 1012 dbSNP
rs962238785 1017 dbSNP
rs972207653 1018 dbSNP
rs1481334280 1021 dbSNP
rs992776828 1022 dbSNP
rs920705524 1024 dbSNP
rs930714507 1026 dbSNP
rs940361311 1028 dbSNP
rs1169164964 1038 dbSNP
rs1366682228 1039 dbSNP
rs1396653111 1041 dbSNP
rs1050874831 1042 dbSNP
rs1300976626 1049 dbSNP
rs910512610 1050 dbSNP
rs920324544 1052 dbSNP
rs372070223 1053 dbSNP
rs1325234716 1054 dbSNP
rs1395582244 1056 dbSNP
rs562666344 1057 dbSNP
rs892378955 1058 dbSNP
rs1009380734 1059 dbSNP
rs1043556217 1062 dbSNP
rs912085117 1063 dbSNP
rs531716527 1066 dbSNP
rs1294297119 1067 dbSNP
rs140354278 1072 dbSNP
rs368154235 1073 dbSNP
rs1426638924 1083 dbSNP
rs892742082 1085 dbSNP
rs1451319091 1090 dbSNP
rs1010902512 1091 dbSNP
rs1043729493 1092 dbSNP
rs1367053119 1097 dbSNP
rs761535671 1098 dbSNP
rs1425649107 1104 dbSNP
rs1339237277 1106 dbSNP
rs1033767471 1118 dbSNP
rs960370698 1127 dbSNP
rs968555373 1132 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agaCUCCGACACCCCGAc 5'
             | ||| |||||||| 
Target 5' cggGCGGCGGUGGGGCUg 3'
 		2 - 19
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_198576 | 3UTR | AGGAGCAGGACCCGAUGAAGCGGGCGGCGGUGGGGCUGGGUGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_198576 | 3UTR | AGGACCCGAUGAAGCGGGCGGCGGUGGGGCUGGGUGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000379370.2 | 3UTR | GCGGGCGGCGGUGGGGCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
64 hsa-miR-4323 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT052834 NOL11 nucleolar protein 11 1 1
MIRT082489 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT117166 PER1 period circadian clock 1 2 2
MIRT157951 TMEM184B transmembrane protein 184B 2 2
MIRT286013 TVP23B trans-golgi network vesicle protein 23 homolog B 2 2
MIRT310457 REST RE1 silencing transcription factor 2 2
MIRT338984 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT404223 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT451439 TJP3 tight junction protein 3 2 2
MIRT463541 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT466981 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT479627 CDC25A cell division cycle 25A 2 2
MIRT487983 SEC14L3 SEC14 like lipid binding 3 2 4
MIRT488661 ELAVL3 ELAV like RNA binding protein 3 2 2
MIRT489925 RTKN rhotekin 2 2
MIRT490209 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT494896 ZNF662 zinc finger protein 662 2 2
MIRT495380 RELT RELT, TNF receptor 2 2
MIRT495549 ANKRD65 ankyrin repeat domain 65 2 2
MIRT499104 AGRN agrin 2 2
MIRT500036 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501135 SLC2A1 solute carrier family 2 member 1 2 2
MIRT505573 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT508164 ABCC5 ATP binding cassette subfamily C member 5 2 8
MIRT512383 PHB2 prohibitin 2 2 2
MIRT512719 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT520904 STMN1 stathmin 1 2 2
MIRT526361 TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 2 2
MIRT526847 GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 2 2
MIRT526945 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 4
MIRT527028 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT527988 TSLP thymic stromal lymphopoietin 2 2
MIRT532202 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT533691 TMEM86A transmembrane protein 86A 2 2
MIRT535020 PRMT7 protein arginine methyltransferase 7 2 4
MIRT535054 PQLC1 PQ loop repeat containing 1 2 2
MIRT538987 BCL2L2 BCL2 like 2 2 2
MIRT552232 SART3 squamous cell carcinoma antigen recognized by T-cells 3 2 2
MIRT553259 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT555157 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT565202 TSC22D4 TSC22 domain family member 4 2 2
MIRT566199 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT566526 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT568464 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT572231 ATG2A autophagy related 2A 2 2
MIRT573096 NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 2 2
MIRT573326 RFC5 replication factor C subunit 5 2 2
MIRT632802 KIAA2022 neurite extension and migration factor 2 2
MIRT646433 ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 2 3
MIRT647826 MTG1 mitochondrial ribosome associated GTPase 1 2 4
MIRT652191 TRIM44 tripartite motif containing 44 2 2
MIRT653800 SIRPA signal regulatory protein alpha 2 2
MIRT666949 PKHD1 PKHD1, fibrocystin/polyductin 2 2
MIRT684833 SCAI suppressor of cancer cell invasion 2 2
MIRT687294 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT700188 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT701784 MSL2 MSL complex subunit 2 2 2
MIRT705958 ACY1 aminoacylase 1 2 2
MIRT705998 ABHD14A-ACY1 ABHD14A-ACY1 readthrough 2 2
MIRT717107 PXDC1 PX domain containing 1 2 2
MIRT717586 VTA1 vesicle trafficking 1 2 2
MIRT722148 SLC2A8 solute carrier family 2 member 8 2 2
MIRT723479 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT725221 PEA15 phosphoprotein enriched in astrocytes 15 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4323 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-mir-4323 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-4323 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-4323 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-4323 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-4323 Vincristine 5978 approved sensitive cell line (W1)
hsa-mir-4323 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-4323 Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4323 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4323 Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4323 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4323 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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