pre-miRNA Information
pre-miRNA hsa-mir-4640   
Genomic Coordinates chr6: 30890883 - 30890972
Description Homo sapiens miR-4640 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4640-5p
Sequence 9| UGGGCCAGGGAGCAGCUGGUGGG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1392105945 7 dbSNP
rs939712790 9 dbSNP
rs762825841 15 dbSNP
rs71552023 20 dbSNP
rs1305909531 21 dbSNP
rs750017220 21 dbSNP
rs1375436057 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B32FZJ miR-4640 Safety Biomarker (SAF) Clinical/Experimental Data Expression lower Urine Quantitative polymerase chain reaction
Gene Information
Gene Symbol NPHP3   
Synonyms CFAP31, MKS7, NPH3, RHPD, RHPD1, SLSN3
Description nephrocystin 3
Transcript NM_153240   
Expression
Putative miRNA Targets on NPHP3
3'UTR of NPHP3
(miRNA target sites are highlighted)
>NPHP3|NM_153240|3'UTR
   1 TAGCAGCAGTTAGAATTCTTTGCAAATGTACCTTAAGACAAAATAATTAAACATTTGGAACATTTGAATTTGAAACTTTA
  81 AAAAAATGTTGTACGAAATTTTACTACGTGTGATTTAACTGCTATTTGTATGAAGTTGTATTGGATTACATTAAGTTGGA
 161 ATTGTGATTATGTCTGTTTTAGTTGTTTAAAAGAATTTTCCTATTATATGGTATCCAAGGATGTAGACACATTAGAATTA
 241 TAAGAAGACATGAGGAGCAAATCATGAAGAGCGGATTGGTCTTTGTTCAACAAGAGCTGGCAGAGTAGTTAAGACAAGGA
 321 GTTCAAAAATTCCATGAATCTTGGCCAGGCATGGTGGCTCATGCCTGTAATCCCACCACTTTGGGAGGGTGATGCAGGAG
 401 GATCACTTGAGGCCAGGAGTTGGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAAAT
 481 TAGCTGGACCTGGTGGCGCATGCCTGTAATCCTAGCTACTCAGGAGGCTGAGGCATGAGAATCGCTTGAACTCAGCAAGT
 561 GGAGGTTGCTATGAGCTGAGATTGTGCCAGTTCATTCCACCCTGGGCAACAGGGTGAGACTCTGTCTCAAAAAAAAAAAA
 641 AAAAAAAAAAAGAATTCCATGATTCTTTTGAGCTCTCAAGAGCTACTTTAGCCTTGCCATTCCTCTTGCTTTTCAGCAGT
 721 AGTCTGGCCCAATTCTCTACCTCAAAGGAAAGTTTCAAGGATTAAAGGGTTAATGTTTATGAACGATTCAAATTGTCTTC
 801 AGTGAAACACATTAGTCACAAGAATCCCTGATTGCTGCACTTTAAAAAATTCTTTACCTTTTCCTTGAGCAGATTGGTCC
 881 AGTCCCTCTGCTTTCTGTTCTGTCTACATTGTGTATTATTTATTACTATATAGTATATGTATCTGCATAATGTCTGAAGT
 961 CATTAATGCAGTAACAGGTCAAGCTCTTTAGCATTCTTTGACTTTTCCCAAAATATAGATATGACATTCTCCTTTATCTT
1041 CCTTCTTAGATGGCCTAAATCTGTCTCTTCATTTACCTCAAACTCAAATTAGTATGCCATTTTCATACTGAAAATTAAAT
1121 ATTTTTATGGATTTTATAAATATTGCAACATTTTAGATATTGTTTTGGACCATTTGTGTATTTATATATAATAAAATCAT
1201 CAATTTAATACTTGTAAGATCCTAACATGTATTGATTGTAAAAGTGAAATATGTAATAGCCACACTTCACTGTTTTAAAA
1281 TAAAAGTGCAATTTCAAGTTCAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggguGGUCGACGAGGGACCGGGu 5'
              :|||| |:  :||||||| 
Target 5' ctttTCAGCAGTAGTCTGGCCCa 3'
709 - 731 159.00 -23.90
2
miRNA  3' ggGUGGUCGAC-----GAGGGACCGGgu 5'
            ||  ||:||     |  |||||||  
Target 5' gcCAGGAGTTGGAGACCAGCCTGGCCaa 3'
412 - 439 133.00 -21.30
3
miRNA  3' ggguGGUCGACGAGGGACCGGgu 5'
              |||  ||  :|:|||||  
Target 5' aattCCA--TGAATCTTGGCCag 3'
328 - 348 119.00 -16.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
343373 46 ClinVar
343372 124 ClinVar
343371 139 ClinVar
903616 141 ClinVar
903615 178 ClinVar
343370 231 ClinVar
343369 266 ClinVar
901547 351 ClinVar
900990 437 ClinVar
343368 519 ClinVar
900989 626 ClinVar
343367 652 ClinVar
343366 653 ClinVar
343365 654 ClinVar
343364 655 ClinVar
343363 657 ClinVar
343362 692 ClinVar
343361 759 ClinVar
343360 784 ClinVar
343359 785 ClinVar
343358 815 ClinVar
902587 852 ClinVar
902586 926 ClinVar
343357 1020 ClinVar
343356 1078 ClinVar
900923 1094 ClinVar
343355 1098 ClinVar
343354 1121 ClinVar
343353 1176 ClinVar
903379 1184 ClinVar
903378 1188 ClinVar
343352 1213 ClinVar
COSN30101980 13 COSMIC
COSN30112054 18 COSMIC
COSN30506452 29 COSMIC
COSN30456642 32 COSMIC
COSN28016684 58 COSMIC
COSN30110428 66 COSMIC
COSN28838774 80 COSMIC
COSN26986864 88 COSMIC
COSN23555600 95 COSMIC
COSN16727307 108 COSMIC
COSN30174288 132 COSMIC
COSN30158358 157 COSMIC
COSN5037251 181 COSMIC
COSN6750410 208 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs745863319 10 dbSNP
rs1433937574 11 dbSNP
rs1489145024 26 dbSNP
rs1427566542 28 dbSNP
rs1189781639 30 dbSNP
rs761940786 31 dbSNP
rs774591752 32 dbSNP
rs1195677020 33 dbSNP
rs764314027 36 dbSNP
rs763085697 37 dbSNP
rs775842215 45 dbSNP
rs530016526 46 dbSNP
rs746285540 47 dbSNP
rs972198119 48 dbSNP
rs1325973595 52 dbSNP
rs1172557524 58 dbSNP
rs1425629331 64 dbSNP
rs1370552209 75 dbSNP
rs559443516 77 dbSNP
rs1397456886 88 dbSNP
rs1167245527 89 dbSNP
rs1173532039 93 dbSNP
rs1374098949 94 dbSNP
rs148415169 103 dbSNP
rs1053504440 106 dbSNP
rs745339249 107 dbSNP
rs111995127 108 dbSNP
rs1428061534 108 dbSNP
rs371974858 124 dbSNP
rs886058001 139 dbSNP
rs1244560325 140 dbSNP
rs538987591 141 dbSNP
rs1205435580 144 dbSNP
rs1262733365 147 dbSNP
rs1028682342 150 dbSNP
rs919515967 152 dbSNP
rs1191280640 162 dbSNP
rs972761172 167 dbSNP
rs760268682 180 dbSNP
rs1490451883 181 dbSNP
rs963377903 187 dbSNP
rs1273910133 188 dbSNP
rs1159457185 194 dbSNP
rs1384671547 197 dbSNP
rs1398634930 200 dbSNP
rs998129461 202 dbSNP
rs1016681878 211 dbSNP
rs756922816 220 dbSNP
rs753577987 231 dbSNP
rs543992318 234 dbSNP
rs1239532641 238 dbSNP
rs779618111 249 dbSNP
rs1003311829 250 dbSNP
rs1348242957 255 dbSNP
rs1275272759 265 dbSNP
rs11708200 266 dbSNP
rs1193041334 267 dbSNP
rs1265902911 271 dbSNP
rs1042781823 272 dbSNP
rs113746355 273 dbSNP
rs767556 281 dbSNP
rs1405993986 284 dbSNP
rs1166664281 295 dbSNP
rs915563092 297 dbSNP
rs1009904390 298 dbSNP
rs1323253342 306 dbSNP
rs1350229881 319 dbSNP
rs992880401 351 dbSNP
rs1306201779 358 dbSNP
rs1333826933 365 dbSNP
rs2369831 375 dbSNP
rs1432200508 377 dbSNP
rs35559859 378 dbSNP
rs1355570481 387 dbSNP
rs938959506 390 dbSNP
rs1413337141 394 dbSNP
rs1422708322 396 dbSNP
rs111771204 401 dbSNP
rs1196942818 403 dbSNP
rs972229160 404 dbSNP
rs755878327 405 dbSNP
rs1418150627 412 dbSNP
rs1053464667 415 dbSNP
rs1250765593 420 dbSNP
rs752598447 430 dbSNP
rs146004671 433 dbSNP
rs1462040238 434 dbSNP
rs539230132 437 dbSNP
rs1394196482 439 dbSNP
rs549268866 444 dbSNP
rs1222223574 445 dbSNP
rs767356739 458 dbSNP
rs867269869 478 dbSNP
rs1313308348 480 dbSNP
rs534379440 482 dbSNP
rs142599290 484 dbSNP
rs997889402 488 dbSNP
rs901098948 497 dbSNP
rs1265285454 498 dbSNP
rs1228158513 499 dbSNP
rs1251275455 510 dbSNP
rs553049189 517 dbSNP
rs3891704 519 dbSNP
rs1258708580 521 dbSNP
rs1485549708 523 dbSNP
rs998681543 527 dbSNP
rs904354545 529 dbSNP
rs185678453 533 dbSNP
rs1042814107 543 dbSNP
rs948516202 544 dbSNP
rs1206243777 556 dbSNP
rs1302769544 567 dbSNP
rs774242763 568 dbSNP
rs991435466 571 dbSNP
rs1412634480 582 dbSNP
rs1301320891 589 dbSNP
rs569648267 590 dbSNP
rs1356912257 596 dbSNP
rs138023872 600 dbSNP
rs938309243 607 dbSNP
rs1382872095 610 dbSNP
rs919542079 612 dbSNP
rs74755960 614 dbSNP
rs2887563 619 dbSNP
rs942199694 623 dbSNP
rs1156702698 626 dbSNP
rs1420586432 628 dbSNP
rs1251227441 629 dbSNP
rs1208380384 630 dbSNP
rs909397784 640 dbSNP
rs1486017335 641 dbSNP
rs986673336 643 dbSNP
rs953493964 644 dbSNP
rs1185536982 647 dbSNP
rs1160959944 652 dbSNP
rs1194200413 652 dbSNP
rs1245736516 652 dbSNP
rs1394330384 652 dbSNP
rs1412576147 652 dbSNP
rs1443125729 652 dbSNP
rs1454540001 652 dbSNP
rs1455183067 652 dbSNP
rs886058000 652 dbSNP
rs986033075 652 dbSNP
rs369921629 653 dbSNP
rs886057999 654 dbSNP
rs1217950549 655 dbSNP
rs77627568 655 dbSNP
rs886057998 655 dbSNP
rs79224795 657 dbSNP
rs1317889474 664 dbSNP
rs954291435 665 dbSNP
rs150864525 668 dbSNP
rs1265785861 670 dbSNP
rs115127733 673 dbSNP
rs1213729767 677 dbSNP
rs1212727060 679 dbSNP
rs1252322604 683 dbSNP
rs1477028443 687 dbSNP
rs886057997 692 dbSNP
rs1031580245 697 dbSNP
rs1032287294 702 dbSNP
rs998712707 735 dbSNP
rs968584947 741 dbSNP
rs546383026 747 dbSNP
rs1007232412 749 dbSNP
rs1013130040 756 dbSNP
rs888819979 757 dbSNP
rs116338839 759 dbSNP
rs897970596 768 dbSNP
rs1036951897 769 dbSNP
rs759981084 770 dbSNP
rs376015619 784 dbSNP
rs6774366 785 dbSNP
rs1336429725 788 dbSNP
rs1233500189 789 dbSNP
rs897476437 791 dbSNP
rs1036006310 793 dbSNP
rs1206613441 794 dbSNP
rs1233332426 795 dbSNP
rs1056011412 797 dbSNP
rs937333625 803 dbSNP
rs1419729637 805 dbSNP
rs141464909 815 dbSNP
rs1476330288 815 dbSNP
rs531921170 817 dbSNP
rs1413234905 821 dbSNP
rs1403619149 832 dbSNP
rs981450817 833 dbSNP
rs1227077585 842 dbSNP
rs1355583698 850 dbSNP
rs192360684 852 dbSNP
rs913704401 858 dbSNP
rs1357726453 861 dbSNP
rs111502613 864 dbSNP
rs763093068 869 dbSNP
rs1233598189 874 dbSNP
rs1283225302 881 dbSNP
rs1452655762 888 dbSNP
rs988363953 896 dbSNP
rs1050616988 899 dbSNP
rs1387462323 902 dbSNP
rs1318121307 919 dbSNP
rs570076170 926 dbSNP
rs1188936004 939 dbSNP
rs1485867375 939 dbSNP
rs1237052745 940 dbSNP
rs574493424 971 dbSNP
rs1169675485 975 dbSNP
rs1420287218 975 dbSNP
rs976561846 977 dbSNP
rs1163757639 981 dbSNP
rs956730101 985 dbSNP
rs986056333 986 dbSNP
rs559039251 989 dbSNP
rs1333105101 1000 dbSNP
rs1338299971 1002 dbSNP
rs1432318335 1005 dbSNP
rs1270306455 1014 dbSNP
rs923963504 1016 dbSNP
rs1184286447 1018 dbSNP
rs1363818120 1019 dbSNP
rs186828918 1020 dbSNP
rs867074191 1024 dbSNP
rs1246481995 1027 dbSNP
rs1348327062 1035 dbSNP
rs1207099943 1038 dbSNP
rs1486422613 1041 dbSNP
rs1440957419 1046 dbSNP
rs1195555495 1047 dbSNP
rs1265262745 1050 dbSNP
rs1219762662 1059 dbSNP
rs1021922927 1061 dbSNP
rs1397361266 1067 dbSNP
rs1435766512 1070 dbSNP
rs897557103 1075 dbSNP
rs1400493502 1077 dbSNP
rs886057996 1078 dbSNP
rs748455325 1079 dbSNP
rs1402149956 1093 dbSNP
rs886057995 1098 dbSNP
rs576904017 1121 dbSNP
rs1432175597 1127 dbSNP
rs558602820 1128 dbSNP
rs1371577643 1129 dbSNP
rs1006798486 1130 dbSNP
rs1352568673 1135 dbSNP
rs1207179383 1140 dbSNP
rs1268940938 1143 dbSNP
rs1246162132 1146 dbSNP
rs887979783 1152 dbSNP
rs1255471234 1160 dbSNP
rs1055937779 1162 dbSNP
rs1455126469 1162 dbSNP
rs1035468440 1170 dbSNP
rs1363797705 1171 dbSNP
rs937595372 1175 dbSNP
rs183658380 1176 dbSNP
rs1046157911 1181 dbSNP
rs191849490 1186 dbSNP
rs7632096 1188 dbSNP
rs1036035697 1194 dbSNP
rs1456133292 1198 dbSNP
rs1321495047 1208 dbSNP
rs1337327532 1210 dbSNP
rs886057994 1213 dbSNP
rs1289255385 1229 dbSNP
rs1367442796 1230 dbSNP
rs1226776680 1234 dbSNP
rs1275173659 1236 dbSNP
rs1488838527 1246 dbSNP
rs936469050 1252 dbSNP
rs1005849249 1256 dbSNP
rs1439950031 1262 dbSNP
rs1182918823 1263 dbSNP
rs536097809 1271 dbSNP
rs1164115011 1286 dbSNP
rs1448995272 1298 dbSNP
rs925111450 1301 dbSNP
rs888073597 1302 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ggguggucgacGAGGGACCGGGu 5'
                     :||:||  |:| 
Target 5' ------cccaaUUCUCUACCUCa 3'
1 - 17
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_153240 | 3UTR | CCAUGAUUCUUUUGAGCUCUCAAGAGCUACUUUAGCCUUGCCAUUCCUCUUGCUUUUCAGCAGUAGUCUGGCCCAAUUCUCUACCUCAAAGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_153240 | 3UTR | UCCAUGAUUCUUUUGAGCUCUCAAGAGCUACUUUAGCCUUGCCAUUCCUCUUGCUUUUCAGCAGUAGUCUGGCCCAAUUCUCUACCUCAAAGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_153240 | 3UTR | AUUCCAUGAUUCUUUUGAGCUCUCAAGAGCUACUUUAGCCUUGCCAUUCCUCUUGCUUUUCAGCAGUAGUCUGGCCCAAUUCUCUACCUCAAAGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_153240 | 3UTR | GAGCUCUCAAGAGCUACUUUAGCCUUGCCAUUCCUCUUGCUUUUCAGCAGUAGUCUGGCCCAAUUCUCUACCUCAAAGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_153240 | 3UTR | UCAAGAGCUACUUUAGCCUUGCCAUUCCUCUUGCUUUUCAGCAGUAGUCUGGCCCAAUUCUCUACCUCAAAGGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000326682.8 | 3UTR | CCCAAUUCUCUACCUCAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4640-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100106 ABT1 activator of basal transcription 1 2 8
MIRT248144 LMBR1L limb development membrane protein 1 like 2 2
MIRT327062 KLHL15 kelch like family member 15 2 2
MIRT347231 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT450221 CENPN centromere protein N 2 2
MIRT451264 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT452701 C1orf226 chromosome 1 open reading frame 226 2 2
MIRT453212 CERS1 ceramide synthase 1 2 2
MIRT454822 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT454883 RAD50 RAD50 double strand break repair protein 2 2
MIRT455783 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT455858 TMEM254 transmembrane protein 254 2 2
MIRT457615 UPK3BL uroplakin 3B like 1 2 2
MIRT457822 ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein 2 4
MIRT458344 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458376 ITM2C integral membrane protein 2C 2 2
MIRT458928 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT459066 WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2 2
MIRT460138 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT460818 FSTL4 follistatin like 4 2 2
MIRT461285 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT462738 EFNB1 ephrin B1 2 2
MIRT464556 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT477910 DUSP2 dual specificity phosphatase 2 2 2
MIRT479073 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 4
MIRT479534 CDC5L cell division cycle 5 like 2 4
MIRT485628 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT489896 PPIC peptidylprolyl isomerase C 2 4
MIRT490737 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT491201 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT492681 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT494593 ATG7 autophagy related 7 2 2
MIRT495061 PADI3 peptidyl arginine deiminase 3 2 4
MIRT496623 TMEM67 transmembrane protein 67 2 2
MIRT497177 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT498217 TLN2 talin 2 2 2
MIRT498306 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT499668 NPHP3 nephrocystin 3 2 2
MIRT508080 ANKRD52 ankyrin repeat domain 52 2 2
MIRT509707 ANKRD23 ankyrin repeat domain 23 2 2
MIRT509841 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT512814 ARRDC2 arrestin domain containing 2 2 2
MIRT513353 SLIT1 slit guidance ligand 1 2 2
MIRT514293 FXYD5 FXYD domain containing ion transport regulator 5 2 2
MIRT516598 FAM89A family with sequence similarity 89 member A 2 4
MIRT516616 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT518348 CCL5 C-C motif chemokine ligand 5 2 2
MIRT520130 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT522072 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT526461 OSBPL5 oxysterol binding protein like 5 2 2
MIRT528278 MBL2 mannose binding lectin 2 2 2
MIRT534844 RAB15 RAB15, member RAS oncogene family 2 4
MIRT542245 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT543299 ZNF585B zinc finger protein 585B 2 2
MIRT552456 ZNF410 zinc finger protein 410 2 2
MIRT553641 TJAP1 tight junction associated protein 1 2 2
MIRT557103 HOXA3 homeobox A3 2 2
MIRT570782 FANCA Fanconi anemia complementation group A 2 2
MIRT630912 ZMAT2 zinc finger matrin-type 2 2 2
MIRT631034 ZNF878 zinc finger protein 878 2 2
MIRT639017 AAK1 AP2 associated kinase 1 2 2
MIRT648596 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT648939 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT652834 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT659347 CSRP1 cysteine and glycine rich protein 1 2 2
MIRT664163 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT670511 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT671246 TMEM41B transmembrane protein 41B 2 2
MIRT672120 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT672313 CD3D CD3d molecule 2 2
MIRT672543 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT673036 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT673814 DARS aspartyl-tRNA synthetase 2 2
MIRT674858 GINM1 glycoprotein integral membrane 1 2 2
MIRT674970 SH3BP2 SH3 domain binding protein 2 2 2
MIRT675185 KIF1C kinesin family member 1C 2 2
MIRT675219 UGDH UDP-glucose 6-dehydrogenase 2 2
MIRT675558 MED16 mediator complex subunit 16 2 2
MIRT682566 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT684640 PDE4C phosphodiesterase 4C 2 2
MIRT689722 ATXN2 ataxin 2 2 2
MIRT693594 SLC39A1 solute carrier family 39 member 1 2 2
MIRT704745 CDKN2B cyclin dependent kinase inhibitor 2B 2 2
MIRT712779 ZNF154 zinc finger protein 154 2 2
MIRT718118 OTOF otoferlin 2 2
MIRT720115 SAMD4A sterile alpha motif domain containing 4A 2 2
MIRT720275 EIF1AD eukaryotic translation initiation factor 1A domain containing 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4640 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4640-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4640-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4640-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4640-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4640-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4640-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4640-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

Error report submission