miRTarBase - #MIRT499742


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pre-miRNA Information
pre-miRNA hsa-mir-637   
Genomic Coordinates chr19: 3961414 - 3961512
Synonyms MIRN637, hsa-mir-637, MIR637
Description Homo sapiens miR-637 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-637
Sequence 61| ACUGGGGGCUUUCGGGCUCUGCGU |84
Evidence Experimental
Experiments SAGE
Expression Profile
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN518997 2 COSMIC
COSN1082357 6 COSMIC
COSN13804010 13 COSMIC
COSN1082358 14 COSMIC
COSN30450169 14 COSMIC
COSN30532059 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1416171403 2 dbSNP
rs200224173 4 dbSNP
rs1475121792 9 dbSNP
rs202144891 13 dbSNP
rs767027646 14 dbSNP
rs529226642 16 dbSNP
rs751534327 17 dbSNP
rs758718359 17 dbSNP
rs149472696 20 dbSNP
rs773105166 21 dbSNP
rs543903246 22 dbSNP
rs374248027 24 dbSNP
Putative Targets

Gene Information
Gene Symbol USH1G   
Synonyms ANKS4A, SANS
Description USH1 protein network component sans
Transcript NM_173477   
Expression
Putative miRNA Targets on USH1G
3'UTR of USH1G
(miRNA target sites are highlighted)		 
>USH1G|NM_173477|3'UTR
   1 CCGGGGGCTCCTCTCCCCAGACCAAAATGAATTGCAAGTTGCCACAACCTATGGTGGGGTCTCGAGGTCCTCACAGTTGC
  81 CAGCCCTGCAGCCCCCTTCCCCAGGAGCAAGGACCAGTTGGGGCGACTCCTTTGAAAGTCTGTCTGCACCTTGAAGCTGA
 161 GGGTGTGGCCTGGAGGCACCAGAGGGGCAAGAGAATGTTCCGGAACTCCAGTTCTGAGGGGTCTTGAAGGCCCTGAGCCA
 241 CCCATTCTGAGCAGCCGTAAAGGACATGTAGACTTGGGGGAGGCCTGCCCCAGAGGGAGGGCAGGGGCATCGGAACTGGA
 321 TGAGAGTGTGGGAGGTGGATGCGGGAGGGTGCACCTGTCCCGGGCGCCGTGGCCTCTCCCACCCCTCCCCTGATGGTCTT
 401 GTTCTCTTGTGCTCAGGCCAGAGACTTGCTCACTTCCTGCATTGTTGTGAAGGGAAGAGTTTGGGCTGCCTCCCCTCCTC
 481 CCGTCCACCCCAGAGGGGAAGTTCCTCAGCCAGACTCTTCAGCCAAATGCCCCAACTTTCAGTCTGTACCCCATCCCAAG
 561 CATAGCCAGCTCCCCCTCCTTCACCTAGTGGTCAAGGCCCGGAGCTGGAAAGCCGGGTTGGGGTGGGGTGGGGGTACTGA
 641 CGCCCTTCCCAGCTCATCCAGGGGTGGAGCCTGGCCTGTCTTCCTCCAACCTCCCCCTTTTTCGTTGTGCAGCCTGGCCC
 721 CCCAGGGACCCCAGAGGGCCAGGGCGCTAGATGCAAGGTGCTAGACCAATGGGCTGCAGTATTATAGCCCCCAGGCCTGG
 801 CAGGCATGCGCTGGGCTAGAGAAAGGTGTCCGCCAACCTCCTCAGTCTCCCAGGCCTGGGACAGGCAGAACAGGGTGTGG
 881 CTGGGTGTCAGGCCTGGGGTGGGTAAGTCCTGCGATGTGGACACTGGAGAAAGTGGATCCTCTAAACTGCAGATTGTCCC
 961 CAGGTCACCAGGGCTGTGTGCGTGTGCATGTTTGTGTGCATGTATGCGTGTGTGCATGCATGTGTGTGTAAGTATGTGGT
1041 ATGTGTGAGCACGGGTGTGTGCTTGGGTGTGTGTGTTCTTGCATACATGTGTGCGTGTGTGTGCACGTGAACGCGTGCGT
1121 GTTTGTGTGTGTGCATGCATGTGTGTGCATGTGTGTGTGTGCATGCATGTGTGTGTGTGTGCATGTGTGCGTGTGTGCAC
1201 ACTCACGTTGGGTGGTGTTTGGTAGGTTTCCCTCCAGGTCTGGTAGGGACTGGGCTGTTGCGTGATTCTGCGTGGATCGG
1281 GGGTAAGAGAGCTCACCTGTGTCCCAGCCCTCTGATGGTGGTGAGACCAGGGGAAAGGCCAGCTCAGAGGGTGGTCACAG
1361 CATGTGTCCTCTGACGTATGCCCCCAAAGCTCTCCAGCCAGACTGAGGTCACAGATGTGGGAGAGTCCCTGATGAGCCCG
1441 CTGACACGTGTGCGCCCCTTTGCACCCCATGCAGAGGTGCTCTCCTCCTTTCTCAGCCATGGCCCCCCATCCCTGACCTC
1521 AGCTTGGGAAGCAGCTCCTGCTGGGAGCATGGCCTCAGCCCCCAGCATCTCCTGGGGCCCCCATGGCTGGGGCAGGGGAA
1601 AGAGAGCCCTCAAAGGCCTCTTTCTGGTCTGTCTGGGGGTTCCCATTCCCACACATGTGCCCAGAGTAGGGGGCATGGAG
1681 GAGATGGTCCCTGTCCTACTGCAGGACACTGAGGGCTTGGCTGCCTGCCACCGCCATCTGGAGCCCACCACAGCTCTTCT
1761 CCCTGTTCTCTGGGCCTGAGCCTGGGGCCACCCCCAAGTGCCGACTTGTTTCTCCCAGAGCCCCAGGTGCTGCCCCTTCT
1841 CTCCTGTTCCTCGTCCGTTTACTGCCGCAGCCCCTCCTGGTTCTTCTGGTGCTGGGGTGGAGCAGGCTCTGTGCTCCCAC
1921 CACTGTACCCCGAATCCCTCCTGCAGGCTCATTGCCACTTTTGTAGAGAATGTTCTCTATCAGTATCGT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugCGUCUCGGGCUUUCGGGGGUCa 5'
            ||| :|||:   ||||||||| 
Target 5' gaGCATGGCCT--CAGCCCCCAGc 3'
 1545 - 1566 166.00 -26.60
2 
miRNA  3' ugCGUC-UCGGGCUUUCGGGGGUCa 5'
            || | ||: : | ||||||||| 
Target 5' ggGCTGCAGTATTATAGCCCCCAGg 3'
 771 - 795 162.00 -23.74
3 
miRNA  3' ugCGUCUCGGGCUUUCGGGGGUCa 5'
            |:: ||||:|  : ||||||| 
Target 5' ttGTGCAGCCTG--GCCCCCCAGg 3'
 705 - 726 158.00 -26.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1183119 3 ClinVar
325052 49 ClinVar
325051 63 ClinVar
325050 95 ClinVar
889401 198 ClinVar
325049 202 ClinVar
889400 233 ClinVar
889399 256 ClinVar
325048 279 ClinVar
325047 371 ClinVar
891844 482 ClinVar
325046 498 ClinVar
325045 553 ClinVar
891843 567 ClinVar
325044 571 ClinVar
891842 680 ClinVar
891841 704 ClinVar
891588 776 ClinVar
325043 809 ClinVar
891587 831 ClinVar
891586 940 ClinVar
325042 1018 ClinVar
891585 1052 ClinVar
325041 1053 ClinVar
325040 1093 ClinVar
890035 1098 ClinVar
890034 1112 ClinVar
325039 1119 ClinVar
890033 1130 ClinVar
890032 1154 ClinVar
325038 1162 ClinVar
890031 1174 ClinVar
325036 1182 ClinVar
325037 1182 ClinVar
890030 1191 ClinVar
325035 1224 ClinVar
325034 1303 ClinVar
889343 1376 ClinVar
889342 1447 ClinVar
325033 1656 ClinVar
325032 1719 ClinVar
325031 1732 ClinVar
889341 1821 ClinVar
325030 1900 ClinVar
325029 1906 ClinVar
891775 1922 ClinVar
325028 1987 ClinVar
369224 1990 ClinVar
COSN30125285 6 COSMIC
COSN16938109 7 COSMIC
COSN31488509 13 COSMIC
COSN28846769 38 COSMIC
COSN30177985 64 COSMIC
COSN25951458 69 COSMIC
COSN30193194 74 COSMIC
COSN30522229 99 COSMIC
COSN31587752 168 COSMIC
COSN30513429 221 COSMIC
COSN30531918 249 COSMIC
COSN29217114 436 COSMIC
COSN5865525 466 COSMIC
COSN22117010 520 COSMIC
COSN19298180 730 COSMIC
COSN6111938 895 COSMIC
COSN30017314 1106 COSMIC
COSN7455318 1121 COSMIC
COSN21763508 1272 COSMIC
COSN19491282 1453 COSMIC
COSN23399143 1733 COSMIC
COSN5221538 1963 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1224779659 1 dbSNP
rs146004909 2 dbSNP
rs372068582 3 dbSNP
rs754374776 7 dbSNP
rs764308497 10 dbSNP
rs368231718 13 dbSNP
rs1159258037 15 dbSNP
rs1195269119 16 dbSNP
rs775570788 18 dbSNP
rs1469580556 20 dbSNP
rs924003689 34 dbSNP
rs1201144337 35 dbSNP
rs767766308 38 dbSNP
rs1241329655 44 dbSNP
rs1213446236 46 dbSNP
rs199648830 49 dbSNP
rs756229183 51 dbSNP
rs998184111 53 dbSNP
rs563126068 58 dbSNP
rs113765180 63 dbSNP
rs529630489 64 dbSNP
rs1376693357 66 dbSNP
rs1240168782 74 dbSNP
rs569986070 75 dbSNP
rs958836687 81 dbSNP
rs1306530906 84 dbSNP
rs1229000897 85 dbSNP
rs1385077212 88 dbSNP
rs376850581 90 dbSNP
rs527247025 94 dbSNP
rs886053388 95 dbSNP
rs1227821340 105 dbSNP
rs181973786 111 dbSNP
rs1450369858 124 dbSNP
rs1337262922 125 dbSNP
rs1196925607 126 dbSNP
rs1005613359 138 dbSNP
rs1054371228 144 dbSNP
rs1289258137 145 dbSNP
rs1455135816 149 dbSNP
rs935827811 171 dbSNP
rs1182245664 179 dbSNP
rs1234546704 180 dbSNP
rs540652275 181 dbSNP
rs1343114942 185 dbSNP
rs753894091 186 dbSNP
rs1471733273 191 dbSNP
rs888150950 198 dbSNP
rs977188577 200 dbSNP
rs578014773 201 dbSNP
rs557845589 202 dbSNP
rs916974100 205 dbSNP
rs372221620 210 dbSNP
rs991195291 222 dbSNP
rs190522968 223 dbSNP
rs1447890431 231 dbSNP
rs1294004899 233 dbSNP
rs1041163836 235 dbSNP
rs1017175846 241 dbSNP
rs1257736075 247 dbSNP
rs1340254412 249 dbSNP
rs1485078501 253 dbSNP
rs984301455 256 dbSNP
rs942896710 257 dbSNP
rs1260426611 261 dbSNP
rs1025742682 263 dbSNP
rs1258101740 265 dbSNP
rs1475940076 267 dbSNP
rs1222563842 274 dbSNP
rs1372156617 278 dbSNP
rs886053387 279 dbSNP
rs1170035637 280 dbSNP
rs1400448456 283 dbSNP
rs1054065355 284 dbSNP
rs936654730 288 dbSNP
rs923998585 290 dbSNP
rs978166207 291 dbSNP
rs949406974 295 dbSNP
rs1018756285 302 dbSNP
rs1006930837 304 dbSNP
rs1296172456 308 dbSNP
rs575100426 310 dbSNP
rs893791238 311 dbSNP
rs918012760 312 dbSNP
rs1209884460 318 dbSNP
rs935879976 320 dbSNP
rs1486578515 324 dbSNP
rs992630691 325 dbSNP
rs1213829591 340 dbSNP
rs186770264 342 dbSNP
rs555190258 343 dbSNP
rs1383777137 345 dbSNP
rs1375536202 349 dbSNP
rs535347408 359 dbSNP
rs1288013995 360 dbSNP
rs1424908189 361 dbSNP
rs566785681 362 dbSNP
rs1034668675 363 dbSNP
rs984091765 365 dbSNP
rs374435759 368 dbSNP
rs1025225199 369 dbSNP
rs1288389465 371 dbSNP
rs782516019 371 dbSNP
rs993802481 382 dbSNP
rs552665867 383 dbSNP
rs1385825368 385 dbSNP
rs1383966676 387 dbSNP
rs1321904575 392 dbSNP
rs1370508930 409 dbSNP
rs1233310569 414 dbSNP
rs1303786407 416 dbSNP
rs1349999824 431 dbSNP
rs1427167074 439 dbSNP
rs1260046430 442 dbSNP
rs539434387 447 dbSNP
rs752734293 456 dbSNP
rs1007449847 468 dbSNP
rs1264846854 472 dbSNP
rs570408837 473 dbSNP
rs75035213 482 dbSNP
rs1267016964 483 dbSNP
rs777858100 490 dbSNP
rs569461974 498 dbSNP
rs34699124 499 dbSNP
rs1342960652 507 dbSNP
rs1455466776 509 dbSNP
rs1251878205 511 dbSNP
rs1054437692 513 dbSNP
rs1001162406 515 dbSNP
rs917045903 517 dbSNP
rs1326358458 529 dbSNP
rs1305628744 539 dbSNP
rs1294624966 540 dbSNP
rs991641936 544 dbSNP
rs111899313 553 dbSNP
rs1317427508 556 dbSNP
rs528602466 567 dbSNP
rs1263127666 568 dbSNP
rs111611253 571 dbSNP
rs1254458716 572 dbSNP
rs546646559 574 dbSNP
rs1176975342 576 dbSNP
rs533372588 578 dbSNP
rs917990755 582 dbSNP
rs1251885223 598 dbSNP
rs1055246525 599 dbSNP
rs937166224 600 dbSNP
rs1166420385 601 dbSNP
rs1025837661 604 dbSNP
rs1460918320 605 dbSNP
rs545091670 614 dbSNP
rs1460324250 615 dbSNP
rs927190738 618 dbSNP
rs1374011744 620 dbSNP
rs1177668127 621 dbSNP
rs1393019317 623 dbSNP
rs1291340651 624 dbSNP
rs1481607997 625 dbSNP
rs976969968 631 dbSNP
rs1274726700 633 dbSNP
rs1305343161 638 dbSNP
rs1427549084 641 dbSNP
rs532775278 642 dbSNP
rs1481919862 649 dbSNP
rs1180674069 653 dbSNP
rs1438553765 657 dbSNP
rs1257389918 660 dbSNP
rs1475612569 666 dbSNP
rs965926292 666 dbSNP
rs1018393062 669 dbSNP
rs1428104237 676 dbSNP
rs1007346797 677 dbSNP
rs55744500 680 dbSNP
rs1194110220 703 dbSNP
rs1032315413 704 dbSNP
rs918518607 706 dbSNP
rs1374761541 720 dbSNP
rs1414882797 721 dbSNP
rs972348663 728 dbSNP
rs1257319918 731 dbSNP
rs1359467091 733 dbSNP
rs903126810 740 dbSNP
rs965037605 745 dbSNP
rs1424549029 746 dbSNP
rs1209166693 752 dbSNP
rs1019309242 759 dbSNP
rs55847044 776 dbSNP
rs575376060 778 dbSNP
rs1055549283 779 dbSNP
rs1240383204 789 dbSNP
rs561522683 792 dbSNP
rs35184411 796 dbSNP
rs1032470868 804 dbSNP
rs1330338248 805 dbSNP
rs1389122478 806 dbSNP
rs886053386 809 dbSNP
rs747640918 810 dbSNP
rs1435214658 812 dbSNP
rs767040276 819 dbSNP
rs902737106 827 dbSNP
rs977400332 831 dbSNP
rs146007618 832 dbSNP
rs1427658217 833 dbSNP
rs1042678430 843 dbSNP
rs1289151921 845 dbSNP
rs115905441 847 dbSNP
rs553241289 851 dbSNP
rs1365707353 855 dbSNP
rs539014541 874 dbSNP
rs1179807605 879 dbSNP
rs1275061627 886 dbSNP
rs779459863 887 dbSNP
rs1237211116 893 dbSNP
rs995066862 900 dbSNP
rs1282736871 905 dbSNP
rs1446564766 905 dbSNP
rs1216573415 914 dbSNP
rs1418546576 917 dbSNP
rs911356647 922 dbSNP
rs1467257966 924 dbSNP
rs1191546329 925 dbSNP
rs142437952 926 dbSNP
rs1252090334 929 dbSNP
rs1454533117 934 dbSNP
rs896524267 937 dbSNP
rs112293979 940 dbSNP
rs938072206 943 dbSNP
rs1462550090 955 dbSNP
rs1032411547 960 dbSNP
rs537126229 965 dbSNP
rs1199620359 972 dbSNP
rs909296684 981 dbSNP
rs568192417 982 dbSNP
rs931167517 994 dbSNP
rs966694229 1001 dbSNP
rs918486002 1007 dbSNP
rs749663203 1011 dbSNP
rs1014550746 1014 dbSNP
rs895666575 1015 dbSNP
rs780234900 1018 dbSNP
rs888219256 1023 dbSNP
rs1334650982 1024 dbSNP
rs965006428 1026 dbSNP
rs1048129198 1027 dbSNP
rs1468800552 1028 dbSNP
rs1455059232 1030 dbSNP
rs1469502845 1030 dbSNP
rs760396641 1030 dbSNP
rs1404493952 1035 dbSNP
rs912268146 1035 dbSNP
rs1459388791 1039 dbSNP
rs1336511584 1040 dbSNP
rs1401630480 1041 dbSNP
rs1463358818 1041 dbSNP
rs1041317824 1045 dbSNP
rs918217926 1045 dbSNP
rs756392131 1048 dbSNP
rs549572410 1050 dbSNP
rs1157042410 1051 dbSNP
rs536064705 1052 dbSNP
rs113583471 1053 dbSNP
rs1232748255 1054 dbSNP
rs1274101782 1056 dbSNP
rs1032519138 1057 dbSNP
rs1211416893 1059 dbSNP
rs1270570549 1062 dbSNP
rs1001015730 1066 dbSNP
rs1205189900 1068 dbSNP
rs986057551 1068 dbSNP
rs1253887055 1071 dbSNP
rs958191366 1071 dbSNP
rs1473975470 1072 dbSNP
rs1186633524 1074 dbSNP
rs1186532229 1077 dbSNP
rs1283823166 1077 dbSNP
rs374828527 1077 dbSNP
rs690566 1093 dbSNP
rs137943342 1094 dbSNP
rs1331540636 1095 dbSNP
rs116670727 1098 dbSNP
rs1414257222 1101 dbSNP
rs1352445299 1102 dbSNP
rs1034251000 1103 dbSNP
rs761480955 1104 dbSNP
rs550587833 1106 dbSNP
rs1247471315 1107 dbSNP
rs888271506 1108 dbSNP
rs114353953 1112 dbSNP
rs751686069 1113 dbSNP
rs561862648 1114 dbSNP
rs541618266 1115 dbSNP
rs1049636049 1118 dbSNP
rs182142592 1119 dbSNP
rs1041139202 1123 dbSNP
rs1475978897 1123 dbSNP
rs943700161 1125 dbSNP
rs1434597485 1127 dbSNP
rs559327953 1130 dbSNP
rs911504003 1132 dbSNP
rs1316955279 1134 dbSNP
rs1380602438 1134 dbSNP
rs768758380 1134 dbSNP
rs1278362489 1141 dbSNP
rs1383383534 1141 dbSNP
rs1162578670 1143 dbSNP
rs1327191082 1150 dbSNP
rs1227891635 1151 dbSNP
rs1036907013 1152 dbSNP
rs1299496557 1152 dbSNP
rs189974618 1153 dbSNP
rs936833612 1153 dbSNP
rs1475669077 1154 dbSNP
rs1219953576 1158 dbSNP
rs925404358 1158 dbSNP
rs1202840294 1160 dbSNP
rs1190941829 1162 dbSNP
rs368387485 1162 dbSNP
rs886053385 1162 dbSNP
rs978192363 1162 dbSNP
rs1251468420 1163 dbSNP
rs1174895689 1164 dbSNP
rs1454089260 1164 dbSNP
rs1379871304 1167 dbSNP
rs1451744463 1168 dbSNP
rs535659863 1169 dbSNP
rs1269128747 1170 dbSNP
rs992590497 1170 dbSNP
rs762950394 1171 dbSNP
rs1368564652 1174 dbSNP
rs1439884847 1177 dbSNP
rs1224126108 1178 dbSNP
rs1236260018 1180 dbSNP
rs1332693934 1180 dbSNP
rs1259588233 1181 dbSNP
rs746904393 1182 dbSNP
rs796824729 1182 dbSNP
rs959397720 1182 dbSNP
rs1356637258 1183 dbSNP
rs1194594718 1186 dbSNP
rs1270103275 1186 dbSNP
rs1468366417 1186 dbSNP
rs1417815077 1187 dbSNP
rs1181213563 1190 dbSNP
rs912475260 1190 dbSNP
rs3859210 1191 dbSNP
rs979955665 1191 dbSNP
rs1215677668 1195 dbSNP
rs1394003912 1199 dbSNP
rs1342001597 1201 dbSNP
rs1268816437 1204 dbSNP
rs1293826147 1206 dbSNP
rs1369679538 1207 dbSNP
rs577242816 1208 dbSNP
rs932326414 1216 dbSNP
rs952550315 1218 dbSNP
rs143429562 1222 dbSNP
rs111922548 1224 dbSNP
rs993949629 1229 dbSNP
rs896921870 1231 dbSNP
rs1365055829 1254 dbSNP
rs1329550176 1261 dbSNP
rs1214740644 1262 dbSNP
rs966866405 1271 dbSNP
rs1421510607 1272 dbSNP
rs574552627 1273 dbSNP
rs1195774227 1275 dbSNP
rs1008343882 1278 dbSNP
rs1473645152 1279 dbSNP
rs1021096799 1283 dbSNP
rs992337221 1294 dbSNP
rs1013013 1303 dbSNP
rs1050009619 1304 dbSNP
rs1429636658 1308 dbSNP
rs1201117071 1309 dbSNP
rs1460247973 1312 dbSNP
rs1034366197 1313 dbSNP
rs762299762 1315 dbSNP
rs1297600857 1316 dbSNP
rs535628922 1328 dbSNP
rs1245629155 1330 dbSNP
rs753697757 1330 dbSNP
rs1204556241 1332 dbSNP
rs1440077337 1333 dbSNP
rs1271473728 1339 dbSNP
rs1218450209 1340 dbSNP
rs904033448 1344 dbSNP
rs887806013 1347 dbSNP
rs1314400759 1363 dbSNP
rs1027730549 1364 dbSNP
rs1306192577 1368 dbSNP
rs541417195 1368 dbSNP
rs1275989370 1369 dbSNP
rs897916910 1375 dbSNP
rs1208854492 1376 dbSNP
rs1256837056 1379 dbSNP
rs1486026942 1381 dbSNP
rs1183856805 1384 dbSNP
rs1417631026 1386 dbSNP
rs1426535375 1414 dbSNP
rs945508092 1420 dbSNP
rs1390744726 1425 dbSNP
rs1431497045 1427 dbSNP
rs1310974960 1428 dbSNP
rs1221920002 1437 dbSNP
rs148825489 1439 dbSNP
rs72844517 1447 dbSNP
rs184991093 1448 dbSNP
rs1050130364 1453 dbSNP
rs932328712 1454 dbSNP
rs1232803900 1457 dbSNP
rs952659682 1467 dbSNP
rs1312913789 1468 dbSNP
rs772797465 1473 dbSNP
rs777055662 1475 dbSNP
rs1212262076 1480 dbSNP
rs540112420 1484 dbSNP
rs777665444 1490 dbSNP
rs1026840892 1492 dbSNP
rs1485642862 1501 dbSNP
rs1187722881 1503 dbSNP
rs1248470624 1505 dbSNP
rs1464959394 1507 dbSNP
rs1406558575 1508 dbSNP
rs1394392316 1517 dbSNP
rs1178241741 1518 dbSNP
rs924981787 1532 dbSNP
rs769165276 1534 dbSNP
rs1177518456 1535 dbSNP
rs1343100042 1537 dbSNP
rs1479269332 1541 dbSNP
rs1320785499 1547 dbSNP
rs945077004 1556 dbSNP
rs913667139 1559 dbSNP
rs1439151491 1562 dbSNP
rs760694751 1567 dbSNP
rs1303387748 1571 dbSNP
rs1177319558 1577 dbSNP
rs992304430 1579 dbSNP
rs1368839915 1583 dbSNP
rs570830006 1590 dbSNP
rs550526184 1592 dbSNP
rs1316390114 1596 dbSNP
rs1209644477 1602 dbSNP
rs1270250936 1613 dbSNP
rs1231739192 1615 dbSNP
rs1198590982 1620 dbSNP
rs1246058002 1628 dbSNP
rs981462825 1629 dbSNP
rs952075985 1631 dbSNP
rs144265564 1643 dbSNP
rs374499352 1643 dbSNP
rs1192446676 1652 dbSNP
rs1405225076 1653 dbSNP
rs8067775 1656 dbSNP
rs889470597 1657 dbSNP
rs1027966300 1661 dbSNP
rs1460211728 1666 dbSNP
rs1325604349 1672 dbSNP
rs1307940371 1674 dbSNP
rs993467204 1675 dbSNP
rs1350999689 1677 dbSNP
rs1225606285 1694 dbSNP
rs1439283383 1701 dbSNP
rs1278266984 1703 dbSNP
rs138923906 1705 dbSNP
rs769169741 1709 dbSNP
rs1000517704 1715 dbSNP
rs1290462412 1717 dbSNP
rs886053384 1719 dbSNP
rs1211619860 1723 dbSNP
rs904126534 1729 dbSNP
rs886053383 1732 dbSNP
rs554481437 1733 dbSNP
rs896617891 1744 dbSNP
rs890980801 1745 dbSNP
rs1049665070 1749 dbSNP
rs1338478654 1752 dbSNP
rs997129784 1755 dbSNP
rs1049073936 1759 dbSNP
rs930641698 1765 dbSNP
rs1407434824 1770 dbSNP
rs1402028884 1781 dbSNP
rs1377956806 1787 dbSNP
rs1354406945 1794 dbSNP
rs919876587 1796 dbSNP
rs1177430525 1798 dbSNP
rs903778854 1802 dbSNP
rs1245487190 1803 dbSNP
rs961503528 1818 dbSNP
rs1043386378 1819 dbSNP
rs74943260 1821 dbSNP
rs913636146 1822 dbSNP
rs1270812503 1824 dbSNP
rs559481575 1825 dbSNP
rs1482665987 1827 dbSNP
rs1056256261 1832 dbSNP
rs368769683 1835 dbSNP
rs1218227799 1837 dbSNP
rs1315281332 1839 dbSNP
rs1186489140 1841 dbSNP
rs939528955 1844 dbSNP
rs1473987505 1848 dbSNP
rs986965905 1852 dbSNP
rs1246741724 1853 dbSNP
rs926821931 1856 dbSNP
rs980965294 1857 dbSNP
rs1373748151 1859 dbSNP
rs545706385 1866 dbSNP
rs749721429 1867 dbSNP
rs1342427046 1868 dbSNP
rs1449956400 1878 dbSNP
rs1394139310 1884 dbSNP
rs1378151785 1896 dbSNP
rs1568448 1900 dbSNP
rs886053382 1906 dbSNP
rs967699460 1909 dbSNP
rs962040930 1911 dbSNP
rs1276684926 1913 dbSNP
rs1432501224 1921 dbSNP
rs868650355 1922 dbSNP
rs1256430745 1923 dbSNP
rs770108840 1932 dbSNP
rs1009436719 1948 dbSNP
rs1009783144 1961 dbSNP
rs1247847392 1963 dbSNP
rs953492455 1971 dbSNP
rs1191125673 1980 dbSNP
rs886053381 1987 dbSNP
rs746234262 1988 dbSNP
rs1404649833 1989 dbSNP
rs113905467 1990 dbSNP
rs757488031 1991 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugcgucuCGGGCUUUCGGGGGUCa 5'
                 |||:     ||:|| | 
Target 5' -----cuGCCUCCCCUCCUCCCGu 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugcgucuCGGGCUUUCGGGGGUCa 5'
                 |||:     ||:|| | 
Target 5' -----cuGCCUCCCCUCCUCCCGu 3'
 		1 - 19
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM4903831
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_a
Location of target site NM_173477 | 3UTR | CAGCCCCCAGCAUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000319642.1 | 3UTR | CUGCCUCCCCUCCUCCCGUCCACCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000319642.1 | 3UTR | CUGCCUCCCCUCCUCCCGUCCACCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.639 9.4e-3 -0.555 2.4e-2 13 Click to see details
GSE21849 B cell lymphoma 0.189 1.6e-1 0.126 2.6e-1 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.201 1.7e-1 0.079 3.5e-1 25 Click to see details
GSE17306 Multiple myeloma 0.101 2.4e-1 0.264 3.3e-2 49 Click to see details
GSE32688 Pancreatic cancer 0.095 3.0e-1 0.109 2.8e-1 32 Click to see details
GSE21687 Ependynoma primary tumors 0.065 3.0e-1 0.100 2.2e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.102 3.3e-1 0.032 4.5e-1 20 Click to see details
GSE14794 Lymphoblastoid cells 0.044 3.4e-1 0.017 4.4e-1 90 Click to see details
GSE27834 Pluripotent stem cells 0.09 3.7e-1 -0.003 5.0e-1 16 Click to see details
GSE38226 Liver fibrosis -0.053 4.1e-1 -0.279 1.1e-1 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.039 4.3e-1 0.059 3.9e-1 23 Click to see details
GSE26953 Aortic valvular endothelial cells 0.037 4.3e-1 0.042 4.2e-1 24 Click to see details
GSE28544 Breast cancer -0.031 4.4e-1 -0.012 4.8e-1 24 Click to see details
GSE28544 Breast cancer -0.031 4.4e-1 -0.012 4.8e-1 24 Click to see details
GSE28544 Breast cancer -0.031 4.4e-1 -0.012 4.8e-1 24 Click to see details
GSE28544 Breast cancer -0.031 4.4e-1 -0.012 4.8e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-637 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006147 SP7 Sp7 transcription factor 3 1
MIRT054906 COL4A1 collagen type IV alpha 1 chain 1 1
MIRT159142 NRBP1 nuclear receptor binding protein 1 2 2
MIRT358526 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT441490 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT443472 ACPP acid phosphatase, prostate 2 2
MIRT464631 UBE4A ubiquitination factor E4A 2 2
MIRT465259 TRIM44 tripartite motif containing 44 2 2
MIRT473975 LRRC58 leucine rich repeat containing 58 2 2
MIRT475168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT477631 EFNA1 ephrin A1 2 2
MIRT480100 CALR calreticulin 2 2
MIRT483504 STMN3 stathmin 3 2 4
MIRT483735 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT483847 UNC5B unc-5 netrin receptor B 2 2
MIRT485973 RTBDN retbindin 2 2
MIRT486616 METTL6 methyltransferase like 6 2 2
MIRT487847 CLSTN1 calsyntenin 1 2 4
MIRT488675 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT489046 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT490612 SLC47A1 solute carrier family 47 member 1 2 4
MIRT490990 USP22 ubiquitin specific peptidase 22 2 2
MIRT492559 PRX periaxin 2 2
MIRT494667 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT495880 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT496778 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT499742 USH1G USH1 protein network component sans 2 4
MIRT500371 ZNF385A zinc finger protein 385A 2 2
MIRT503257 KIF18B kinesin family member 18B 2 2
MIRT504511 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT511940 FAM127B retrotransposon Gag like 8A 2 2
MIRT514606 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT527187 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT532494 HOXA13 homeobox A13 2 2
MIRT533504 TRIM71 tripartite motif containing 71 2 2
MIRT539171 AR androgen receptor 2 2
MIRT542735 RBFOX2 RNA binding protein, fox-1 homolog 2 2 2
MIRT544647 PHF8 PHD finger protein 8 2 4
MIRT546232 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 2
MIRT548372 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT555913 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT565381 TGOLN2 trans-golgi network protein 2 2 2
MIRT568954 RUNX3 runt related transcription factor 3 2 2
MIRT570205 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT573599 CERS1 ceramide synthase 1 2 2
MIRT615364 CCNF cyclin F 2 2
MIRT616102 HOXB5 homeobox B5 2 2
MIRT619127 CD40LG CD40 ligand 2 2
MIRT634968 C8orf17 chromosome 8 open reading frame 17 2 2
MIRT646665 FNBP1 formin binding protein 1 2 2
MIRT649633 RASA4 RAS p21 protein activator 4 2 2
MIRT658443 FAM167B family with sequence similarity 167 member B 2 2
MIRT660237 BMP7 bone morphogenetic protein 7 2 2
MIRT669467 ATL3 atlastin GTPase 3 2 2
MIRT670557 SHISA2 shisa family member 2 2 2
MIRT671035 PCDHB2 protocadherin beta 2 2 2
MIRT684255 TBXA2R thromboxane A2 receptor 2 2
MIRT688619 CYBRD1 cytochrome b reductase 1 3 2
MIRT694346 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT695516 ALPI alkaline phosphatase, intestinal 2 2
MIRT697512 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT700133 RNF144B ring finger protein 144B 2 2
MIRT711667 TRMT5 tRNA methyltransferase 5 2 2
MIRT712156 TAOK1 TAO kinase 1 2 2
MIRT712463 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT720759 FAM193A family with sequence similarity 193 member A 2 2
MIRT731198 AKT1 AKT serine/threonine kinase 1 2 1
MIRT755463 PACS2 phosphofurin acidic cluster sorting protein 2 1 1
MIRT755522 FOXM1 forkhead box M1 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-637 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-miR-637 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive Low Squamous Cell Carcinoma cell line (SCC-11)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-637 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Tivantinib 11494412 NSC758242 resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-637 Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, HCT-116)
hsa-miR-637 Sevoflurane 5206 NSC760367 approved sensitive Low Colorectal Cancer cell line
hsa-mir-637 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-637 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-637 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-637 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-637 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-637 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-637 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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