pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PCSK9   
Synonyms FH3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Description proprotein convertase subtilisin/kexin type 9
Transcript NM_174936   
Expression
Putative miRNA Targets on PCSK9
3'UTR of PCSK9
(miRNA target sites are highlighted)
>PCSK9|NM_174936|3'UTR
   1 CAGCCCCATCCCAGGATGGGTGTCTGGGGAGGGTCAAGGGCTGGGGCTGAGCTTTAAAATGGTTCCGACTTGTCCCTCTC
  81 TCAGCCCTCCATGGCCTGGCACGAGGGGATGGGGATGCTTCCGCCTTTCCGGGGCTGCTGGCCTGGCCCTTGAGTGGGGC
 161 AGCCTCCTTGCCTGGAACTCACTCACTCTGGGTGCCTCCTCCCCAGGTGGAGGTGCCAGGAAGCTCCCTCCCTCACTGTG
 241 GGGCATTTCACCATTCAAACAGGTCGAGCTGTGCTCGGGTGCTGCCAGCTGCTCCCAATGTGCCGATGTCCGTGGGCAGA
 321 ATGACTTTTATTGAGCTCTTGTTCCGTGCCAGGCATTCAATCCTCAGGTCTCCACCAAGGAGGCAGGATTCTTCCCATGG
 401 ATAGGGGAGGGGGCGGTAGGGGCTGCAGGGACAAACATCGTTGGGGGGTGAGTGTGAAAGGTGCTGATGGCCCTCATCTC
 481 CAGCTAACTGTGGAGAAGCCCCTGGGGGCTCCCTGATTAATGGAGGCTTAGCTTTCTGGATGGCATCTAGCCAGAGGCTG
 561 GAGACAGGTGCGCCCCTGGTGGTCACAGGCTGTGCCTTGGTTTCCTGAGCCACCTTTACTCTGCTCTATGCCAGGCTGTG
 641 CTAGCAACACCCAAAGGTGGCCTGCGGGGAGCCATCACCTAGGACTGACTCGGCAGTGTGCAGTGGTGCATGCACTGTCT
 721 CAGCCAACCCGCTCCACTACCCGGCAGGGTACACATTCGCACCCCTACTTCACAGAGGAAGAAACCTGGAACCAGAGGGG
 801 GCGTGCCTGCCAAGCTCACACAGCAGGAACTGAGCCAGAAACGCAGATTGGGCTGGCTCTGAAGCCAAGCCTCTTCTTAC
 881 TTCACCCGGCTGGGCTCCTCATTTTTACGGGTAACAGTGAGGCTGGGAAGGGGAACACAGACCAGGAAGCTCGGTGAGTG
 961 ATGGCAGAACGATGCCTGCAGGCATGGAACTTTTTCCGTTATCACCCAGGCCTGATTCACTGGCCTGGCGGAGATGCTTC
1041 TAAGGCATGGTCGGGGGAGAGGGCCAACAACTGTCCCTCCTTGAGCACCAGCCCCACCCAAGCAAGCAGACATTTATCTT
1121 TTGGGTCTGTCCTCTCTGTTGCCTTTTTACAGCCAACTTTTCTAGACCTGTTTTGCTTTTGTAACTTGAAGATATTTATT
1201 CTGGGTTTTGTAGCATTTTTATTAATATGGTGACTTTTTAAAATAAAAACAAACAAACGTTGTCCTAACAAAAAAAAAAA
1281 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucucguuCUG---GGGCAGAGAUUu 5'
                 |||   :|| ||||| | 
Target 5' tggttccGACTTGTCCCTCTCTCAg 3'
60 - 84 119.00 -10.70
2
miRNA  3' ucucguUCUGGGGCAGAGAUUu 5'
                || |  | |:||||: 
Target 5' ttttacAGCCAACTTTTCTAGa 3'
1145 - 1166 116.00 -7.40
3
miRNA  3' ucUCGUUCUGGGGC-----AGAGAUUu 5'
            || ||| |||:|     || ||:| 
Target 5' ggAG-AAGCCCCTGGGGGCTCCCTGAt 3'
492 - 517 111.00 -17.03
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
297710 29 ClinVar
297711 59 ClinVar
265950 76 ClinVar
297712 79 ClinVar
297713 91 ClinVar
297714 123 ClinVar
297715 153 ClinVar
297716 172 ClinVar
873731 180 ClinVar
297717 208 ClinVar
297718 233 ClinVar
297719 235 ClinVar
873732 266 ClinVar
297720 275 ClinVar
874691 277 ClinVar
297721 346 ClinVar
874692 369 ClinVar
297722 405 ClinVar
297723 405 ClinVar
297724 415 ClinVar
297725 427 ClinVar
297726 443 ClinVar
297727 445 ClinVar
297728 465 ClinVar
297729 471 ClinVar
297730 489 ClinVar
297731 510 ClinVar
297732 537 ClinVar
297733 549 ClinVar
297734 572 ClinVar
297735 615 ClinVar
876637 667 ClinVar
297736 760 ClinVar
297737 786 ClinVar
297738 804 ClinVar
873786 844 ClinVar
297739 847 ClinVar
297740 850 ClinVar
988770 864 ClinVar
873787 888 ClinVar
297741 951 ClinVar
988769 981 ClinVar
297742 1053 ClinVar
297743 1086 ClinVar
874742 1094 ClinVar
297744 1151 ClinVar
297745 1155 ClinVar
297746 1169 ClinVar
297747 1230 ClinVar
297748 1247 ClinVar
COSN30470396 15 COSMIC
COSN31536775 48 COSMIC
COSN20073458 131 COSMIC
COSN8474416 274 COSMIC
COSN5373596 396 COSMIC
COSN6460342 572 COSMIC
COSN25765832 680 COSMIC
COSN32057306 872 COSMIC
COSN7224152 1086 COSMIC
COSN23998310 1163 COSMIC
COSN10050369 1241 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1169441514 2 dbSNP
rs1419917238 5 dbSNP
rs1442996382 6 dbSNP
rs768204124 7 dbSNP
rs773818469 9 dbSNP
rs1366938062 15 dbSNP
rs553095640 21 dbSNP
rs1405021769 23 dbSNP
rs1302206576 26 dbSNP
rs189293781 29 dbSNP
rs771949878 30 dbSNP
rs1015416657 38 dbSNP
rs970494615 41 dbSNP
rs1340440495 45 dbSNP
rs773075461 50 dbSNP
rs760320200 51 dbSNP
rs1410050717 58 dbSNP
rs886046437 59 dbSNP
rs1159122739 60 dbSNP
rs962100203 63 dbSNP
rs994959013 67 dbSNP
rs764673359 68 dbSNP
rs28362287 76 dbSNP
rs1403962635 78 dbSNP
rs757944328 79 dbSNP
rs779641062 82 dbSNP
rs1490414204 88 dbSNP
rs549317206 91 dbSNP
rs936619529 103 dbSNP
rs1450296241 108 dbSNP
rs1286923206 114 dbSNP
rs953422561 115 dbSNP
rs989327370 119 dbSNP
rs751118819 123 dbSNP
rs1286548447 124 dbSNP
rs565851054 130 dbSNP
rs912152944 131 dbSNP
rs72646531 132 dbSNP
rs1302838439 134 dbSNP
rs1213804355 135 dbSNP
rs534769041 136 dbSNP
rs557810558 142 dbSNP
rs1346786994 148 dbSNP
rs890219404 150 dbSNP
rs886046438 153 dbSNP
rs988303907 157 dbSNP
rs557622245 172 dbSNP
rs1428146812 175 dbSNP
rs1189141189 187 dbSNP
rs1198998812 191 dbSNP
rs1477223169 202 dbSNP
rs1244220160 207 dbSNP
rs780774423 208 dbSNP
rs1446937027 213 dbSNP
rs898800751 217 dbSNP
rs145330737 233 dbSNP
rs182138201 235 dbSNP
rs1282847200 244 dbSNP
rs187366792 253 dbSNP
rs886644283 259 dbSNP
rs1270561772 263 dbSNP
rs1014422575 265 dbSNP
rs368297335 266 dbSNP
rs937695786 267 dbSNP
rs886046439 275 dbSNP
rs372350423 278 dbSNP
rs1469841199 279 dbSNP
rs1404765851 285 dbSNP
rs1056749858 289 dbSNP
rs1173464893 292 dbSNP
rs769628328 305 dbSNP
rs777645981 306 dbSNP
rs561634446 307 dbSNP
rs980569920 312 dbSNP
rs1367014114 313 dbSNP
rs1033025408 316 dbSNP
rs1439751801 318 dbSNP
rs957586588 330 dbSNP
rs989397020 332 dbSNP
rs1309484550 336 dbSNP
rs1274058525 338 dbSNP
rs1439130943 339 dbSNP
rs1004125446 342 dbSNP
rs17111555 346 dbSNP
rs770857069 347 dbSNP
rs1453319369 353 dbSNP
rs1381332915 363 dbSNP
rs1300577017 368 dbSNP
rs151125363 369 dbSNP
rs911692292 374 dbSNP
rs1169369738 376 dbSNP
rs564160446 381 dbSNP
rs1429475339 388 dbSNP
rs1388739206 395 dbSNP
rs886046440 405 dbSNP
rs1165967560 408 dbSNP
rs1027742048 413 dbSNP
rs953466707 414 dbSNP
rs13376071 415 dbSNP
rs1018994107 416 dbSNP
rs1233643654 426 dbSNP
rs886046441 427 dbSNP
rs966264807 429 dbSNP
rs550300315 431 dbSNP
rs920299564 433 dbSNP
rs1293694184 436 dbSNP
rs563834186 440 dbSNP
rs573180793 441 dbSNP
rs914045128 442 dbSNP
rs1222515081 443 dbSNP
rs72646533 443 dbSNP
rs28362288 445 dbSNP
rs28362289 453 dbSNP
rs979554949 462 dbSNP
rs886046442 465 dbSNP
rs886046443 471 dbSNP
rs886046444 489 dbSNP
rs1180452405 490 dbSNP
rs1368383810 496 dbSNP
rs1014473482 497 dbSNP
rs1380812866 499 dbSNP
rs548989313 501 dbSNP
rs72646534 504 dbSNP
rs886046445 510 dbSNP
rs1408838170 513 dbSNP
rs1181662275 515 dbSNP
rs757196482 517 dbSNP
rs1482202058 519 dbSNP
rs1271407639 526 dbSNP
rs1222935691 532 dbSNP
rs72646535 537 dbSNP
rs772321046 537 dbSNP
rs886046446 549 dbSNP
rs1241134346 552 dbSNP
rs1316935150 555 dbSNP
rs1287174692 571 dbSNP
rs662145 572 dbSNP
rs1346996430 573 dbSNP
rs1033492730 577 dbSNP
rs1405905466 580 dbSNP
rs957428111 584 dbSNP
rs1356970840 585 dbSNP
rs1056131446 593 dbSNP
rs17111557 615 dbSNP
rs1158516051 617 dbSNP
rs1354350207 619 dbSNP
rs1440442645 620 dbSNP
rs551502518 621 dbSNP
rs1334000029 627 dbSNP
rs1200471738 630 dbSNP
rs1432348106 638 dbSNP
rs1378291136 642 dbSNP
rs764587283 645 dbSNP
rs1486154074 648 dbSNP
rs966616937 654 dbSNP
rs571711835 655 dbSNP
rs1358480437 658 dbSNP
rs1229137487 665 dbSNP
rs1330828556 666 dbSNP
rs777232480 666 dbSNP
rs762427407 667 dbSNP
rs911759536 668 dbSNP
rs765744739 674 dbSNP
rs1200264462 676 dbSNP
rs1238787072 677 dbSNP
rs1320535734 679 dbSNP
rs539259897 688 dbSNP
rs1181614039 692 dbSNP
rs974559716 694 dbSNP
rs1465740717 696 dbSNP
rs751077328 697 dbSNP
rs930343330 698 dbSNP
rs1428959332 699 dbSNP
rs1247317753 708 dbSNP
rs889202048 710 dbSNP
rs373867523 714 dbSNP
rs907513439 719 dbSNP
rs1199462488 721 dbSNP
rs950291623 722 dbSNP
rs1252763163 730 dbSNP
rs1018945396 731 dbSNP
rs1452557623 732 dbSNP
rs901858718 733 dbSNP
rs1002102713 738 dbSNP
rs1433558568 739 dbSNP
rs1009801394 740 dbSNP
rs1021222541 742 dbSNP
rs1385006046 743 dbSNP
rs1054595868 746 dbSNP
rs1334927598 750 dbSNP
rs1395589163 754 dbSNP
rs968588765 759 dbSNP
rs886046447 760 dbSNP
rs1034304126 764 dbSNP
rs28362290 765 dbSNP
rs1389352615 775 dbSNP
rs991882624 776 dbSNP
rs879886207 777 dbSNP
rs939691598 779 dbSNP
rs1166585213 784 dbSNP
rs886046448 786 dbSNP
rs113241059 797 dbSNP
rs1220297401 798 dbSNP
rs955364172 803 dbSNP
rs529378080 804 dbSNP
rs1440246792 810 dbSNP
rs1252197284 815 dbSNP
rs931260736 828 dbSNP
rs748386411 830 dbSNP
rs1196052013 831 dbSNP
rs1343261076 836 dbSNP
rs1049560093 840 dbSNP
rs889645684 841 dbSNP
rs943439922 843 dbSNP
rs28362291 844 dbSNP
rs1191839538 845 dbSNP
rs901807760 846 dbSNP
rs886046449 847 dbSNP
rs72646536 849 dbSNP
rs28362292 850 dbSNP
rs1193851604 858 dbSNP
rs951792188 874 dbSNP
rs1469571787 876 dbSNP
rs1171392767 877 dbSNP
rs796694326 881 dbSNP
rs756500786 888 dbSNP
rs1001548344 889 dbSNP
rs981756165 893 dbSNP
rs1182014730 895 dbSNP
rs1033840761 897 dbSNP
rs1249247736 898 dbSNP
rs959823691 909 dbSNP
rs1055053262 910 dbSNP
rs1491002124 912 dbSNP
rs1279029711 913 dbSNP
rs991830322 919 dbSNP
rs1354276920 928 dbSNP
rs893277419 928 dbSNP
rs572111176 939 dbSNP
rs1281361491 944 dbSNP
rs72646537 951 dbSNP
rs1221432308 953 dbSNP
rs1257757440 954 dbSNP
rs1286745567 955 dbSNP
rs541024610 957 dbSNP
rs972367074 964 dbSNP
rs28362293 971 dbSNP
rs577623275 975 dbSNP
rs543667904 982 dbSNP
rs1281534890 989 dbSNP
rs1488963336 990 dbSNP
rs1403551061 996 dbSNP
rs1386411675 998 dbSNP
rs542708704 999 dbSNP
rs943857795 1000 dbSNP
rs1216919919 1001 dbSNP
rs1248867448 1006 dbSNP
rs1267710162 1008 dbSNP
rs1480335113 1009 dbSNP
rs1409278833 1017 dbSNP
rs529445737 1019 dbSNP
rs1197189181 1021 dbSNP
rs1481599797 1024 dbSNP
rs563166632 1030 dbSNP
rs1040451273 1031 dbSNP
rs1478648890 1042 dbSNP
rs1450393051 1048 dbSNP
rs149837083 1053 dbSNP
rs557703061 1053 dbSNP
rs530671596 1054 dbSNP
rs1225610504 1065 dbSNP
rs145806888 1065 dbSNP
rs1367975898 1068 dbSNP
rs528515821 1071 dbSNP
rs886046450 1086 dbSNP
rs1434110731 1088 dbSNP
rs1328112704 1090 dbSNP
rs1299083955 1091 dbSNP
rs1365184974 1092 dbSNP
rs551315846 1098 dbSNP
rs903883328 1102 dbSNP
rs1303155155 1107 dbSNP
rs140641462 1126 dbSNP
rs1178083507 1130 dbSNP
rs1055787609 1131 dbSNP
rs895281187 1136 dbSNP
rs1013698888 1139 dbSNP
rs1277652244 1149 dbSNP
rs563024336 1151 dbSNP
rs1250411955 1154 dbSNP
rs1189811063 1155 dbSNP
rs886046451 1155 dbSNP
rs914767385 1168 dbSNP
rs1025135322 1169 dbSNP
rs377553033 1169 dbSNP
rs886046452 1169 dbSNP
rs1205736159 1177 dbSNP
rs1489710194 1182 dbSNP
rs961091227 1182 dbSNP
rs1217239020 1183 dbSNP
rs1341254105 1191 dbSNP
rs993905489 1192 dbSNP
rs559511576 1193 dbSNP
rs1372513664 1196 dbSNP
rs1269914938 1203 dbSNP
rs778043694 1205 dbSNP
rs1452510013 1206 dbSNP
rs757213359 1229 dbSNP
rs886046453 1230 dbSNP
rs891216315 1235 dbSNP
rs545851832 1238 dbSNP
rs1358196777 1240 dbSNP
rs1040126409 1241 dbSNP
rs1441695964 1243 dbSNP
rs1159316619 1245 dbSNP
rs1169724723 1245 dbSNP
rs1392448444 1245 dbSNP
rs368406783 1247 dbSNP
rs886046454 1247 dbSNP
rs899800571 1247 dbSNP
rs1183655651 1259 dbSNP
rs1237083440 1259 dbSNP
rs778769653 1259 dbSNP
rs745934039 1263 dbSNP
rs1439286943 1265 dbSNP
rs145373574 1265 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            ||::||||||||||||||  
Target 5' acAGUGAGACCCCGUCUCUAu- 3'
4 - 24
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 255738.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 255738.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000302118.5 | 3UTR | CAACAGUGAGACCCCGUCUCUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000302118.5 | 3UTR | GCAACAGUGAGACCCCGUCUCUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000302118.5 | 3UTR | CCUGGGCAACAGUGAGACCCCGUCUCUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000302118.5 | 3UTR | CCUGGGCAACAGUGAGACCCCGUCUCUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000302118.5 | 3UTR | CAACAGUGAGACCCCGUCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000302118.5 | 3UTR | CAACAGUGAGACCCCGUCUCUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000302118.5 | 3UTR | CCUGGGCAACAGUGAGACCCCGUCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.56 2.2e-3 -0.574 1.7e-3 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.468 1.2e-2 0.306 7.8e-2 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.189 1.8e-1 -0.395 2.5e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells -0.167 2.2e-1 -0.260 1.1e-1 24 Click to see details
GSE38226 Liver fibrosis 0.171 2.3e-1 0.204 1.9e-1 21 Click to see details
GSE28260 Renal cortex and medulla -0.173 2.9e-1 -0.236 2.2e-1 13 Click to see details
GSE32688 Pancreatic cancer 0.071 3.5e-1 0.163 1.9e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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