pre-miRNA Information
pre-miRNA hsa-mir-3678   
Genomic Coordinates chr17: 75406069 - 75406162
Description Homo sapiens miR-3678 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3678-3p
Sequence 69| CUGCAGAGUUUGUACGGACCGG |90
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs988363493 1 dbSNP
rs753118178 5 dbSNP
rs1424776090 14 dbSNP
rs1475188526 15 dbSNP
rs1163369708 17 dbSNP
rs1174219930 19 dbSNP
rs915488824 20 dbSNP
rs1273558782 21 dbSNP
rs755095016 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GPX8   
Synonyms EPLA847, GPx-8, GSHPx-8, UNQ847
Description glutathione peroxidase 8 (putative)
Transcript NM_001008397   
Expression
Putative miRNA Targets on GPX8
3'UTR of GPX8
(miRNA target sites are highlighted)
>GPX8|NM_001008397|3'UTR
   1 GAATGCCATTGCGTTTCTAATAGAACAGAGAAATGTCTCCATGAGGGTTTGGTCTCATTTTAAACATTTTTTTTTTGGAG
  81 ACAGTGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTAGTGCGTTCTCAGCTCATTGCAACCTCTGCCTTTTTAAACATG
 161 CTATTAAATGTGGCAATGAAGGATTTTTTTTTAATGTTATCTTGCTATTAAGTGGTAATGAATGTTCCCAGGATGAGGAT
 241 GTTACCCAAAGCAAAAATCAAGAGTAGCCAAAGAATCAACATGAAATATATTAACTACTTCCTCTGACCATACTAAAGAA
 321 TTCAGAATACACAGTGACCAATGTGCCTCAATATCTTATTGTTCAACTTGACATTTTCTAGGACTGTACTTGATGAAAAT
 401 GCCAACACACTAGACCACTCTTTGGATTCAAGAGCACTGTGTATGACTGAAATTTCTGGAATAACTGTAAATGGTTATGT
 481 TAATGGAATAAAACACAAATGTTGAAAAATGTAAAATATATATACATAGATTCAAATCCTTATATATGTATGCTTGTTTT
 561 GTGTACAGGATTTTGTTTTTTCTTTTTAAGTACAGGTTCCTAGTGTTTTACTATAACTGTCACTATGTATGTAACTGACA
 641 TATATAAATAGTCATTTATAAATGACCGTATTATAACATTTGAAAAAGTCTTCATCATTTTCAGTATTTCTCTCTGCATT
 721 ATTTTTTAGAAGCAACTCAAATTCTGTAATCATAATATTACCAAGTAAGTCAGTCTTTATTTTTGCGTGAAAATCCCAAG
 801 TGTAGAAAAAAGGACATGAGTATAAGATCATTTAACTTGATTCCTTATAGGCTGATTTGGGTTGCTAATGTATTCGTACT
 881 AGATTAGCCACTTGGGAGGAATTCAATGCTGCATCATTCTGATAGCTGAAATAGTAAAAGTCAACTCCAAACAGCCTAAA
 961 TTCTAGTATAAAAAGGGGGTGATCATACAAGTCCTAAAGTGTAGATCAGCAGTCACTGAACCTCTTAGAGTCACAAGGCA
1041 TTTCTTCTCCCAAAGTCATGACCTTTATATTTTGTTAGCCTTATAATTGACTAACAAAGCAACCTGCCAAGTTGGTGAAG
1121 GTTAATTATTGCCTCATGAAATATACATTCATCGCATAAAAGAATTAAATAGGAAGATGGCCAAAAATGTAAAAAAGTCG
1201 TATAAATTTGTCTAAGAAGAAAAAGACCCAATTTAAGTAGTCTGTGACTTGACTCCCAAATTCTGACCTGATGGATGAAA
1281 GTGAAGATGTTTCGTATGGCAAATTCAGTAATGCTACCTCAGTATATAGTTCTGTATACGTATTTGGACCAAAGTTATTA
1361 GATAAACCAAAAATATTTCATGAAGCATCTTCTGCTTCAGAGTCCATATCCAGCCACCCAGCTATGAATGTATTTAGAAA
1441 GATATTTGGTGGAGGTGGAATTTCTACCAGAGGTCAAGAGGATTTGTAGGGATAGCCTCAAGAATGCCAGATGAGTGTGT
1521 CAGAAAGCCTGCTCCTACCTCTCGCCAGCTGCGTGACTTTAGGCAAGTCACTTAAGTACCTTATTTCAGTTTCCTCACCT
1601 GTAAATTGAACAGGGGTTGAATGGAATAAAAAGCCCTTTGCAACTCTAAAAGTCAATTAACACACTTACTAAGGTGTTTT
1681 AAGTGACCAGGAAGGAAATCAGAACTAACCTGGATTGTTAGCGAAGAAAACAGAAGCCACCAACAAGCCTATCTGTCCTT
1761 TGCAATTTTGCTCCAAGAGCCTATTAGCAATTTGAATTCTGAGCCTCTAAGAAAACTTATGCTCAGGTGGCCCCTCCAAG
1841 TGTTGGTGCCAGAGCACTCTTGCCTTGTATCCTCACCTACGCCTTCCATGAACTCATAGCAGTGCTGTGGCACTGCAGGG
1921 GTGTTTTATGCATTCACGTTAGGAGCATGAGCAGAACTGCATATGCCAGCACCACATGGGCAGCAGAGACTCCCCACTGC
2001 CAGATGGATGATAATGGAGCTGCACTGGGAACAACCAGGACTGTCCCAGTCAACATGATACAGATGAACATCCTGCCTTA
2081 AGTCACTAGCTCTCTCCAAAGCCAGATAAAGTGGGTTTCTTCACTTACATCTCTCTAATCTTGGCTGCCTTATTCAACCT
2161 ACAGACTCTATGTCAGTGCTGGATTTTCTCCCCTTGCCCTTTAGGTAAGCAGAGTAGGCAGGAGGAGATTTGAAAGCGTG
2241 TCATACATATTGCCTTGAAAGAAAGGACATTCAGGTGTCCCTTCGGGGTTCTGTAACAATTAGGCTATGTGTGCTGAGAG
2321 AGGGAGCGGAGTCATTTGCTGATGTGCTGCTACCTGTAACTCAAATGCCTCATAGGAATACCAGCGGACAAACACATAGA
2401 GGAAAAGTTGAATCTTTCCTATATTGGACAATCTTCCTTCAGTCTTGTTTCTGCATCAAAAAGTCTGGGACACAGAGTGC
2481 TACAGGATGCCTGGGCTAAGGACTGTAACAGAAAAATATCAACATCAGAGCCTGGCACAGTGGCTCACACCGGTAATCCC
2561 AGCACTTTGGGAGGCCGAGGCGGGTGGATCACTTCAGGTCAGGAGTTCGAGACCATCCTGGCCAACATGGTGAAACCCCC
2641 ATCTCTACTAAAAATACAAAAATTAGCCGGGCACGGTGGCACATGCCTGTAATCCCAGCTACCTGGGAGGCTGAGTCAGA
2721 AGAATCACTTGAAAACAGGAGGCTGAGGTTGCAATGAGCCAAGATTGCACCACTGCACTCCAACCTGGGCAACAGAGCGA
2801 GACCCCATCTTAAAGACCCTGTCTCAAAAAAGAGAGAAAAAGAAAAAGAAAAATATCAGGCATCACATGAAAGAGTATTC
2881 AGCTGTCGTTCTTGTGAAAAAGGAAAAGGACAAAATCAAATGCATTTTAACTGTGGTAACTAATTCACTGACTTGAAGTT
2961 TGCTTTGTTTGTTTTCTTTGGTGCGTAGAGAAGAATACTTCATACTAACTCCTGATCATCTTACAGCAGACATAACAACA
3041 GAGTGTTAGAGACTGGAATAAATATGAATTTGGCTGAAATGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggccAGGCAU-GUUUGAGACGUc 5'
              || ||| :   ||||||| 
Target 5' atttTCAGTATTTCTCTCTGCAt 3'
697 - 719 146.00 -11.70
2
miRNA  3' ggCCAGGCAUGUUUGAGACGuc 5'
            | ||  |:||| ||||||  
Target 5' caGCTCATTGCAACCTCTGCct 3'
128 - 149 144.00 -11.90
3
miRNA  3' ggccAGGCAUGU-UUGAGACGUc 5'
              || |||:| |::||||:| 
Target 5' taccTCAGTATATAGTTCTGTAt 3'
1315 - 1337 134.00 -12.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32052985 2 COSMIC
COSN26978001 7 COSMIC
COSN20442693 13 COSMIC
COSN31532789 14 COSMIC
COSN30171722 22 COSMIC
COSN30464671 55 COSMIC
COSN23016616 77 COSMIC
COSN23016617 77 COSMIC
COSN2534998 77 COSMIC
COSN14470592 78 COSMIC
COSN23363335 123 COSMIC
COSN28187429 126 COSMIC
COSN28843329 193 COSMIC
COSN16128290 570 COSMIC
COSN22317782 751 COSMIC
COSN7947212 1349 COSMIC
COSN6922158 1963 COSMIC
COSN9451930 1970 COSMIC
COSN2110679 2001 COSMIC
COSN28581036 2077 COSMIC
COSN21737793 2325 COSMIC
COSN18804666 2403 COSMIC
COSN16245570 2800 COSMIC
COSN21027422 2989 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765785450 1 dbSNP
rs1479520735 7 dbSNP
rs374800679 13 dbSNP
rs1047689 14 dbSNP
rs1414824313 20 dbSNP
rs1335945225 21 dbSNP
rs200917900 22 dbSNP
rs752697463 23 dbSNP
rs1308068900 24 dbSNP
rs1351761921 26 dbSNP
rs1347383559 29 dbSNP
rs758257213 36 dbSNP
rs1275719478 37 dbSNP
rs1274762507 38 dbSNP
rs866026659 40 dbSNP
rs777780543 42 dbSNP
rs751804749 44 dbSNP
rs757448074 46 dbSNP
rs1482829433 51 dbSNP
rs1223870418 54 dbSNP
rs950802917 55 dbSNP
rs946012523 61 dbSNP
rs552883936 67 dbSNP
rs912627350 67 dbSNP
rs942824929 68 dbSNP
rs1407770977 76 dbSNP
rs1403875310 79 dbSNP
rs867607779 80 dbSNP
rs982708102 86 dbSNP
rs1162547830 91 dbSNP
rs1176758565 96 dbSNP
rs1479923554 105 dbSNP
rs1427569266 106 dbSNP
rs144376943 114 dbSNP
rs1401556488 115 dbSNP
rs10059517 121 dbSNP
rs543962988 123 dbSNP
rs980534636 124 dbSNP
rs537524476 129 dbSNP
rs1314912659 143 dbSNP
rs926465758 154 dbSNP
rs1321683688 169 dbSNP
rs1281062426 172 dbSNP
rs1230069533 174 dbSNP
rs1373945983 177 dbSNP
rs556199725 180 dbSNP
rs1023996687 184 dbSNP
rs1439354849 184 dbSNP
rs77476120 185 dbSNP
rs577336301 194 dbSNP
rs781459419 196 dbSNP
rs544565405 197 dbSNP
rs913549187 200 dbSNP
rs1244195476 214 dbSNP
rs1287303279 217 dbSNP
rs945064713 220 dbSNP
rs1356479494 233 dbSNP
rs1051452043 239 dbSNP
rs890685259 244 dbSNP
rs943602809 266 dbSNP
rs1175955717 268 dbSNP
rs1039184673 269 dbSNP
rs1243767256 281 dbSNP
rs1183065745 289 dbSNP
rs1262996375 295 dbSNP
rs899372361 298 dbSNP
rs1034107523 302 dbSNP
rs1438887541 311 dbSNP
rs559722312 314 dbSNP
rs994915516 315 dbSNP
rs957151086 316 dbSNP
rs1182130507 324 dbSNP
rs1283332030 325 dbSNP
rs1048308024 326 dbSNP
rs886540658 334 dbSNP
rs1315134733 337 dbSNP
rs572402446 338 dbSNP
rs377669720 347 dbSNP
rs571317067 347 dbSNP
rs746091459 352 dbSNP
rs769518941 365 dbSNP
rs967351370 368 dbSNP
rs1157397701 370 dbSNP
rs987189434 373 dbSNP
rs1386474496 380 dbSNP
rs1162991401 386 dbSNP
rs1024264286 387 dbSNP
rs1250098106 388 dbSNP
rs1187289478 389 dbSNP
rs1485677872 395 dbSNP
rs970584929 406 dbSNP
rs1186244725 410 dbSNP
rs1002110756 419 dbSNP
rs878869425 425 dbSNP
rs1213465902 433 dbSNP
rs942782578 448 dbSNP
rs373515157 459 dbSNP
rs1244561632 460 dbSNP
rs1356596264 466 dbSNP
rs920014293 479 dbSNP
rs1214740823 495 dbSNP
rs779842727 500 dbSNP
rs1360847914 501 dbSNP
rs1287477145 512 dbSNP
rs1359718675 516 dbSNP
rs1184530422 519 dbSNP
rs931458889 520 dbSNP
rs1366707095 521 dbSNP
rs1304765271 537 dbSNP
rs376118626 547 dbSNP
rs2407932 551 dbSNP
rs1428139050 554 dbSNP
rs913612279 558 dbSNP
rs146438904 576 dbSNP
rs1184539839 577 dbSNP
rs1490791402 577 dbSNP
rs1269376382 578 dbSNP
rs966502644 583 dbSNP
rs879192992 603 dbSNP
rs1489844463 614 dbSNP
rs1045802070 618 dbSNP
rs768691711 641 dbSNP
rs1379752004 650 dbSNP
rs773725442 651 dbSNP
rs906834057 665 dbSNP
rs550120827 668 dbSNP
rs1034074654 669 dbSNP
rs1403575979 670 dbSNP
rs1399264862 677 dbSNP
rs761455533 688 dbSNP
rs565336802 690 dbSNP
rs1461589230 691 dbSNP
rs1352952241 703 dbSNP
rs892903412 704 dbSNP
rs1011400525 707 dbSNP
rs943591416 708 dbSNP
rs1198432395 712 dbSNP
rs771490473 714 dbSNP
rs772943677 718 dbSNP
rs1252648965 719 dbSNP
rs1313112200 720 dbSNP
rs1020142093 723 dbSNP
rs1212715042 733 dbSNP
rs1249144327 740 dbSNP
rs1257338038 744 dbSNP
rs1205115256 760 dbSNP
rs1323825757 762 dbSNP
rs1262836304 768 dbSNP
rs1039328829 770 dbSNP
rs1482074617 775 dbSNP
rs967698888 777 dbSNP
rs532653168 778 dbSNP
rs920750338 786 dbSNP
rs1371216470 787 dbSNP
rs760427905 788 dbSNP
rs1407205572 789 dbSNP
rs975403026 789 dbSNP
rs1047912804 798 dbSNP
rs919983421 806 dbSNP
rs1433502531 810 dbSNP
rs1365433207 813 dbSNP
rs1182382955 814 dbSNP
rs1418453626 818 dbSNP
rs1247731329 827 dbSNP
rs1184907392 828 dbSNP
rs77377577 843 dbSNP
rs1357574571 844 dbSNP
rs983352092 855 dbSNP
rs1353240675 858 dbSNP
rs1465785462 860 dbSNP
rs1014350334 863 dbSNP
rs1045701306 873 dbSNP
rs566117734 876 dbSNP
rs1317255022 877 dbSNP
rs1453551799 884 dbSNP
rs1002058121 905 dbSNP
rs1335012372 907 dbSNP
rs1033586246 912 dbSNP
rs1046604522 916 dbSNP
rs1332105573 923 dbSNP
rs1158944309 947 dbSNP
rs957992730 950 dbSNP
rs1378477208 952 dbSNP
rs905460469 958 dbSNP
rs936960844 963 dbSNP
rs1444759375 967 dbSNP
rs1011131673 980 dbSNP
rs1460207474 1008 dbSNP
rs1402602926 1009 dbSNP
rs1444700191 1010 dbSNP
rs1242024434 1011 dbSNP
rs533828123 1013 dbSNP
rs1309113057 1016 dbSNP
rs766076353 1017 dbSNP
rs1368937361 1018 dbSNP
rs1221229486 1020 dbSNP
rs1299728549 1021 dbSNP
rs753553887 1021 dbSNP
rs1310060589 1025 dbSNP
rs1204987004 1027 dbSNP
rs1262789606 1027 dbSNP
rs753153188 1029 dbSNP
rs1258106565 1030 dbSNP
rs1020786935 1031 dbSNP
rs1458684696 1033 dbSNP
rs966827214 1034 dbSNP
rs562136263 1040 dbSNP
rs1196231033 1048 dbSNP
rs987250846 1050 dbSNP
rs1020531291 1058 dbSNP
rs1488767476 1077 dbSNP
rs911555883 1104 dbSNP
rs1318721399 1111 dbSNP
rs964405363 1116 dbSNP
rs763345685 1124 dbSNP
rs1192701021 1137 dbSNP
rs1422866573 1140 dbSNP
rs974419796 1145 dbSNP
rs1480218030 1152 dbSNP
rs764719662 1154 dbSNP
rs751585333 1155 dbSNP
rs1160956749 1165 dbSNP
rs1048328666 1180 dbSNP
rs1373354867 1191 dbSNP
rs908069597 1192 dbSNP
rs1464079144 1197 dbSNP
rs757293056 1201 dbSNP
rs950175933 1211 dbSNP
rs1045816836 1213 dbSNP
rs549290554 1223 dbSNP
rs1350972557 1225 dbSNP
rs1439292325 1228 dbSNP
rs963943834 1231 dbSNP
rs1197664548 1249 dbSNP
rs1340303580 1251 dbSNP
rs536347185 1259 dbSNP
rs1292126283 1260 dbSNP
rs1269872091 1269 dbSNP
rs182327441 1273 dbSNP
rs937312427 1275 dbSNP
rs1284974940 1280 dbSNP
rs538013239 1287 dbSNP
rs1364961221 1289 dbSNP
rs975373304 1294 dbSNP
rs187409767 1295 dbSNP
rs952790335 1298 dbSNP
rs1166914270 1299 dbSNP
rs1010830457 1303 dbSNP
rs750592577 1306 dbSNP
rs1216176235 1308 dbSNP
rs1200604881 1318 dbSNP
rs1480393225 1323 dbSNP
rs902382294 1325 dbSNP
rs1184052809 1327 dbSNP
rs577273036 1328 dbSNP
rs141097109 1330 dbSNP
rs1272407047 1336 dbSNP
rs1196922751 1337 dbSNP
rs756356113 1340 dbSNP
rs964478056 1341 dbSNP
rs1344783499 1346 dbSNP
rs189016851 1359 dbSNP
rs571743480 1366 dbSNP
rs982698877 1379 dbSNP
rs542280126 1380 dbSNP
rs1490112456 1382 dbSNP
rs1027330663 1388 dbSNP
rs1194137617 1391 dbSNP
rs1461305668 1420 dbSNP
rs1407928771 1422 dbSNP
rs952388521 1423 dbSNP
rs180924842 1432 dbSNP
rs1477003570 1443 dbSNP
rs1167397516 1450 dbSNP
rs1160747376 1453 dbSNP
rs908018160 1455 dbSNP
rs561593018 1460 dbSNP
rs1232309652 1461 dbSNP
rs1176924576 1479 dbSNP
rs185586413 1482 dbSNP
rs1407547118 1488 dbSNP
rs950247041 1493 dbSNP
rs981588073 1511 dbSNP
rs927358273 1513 dbSNP
rs1204030070 1517 dbSNP
rs1311348246 1529 dbSNP
rs1276267714 1530 dbSNP
rs138949806 1534 dbSNP
rs10054014 1539 dbSNP
rs1278439844 1540 dbSNP
rs1444008931 1544 dbSNP
rs902950256 1545 dbSNP
rs1008032644 1547 dbSNP
rs893167443 1553 dbSNP
rs946621795 1554 dbSNP
rs1161743293 1556 dbSNP
rs1401793885 1566 dbSNP
rs1407971170 1574 dbSNP
rs1156911080 1575 dbSNP
rs899743054 1576 dbSNP
rs758342638 1577 dbSNP
rs1385979363 1583 dbSNP
rs1042329244 1597 dbSNP
rs1356482251 1599 dbSNP
rs915049164 1607 dbSNP
rs77905858 1611 dbSNP
rs1217766943 1612 dbSNP
rs1447502262 1620 dbSNP
rs1285284437 1623 dbSNP
rs952675792 1634 dbSNP
rs1018794816 1643 dbSNP
rs1360914804 1662 dbSNP
rs1315155125 1670 dbSNP
rs532640838 1672 dbSNP
rs1004639177 1674 dbSNP
rs1217062991 1683 dbSNP
rs560858700 1692 dbSNP
rs771661014 1695 dbSNP
rs1487419162 1710 dbSNP
rs951769796 1723 dbSNP
rs78932953 1724 dbSNP
rs1015147024 1727 dbSNP
rs1473790093 1751 dbSNP
rs959604878 1756 dbSNP
rs971640284 1761 dbSNP
rs1422282844 1766 dbSNP
rs1421993929 1771 dbSNP
rs981535896 1781 dbSNP
rs927472787 1784 dbSNP
rs1188024791 1795 dbSNP
rs1475642353 1805 dbSNP
rs1180205220 1816 dbSNP
rs1214286515 1818 dbSNP
rs1490821373 1822 dbSNP
rs989699531 1825 dbSNP
rs1220259333 1832 dbSNP
rs190346779 1857 dbSNP
rs915501536 1862 dbSNP
rs1214824484 1876 dbSNP
rs947050179 1881 dbSNP
rs772881922 1882 dbSNP
rs937416869 1887 dbSNP
rs990288760 1889 dbSNP
rs1366813246 1898 dbSNP
rs1293005513 1900 dbSNP
rs1456500587 1901 dbSNP
rs559758238 1906 dbSNP
rs924373115 1908 dbSNP
rs528127507 1921 dbSNP
rs1171348885 1933 dbSNP
rs760372889 1935 dbSNP
rs372361181 1938 dbSNP
rs923816618 1939 dbSNP
rs1191320162 1941 dbSNP
rs3747725 1945 dbSNP
rs1040223847 1948 dbSNP
rs996637405 1953 dbSNP
rs1340715342 1962 dbSNP
rs1487193828 1963 dbSNP
rs115997273 1967 dbSNP
rs888372176 1971 dbSNP
rs1316931146 1974 dbSNP
rs1256557381 1978 dbSNP
rs996311384 1979 dbSNP
rs775984104 1982 dbSNP
rs1048833946 1992 dbSNP
rs531513804 1994 dbSNP
rs1312368267 1996 dbSNP
rs1385624775 1999 dbSNP
rs1381930767 2014 dbSNP
rs887535838 2024 dbSNP
rs1298824332 2026 dbSNP
rs1446318867 2033 dbSNP
rs148920190 2036 dbSNP
rs571149771 2037 dbSNP
rs1168241784 2046 dbSNP
rs1470855329 2050 dbSNP
rs1429772638 2052 dbSNP
rs1175208015 2053 dbSNP
rs1431378345 2054 dbSNP
rs1016032890 2056 dbSNP
rs970833336 2057 dbSNP
rs538330988 2058 dbSNP
rs1351183823 2061 dbSNP
rs1236036558 2065 dbSNP
rs371857205 2066 dbSNP
rs1033773340 2068 dbSNP
rs959490109 2091 dbSNP
rs1444345930 2094 dbSNP
rs1231637488 2097 dbSNP
rs989668357 2112 dbSNP
rs1307778352 2114 dbSNP
rs553421882 2116 dbSNP
rs571944776 2124 dbSNP
rs971586607 2130 dbSNP
rs565453107 2131 dbSNP
rs1402567713 2136 dbSNP
rs977098141 2141 dbSNP
rs924312853 2149 dbSNP
rs1379032127 2150 dbSNP
rs1365526114 2153 dbSNP
rs1469898623 2154 dbSNP
rs1377982810 2163 dbSNP
rs1438585067 2163 dbSNP
rs1034474913 2164 dbSNP
rs958886022 2167 dbSNP
rs181540054 2171 dbSNP
rs990624994 2172 dbSNP
rs914640308 2174 dbSNP
rs943724770 2183 dbSNP
rs1487123336 2184 dbSNP
rs1040729995 2191 dbSNP
rs554269617 2192 dbSNP
rs932458188 2196 dbSNP
rs576668663 2211 dbSNP
rs1246895611 2215 dbSNP
rs1415880939 2221 dbSNP
rs752044192 2223 dbSNP
rs888349043 2225 dbSNP
rs762246876 2230 dbSNP
rs1298691240 2231 dbSNP
rs1404772819 2233 dbSNP
rs1358008243 2238 dbSNP
rs147041984 2239 dbSNP
rs767541344 2242 dbSNP
rs1472913917 2243 dbSNP
rs1367580321 2247 dbSNP
rs906495080 2251 dbSNP
rs1430621564 2262 dbSNP
rs931804632 2263 dbSNP
rs559176259 2270 dbSNP
rs577538828 2271 dbSNP
rs1049384943 2275 dbSNP
rs1237974516 2276 dbSNP
rs1355885123 2279 dbSNP
rs1386110112 2282 dbSNP
rs1229928373 2285 dbSNP
rs887495637 2285 dbSNP
rs1347378226 2286 dbSNP
rs541670107 2300 dbSNP
rs1399250343 2302 dbSNP
rs1022909967 2304 dbSNP
rs966985413 2306 dbSNP
rs367928244 2307 dbSNP
rs1389425188 2310 dbSNP
rs906914872 2314 dbSNP
rs766658493 2316 dbSNP
rs1463210189 2325 dbSNP
rs1358114316 2326 dbSNP
rs1200620574 2328 dbSNP
rs754013351 2329 dbSNP
rs1437833183 2340 dbSNP
rs965393043 2365 dbSNP
rs754747877 2372 dbSNP
rs1034591978 2376 dbSNP
rs1451072075 2385 dbSNP
rs958967899 2386 dbSNP
rs551115795 2387 dbSNP
rs1379781957 2409 dbSNP
rs1011708196 2412 dbSNP
rs932424091 2422 dbSNP
rs909739949 2424 dbSNP
rs939878863 2425 dbSNP
rs1173766864 2428 dbSNP
rs906471504 2429 dbSNP
rs35686230 2435 dbSNP
rs967482668 2442 dbSNP
rs748080150 2447 dbSNP
rs1055159195 2463 dbSNP
rs375001817 2465 dbSNP
rs1390806470 2469 dbSNP
rs1477997184 2475 dbSNP
rs912548754 2479 dbSNP
rs1323939122 2489 dbSNP
rs1458364557 2493 dbSNP
rs1237845197 2494 dbSNP
rs1197017081 2507 dbSNP
rs1456240970 2510 dbSNP
rs1332646529 2512 dbSNP
rs1402902308 2519 dbSNP
rs542162230 2523 dbSNP
rs563580320 2527 dbSNP
rs1282825945 2529 dbSNP
rs1272556192 2539 dbSNP
rs921821884 2544 dbSNP
rs931893399 2545 dbSNP
rs531626522 2552 dbSNP
rs909072831 2553 dbSNP
rs940447955 2564 dbSNP
rs1011035372 2569 dbSNP
rs1335282330 2570 dbSNP
rs1339283026 2576 dbSNP
rs1423754924 2577 dbSNP
rs1160341496 2578 dbSNP
rs1036092557 2582 dbSNP
rs906864182 2583 dbSNP
rs138373093 2585 dbSNP
rs1199164328 2598 dbSNP
rs1267649305 2600 dbSNP
rs1055392551 2610 dbSNP
rs1210622362 2613 dbSNP
rs1441750749 2617 dbSNP
rs1172175014 2618 dbSNP
rs894693801 2623 dbSNP
rs1218747582 2629 dbSNP
rs1307917474 2637 dbSNP
rs999716958 2646 dbSNP
rs1285142899 2649 dbSNP
rs1447811323 2651 dbSNP
rs1019586266 2659 dbSNP
rs966295309 2664 dbSNP
rs1420851266 2666 dbSNP
rs749588596 2668 dbSNP
rs1461390033 2669 dbSNP
rs1327274792 2670 dbSNP
rs1027982969 2676 dbSNP
rs1182205609 2680 dbSNP
rs1021793161 2685 dbSNP
rs1229659217 2690 dbSNP
rs953786557 2693 dbSNP
rs12653368 2704 dbSNP
rs1235549511 2716 dbSNP
rs998927873 2731 dbSNP
rs1488579639 2742 dbSNP
rs1284682166 2747 dbSNP
rs1213901048 2749 dbSNP
rs1402804664 2753 dbSNP
rs1019682373 2755 dbSNP
rs939828440 2758 dbSNP
rs770702643 2763 dbSNP
rs1377354943 2766 dbSNP
rs147402057 2768 dbSNP
rs1401133451 2769 dbSNP
rs1340507630 2777 dbSNP
rs1296393805 2787 dbSNP
rs1426672421 2789 dbSNP
rs547198310 2792 dbSNP
rs776279367 2796 dbSNP
rs745520180 2799 dbSNP
rs560717928 2800 dbSNP
rs186939952 2804 dbSNP
rs1357928883 2808 dbSNP
rs909025778 2810 dbSNP
rs1055128692 2817 dbSNP
rs1262449269 2819 dbSNP
rs1191454280 2820 dbSNP
rs916619326 2825 dbSNP
rs1246798655 2826 dbSNP
rs940547085 2828 dbSNP
rs1319618384 2833 dbSNP
rs971882771 2833 dbSNP
rs1260378187 2835 dbSNP
rs928349591 2850 dbSNP
rs1317808684 2853 dbSNP
rs1488400166 2865 dbSNP
rs938444634 2870 dbSNP
rs1368329216 2888 dbSNP
rs12657420 2889 dbSNP
rs1427355616 2890 dbSNP
rs1187653101 2892 dbSNP
rs35378535 2897 dbSNP
rs554538197 2898 dbSNP
rs774607635 2917 dbSNP
rs1465983041 2921 dbSNP
rs762346225 2941 dbSNP
rs947645410 2947 dbSNP
rs768057268 2952 dbSNP
rs1162676653 2958 dbSNP
rs1360980052 2959 dbSNP
rs773278697 2985 dbSNP
rs192277517 2986 dbSNP
rs1190184582 2989 dbSNP
rs1487286894 3001 dbSNP
rs999001460 3002 dbSNP
rs1019795625 3003 dbSNP
rs1457562455 3008 dbSNP
rs1256578833 3034 dbSNP
rs1235987691 3043 dbSNP
rs901223664 3077 dbSNP
rs533959693 3078 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ggccAGGCAU-GUUUGAGACguc 5'
              || ||| :   |||||   
Target 5' auuuUCAGUAUUUCUCUCUG--- 3'
9 - 28
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000296734.6 | 3UTR | UCUUCAUCAUUUUCAGUAUUUCUCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.504 0.08 -0.667 0.02 9 Click to see details
HNSC -0.138 0.34 -0.255 0.22 11 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
LUSC 0.228 0.39 0.400 0.3 4 Click to see details
86 hsa-miR-3678-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074327 TNRC6A trinucleotide repeat containing 6A 2 10
MIRT107705 CLTA clathrin light chain A 2 2
MIRT114113 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT155293 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT159171 NRBP1 nuclear receptor binding protein 1 2 2
MIRT185795 ZNF678 zinc finger protein 678 2 2
MIRT282672 SYNM synemin 2 2
MIRT294386 ZNF264 zinc finger protein 264 2 2
MIRT295818 CHMP4B charged multivesicular body protein 4B 2 2
MIRT332777 CAPRIN1 cell cycle associated protein 1 2 4
MIRT334112 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT340971 IPO5 importin 5 2 2
MIRT354679 CDV3 CDV3 homolog 2 2
MIRT366662 PLP2 proteolipid protein 2 2 2
MIRT404272 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT447536 RNF165 ring finger protein 165 2 2
MIRT449139 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT451301 LGALS3BP galectin 3 binding protein 2 2
MIRT451488 FOPNL FGFR1OP N-terminal like 2 2
MIRT455198 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT459215 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT461764 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT463273 ZFX zinc finger protein, X-linked 2 2
MIRT464862 UBB ubiquitin B 2 8
MIRT464950 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT467378 SON SON DNA binding protein 2 4
MIRT469282 RHOA ras homolog family member A 2 2
MIRT470293 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT470639 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT477163 FABP3 fatty acid binding protein 3 2 2
MIRT477686 EFHD2 EF-hand domain family member D2 2 2
MIRT479725 CCNF cyclin F 2 2
MIRT481726 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT485673 CCDC64 BICD family like cargo adaptor 1 2 2
MIRT498280 PADI2 peptidyl arginine deiminase 2 2 2
MIRT499921 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT503616 SLC25A36 solute carrier family 25 member 36 2 4
MIRT506927 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507348 FAM129A family with sequence similarity 129 member A 2 6
MIRT508265 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT508284 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT509353 COPS8 COP9 signalosome subunit 8 2 2
MIRT510892 RAB1A RAB1A, member RAS oncogene family 2 4
MIRT511882 GAS1 growth arrest specific 1 2 6
MIRT511990 E2F1 E2F transcription factor 1 2 4
MIRT512239 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512392 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 4
MIRT514086 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT514358 UBBP4 ubiquitin B pseudogene 4 2 6
MIRT523149 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT525511 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT526333 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT529962 ZNF71 zinc finger protein 71 2 2
MIRT530337 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT530884 PHOX2A paired like homeobox 2a 2 2
MIRT533097 YOD1 YOD1 deubiquitinase 2 2
MIRT533250 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT534786 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT537917 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT547799 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT548714 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT555509 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555984 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT557942 FAM222B family with sequence similarity 222 member B 2 2
MIRT560830 ZNF786 zinc finger protein 786 2 2
MIRT562720 ZNF714 zinc finger protein 714 2 2
MIRT565337 TMEM104 transmembrane protein 104 2 2
MIRT614453 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT639474 SLC6A4 solute carrier family 6 member 4 2 2
MIRT644056 IQCE IQ motif containing E 2 2
MIRT651652 VWA1 von Willebrand factor A domain containing 1 2 2
MIRT651866 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT653490 SLC43A2 solute carrier family 43 member 2 2 2
MIRT657039 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT657985 GAN gigaxonin 2 2
MIRT672117 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT683583 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT688689 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT695375 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT696351 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT700614 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 2 2
MIRT703512 FKBP15 FK506 binding protein 15 2 2
MIRT705051 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705180 BTG1 BTG anti-proliferation factor 1 2 2
MIRT709409 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT721053 DCC DCC netrin 1 receptor 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3678-3p Platinum 23939 resistant tissue
hsa-miR-3678-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3678-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3678-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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