miRTarBase - #MIRT500272


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pre-miRNA Information
pre-miRNA hsa-mir-6867   
Genomic Coordinates chr17: 40193597 - 40193663
Description Homo sapiens miR-6867 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6867-3p
Sequence 47| CUCUCCCUCUUUACCCACUAG |67
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM7811173 21 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1403216522 1 dbSNP
rs781776276 3 dbSNP
rs202050374 4 dbSNP
rs367842831 5 dbSNP
rs1223489976 6 dbSNP
rs907256096 9 dbSNP
rs753257137 14 dbSNP
rs757843554 17 dbSNP
rs371369162 18 dbSNP
Putative Targets

Gene Information
Gene Symbol ZNF781   
Synonyms -
Description zinc finger protein 781
Transcript NM_152605   
Expression
Putative miRNA Targets on ZNF781
3'UTR of ZNF781
(miRNA target sites are highlighted)		 
>ZNF781|NM_152605|3'UTR
   1 TGAGACATCAGAGAATTCACAGTGGGGAGAAACCCTATGAATGTAATGAATGTGGGAATGCCTTCATTTGTTTTTTTGAT
  81 TTTAATAGACATCAGAGAATTCACAAAGGAGAGAAACCCTATCAGTGTAAAGAATGTGGGAAGGTTTTTAATAATTATCC
 161 AACTCTTACTCAACATCAAAGAATTCATACCAGTGTGAAACCCTATGAATGTAAGGAATGTGTAAAGACCTTTACTTGGC
 241 TTTCAAACTTGAATAAACATCAGACAATTCACACTGGTGACAAACCCTATGAATGTAAAGATTGTAAAAAAGCTTTTCTT
 321 TGTTATTCAACATTTATTCAACACTATAGAACTCATACTAATGAGAAACCTATGAATGTCAGGAATGCAGCAAGGCCTTT
 401 AAGCAGAGAGCCCATCTTAGTCAACATCAAAATATTCATACTGGTGAGAAACCCTATGAGTTTAAGGAATGTGGGAAGGC
 481 CTTTGCTTGTTTCCTACCTTAATAGAAATCAGAGAATTCACACTAGTGAGAAACCGTATCAGTGTAAAAAATGTAGAAAA
 561 TCCTTTATTGATTGTTCAACTCTTAACACCAGAGAATTCACACTGGTGAGAAACCCTTTGAATGTCAGGAATGTAGGAAG
 641 GCCTTTAGGCAGAGGGCGCATCTTACTCAACATCAAAGAATTCCTACTGGTGAGAAACCCTATGAATGTAATGAATGTGA
 721 GAAGGCCTCTTCTTGTCTTTCATAGGTGAAAAAGCACCAGAGAATACATACATGAAGGGACAAATCTTATGTATTTGAAT
 801 AGCGTCTTTTTATTTAACAATCCTTATCTAACATCACCAAATTCACATTGCAGAGAAACTTCAGAAATATAAGAAATGTG
 881 GGAAACACTTTTACCTGTCCCTCAGCTATACTTTTTCATAACAGAATTTGTACAGGTGAGAAGCCTAATGAAAGCCCGAT
 961 ATGTGTAAAGATCTACTCTCACAATATACTCAACATTATATAATGTATAGTGTGATTAATATAGGAAATCCTTGATTTTG
1041 AAATTATCAATTATGGAATAGCAAACAATTTGTAAGTGAAGAAAATCCAGTGACTGTAAATTTTTTTACCTCATAATTCA
1121 CAATTTATTAAGCATCAGAATTTATATGGAAAAAATAGAATATCAATTATTAATAAAAACATTACCACTAAAATTTTATT
1201 TGACTTATAGAGAATAGCATATAGAGAATAATCATGTTGACTTTGTGAATGTAGAAAAGCTTTTATCTATTACACGAATC
1281 TTTTTCAGCATCATTATACTTTCACCAGTTTCCACGTCTGTTTTATTACCAAGTAATTTAAACTGTATACTTCAGATTAC
1361 AAATTTCTTACATTGTGATAAGGTTATTGTGAAGATTAAATGAGTTTATCCAAAGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaUCACCCA--UUUC-UCCCUCUc 5'
            || |  |  | || :|||||| 
Target 5' tcAGAGAATTCACAGTGGGGAGAa 3'
 8 - 31 129.00 -9.40
2 
miRNA  3' gauCACCCAUUUC-----UCCCUCUc 5'
             || || ||:|     ||| ||| 
Target 5' aatGTAGG-AAGGCCTTTAGGCAGAg 3'
 630 - 654 117.00 -13.00
3 
miRNA  3' gaUCACCCA--UUUCUCC-CUCUc 5'
            || |  |  | | ||| |||| 
Target 5' tcAGAGAATTCACAAAGGAGAGAa 3'
 92 - 115 113.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31586064 2 COSMIC
COSN27006558 4 COSMIC
COSN30123558 13 COSMIC
COSN31497657 13 COSMIC
COSN31508295 27 COSMIC
COSN17038393 33 COSMIC
COSN30481283 33 COSMIC
COSN30180742 43 COSMIC
COSN30158841 62 COSMIC
COSN30156574 65 COSMIC
COSN1215135 70 COSMIC
COSN21219636 84 COSMIC
COSN31573783 88 COSMIC
COSN31601513 108 COSMIC
COSN1215133 120 COSMIC
COSN30127614 123 COSMIC
COSN32053361 123 COSMIC
COSN30127619 125 COSMIC
COSN31573999 132 COSMIC
COSN31583677 132 COSMIC
COSN30181810 138 COSMIC
COSN30522005 139 COSMIC
COSN4778141 160 COSMIC
COSN31558012 181 COSMIC
COSN31609928 181 COSMIC
COSN30177111 227 COSMIC
COSN31583500 349 COSMIC
COSN9356691 428 COSMIC
COSN8343873 475 COSMIC
COSN31585814 530 COSMIC
COSN6668526 536 COSMIC
COSN30537759 545 COSMIC
COSN20079379 579 COSMIC
COSN31490475 626 COSMIC
COSN31611439 656 COSMIC
COSN18742383 657 COSMIC
COSN13801887 658 COSMIC
COSN31582216 678 COSMIC
COSN30132719 712 COSMIC
COSN31585603 713 COSMIC
COSN31525536 762 COSMIC
COSN31539545 767 COSMIC
COSN31598072 804 COSMIC
COSN6143834 819 COSMIC
COSN25718319 894 COSMIC
COSN9356690 894 COSMIC
COSN8260165 996 COSMIC
COSN32056658 1035 COSMIC
COSN9356689 1275 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs947540967 1 dbSNP
rs756362885 9 dbSNP
rs750642668 10 dbSNP
rs1208829635 11 dbSNP
rs767900182 12 dbSNP
rs757410189 14 dbSNP
rs916157180 15 dbSNP
rs1037782914 22 dbSNP
rs765356564 22 dbSNP
rs534388221 24 dbSNP
rs1351372293 26 dbSNP
rs192732259 27 dbSNP
rs1203051254 29 dbSNP
rs1448459671 33 dbSNP
rs908138449 33 dbSNP
rs1317730578 36 dbSNP
rs753068595 36 dbSNP
rs1279214269 37 dbSNP
rs1432535408 40 dbSNP
rs765557416 43 dbSNP
rs1401339056 45 dbSNP
rs78471562 59 dbSNP
rs759946669 60 dbSNP
rs1419694572 67 dbSNP
rs1406409272 71 dbSNP
rs754991033 78 dbSNP
rs771774291 78 dbSNP
rs922099593 78 dbSNP
rs761242341 85 dbSNP
rs773744138 86 dbSNP
rs573907040 91 dbSNP
rs768585666 91 dbSNP
rs749213360 92 dbSNP
rs551509823 94 dbSNP
rs1489379699 95 dbSNP
rs1264043441 100 dbSNP
rs769688876 103 dbSNP
rs745715411 108 dbSNP
rs1291865418 113 dbSNP
rs781499289 121 dbSNP
rs757566430 122 dbSNP
rs751611408 125 dbSNP
rs777748438 126 dbSNP
rs928664809 129 dbSNP
rs972028028 133 dbSNP
rs1237363979 140 dbSNP
rs978513680 141 dbSNP
rs966715572 148 dbSNP
rs539493080 169 dbSNP
rs1016277529 173 dbSNP
rs1289035387 173 dbSNP
rs568781703 182 dbSNP
rs748058290 194 dbSNP
rs1284516941 210 dbSNP
rs1417179346 219 dbSNP
rs895693505 230 dbSNP
rs1364091239 235 dbSNP
rs953202796 240 dbSNP
rs1034189095 244 dbSNP
rs1001344216 245 dbSNP
rs376745629 251 dbSNP
rs1363842357 253 dbSNP
rs1426658268 260 dbSNP
rs1029235381 261 dbSNP
rs1037432633 265 dbSNP
rs997481451 266 dbSNP
rs940374974 293 dbSNP
rs886093814 302 dbSNP
rs1052005701 318 dbSNP
rs112383861 318 dbSNP
rs933575840 331 dbSNP
rs1312428373 336 dbSNP
rs1361098564 347 dbSNP
rs187702711 348 dbSNP
rs1356670796 352 dbSNP
rs529207090 375 dbSNP
rs182306572 381 dbSNP
rs936829087 386 dbSNP
rs1362886456 387 dbSNP
rs1183265394 407 dbSNP
rs1383642266 408 dbSNP
rs1446610785 419 dbSNP
rs1164301373 420 dbSNP
rs1372576432 432 dbSNP
rs1460972019 433 dbSNP
rs903608317 434 dbSNP
rs1300396741 438 dbSNP
rs1397713698 444 dbSNP
rs925380548 445 dbSNP
rs1043462071 452 dbSNP
rs146608229 453 dbSNP
rs1384556628 454 dbSNP
rs1452824096 456 dbSNP
rs1294313564 458 dbSNP
rs1305242390 460 dbSNP
rs1229584320 462 dbSNP
rs10416760 466 dbSNP
rs1237115913 468 dbSNP
rs1251786410 472 dbSNP
rs894683927 474 dbSNP
rs778968344 488 dbSNP
rs768332374 494 dbSNP
rs1462877562 497 dbSNP
rs1411671762 503 dbSNP
rs938977219 511 dbSNP
rs143564880 516 dbSNP
rs377702153 516 dbSNP
rs1475462678 523 dbSNP
rs992122284 526 dbSNP
rs2927747 536 dbSNP
rs1172565776 538 dbSNP
rs10416564 542 dbSNP
rs1489132624 568 dbSNP
rs972055921 570 dbSNP
rs1034241522 574 dbSNP
rs1001793502 576 dbSNP
rs779727892 580 dbSNP
rs909306703 582 dbSNP
rs1242543285 584 dbSNP
rs1359306315 586 dbSNP
rs563899304 592 dbSNP
rs1016456763 611 dbSNP
rs1004629233 615 dbSNP
rs984926153 618 dbSNP
rs1264835056 630 dbSNP
rs1323960017 634 dbSNP
rs1211131393 637 dbSNP
rs1260389204 648 dbSNP
rs1484990427 654 dbSNP
rs190033195 655 dbSNP
rs545105421 656 dbSNP
rs8108261 657 dbSNP
rs187852316 658 dbSNP
rs965970969 659 dbSNP
rs1233345526 670 dbSNP
rs997110470 672 dbSNP
rs1039267671 686 dbSNP
rs1289009943 700 dbSNP
rs1364390920 705 dbSNP
rs1403077621 713 dbSNP
rs1285078297 726 dbSNP
rs183518614 732 dbSNP
rs1223018340 733 dbSNP
rs144637014 735 dbSNP
rs1030885214 743 dbSNP
rs1315358681 744 dbSNP
rs1218210787 767 dbSNP
rs1286908812 774 dbSNP
rs190529634 777 dbSNP
rs1490201237 797 dbSNP
rs1217388144 802 dbSNP
rs1364463838 803 dbSNP
rs999200373 804 dbSNP
rs967740291 807 dbSNP
rs1271721202 819 dbSNP
rs1022378863 825 dbSNP
rs1042904245 827 dbSNP
rs769659769 869 dbSNP
rs1012023968 886 dbSNP
rs1420563720 891 dbSNP
rs894876255 903 dbSNP
rs1159349390 915 dbSNP
rs186817440 918 dbSNP
rs1002971621 922 dbSNP
rs1304376706 924 dbSNP
rs907466242 928 dbSNP
rs1441311406 930 dbSNP
rs992176596 933 dbSNP
rs1375245053 934 dbSNP
rs1036536512 935 dbSNP
rs1310224231 955 dbSNP
rs940936424 957 dbSNP
rs115377267 958 dbSNP
rs1049514319 959 dbSNP
rs1204424561 966 dbSNP
rs1231574844 1008 dbSNP
rs932113743 1015 dbSNP
rs980030376 1017 dbSNP
rs1384245109 1024 dbSNP
rs1442328810 1040 dbSNP
rs777978411 1043 dbSNP
rs1385312590 1049 dbSNP
rs1409366526 1050 dbSNP
rs1168424847 1052 dbSNP
rs541064268 1054 dbSNP
rs1442702069 1056 dbSNP
rs571794744 1062 dbSNP
rs1335783079 1096 dbSNP
rs1478777595 1097 dbSNP
rs1382326731 1098 dbSNP
rs1419878068 1106 dbSNP
rs1450718032 1108 dbSNP
rs1016101092 1112 dbSNP
rs1190418156 1113 dbSNP
rs1005088196 1117 dbSNP
rs950484074 1121 dbSNP
rs767640194 1130 dbSNP
rs1030012983 1132 dbSNP
rs997159739 1139 dbSNP
rs965835429 1147 dbSNP
rs1237600976 1156 dbSNP
rs534138743 1156 dbSNP
rs923762501 1156 dbSNP
rs1184217436 1157 dbSNP
rs1474777793 1157 dbSNP
rs1421595700 1158 dbSNP
rs181126093 1163 dbSNP
rs967941477 1164 dbSNP
rs1456913066 1166 dbSNP
rs1338907962 1167 dbSNP
rs1341249148 1173 dbSNP
rs900161941 1174 dbSNP
rs1039725571 1177 dbSNP
rs77012553 1180 dbSNP
rs1219782811 1185 dbSNP
rs539175244 1188 dbSNP
rs1262979121 1189 dbSNP
rs1321829107 1195 dbSNP
rs1205223982 1202 dbSNP
rs1278934557 1204 dbSNP
rs1446018197 1207 dbSNP
rs569964953 1208 dbSNP
rs1243277326 1215 dbSNP
rs1478139727 1221 dbSNP
rs568919215 1224 dbSNP
rs1426987130 1229 dbSNP
rs753137171 1235 dbSNP
rs1042571155 1250 dbSNP
rs191208438 1251 dbSNP
rs1400268249 1252 dbSNP
rs1316392945 1274 dbSNP
rs113692398 1275 dbSNP
rs1441983885 1276 dbSNP
rs1283174316 1289 dbSNP
rs1344130498 1293 dbSNP
rs907412538 1295 dbSNP
rs1275752478 1296 dbSNP
rs761685589 1298 dbSNP
rs1036485801 1303 dbSNP
rs1202989304 1315 dbSNP
rs1005114826 1316 dbSNP
rs1488312821 1320 dbSNP
rs568305968 1320 dbSNP
rs1266707832 1333 dbSNP
rs888013298 1341 dbSNP
rs1199305370 1342 dbSNP
rs1490803017 1342 dbSNP
rs926638077 1344 dbSNP
rs1355021438 1348 dbSNP
rs1175354803 1351 dbSNP
rs980466742 1363 dbSNP
rs1382293850 1365 dbSNP
rs1420422457 1388 dbSNP
rs79676931 1401 dbSNP
rs111661985 1404 dbSNP
rs931937502 1412 dbSNP
rs1438728955 1415 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 163115.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 163115.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000358582.4 | 3UTR | AAACCCUAUGAAUGUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000358582.4 | 3UTR | AAACCCUAUGAAUGUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000358582.4 | 3UTR | AGAAACCCUAUGAAUGUAAUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000358582.4 | 3UTR | AACCCUAUGAAUGUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000358582.4 | 3UTR | AAACCCUAUGAAUGUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000358582.4 | 3UTR | AAACCCUAUGAAUGUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
203 hsa-miR-6867-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078229 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT107799 SLC1A1 solute carrier family 1 member 1 2 2
MIRT115808 CAPN15 calpain 15 2 2
MIRT137570 RCOR1 REST corepressor 1 2 2
MIRT161372 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT320477 HOXA10 homeobox A10 2 2
MIRT444449 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT461305 MRPS27 mitochondrial ribosomal protein S27 2 6
MIRT470306 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT471679 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT475546 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 2
MIRT480901 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT489368 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT489557 PLD6 phospholipase D family member 6 2 2
MIRT494969 TMEM233 transmembrane protein 233 2 2
MIRT496634 SLC46A1 solute carrier family 46 member 1 2 2
MIRT500259 ZNF788 zinc finger family member 788 2 6
MIRT500272 ZNF781 zinc finger protein 781 2 8
MIRT500328 ZNF487P zinc finger protein 487 1 3
MIRT504012 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT504830 EREG epiregulin 2 2
MIRT513588 DCTN6 dynactin subunit 6 2 2
MIRT520896 STMN1 stathmin 1 2 2
MIRT525275 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT526166 ANKRD65 ankyrin repeat domain 65 2 2
MIRT526582 CCDC43 coiled-coil domain containing 43 2 2
MIRT527812 TMEM74B transmembrane protein 74B 2 2
MIRT528141 LRRC38 leucine rich repeat containing 38 2 2
MIRT529903 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531980 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT532251 TBPL2 TATA-box binding protein like 2 2 2
MIRT534300 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT534879 QKI QKI, KH domain containing RNA binding 2 2
MIRT538305 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT539385 ADRB1 adrenoceptor beta 1 2 2
MIRT541304 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT543960 RNF20 ring finger protein 20 2 2
MIRT544380 ZNF266 zinc finger protein 266 2 2
MIRT544451 KRBOX4 KRAB box domain containing 4 2 2
MIRT545783 ZNF791 zinc finger protein 791 2 4
MIRT548156 FRAT2 FRAT2, WNT signaling pathway regulator 2 2
MIRT556660 KMT2D lysine methyltransferase 2D 2 4
MIRT557715 GABARAPL1 GABA type A receptor associated protein like 1 2 2
MIRT562701 ZNF415 zinc finger protein 415 2 2
MIRT563050 ZNF138 zinc finger protein 138 2 2
MIRT564307 CCNT1 cyclin T1 2 2
MIRT568333 BACH1 BTB domain and CNC homolog 1 2 2
MIRT570864 ZNF525 zinc finger protein 525 2 2
MIRT570874 ZFP1 ZFP1 zinc finger protein 2 2
MIRT571516 ZNF625 zinc finger protein 625 2 2
MIRT572470 MTMR10 myotubularin related protein 10 2 2
MIRT572898 RUNDC3B RUN domain containing 3B 2 2
MIRT573084 APLN apelin 2 2
MIRT575251 Timp3 tissue inhibitor of metalloproteinase 3 2 2
MIRT575275 Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT607230 LINS lines homolog 1 2 4
MIRT611803 FCRL4 Fc receptor like 4 2 2
MIRT612669 POU2F1 POU class 2 homeobox 1 2 4
MIRT612739 MYOCD myocardin 2 2
MIRT613409 CDH8 cadherin 8 2 4
MIRT614007 PAOX polyamine oxidase 2 2
MIRT615188 CLUAP1 clusterin associated protein 1 2 2
MIRT616497 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT616524 URM1 ubiquitin related modifier 1 2 2
MIRT617066 SPIB Spi-B transcription factor 2 2
MIRT617813 EMX2 empty spiracles homeobox 2 2 2
MIRT619291 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619375 KLHL12 kelch like family member 12 2 2
MIRT619499 TXLNB taxilin beta 2 2
MIRT619601 MKKS McKusick-Kaufman syndrome 2 2
MIRT619754 MYO1F myosin IF 2 2
MIRT619976 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT620743 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT620871 KCTD7 potassium channel tetramerization domain containing 7 2 2
MIRT621380 CLNK cytokine dependent hematopoietic cell linker 2 2
MIRT621511 ZNF638 zinc finger protein 638 2 2
MIRT621537 ZNF500 zinc finger protein 500 2 2
MIRT621772 TMEM87B transmembrane protein 87B 2 2
MIRT622193 SLC5A12 solute carrier family 5 member 12 2 2
MIRT622319 SEC63 SEC63 homolog, protein translocation regulator 2 2
MIRT622738 PITPNM3 PITPNM family member 3 2 2
MIRT622996 ONECUT3 one cut homeobox 3 2 2
MIRT625301 SHISA6 shisa family member 6 2 2
MIRT625637 KCNQ3 potassium voltage-gated channel subfamily Q member 3 2 2
MIRT627698 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT627751 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT628438 ANTXR2 anthrax toxin receptor 2 2 2
MIRT635440 SLC25A44 solute carrier family 25 member 44 2 2
MIRT637166 TMEM50A transmembrane protein 50A 2 2
MIRT638207 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT639288 TFAP2A transcription factor AP-2 alpha 2 4
MIRT639398 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT641230 SEMA3E semaphorin 3E 2 2
MIRT641501 STC2 stanniocalcin 2 2 2
MIRT642577 PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2 2
MIRT642735 TDRD6 tudor domain containing 6 2 2
MIRT644001 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644210 CBS cystathionine-beta-synthase 2 2
MIRT645405 FAM110A family with sequence similarity 110 member A 2 2
MIRT645685 TBC1D13 TBC1 domain family member 13 2 2
MIRT645699 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT645761 SURF6 surfeit 6 2 2
MIRT645826 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT645914 PLXNA3 plexin A3 2 2
MIRT646167 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646634 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT647547 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT648262 ZNF582 zinc finger protein 582 2 2
MIRT648385 ZNF22 zinc finger protein 22 2 2
MIRT648629 LEMD2 LEM domain containing 2 2 2
MIRT649353 SLC27A2 solute carrier family 27 member 2 2 2
MIRT649395 SH2D4A SH2 domain containing 4A 2 2
MIRT650241 CD68 CD68 molecule 2 2
MIRT650379 PTGIS prostaglandin I2 synthase 2 2
MIRT650705 KRT32 keratin 32 2 2
MIRT650854 UNC13D unc-13 homolog D 2 2
MIRT651042 ZNF644 zinc finger protein 644 2 2
MIRT651102 ZNF48 zinc finger protein 48 2 2
MIRT651130 ZNF398 zinc finger protein 398 2 2
MIRT652089 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT652200 TRIM33 tripartite motif containing 33 2 2
MIRT652422 TMEM239 transmembrane protein 239 2 2
MIRT652755 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653201 SP9 Sp9 transcription factor 2 2
MIRT653338 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653715 SLC25A32 solute carrier family 25 member 32 2 2
MIRT654456 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT654499 RABIF RAB interacting factor 2 2
MIRT654678 PSMB5 proteasome subunit beta 5 2 2
MIRT655162 PHF20L1 PHD finger protein 20 like 1 2 2
MIRT655540 PADI2 peptidyl arginine deiminase 2 2 4
MIRT655850 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT656248 MEX3A mex-3 RNA binding family member A 2 2
MIRT656581 LSAMP limbic system-associated membrane protein 2 2
MIRT657597 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT657824 GJD3 gap junction protein delta 3 2 2
MIRT658466 FAM102B family with sequence similarity 102 member B 2 2
MIRT659083 DENR density regulated re-initiation and release factor 2 2
MIRT659196 CYBB cytochrome b-245 beta chain 2 2
MIRT659558 CGGBP1 CGG triplet repeat binding protein 1 2 2
MIRT659860 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660172 BNC2 basonuclin 2 2 2
MIRT660626 ANKRD52 ankyrin repeat domain 52 2 2
MIRT660917 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT660979 ABHD2 abhydrolase domain containing 2 2 2
MIRT661564 EPHX2 epoxide hydrolase 2 2 2
MIRT662214 CCRL2 C-C motif chemokine receptor like 2 2 2
MIRT662246 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT662560 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT662591 MAGEB4 MAGE family member B4 2 2
MIRT663294 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT663437 FBXO2 F-box protein 2 2 2
MIRT663811 RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2 2
MIRT663821 NLRP12 NLR family pyrin domain containing 12 2 2
MIRT665959 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT666115 SRRM4 serine/arginine repetitive matrix 4 2 2
MIRT667448 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT669330 BSND barttin CLCNK type accessory beta subunit 2 2
MIRT669409 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669641 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT672663 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT673266 RUNDC1 RUN domain containing 1 2 2
MIRT676995 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT679290 SSBP2 single stranded DNA binding protein 2 2 2
MIRT687508 NCKAP1 NCK associated protein 1 2 2
MIRT698932 SPATA2 spermatogenesis associated 2 2 2
MIRT700852 PERP PERP, TP53 apoptosis effector 2 2
MIRT702426 KIAA1958 KIAA1958 2 2
MIRT703939 EPB41L1 erythrocyte membrane protein band 4.1 like 1 2 2
MIRT708962 SLC12A3 solute carrier family 12 member 3 2 2
MIRT709742 UBD ubiquitin D 2 2
MIRT709946 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT711121 CYYR1 cysteine and tyrosine rich 1 2 2
MIRT711217 RETSAT retinol saturase 2 2
MIRT711576 ASPA aspartoacylase 2 2
MIRT711599 LHX5 LIM homeobox 5 2 2
MIRT712232 RCC2 regulator of chromosome condensation 2 2 2
MIRT713317 TMEM44 transmembrane protein 44 2 2
MIRT713510 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT713543 GJB1 gap junction protein beta 1 2 2
MIRT713621 MED8 mediator complex subunit 8 2 2
MIRT714988 TSPAN11 tetraspanin 11 2 2
MIRT715449 PTCD1 pentatricopeptide repeat domain 1 2 2
MIRT715575 ATP5J2-PTCD1 ATP5J2-PTCD1 readthrough 2 2
MIRT715771 DDX42 DEAD-box helicase 42 2 2
MIRT715887 GNG2 G protein subunit gamma 2 2 2
MIRT716091 HARS histidyl-tRNA synthetase 2 2
MIRT717403 ZCCHC24 zinc finger CCHC-type containing 24 2 2
MIRT717965 PXMP4 peroxisomal membrane protein 4 2 2
MIRT718324 METTL7A methyltransferase like 7A 2 2
MIRT718628 DIP2A disco interacting protein 2 homolog A 2 2
MIRT719213 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT719234 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719817 LRRC4 leucine rich repeat containing 4 2 2
MIRT719978 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720480 TMEM178B transmembrane protein 178B 2 2
MIRT720713 RAPGEF6 Rap guanine nucleotide exchange factor 6 2 2
MIRT721006 ZNF619 zinc finger protein 619 2 2
MIRT721741 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT723547 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT723596 FKRP fukutin related protein 2 2
MIRT723746 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT724784 C1D C1D nuclear receptor corepressor 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6867-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)

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