miRTarBase - #MIRT500751


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pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMPPE   
Synonyms -
Description transmembrane protein with metallophosphoesterase domain
Transcript NM_001039770   
Other Transcripts NM_001136238   
Expression
Putative miRNA Targets on TMPPE
3'UTR of TMPPE
(miRNA target sites are highlighted)		 
>TMPPE|NM_001039770|3'UTR
   1 ACTGGCCCTGCCCTGTGCACCTCTGCCCTGCCCTTGTCCTCGACCCTCCATCCTGCTTCAGAGTGGTTTGCCTGCTTTTC
  81 CCCTCCAGCCTTGCCCACTCATCCTTGCCTACACACCCTTGGTCACAAGCCTGACTCAAACAGTGACTTATGGTGGGCCT
 161 GCCTGGCATGTTCAGGCTGGTTTAACTATTTCCTTGGCCAGTTGCTTTTTTTGATGCACTTGTGAGATCACTAAGGTCAC
 241 ATATATTAGCACTCCCCTCTATTTTCCAGATGATGTGGAATGGGGACCTTCTCCTGCAGAGCTCCCAGGGATGAACCTCC
 321 CCTCGGGGTTGCTAGAAAGGCATACCTCTAGAAGGTGGGGCGGGGAGGAGCAGGAGCATTTTTCTCCTGGTGTTTTAAAA
 401 TTGTCTTTAGGACTTAAGTGGTTTCCAGAATCATTGATCCAGAGCCTTTCTGGGGAAGGGGTAGTGTTGCCAGGTAATTT
 481 GGGAGAACAGGCAAGATGGAAGGGCCCTCTGGCTGCTAGAGAAGAATATTTTCTTTTCCTCTGATTCTATCAGGATCACC
 561 TCTATTGAGGGCATCAGCAAAATCTACTGGAATGCAAAGCTCCTCCTGTTCCAGGCCTTGAGGGATGCTATTTAACTGTC
 641 TGTGCTCCTGGGCCTTTGGGGGCAAGGTCAGGGGAGAAGAACGGTGGGCGCCATGGTCGGTGATGGTGAGAACATGGCTG
 721 CTTAGGAATTCAGAGGGCTTTGCCTCCCTTGTCTCATTTTATACAACCCTTCGGGGAGCTCACTGGGGACAGGCTGCTTT
 801 TCCCTATTTGGAGATAAGGAAACCAAGGCAAAGAGAGATAGGGCACAGGCAGTATGACAAGATATGTAGGAGATTTGGGG
 881 CTAGAAACCAGGTCTTGTACCTCCCAGTAAAAGCGGTGCTTTTGCCCTTTTGCCAGAAGCAATAGATCCTTTGATCCTGA
 961 GATGGAGATAAGCACCCGTGTTAGAAAAGGCCTCACTGAGAAGACAGGGCTGGGCTGGTTTCCTGCTGGGTGATTTAGGC
1041 TTGTGATGGAAAGTCTTCCTCCAATGGGGAGTGAAGACACTCGCTCTGACTGGAGAGGCTAACCCTGCTGCTCACTCATA
1121 GGGCAGCGTTGGGTGGGTGACTTTCCCTCACTCAGCCTTGGTTTCCATCAACCCTAAAATGGGGATAATTATCGTATCTA
1201 CCTCAAGATTGTTTTGTCAGGAGGGATCCATCAAGCCTTGTGCATGAGTTCCACATGGCACAGCGTGCACAGTAAACACT
1281 CAATGTTAATTTTTCAACGTTCCAGTGGAGCTTGCTAAGGAACTCTGTTGGGCACAGGTGCCCAGAGGATTCATGGAGCA
1361 GCCAGTCCTGGGGAATGTGAGTGGGTAGCGAGCTGCCTGCTGCTGGGGCAGGTGATGTGTCAAAGCAGCAACTGCTAGGG
1441 GTTTGCCTTCCTTCCCTCATGTGCATTCTGGCAGGCAAAGGGGGTTTCTTCCTTTCCTCCTTGTCCTCCTGGTGTATAGT
1521 GGGGTTCTGGGGGATCTGGAGACCACCCTTTTTGTTCCCAGGCAGCCACGGTATTGACAGTGGGCCATACCATGCAGTTT
1601 AAAATGTATCTTTGAGTTGAAATTTTGGTGGTTTCCTTATTCTTTTTTCTCTCTTCACTGTCCTTCCAAACTCACTTTTC
1681 TTGTGTCCCGACCGCATTTTGTGAATCATCCTTACTCCCTTTAAGTTCTCGCTTTGGATTTCACCAGGTGGGCTAGATGG
1761 TGCCATTTCACTTCCACTGTTTGATGCGGCTGGTAATGTTTGACTCACCTGTTACGTGTTATTTCACTGGTTTCTTGATT
1841 TTACATCTTTCTCATCAGTGACCTGGGCTTGATGAAATTAGCTTTCATTAAGTCCTATTTTTTTTTTAATTTTGCATCCT
1921 TACCTCTTTTCTTTCTCTTGAATGCCATCATTGTGTGGTCTTATGTACCCTTCATCCACTCTGAAGTCCTTGCTTGACTG
2001 ATTGCTTTCTATTAGCAGAAAGAAAACAGGTCCATCCTATGTATCTGAGAAACAACATCAACACCCTCTCGTATGTGGTT
2081 TGTATTCCCTGACGCGGCGGACATTTTTGCAGCAGAAATTTCTCCATCACTGTCCAGATTCTGGCCCTGGTGGGCAGGTC
2161 TCCATGACACCTTTAGTCCCTTTGTTCAACATTCTTAAACCATGGACCTTTTTGTTTGTTTGTGGCCGGGGGAGGTGGTG
2241 AGAAACGTTACTTGAAGCTTGATCATTCTTTCAATTTCATTTGTTTCTTTATTTTTAATCTGTTAGATGCAAATTGAAAT
2321 GCAATGCTTTTTGAAAATCAGCAATAGTGTCTGTAGTATATGATGCTGTCACAAAATCTCAATAAATTGATCCTGCTGCC
2401 ATTCCTTCCAAATACCCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agaUUGUG-----GUGUCACACCAAAc 5'
             |||||     |::| |||||||| 
Target 5' atcAACACCCTCTCGTA-TGTGGTTTg 3'
 2057 - 2082 158.00 -19.10
2 
miRNA  3' agauuGUGGUGUCACACCAAAc 5'
               ::|: ||| ||||||| 
Target 5' catccTGCTTCAGAGTGGTTTg 3'
 49 - 70 157.00 -15.70
3 
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            ||: ||:  |  ||||||| 
Target 5' ttTAGGACTTAA--GTGGTTTc 3'
 406 - 425 148.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26999185 10 COSMIC
COSN30463733 13 COSMIC
COSN30464543 28 COSMIC
COSN30477435 33 COSMIC
COSN14060285 41 COSMIC
COSN30463712 41 COSMIC
COSN31514301 79 COSMIC
COSN30165531 100 COSMIC
COSN30530426 104 COSMIC
COSN25757294 689 COSMIC
COSN18723535 875 COSMIC
COSN29544327 977 COSMIC
COSN27573736 1499 COSMIC
COSN25316336 1696 COSMIC
COSN7606246 2098 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754255022 2 dbSNP
rs1220323010 6 dbSNP
rs927222461 7 dbSNP
rs1356779854 10 dbSNP
rs778222963 13 dbSNP
rs1276391363 19 dbSNP
rs1354785484 20 dbSNP
rs756708185 25 dbSNP
rs753218591 29 dbSNP
rs1293273941 35 dbSNP
rs777541686 36 dbSNP
rs767096951 37 dbSNP
rs758950218 39 dbSNP
rs751284222 41 dbSNP
rs114144251 42 dbSNP
rs762528468 44 dbSNP
rs773006491 46 dbSNP
rs377398538 48 dbSNP
rs761777784 50 dbSNP
rs974648259 55 dbSNP
rs754989419 61 dbSNP
rs1260546114 62 dbSNP
rs1442676994 72 dbSNP
rs913244018 78 dbSNP
rs1366512191 80 dbSNP
rs943204669 81 dbSNP
rs1159813295 89 dbSNP
rs1285208044 90 dbSNP
rs911699153 93 dbSNP
rs1458871351 96 dbSNP
rs988783630 107 dbSNP
rs986899783 111 dbSNP
rs1336461007 112 dbSNP
rs143210705 117 dbSNP
rs1339069120 130 dbSNP
rs1331382513 131 dbSNP
rs1289498698 137 dbSNP
rs1020101961 138 dbSNP
rs72856190 143 dbSNP
rs1345217240 150 dbSNP
rs1025718613 151 dbSNP
rs972766289 153 dbSNP
rs962741610 159 dbSNP
rs1370582703 166 dbSNP
rs1167603449 168 dbSNP
rs1253729767 180 dbSNP
rs1017608436 186 dbSNP
rs1485206910 187 dbSNP
rs1001761604 192 dbSNP
rs906040502 193 dbSNP
rs1253828446 198 dbSNP
rs1427462985 213 dbSNP
rs1156957923 217 dbSNP
rs757811652 219 dbSNP
rs1014357778 220 dbSNP
rs891576155 235 dbSNP
rs57682151 247 dbSNP
rs115764170 254 dbSNP
rs1414494588 266 dbSNP
rs578140443 270 dbSNP
rs1309049856 275 dbSNP
rs1014554781 277 dbSNP
rs1004929675 293 dbSNP
rs1039375412 294 dbSNP
rs1235680826 296 dbSNP
rs1183846530 302 dbSNP
rs552338160 304 dbSNP
rs1234836929 320 dbSNP
rs895589840 323 dbSNP
rs943274804 324 dbSNP
rs911791613 325 dbSNP
rs557819483 327 dbSNP
rs1251226318 328 dbSNP
rs1203086270 329 dbSNP
rs1042879519 331 dbSNP
rs987329316 337 dbSNP
rs929114211 343 dbSNP
rs1053149530 349 dbSNP
rs944026671 350 dbSNP
rs918716380 361 dbSNP
rs972806368 362 dbSNP
rs1372786922 368 dbSNP
rs1354615853 387 dbSNP
rs1281803337 390 dbSNP
rs912683705 392 dbSNP
rs1368983596 395 dbSNP
rs1387959514 397 dbSNP
rs867460201 403 dbSNP
rs190393798 404 dbSNP
rs777861521 410 dbSNP
rs980780967 413 dbSNP
rs970360934 415 dbSNP
rs1299444997 420 dbSNP
rs920099651 421 dbSNP
rs1203618656 427 dbSNP
rs1265908522 430 dbSNP
rs974181925 432 dbSNP
rs1211642842 435 dbSNP
rs961621315 441 dbSNP
rs1453927210 452 dbSNP
rs1189451243 454 dbSNP
rs1015779837 461 dbSNP
rs1392301800 465 dbSNP
rs1004580254 471 dbSNP
rs1351264237 488 dbSNP
rs959965324 491 dbSNP
rs566139698 499 dbSNP
rs1323746282 505 dbSNP
rs547830265 507 dbSNP
rs1292350273 508 dbSNP
rs1411313192 511 dbSNP
rs1161067599 515 dbSNP
rs1435233234 521 dbSNP
rs1322108653 524 dbSNP
rs1472906018 529 dbSNP
rs60798803 530 dbSNP
rs1031390529 533 dbSNP
rs752898993 544 dbSNP
rs1180195361 549 dbSNP
rs904203930 558 dbSNP
rs1038718692 559 dbSNP
rs1007623049 564 dbSNP
rs1247524526 565 dbSNP
rs1250085119 590 dbSNP
rs551287893 593 dbSNP
rs769168373 597 dbSNP
rs1414955946 600 dbSNP
rs1425992661 601 dbSNP
rs747877211 603 dbSNP
rs1051677609 607 dbSNP
rs929128988 611 dbSNP
rs1417831845 622 dbSNP
rs1457264326 628 dbSNP
rs145092087 633 dbSNP
rs1037537372 638 dbSNP
rs1429605533 640 dbSNP
rs1209722919 642 dbSNP
rs1329135857 644 dbSNP
rs941431666 645 dbSNP
rs1292575637 647 dbSNP
rs1329802963 658 dbSNP
rs912558641 659 dbSNP
rs1315297082 666 dbSNP
rs909939877 669 dbSNP
rs1238307474 671 dbSNP
rs544174256 671 dbSNP
rs780990244 672 dbSNP
rs970023464 674 dbSNP
rs932750184 675 dbSNP
rs1257380926 678 dbSNP
rs1473206239 680 dbSNP
rs532024317 682 dbSNP
rs1435361376 683 dbSNP
rs781691359 688 dbSNP
rs917502206 689 dbSNP
rs564560833 690 dbSNP
rs1176295497 693 dbSNP
rs1360589747 698 dbSNP
rs993006570 699 dbSNP
rs974232900 707 dbSNP
rs117541625 710 dbSNP
rs1031776486 715 dbSNP
rs1156786366 730 dbSNP
rs908827828 741 dbSNP
rs755453646 765 dbSNP
rs572067041 766 dbSNP
rs1000751478 772 dbSNP
rs968524349 773 dbSNP
rs1314194114 777 dbSNP
rs1209087047 779 dbSNP
rs1017762047 783 dbSNP
rs1007262945 788 dbSNP
rs370137420 790 dbSNP
rs1051691955 791 dbSNP
rs1231713587 793 dbSNP
rs1469164761 794 dbSNP
rs536553299 817 dbSNP
rs1191292177 820 dbSNP
rs1426786224 827 dbSNP
rs1432487165 831 dbSNP
rs969819558 835 dbSNP
rs1021371959 846 dbSNP
rs1370928343 860 dbSNP
rs186330143 864 dbSNP
rs574045039 865 dbSNP
rs1477188763 868 dbSNP
rs555734051 870 dbSNP
rs1353878718 877 dbSNP
rs1441512343 882 dbSNP
rs747321042 883 dbSNP
rs1011451925 900 dbSNP
rs531165765 904 dbSNP
rs1031466801 906 dbSNP
rs897682192 914 dbSNP
rs570707753 915 dbSNP
rs1271444357 916 dbSNP
rs753605646 942 dbSNP
rs941846514 946 dbSNP
rs1050207318 954 dbSNP
rs1206083686 956 dbSNP
rs1313267661 973 dbSNP
rs1278778928 977 dbSNP
rs1218119503 978 dbSNP
rs149919617 988 dbSNP
rs898613963 990 dbSNP
rs1458664508 993 dbSNP
rs1299276894 1000 dbSNP
rs1044872038 1006 dbSNP
rs780710690 1013 dbSNP
rs940231569 1017 dbSNP
rs908706339 1019 dbSNP
rs948730338 1033 dbSNP
rs1396781889 1036 dbSNP
rs992311436 1042 dbSNP
rs1325447319 1048 dbSNP
rs533956953 1064 dbSNP
rs926877102 1069 dbSNP
rs979794237 1070 dbSNP
rs1339239749 1072 dbSNP
rs1229384970 1073 dbSNP
rs1275677912 1074 dbSNP
rs1412935228 1078 dbSNP
rs969706690 1082 dbSNP
rs1465977601 1083 dbSNP
rs993057390 1083 dbSNP
rs1412829812 1084 dbSNP
rs956313632 1099 dbSNP
rs1021426130 1103 dbSNP
rs566052961 1110 dbSNP
rs1164894653 1118 dbSNP
rs1415647304 1119 dbSNP
rs978985328 1122 dbSNP
rs955783278 1123 dbSNP
rs1384152754 1125 dbSNP
rs1389571363 1125 dbSNP
rs969287320 1127 dbSNP
rs1017355096 1128 dbSNP
rs1295595755 1129 dbSNP
rs1007283390 1134 dbSNP
rs1333373300 1140 dbSNP
rs1008037203 1147 dbSNP
rs1246616036 1150 dbSNP
rs891057805 1153 dbSNP
rs1268222989 1157 dbSNP
rs758897598 1157 dbSNP
rs1203000554 1178 dbSNP
rs1483900283 1182 dbSNP
rs139154601 1187 dbSNP
rs150633243 1193 dbSNP
rs1038293517 1198 dbSNP
rs1255272500 1199 dbSNP
rs375997439 1204 dbSNP
rs1474843437 1213 dbSNP
rs1412783126 1216 dbSNP
rs940116619 1216 dbSNP
rs1455476776 1217 dbSNP
rs1157018647 1224 dbSNP
rs897775626 1226 dbSNP
rs765404680 1232 dbSNP
rs1415358909 1234 dbSNP
rs1315181272 1238 dbSNP
rs1354045710 1246 dbSNP
rs36075372 1253 dbSNP
rs887176945 1255 dbSNP
rs1289598827 1264 dbSNP
rs142859087 1265 dbSNP
rs1340978131 1269 dbSNP
rs1006093696 1270 dbSNP
rs1397547207 1274 dbSNP
rs1379890955 1282 dbSNP
rs939522485 1283 dbSNP
rs1277943790 1286 dbSNP
rs757252252 1297 dbSNP
rs1182810945 1298 dbSNP
rs904989568 1299 dbSNP
rs926903470 1304 dbSNP
rs1179782930 1313 dbSNP
rs1372443276 1327 dbSNP
rs550185272 1329 dbSNP
rs1478485920 1340 dbSNP
rs1175822901 1344 dbSNP
rs1374020199 1352 dbSNP
rs981020317 1357 dbSNP
rs1169267483 1365 dbSNP
rs946915151 1368 dbSNP
rs1389135392 1375 dbSNP
rs531941264 1389 dbSNP
rs1429404662 1390 dbSNP
rs1331270153 1395 dbSNP
rs564771659 1399 dbSNP
rs1388540621 1402 dbSNP
rs1167437928 1410 dbSNP
rs1424694638 1414 dbSNP
rs1413725007 1426 dbSNP
rs1252956696 1429 dbSNP
rs1180570154 1431 dbSNP
rs989787546 1433 dbSNP
rs181498222 1436 dbSNP
rs1031399853 1440 dbSNP
rs1469015261 1446 dbSNP
rs1044499558 1451 dbSNP
rs10865849 1453 dbSNP
rs559819297 1456 dbSNP
rs1192217810 1458 dbSNP
rs116853659 1459 dbSNP
rs1253393345 1461 dbSNP
rs955225518 1465 dbSNP
rs1480020544 1469 dbSNP
rs1298165874 1471 dbSNP
rs1390823330 1473 dbSNP
rs1028235241 1475 dbSNP
rs574183152 1477 dbSNP
rs1369822805 1497 dbSNP
rs1228777836 1502 dbSNP
rs924925789 1512 dbSNP
rs1482557184 1516 dbSNP
rs962568258 1521 dbSNP
rs1016909780 1534 dbSNP
rs1004152979 1537 dbSNP
rs1322036698 1539 dbSNP
rs979382760 1544 dbSNP
rs1335524123 1549 dbSNP
rs562176735 1554 dbSNP
rs1251330495 1563 dbSNP
rs544171229 1566 dbSNP
rs188214950 1569 dbSNP
rs11711396 1570 dbSNP
rs1264285678 1570 dbSNP
rs1419274147 1571 dbSNP
rs1462517613 1572 dbSNP
rs1162171983 1577 dbSNP
rs1393200192 1579 dbSNP
rs1435342578 1580 dbSNP
rs1030074186 1583 dbSNP
rs1359563516 1585 dbSNP
rs375165483 1586 dbSNP
rs1308778704 1589 dbSNP
rs946967455 1592 dbSNP
rs1235142635 1605 dbSNP
rs971759312 1606 dbSNP
rs962012894 1610 dbSNP
rs915471920 1619 dbSNP
rs201587522 1627 dbSNP
rs1006521378 1632 dbSNP
rs1295450196 1649 dbSNP
rs1485086707 1650 dbSNP
rs554794864 1651 dbSNP
rs1258785630 1653 dbSNP
rs757642612 1656 dbSNP
rs1054145489 1671 dbSNP
rs1186494658 1675 dbSNP
rs1416515987 1687 dbSNP
rs528937738 1689 dbSNP
rs568546200 1690 dbSNP
rs1013358820 1693 dbSNP
rs895937030 1694 dbSNP
rs1473883758 1696 dbSNP
rs1413326023 1700 dbSNP
rs1313266825 1711 dbSNP
rs1357225622 1715 dbSNP
rs986564373 1718 dbSNP
rs1292669471 1719 dbSNP
rs1354870687 1724 dbSNP
rs569277545 1730 dbSNP
rs1309365101 1731 dbSNP
rs183853728 1737 dbSNP
rs538204327 1743 dbSNP
rs921103323 1744 dbSNP
rs975186628 1747 dbSNP
rs1257504116 1748 dbSNP
rs962627152 1757 dbSNP
rs1488585983 1765 dbSNP
rs72856187 1775 dbSNP
rs768404814 1776 dbSNP
rs1211576175 1782 dbSNP
rs1331230442 1784 dbSNP
rs1173931899 1785 dbSNP
rs1004655522 1787 dbSNP
rs1432700164 1788 dbSNP
rs1211804337 1796 dbSNP
rs1288838811 1798 dbSNP
rs951411973 1806 dbSNP
rs910788690 1807 dbSNP
rs1003640802 1808 dbSNP
rs1348660525 1813 dbSNP
rs1239659585 1815 dbSNP
rs905251159 1815 dbSNP
rs1045278438 1816 dbSNP
rs1390256564 1823 dbSNP
rs552789891 1830 dbSNP
rs368301816 1857 dbSNP
rs1292203618 1858 dbSNP
rs140014506 1859 dbSNP
rs986327652 1878 dbSNP
rs147454856 1885 dbSNP
rs1390024794 1886 dbSNP
rs923055747 1891 dbSNP
rs1456268553 1894 dbSNP
rs971769160 1907 dbSNP
rs140320259 1908 dbSNP
rs894089354 1908 dbSNP
rs1361603846 1909 dbSNP
rs548355737 1911 dbSNP
rs1433470351 1914 dbSNP
rs934359178 1918 dbSNP
rs538819626 1919 dbSNP
rs181831538 1923 dbSNP
rs1268720243 1929 dbSNP
rs1207985587 1937 dbSNP
rs1373476941 1947 dbSNP
rs114462916 1949 dbSNP
rs920995308 1963 dbSNP
rs1216799531 1968 dbSNP
rs975246986 1969 dbSNP
rs1306399395 1970 dbSNP
rs1213782875 1972 dbSNP
rs1023498350 1978 dbSNP
rs1192718959 1983 dbSNP
rs1257882466 1988 dbSNP
rs543876565 1991 dbSNP
rs576726047 1992 dbSNP
rs564724314 2008 dbSNP
rs777099902 2010 dbSNP
rs941190055 2011 dbSNP
rs1418730378 2029 dbSNP
rs960486497 2030 dbSNP
rs540563533 2033 dbSNP
rs544353456 2037 dbSNP
rs373575013 2039 dbSNP
rs1165791637 2041 dbSNP
rs560095622 2054 dbSNP
rs1438955141 2055 dbSNP
rs752142709 2058 dbSNP
rs903204642 2070 dbSNP
rs1043476357 2071 dbSNP
rs759335347 2073 dbSNP
rs1268873291 2075 dbSNP
rs1404967964 2077 dbSNP
rs1011565871 2086 dbSNP
rs189476239 2087 dbSNP
rs1050665254 2091 dbSNP
rs771367828 2093 dbSNP
rs982499450 2095 dbSNP
rs1208869315 2098 dbSNP
rs1376733638 2099 dbSNP
rs923400858 2101 dbSNP
rs536424942 2103 dbSNP
rs1241409984 2109 dbSNP
rs143050102 2111 dbSNP
rs1420074617 2112 dbSNP
rs940458818 2120 dbSNP
rs185079305 2128 dbSNP
rs1162875571 2133 dbSNP
rs1385959883 2134 dbSNP
rs1402733412 2142 dbSNP
rs575286004 2147 dbSNP
rs762998855 2150 dbSNP
rs1360389588 2153 dbSNP
rs1415908151 2160 dbSNP
rs984897680 2164 dbSNP
rs375369656 2171 dbSNP
rs1279706689 2172 dbSNP
rs1330286865 2173 dbSNP
rs7612234 2182 dbSNP
rs1285017286 2185 dbSNP
rs916499422 2187 dbSNP
rs1485899252 2189 dbSNP
rs1031547953 2190 dbSNP
rs1255387123 2194 dbSNP
rs1474232571 2205 dbSNP
rs1258171189 2227 dbSNP
rs1201111094 2234 dbSNP
rs1471290649 2242 dbSNP
rs1157094761 2245 dbSNP
rs1344326588 2246 dbSNP
rs552279483 2247 dbSNP
rs1315288981 2249 dbSNP
rs890672481 2264 dbSNP
rs960540057 2266 dbSNP
rs1394907506 2268 dbSNP
rs534254561 2272 dbSNP
rs1050800079 2273 dbSNP
rs139306479 2274 dbSNP
rs1308162901 2279 dbSNP
rs1348308783 2280 dbSNP
rs1343113299 2283 dbSNP
rs1236235799 2287 dbSNP
rs748164891 2299 dbSNP
rs999350674 2323 dbSNP
rs376121468 2324 dbSNP
rs548394890 2325 dbSNP
rs967896954 2328 dbSNP
rs78125532 2339 dbSNP
rs75638506 2341 dbSNP
rs982996215 2344 dbSNP
rs550698466 2345 dbSNP
rs555420624 2359 dbSNP
rs1465961977 2368 dbSNP
rs1310506871 2376 dbSNP
rs1398002819 2380 dbSNP
rs144399614 2381 dbSNP
rs997744004 2382 dbSNP
rs539827965 2395 dbSNP
rs902077593 2396 dbSNP
rs1442774615 2410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 643853.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 643853.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000416695.2 | 3UTR | UCAGGCUGGUUUAACUAUUUCCUUGGCCAGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000416695.2 | 3UTR | UUUAACUAUUUCCUUGGCCAGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000416695.2 | 3UTR | UUUAACUAUUUCCUUGGCCAGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000416695.2 | 3UTR | UUUAACUAUUUCCUUGGCCAGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000416695.2 | 3UTR | UUUAACUAUUUCCUUGGCCAGUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.504 7.1e-3 0.468 1.2e-2 23 Click to see details
GSE28260 Renal cortex and medulla -0.568 2.1e-2 -0.749 1.6e-3 13 Click to see details
GSE38226 Liver fibrosis 0.167 2.3e-1 -0.001 5.0e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells 0.045 4.2e-1 -0.175 2.1e-1 24 Click to see details
GSE28544 Breast cancer 0.007 4.9e-1 0.069 3.7e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.256 0.05 0.222 0.08 42 Click to see details
BLCA -0.8 0.1 -0.800 0.1 4 Click to see details
PAAD 0.734 0.13 0.400 0.3 4 Click to see details
CHOL 0.412 0.21 0.257 0.31 6 Click to see details
KIRP -0.176 0.22 -0.130 0.29 21 Click to see details
PRAD -0.09 0.28 -0.045 0.38 46 Click to see details
KIRC 0.067 0.33 0.098 0.27 43 Click to see details
LIHC -0.08 0.34 -0.021 0.46 30 Click to see details
KICH -0.105 0.35 -0.107 0.35 15 Click to see details
ESCA -0.132 0.36 0.030 0.47 10 Click to see details
LUAD -0.236 0.38 -0.400 0.3 4 Click to see details
STAD 0.068 0.38 -0.140 0.27 21 Click to see details
THCA -0.044 0.39 0.052 0.37 45 Click to see details
HNSC 0.037 0.44 0.189 0.23 18 Click to see details
UCEC -0.038 0.44 0.056 0.42 16 Click to see details
LUSC 0.026 0.45 0.055 0.39 30 Click to see details
LUSC 0.026 0.45 0.055 0.39 30 Click to see details
LUSC 0.026 0.45 0.055 0.39 30 Click to see details
LUSC 0.026 0.45 0.055 0.39 30 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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