ID	Duplex structure	Position	Score	MFE
1	miRNA 3' ucGUUG-UGGCGUCGCUGUUcg 5' ::|| ::| | :||||| Target 5' atTGACTTTTGAATTGACAAtc 3'	62 - 83	111.00	-6.60
2	miRNA 3' ucgUUGUGGCGUCGCUGUUcg 5' |:| : |:| :||||: Target 5' atgAGC-TGGTACTGACAGtt 3'	125 - 144	97.00	-10.26
3	miRNA 3' ucgUUGU--GGCGUCGCUGUUCg 5' || | |: || :||:| | Target 5' tgaAAGAGTCTTCAATGATATGc 3'	84 - 106	88.00	-6.60

Mutant ID	Mutant Position	Mutant Source
COSN18738857	31	COSMIC
COSN30167932	51	COSMIC
COSN30101894	52	COSMIC
COSN24399755	91	COSMIC
COSN30116465	98	COSMIC
COSN30530877	103	COSMIC
COSN17733744	507	COSMIC
COSN22223239	772	COSMIC
COSN25078795	1089	COSMIC
COSN1678593	1251	COSMIC
COSN1678592	1252	COSMIC
COSN24935298	2236	COSMIC
COSN30445613	2407	COSMIC
COSN23778323	2445	COSMIC
COSN7047623	2445	COSMIC
COSN17532964	2580	COSMIC
COSN22567428	2767	COSMIC
COSN29354666	2914	COSMIC
COSN25166750	2980	COSMIC
COSN15845363	3052	COSMIC
COSN21928055	3250	COSMIC
COSN27369525	3258	COSMIC
COSN29715748	3748	COSMIC
COSN25302585	3822	COSMIC
COSN29744719	4436	COSMIC
COSN18782513	4442	COSMIC
COSN6641975	4442	COSMIC
COSN17953183	4444	COSMIC
COSN25612481	5199	COSMIC
rs12900430	3528	GWAS

Mutant ID	Mutant Position	Mutant Source
rs1338235424	3	dbSNP
rs780701484	6	dbSNP
rs754458986	7	dbSNP
rs1332225423	13	dbSNP
rs985106083	18	dbSNP
rs780488291	20	dbSNP
rs776463479	23	dbSNP
rs758774250	32	dbSNP
rs750833139	35	dbSNP
rs1327486488	38	dbSNP
rs1302189596	39	dbSNP
rs1390875650	40	dbSNP
rs957668593	45	dbSNP
rs1397383419	48	dbSNP
rs765417681	51	dbSNP
rs1032056123	52	dbSNP
rs999723245	54	dbSNP
rs1369873587	63	dbSNP
rs138927227	74	dbSNP
rs571304544	85	dbSNP
rs74983758	88	dbSNP
rs1318894491	90	dbSNP
rs1011845537	98	dbSNP
rs1294689286	103	dbSNP
rs893422118	104	dbSNP
rs1034582435	106	dbSNP
rs539516977	107	dbSNP
rs571467974	108	dbSNP
rs1247914158	116	dbSNP
rs1474117428	117	dbSNP
rs1014404292	120	dbSNP
rs896072120	133	dbSNP
rs1466864167	145	dbSNP
rs1173262149	153	dbSNP
rs760528018	155	dbSNP
rs569517943	164	dbSNP
rs930015204	165	dbSNP
rs1001542023	170	dbSNP
rs897169872	175	dbSNP
rs1461466275	182	dbSNP
rs1428654864	185	dbSNP
rs1277652573	188	dbSNP
rs1341358206	212	dbSNP
rs1038746224	213	dbSNP
rs1291187914	223	dbSNP
rs888408484	227	dbSNP
rs941350499	229	dbSNP
rs551144626	230	dbSNP
rs1453631286	241	dbSNP
rs930085668	246	dbSNP
rs529569976	258	dbSNP
rs1215176495	259	dbSNP
rs11312848	268	dbSNP
rs1478588626	268	dbSNP
rs398027248	268	dbSNP
rs922394673	268	dbSNP
rs1472648574	269	dbSNP
rs977870809	269	dbSNP
rs1164216298	270	dbSNP
rs1211604581	280	dbSNP
rs966833823	287	dbSNP
rs1022031889	297	dbSNP
rs1489491562	297	dbSNP
rs8040136	299	dbSNP
rs760887230	300	dbSNP
rs146447205	303	dbSNP
rs1311761615	326	dbSNP
rs1232534438	332	dbSNP
rs911147203	336	dbSNP
rs528522638	338	dbSNP
rs1245171389	343	dbSNP
rs1285733691	344	dbSNP
rs564118886	345	dbSNP
rs1348446969	353	dbSNP
rs1239403010	363	dbSNP
rs1034636957	365	dbSNP
rs545942529	371	dbSNP
rs1208134099	376	dbSNP
rs1001754753	377	dbSNP
rs907374446	380	dbSNP
rs575326894	388	dbSNP
rs181667895	391	dbSNP
rs567836853	392	dbSNP
rs966887878	393	dbSNP
rs1024700593	394	dbSNP
rs993415599	403	dbSNP
rs544349551	404	dbSNP
rs142348334	408	dbSNP
rs1034602606	409	dbSNP
rs1001825158	414	dbSNP
rs138117429	415	dbSNP
rs549656463	417	dbSNP
rs994162996	418	dbSNP
rs897245433	419	dbSNP
rs572901621	423	dbSNP
rs1005546650	425	dbSNP
rs557783399	426	dbSNP
rs943872883	429	dbSNP
rs889657592	432	dbSNP
rs1231355604	433	dbSNP
rs1254975161	434	dbSNP
rs1260968094	434	dbSNP
rs1049639023	435	dbSNP
rs188643878	436	dbSNP
rs1488691936	437	dbSNP
rs568932072	440	dbSNP
rs925186242	441	dbSNP
rs1442088984	442	dbSNP
rs1196837628	443	dbSNP
rs978177217	447	dbSNP
rs945029828	448	dbSNP
rs549710974	452	dbSNP
rs1398407882	453	dbSNP
rs991881857	454	dbSNP
rs767447888	459	dbSNP
rs183865904	461	dbSNP
rs1385068512	462	dbSNP
rs1299965498	466	dbSNP
rs761758180	472	dbSNP
rs989223325	473	dbSNP
rs980253110	476	dbSNP
rs952964249	479	dbSNP
rs150435817	481	dbSNP
rs376383276	482	dbSNP
rs1190028181	489	dbSNP
rs1266717307	492	dbSNP
rs1433800556	493	dbSNP
rs527843055	493	dbSNP
rs774150650	494	dbSNP
rs1402258784	498	dbSNP
rs961363787	499	dbSNP
rs28373855	509	dbSNP
rs766379451	510	dbSNP
rs567357958	512	dbSNP
rs994766066	519	dbSNP
rs1339439350	521	dbSNP
rs1218923361	524	dbSNP
rs889856538	525	dbSNP
rs777366764	532	dbSNP
rs1219860374	533	dbSNP
rs560781424	536	dbSNP
rs1372420218	540	dbSNP
rs1211713377	550	dbSNP
rs1261201771	553	dbSNP
rs1017007524	558	dbSNP
rs1194707233	559	dbSNP
rs1194821584	568	dbSNP
rs1171380522	569	dbSNP
rs1005557972	580	dbSNP
rs903790964	581	dbSNP
rs1459439362	582	dbSNP
rs528758305	588	dbSNP
rs1049693273	589	dbSNP
rs1265492145	591	dbSNP
rs1299604436	594	dbSNP
rs945037541	600	dbSNP
rs1185929611	602	dbSNP
rs78789557	606	dbSNP
rs1322840469	609	dbSNP
rs1248867126	610	dbSNP
rs1056525380	614	dbSNP
rs1487982130	615	dbSNP
rs937772319	620	dbSNP
rs1337928621	621	dbSNP
rs552114503	629	dbSNP
rs926341367	642	dbSNP
rs980284298	643	dbSNP
rs915047488	647	dbSNP
rs1156818141	659	dbSNP
rs1290862735	662	dbSNP
rs12912843	664	dbSNP
rs12912841	665	dbSNP
rs71207377	665	dbSNP
rs796084865	666	dbSNP
rs1446917363	673	dbSNP
rs981800064	673	dbSNP
rs1380401582	675	dbSNP
rs1454946142	677	dbSNP
rs970398930	686	dbSNP
rs1335848356	690	dbSNP
rs917527670	692	dbSNP
rs1240878061	694	dbSNP
rs972999784	696	dbSNP
rs12911654	698	dbSNP
rs529118061	714	dbSNP
rs1256334641	729	dbSNP
rs961923198	731	dbSNP
rs561709545	732	dbSNP
rs72740493	739	dbSNP
rs559460615	740	dbSNP
rs954149888	745	dbSNP
rs1028333227	750	dbSNP
rs1413528710	752	dbSNP
rs1176286142	755	dbSNP
rs1000660342	758	dbSNP
rs1467075517	760	dbSNP
rs1329735848	768	dbSNP
rs750942022	778	dbSNP
rs903644526	782	dbSNP
rs1042610422	783	dbSNP
rs1281329988	799	dbSNP
rs1021300138	800	dbSNP
rs542372160	801	dbSNP
rs1415584866	803	dbSNP
rs1009520307	810	dbSNP
rs1162807563	813	dbSNP
rs573165015	816	dbSNP
rs531492154	817	dbSNP
rs745552526	818	dbSNP
rs1257253705	821	dbSNP
rs1009448577	826	dbSNP
rs865882057	847	dbSNP
rs557795883	851	dbSNP
rs1244943247	856	dbSNP
rs545768968	856	dbSNP
rs1056165549	861	dbSNP
rs937636718	870	dbSNP
rs1477380712	871	dbSNP
rs762183257	873	dbSNP
rs151306832	875	dbSNP
rs937816639	876	dbSNP
rs557054208	878	dbSNP
rs1466571089	880	dbSNP
rs1331409061	888	dbSNP
rs1348665397	889	dbSNP
rs1308323510	891	dbSNP
rs1436407088	903	dbSNP
rs1237899110	904	dbSNP
rs1199693729	906	dbSNP
rs1048805111	907	dbSNP
rs781488156	909	dbSNP
rs930377858	916	dbSNP
rs904969310	917	dbSNP
rs1277303491	919	dbSNP
rs1347611026	919	dbSNP
rs920142331	921	dbSNP
rs1216133356	924	dbSNP
rs535180333	926	dbSNP
rs949108243	929	dbSNP
rs148682929	953	dbSNP
rs79041103	953	dbSNP
rs973299808	960	dbSNP
rs1270483037	962	dbSNP
rs1487090169	963	dbSNP
rs1192535970	974	dbSNP
rs973398142	978	dbSNP
rs568685733	983	dbSNP
rs1475915828	985	dbSNP
rs553283294	987	dbSNP
rs912785277	992	dbSNP
rs777023299	993	dbSNP
rs1324260801	994	dbSNP
rs1341376762	994	dbSNP
rs1398265460	994	dbSNP
rs35992969	994	dbSNP
rs398027247	994	dbSNP
rs986778502	995	dbSNP
rs1375723611	998	dbSNP
rs1282281054	1002	dbSNP
rs1309666401	1010	dbSNP
rs1028397102	1013	dbSNP
rs954010437	1017	dbSNP
rs1293283924	1032	dbSNP
rs1392183585	1043	dbSNP
rs1263377522	1046	dbSNP
rs976827829	1053	dbSNP
rs1325215903	1055	dbSNP
rs1028364432	1059	dbSNP
rs979523595	1063	dbSNP
rs1391600869	1069	dbSNP
rs1387661818	1072	dbSNP
rs146133017	1076	dbSNP
rs1158128380	1088	dbSNP
rs1020929076	1089	dbSNP
rs1361407633	1089	dbSNP
rs968528474	1089	dbSNP
rs1468758348	1092	dbSNP
rs1020814410	1096	dbSNP
rs1448521825	1096	dbSNP
rs1317013561	1104	dbSNP
rs1379925246	1113	dbSNP
rs534998337	1117	dbSNP
rs893754562	1127	dbSNP
rs1286186851	1128	dbSNP
rs1352369882	1130	dbSNP
rs1251682841	1133	dbSNP
rs1221531225	1135	dbSNP
rs1009795461	1138	dbSNP
rs1184607319	1139	dbSNP
rs570766349	1147	dbSNP
rs1202889303	1159	dbSNP
rs896420632	1162	dbSNP
rs375685002	1163	dbSNP
rs1352450877	1166	dbSNP
rs1245439050	1169	dbSNP
rs148084589	1178	dbSNP
rs34338532	1178	dbSNP
rs1286356557	1179	dbSNP
rs747485082	1182	dbSNP
rs1178087311	1183	dbSNP
rs1002078720	1193	dbSNP
rs1242045629	1195	dbSNP
rs1455512414	1198	dbSNP
rs184342914	1207	dbSNP
rs1401794321	1209	dbSNP
rs1046581084	1214	dbSNP
rs1274151506	1217	dbSNP
rs1338457516	1222	dbSNP
rs949126887	1226	dbSNP
rs904899079	1227	dbSNP
rs1048751090	1233	dbSNP
rs930440948	1237	dbSNP
rs1336976460	1238	dbSNP
rs1332790584	1247	dbSNP
rs1230471561	1251	dbSNP
rs1273826104	1251	dbSNP
rs193294607	1252	dbSNP
rs1325529342	1254	dbSNP
rs75395215	1262	dbSNP
rs142400637	1269	dbSNP
rs1159550078	1275	dbSNP
rs752877433	1281	dbSNP
rs1198613486	1285	dbSNP
rs1393714168	1287	dbSNP
rs1251907096	1291	dbSNP
rs912819429	1296	dbSNP
rs986971597	1303	dbSNP
rs1191008238	1308	dbSNP
rs1377211363	1308	dbSNP
rs560861885	1309	dbSNP
rs1397900381	1315	dbSNP
rs1464938673	1326	dbSNP
rs1298634191	1337	dbSNP
rs1248972880	1338	dbSNP
rs1384500014	1347	dbSNP
rs1190377729	1357	dbSNP
rs1487712894	1358	dbSNP
rs921296447	1359	dbSNP
rs1345738974	1361	dbSNP
rs979388001	1368	dbSNP
rs76048157	1371	dbSNP
rs1218399017	1374	dbSNP
rs1345322107	1376	dbSNP
rs1277603184	1378	dbSNP
rs921391618	1381	dbSNP
rs1290294250	1383	dbSNP
rs182411413	1387	dbSNP
rs1481907052	1389	dbSNP
rs1346968801	1390	dbSNP
rs540387976	1391	dbSNP
rs113640806	1392	dbSNP
rs1490568020	1392	dbSNP
rs1421791936	1393	dbSNP
rs988005649	1393	dbSNP
rs1374721303	1394	dbSNP
rs960782966	1394	dbSNP
rs1456383671	1395	dbSNP
rs1034849004	1396	dbSNP
rs1268405129	1398	dbSNP
rs1365705744	1398	dbSNP
rs1002157062	1400	dbSNP
rs965461207	1400	dbSNP
rs796983319	1409	dbSNP
rs1299010303	1410	dbSNP
rs1186875658	1411	dbSNP
rs1224839368	1411	dbSNP
rs1243309772	1411	dbSNP
rs1261222308	1411	dbSNP
rs1263647046	1411	dbSNP
rs1265404518	1411	dbSNP
rs1296821247	1411	dbSNP
rs1309763841	1411	dbSNP
rs1360198482	1411	dbSNP
rs1375426692	1411	dbSNP
rs1488125139	1411	dbSNP
rs548865905	1411	dbSNP
rs71127124	1411	dbSNP
rs913959354	1411	dbSNP
rs1384193722	1412	dbSNP
rs1402031709	1415	dbSNP
rs1357678422	1416	dbSNP
rs1316534184	1417	dbSNP
rs1216825786	1418	dbSNP
rs1175718138	1419	dbSNP
rs1181080497	1421	dbSNP
rs1415457863	1423	dbSNP
rs1027348299	1424	dbSNP
rs1446443856	1431	dbSNP
rs142200867	1432	dbSNP
rs1379206763	1435	dbSNP
rs1166700888	1439	dbSNP
rs1419270312	1447	dbSNP
rs1160789133	1448	dbSNP
rs9920623	1449	dbSNP
rs1477194816	1451	dbSNP
rs1423661810	1453	dbSNP
rs1464800428	1453	dbSNP
rs1455103375	1454	dbSNP
rs1195251122	1455	dbSNP
rs897589329	1456	dbSNP
rs1372651917	1457	dbSNP
rs866137571	1462	dbSNP
rs1036489959	1464	dbSNP
rs958024785	1466	dbSNP
rs940203247	1477	dbSNP
rs891331060	1479	dbSNP
rs564343976	1485	dbSNP
rs1051195882	1486	dbSNP
rs932932053	1487	dbSNP
rs1237523338	1492	dbSNP
rs921497780	1494	dbSNP
rs1318550671	1501	dbSNP
rs1422617270	1505	dbSNP
rs1432296480	1506	dbSNP
rs370453654	1512	dbSNP
rs1278881622	1517	dbSNP
rs1220551331	1518	dbSNP
rs979474231	1519	dbSNP
rs572137835	1523	dbSNP
rs367659612	1526	dbSNP
rs1442930263	1530	dbSNP
rs1361308924	1531	dbSNP
rs1365734662	1537	dbSNP
rs1411217658	1538	dbSNP
rs988670840	1539	dbSNP
rs960815145	1541	dbSNP
rs1325365776	1542	dbSNP
rs1216590394	1543	dbSNP
rs1272124924	1544	dbSNP
rs1438394418	1545	dbSNP
rs927812040	1547	dbSNP
rs980583341	1550	dbSNP
rs969314753	1551	dbSNP
rs1027545641	1553	dbSNP
rs1270628146	1554	dbSNP
rs71471510	1556	dbSNP
rs1481589327	1559	dbSNP
rs546104911	1562	dbSNP
rs961973197	1568	dbSNP
rs1172593423	1573	dbSNP
rs1014587139	1575	dbSNP
rs1009095147	1576	dbSNP
rs890189293	1577	dbSNP
rs1051229453	1581	dbSNP
rs553597222	1582	dbSNP
rs1404443018	1590	dbSNP
rs1182126856	1591	dbSNP
rs1024786683	1594	dbSNP
rs900107879	1595	dbSNP
rs1044334484	1596	dbSNP
rs1339969206	1597	dbSNP
rs1013766368	1600	dbSNP
rs8033956	1601	dbSNP
rs913924971	1602	dbSNP
rs1197816947	1604	dbSNP
rs1293406529	1608	dbSNP
rs1052432445	1610	dbSNP
rs1487140938	1611	dbSNP
rs1191465187	1612	dbSNP
rs1241942934	1613	dbSNP
rs939439390	1616	dbSNP
rs1458108896	1618	dbSNP
rs1383946297	1621	dbSNP
rs556681579	1624	dbSNP
rs1164371065	1627	dbSNP
rs545355301	1627	dbSNP
rs1418154423	1632	dbSNP
rs1320036819	1634	dbSNP
rs887409668	1635	dbSNP
rs980611230	1637	dbSNP
rs969175352	1638	dbSNP
rs920523614	1642	dbSNP
rs1351017165	1643	dbSNP
rs1381659052	1654	dbSNP
rs973769654	1657	dbSNP
rs1447890879	1660	dbSNP
rs1218396907	1662	dbSNP
rs541949875	1667	dbSNP
rs1444625605	1670	dbSNP
rs1446523032	1671	dbSNP
rs1401641787	1672	dbSNP
rs1184264188	1676	dbSNP
rs1387204655	1678	dbSNP
rs1015034630	1680	dbSNP
rs1008546270	1681	dbSNP
rs954480659	1682	dbSNP
rs1402164077	1683	dbSNP
rs1028671856	1686	dbSNP
rs921443999	1687	dbSNP
rs996979171	1691	dbSNP
rs1316491446	1698	dbSNP
rs1373960009	1709	dbSNP
rs1164891717	1713	dbSNP
rs944183372	1723	dbSNP
rs1406704484	1724	dbSNP
rs1378107642	1727	dbSNP
rs1225819683	1731	dbSNP
rs1177719804	1733	dbSNP
rs1261716247	1747	dbSNP
rs914031272	1749	dbSNP
rs1440147797	1753	dbSNP
rs34839126	1755	dbSNP
rs1239898709	1757	dbSNP
rs899972129	1761	dbSNP
rs988626519	1761	dbSNP
rs1436096689	1767	dbSNP
rs35173182	1767	dbSNP
rs1189449713	1770	dbSNP
rs958034649	1774	dbSNP
rs1471311894	1777	dbSNP
rs1173957048	1781	dbSNP
rs1043892307	1783	dbSNP
rs772127942	1784	dbSNP
rs1273009097	1799	dbSNP
rs1390242815	1823	dbSNP
rs1337140490	1825	dbSNP
rs1011603707	1826	dbSNP
rs892699138	1829	dbSNP
rs144456642	1831	dbSNP
rs969265867	1850	dbSNP
rs12905720	1853	dbSNP
rs1284212200	1855	dbSNP
rs1013443327	1856	dbSNP
rs1378165002	1861	dbSNP
rs1439741155	1871	dbSNP
rs962177618	1872	dbSNP
rs1268473512	1874	dbSNP
rs185397323	1881	dbSNP
rs1005885802	1882	dbSNP
rs866170200	1890	dbSNP
rs1461466077	1896	dbSNP
rs556260874	1901	dbSNP
rs1367560674	1903	dbSNP
rs1050019294	1911	dbSNP
rs1459008938	1914	dbSNP
rs1397962561	1916	dbSNP
rs1402585958	1918	dbSNP
rs1302082969	1929	dbSNP
rs1345760788	1933	dbSNP
rs1405933831	1937	dbSNP
rs1358220157	1944	dbSNP
rs570828015	1950	dbSNP
rs1341498982	1952	dbSNP
rs995782996	1955	dbSNP
rs1201289933	1960	dbSNP
rs900103752	1963	dbSNP
rs371366425	1966	dbSNP
rs1193749137	1967	dbSNP
rs192043712	1968	dbSNP
rs1381879830	1975	dbSNP
rs1173726659	1977	dbSNP
rs1162454208	1981	dbSNP
rs944256580	1987	dbSNP
rs1426212484	1991	dbSNP
rs78122915	1992	dbSNP
rs1267988893	1993	dbSNP
rs773796086	1997	dbSNP
rs1382030735	2000	dbSNP
rs907762782	2009	dbSNP
rs987111967	2017	dbSNP
rs1367981087	2032	dbSNP
rs954345774	2041	dbSNP
rs1314527530	2054	dbSNP
rs187232150	2055	dbSNP
rs1224960123	2062	dbSNP
rs974499210	2064	dbSNP
rs139823709	2067	dbSNP
rs936716177	2068	dbSNP
rs968425462	2070	dbSNP
rs1263760699	2074	dbSNP
rs1022908319	2084	dbSNP
rs1011050740	2097	dbSNP
rs1385356238	2098	dbSNP
rs892722325	2104	dbSNP
rs1445954041	2110	dbSNP
rs201941563	2111	dbSNP
rs1031217183	2112	dbSNP
rs1003545469	2117	dbSNP
rs1312068610	2124	dbSNP
rs917874347	2126	dbSNP
rs1289884826	2142	dbSNP
rs1302659755	2142	dbSNP
rs906569063	2148	dbSNP
rs762761505	2149	dbSNP
rs948148849	2157	dbSNP
rs1388008415	2158	dbSNP
rs899230485	2159	dbSNP
rs1239491050	2163	dbSNP
rs1269844724	2173	dbSNP
rs1297063814	2174	dbSNP
rs1243695528	2175	dbSNP
rs1462219504	2182	dbSNP
rs1174977326	2188	dbSNP
rs1037958718	2193	dbSNP
rs940508490	2201	dbSNP
rs530220275	2202	dbSNP
rs1414596690	2209	dbSNP
rs1468588722	2214	dbSNP
rs987310610	2227	dbSNP
rs933235981	2230	dbSNP
rs1336584395	2232	dbSNP
rs984517278	2236	dbSNP
rs1450295778	2242	dbSNP
rs182526750	2245	dbSNP
rs1028679940	2246	dbSNP
rs1491503275	2246	dbSNP
rs1491455487	2247	dbSNP
rs1178194005	2249	dbSNP
rs1263609152	2256	dbSNP
rs769669668	2269	dbSNP
rs1201808815	2270	dbSNP
rs1231859402	2272	dbSNP
rs1480691812	2281	dbSNP
rs1481447998	2283	dbSNP
rs995835357	2283	dbSNP
rs771517654	2285	dbSNP
rs1266349746	2295	dbSNP
rs1176247293	2305	dbSNP
rs778161080	2305	dbSNP
rs1416705369	2309	dbSNP
rs1430594918	2309	dbSNP
rs189854496	2310	dbSNP
rs1021344648	2312	dbSNP
rs990061147	2318	dbSNP
rs1462578066	2322	dbSNP
rs558058356	2326	dbSNP
rs1310023459	2331	dbSNP
rs1343874952	2341	dbSNP
rs956854031	2344	dbSNP
rs1031170764	2348	dbSNP
rs1283751770	2351	dbSNP
rs1369614208	2354	dbSNP
rs1212775281	2357	dbSNP
rs1008859288	2361	dbSNP
rs892654860	2364	dbSNP
rs1052578278	2366	dbSNP
rs1289136361	2372	dbSNP
rs1490101964	2373	dbSNP
rs1199125425	2382	dbSNP
rs936810925	2392	dbSNP
rs1479224831	2394	dbSNP
rs747919722	2402	dbSNP
rs1003833450	2407	dbSNP
rs528329512	2408	dbSNP
rs1483168547	2410	dbSNP
rs781199578	2411	dbSNP
rs1363927475	2416	dbSNP
rs1303500008	2418	dbSNP
rs1424316657	2418	dbSNP
rs1351356601	2422	dbSNP
rs1257073862	2425	dbSNP
rs761517067	2426	dbSNP
rs564251893	2429	dbSNP
rs903963228	2431	dbSNP
rs1045171046	2433	dbSNP
rs899260163	2443	dbSNP
rs1037757546	2444	dbSNP
rs940522519	2445	dbSNP
rs1453622655	2446	dbSNP
rs1313809889	2449	dbSNP
rs886313400	2449	dbSNP
rs1450700830	2454	dbSNP
rs1190568101	2459	dbSNP
rs1383512166	2460	dbSNP
rs1398737444	2460	dbSNP
rs35412000	2460	dbSNP
rs5812525	2460	dbSNP
rs66850273	2460	dbSNP
rs796498481	2460	dbSNP
rs1316625034	2461	dbSNP
rs62017258	2461	dbSNP
rs1317451496	2462	dbSNP
rs552552888	2469	dbSNP
rs530706767	2475	dbSNP
rs1341974218	2482	dbSNP
rs984610634	2485	dbSNP
rs1246086064	2488	dbSNP
rs1285519988	2489	dbSNP
rs12904729	2492	dbSNP
rs921827280	2496	dbSNP
rs1465718968	2498	dbSNP
rs572124295	2505	dbSNP
rs1211080153	2512	dbSNP
rs1038688564	2513	dbSNP
rs1241849656	2523	dbSNP
rs1304397557	2539	dbSNP
rs947037233	2556	dbSNP
rs747245789	2560	dbSNP
rs541415815	2574	dbSNP
rs955972105	2575	dbSNP
rs924137266	2587	dbSNP
rs139081501	2588	dbSNP
rs558992168	2589	dbSNP
rs1452718754	2591	dbSNP
rs1023866135	2593	dbSNP
rs892740419	2598	dbSNP
rs1012670316	2604	dbSNP
rs534558216	2616	dbSNP
rs375331854	2630	dbSNP
rs577048341	2631	dbSNP
rs903987936	2633	dbSNP
rs1016675674	2634	dbSNP
rs1045175476	2640	dbSNP
rs1323520027	2641	dbSNP
rs9920083	2642	dbSNP
rs12437783	2648	dbSNP
rs1456779159	2656	dbSNP
rs1258043564	2659	dbSNP
rs1473409827	2667	dbSNP
rs1198722114	2669	dbSNP
rs1056894253	2679	dbSNP
rs1428499061	2681	dbSNP
rs1051563739	2686	dbSNP
rs1340910966	2687	dbSNP
rs940682079	2690	dbSNP
rs997274637	2691	dbSNP
rs12437770	2693	dbSNP
rs186965691	2700	dbSNP
rs368974587	2705	dbSNP
rs1281831784	2708	dbSNP
rs28693855	2717	dbSNP
rs921732029	2723	dbSNP
rs1314528257	2729	dbSNP
rs536223561	2730	dbSNP
rs776272003	2730	dbSNP
rs12437803	2731	dbSNP
rs747394158	2732	dbSNP
rs751257518	2732	dbSNP
rs988907696	2733	dbSNP
rs1376049831	2734	dbSNP
rs1267965308	2735	dbSNP
rs778324646	2735	dbSNP
rs1200849285	2739	dbSNP
rs1371279705	2751	dbSNP
rs955730086	2754	dbSNP
rs934452277	2758	dbSNP
rs1168742663	2768	dbSNP
rs1371999353	2773	dbSNP
rs1422408110	2787	dbSNP
rs928347366	2794	dbSNP
rs1031293070	2803	dbSNP
rs1161564762	2811	dbSNP
rs114076583	2816	dbSNP
rs1303972222	2827	dbSNP
rs968226435	2828	dbSNP
rs1226761793	2829	dbSNP
rs1298481388	2832	dbSNP
rs1344545001	2834	dbSNP
rs1220482565	2841	dbSNP
rs1023779349	2843	dbSNP
rs970852377	2847	dbSNP
rs896585955	2851	dbSNP
rs1056547952	2855	dbSNP
rs1005325139	2866	dbSNP
rs1391441860	2867	dbSNP
rs1271424491	2874	dbSNP
rs1442266656	2875	dbSNP
rs886410843	2876	dbSNP
rs1438301391	2889	dbSNP
rs1216273654	2898	dbSNP
rs1238068337	2903	dbSNP
rs916838804	2911	dbSNP
rs1440081261	2913	dbSNP
rs1048972004	2924	dbSNP
rs758872969	2926	dbSNP
rs1287084726	2930	dbSNP
rs991126530	2938	dbSNP
rs963958545	2952	dbSNP
rs1016289521	2956	dbSNP
rs1367381537	2961	dbSNP
rs140464379	2970	dbSNP
rs1356541670	2973	dbSNP
rs1312196184	2985	dbSNP
rs1005269511	2989	dbSNP
rs765759297	2990	dbSNP
rs1030338797	2994	dbSNP
rs997305261	3001	dbSNP
rs1249837800	3004	dbSNP
rs539133374	3008	dbSNP
rs549904218	3011	dbSNP
rs762503400	3012	dbSNP
rs1459540117	3021	dbSNP
rs1182522532	3023	dbSNP
rs1256400935	3027	dbSNP
rs1309865394	3038	dbSNP
rs1425235399	3041	dbSNP
rs1167306043	3058	dbSNP
rs1362380684	3066	dbSNP
rs1444243358	3067	dbSNP
rs1457064123	3068	dbSNP
rs1160480838	3069	dbSNP
rs570700319	3070	dbSNP
rs531166874	3075	dbSNP
rs911670667	3084	dbSNP
rs1302384828	3085	dbSNP
rs988571430	3087	dbSNP
rs1011519873	3090	dbSNP
rs1305163145	3091	dbSNP
rs893027258	3094	dbSNP
rs147220346	3100	dbSNP
rs1293566663	3106	dbSNP
rs979692850	3108	dbSNP
rs1321405652	3112	dbSNP
rs1208793728	3116	dbSNP
rs1256119857	3119	dbSNP
rs772638390	3130	dbSNP
rs182530864	3132	dbSNP
rs548835201	3141	dbSNP
rs115716886	3147	dbSNP
rs1249401514	3150	dbSNP
rs1472430937	3151	dbSNP
rs1023869038	3152	dbSNP
rs1414806469	3155	dbSNP
rs1045470219	3156	dbSNP
rs1159663713	3160	dbSNP
rs948449557	3164	dbSNP
rs1471404498	3172	dbSNP
rs916784897	3173	dbSNP
rs1197538819	3176	dbSNP
rs1296596774	3180	dbSNP
rs1350170567	3181	dbSNP
rs1410189638	3186	dbSNP
rs991383964	3191	dbSNP
rs960894618	3194	dbSNP
rs942315267	3199	dbSNP
rs529693482	3204	dbSNP
rs748692605	3205	dbSNP
rs1218536059	3212	dbSNP
rs1035521174	3213	dbSNP
rs1313383434	3223	dbSNP
rs1214065113	3233	dbSNP
rs1273460372	3241	dbSNP
rs1352565592	3245	dbSNP
rs192430260	3246	dbSNP
rs1254367312	3247	dbSNP
rs950679679	3249	dbSNP
rs1191063513	3251	dbSNP
rs1225266544	3253	dbSNP
rs1342765410	3256	dbSNP
rs1274252518	3257	dbSNP
rs1232579441	3258	dbSNP
rs1168492677	3270	dbSNP
rs1370165624	3270	dbSNP
rs535368305	3270	dbSNP
rs1346284407	3284	dbSNP
rs1363434332	3291	dbSNP
rs1030284977	3303	dbSNP
rs1275303679	3305	dbSNP
rs1369723659	3316	dbSNP
rs1049023885	3319	dbSNP
rs1212282821	3327	dbSNP
rs1296282969	3328	dbSNP
rs1342292469	3331	dbSNP
rs1230093638	3334	dbSNP
rs755118745	3340	dbSNP
rs1289155490	3343	dbSNP
rs994786238	3344	dbSNP
rs1221377185	3347	dbSNP
rs1333970022	3349	dbSNP
rs976169872	3363	dbSNP
rs1247783159	3364	dbSNP
rs1489780333	3377	dbSNP
rs187090751	3386	dbSNP
rs900451285	3387	dbSNP
rs970296554	3388	dbSNP
rs1038948965	3393	dbSNP
rs964750082	3406	dbSNP
rs540771009	3411	dbSNP
rs1398341711	3415	dbSNP
rs1383624864	3417	dbSNP
rs944571953	3420	dbSNP
rs1017459177	3427	dbSNP
rs1011803451	3430	dbSNP
rs1022761370	3432	dbSNP
rs1255403150	3435	dbSNP
rs893067552	3436	dbSNP
rs1402869051	3437	dbSNP
rs1428504625	3437	dbSNP
rs1319832302	3439	dbSNP
rs1423685785	3439	dbSNP
rs1172549628	3455	dbSNP
rs1478059649	3457	dbSNP
rs1053297657	3458	dbSNP
rs1228081107	3458	dbSNP
rs1309351761	3458	dbSNP
rs200091177	3458	dbSNP
rs34242636	3458	dbSNP
rs71127122	3458	dbSNP
rs1273725221	3459	dbSNP
rs1214238839	3460	dbSNP
rs1430734512	3461	dbSNP
rs1190880130	3464	dbSNP
rs1487722185	3465	dbSNP
rs1263525031	3467	dbSNP
rs1217669318	3470	dbSNP
rs182055020	3471	dbSNP
rs1334173890	3472	dbSNP
rs1339474850	3476	dbSNP
rs1031974896	3480	dbSNP
rs1277800108	3482	dbSNP
rs1285620785	3484	dbSNP
rs576518964	3497	dbSNP
rs906908112	3499	dbSNP
rs1268048396	3502	dbSNP
rs1210645754	3508	dbSNP
rs1276540808	3517	dbSNP
rs1441938178	3521	dbSNP
rs565144690	3526	dbSNP
rs1045417330	3527	dbSNP
rs12900430	3528	dbSNP
rs190348406	3533	dbSNP
rs894191964	3534	dbSNP
rs185488293	3535	dbSNP
rs942158121	3536	dbSNP
rs1458788775	3538	dbSNP
rs1357840867	3546	dbSNP
rs528055147	3550	dbSNP
rs572520592	3554	dbSNP
rs1470548995	3565	dbSNP
rs1400819975	3581	dbSNP
rs929550470	3600	dbSNP
rs148091860	3601	dbSNP
rs1352470020	3602	dbSNP
rs961165128	3603	dbSNP
rs1035173457	3609	dbSNP
rs1351608788	3612	dbSNP
rs539145927	3621	dbSNP
rs1230722473	3622	dbSNP
rs766575082	3623	dbSNP
rs571723651	3628	dbSNP
rs552426000	3629	dbSNP
rs1018078841	3630	dbSNP
rs1423855917	3633	dbSNP
rs990008951	3640	dbSNP
rs1187947862	3641	dbSNP
rs1280976064	3645	dbSNP
rs1482223160	3654	dbSNP
rs1471618960	3659	dbSNP
rs1252218558	3660	dbSNP
rs957395772	3664	dbSNP
rs1031501478	3665	dbSNP
rs1377005988	3666	dbSNP
rs1478068858	3670	dbSNP
rs950833196	3672	dbSNP
rs1027677350	3676	dbSNP
rs1210566488	3678	dbSNP
rs998808208	3682	dbSNP
rs1371496970	3683	dbSNP
rs143649240	3686	dbSNP
rs1471959002	3687	dbSNP
rs1024001812	3689	dbSNP
rs1017947834	3695	dbSNP
rs1196826297	3705	dbSNP
rs1317419172	3706	dbSNP
rs1234026469	3710	dbSNP
rs1012558204	3718	dbSNP
rs1276724659	3726	dbSNP
rs1340169625	3729	dbSNP
rs894233795	3730	dbSNP
rs369999204	3736	dbSNP
rs1273950710	3738	dbSNP
rs1008791483	3744	dbSNP
rs757059916	3747	dbSNP
rs890298576	3755	dbSNP
rs1052985373	3757	dbSNP
rs1200333940	3757	dbSNP
rs1038487654	3761	dbSNP
rs1216501847	3780	dbSNP
rs1005298311	3783	dbSNP
rs887975697	3786	dbSNP
rs1463838772	3796	dbSNP
rs181357731	3797	dbSNP
rs1283908039	3801	dbSNP
rs929581441	3818	dbSNP
rs1328540507	3819	dbSNP
rs1042819385	3820	dbSNP
rs1329955444	3823	dbSNP
rs1298605305	3825	dbSNP
rs948372981	3837	dbSNP
rs923499615	3843	dbSNP
rs1242312583	3849	dbSNP
rs113200641	3852	dbSNP
rs1235489363	3859	dbSNP
rs1211514768	3860	dbSNP
rs529996649	3869	dbSNP
rs1354562964	3874	dbSNP
rs1171943407	3876	dbSNP
rs991499781	3888	dbSNP
rs1249476486	3892	dbSNP
rs565374676	3893	dbSNP
rs943341548	3899	dbSNP
rs910641590	3901	dbSNP
rs1186433753	3902	dbSNP
rs1368205303	3904	dbSNP
rs990679220	3905	dbSNP
rs957470541	3910	dbSNP
rs924469273	3915	dbSNP
rs977234478	3932	dbSNP
rs928194840	3935	dbSNP
rs983609565	3937	dbSNP
rs971316224	3941	dbSNP
rs1024194533	3953	dbSNP
rs1177995709	3961	dbSNP
rs546945967	3966	dbSNP
rs1394471613	3980	dbSNP
rs1458179615	3983	dbSNP
rs973426388	3986	dbSNP
rs149389064	3988	dbSNP
rs1234979874	3990	dbSNP
rs532079378	3993	dbSNP
rs1017575026	3994	dbSNP
rs1208773148	3996	dbSNP
rs1269432581	4003	dbSNP
rs1481999985	4004	dbSNP
rs1180858009	4005	dbSNP
rs138792521	4007	dbSNP
rs1424759110	4009	dbSNP
rs372527344	4011	dbSNP
rs1190591515	4021	dbSNP
rs890401841	4022	dbSNP
rs1410375162	4027	dbSNP
rs1472575145	4030	dbSNP
rs1206728651	4047	dbSNP
rs958654014	4048	dbSNP
rs1464622136	4049	dbSNP
rs1289512622	4055	dbSNP
rs1016591032	4059	dbSNP
rs1247130482	4061	dbSNP
rs1403249096	4063	dbSNP
rs544009635	4065	dbSNP
rs998719976	4066	dbSNP
rs751359896	4067	dbSNP
rs1005740809	4074	dbSNP
rs1362097645	4084	dbSNP
rs1228878238	4085	dbSNP
rs1309071535	4096	dbSNP
rs904320936	4121	dbSNP
rs1208899715	4130	dbSNP
rs1486478662	4141	dbSNP
rs1307559328	4143	dbSNP
rs188512894	4144	dbSNP
rs1047900698	4149	dbSNP
rs145032242	4150	dbSNP
rs1482947408	4155	dbSNP
rs1183463207	4160	dbSNP
rs1433748680	4162	dbSNP
rs894147709	4164	dbSNP
rs1056830464	4169	dbSNP
rs938330782	4172	dbSNP
rs928277804	4178	dbSNP
rs902113505	4181	dbSNP
rs1378201026	4184	dbSNP
rs1157864820	4185	dbSNP
rs1306423001	4192	dbSNP
rs1369652302	4193	dbSNP
rs1419536613	4194	dbSNP
rs1252648941	4197	dbSNP
rs1040566226	4200	dbSNP
rs1365478383	4206	dbSNP
rs943633093	4207	dbSNP
rs1047959781	4210	dbSNP
rs1301414470	4212	dbSNP
rs910578362	4213	dbSNP
rs1054449524	4222	dbSNP
rs184620435	4224	dbSNP
rs924666915	4226	dbSNP
rs977260458	4229	dbSNP
rs1273486347	4231	dbSNP
rs1482896005	4232	dbSNP
rs1223440384	4234	dbSNP
rs920724553	4245	dbSNP
rs973470933	4246	dbSNP
rs1455649278	4248	dbSNP
rs971181406	4249	dbSNP
rs917084273	4257	dbSNP
rs200076768	4258	dbSNP
rs910608046	4274	dbSNP
rs987528127	4278	dbSNP
rs1284238780	4284	dbSNP
rs954864494	4290	dbSNP
rs8037489	4292	dbSNP
rs1017034508	4293	dbSNP
rs1309869748	4295	dbSNP
rs113854708	4297	dbSNP
rs1215491949	4302	dbSNP
rs968556604	4307	dbSNP
rs1273324263	4311	dbSNP
rs1221398468	4317	dbSNP
rs1274357008	4327	dbSNP
rs1469872447	4328	dbSNP
rs1186824174	4334	dbSNP
rs1021440876	4335	dbSNP
rs112117620	4338	dbSNP
rs1188542084	4346	dbSNP
rs1406357452	4349	dbSNP
rs1404565686	4350	dbSNP
rs1358239040	4351	dbSNP
rs1396689364	4352	dbSNP
rs12913464	4355	dbSNP
rs1454177506	4357	dbSNP
rs1319348709	4371	dbSNP
rs1365433112	4373	dbSNP
rs1282077194	4385	dbSNP
rs1377339868	4390	dbSNP
rs1228174433	4395	dbSNP
rs12913733	4398	dbSNP
rs1432543571	4399	dbSNP
rs1428633948	4403	dbSNP
rs1200237209	4406	dbSNP
rs1481508485	4407	dbSNP
rs1261373626	4417	dbSNP
rs1444919936	4418	dbSNP
rs1354617992	4419	dbSNP
rs1486421823	4432	dbSNP
rs1419900531	4433	dbSNP
rs1262997040	4434	dbSNP
rs1208583513	4435	dbSNP
rs1312157870	4436	dbSNP
rs1169080899	4437	dbSNP
rs1224839175	4438	dbSNP
rs1407879286	4439	dbSNP
rs201910972	4440	dbSNP
rs1165155284	4441	dbSNP
rs71397505	4442	dbSNP
rs1491091833	4443	dbSNP
rs1170350940	4444	dbSNP
rs1196710672	4444	dbSNP
rs1273109331	4444	dbSNP
rs1307958815	4444	dbSNP
rs1314359018	4444	dbSNP
rs1336933710	4444	dbSNP
rs1364377507	4444	dbSNP
rs1377593695	4444	dbSNP
rs1408392613	4444	dbSNP
rs1423995600	4444	dbSNP
rs1434911464	4444	dbSNP
rs1470870201	4444	dbSNP
rs1491467575	4444	dbSNP
rs57967778	4444	dbSNP
rs61674724	4444	dbSNP
rs1386804637	4445	dbSNP
rs1454347279	4445	dbSNP
rs1167751237	4446	dbSNP
rs1175056069	4446	dbSNP
rs1388010374	4446	dbSNP
rs1393595683	4446	dbSNP
rs1397693503	4446	dbSNP
rs1428207142	4446	dbSNP
rs1322160343	4447	dbSNP
rs1207933341	4448	dbSNP
rs1227360739	4448	dbSNP
rs1251636917	4448	dbSNP
rs1289066007	4448	dbSNP
rs1305878835	4448	dbSNP
rs1363346691	4448	dbSNP
rs1370251528	4448	dbSNP
rs1441818869	4448	dbSNP
rs866222210	4449	dbSNP
rs1193481251	4450	dbSNP
rs1195020629	4450	dbSNP
rs1245795513	4450	dbSNP
rs1337979534	4450	dbSNP
rs1373936565	4450	dbSNP
rs1454029668	4450	dbSNP
rs1463856616	4450	dbSNP
rs1386587268	4451	dbSNP
rs375533719	4451	dbSNP
rs1327915337	4452	dbSNP
rs1242424963	4453	dbSNP
rs28672106	4453	dbSNP
rs1185926899	4454	dbSNP
rs1205284770	4454	dbSNP
rs1214985323	4454	dbSNP
rs1263492650	4454	dbSNP
rs1265641228	4454	dbSNP
rs1417734221	4454	dbSNP
rs1430645833	4454	dbSNP
rs1464059259	4454	dbSNP
rs1167770462	4455	dbSNP
rs1320826359	4455	dbSNP
rs1453155408	4455	dbSNP
rs1475799151	4455	dbSNP
rs372730782	4455	dbSNP
rs1312096229	4456	dbSNP
rs1387492518	4456	dbSNP
rs1394046910	4456	dbSNP
rs1234999397	4457	dbSNP
rs1286384503	4457	dbSNP
rs1315808101	4457	dbSNP
rs1355876676	4457	dbSNP
rs1239203781	4458	dbSNP
rs1262097198	4458	dbSNP
rs1482092512	4458	dbSNP
rs1199552004	4459	dbSNP
rs1257198350	4459	dbSNP
rs1486213084	4459	dbSNP
rs1159988867	4460	dbSNP
rs1190618153	4460	dbSNP
rs1410490659	4460	dbSNP
rs1418564532	4460	dbSNP
rs1173261411	4461	dbSNP
rs1365725820	4461	dbSNP
rs200906062	4461	dbSNP
rs1375760701	4462	dbSNP
rs1465423475	4462	dbSNP
rs1306088440	4463	dbSNP
rs1406748593	4463	dbSNP
rs71127121	4463	dbSNP
rs1372584599	4464	dbSNP
rs1177226600	4465	dbSNP
rs1481498558	4467	dbSNP
rs180787756	4469	dbSNP
rs1233038856	4471	dbSNP
rs1403807119	4471	dbSNP
rs1280605639	4473	dbSNP
rs1213543977	4475	dbSNP
rs1250226558	4475	dbSNP
rs1349045066	4475	dbSNP
rs376948410	4475	dbSNP
rs1166525057	4476	dbSNP
rs1353738320	4477	dbSNP
rs1421716367	4479	dbSNP
rs1192809833	4481	dbSNP
rs1429362647	4483	dbSNP
rs1002577975	4490	dbSNP
rs1439610389	4494	dbSNP
rs1180488297	4500	dbSNP
rs1461218332	4509	dbSNP
rs886741459	4516	dbSNP
rs1204979433	4517	dbSNP
rs1307309472	4520	dbSNP
rs1047970795	4534	dbSNP
rs1253663622	4545	dbSNP
rs1467181373	4549	dbSNP
rs1193137464	4553	dbSNP
rs1253832619	4554	dbSNP
rs1250290184	4555	dbSNP
rs753160890	4556	dbSNP
rs569801020	4563	dbSNP
rs1455715115	4565	dbSNP
rs1327835064	4566	dbSNP
rs1052452	4569	dbSNP
rs1418455618	4571	dbSNP
rs1310241739	4573	dbSNP
rs1428902784	4580	dbSNP
rs1172443724	4597	dbSNP
rs1395299756	4610	dbSNP
rs1348113457	4613	dbSNP
rs1460449851	4620	dbSNP
rs1326047998	4628	dbSNP
rs1396076359	4630	dbSNP
rs1432380623	4633	dbSNP
rs12442197	4635	dbSNP
rs920831658	4640	dbSNP
rs1132238	4642	dbSNP
rs1215580638	4654	dbSNP
rs1298338378	4656	dbSNP
rs1338667834	4661	dbSNP
rs1333387484	4673	dbSNP
rs1213653250	4677	dbSNP
rs190724766	4680	dbSNP
rs1132239	4703	dbSNP
rs745925887	4720	dbSNP
rs372347714	4736	dbSNP
rs902061103	4750	dbSNP
rs1019063647	4757	dbSNP
rs1241814835	4764	dbSNP
rs1475611987	4766	dbSNP
rs1008255214	4777	dbSNP
rs1415546569	4778	dbSNP
rs1176682047	4782	dbSNP
rs954733941	4791	dbSNP
rs1375020593	4794	dbSNP
rs1163110158	4795	dbSNP
rs1317176551	4803	dbSNP
rs1455246875	4803	dbSNP
rs1345465446	4814	dbSNP
rs889358608	4825	dbSNP
rs111389708	4827	dbSNP
rs547012951	4837	dbSNP
rs903270365	4842	dbSNP
rs142509284	4856	dbSNP
rs12908546	4865	dbSNP
rs1337037636	4867	dbSNP
rs1012794291	4869	dbSNP
rs1283800792	4875	dbSNP
rs958778114	4885	dbSNP
rs1341019382	4889	dbSNP
rs917113577	4897	dbSNP
rs142314952	4903	dbSNP
rs1485231201	4907	dbSNP
rs549657456	4911	dbSNP
rs1359949979	4916	dbSNP
rs1316925886	4933	dbSNP
rs185421096	4935	dbSNP
rs369503004	4941	dbSNP
rs1223207428	4943	dbSNP
rs1402033877	4945	dbSNP
rs995114655	4947	dbSNP
rs909770139	4952	dbSNP
rs374582524	4953	dbSNP
rs951042771	4963	dbSNP
rs1398865567	4968	dbSNP
rs1038350143	4969	dbSNP
rs1357968751	4979	dbSNP
rs754351492	4992	dbSNP
rs1161724863	4998	dbSNP
rs1278997382	5000	dbSNP
rs1351527045	5012	dbSNP
rs1424285367	5013	dbSNP
rs543158725	5016	dbSNP
rs1386206704	5024	dbSNP
rs1346859033	5025	dbSNP
rs1211390064	5029	dbSNP
rs1282338282	5035	dbSNP
rs1435963991	5040	dbSNP
rs1181027013	5056	dbSNP
rs528012152	5062	dbSNP
rs770541928	5071	dbSNP
rs80222669	5081	dbSNP
rs1438318436	5084	dbSNP
rs889241994	5087	dbSNP
rs1191354152	5088	dbSNP
rs1394163384	5091	dbSNP
rs1363783551	5095	dbSNP
rs1051872975	5104	dbSNP
rs1174703145	5115	dbSNP
rs1319493785	5120	dbSNP
rs1019095504	5122	dbSNP
rs1052457	5128	dbSNP
rs1328791935	5129	dbSNP
rs1336360179	5130	dbSNP
rs1233547114	5131	dbSNP
rs1301495607	5148	dbSNP
rs1444524479	5148	dbSNP
rs1370577019	5158	dbSNP
rs889380640	5161	dbSNP
rs1337218330	5162	dbSNP
rs1033224943	5170	dbSNP
rs756493233	5174	dbSNP
rs1052459	5183	dbSNP
rs1221215106	5189	dbSNP
rs903218111	5195	dbSNP
rs1439030770	5196	dbSNP
rs1211333692	5201	dbSNP
rs1490421071	5203	dbSNP
rs1041726970	5212	dbSNP
rs556521321	5216	dbSNP
rs950135164	5224	dbSNP
rs895877109	5234	dbSNP
rs1379679221	5244	dbSNP
rs1237707605	5248	dbSNP
rs1349859063	5250	dbSNP
rs544422967	5253	dbSNP
rs1056046536	5255	dbSNP
rs1167842764	5258	dbSNP
rs1397891925	5276	dbSNP
rs574041781	5281	dbSNP
rs1467218492	5286	dbSNP
rs1323921456	5289	dbSNP
rs1393856096	5295	dbSNP
rs1280138500	5299	dbSNP
rs1303683296	5301	dbSNP
rs947369682	5314	dbSNP
rs937154824	5325	dbSNP
rs1337557829	5328	dbSNP
rs1270675701	5330	dbSNP
rs1341437864	5330	dbSNP
rs1301403513	5337	dbSNP
rs1231410736	5341	dbSNP
rs1271938982	5344	dbSNP
rs1468552194	5350	dbSNP
rs772504451	5353	dbSNP
rs909794161	5361	dbSNP
rs1215106495	5363	dbSNP
rs984096402	5368	dbSNP
rs929890417	5374	dbSNP
rs1404489916	5376	dbSNP
rs1366440372	5383	dbSNP
rs1445612418	5396	dbSNP
rs918283248	5402	dbSNP
rs1192965534	5423	dbSNP
rs10467	5426	dbSNP
rs376872074	5430	dbSNP
rs965119628	5432	dbSNP
rs28521363	5439	dbSNP
rs986706111	5442	dbSNP
rs1295490252	5453	dbSNP
rs1035910628	5455	dbSNP
rs1318680852	5455	dbSNP
rs1471455260	5469	dbSNP
rs1342170049	5470	dbSNP
rs981229017	5479	dbSNP
rs1292607689	5484	dbSNP
rs1198076449	5486	dbSNP
rs951157006	5488	dbSNP
rs1480528343	5497	dbSNP
rs1270674629	5505	dbSNP
rs148440227	5507	dbSNP
rs1205374399	5512	dbSNP
rs1262792335	5518	dbSNP
rs1033587571	5519	dbSNP
rs1000480467	5523	dbSNP
rs967602774	5524	dbSNP

- Nature methods, 2011

Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.

- Genome biology, 2014

BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.