miRTarBase - #MIRT501054


—
pre-miRNA Information
pre-miRNA hsa-mir-4491   
Genomic Coordinates chr11: 111347757 - 111347824
Description Homo sapiens miR-4491 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4491
Sequence 46| AAUGUGGACUGGUGUGACCAAA |67
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1043555759 4 dbSNP
rs1182248607 6 dbSNP
rs527936256 7 dbSNP
rs755554417 14 dbSNP
rs779628583 16 dbSNP
rs1471408223 19 dbSNP
rs909066815 20 dbSNP
Putative Targets

Gene Information
Gene Symbol SMCR8   
Synonyms -
Description Smith-Magenis syndrome chromosome region, candidate 8
Transcript NM_144775   
Expression
Putative miRNA Targets on SMCR8
3'UTR of SMCR8
(miRNA target sites are highlighted)		 
>SMCR8|NM_144775|3'UTR
   1 GGTCGGTCCCAGACACTGTGACCAAGACCTGTGACTCAGGGTATGGGGAGGGGAGGGGTTGGCATGACCAAACAGTTGCC
  81 TGAGCTGGACTGTTTAAGTTTCTGGTGTCTGGCAGCATGGTTCCCACGTGGCTCCTAGTAGTTTTTAAGTTGGACATGGG
 161 CAGAAGTGGAGCCTGGCTCCCTCTAAAGGCGTCTGGAGGGATGGTGACAGCTACATTTGGCTCCCTGGTGAAGAGTGGCC
 241 CCTGGATATGGAGGGGGCCTTGGTTTTCTGAGGACTGGCAGCCAGGGCAGAAGGGAAGCCACCAGTCCCTTGGTGGGGCA
 321 GGGTGAGGGCAGGAAGGCCAAAGCCTGATGGGAGGAGCACACTGGCTGTATTCAGCATTGCCGGACACTTGAGTGGCAAA
 401 ATGAACGAGGGTGACAGCCAGGTAACTGTTGTGGTTTGGTGGAAAACAGGAGGGCAGAACACCCATCGCCTCCTTCAGAC
 481 CCAGATGCAGCCCTTTATTTGCTTCCTGGAGCCCACTGTCCTAGGGGAGGCCCTGGACCAGCCAGTGGGGGTGAGAAAGG
 561 CTGCCACCCTCTGGGTCGTGGGAAACATGCGACCTTGGCCTCAGGGCCACAGAGCGTGAGCAGCACCCTGTCCGCTGTCC
 641 TCGCCACCTTTACCTGGGAGAGAAGTGCCTGTGAGCGGGCCTTGGGACTCACTCCCCATACTCTTTCACCAGGAACGAGC
 721 AGAGTGTTCACTAGTCCTAGTGTGAAGCGGGCACAAGTGACCAAAGCCAATGGTGAGGACCACCTTGGGGGCTGGAGAGC
 801 ACAGCAGGCAGAGCAGGGCTGAGGCGCCATGAGGCCATCACCACCATGCAAGGGAGGAGCAGCCAGCAGCTCTCCTGGGT
 881 GGCCCACTGGCTCCTGCCGGCCAGAGCGCATGAGCACTGACCTTCCTCGTGGGGAAGGTCTGCAGACCCGTGTGAACATG
 961 GCAGAGGCCACACTCCAGCTCCCACCCACATAAACCTTTGCAACCACTTCACTACCTCTCACTGGGTCTCGTGGGCTTGG
1041 GACAGCAACGGTTCTGTTTAGTCAGCTGGTGCAGGTGGTTGGCCCAGCCGATGAGAACTCAAATAGCACGGATTTCCTGG
1121 ATGAGCTACCACGTGGCGCTCTTCAGGTTCTGCCTCTGGGAGGCTGTGTGCACCTCAGTCACCACAGCTCACGGCCGTCC
1201 CCAGTTGAGTCCCCCTTCTGAGGACAAGTTTGAAACTGGGAAGGAGACACCCCCTGGTTCCGCCAGCACCTATCCCACTG
1281 ATAGTGATCCCCTGGCCTCCCCGAGCCTCCTTAGGCAATGGCCACTGGTTTGTAGACAGAGAGTTTCTTGCAGCCTTGAA
1361 AATTTTATTCCCTAAGTGGGGACAGCTCTGGTATTACTGCTTCTTTAATTTGTTCCACAAAAATTATGCTGAAATGGACC
1441 TGAATCAGCCCTGGGTGTGCTTCTGTTGGCGCCTGCTGCTGAGGCCCGGCCTGCCCATCGGCCTGTAGTACGCCATCGAG
1521 GTCATCATGGAGCCAGCCAGCTTCTCTTCTCATCAAGGAGGCAGAGACCCCTGGTGGAAGCCAAGAGTGACCGAAGAGGG
1601 CTTGCATCACGTCACTCCAGTGGTTCCCTCCTTGTCCAAGTCCTCGTTTTAAGGGCATGGCCCGTTGGCTCCAGCCGTTG
1681 GCTTCTGTTCAGGGTCCTTGCTCCCATCAGAGGTGTTTGATTTTGCTCCTGGGGCTGCGATGGAGAACCTTTTGTGGCAG
1761 ATGGTGCTGCCTACATCTCATTGGTTCTCTGTACCTGTGCCCGTTGCGCATGTTCACAGACAGGAGAGTCGCCAGCAATA
1841 CCTTGGCAGCCTTTAAATGTGAAACGTCTGTTACTTGCGCTGGAGGCAGAGGCTGTGCAGGGAGCCTGCTTCTAATCGTG
1921 GGCTCCCTTATCTGTTACGGTTCCCTCCCCTCCTGTTCTAGATGCTGATTCGTTTTCTCACTGGCTGGTTAATTGCTGTC
2001 TACTTAGGCCTCCAAGGCCATAACTGTGCAACATTTTATCTGAGAAGGAAGGAAGGTCAGAAAGTGATCACTGGCACCAC
2081 CACTGTGGCATTCCTGTCACACCAACACAGAAATTCACAGCTCATACTGTTCTCACCTGGGAAACTTGGGAAGGGCTGAT
2161 GAGTTTGGGGCAGATCCTGAATTGCAGCCACACTTGGCCTTCTAGAAGCTGAAGTTGTGCCCTCAAGTGGTCCTAAGTAG
2241 AAGTCCACTTGAGGTATTTGCTGGCACACACCCTCAAGGGTGGTTCAGAAGGTCCTGAAACCTAAGGCAAAAGGCTGCTG
2321 GGGCATGAACAGAACAGACCGTCTCAGGGGCAGCCATGTAAGTGGCAAGCAGGGCTGGTCTCCCTCAAGGTGGTTCTTCA
2401 TTAAGTAAAGATGGCTTCGTGACTAGTGTTTAGCTCCCAGATTTATATTTGGGTTAAAAACTAACTTTTCAATGTGGCAG
2481 TTTCAAAGGATTACTTGATGCAAAGTATGTTTCCTTTCAAAGGGATCTTGACGTGGTACCAGGACTGAGTCATGATTTGG
2561 GCAGAGGCAGTTAACACTGGGAAGCCCTGCCCCTCCCTATGCCCCCTTCACTCCGGGGAACTGAAACCTACTCTGAGTCT
2641 CACATCTCTAAACCTCAGTGCTGAGACCTATGCAGTGGGACTAATCTCATCAAGAATTTTCAGTTGAGGCCGGGCGCAGT
2721 GGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGCGGATCACCTGAGGTCAGGAGTTGGAGACCAGCCTGG
2801 CCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAGAAAGTTAGCCAGGTCTGGTGGTGCGTGCCTGTAATCCCACT
2881 TACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTACAGTGAGCCGAGATCGCGCCACTGCACT
2961 CCACCCTGGGCAACAAGAGCGAAAACTGTCTCAAAAAAAAAAAATTTTTCATTTGAGGTATTCTTCCAGTAGAAGGTTAG
3041 TAAGTTTTTAATGAAACCATTAAAAATTACACTTCCCAGAAAATAGATGACATCAGTGCCCCTTGCTACTTTCTCAGTCC
3121 TCACTATTGCTTTGAGGGCCCAGGTACTGAAACTGGTTGTCTTGAGTTTTGTGTCAGCTTTTTCTCCAGTCCATTATCCC
3201 CCTCCCTTGCTTCTGAAGCAGTCTAGGTTAAACTAGCCAGGCAGGTAGTTGTGGACTGGTGATTTTCAAAAGCCCCACTT
3281 TAGAGATCAGGCCACAGCTTTTTATATCGCACAGGACACATCAGCCTGAGCTGCTGCCTCATGCCTGTTTCCCCAGGAAC
3361 CTCACTCCTTTGGTAGAACCTTGGGATTTTAGAAATTGTGGCTTTTCCATAACTCATTTACTCCAACAGTTGAAGTTACA
3441 CACATTGCTCCCAAATTTGGAAATAGACCACAGTACCTTACCTTTCATTCCCCATCTGGCCTTTACCTTCTTTGCTTCAG
3521 TGGTTGAAAACAGTTGCCATATTCAAAGTATAGTAGATTTCAACCTCACACAAATGACAAGTCCCATTTTACAATCCTAG
3601 GAAGGCCCACCAATTTCATTTCACGCGCCAGGGCGGCTGCAGTTGGAGGCCGAGGGCAGCCCTCTGCTCACTGAATGTCT
3681 TGCATGTGCTGACTGCTGCCCGCAGTGCTGAACATGCCCCACCGCCCAGGCCCAGCACTGCTTGTTGGGTCAGCATCTAG
3761 TGCTGCTGTCACATCTTTGTCTGCACAGCCAGTAGGATTGCCTCAGCCAGGGGGTTTATCAGAAGGTGTGCAAGGCCTTT
3841 GGGGGAACTGAGCCCCTATAGTGGGCAGTCTCCTTTACCTTCCCACCTCCCTGAAAAGCACAGAAGACAGTGCCTTGGTT
3921 TGTGTTTTGAAGCAAACAAGTCAGCTTTCTGGCTTTGCCCCAAAACTGTGATGGAACATAATAAAACTGGAGATATGGTT
4001 TTTAACACTGCAAAAAGGAAAAAGCATCAAGTTTCTACTTCTGGCTGGAAAGCAAAACCAATCTCAGCTGACAAGGCTGG
4081 GCAAACTAAGTTTTCCTGAGCCCATTTTCCTTTGAGCCCTGACCTAGCCTGGCCTTACCTCATTAAGGTTTGGTTAAAGC
4161 AGTGGAAAGGAGGAGGAGGCAGGGGTGGATGGGGGTGTGGGGAGGGGATGAGCACTCTGCAGCCGATTAATCTGTTGGTA
4241 GGGGCCCAGCTTCTTGGGAGTGCTTATTCAGCCCAAGAGTGGAGGCTGTTTACAGCGAGCCCTGGAGATGGCAGCTTGTC
4321 TCCAGCTGGGGAGGGGTCAGGCCCCTAAATTGAAGACCACTTTGGTAGCAGAACTGTAGGGACTGGTGAGTCAACTCACA
4401 GATTCTGCAGCAGCTGCTCCACCCACAATAAAGCAAACGCCGACAGGCTAGACCCCAGATTGCAGGGGCTGCCACCTACA
4481 AGGTGGGACCACAGGCTGCCTCACCGGGATTGTCTGCCACTAAATAGCTGGAGTCACAGATTGAGATAAATGCCACCTTC
4561 AAGGTTGCAGTGAAAAGCATAATCCTATGTGATGAATTTATATGTGTTATTTTTTAAAAAGCTATTTTATTACTGCATGT
4641 TCCCGTCCCGTCTTGTGAATGTGAGTCCCCGCCACCACGTGAGGTGCAGTCGTTGCAGCGGCTGGTGCAGGAGTGCAGCT
4721 GGCGCGTGTGTGATAGCATCTCGTAGGTGTTGCTGCACAAGAGTTAACCAGAGTCAATGCCAAACACATAGTATGAGAAG
4801 TGTACTTTTTAAGAAATTAATTTATTTGAGTTCAAATATTTTTGAAATATAAAAATTGGTTGTATTTTTTAAAGCTATAA
4881 TTCTTGTAGACATTCTGTGGTTAAAAATTTGATTGTGCTTATTAAAAATGGTCATCTATGTTTTGCACTTCAGCTACGTG
4961 AAAATAAAATTTCTTTGGGAAGGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaACCAG----UGUGGUCAGGUGUAa 5'
            |||||    ::|  ||||||| | 
Target 5' agTGGTCCTAAGTAGAAGTCCACTTg 3'
 2226 - 2251 130.00 -16.12
2 
miRNA  3' aaaCCAGUGU--GGUC------AGGUGUAa 5'
             || ||||  ||||       |||||| 
Target 5' agaGGCCACACTCCAGCTCCCACCCACATa 3'
 963 - 992 127.00 -15.30
3 
miRNA  3' aaacCAGUGUGGUCAGGUGUaa 5'
              ||::|:|  ||:||||  
Target 5' gcccGTTGCGCATGTTCACAga 3'
 1799 - 1820 126.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN228611 5 COSMIC
COSN30129780 9 COSMIC
COSN30144127 58 COSMIC
COSN30108686 82 COSMIC
COSN1193778 92 COSMIC
COSN1193780 95 COSMIC
COSN1193782 101 COSMIC
COSN8240739 158 COSMIC
COSN6100104 159 COSMIC
COSN14465065 628 COSMIC
COSN6654268 698 COSMIC
COSN6654269 889 COSMIC
COSN7161336 1111 COSMIC
COSN5800996 1139 COSMIC
COSN29110983 1250 COSMIC
COSN23317725 1404 COSMIC
COSN25385669 1419 COSMIC
COSN9656466 1453 COSMIC
COSN21542540 1500 COSMIC
COSN6654271 2222 COSMIC
COSN29943902 2463 COSMIC
COSN15720591 2626 COSMIC
COSN23710545 2993 COSMIC
COSN5178477 3005 COSMIC
COSN6654272 3069 COSMIC
COSN29921207 3181 COSMIC
COSN21867718 3199 COSMIC
COSN5414689 3281 COSMIC
COSN23762659 3287 COSMIC
COSN15662688 3294 COSMIC
COSN1193784 3464 COSMIC
COSN29425885 3466 COSMIC
COSN24980629 3613 COSMIC
COSN8393546 3788 COSMIC
COSN15661533 3949 COSMIC
COSN6654273 3997 COSMIC
COSN25802881 4121 COSMIC
COSN6654274 4277 COSMIC
COSN22984251 4336 COSMIC
COSN1714817 4930 COSMIC
COSN31552056 4959 COSMIC
rs921986 698 GWAS
rs12949119 3069 GWAS
rs941454 3997 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749793380 3 dbSNP
rs375684610 5 dbSNP
rs759765810 6 dbSNP
rs747655710 8 dbSNP
rs775785764 10 dbSNP
rs760902147 11 dbSNP
rs764256132 13 dbSNP
rs769327578 17 dbSNP
rs1365961246 23 dbSNP
rs1212699103 24 dbSNP
rs772874950 25 dbSNP
rs1457535731 28 dbSNP
rs753768278 29 dbSNP
rs748900303 30 dbSNP
rs372200892 33 dbSNP
rs765046078 34 dbSNP
rs80004939 35 dbSNP
rs1424384803 36 dbSNP
rs772431614 38 dbSNP
rs750256837 39 dbSNP
rs758132153 40 dbSNP
rs1486143157 42 dbSNP
rs779689371 44 dbSNP
rs1331583877 45 dbSNP
rs751211734 46 dbSNP
rs754544300 48 dbSNP
rs780661102 53 dbSNP
rs1347460806 58 dbSNP
rs1375028650 59 dbSNP
rs1304353610 63 dbSNP
rs1236759811 64 dbSNP
rs115576594 66 dbSNP
rs1188832250 69 dbSNP
rs986073495 73 dbSNP
rs1417234535 83 dbSNP
rs910505250 90 dbSNP
rs1403864231 93 dbSNP
rs965318938 96 dbSNP
rs975988458 96 dbSNP
rs923151027 99 dbSNP
rs556270134 100 dbSNP
rs1387837876 106 dbSNP
rs575739685 112 dbSNP
rs1191811396 113 dbSNP
rs1447549495 118 dbSNP
rs957938839 119 dbSNP
rs983340248 124 dbSNP
rs544825549 128 dbSNP
rs749605276 129 dbSNP
rs941816036 130 dbSNP
rs1055270784 138 dbSNP
rs1340261733 141 dbSNP
rs894826643 145 dbSNP
rs1228181620 146 dbSNP
rs1328722169 149 dbSNP
rs1306497469 150 dbSNP
rs1414703665 151 dbSNP
rs1357918488 166 dbSNP
rs913721356 171 dbSNP
rs949011163 177 dbSNP
rs1046685615 184 dbSNP
rs564748607 191 dbSNP
rs1393824331 192 dbSNP
rs902800805 196 dbSNP
rs1292194611 216 dbSNP
rs1374284808 223 dbSNP
rs769146373 223 dbSNP
rs1376313358 228 dbSNP
rs1000183037 230 dbSNP
rs945119580 233 dbSNP
rs1258010254 247 dbSNP
rs1189750565 250 dbSNP
rs1215777300 253 dbSNP
rs1482208938 253 dbSNP
rs1272489103 254 dbSNP
rs1196460601 255 dbSNP
rs1341644032 256 dbSNP
rs1273302255 258 dbSNP
rs1263747609 260 dbSNP
rs1233263450 264 dbSNP
rs537527696 274 dbSNP
rs1046546808 287 dbSNP
rs1306505354 300 dbSNP
rs553809134 301 dbSNP
rs1295537519 304 dbSNP
rs1032534952 307 dbSNP
rs893951581 315 dbSNP
rs62072541 316 dbSNP
rs79257979 319 dbSNP
rs1485991760 340 dbSNP
rs1054798771 341 dbSNP
rs1460883414 344 dbSNP
rs1418423618 346 dbSNP
rs888724097 358 dbSNP
rs1210048840 362 dbSNP
rs1468348512 375 dbSNP
rs534127460 383 dbSNP
rs1037175011 384 dbSNP
rs554403217 386 dbSNP
rs998284402 388 dbSNP
rs1336143668 389 dbSNP
rs1420510368 390 dbSNP
rs1449018603 407 dbSNP
rs1025593820 408 dbSNP
rs1280478226 410 dbSNP
rs950677886 419 dbSNP
rs1030125343 422 dbSNP
rs1377634652 423 dbSNP
rs1323333746 427 dbSNP
rs983757234 428 dbSNP
rs1395131125 433 dbSNP
rs889868458 440 dbSNP
rs1435936037 442 dbSNP
rs1312770280 448 dbSNP
rs184605862 455 dbSNP
rs1032993349 456 dbSNP
rs138054068 468 dbSNP
rs1270209377 469 dbSNP
rs1360926409 483 dbSNP
rs1225711904 486 dbSNP
rs990604551 506 dbSNP
rs916295157 512 dbSNP
rs949107075 514 dbSNP
rs1468920314 516 dbSNP
rs1254946579 517 dbSNP
rs1207440985 522 dbSNP
rs1046135017 528 dbSNP
rs957968260 531 dbSNP
rs549198013 535 dbSNP
rs374954410 548 dbSNP
rs546520770 568 dbSNP
rs1352411918 569 dbSNP
rs754065464 578 dbSNP
rs966905755 579 dbSNP
rs981960817 584 dbSNP
rs927744479 585 dbSNP
rs1344496518 590 dbSNP
rs1318755394 591 dbSNP
rs371142095 592 dbSNP
rs1393509043 601 dbSNP
rs34781023 604 dbSNP
rs751569794 608 dbSNP
rs1454852836 612 dbSNP
rs1397006878 615 dbSNP
rs563031894 617 dbSNP
rs773784251 625 dbSNP
rs1025626306 634 dbSNP
rs759288259 635 dbSNP
rs531381227 643 dbSNP
rs1348127899 644 dbSNP
rs897335900 651 dbSNP
rs551182815 655 dbSNP
rs934186673 667 dbSNP
rs1464658428 668 dbSNP
rs765039597 674 dbSNP
rs1051269537 677 dbSNP
rs571173571 678 dbSNP
rs1190688791 685 dbSNP
rs752608979 695 dbSNP
rs533844473 696 dbSNP
rs1373445643 698 dbSNP
rs921986 698 dbSNP
rs1435598909 701 dbSNP
rs377355882 702 dbSNP
rs923612119 708 dbSNP
rs16961153 718 dbSNP
rs1409393492 721 dbSNP
rs1420301430 727 dbSNP
rs1054041945 737 dbSNP
rs1474494932 738 dbSNP
rs915443775 744 dbSNP
rs942958732 746 dbSNP
rs780922879 749 dbSNP
rs1432502478 750 dbSNP
rs555970217 755 dbSNP
rs1201836535 762 dbSNP
rs1273086141 763 dbSNP
rs1327541315 763 dbSNP
rs576116991 779 dbSNP
rs1353437270 781 dbSNP
rs1292486893 782 dbSNP
rs1415101875 783 dbSNP
rs966652263 784 dbSNP
rs1371212145 787 dbSNP
rs1441746226 797 dbSNP
rs1233308202 801 dbSNP
rs562185464 804 dbSNP
rs1352832614 811 dbSNP
rs982379943 814 dbSNP
rs1034849740 818 dbSNP
rs538414287 827 dbSNP
rs998256264 829 dbSNP
rs1047107441 831 dbSNP
rs529869688 836 dbSNP
rs1248840160 837 dbSNP
rs1005927356 841 dbSNP
rs1206853952 849 dbSNP
rs1480096606 850 dbSNP
rs1016191201 851 dbSNP
rs558401017 865 dbSNP
rs1199942185 870 dbSNP
rs1332597266 871 dbSNP
rs1272411956 875 dbSNP
rs578240324 884 dbSNP
rs921985 889 dbSNP
rs918872954 890 dbSNP
rs1391089255 894 dbSNP
rs1374265376 900 dbSNP
rs1471470040 901 dbSNP
rs1438716261 903 dbSNP
rs554555040 908 dbSNP
rs866696663 909 dbSNP
rs1455210191 911 dbSNP
rs1051731151 923 dbSNP
rs889930358 927 dbSNP
rs573932307 929 dbSNP
rs55854203 930 dbSNP
rs981873660 932 dbSNP
rs1408182598 935 dbSNP
rs748571594 943 dbSNP
rs1179989654 946 dbSNP
rs1466798668 950 dbSNP
rs1251832228 951 dbSNP
rs9909530 959 dbSNP
rs893148827 960 dbSNP
rs1010282495 961 dbSNP
rs1321403719 971 dbSNP
rs1238008986 973 dbSNP
rs956405248 980 dbSNP
rs1232351902 985 dbSNP
rs989584129 987 dbSNP
rs1337282739 988 dbSNP
rs1442883284 991 dbSNP
rs1389080442 1000 dbSNP
rs1383391615 1001 dbSNP
rs1288663884 1002 dbSNP
rs914910753 1003 dbSNP
rs1347306966 1004 dbSNP
rs1278917539 1007 dbSNP
rs1160157425 1009 dbSNP
rs1041723815 1010 dbSNP
rs773150648 1032 dbSNP
rs1348493480 1037 dbSNP
rs1394004948 1042 dbSNP
rs146041779 1051 dbSNP
rs942970938 1052 dbSNP
rs1434870316 1053 dbSNP
rs565684240 1063 dbSNP
rs1204343349 1072 dbSNP
rs1486104019 1074 dbSNP
rs1003436477 1078 dbSNP
rs564739350 1084 dbSNP
rs527529268 1090 dbSNP
rs1035283446 1091 dbSNP
rs959197744 1096 dbSNP
rs532304912 1101 dbSNP
rs1275124613 1103 dbSNP
rs1335807742 1105 dbSNP
rs922788470 1110 dbSNP
rs1011959784 1111 dbSNP
rs1016674348 1129 dbSNP
rs1047137858 1131 dbSNP
rs1342823055 1132 dbSNP
rs962433065 1133 dbSNP
rs1432503187 1134 dbSNP
rs1374432838 1138 dbSNP
rs547280806 1139 dbSNP
rs1467077257 1146 dbSNP
rs1182924073 1147 dbSNP
rs918245917 1149 dbSNP
rs865792659 1163 dbSNP
rs987044433 1165 dbSNP
rs1265121386 1167 dbSNP
rs1185465811 1177 dbSNP
rs1485472219 1184 dbSNP
rs771032023 1185 dbSNP
rs1471857460 1186 dbSNP
rs942809820 1193 dbSNP
rs552475472 1194 dbSNP
rs1012181497 1197 dbSNP
rs1417934496 1198 dbSNP
rs567585208 1198 dbSNP
rs1291855771 1200 dbSNP
rs1414476414 1202 dbSNP
rs1054626906 1206 dbSNP
rs906366292 1213 dbSNP
rs1334467417 1221 dbSNP
rs1003343633 1233 dbSNP
rs1393741691 1249 dbSNP
rs1298296067 1251 dbSNP
rs1161059350 1262 dbSNP
rs1398133150 1263 dbSNP
rs1425609459 1265 dbSNP
rs914685235 1269 dbSNP
rs1410344038 1273 dbSNP
rs1474792722 1277 dbSNP
rs1257964373 1279 dbSNP
rs1307112267 1283 dbSNP
rs1348633763 1286 dbSNP
rs1436270552 1293 dbSNP
rs1249938311 1297 dbSNP
rs1196414650 1303 dbSNP
rs946103210 1304 dbSNP
rs1295258522 1307 dbSNP
rs1341109166 1310 dbSNP
rs1271758816 1316 dbSNP
rs529636183 1319 dbSNP
rs1042126839 1320 dbSNP
rs1233193028 1322 dbSNP
rs907180762 1326 dbSNP
rs1282668233 1338 dbSNP
rs1333569472 1338 dbSNP
rs776785626 1341 dbSNP
rs1196748337 1342 dbSNP
rs549771035 1343 dbSNP
rs1482393925 1344 dbSNP
rs1323888999 1349 dbSNP
rs1460831343 1368 dbSNP
rs895049496 1373 dbSNP
rs56001517 1375 dbSNP
rs1468827531 1381 dbSNP
rs963652493 1382 dbSNP
rs1422756959 1389 dbSNP
rs1184715353 1394 dbSNP
rs531225261 1402 dbSNP
rs1179352747 1403 dbSNP
rs538749401 1409 dbSNP
rs1251210911 1413 dbSNP
rs547832873 1416 dbSNP
rs188582444 1417 dbSNP
rs563761680 1419 dbSNP
rs558339267 1426 dbSNP
rs1167797383 1428 dbSNP
rs374187171 1435 dbSNP
rs1348118461 1438 dbSNP
rs1025750354 1443 dbSNP
rs955028395 1445 dbSNP
rs762789969 1447 dbSNP
rs1378530139 1448 dbSNP
rs34761022 1453 dbSNP
rs1313441697 1454 dbSNP
rs908690034 1455 dbSNP
rs750287364 1456 dbSNP
rs1325286165 1461 dbSNP
rs941469109 1463 dbSNP
rs1383955895 1465 dbSNP
rs911511027 1471 dbSNP
rs368164919 1472 dbSNP
rs1332197733 1476 dbSNP
rs1393397730 1480 dbSNP
rs1193031530 1482 dbSNP
rs1478658743 1488 dbSNP
rs534425467 1489 dbSNP
rs894483086 1493 dbSNP
rs990346454 1500 dbSNP
rs181378372 1501 dbSNP
rs1285356899 1506 dbSNP
rs1340436312 1508 dbSNP
rs574294653 1509 dbSNP
rs1355348878 1512 dbSNP
rs906482310 1513 dbSNP
rs1041768283 1514 dbSNP
rs1232838912 1518 dbSNP
rs928637243 1519 dbSNP
rs938732326 1520 dbSNP
rs1428545604 1523 dbSNP
rs1325679054 1529 dbSNP
rs1281693662 1542 dbSNP
rs1421773590 1547 dbSNP
rs1483175334 1549 dbSNP
rs1003457180 1557 dbSNP
rs1373820405 1557 dbSNP
rs1263204932 1563 dbSNP
rs1427351963 1564 dbSNP
rs1031276548 1567 dbSNP
rs1056198290 1572 dbSNP
rs895089178 1573 dbSNP
rs1196249949 1583 dbSNP
rs1489070678 1586 dbSNP
rs892286786 1587 dbSNP
rs184428832 1593 dbSNP
rs1038177749 1594 dbSNP
rs1022021913 1599 dbSNP
rs1212784796 1601 dbSNP
rs556529441 1601 dbSNP
rs576411117 1612 dbSNP
rs1455441869 1628 dbSNP
rs1338608949 1638 dbSNP
rs963686666 1646 dbSNP
rs34140807 1647 dbSNP
rs545095408 1647 dbSNP
rs1401542239 1655 dbSNP
rs1353809440 1656 dbSNP
rs751454043 1664 dbSNP
rs1029278689 1665 dbSNP
rs1361021361 1666 dbSNP
rs1168361798 1670 dbSNP
rs1409927706 1671 dbSNP
rs1387200144 1672 dbSNP
rs1025357364 1677 dbSNP
rs1320178401 1678 dbSNP
rs1474463863 1694 dbSNP
rs1363229472 1695 dbSNP
rs1443580664 1701 dbSNP
rs1302410763 1704 dbSNP
rs1180965157 1716 dbSNP
rs983039784 1723 dbSNP
rs1238722441 1727 dbSNP
rs908714804 1733 dbSNP
rs114718667 1738 dbSNP
rs1258564562 1739 dbSNP
rs1007919411 1740 dbSNP
rs974563969 1741 dbSNP
rs1229127527 1742 dbSNP
rs567821812 1749 dbSNP
rs948775178 1750 dbSNP
rs1334027527 1755 dbSNP
rs1460308329 1761 dbSNP
rs1417658003 1762 dbSNP
rs964303352 1767 dbSNP
rs1045799648 1769 dbSNP
rs928602372 1777 dbSNP
rs371956630 1780 dbSNP
rs990377541 1782 dbSNP
rs1415422436 1791 dbSNP
rs1262019920 1794 dbSNP
rs1329284729 1795 dbSNP
rs1207503025 1800 dbSNP
rs1021807582 1802 dbSNP
rs527467967 1803 dbSNP
rs1200508383 1804 dbSNP
rs1052334451 1808 dbSNP
rs1245834762 1809 dbSNP
rs892312216 1816 dbSNP
rs540856505 1820 dbSNP
rs1323746950 1823 dbSNP
rs1305204540 1827 dbSNP
rs1239687956 1829 dbSNP
rs560998544 1834 dbSNP
rs977987280 1837 dbSNP
rs1194099115 1850 dbSNP
rs758241468 1861 dbSNP
rs1043876804 1866 dbSNP
rs928776640 1867 dbSNP
rs899628665 1874 dbSNP
rs938745754 1875 dbSNP
rs991533029 1879 dbSNP
rs139810193 1880 dbSNP
rs1457854994 1884 dbSNP
rs1158444232 1886 dbSNP
rs750074362 1887 dbSNP
rs1287559818 1893 dbSNP
rs1380405211 1896 dbSNP
rs1386731539 1899 dbSNP
rs947989114 1900 dbSNP
rs1004887704 1918 dbSNP
rs1191693548 1919 dbSNP
rs1015804880 1923 dbSNP
rs1367307436 1924 dbSNP
rs530019279 1930 dbSNP
rs755871101 1932 dbSNP
rs779414290 1935 dbSNP
rs533680094 1938 dbSNP
rs375020980 1939 dbSNP
rs1331043733 1941 dbSNP
rs890908092 1950 dbSNP
rs981512268 1955 dbSNP
rs1008364929 1957 dbSNP
rs554067255 1960 dbSNP
rs1418749327 1961 dbSNP
rs1017972706 1962 dbSNP
rs1360699350 1965 dbSNP
rs571052664 1973 dbSNP
rs1011846312 2003 dbSNP
rs1052785262 2010 dbSNP
rs74979460 2015 dbSNP
rs1264676569 2021 dbSNP
rs1487398229 2026 dbSNP
rs1259426125 2028 dbSNP
rs946620212 2033 dbSNP
rs189354035 2034 dbSNP
rs1265533008 2043 dbSNP
rs748535385 2044 dbSNP
rs1344483796 2045 dbSNP
rs1472184625 2054 dbSNP
rs899659625 2055 dbSNP
rs996564121 2060 dbSNP
rs977643311 2064 dbSNP
rs747494379 2081 dbSNP
rs960162608 2101 dbSNP
rs991956091 2102 dbSNP
rs1299730243 2109 dbSNP
rs1393901394 2111 dbSNP
rs915914400 2133 dbSNP
rs1400927902 2135 dbSNP
rs1302867289 2137 dbSNP
rs1349470490 2142 dbSNP
rs1456729409 2146 dbSNP
rs890792648 2148 dbSNP
rs1371202240 2156 dbSNP
rs1169708599 2158 dbSNP
rs1478056821 2164 dbSNP
rs1425496609 2170 dbSNP
rs1300197086 2174 dbSNP
rs942001488 2176 dbSNP
rs973367648 2177 dbSNP
rs919881601 2186 dbSNP
rs963031741 2188 dbSNP
rs929871243 2191 dbSNP
rs149666800 2193 dbSNP
rs912361046 2195 dbSNP
rs970186333 2203 dbSNP
rs1285964768 2209 dbSNP
rs4925172 2222 dbSNP
rs1291794124 2224 dbSNP
rs1242185393 2234 dbSNP
rs1339469881 2239 dbSNP
rs928664426 2244 dbSNP
rs534397999 2247 dbSNP
rs1397204005 2261 dbSNP
rs1397480149 2264 dbSNP
rs1330668148 2269 dbSNP
rs144472422 2270 dbSNP
rs1319491870 2272 dbSNP
rs899577291 2281 dbSNP
rs1161204700 2288 dbSNP
rs1472596483 2289 dbSNP
rs1369215913 2307 dbSNP
rs746089422 2313 dbSNP
rs1042728277 2316 dbSNP
rs988864210 2317 dbSNP
rs1199880015 2319 dbSNP
rs770063085 2323 dbSNP
rs1206364186 2325 dbSNP
rs1271695351 2327 dbSNP
rs775591276 2328 dbSNP
rs999482696 2332 dbSNP
rs1284480430 2342 dbSNP
rs1246523255 2347 dbSNP
rs946680475 2351 dbSNP
rs1307868534 2354 dbSNP
rs1447467611 2359 dbSNP
rs1482717464 2361 dbSNP
rs1035879491 2373 dbSNP
rs960442848 2374 dbSNP
rs1321361634 2376 dbSNP
rs1202901792 2385 dbSNP
rs1259478624 2387 dbSNP
rs1165261749 2388 dbSNP
rs979288323 2389 dbSNP
rs1012962470 2402 dbSNP
rs1182467077 2416 dbSNP
rs762740527 2420 dbSNP
rs1050807292 2434 dbSNP
rs1211315758 2441 dbSNP
rs1284696523 2445 dbSNP
rs1173063616 2447 dbSNP
rs1378460605 2448 dbSNP
rs1391144018 2450 dbSNP
rs180907178 2455 dbSNP
rs1331519494 2465 dbSNP
rs973398613 2475 dbSNP
rs1325226728 2481 dbSNP
rs1306749042 2485 dbSNP
rs1398417412 2490 dbSNP
rs919232309 2519 dbSNP
rs148434050 2523 dbSNP
rs898140461 2524 dbSNP
rs1421660486 2532 dbSNP
rs983066681 2532 dbSNP
rs995786767 2533 dbSNP
rs912405864 2534 dbSNP
rs1023200518 2542 dbSNP
rs943905732 2547 dbSNP
rs1262100473 2549 dbSNP
rs1216885619 2552 dbSNP
rs1298116439 2558 dbSNP
rs1275869321 2560 dbSNP
rs1218601165 2567 dbSNP
rs1039556718 2568 dbSNP
rs1003008328 2569 dbSNP
rs576477986 2579 dbSNP
rs1423258084 2581 dbSNP
rs1035855134 2585 dbSNP
rs115080682 2586 dbSNP
rs867268897 2588 dbSNP
rs1216506197 2596 dbSNP
rs1339580943 2600 dbSNP
rs989285242 2602 dbSNP
rs1225839632 2603 dbSNP
rs1282406960 2607 dbSNP
rs142910274 2615 dbSNP
rs969098795 2616 dbSNP
rs1333532377 2629 dbSNP
rs1236965288 2640 dbSNP
rs1482426312 2669 dbSNP
rs1042756267 2671 dbSNP
rs4925173 2674 dbSNP
rs999117245 2689 dbSNP
rs1477737540 2691 dbSNP
rs555694549 2691 dbSNP
rs896060997 2692 dbSNP
rs1424753816 2701 dbSNP
rs932559853 2710 dbSNP
rs1248833378 2713 dbSNP
rs1013077022 2714 dbSNP
rs1235278383 2716 dbSNP
rs187008379 2717 dbSNP
rs912365835 2721 dbSNP
rs1167037717 2727 dbSNP
rs572563952 2728 dbSNP
rs189384537 2729 dbSNP
rs1415540211 2735 dbSNP
rs1216713608 2737 dbSNP
rs939814846 2747 dbSNP
rs572230364 2748 dbSNP
rs994859015 2754 dbSNP
rs1026317271 2755 dbSNP
rs950742767 2756 dbSNP
rs1377197107 2757 dbSNP
rs1283690660 2765 dbSNP
rs540835615 2766 dbSNP
rs1360962579 2771 dbSNP
rs1329959672 2781 dbSNP
rs914875597 2788 dbSNP
rs912511422 2791 dbSNP
rs1465547500 2795 dbSNP
rs1412194311 2797 dbSNP
rs1363937516 2805 dbSNP
rs965272351 2817 dbSNP
rs567346062 2818 dbSNP
rs930926983 2819 dbSNP
rs867731146 2829 dbSNP
rs947137588 2841 dbSNP
rs1472876860 2849 dbSNP
rs1244413395 2850 dbSNP
rs1196725612 2852 dbSNP
rs1457225306 2855 dbSNP
rs1257538233 2860 dbSNP
rs978465557 2864 dbSNP
rs561147865 2865 dbSNP
rs766069322 2877 dbSNP
rs1210611048 2878 dbSNP
rs1229073664 2882 dbSNP
rs1248891336 2886 dbSNP
rs1464558483 2887 dbSNP
rs1381499654 2893 dbSNP
rs772176004 2898 dbSNP
rs111817220 2899 dbSNP
rs1248804767 2902 dbSNP
rs1378215844 2906 dbSNP
rs1010336991 2913 dbSNP
rs1056797781 2930 dbSNP
rs896078681 2935 dbSNP
rs1349656384 2936 dbSNP
rs1163680211 2937 dbSNP
rs1478667418 2939 dbSNP
rs1191157944 2942 dbSNP
rs1386580363 2943 dbSNP
rs948958751 2948 dbSNP
rs574339835 2949 dbSNP
rs1423626060 2950 dbSNP
rs758741675 2951 dbSNP
rs1487406466 2971 dbSNP
rs1245892269 2978 dbSNP
rs778048323 2981 dbSNP
rs1361813845 2982 dbSNP
rs1283983788 2988 dbSNP
rs1309865887 2993 dbSNP
rs1385560298 2993 dbSNP
rs560071064 2993 dbSNP
rs77755205 2993 dbSNP
rs1387544545 3001 dbSNP
rs563478530 3002 dbSNP
rs181439081 3004 dbSNP
rs556137547 3005 dbSNP
rs544945450 3006 dbSNP
rs1418637044 3007 dbSNP
rs1435440630 3009 dbSNP
rs747519924 3019 dbSNP
rs757831578 3028 dbSNP
rs375472343 3030 dbSNP
rs1230307189 3031 dbSNP
rs972513545 3034 dbSNP
rs919635743 3035 dbSNP
rs931042496 3049 dbSNP
rs1207031434 3058 dbSNP
rs1225668424 3059 dbSNP
rs1302416381 3059 dbSNP
rs1338899165 3067 dbSNP
rs12949119 3069 dbSNP
rs1452574411 3071 dbSNP
rs1385080728 3078 dbSNP
rs1221222459 3103 dbSNP
rs547627386 3121 dbSNP
rs1464490874 3127 dbSNP
rs938945507 3130 dbSNP
rs1057497990 3135 dbSNP
rs567844432 3137 dbSNP
rs1182349792 3139 dbSNP
rs1421163366 3140 dbSNP
rs1193272746 3142 dbSNP
rs1478240969 3147 dbSNP
rs1410557812 3149 dbSNP
rs891963366 3155 dbSNP
rs1471430511 3158 dbSNP
rs1028161186 3164 dbSNP
rs1257167344 3173 dbSNP
rs767516886 3179 dbSNP
rs1340702385 3183 dbSNP
rs142575235 3187 dbSNP
rs978607502 3188 dbSNP
rs924395556 3193 dbSNP
rs1277909665 3194 dbSNP
rs1217675870 3198 dbSNP
rs1326589147 3201 dbSNP
rs1043220404 3203 dbSNP
rs1404560655 3215 dbSNP
rs1400863720 3234 dbSNP
rs934407977 3249 dbSNP
rs1337353626 3262 dbSNP
rs904652889 3278 dbSNP
rs1397870808 3280 dbSNP
rs1449885256 3281 dbSNP
rs1372402964 3293 dbSNP
rs992931175 3294 dbSNP
rs144918345 3307 dbSNP
rs760872533 3309 dbSNP
rs1256928956 3310 dbSNP
rs1289117727 3311 dbSNP
rs1456793963 3321 dbSNP
rs1349986453 3323 dbSNP
rs1226600995 3325 dbSNP
rs954681138 3335 dbSNP
rs948976706 3345 dbSNP
rs562801712 3346 dbSNP
rs780280330 3349 dbSNP
rs1315073548 3366 dbSNP
rs749492233 3377 dbSNP
rs768472878 3393 dbSNP
rs1374481373 3398 dbSNP
rs1330439315 3402 dbSNP
rs919770107 3405 dbSNP
rs930855657 3410 dbSNP
rs952466935 3422 dbSNP
rs1161731030 3427 dbSNP
rs979836826 3428 dbSNP
rs147969771 3440 dbSNP
rs938287256 3442 dbSNP
rs1206460816 3451 dbSNP
rs1251672494 3456 dbSNP
rs538620213 3465 dbSNP
rs1179812732 3466 dbSNP
rs1481798156 3468 dbSNP
rs1188947316 3469 dbSNP
rs1265675902 3475 dbSNP
rs1207719518 3477 dbSNP
rs913506063 3478 dbSNP
rs543363077 3481 dbSNP
rs886553112 3489 dbSNP
rs1008956768 3493 dbSNP
rs1472257820 3496 dbSNP
rs1161305015 3503 dbSNP
rs1350842396 3507 dbSNP
rs558544599 3508 dbSNP
rs750149290 3521 dbSNP
rs1019380153 3524 dbSNP
rs1391758754 3525 dbSNP
rs1308529372 3527 dbSNP
rs1442811059 3528 dbSNP
rs1337335994 3530 dbSNP
rs946315156 3545 dbSNP
rs1386430081 3549 dbSNP
rs1043640358 3565 dbSNP
rs900463428 3571 dbSNP
rs996772568 3594 dbSNP
rs1418016733 3598 dbSNP
rs1028275729 3601 dbSNP
rs1379738487 3610 dbSNP
rs572168964 3614 dbSNP
rs1471412873 3624 dbSNP
rs1307366666 3626 dbSNP
rs531166522 3627 dbSNP
rs1376311660 3628 dbSNP
rs1198514600 3632 dbSNP
rs77272379 3634 dbSNP
rs1269228668 3635 dbSNP
rs538603929 3635 dbSNP
rs1284627562 3636 dbSNP
rs1487051093 3636 dbSNP
rs1224301283 3637 dbSNP
rs1389749572 3643 dbSNP
rs574569156 3644 dbSNP
rs1272876430 3646 dbSNP
rs890460442 3650 dbSNP
rs543290341 3652 dbSNP
rs1014919453 3653 dbSNP
rs1360003114 3654 dbSNP
rs1319016092 3684 dbSNP
rs961630683 3687 dbSNP
rs994082722 3687 dbSNP
rs992551865 3691 dbSNP
rs774050573 3702 dbSNP
rs547772419 3703 dbSNP
rs1201163344 3715 dbSNP
rs577223811 3716 dbSNP
rs150405278 3724 dbSNP
rs920871016 3725 dbSNP
rs930898931 3728 dbSNP
rs1274566498 3742 dbSNP
rs1199778361 3750 dbSNP
rs1324067912 3754 dbSNP
rs1340572847 3761 dbSNP
rs1034064843 3771 dbSNP
rs959767393 3780 dbSNP
rs1048376921 3782 dbSNP
rs1317836834 3783 dbSNP
rs1433050103 3788 dbSNP
rs1357495050 3795 dbSNP
rs761838507 3799 dbSNP
rs559391396 3804 dbSNP
rs908014377 3806 dbSNP
rs1408800078 3808 dbSNP
rs944787750 3811 dbSNP
rs1040424730 3812 dbSNP
rs946319413 3814 dbSNP
rs1418427344 3815 dbSNP
rs1441537583 3821 dbSNP
rs867507432 3824 dbSNP
rs979008171 3829 dbSNP
rs926141226 3831 dbSNP
rs932111642 3836 dbSNP
rs1461677885 3840 dbSNP
rs1050479349 3842 dbSNP
rs1042323423 3844 dbSNP
rs1249459593 3849 dbSNP
rs1274061097 3850 dbSNP
rs1216516766 3854 dbSNP
rs1377132580 3858 dbSNP
rs1283633905 3865 dbSNP
rs1453990871 3871 dbSNP
rs890573915 3875 dbSNP
rs900577915 3876 dbSNP
rs944807471 3880 dbSNP
rs1355449484 3899 dbSNP
rs1167657243 3909 dbSNP
rs1170773820 3909 dbSNP
rs776271769 3918 dbSNP
rs1411252424 3920 dbSNP
rs996216545 3921 dbSNP
rs1036797075 3923 dbSNP
rs1445177524 3934 dbSNP
rs1388320981 3941 dbSNP
rs1467513527 3950 dbSNP
rs528116827 3954 dbSNP
rs1480209388 3958 dbSNP
rs548265178 3958 dbSNP
rs1402964898 3961 dbSNP
rs1233221604 3966 dbSNP
rs1206916711 3967 dbSNP
rs1395489642 3970 dbSNP
rs904467721 3971 dbSNP
rs772192830 3973 dbSNP
rs773294023 3977 dbSNP
rs1361679629 3982 dbSNP
rs1307771096 3984 dbSNP
rs1000087819 3993 dbSNP
rs941454 3997 dbSNP
rs1443924743 3998 dbSNP
rs955866160 4005 dbSNP
rs753507985 4026 dbSNP
rs1024048530 4029 dbSNP
rs1297310806 4031 dbSNP
rs969763347 4032 dbSNP
rs1386524617 4035 dbSNP
rs979769304 4038 dbSNP
rs920233806 4054 dbSNP
rs952417859 4066 dbSNP
rs561392109 4067 dbSNP
rs1001401806 4073 dbSNP
rs1178666078 4077 dbSNP
rs1487376701 4087 dbSNP
rs1268536571 4095 dbSNP
rs1343712881 4103 dbSNP
rs185977734 4107 dbSNP
rs960081292 4114 dbSNP
rs1283917789 4119 dbSNP
rs371881857 4124 dbSNP
rs1239001369 4127 dbSNP
rs944924868 4133 dbSNP
rs1269633430 4134 dbSNP
rs992576579 4137 dbSNP
rs1309615573 4154 dbSNP
rs1040559092 4157 dbSNP
rs1345265090 4162 dbSNP
rs1465066648 4164 dbSNP
rs1366921728 4168 dbSNP
rs866582920 4168 dbSNP
rs751931344 4178 dbSNP
rs1434880817 4194 dbSNP
rs569986582 4195 dbSNP
rs1345777538 4200 dbSNP
rs1161197199 4201 dbSNP
rs1431271259 4206 dbSNP
rs1428313727 4208 dbSNP
rs1199535633 4225 dbSNP
rs926174859 4226 dbSNP
rs538948284 4230 dbSNP
rs932229312 4241 dbSNP
rs1263083988 4249 dbSNP
rs1208599336 4251 dbSNP
rs1323334589 4253 dbSNP
rs1264090718 4255 dbSNP
rs1223781040 4257 dbSNP
rs72561727 4263 dbSNP
rs1043759288 4266 dbSNP
rs1292981569 4275 dbSNP
rs986302225 4276 dbSNP
rs12939757 4277 dbSNP
rs72550754 4280 dbSNP
rs1053077043 4282 dbSNP
rs1174277774 4285 dbSNP
rs555023042 4286 dbSNP
rs1036421788 4287 dbSNP
rs891704350 4289 dbSNP
rs1176809428 4293 dbSNP
rs1471083900 4295 dbSNP
rs1421826698 4296 dbSNP
rs1014112754 4297 dbSNP
rs1429235432 4304 dbSNP
rs138194958 4305 dbSNP
rs570923160 4309 dbSNP
rs1461228883 4324 dbSNP
rs1320361385 4330 dbSNP
rs80223940 4334 dbSNP
rs1316444330 4337 dbSNP
rs1388847072 4339 dbSNP
rs1001217752 4341 dbSNP
rs1307597686 4348 dbSNP
rs888401939 4360 dbSNP
rs1450367588 4366 dbSNP
rs781615020 4368 dbSNP
rs755797170 4370 dbSNP
rs1454434670 4372 dbSNP
rs1394026034 4373 dbSNP
rs1167605792 4376 dbSNP
rs1001432904 4382 dbSNP
rs1162689836 4395 dbSNP
rs770215821 4397 dbSNP
rs1244367252 4406 dbSNP
rs1185933171 4413 dbSNP
rs1329494889 4422 dbSNP
rs1034210717 4424 dbSNP
rs1207680136 4434 dbSNP
rs750957775 4436 dbSNP
rs540045812 4439 dbSNP
rs1015213935 4440 dbSNP
rs966675606 4442 dbSNP
rs557198104 4443 dbSNP
rs922066360 4445 dbSNP
rs1248048164 4448 dbSNP
rs932071137 4454 dbSNP
rs1266589777 4456 dbSNP
rs1431362642 4461 dbSNP
rs1327892408 4466 dbSNP
rs1392185450 4467 dbSNP
rs979478570 4469 dbSNP
rs190045270 4481 dbSNP
rs1414246262 4487 dbSNP
rs1424142556 4490 dbSNP
rs935386394 4505 dbSNP
rs1473063279 4507 dbSNP
rs1469021438 4509 dbSNP
rs1363592701 4511 dbSNP
rs576523237 4516 dbSNP
rs1052847791 4517 dbSNP
rs577169965 4518 dbSNP
rs1158744936 4520 dbSNP
rs1343605312 4521 dbSNP
rs780042702 4525 dbSNP
rs999853179 4526 dbSNP
rs1459774090 4529 dbSNP
rs546111442 4531 dbSNP
rs1032638400 4533 dbSNP
rs1224669532 4546 dbSNP
rs949943835 4550 dbSNP
rs149158913 4572 dbSNP
rs1348370371 4580 dbSNP
rs749490134 4584 dbSNP
rs1278753841 4588 dbSNP
rs1045562287 4589 dbSNP
rs1337278924 4601 dbSNP
rs879495569 4603 dbSNP
rs912061110 4607 dbSNP
rs966217101 4610 dbSNP
rs1304964432 4616 dbSNP
rs1227196923 4617 dbSNP
rs572776361 4635 dbSNP
rs1304436738 4644 dbSNP
rs145072256 4646 dbSNP
rs919381983 4647 dbSNP
rs1471382386 4650 dbSNP
rs1001245448 4651 dbSNP
rs930717290 4653 dbSNP
rs1196861888 4655 dbSNP
rs561787879 4656 dbSNP
rs1479882234 4660 dbSNP
rs879918903 4661 dbSNP
rs1268981326 4667 dbSNP
rs1049113926 4671 dbSNP
rs1207172572 4672 dbSNP
rs926595340 4675 dbSNP
rs183194259 4680 dbSNP
rs1483436046 4681 dbSNP
rs1352602691 4684 dbSNP
rs1055695407 4686 dbSNP
rs887519454 4693 dbSNP
rs1004573716 4696 dbSNP
rs1223141123 4697 dbSNP
rs1014990343 4699 dbSNP
rs895641056 4700 dbSNP
rs1428796456 4706 dbSNP
rs894996341 4707 dbSNP
rs1325895042 4716 dbSNP
rs1014055248 4719 dbSNP
rs1041934560 4722 dbSNP
rs550161399 4724 dbSNP
rs1429627288 4725 dbSNP
rs976308325 4726 dbSNP
rs563548142 4727 dbSNP
rs138013979 4731 dbSNP
rs1165992003 4732 dbSNP
rs1466148167 4737 dbSNP
rs1241052084 4738 dbSNP
rs1202860928 4739 dbSNP
rs1368226955 4740 dbSNP
rs1265281338 4741 dbSNP
rs953560708 4743 dbSNP
rs747892807 4744 dbSNP
rs1270806899 4748 dbSNP
rs1007785671 4749 dbSNP
rs925415316 4750 dbSNP
rs1371653102 4758 dbSNP
rs1019157137 4760 dbSNP
rs866702796 4761 dbSNP
rs544102417 4777 dbSNP
rs771994574 4778 dbSNP
rs972295281 4780 dbSNP
rs1177819484 4783 dbSNP
rs935401772 4789 dbSNP
rs1407816257 4790 dbSNP
rs1408690039 4795 dbSNP
rs988173974 4804 dbSNP
rs1167930325 4805 dbSNP
rs1450775294 4815 dbSNP
rs1295938121 4817 dbSNP
rs1383375656 4818 dbSNP
rs1182884943 4819 dbSNP
rs571318977 4820 dbSNP
rs1238941748 4821 dbSNP
rs1396225850 4831 dbSNP
rs570374419 4836 dbSNP
rs1273822230 4849 dbSNP
rs1311789357 4851 dbSNP
rs1382771128 4863 dbSNP
rs552446272 4878 dbSNP
rs1357365151 4887 dbSNP
rs566057729 4893 dbSNP
rs1247287705 4903 dbSNP
rs1357046800 4909 dbSNP
rs1385475985 4909 dbSNP
rs952134615 4913 dbSNP
rs1439583828 4916 dbSNP
rs984842910 4922 dbSNP
rs1329109939 4934 dbSNP
rs1431142473 4940 dbSNP
rs1275279142 4941 dbSNP
rs1162879364 4947 dbSNP
rs1341365688 4948 dbSNP
rs1417246181 4954 dbSNP
rs926627914 4958 dbSNP
rs1231229173 4959 dbSNP
rs937954158 4966 dbSNP
rs1484384056 4976 dbSNP
rs1056125793 4982 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 140775.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaaccAGUG-UGGUCAGGUGuaa 5'
               |::| |||| |:|||   
Target 5' aaccuUUGCAACCACUUCACuac 3'
 		4 - 26
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaaccAGUG-UGGUCAGGUGuaa 5'
               |::| |||| |:|||   
Target 5' aaccuUUGCAACCACUUCACuac 3'
 		3 - 25
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177608. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_10 PAR-CLIP data was present in ERX177620. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_10 PAR-CLIP data was present in ERX177622. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_12 PAR-CLIP data was present in ERX177632. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_10 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760591. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_B ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000406438.3 | 3UTR | AUAAACCUUUGCAACCACUUCACUACCUCUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000406438.3 | 3UTR | UAAACCUUUGCAACCACUUCACUACCUCUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4491 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056779 ARID5B AT-rich interaction domain 5B 2 2
MIRT061577 BTG2 BTG anti-proliferation factor 2 2 2
MIRT063828 SRP9 signal recognition particle 9 2 4
MIRT102306 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT186634 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT191243 STYX serine/threonine/tyrosine interacting protein 2 2
MIRT195908 SRSF11 serine and arginine rich splicing factor 11 2 4
MIRT240343 UBXN2B UBX domain protein 2B 2 2
MIRT271178 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT286219 TMEM97 transmembrane protein 97 2 4
MIRT314182 OCLN occludin 2 4
MIRT323938 AKAP2 A-kinase anchoring protein 2 2 4
MIRT323940 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 4
MIRT340113 TXLNA taxilin alpha 2 2
MIRT450333 LRWD1 leucine rich repeats and WD repeat domain containing 1 2 2
MIRT451283 ZNF101 zinc finger protein 101 2 2
MIRT451879 SOD2 superoxide dismutase 2 2 8
MIRT453577 CRCP CGRP receptor component 2 2
MIRT454366 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT454797 STOML3 stomatin like 3 2 2
MIRT459801 POTED POTE ankyrin domain family member D 2 10
MIRT460911 POLQ DNA polymerase theta 2 2
MIRT468082 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT470281 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 2
MIRT471876 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT476147 GPR137C G protein-coupled receptor 137C 2 8
MIRT478056 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 10
MIRT501054 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 4
MIRT501732 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT502214 HSPB8 heat shock protein family B (small) member 8 2 2
MIRT505243 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT505957 RAN RAN, member RAS oncogene family 2 6
MIRT507996 BCL2L13 BCL2 like 13 2 4
MIRT510433 ZNF207 zinc finger protein 207 2 6
MIRT510827 SBNO1 strawberry notch homolog 1 2 4
MIRT511493 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 4
MIRT512129 CREBL2 cAMP responsive element binding protein like 2 2 8
MIRT514512 SHISA9 shisa family member 9 2 4
MIRT516482 RAB32 RAB32, member RAS oncogene family 2 4
MIRT519514 RBM22 RNA binding motif protein 22 2 4
MIRT523367 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT524217 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT524649 C4orf32 family with sequence similarity 241 member A 2 2
MIRT528297 ZNF76 zinc finger protein 76 2 2
MIRT528577 ITGB3BP integrin subunit beta 3 binding protein 2 2
MIRT530458 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT535774 MYCN MYCN proto-oncogene, bHLH transcription factor 2 2
MIRT544239 CCBL2 kynurenine aminotransferase 3 2 2
MIRT546733 RNF217 ring finger protein 217 2 2
MIRT550360 INCENP inner centromere protein 2 4
MIRT553343 TRPC3 transient receptor potential cation channel subfamily C member 3 2 4
MIRT556629 LAPTM4A lysosomal protein transmembrane 4 alpha 2 2
MIRT558006 FAM122B family with sequence similarity 122B 2 2
MIRT558994 CA8 carbonic anhydrase 8 2 2
MIRT560418 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565717 SESN3 sestrin 3 2 2
MIRT566271 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 2
MIRT568161 CCDC6 coiled-coil domain containing 6 2 2
MIRT569753 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT573959 FIGNL1 fidgetin like 1 2 2
MIRT574530 PEG10 paternally expressed 10 2 2
MIRT609453 CCDC149 coiled-coil domain containing 149 2 2
MIRT614047 THBS2 thrombospondin 2 2 2
MIRT628418 ATMIN ATM interactor 2 2
MIRT689556 XPO6 exportin 6 2 2
MIRT725598 CDH7 cadherin 7 2 2
MIRT735561 TRIM7 tripartite motif containing 7 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated

Error report submission