pre-miRNA Information
pre-miRNA hsa-mir-4433a   
Genomic Coordinates chr2: 64340759 - 64340839
Description Homo sapiens miR-4433a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4433a-3p
Sequence 51| ACAGGAGUGGGGGUGGGACAU |71
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs751480515 9 dbSNP
rs557760377 15 dbSNP
rs1479580865 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMAD7   
Synonyms CRCS3, MADH7, MADH8
Description SMAD family member 7
Transcript NM_005904   
Expression
Putative miRNA Targets on SMAD7
3'UTR of SMAD7
(miRNA target sites are highlighted)
>SMAD7|NM_005904|3'UTR
   1 CCGCGTGCGGAGGGGACAGAGCGTGAGCTGAGCAGGCCACACTTCAAACTACTTTGCTGCTAATATTTTCCTCCTGAGTG
  81 CTTGCTTTTCATGCAAACTCTTTGGTCGTTTTTTTTTTGTTTGTTGGTTGGTTTTCTTCTTCTCGTCCTCGTTTGTGTTC
 161 TGTTTTGTTTCGCTCTTTGAGAAATAGCTTATGAAAAGAATTGTTGGGGGTTTTTTTGGAAGAAGGGGCAGGTATGATCG
 241 GCAGGACACCCTGATAGGAAGAGGGGAAGCAGAAATCCAAGCACCACCAAACACAGTGTATGAAGGGGGGCGGTCATCAT
 321 TTCACTTGTCAGGAGTGTGTGTGAGTGTGAGTGTGCGGCTGTGTGTGCACGCGTGTGCAGGAGCGGCAGATGGGGAGACA
 401 ACGTGCTCTTTGTTTTGTGTCTCTTATGGATGTCCCCAGCAGAGAGGTTTGCAGTCCCAAGCGGTGTCTCTCCTGCCCCT
 481 TGGACACGCTCAGTGGGGCAGAGGCAGTACCTGGGCAAGCTGGCGGCTGGGGTCCCAGCAGCTGCCAGGAGCACGGCTCT
 561 GTCCCCAGCCTGGGAAAGCCCCTGCCCCTCCTCTCCCTCATCAAGGACACGGGCCTGTCCACAGGCTTCTGAGCAGCGAG
 641 CCTGCTAGTGGCCGAACCAGAACCAATTATTTTCATCCTTGTCTTATTCCCTTCCTGCCAGCCCCTGCCATTGTAGCGTC
 721 TTTCTTTTTTGGCCATCTGCTCCTGGATCTCCCTGAGATGGGCTTCCCAAGGGCTGCCGGGGCAGCCCCCTCACAGTATT
 801 GCTCACCCAGTGCCCTCTCCCCTCAGCCTCTCCCCTGCCTGCCCTGGTGACATCAGGTTTTTCCCGGACTTAGAAAACCA
 881 GCTCAGCACTGCCTGCTCCCATCCTGTGTGTTAAGCTCTGCTATTAGGCCAGCAAGCGGGGATGTCCCTGGGAGGGACAT
 961 GCTTAGCAGTCCCCTTCCCTCCAAGAAGGATTTGGTCCGTCATAACCCAAGGTACCATCCTAGGCTGACACCTAACTCTT
1041 CTTTCATTTCTTCTACAACTCATACACTCGTATGATACTTCGACACTGTTCTTAGCTCAATGAGCATGTTTAGACTTTAA
1121 CATAAGCTATTTTTCTAACTACAAAGGTTTAAATGAACAAGAGAAGCATTCTCATTGGAAATTTAGCATTGTAGTGCTTT
1201 GAGAGAGAAAGGACTCCTGAAAAAAAACCTGAGATTTATTAAAGAAAAAAATGTATTTTATGTTATATATAAATATATTA
1281 TTACTTGTAAATATAAAGACGTTTTATAAGCATCATTATTTATGTATTGTGCAATGTGTATAAACAAGAAAAATAAAGAA
1361 AAGATGCACTTTGCTTTAATATAAATGCAAATAACAAATGCCAAATTAAAAAAGATAAACACAAGATTGGTGTTTTTTTC
1441 TATGGGTGTTATCACCTAGCTGAATGTTTTTCTAAAGGAGTTTATGTTCCATTAAACGATTTTTAAAATGTACACTTGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacagggugggggUGAGGACa 5'
                       ||||||| 
Target 5' tgagagagaaaggACTCCTGa 3'
1200 - 1220 140.00 -10.10
2
miRNA  3' uacAGGGUGG-GGGUGAGGACa 5'
             |:: :|| :|::|||||| 
Target 5' tttTTTGGCCATCTGCTCCTGg 3'
725 - 746 138.00 -16.80
3
miRNA  3' uaCAGGGUGGG----GGUGAGGACa 5'
            ||||||  |    :| |||||| 
Target 5' caGTCCCAAGCGGTGTCTCTCCTGc 3'
452 - 476 129.00 -20.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30117139 5 COSMIC
COSN30154233 6 COSMIC
COSN31552803 8 COSMIC
COSN30131659 9 COSMIC
COSN30186255 73 COSMIC
COSN15665032 109 COSMIC
COSN16382586 466 COSMIC
COSN21759492 521 COSMIC
COSN22291135 554 COSMIC
COSN4623342 563 COSMIC
COSN1206703 701 COSMIC
COSN6416475 937 COSMIC
COSN1206701 1000 COSMIC
COSN31588484 1300 COSMIC
COSN1745264 1381 COSMIC
COSN31487884 1472 COSMIC
COSN31550707 1477 COSMIC
rs8088297 902 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772790276 2 dbSNP
rs775583726 3 dbSNP
rs201583721 4 dbSNP
rs369794757 5 dbSNP
rs755317709 6 dbSNP
rs1428389313 7 dbSNP
rs749695963 8 dbSNP
rs374817806 9 dbSNP
rs766164966 13 dbSNP
rs756388652 14 dbSNP
rs1440184659 16 dbSNP
rs1171934476 20 dbSNP
rs750412898 21 dbSNP
rs778140885 21 dbSNP
rs371306207 22 dbSNP
rs181999754 23 dbSNP
rs1316252128 25 dbSNP
rs752657520 29 dbSNP
rs765304819 32 dbSNP
rs1258477732 36 dbSNP
rs759399169 38 dbSNP
rs753742300 39 dbSNP
rs200839822 43 dbSNP
rs1400049104 45 dbSNP
rs1329922083 52 dbSNP
rs1283743692 55 dbSNP
rs1337513116 71 dbSNP
rs567738728 72 dbSNP
rs547981346 91 dbSNP
rs982928086 92 dbSNP
rs951470175 93 dbSNP
rs1335884012 99 dbSNP
rs1027069950 100 dbSNP
rs979479154 107 dbSNP
rs74509535 108 dbSNP
rs571323547 109 dbSNP
rs765070862 115 dbSNP
rs1197982886 119 dbSNP
rs370493054 119 dbSNP
rs536375171 119 dbSNP
rs992388714 122 dbSNP
rs1412018855 123 dbSNP
rs778041467 125 dbSNP
rs1472066198 126 dbSNP
rs902978500 127 dbSNP
rs1033820152 130 dbSNP
rs1455778228 132 dbSNP
rs758773034 139 dbSNP
rs1043200023 144 dbSNP
rs979815233 144 dbSNP
rs969874135 145 dbSNP
rs1027051537 148 dbSNP
rs1224702887 150 dbSNP
rs995153451 151 dbSNP
rs1327883166 155 dbSNP
rs896829875 162 dbSNP
rs878890171 171 dbSNP
rs748601975 172 dbSNP
rs1208992857 191 dbSNP
rs1015478376 192 dbSNP
rs1265027558 198 dbSNP
rs1453211826 198 dbSNP
rs1200066379 203 dbSNP
rs1411228682 207 dbSNP
rs1008154944 210 dbSNP
rs1161515173 211 dbSNP
rs1364578631 212 dbSNP
rs1449260248 213 dbSNP
rs1393337030 218 dbSNP
rs573781177 218 dbSNP
rs890956100 225 dbSNP
rs1246640381 227 dbSNP
rs1039347602 228 dbSNP
rs944310382 229 dbSNP
rs1049628100 239 dbSNP
rs1308572515 241 dbSNP
rs1317088300 243 dbSNP
rs1210821055 280 dbSNP
rs779429503 284 dbSNP
rs982981918 287 dbSNP
rs1490782977 296 dbSNP
rs951530184 297 dbSNP
rs1250948974 301 dbSNP
rs932704016 306 dbSNP
rs903965913 307 dbSNP
rs1178974657 311 dbSNP
rs189546111 311 dbSNP
rs35564009 311 dbSNP
rs556999027 311 dbSNP
rs150355680 312 dbSNP
rs753844398 313 dbSNP
rs1024082449 314 dbSNP
rs1370483183 316 dbSNP
rs142857154 318 dbSNP
rs959983848 330 dbSNP
rs1285897714 334 dbSNP
rs1299344649 344 dbSNP
rs765119352 344 dbSNP
rs998688184 344 dbSNP
rs1373431828 347 dbSNP
rs145497223 348 dbSNP
rs780241593 353 dbSNP
rs1011757663 354 dbSNP
rs1246415023 356 dbSNP
rs992338069 356 dbSNP
rs939641672 357 dbSNP
rs1436796512 366 dbSNP
rs1206546346 369 dbSNP
rs943676346 370 dbSNP
rs926792683 371 dbSNP
rs368597621 372 dbSNP
rs775619167 373 dbSNP
rs930183203 376 dbSNP
rs952324168 377 dbSNP
rs1188267726 380 dbSNP
rs1388739274 384 dbSNP
rs974253014 385 dbSNP
rs1026710294 393 dbSNP
rs571503155 401 dbSNP
rs961036154 402 dbSNP
rs1015301797 403 dbSNP
rs1164332812 409 dbSNP
rs1008145157 412 dbSNP
rs891070098 417 dbSNP
rs1296516753 423 dbSNP
rs1362788816 429 dbSNP
rs1216173316 440 dbSNP
rs1388676431 444 dbSNP
rs1208078815 446 dbSNP
rs1190963480 453 dbSNP
rs1265101525 455 dbSNP
rs1028146405 456 dbSNP
rs996664435 462 dbSNP
rs903704110 463 dbSNP
rs1043778717 466 dbSNP
rs1230581971 470 dbSNP
rs960696152 473 dbSNP
rs1246378318 478 dbSNP
rs1196775754 479 dbSNP
rs1453389069 481 dbSNP
rs1030924931 485 dbSNP
rs945462191 487 dbSNP
rs548990258 488 dbSNP
rs1319461663 489 dbSNP
rs1290762491 493 dbSNP
rs1270596796 495 dbSNP
rs529214054 497 dbSNP
rs1217433037 502 dbSNP
rs184768687 503 dbSNP
rs1324384914 505 dbSNP
rs939589179 508 dbSNP
rs539998882 523 dbSNP
rs1266468366 524 dbSNP
rs981005478 525 dbSNP
rs1216891940 533 dbSNP
rs1246525353 536 dbSNP
rs577419796 539 dbSNP
rs552059104 545 dbSNP
rs1430688628 549 dbSNP
rs1480478394 552 dbSNP
rs535005355 554 dbSNP
rs930235378 555 dbSNP
rs1318677679 562 dbSNP
rs866373251 563 dbSNP
rs1402962152 572 dbSNP
rs1332317455 576 dbSNP
rs898737420 583 dbSNP
rs1038978857 589 dbSNP
rs1429649867 591 dbSNP
rs138939641 594 dbSNP
rs1353067674 597 dbSNP
rs1224547509 600 dbSNP
rs1170830283 605 dbSNP
rs986493010 608 dbSNP
rs955038649 610 dbSNP
rs375444823 611 dbSNP
rs1180761751 613 dbSNP
rs763925170 637 dbSNP
rs967873794 638 dbSNP
rs762864884 642 dbSNP
rs1422509771 648 dbSNP
rs1165282103 653 dbSNP
rs1366063034 654 dbSNP
rs774651067 663 dbSNP
rs545528146 668 dbSNP
rs1482662747 671 dbSNP
rs892577041 673 dbSNP
rs1249530952 675 dbSNP
rs752578673 687 dbSNP
rs990427230 691 dbSNP
rs1283817231 692 dbSNP
rs963921287 695 dbSNP
rs1248600566 696 dbSNP
rs569535091 697 dbSNP
rs556551791 701 dbSNP
rs1307851206 711 dbSNP
rs1003473726 713 dbSNP
rs905202953 715 dbSNP
rs192920849 717 dbSNP
rs765243506 718 dbSNP
rs1181986362 725 dbSNP
rs1236502992 729 dbSNP
rs1442448162 731 dbSNP
rs574239134 731 dbSNP
rs920769571 732 dbSNP
rs1036960315 735 dbSNP
rs1166078526 740 dbSNP
rs1398635733 744 dbSNP
rs1410578101 755 dbSNP
rs554512204 761 dbSNP
rs1025345226 769 dbSNP
rs993828941 770 dbSNP
rs759575565 772 dbSNP
rs534341189 778 dbSNP
rs867509104 779 dbSNP
rs571913988 780 dbSNP
rs765701945 783 dbSNP
rs920940062 783 dbSNP
rs975349269 790 dbSNP
rs1277339724 792 dbSNP
rs551491617 794 dbSNP
rs561142803 797 dbSNP
rs1056532336 807 dbSNP
rs1448641490 809 dbSNP
rs1190812554 810 dbSNP
rs939459430 818 dbSNP
rs1158428965 822 dbSNP
rs924014223 826 dbSNP
rs878956924 830 dbSNP
rs968410924 833 dbSNP
rs796951448 834 dbSNP
rs1172026929 838 dbSNP
rs946735872 839 dbSNP
rs1471043683 841 dbSNP
rs771438561 852 dbSNP
rs112439201 865 dbSNP
rs146277807 866 dbSNP
rs990097554 873 dbSNP
rs1320747522 881 dbSNP
rs1327481127 883 dbSNP
rs1233165890 884 dbSNP
rs964282909 885 dbSNP
rs911082613 886 dbSNP
rs1035026085 890 dbSNP
rs1263346621 894 dbSNP
rs1263378036 898 dbSNP
rs1485370444 898 dbSNP
rs1227183987 900 dbSNP
rs8088297 902 dbSNP
rs1289722787 903 dbSNP
rs1198090209 909 dbSNP
rs1427182193 910 dbSNP
rs1481456085 912 dbSNP
rs905193164 915 dbSNP
rs1025398002 923 dbSNP
rs1451925344 928 dbSNP
rs993880028 936 dbSNP
rs190053734 937 dbSNP
rs995081325 938 dbSNP
rs1347981782 941 dbSNP
rs1406226422 942 dbSNP
rs899440273 947 dbSNP
rs1301418050 956 dbSNP
rs770475283 957 dbSNP
rs1450637697 958 dbSNP
rs1036629303 959 dbSNP
rs1407029557 961 dbSNP
rs1236431853 963 dbSNP
rs940815903 964 dbSNP
rs760185024 971 dbSNP
rs1351109479 974 dbSNP
rs1455910824 979 dbSNP
rs1390890918 987 dbSNP
rs1012516882 989 dbSNP
rs890631443 989 dbSNP
rs1490833887 996 dbSNP
rs1050799536 998 dbSNP
rs933764051 999 dbSNP
rs920939123 1002 dbSNP
rs1056585107 1012 dbSNP
rs1364668222 1017 dbSNP
rs566293487 1019 dbSNP
rs1457694865 1023 dbSNP
rs772870815 1029 dbSNP
rs1367953301 1032 dbSNP
rs915116619 1034 dbSNP
rs988075875 1038 dbSNP
rs1243598709 1041 dbSNP
rs749624876 1055 dbSNP
rs956502551 1065 dbSNP
rs1207676825 1066 dbSNP
rs1308687335 1067 dbSNP
rs1034849335 1069 dbSNP
rs1244943853 1070 dbSNP
rs982157343 1073 dbSNP
rs564213920 1076 dbSNP
rs1250749416 1081 dbSNP
rs142341429 1082 dbSNP
rs915265001 1094 dbSNP
rs1054392979 1099 dbSNP
rs995217995 1100 dbSNP
rs1215922814 1103 dbSNP
rs1387473255 1108 dbSNP
rs1445710823 1112 dbSNP
rs1168499482 1119 dbSNP
rs1321570381 1122 dbSNP
rs1460000471 1126 dbSNP
rs867700214 1127 dbSNP
rs1299433946 1140 dbSNP
rs911136945 1142 dbSNP
rs546537391 1144 dbSNP
rs1312561875 1147 dbSNP
rs1384708689 1148 dbSNP
rs1015553080 1152 dbSNP
rs16950113 1153 dbSNP
rs563976086 1158 dbSNP
rs890621645 1166 dbSNP
rs972520421 1174 dbSNP
rs1297383856 1175 dbSNP
rs1433145008 1177 dbSNP
rs962751172 1184 dbSNP
rs1245267262 1201 dbSNP
rs747666259 1207 dbSNP
rs1445620049 1209 dbSNP
rs879185043 1211 dbSNP
rs1417968493 1218 dbSNP
rs933711843 1224 dbSNP
rs1430833772 1225 dbSNP
rs16950112 1227 dbSNP
rs1035231577 1228 dbSNP
rs1423728000 1228 dbSNP
rs959649699 1228 dbSNP
rs1453069299 1229 dbSNP
rs1289483893 1230 dbSNP
rs1288094573 1238 dbSNP
rs1359725469 1248 dbSNP
rs1216258521 1250 dbSNP
rs1457476077 1252 dbSNP
rs1349173440 1253 dbSNP
rs1003709874 1269 dbSNP
rs1221836857 1272 dbSNP
rs1265202991 1274 dbSNP
rs1461975745 1274 dbSNP
rs1162585918 1276 dbSNP
rs1240751864 1278 dbSNP
rs1487098733 1280 dbSNP
rs1187627902 1284 dbSNP
rs1268884474 1290 dbSNP
rs1039470466 1295 dbSNP
rs1426517067 1298 dbSNP
rs780905443 1300 dbSNP
rs576456351 1301 dbSNP
rs1430909650 1324 dbSNP
rs1385609677 1331 dbSNP
rs1187721536 1332 dbSNP
rs1158015725 1334 dbSNP
rs1343225308 1341 dbSNP
rs1432710296 1344 dbSNP
rs1289374367 1359 dbSNP
rs914917289 1361 dbSNP
rs754655289 1362 dbSNP
rs988009729 1362 dbSNP
rs1324490683 1363 dbSNP
rs563609312 1365 dbSNP
rs1319100962 1367 dbSNP
rs1217004478 1380 dbSNP
rs1268770975 1398 dbSNP
rs1490008745 1399 dbSNP
rs779303060 1411 dbSNP
rs1270414798 1423 dbSNP
rs902696994 1427 dbSNP
rs935287635 1433 dbSNP
rs1021056932 1439 dbSNP
rs1487863271 1440 dbSNP
rs562855336 1442 dbSNP
rs1422704651 1446 dbSNP
rs1304963055 1448 dbSNP
rs981938635 1450 dbSNP
rs1224393980 1452 dbSNP
rs769033832 1452 dbSNP
rs1375861657 1453 dbSNP
rs1224635760 1465 dbSNP
rs1291542509 1466 dbSNP
rs184940583 1476 dbSNP
rs1024115378 1497 dbSNP
rs574083465 1498 dbSNP
rs1203261985 1512 dbSNP
rs1470973072 1514 dbSNP
rs973515464 1518 dbSNP
rs963674156 1519 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 4092.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 4092.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCCUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000262158.2 | 3UTR | CCACACUUCAAACUACUUUGCUGCUAAUAUUUUCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
256 hsa-miR-4433a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT088097 SEPT2 septin 2 2 2
MIRT143134 MGRN1 mahogunin ring finger 1 2 2
MIRT153912 NCOA3 nuclear receptor coactivator 3 2 2
MIRT154894 GNAS GNAS complex locus 2 4
MIRT200996 ZNF805 zinc finger protein 805 2 2
MIRT215729 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT235593 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT263250 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT317951 CDC5L cell division cycle 5 like 2 4
MIRT325572 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT354739 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT444552 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 4
MIRT446978 SUSD5 sushi domain containing 5 2 2
MIRT451036 ZNF610 zinc finger protein 610 2 2
MIRT451596 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT452025 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452594 CA6 carbonic anhydrase 6 2 2
MIRT452768 TCEA3 transcription elongation factor A3 2 4
MIRT452959 ZNF844 zinc finger protein 844 2 2
MIRT453191 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453382 RHD Rh blood group D antigen 2 2
MIRT453685 CEBPD CCAAT/enhancer binding protein delta 2 2
MIRT455272 DDX39B DExD-box helicase 39B 2 8
MIRT455346 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT456494 SERAC1 serine active site containing 1 2 2
MIRT456585 NID1 nidogen 1 2 2
MIRT456888 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457123 APOLD1 apolipoprotein L domain containing 1 2 2
MIRT457852 ZNF324B zinc finger protein 324B 2 2
MIRT457987 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT459278 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT459625 SLC25A33 solute carrier family 25 member 33 2 2
MIRT459715 SGK494 uncharacterized serine/threonine-protein kinase SgK494 2 2
MIRT460057 RPL22L1 ribosomal protein L22 like 1 2 2
MIRT460182 UNK unkempt family zinc finger 2 6
MIRT460288 PDE11A phosphodiesterase 11A 2 2
MIRT460841 EGF epidermal growth factor 2 4
MIRT460860 TBC1D19 TBC1 domain family member 19 2 2
MIRT461519 EMC7 ER membrane protein complex subunit 7 2 2
MIRT461729 SLC27A1 solute carrier family 27 member 1 2 4
MIRT461821 SNAP23 synaptosome associated protein 23 2 2
MIRT462066 CCDC77 coiled-coil domain containing 77 2 4
MIRT462084 MSANTD2 Myb/SANT DNA binding domain containing 2 2 2
MIRT462508 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 10
MIRT464239 VCP valosin containing protein 2 2
MIRT465316 TRAF5 TNF receptor associated factor 5 2 2
MIRT466549 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT467128 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT468091 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT469630 RAD21 RAD21 cohesin complex component 2 6
MIRT471097 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472704 MYBL1 MYB proto-oncogene like 1 2 2
MIRT472830 MTMR10 myotubularin related protein 10 2 2
MIRT472872 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT472895 MTDH metadherin 2 2
MIRT473728 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT473859 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474047 LONRF1 LON peptidase N-terminal domain and ring finger 1 2 2
MIRT474297 LAMC1 laminin subunit gamma 1 2 2
MIRT474658 KLF13 Kruppel like factor 13 2 2
MIRT475234 IKZF3 IKAROS family zinc finger 3 2 2
MIRT475500 HSP90B1 heat shock protein 90 beta family member 1 2 2
MIRT475742 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT475793 HDGF heparin binding growth factor 2 2
MIRT477254 ERGIC2 ERGIC and golgi 2 2 2
MIRT478228 DDX52 DExD-box helicase 52 2 2
MIRT478393 DCTN5 dynactin subunit 5 2 2
MIRT478754 CS citrate synthase 2 2
MIRT478827 CRKL CRK like proto-oncogene, adaptor protein 2 4
MIRT480234 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT480597 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT484121 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT484689 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486331 C11orf54 chromosome 11 open reading frame 54 2 4
MIRT488599 FAM3C family with sequence similarity 3 member C 2 8
MIRT488833 MRRF mitochondrial ribosome recycling factor 2 2
MIRT492523 RAB15 RAB15, member RAS oncogene family 2 4
MIRT493632 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500026 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501075 SMAD7 SMAD family member 7 2 8
MIRT503094 BTG2 BTG anti-proliferation factor 2 2 4
MIRT503336 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT505465 STMN1 stathmin 1 2 4
MIRT505726 SERTAD3 SERTA domain containing 3 2 4
MIRT509333 MS4A4A membrane spanning 4-domains A4A 2 2
MIRT509978 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 4
MIRT513068 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT513446 EMP1 epithelial membrane protein 1 2 6
MIRT513736 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT513996 CENPQ centromere protein Q 2 4
MIRT516538 MIXL1 Mix paired-like homeobox 2 2
MIRT517606 SAV1 salvador family WW domain containing protein 1 2 2
MIRT518064 CEP89 centrosomal protein 89 2 2
MIRT518119 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT518325 WDR92 WD repeat domain 92 2 2
MIRT519048 ABCB11 ATP binding cassette subfamily B member 11 2 2
MIRT520972 SPPL2A signal peptide peptidase like 2A 2 4
MIRT521359 RPL35A ribosomal protein L35a 2 2
MIRT523359 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT523801 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT524622 C7orf73 short transmembrane mitochondrial protein 1 2 2
MIRT525550 PHB2 prohibitin 2 2 4
MIRT529709 ZBTB49 zinc finger and BTB domain containing 49 2 2
MIRT531605 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT532387 UMPS uridine monophosphate synthetase 2 2
MIRT534468 SCD stearoyl-CoA desaturase 2 4
MIRT537546 ETNK1 ethanolamine kinase 1 2 2
MIRT541619 C11orf31 selenoprotein H 2 2
MIRT548380 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT549523 HDDC2 HD domain containing 2 2 2
MIRT549774 SOD2 superoxide dismutase 2 2 2
MIRT550578 SLC2A5 solute carrier family 2 member 5 2 2
MIRT551498 CENPN centromere protein N 2 4
MIRT552301 ITGA3 integrin subunit alpha 3 2 2
MIRT555400 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT556399 LUC7L LUC7 like 2 2
MIRT557047 HOXB3 homeobox B3 2 2
MIRT558072 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 2
MIRT559659 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT561239 ZNF354B zinc finger protein 354B 2 2
MIRT566899 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT568786 FAM120B family with sequence similarity 120B 2 2
MIRT574014 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT574885 Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 2 2
MIRT575243 Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 2
MIRT576194 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576309 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576484 Lhx4 LIM homeobox protein 4 2 3
MIRT576646 Mill2 MHC I like leukocyte 2 1 1
MIRT576708 Kras Kirsten rat sarcoma viral oncogene homolog 2 2
MIRT576855 Socs6 suppressor of cytokine signaling 6 2 2
MIRT576950 Aldoa aldolase A, fructose-bisphosphate 2 2
MIRT617133 ZNF556 zinc finger protein 556 2 4
MIRT617928 ZNF783 zinc finger family member 783 2 2
MIRT618981 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT621100 SIX3 SIX homeobox 3 2 2
MIRT624537 BROX BRO1 domain and CAAX motif containing 2 2
MIRT625663 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT627059 DCTN6 dynactin subunit 6 2 2
MIRT628319 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT630859 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT632295 TMEM65 transmembrane protein 65 2 2
MIRT634115 ZNF207 zinc finger protein 207 2 2
MIRT634736 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT635655 NDST3 N-deacetylase and N-sulfotransferase 3 2 2
MIRT635772 PDCL3 phosducin like 3 2 2
MIRT635911 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT636365 OGFRL1 opioid growth factor receptor like 1 2 4
MIRT637251 GLRX2 glutaredoxin 2 2 2
MIRT638705 FZD4 frizzled class receptor 4 2 2
MIRT639640 PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 2 2
MIRT639676 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT642267 SMIM17 small integral membrane protein 17 2 2
MIRT642372 ZNF581 zinc finger protein 581 2 2
MIRT643545 SLC25A17 solute carrier family 25 member 17 2 2
MIRT647994 PDE12 phosphodiesterase 12 2 2
MIRT649094 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT650993 ZNF770 zinc finger protein 770 2 2
MIRT651956 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT652977 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT654389 RBM12B RNA binding motif protein 12B 2 2
MIRT655637 OLFML2A olfactomedin like 2A 2 2
MIRT655729 NRXN3 neurexin 3 2 2
MIRT658171 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT660937 ACOX1 acyl-CoA oxidase 1 2 2
MIRT662112 CERKL ceramide kinase like 2 2
MIRT662302 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT662993 TMEM59 transmembrane protein 59 2 2
MIRT663071 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT663704 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663864 MUC20 mucin 20, cell surface associated 2 2
MIRT665185 HAUS5 HAUS augmin like complex subunit 5 2 4
MIRT665402 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT665688 TNPO3 transportin 3 2 2
MIRT665795 TMEM170A transmembrane protein 170A 2 2
MIRT665847 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT666999 PDPN podoplanin 2 2
MIRT667598 LIPC lipase C, hepatic type 2 2
MIRT668576 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT670960 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT671187 ZNF891 zinc finger protein 891 2 2
MIRT671739 ZNF451 zinc finger protein 451 2 2
MIRT672745 ZNF585B zinc finger protein 585B 2 4
MIRT673446 ZNF583 zinc finger protein 583 2 2
MIRT679843 GPR75 G protein-coupled receptor 75 2 2
MIRT680556 ZNF584 zinc finger protein 584 2 2
MIRT680661 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT681285 RFC2 replication factor C subunit 2 2 2
MIRT683264 ZNF329 zinc finger protein 329 2 2
MIRT684519 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT685065 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685157 DTWD2 DTW domain containing 2 2 2
MIRT685168 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT685470 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT686001 NEK4 NIMA related kinase 4 2 2
MIRT687027 RNF24 ring finger protein 24 2 2
MIRT687543 MOB1B MOB kinase activator 1B 2 2
MIRT687592 MANEAL mannosidase endo-alpha like 2 2
MIRT687753 KIAA1328 KIAA1328 2 2
MIRT688050 GLUL glutamate-ammonia ligase 2 2
MIRT688374 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT688802 CBFA2T3 CBFA2/RUNX1 translocation partner 3 2 2
MIRT688957 ATXN3 ataxin 3 2 2
MIRT689281 C5AR2 complement component 5a receptor 2 2 2
MIRT689988 NNMT nicotinamide N-methyltransferase 2 2
MIRT689997 MMP17 matrix metallopeptidase 17 2 2
MIRT690014 LUZP2 leucine zipper protein 2 2 2
MIRT690161 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690379 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT690563 MICA MHC class I polypeptide-related sequence A 2 2
MIRT691891 EVC EvC ciliary complex subunit 1 2 2
MIRT693107 SCNM1 sodium channel modifier 1 2 2
MIRT693832 ZFP64 ZFP64 zinc finger protein 2 2
MIRT694105 ZNF446 zinc finger protein 446 2 2
MIRT694179 ZNF486 zinc finger protein 486 2 2
MIRT694475 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT694998 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT695031 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695163 TCTN2 tectonic family member 2 2 2
MIRT695525 SLC25A34 solute carrier family 25 member 34 2 2
MIRT696067 ZNF264 zinc finger protein 264 2 2
MIRT696616 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT696661 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696705 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT697173 INMT indolethylamine N-methyltransferase 2 2
MIRT697303 ZNF652 zinc finger protein 652 2 2
MIRT697491 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT698657 TERF2 telomeric repeat binding factor 2 2 2
MIRT699042 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699185 SLX4IP SLX4 interacting protein 2 2
MIRT699598 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT700150 RNF115 ring finger protein 115 2 2
MIRT700720 PNO1 partner of NOB1 homolog 2 2
MIRT700870 PER2 period circadian clock 2 2 2
MIRT700912 PDXK pyridoxal kinase 2 2
MIRT701095 PAPOLG poly(A) polymerase gamma 2 2
MIRT701194 OTUD3 OTU deubiquitinase 3 2 2
MIRT702203 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702272 LHX4 LIM homeobox 4 2 3
MIRT703125 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT703252 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT703262 GNL3L G protein nucleolar 3 like 2 2
MIRT703440 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704321 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT704393 CTSS cathepsin S 2 2
MIRT704483 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT704880 CCSER2 coiled-coil serine rich protein 2 2 2
MIRT704926 CCDC36 coiled-coil domain containing 36 2 2
MIRT705175 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT706561 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT707048 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT711497 PGD phosphogluconate dehydrogenase 2 2
MIRT716644 EPGN epithelial mitogen 2 2
MIRT720083 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT722288 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT725468 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4433a Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4433a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4433a Vincristine 5978 approved resistant cell line (W1)
hsa-mir-4433a Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4433a-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4433a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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