miRTarBase - #MIRT502271


—
pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol HNRNPA1   
Synonyms ALS19, ALS20, HNRPA1, HNRPA1L3, IBMPFD3, UP 1, hnRNP A1, hnRNP-A1
Description heterogeneous nuclear ribonucleoprotein A1
Transcript NM_002136   
Other Transcripts NM_031157   
Expression
Putative miRNA Targets on HNRNPA1
3'UTR of HNRNPA1
(miRNA target sites are highlighted)		 
>HNRNPA1|NM_002136|3'UTR
   1 TTAGGAAACAAAGCTTAGCAGGAGAGGAGAGCCAGAGAAGTGACAGGGAAGCTACAGGTTACAACAGATTTGTGAACTCA
  81 GCCAAGCACAGTGGTGGCAGGGCCTAGCTGCTACAAAGAAGACATGTTTTAGACAAATACTCATGTGTATGGGCAAAAAA
 161 CTCGAGGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTCTGTGGAAAGTGTAAAGCATTCCAACA
 241 AAGGGTTTTAATGTAGATTTTTTTTTTTGCACCCCATGCTGTTGATTGCTAAATGTAACAGTCTGATCGTGACGCTGAAT
 321 AAATGTCTTTTTTTTAATGTGCTGTGTAAAGTTAGTCTACTCTTAAGCCATCTTGGTAAATTTCCCCAACAGTGTGAAGT
 401 TAGAATTCCTTCAGGGTGATGCCAGGTTCTATTTGGAATTTATATACAACCTGCTTGGGTGGAGAAGCCATTGTCTTCGG
 481 AAACCTTGGTGTAGTTGAACTGATAGTTACTGTTGTGACCTGAAGTTCACCATTAAAAGGGATTACCCAAGCAAAATCAT
 561 GGAATGGTTATAAAAGTGATTGTTGGCACATCCTATGCAATATATCTAAATTGAATAATGGTACCAGATAAAATTATAGA
 641 TGGGAATGAAGCTTGTGTATCCATTATCATGTGTAATCAATAAACGATTTAATTCTCTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augCGGU--CAG----UUAUGGAA-CACu 5'
             ||||  |||    :| ||||| ||| 
Target 5' gaaGCCATTGTCTTCGGAAACCTTGGTGt 3'
 464 - 492 127.00 -12.60
2 
miRNA  3' augcggucaguuaugGAACACu 5'
                         |||||| 
Target 5' tagatgggaatgaagCTTGTGt 3'
 637 - 658 120.00 -7.50
3 
miRNA  3' augcGGUCAG-UUAU-GGAACACu 5'
              ::|| | |||| :| |||| 
Target 5' tgttTTAGACAAATACTCATGTGt 3'
 125 - 148 110.00 -8.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31567743 2 COSMIC
COSN2378414 6 COSMIC
COSN26668072 7 COSMIC
COSN20077787 35 COSMIC
COSN19368807 52 COSMIC
COSN4891596 62 COSMIC
COSN5324147 62 COSMIC
COSN30597064 87 COSMIC
COSN16832030 122 COSMIC
COSN19689861 132 COSMIC
COSN7374205 145 COSMIC
COSN7374206 205 COSMIC
COSN1576756 237 COSMIC
COSN8586364 302 COSMIC
COSN9751732 382 COSMIC
COSN28642572 383 COSMIC
COSN9083787 470 COSMIC
COSN15661165 531 COSMIC
COSN28641992 550 COSMIC
COSN31563453 596 COSMIC
COSN9083788 598 COSMIC
COSN19408136 657 COSMIC
COSN26677164 852 COSMIC
COSN16098602 898 COSMIC
COSN32137374 1051 COSMIC
COSN31663621 1230 COSMIC
COSN14598016 1426 COSMIC
COSN18714720 1605 COSMIC
COSN9563866 1739 COSMIC
COSN7616944 1883 COSMIC
COSN29861951 1917 COSMIC
COSN26234338 2079 COSMIC
COSN2492750 2083 COSMIC
COSN5946563 2236 COSMIC
COSN15136880 2418 COSMIC
COSN6616414 2627 COSMIC
COSN24991795 2693 COSMIC
COSN26883119 2746 COSMIC
COSN1149593 2755 COSMIC
COSN29008192 2755 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1381345475 3 dbSNP
rs1402469304 4 dbSNP
rs764587450 5 dbSNP
rs1256125188 7 dbSNP
rs1467973612 13 dbSNP
rs1483928902 13 dbSNP
rs185440272 14 dbSNP
rs1242130123 17 dbSNP
rs1465643777 19 dbSNP
rs762411249 26 dbSNP
rs1026348474 30 dbSNP
rs1449345614 32 dbSNP
rs768062002 34 dbSNP
rs1379491777 36 dbSNP
rs781170901 37 dbSNP
rs1172221404 40 dbSNP
rs1176834178 46 dbSNP
rs750522774 47 dbSNP
rs756191880 48 dbSNP
rs1322241695 50 dbSNP
rs376830001 51 dbSNP
rs754089897 52 dbSNP
rs1299949444 56 dbSNP
rs1199883000 59 dbSNP
rs1374203368 62 dbSNP
rs544977777 63 dbSNP
rs371452672 66 dbSNP
rs1340701088 67 dbSNP
rs867828035 68 dbSNP
rs926866372 79 dbSNP
rs938238604 81 dbSNP
rs532880784 90 dbSNP
rs1394231723 99 dbSNP
rs761275864 99 dbSNP
rs1166242775 100 dbSNP
rs1475088161 102 dbSNP
rs1386129464 104 dbSNP
rs1185602604 111 dbSNP
rs1442986328 114 dbSNP
rs1357607340 118 dbSNP
rs1234236423 123 dbSNP
rs548076577 134 dbSNP
rs780632286 143 dbSNP
rs1042526084 152 dbSNP
rs1271416699 153 dbSNP
rs1194762099 156 dbSNP
rs575983828 158 dbSNP
rs1207288690 160 dbSNP
rs1252548157 166 dbSNP
rs903541582 166 dbSNP
rs1483129922 167 dbSNP
rs936308845 173 dbSNP
rs1381579229 184 dbSNP
rs1180845280 185 dbSNP
rs755142260 188 dbSNP
rs1313501614 190 dbSNP
rs1328057150 195 dbSNP
rs778691498 196 dbSNP
rs1409476097 202 dbSNP
rs775703600 208 dbSNP
rs1415620882 213 dbSNP
rs1262128101 214 dbSNP
rs1329376871 216 dbSNP
rs1210998987 228 dbSNP
rs889725441 241 dbSNP
rs537037310 246 dbSNP
rs1403395659 248 dbSNP
rs1485730415 263 dbSNP
rs1192341055 282 dbSNP
rs1008109174 302 dbSNP
rs758335427 309 dbSNP
rs1431513889 311 dbSNP
rs777753412 318 dbSNP
rs1019452635 319 dbSNP
rs1459064605 326 dbSNP
rs1157177525 366 dbSNP
rs1386269149 372 dbSNP
rs1452773874 373 dbSNP
rs896972665 374 dbSNP
rs1369560866 376 dbSNP
rs1219604320 379 dbSNP
rs1384601070 383 dbSNP
rs993636555 386 dbSNP
rs1026800612 395 dbSNP
rs1403508288 396 dbSNP
rs1225287850 403 dbSNP
rs1172532198 413 dbSNP
rs952078362 415 dbSNP
rs1278715152 449 dbSNP
rs1437158078 454 dbSNP
rs1347320360 458 dbSNP
rs1305100986 474 dbSNP
rs1403121543 477 dbSNP
rs1429108948 481 dbSNP
rs1306289489 488 dbSNP
rs1033619097 489 dbSNP
rs533212482 489 dbSNP
rs879367409 489 dbSNP
rs918129644 489 dbSNP
rs992810065 489 dbSNP
rs967260398 496 dbSNP
rs1357553196 497 dbSNP
rs1481083639 500 dbSNP
rs1271607881 501 dbSNP
rs1196656914 510 dbSNP
rs1490032670 512 dbSNP
rs1242363528 520 dbSNP
rs3953255 531 dbSNP
rs1217560775 532 dbSNP
rs977896953 535 dbSNP
rs1283939819 540 dbSNP
rs558097327 541 dbSNP
rs3953256 545 dbSNP
rs1216816996 546 dbSNP
rs576751121 548 dbSNP
rs1281231786 552 dbSNP
rs1221784038 559 dbSNP
rs1345018035 559 dbSNP
rs1135894 567 dbSNP
rs1289487734 568 dbSNP
rs1433230906 571 dbSNP
rs1343640128 576 dbSNP
rs936381093 595 dbSNP
rs4016669 596 dbSNP
rs1470468145 600 dbSNP
rs1432120302 602 dbSNP
rs1049425287 609 dbSNP
rs910857147 618 dbSNP
rs1419661956 622 dbSNP
rs1187760820 624 dbSNP
rs943970990 629 dbSNP
rs1241105304 640 dbSNP
rs1041357434 645 dbSNP
rs1271889353 649 dbSNP
rs10652 656 dbSNP
rs897011334 659 dbSNP
rs1202998470 663 dbSNP
rs113736551 670 dbSNP
rs1048199361 699 dbSNP
rs1453867125 700 dbSNP
rs4118339 701 dbSNP
rs1408825211 702 dbSNP
rs1335104986 704 dbSNP
rs1469799757 707 dbSNP
rs4016670 710 dbSNP
rs1006225712 711 dbSNP
rs1418392944 713 dbSNP
rs1183869703 715 dbSNP
rs1033673108 716 dbSNP
rs559999647 717 dbSNP
rs1241109952 725 dbSNP
rs959362016 729 dbSNP
rs1182733890 730 dbSNP
rs1480925920 732 dbSNP
rs1188065812 735 dbSNP
rs559132230 738 dbSNP
rs1390664594 742 dbSNP
rs1013859530 744 dbSNP
rs1025634247 753 dbSNP
rs1448810972 754 dbSNP
rs1247045320 756 dbSNP
rs1385258044 760 dbSNP
rs181507184 768 dbSNP
rs1166768627 779 dbSNP
rs4118338 783 dbSNP
rs4118337 788 dbSNP
rs1374704715 794 dbSNP
rs966957554 804 dbSNP
rs866056457 809 dbSNP
rs1377391142 811 dbSNP
rs1460048449 813 dbSNP
rs1353452509 818 dbSNP
rs1163658228 822 dbSNP
rs1426222058 824 dbSNP
rs542005675 825 dbSNP
rs925402477 832 dbSNP
rs1333822659 838 dbSNP
rs1357656521 845 dbSNP
rs766892723 848 dbSNP
rs1346136241 852 dbSNP
rs985199033 853 dbSNP
rs1175462078 855 dbSNP
rs1365043670 859 dbSNP
rs4016671 863 dbSNP
rs1226907367 869 dbSNP
rs910930600 874 dbSNP
rs1361884634 875 dbSNP
rs745432514 885 dbSNP
rs1317850375 888 dbSNP
rs1219439322 889 dbSNP
rs4016672 890 dbSNP
rs918514512 893 dbSNP
rs929888299 894 dbSNP
rs563781412 899 dbSNP
rs1048220401 900 dbSNP
rs1303240127 901 dbSNP
rs867852317 903 dbSNP
rs1363362768 909 dbSNP
rs140633160 917 dbSNP
rs1453976719 918 dbSNP
rs1217613427 919 dbSNP
rs1156662675 921 dbSNP
rs1418493277 927 dbSNP
rs1429841573 931 dbSNP
rs546193833 934 dbSNP
rs868281539 935 dbSNP
rs371332286 941 dbSNP
rs1490850237 943 dbSNP
rs55706371 945 dbSNP
rs1267069336 956 dbSNP
rs1248462515 967 dbSNP
rs1291933106 973 dbSNP
rs1464359756 974 dbSNP
rs1209523791 979 dbSNP
rs1186666516 982 dbSNP
rs1262922895 985 dbSNP
rs1237259619 986 dbSNP
rs1329080042 993 dbSNP
rs1284440574 994 dbSNP
rs1396951544 995 dbSNP
rs1478363461 997 dbSNP
rs1322273887 999 dbSNP
rs113463590 1002 dbSNP
rs528796027 1003 dbSNP
rs895177637 1007 dbSNP
rs1402685700 1010 dbSNP
rs1452704298 1015 dbSNP
rs1321620311 1018 dbSNP
rs1233912480 1032 dbSNP
rs1178446526 1036 dbSNP
rs184630270 1038 dbSNP
rs1024950463 1041 dbSNP
rs568707896 1049 dbSNP
rs1264038342 1051 dbSNP
rs1203786384 1052 dbSNP
rs1464689507 1061 dbSNP
rs999748174 1064 dbSNP
rs1372385741 1072 dbSNP
rs1436495138 1074 dbSNP
rs1322029890 1075 dbSNP
rs780110414 1078 dbSNP
rs767938981 1079 dbSNP
rs1342404229 1090 dbSNP
rs1032546016 1091 dbSNP
rs111768814 1092 dbSNP
rs1018025386 1094 dbSNP
rs1468216884 1096 dbSNP
rs965129359 1097 dbSNP
rs548016860 1098 dbSNP
rs1254740768 1105 dbSNP
rs1191363386 1115 dbSNP
rs1449056543 1116 dbSNP
rs1244206412 1121 dbSNP
rs768152588 1125 dbSNP
rs983998653 1128 dbSNP
rs1278457299 1129 dbSNP
rs1198191508 1132 dbSNP
rs1340800571 1134 dbSNP
rs1249093817 1136 dbSNP
rs1245108958 1138 dbSNP
rs1471263554 1141 dbSNP
rs1316904858 1143 dbSNP
rs1450102834 1147 dbSNP
rs1339832749 1151 dbSNP
rs909741861 1154 dbSNP
rs937160313 1155 dbSNP
rs138310298 1156 dbSNP
rs1166791380 1157 dbSNP
rs536721561 1159 dbSNP
rs1429416401 1165 dbSNP
rs1386031425 1170 dbSNP
rs895238207 1172 dbSNP
rs945161045 1185 dbSNP
rs1237438056 1188 dbSNP
rs1167561906 1189 dbSNP
rs773914335 1191 dbSNP
rs1042509223 1200 dbSNP
rs1405338769 1204 dbSNP
rs1322269482 1208 dbSNP
rs903354924 1215 dbSNP
rs1008365949 1219 dbSNP
rs1247892639 1222 dbSNP
rs1411261005 1223 dbSNP
rs1203734273 1229 dbSNP
rs902504837 1235 dbSNP
rs1293440912 1242 dbSNP
rs767053244 1243 dbSNP
rs1355438750 1247 dbSNP
rs1000225571 1254 dbSNP
rs1349499500 1261 dbSNP
rs189523819 1264 dbSNP
rs1306276410 1265 dbSNP
rs1274838864 1280 dbSNP
rs768428131 1287 dbSNP
rs1366464162 1289 dbSNP
rs894007567 1293 dbSNP
rs1403795829 1294 dbSNP
rs1356937160 1303 dbSNP
rs1413581525 1309 dbSNP
rs1159509738 1319 dbSNP
rs997492302 1323 dbSNP
rs1410308572 1332 dbSNP
rs1007078649 1334 dbSNP
rs1490355795 1337 dbSNP
rs1018431689 1338 dbSNP
rs1026998836 1339 dbSNP
rs952798314 1343 dbSNP
rs976497287 1350 dbSNP
rs1004303054 1354 dbSNP
rs1025769835 1364 dbSNP
rs1225200795 1370 dbSNP
rs1348462072 1371 dbSNP
rs1183007622 1375 dbSNP
rs1251276171 1376 dbSNP
rs1471754090 1381 dbSNP
rs113017899 1382 dbSNP
rs1190482191 1386 dbSNP
rs548441388 1386 dbSNP
rs570075446 1389 dbSNP
rs534640891 1390 dbSNP
rs1319391211 1393 dbSNP
rs1402758956 1400 dbSNP
rs970775994 1401 dbSNP
rs552844808 1403 dbSNP
rs574573847 1410 dbSNP
rs1430876969 1415 dbSNP
rs1188937170 1416 dbSNP
rs1162034975 1417 dbSNP
rs1399273953 1421 dbSNP
rs937235360 1427 dbSNP
rs926437983 1428 dbSNP
rs570118696 1429 dbSNP
rs747201540 1430 dbSNP
rs991283287 1437 dbSNP
rs1369504019 1442 dbSNP
rs771323977 1444 dbSNP
rs796651892 1451 dbSNP
rs776821116 1453 dbSNP
rs1348887903 1456 dbSNP
rs1363512802 1459 dbSNP
rs180704694 1460 dbSNP
rs949533383 1467 dbSNP
rs1340914659 1471 dbSNP
rs556843142 1478 dbSNP
rs1408866421 1479 dbSNP
rs1046473902 1481 dbSNP
rs1282301934 1482 dbSNP
rs944998112 1484 dbSNP
rs1419818829 1485 dbSNP
rs866927948 1494 dbSNP
rs1187951418 1502 dbSNP
rs564982932 1504 dbSNP
rs911678703 1507 dbSNP
rs1247261763 1510 dbSNP
rs944437160 1512 dbSNP
rs1183960388 1514 dbSNP
rs1462612191 1525 dbSNP
rs1254127395 1529 dbSNP
rs1208134876 1530 dbSNP
rs1341397955 1534 dbSNP
rs1273761368 1536 dbSNP
rs1216614059 1544 dbSNP
rs1205914465 1546 dbSNP
rs952204406 1548 dbSNP
rs1389041673 1549 dbSNP
rs1385662019 1552 dbSNP
rs1474110261 1552 dbSNP
rs1482176884 1554 dbSNP
rs1164978480 1555 dbSNP
rs1213370379 1555 dbSNP
rs1447919511 1556 dbSNP
rs1354653721 1558 dbSNP
rs1004951335 1559 dbSNP
rs1391321272 1559 dbSNP
rs1041261786 1561 dbSNP
rs1404618141 1562 dbSNP
rs1253788157 1566 dbSNP
rs1446175838 1566 dbSNP
rs898900085 1566 dbSNP
rs1181246813 1568 dbSNP
rs994626160 1569 dbSNP
rs1023463625 1573 dbSNP
rs1297079751 1577 dbSNP
rs1480914735 1577 dbSNP
rs1233580379 1580 dbSNP
rs1207310074 1586 dbSNP
rs1423541227 1590 dbSNP
rs1274143109 1596 dbSNP
rs1247202678 1597 dbSNP
rs1323931602 1603 dbSNP
rs575713387 1605 dbSNP
rs1375245845 1611 dbSNP
rs765823708 1613 dbSNP
rs1374678380 1615 dbSNP
rs149141494 1619 dbSNP
rs1007109930 1620 dbSNP
rs1407384698 1624 dbSNP
rs528553227 1643 dbSNP
rs1303426844 1645 dbSNP
rs901335521 1654 dbSNP
rs997126084 1656 dbSNP
rs1025377103 1657 dbSNP
rs564478719 1665 dbSNP
rs528483188 1666 dbSNP
rs1410000749 1668 dbSNP
rs1184466016 1674 dbSNP
rs1016514963 1676 dbSNP
rs958623192 1677 dbSNP
rs1004653677 1679 dbSNP
rs1223563258 1686 dbSNP
rs1489579718 1687 dbSNP
rs1264121785 1693 dbSNP
rs1221207527 1697 dbSNP
rs1290717797 1706 dbSNP
rs991356922 1720 dbSNP
rs540957582 1750 dbSNP
rs1015544086 1751 dbSNP
rs1388221145 1753 dbSNP
rs1388047779 1758 dbSNP
rs1292744627 1761 dbSNP
rs146354980 1762 dbSNP
rs1003572208 1763 dbSNP
rs1472210552 1770 dbSNP
rs1411399776 1773 dbSNP
rs1200223932 1776 dbSNP
rs1331988768 1776 dbSNP
rs1435129382 1777 dbSNP
rs971236789 1778 dbSNP
rs1033488368 1793 dbSNP
rs1367214840 1796 dbSNP
rs982635114 1803 dbSNP
rs1229099690 1834 dbSNP
rs1296956798 1835 dbSNP
rs1263225206 1836 dbSNP
rs1340199877 1839 dbSNP
rs924063923 1840 dbSNP
rs1329019250 1841 dbSNP
rs1235525548 1844 dbSNP
rs1367157127 1846 dbSNP
rs1318279611 1848 dbSNP
rs1456700140 1856 dbSNP
rs756881148 1870 dbSNP
rs767200321 1873 dbSNP
rs1053790375 1882 dbSNP
rs1467601948 1884 dbSNP
rs1483064864 1900 dbSNP
rs1198488452 1903 dbSNP
rs989417462 1915 dbSNP
rs1250368312 1916 dbSNP
rs1264356663 1918 dbSNP
rs1465719156 1924 dbSNP
rs1188561151 1927 dbSNP
rs915109955 1929 dbSNP
rs1464852656 1934 dbSNP
rs1244239019 1948 dbSNP
rs915214010 1951 dbSNP
rs966645844 1952 dbSNP
rs977793413 1953 dbSNP
rs1227778207 1963 dbSNP
rs1295132764 1968 dbSNP
rs1343848506 1968 dbSNP
rs969216369 1984 dbSNP
rs1434010428 1991 dbSNP
rs1383463584 1992 dbSNP
rs749934568 1993 dbSNP
rs942968072 1993 dbSNP
rs911542929 1995 dbSNP
rs1039935496 2000 dbSNP
rs552561618 2003 dbSNP
rs1430653580 2005 dbSNP
rs1447072431 2007 dbSNP
rs998376084 2007 dbSNP
rs547014213 2009 dbSNP
rs1177613482 2012 dbSNP
rs1377806727 2015 dbSNP
rs1047649051 2017 dbSNP
rs886860992 2019 dbSNP
rs570478089 2023 dbSNP
rs1005224232 2025 dbSNP
rs139179873 2027 dbSNP
rs1441176122 2031 dbSNP
rs1254952314 2032 dbSNP
rs755681192 2034 dbSNP
rs1195801363 2040 dbSNP
rs1016588836 2055 dbSNP
rs921433846 2060 dbSNP
rs958361589 2067 dbSNP
rs1359955400 2068 dbSNP
rs1435703429 2073 dbSNP
rs1013274474 2075 dbSNP
rs1024212848 2078 dbSNP
rs1333611311 2080 dbSNP
rs1410463418 2082 dbSNP
rs1372676166 2088 dbSNP
rs186449759 2097 dbSNP
rs569306243 2099 dbSNP
rs1048545874 2103 dbSNP
rs1302099444 2105 dbSNP
rs1311802938 2110 dbSNP
rs1231388168 2115 dbSNP
rs888733046 2117 dbSNP
rs1472097476 2118 dbSNP
rs1368339184 2121 dbSNP
rs530640819 2123 dbSNP
rs940266064 2126 dbSNP
rs1473261825 2128 dbSNP
rs1248941930 2130 dbSNP
rs977301058 2132 dbSNP
rs1490411448 2133 dbSNP
rs1330319208 2140 dbSNP
rs1208513882 2151 dbSNP
rs778907261 2155 dbSNP
rs924402192 2167 dbSNP
rs1230119376 2169 dbSNP
rs1352460143 2173 dbSNP
rs551845937 2180 dbSNP
rs1286515197 2181 dbSNP
rs1409515552 2182 dbSNP
rs1350616216 2183 dbSNP
rs1325955531 2184 dbSNP
rs571559475 2187 dbSNP
rs570159545 2188 dbSNP
rs1037021490 2197 dbSNP
rs906516929 2198 dbSNP
rs1160601578 2199 dbSNP
rs1192384068 2204 dbSNP
rs1448464799 2214 dbSNP
rs538567027 2217 dbSNP
rs1267504631 2218 dbSNP
rs1180747967 2231 dbSNP
rs117046077 2235 dbSNP
rs1432226352 2239 dbSNP
rs1003603418 2244 dbSNP
rs12656 2246 dbSNP
rs1450862387 2250 dbSNP
rs1284668850 2252 dbSNP
rs191215922 2253 dbSNP
rs1326990459 2254 dbSNP
rs1266318368 2267 dbSNP
rs1227796395 2275 dbSNP
rs1457510994 2278 dbSNP
rs1276788017 2280 dbSNP
rs1434538583 2283 dbSNP
rs1158185944 2284 dbSNP
rs1330932541 2284 dbSNP
rs868276883 2299 dbSNP
rs1459423529 2301 dbSNP
rs942662341 2304 dbSNP
rs1426627089 2310 dbSNP
rs1170498872 2312 dbSNP
rs1011190426 2317 dbSNP
rs1477484845 2318 dbSNP
rs1040080321 2319 dbSNP
rs80251270 2325 dbSNP
rs754892078 2327 dbSNP
rs181906119 2332 dbSNP
rs1367078377 2335 dbSNP
rs1280793351 2338 dbSNP
rs1385297026 2341 dbSNP
rs1344504995 2351 dbSNP
rs73304521 2357 dbSNP
rs1047234010 2359 dbSNP
rs557119450 2362 dbSNP
rs1266653413 2363 dbSNP
rs1005297903 2364 dbSNP
rs1360447663 2370 dbSNP
rs1331618569 2373 dbSNP
rs1413558792 2378 dbSNP
rs1324009758 2381 dbSNP
rs1170276291 2382 dbSNP
rs568396188 2387 dbSNP
rs1389283375 2402 dbSNP
rs967053327 2404 dbSNP
rs778743480 2406 dbSNP
rs1484185027 2407 dbSNP
rs1018639459 2408 dbSNP
rs187122180 2409 dbSNP
rs974498093 2410 dbSNP
rs747993578 2415 dbSNP
rs1340548047 2419 dbSNP
rs771272958 2430 dbSNP
rs1297305574 2437 dbSNP
rs539977045 2438 dbSNP
rs984717697 2439 dbSNP
rs191500648 2440 dbSNP
rs111253751 2447 dbSNP
rs1446584768 2457 dbSNP
rs957192125 2459 dbSNP
rs910037523 2460 dbSNP
rs940291622 2461 dbSNP
rs1037223914 2462 dbSNP
rs772017484 2463 dbSNP
rs1165140354 2464 dbSNP
rs906548218 2469 dbSNP
rs989590043 2475 dbSNP
rs1409536469 2481 dbSNP
rs573312088 2488 dbSNP
rs1022399063 2490 dbSNP
rs1425482487 2493 dbSNP
rs1055041670 2506 dbSNP
rs1349240523 2507 dbSNP
rs540649275 2509 dbSNP
rs895262572 2511 dbSNP
rs561909173 2512 dbSNP
rs574280273 2517 dbSNP
rs1371352124 2519 dbSNP
rs544539332 2525 dbSNP
rs552799834 2526 dbSNP
rs934293925 2529 dbSNP
rs983435667 2529 dbSNP
rs908738693 2533 dbSNP
rs1018837465 2535 dbSNP
rs1407681371 2540 dbSNP
rs1229257986 2541 dbSNP
rs1038472789 2549 dbSNP
rs1459217209 2558 dbSNP
rs777050841 2569 dbSNP
rs974445613 2570 dbSNP
rs1028639456 2571 dbSNP
rs1412881531 2575 dbSNP
rs143091756 2577 dbSNP
rs1045411076 2581 dbSNP
rs1471740296 2581 dbSNP
rs906856662 2582 dbSNP
rs183364059 2583 dbSNP
rs1264021309 2588 dbSNP
rs984526977 2592 dbSNP
rs1204075277 2596 dbSNP
rs1269496859 2597 dbSNP
rs1225991436 2599 dbSNP
rs1316004412 2605 dbSNP
rs1230958862 2611 dbSNP
rs1388128798 2614 dbSNP
rs1365300995 2616 dbSNP
rs1324970889 2617 dbSNP
rs910059997 2619 dbSNP
rs1484073020 2620 dbSNP
rs551880122 2622 dbSNP
rs1031576300 2625 dbSNP
rs1390670901 2625 dbSNP
rs1455673309 2629 dbSNP
rs111805463 2638 dbSNP
rs1363269651 2644 dbSNP
rs893027826 2645 dbSNP
rs563823392 2646 dbSNP
rs1011431602 2657 dbSNP
rs1193317642 2660 dbSNP
rs940154395 2661 dbSNP
rs1017408182 2669 dbSNP
rs1207356570 2672 dbSNP
rs964168068 2673 dbSNP
rs975894586 2677 dbSNP
rs1029702472 2681 dbSNP
rs528139096 2682 dbSNP
rs1302430719 2683 dbSNP
rs746099913 2687 dbSNP
rs77993769 2695 dbSNP
rs1367303527 2698 dbSNP
rs1449151715 2702 dbSNP
rs1381556842 2705 dbSNP
rs147199419 2706 dbSNP
rs6717 2710 dbSNP
rs1384418175 2712 dbSNP
rs972967653 2719 dbSNP
rs1467776051 2721 dbSNP
rs928256290 2724 dbSNP
rs769926860 2725 dbSNP
rs1392395058 2727 dbSNP
rs1187291600 2728 dbSNP
rs1299162072 2731 dbSNP
rs1055561434 2733 dbSNP
rs1256252087 2739 dbSNP
rs916573676 2741 dbSNP
rs200425263 2742 dbSNP
rs1201616566 2744 dbSNP
rs140728579 2744 dbSNP
rs201857164 2745 dbSNP
rs1043776989 2750 dbSNP
rs902350264 2755 dbSNP
rs948533591 2762 dbSNP
rs535748240 2769 dbSNP
rs1236718203 2772 dbSNP
rs550588303 2772 dbSNP
rs569078515 2775 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggucaguuauGGAACACu 5'
                        ||||||| 
Target 5' -------------uCCUUGUGa 3'
 		1 - 9
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggucaguuauGGAACACu 5'
                        ||||||| 
Target 5' -------------uCCUUGUGa 3'
 		1 - 9
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177605. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_7 PAR-CLIP data was present in ERX177608. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_10 PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177620. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_10 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177631. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_9 PAR-CLIP data was present in ERX177632. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_10 PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2 PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177607. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_9 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000546500.1 | 3UTR | UCCUUGUGAAGACCUUUAUCUGAGCCACUGUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000546500.1 | 3UTR | UCCUUGUGAAGACCUUUAUCUGAGCCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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