pre-miRNA Information
pre-miRNA hsa-mir-4524a   
Genomic Coordinates chr17: 69099564 - 69099632
Description Homo sapiens miR-4524a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524a-5p
Sequence 6| AUAGCAGCAUGAACCUGUCUCA |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322445998 8 dbSNP
rs1350790266 13 dbSNP
rs1263495678 21 dbSNP
Putative Targets

Gene Information
Gene Symbol DDX3X   
Synonyms CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102
Description DEAD-box helicase 3, X-linked
Transcript NM_001356   
Expression
Putative miRNA Targets on DDX3X
3'UTR of DDX3X
(miRNA target sites are highlighted)
>DDX3X|NM_001356|3'UTR
   1 GCCTGCTTTGCAGTAGGTCACCCTGCCAAACAAGCTAATATGGAAACCACATGTAACTTAGCCAGACTATACCTTGTGTA
  81 GCTTCAAGAACTCGCAGTACATTACCAGCTGTGATTCTCCACTGAAATTTTTTTTTTAAGGGAGCTCAAGGTCACAAGAA
 161 GAAATGAAAGGAACAATCAGCAGCCCTGTTCAGAAGGTGGTTTGAAGACTTCATTGCTGTAGTTTGGATTAACTCCCCTC
 241 CCGCCTACCCCCATCCCAAACTGCATTTATAATTTTGTGACTGAGGATCATTTGTTTGTTAATGTACTGTGCCTTTAACT
 321 TTAGACAACTTTTTATTTTGATGTCCTGTTGGCTCAGTAATGCTCAAGATATCAATTGTTTTGACAAAATAAATTTACTG
 401 AACTTGGGCTAAAATCAAACCTTGGCACACAGGTGTGATACAACTTAACAGGAATCATCGATTCATCCATAAATAATATA
 481 AGGAAAAACTTATGCGGTAGCCTGCATTAGGGCTTTTTGATACTTGCAGATTGGGGGAAAACAACAAATGTCTTGAAGCA
 561 TATTAATGGAATTAGTTTCTAATGTGGCAAACTGTATTAAGTTAAAGTTCTGATTTGCTCACTCTATCCTGGATAGGTAT
 641 TTAGAACCTGATAGTCTTTAAGCCATTCCAGTCATGATGAGGTGATGTATGAATACATGCATACATTCAAAGCACTGTTT
 721 TCAAAGTTAATGCAAGTAAATACAGCAATTCCTCTTTCAACGTTTAGGCAGATCATTAATTATGAGCTAGCCAAATGTGG
 801 GCATACTATTACAGGGAAAGTTTAAAGGTCTGATAACTTGAAATAGGTTTTTAGGAGAATTCATCTACTTAGACTTTTTA
 881 AATGCCTGCCATAAATGAAATTGAAATGGTAGAATGGCTGACCACAGCAATGACCAGCCCTCATTAGGGCCCTGGATGAT
 961 TTTTGGTCTAATAACGCATGCTAGTGTTGATGTTTTTTGGTCAAGAGGGTATGAACAGGAAGAATTAAATGCAGCAGGCT
1041 TTATTTTAAATGCCGATTCACATTACTCTGTTCAAGCTGCGTTGAGATGTTAAACTGGCTTACTATAGACTTCGTAAAAA
1121 TGGCTCCAGAAGAGTAACAAACTGAAATCTTTGAGATCACACAGGTTGGAAATATGTACATAACTGCACAAGGTGTCAAT
1201 TCTGCTCTACAGTGCAGTTTTAGTCAGTTTTAGTTGCATAGGTTTCCATTGTATTTATAGTCTGTTTATGCTAAATCTGG
1281 CCAAAGATGAGCATTGTCCACCACTAAAATGCCTCTGCCACTTTGAATTCTGTGCTAATTTTGTGGCCAGAATGCGGTGA
1361 TCAAAACGCTCCATCTTTTTACAGTGGCATAGGAAGACGGCAAAAATTTCCTAAAGTGCAATAGATTTTCAAGTGTATTG
1441 TGCCTTGTTCTAAAACTTTTATTAAGTAGGTGCACTTGACAGTATTGAGGTCATTTGTTATGGTGCTATTTCAATTAGTC
1521 TAGGTTTAGGCCCTTGTACATTTTGCCCATAACTTTTTACAAAGTACTTCTTTTATTGCACATTCAGAGAATTTTATATA
1601 TATGTCTTGTGTGCGTGTCCTTAAACTTCCAATCTTACTTTGTCTCTTGGAGATTGTTGAACGCAGCTTGTCTAGGAAGG
1681 GGATGGGACTAGATTCTAAAATTTATTTGGGACCATGGGAATGATAGTTGGGAAGAAAACTATTTGCACACGACAGATTT
1761 CTAGATACTTTTTGCTGCTAGTTTTATGTAATATTTATTGAACATTTTGACAAATATTTATTTTTGTAAGCCTAAAAGTG
1841 ATTCTTTGAAAGTTTAAAGAAACTTGACCAAAAGACAGTACAAAAACACTGGCACTTGAATGTTGAATGTCACCGTATGC
1921 GTGAAATTATATATTTCGGGGTAGTGTGAGCTTTTAATGTTTAAGTCATATTAAACTCTTAAGTCAAATTAAGCAGACCC
2001 GGCGTTGGCAGTGTAGCCATAACTTTCTGATGTTAGTAAAAACAAAATTGGCGACTTGAAATTAAATCATGCCAAGGTTT
2081 TGATACACTTGTCTTAAGATATTAATGAAACACTTCAAAACACTGATGTGAAGTGTCCAGATTCTCAGATGTTTGTTGTG
2161 TGGATTTTGTTTAGTTGTGTGTTTTTTTTTTTTTTTCAGTGAATGTCTGGCACATTGCAATCCTCAAACATGTGGTTATC
2241 TTTGTTGTATTGGCATAATCAGTGACTTGTACATTCAGCAATAGCATTTGAGCAAGTTTTATCAGCAAGCAATATTTTCA
2321 GTTAATAAGGTTTCAAAAATCATGTAAGGATTTAAACTTGCTGAATGTAAAGATTGAACCTCAAGTCACTGTAGCTTTAG
2401 TAATTGCTTATTGTATTAGTTTAGATGCTAGCACTGCATGTGCTGTGCATATTCTGATTTTATTAAAATAAAAAGTTGAA
2481 CTGCACAGTCTCCTTTGTTGTTGTCAATTGTGGTTTATTTTCAGAGGTGTAAATAAAGTGCTCTTGCCTGAAAAATTGTA
2561 AAATGTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acUCUGUCCAAGUACGACGAUa 5'
            |||:|  ||: |||||||| 
Target 5' ctAGATA-CTTTTTGCTGCTAg 3'
1761 - 1781 163.00 -12.60
2
miRNA  3' acUCUGUCCA-AGUACGACGAUa 5'
            :| ||  | |:||| ||||| 
Target 5' gaGGTCATTTGTTATGGTGCTAt 3'
1487 - 1509 128.00 -14.10
3
miRNA  3' acucugucCAAGUACGACGaua 5'
                  ||||| |||||   
Target 5' attactctGTTCAAGCTGCgtt 3'
1062 - 1083 122.00 -11.02
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs761187616 2 dbSNP
rs746863718 3 dbSNP
rs768473702 4 dbSNP
rs776609516 7 dbSNP
rs1204081529 8 dbSNP
rs1348074660 14 dbSNP
rs748100931 21 dbSNP
rs769230915 22 dbSNP
rs1236954563 23 dbSNP
rs772742027 24 dbSNP
rs762467559 29 dbSNP
rs1349058942 32 dbSNP
rs1424227581 40 dbSNP
rs766101073 42 dbSNP
rs972463796 52 dbSNP
rs1169127900 54 dbSNP
rs754064835 56 dbSNP
rs952501851 81 dbSNP
rs1328229472 94 dbSNP
rs985040046 95 dbSNP
rs755187450 96 dbSNP
rs1383054324 102 dbSNP
rs1175831941 107 dbSNP
rs943507901 118 dbSNP
rs1300181162 127 dbSNP
rs1171639212 128 dbSNP
rs962482657 128 dbSNP
rs1242684681 138 dbSNP
rs1388757094 139 dbSNP
rs1191831062 147 dbSNP
rs1039183098 151 dbSNP
rs778745778 152 dbSNP
rs1259101086 161 dbSNP
rs923443460 162 dbSNP
rs933365420 165 dbSNP
rs764539353 166 dbSNP
rs1280101517 175 dbSNP
rs1053633235 177 dbSNP
rs1347355771 192 dbSNP
rs1342056503 197 dbSNP
rs939247104 198 dbSNP
rs1216762770 221 dbSNP
rs992871072 223 dbSNP
rs754205996 230 dbSNP
rs1415649893 241 dbSNP
rs1205924505 243 dbSNP
rs1012020929 244 dbSNP
rs372583916 252 dbSNP
rs1167270173 258 dbSNP
rs1474110199 277 dbSNP
rs1419423041 290 dbSNP
rs1041784596 291 dbSNP
rs1209653125 316 dbSNP
rs1485120176 323 dbSNP
rs905828369 329 dbSNP
rs1208440542 336 dbSNP
rs936191108 373 dbSNP
rs1001408656 374 dbSNP
rs141148280 384 dbSNP
rs1316089939 386 dbSNP
rs1295171475 399 dbSNP
rs1234032480 406 dbSNP
rs1355048552 410 dbSNP
rs1423538754 415 dbSNP
rs1478190157 436 dbSNP
rs1282711044 441 dbSNP
rs1172545984 445 dbSNP
rs1366957515 446 dbSNP
rs1039895211 453 dbSNP
rs1035452036 459 dbSNP
rs998833215 460 dbSNP
rs750738573 461 dbSNP
rs1056357 466 dbSNP
rs993854773 470 dbSNP
rs747950068 479 dbSNP
rs952397173 480 dbSNP
rs1204392224 481 dbSNP
rs1397898932 484 dbSNP
rs1456807873 487 dbSNP
rs1297512247 490 dbSNP
rs1275665342 494 dbSNP
rs1340989779 496 dbSNP
rs984225088 497 dbSNP
rs191078702 502 dbSNP
rs1225710948 503 dbSNP
rs183543802 516 dbSNP
rs1215839614 521 dbSNP
rs1309911956 524 dbSNP
rs1278700251 528 dbSNP
rs772040867 538 dbSNP
rs773176719 540 dbSNP
rs964925651 545 dbSNP
rs975005455 556 dbSNP
rs1460405668 580 dbSNP
rs1033916495 584 dbSNP
rs1160780260 585 dbSNP
rs777617499 587 dbSNP
rs960671126 591 dbSNP
rs1406857452 593 dbSNP
rs1178397139 595 dbSNP
rs1438303306 596 dbSNP
rs1255370095 598 dbSNP
rs747067311 599 dbSNP
rs1194820364 600 dbSNP
rs1468053596 602 dbSNP
rs1245093163 625 dbSNP
rs1218093395 634 dbSNP
rs992462951 642 dbSNP
rs12838867 647 dbSNP
rs1283892673 649 dbSNP
rs1237677834 659 dbSNP
rs923410846 660 dbSNP
rs917260646 666 dbSNP
rs933499622 675 dbSNP
rs945996989 682 dbSNP
rs28364818 693 dbSNP
rs977414349 695 dbSNP
rs1056358 714 dbSNP
rs1364826739 717 dbSNP
rs775642389 718 dbSNP
rs754909334 720 dbSNP
rs189047420 722 dbSNP
rs1161240185 733 dbSNP
rs913342647 741 dbSNP
rs1344233505 744 dbSNP
rs192439219 746 dbSNP
rs1418196022 749 dbSNP
rs770374177 750 dbSNP
rs1174774836 758 dbSNP
rs370210510 759 dbSNP
rs150291427 761 dbSNP
rs937228791 762 dbSNP
rs1188388874 770 dbSNP
rs1262661204 775 dbSNP
rs1056992853 776 dbSNP
rs1486500970 781 dbSNP
rs759161501 784 dbSNP
rs1280820902 809 dbSNP
rs1254214422 811 dbSNP
rs1233343628 812 dbSNP
rs1423294486 814 dbSNP
rs1164511172 818 dbSNP
rs994435964 821 dbSNP
rs1214578256 829 dbSNP
rs770595846 831 dbSNP
rs769385297 833 dbSNP
rs772848431 838 dbSNP
rs934261141 841 dbSNP
rs1416281268 842 dbSNP
rs1051748158 847 dbSNP
rs1313850389 849 dbSNP
rs774766683 869 dbSNP
rs776206800 880 dbSNP
rs1003873359 887 dbSNP
rs1429134732 898 dbSNP
rs1361127563 904 dbSNP
rs1432857432 929 dbSNP
rs1037982553 936 dbSNP
rs1191726249 941 dbSNP
rs1476291761 944 dbSNP
rs1258545901 946 dbSNP
rs1199657920 949 dbSNP
rs898278507 969 dbSNP
rs1252943624 976 dbSNP
rs1001879814 977 dbSNP
rs1300989799 982 dbSNP
rs1306376509 988 dbSNP
rs1275726222 1007 dbSNP
rs184422133 1020 dbSNP
rs1355677530 1029 dbSNP
rs1292364226 1035 dbSNP
rs770503392 1036 dbSNP
rs1395739193 1053 dbSNP
rs1400529378 1053 dbSNP
rs188053707 1055 dbSNP
rs1462971011 1056 dbSNP
rs1400264049 1059 dbSNP
rs1168594661 1063 dbSNP
rs1316727676 1065 dbSNP
rs1418762091 1066 dbSNP
rs758990835 1066 dbSNP
rs1350972903 1076 dbSNP
rs764675036 1082 dbSNP
rs1421784852 1107 dbSNP
rs1252448891 1111 dbSNP
rs966617551 1114 dbSNP
rs1238454753 1118 dbSNP
rs1457248666 1125 dbSNP
rs1256149144 1132 dbSNP
rs977445435 1141 dbSNP
rs1215008588 1143 dbSNP
rs925932716 1154 dbSNP
rs1264435519 1155 dbSNP
rs1285703279 1156 dbSNP
rs1317862541 1158 dbSNP
rs1218617373 1162 dbSNP
rs1271314799 1163 dbSNP
rs1339031638 1164 dbSNP
rs957456713 1176 dbSNP
rs1236216499 1181 dbSNP
rs750904417 1188 dbSNP
rs761286900 1200 dbSNP
rs921448167 1202 dbSNP
rs777316498 1203 dbSNP
rs144966805 1210 dbSNP
rs1159553230 1212 dbSNP
rs1051267844 1214 dbSNP
rs773809766 1215 dbSNP
rs1195434209 1222 dbSNP
rs908822334 1227 dbSNP
rs1266088065 1243 dbSNP
rs1207592176 1249 dbSNP
rs940263723 1258 dbSNP
rs1261007980 1263 dbSNP
rs764737853 1263 dbSNP
rs752012524 1265 dbSNP
rs1402223957 1266 dbSNP
rs1038012318 1269 dbSNP
rs1477104618 1279 dbSNP
rs1443796906 1287 dbSNP
rs762261667 1289 dbSNP
rs1322951376 1291 dbSNP
rs1385223672 1306 dbSNP
rs1387415525 1316 dbSNP
rs1289675436 1322 dbSNP
rs1001964578 1325 dbSNP
rs766527316 1332 dbSNP
rs1378279923 1338 dbSNP
rs5963957 1339 dbSNP
rs1338065735 1344 dbSNP
rs750762642 1348 dbSNP
rs1377052415 1350 dbSNP
rs1445631205 1354 dbSNP
rs755214981 1357 dbSNP
rs896229208 1358 dbSNP
rs765441946 1363 dbSNP
rs1013879402 1364 dbSNP
rs763165535 1369 dbSNP
rs1277123651 1372 dbSNP
rs1284281935 1389 dbSNP
rs1237018292 1390 dbSNP
rs1312074178 1393 dbSNP
rs1346307635 1399 dbSNP
rs966648040 1400 dbSNP
rs1328293693 1404 dbSNP
rs1204422229 1430 dbSNP
rs768052807 1455 dbSNP
rs1399665379 1456 dbSNP
rs1265125033 1457 dbSNP
rs750774419 1459 dbSNP
rs1033012566 1460 dbSNP
rs1435167324 1461 dbSNP
rs1401404636 1462 dbSNP
rs957322741 1467 dbSNP
rs1476080456 1476 dbSNP
rs1198318500 1483 dbSNP
rs1233665628 1488 dbSNP
rs766544623 1515 dbSNP
rs1476621875 1516 dbSNP
rs1471044263 1521 dbSNP
rs1259249406 1523 dbSNP
rs1213454767 1530 dbSNP
rs975429362 1532 dbSNP
rs1278470517 1558 dbSNP
rs1189189198 1562 dbSNP
rs1424396370 1563 dbSNP
rs1341516122 1565 dbSNP
rs1480697833 1565 dbSNP
rs1178458916 1570 dbSNP
rs1218146846 1586 dbSNP
rs780315155 1589 dbSNP
rs1295422189 1590 dbSNP
rs1397559593 1595 dbSNP
rs1464635469 1598 dbSNP
rs921385613 1601 dbSNP
rs1329207075 1603 dbSNP
rs955465927 1603 dbSNP
rs1355852126 1604 dbSNP
rs987403766 1607 dbSNP
rs191556194 1609 dbSNP
rs1273403070 1610 dbSNP
rs1169323377 1611 dbSNP
rs1367309661 1616 dbSNP
rs1419480709 1617 dbSNP
rs908687069 1631 dbSNP
rs1473304674 1634 dbSNP
rs1224718275 1639 dbSNP
rs1285739322 1647 dbSNP
rs940294830 1649 dbSNP
rs755064861 1657 dbSNP
rs1259335126 1663 dbSNP
rs1198019387 1671 dbSNP
rs1273994778 1684 dbSNP
rs1275228800 1694 dbSNP
rs1439722700 1698 dbSNP
rs758067575 1715 dbSNP
rs781079886 1739 dbSNP
rs752699164 1741 dbSNP
rs1219142762 1743 dbSNP
rs1282187881 1744 dbSNP
rs755892218 1746 dbSNP
rs937707942 1747 dbSNP
rs1054796685 1748 dbSNP
rs1421382643 1751 dbSNP
rs1477212035 1752 dbSNP
rs1396065129 1757 dbSNP
rs754009150 1767 dbSNP
rs896250715 1769 dbSNP
rs949152601 1814 dbSNP
rs1161816279 1815 dbSNP
rs1411247556 1815 dbSNP
rs1442006822 1837 dbSNP
rs1167931443 1856 dbSNP
rs1421246939 1875 dbSNP
rs1042259619 1897 dbSNP
rs746905097 1908 dbSNP
rs1456468480 1921 dbSNP
rs1254933570 1926 dbSNP
rs1403287060 1930 dbSNP
rs902325961 1932 dbSNP
rs1288068646 1938 dbSNP
rs1225189619 1939 dbSNP
rs1354161625 1946 dbSNP
rs757222373 1963 dbSNP
rs1032293764 1965 dbSNP
rs1293584333 1979 dbSNP
rs1373154570 1979 dbSNP
rs1435205657 1993 dbSNP
rs780661126 2005 dbSNP
rs1219175866 2014 dbSNP
rs143157550 2023 dbSNP
rs1319885604 2024 dbSNP
rs1421844874 2027 dbSNP
rs1365411949 2032 dbSNP
rs1405933685 2034 dbSNP
rs997275515 2050 dbSNP
rs1028310821 2051 dbSNP
rs745431132 2053 dbSNP
rs1427934263 2054 dbSNP
rs1191839083 2084 dbSNP
rs1488198721 2087 dbSNP
rs749041943 2088 dbSNP
rs184335138 2100 dbSNP
rs986879731 2106 dbSNP
rs1226808944 2111 dbSNP
rs1285010983 2118 dbSNP
rs1270808165 2119 dbSNP
rs1349952545 2129 dbSNP
rs1301978236 2138 dbSNP
rs1218060905 2139 dbSNP
rs1341527904 2140 dbSNP
rs1015716120 2144 dbSNP
rs778479330 2153 dbSNP
rs974204784 2154 dbSNP
rs879175688 2155 dbSNP
rs920217454 2161 dbSNP
rs1224354767 2169 dbSNP
rs1260954973 2173 dbSNP
rs1177439884 2174 dbSNP
rs1423187461 2176 dbSNP
rs1425058200 2176 dbSNP
rs1432613395 2176 dbSNP
rs1478259866 2180 dbSNP
rs1487898852 2180 dbSNP
rs1193769456 2181 dbSNP
rs1275915491 2182 dbSNP
rs1304619885 2182 dbSNP
rs1339439427 2182 dbSNP
rs1491236593 2182 dbSNP
rs201921813 2182 dbSNP
rs745349949 2182 dbSNP
rs745437857 2182 dbSNP
rs1398473587 2183 dbSNP
rs201313897 2183 dbSNP
rs771773583 2184 dbSNP
rs1465956341 2185 dbSNP
rs1471514984 2187 dbSNP
rs1172895256 2196 dbSNP
rs1162351215 2197 dbSNP
rs866735665 2198 dbSNP
rs769484966 2199 dbSNP
rs1165804525 2201 dbSNP
rs188774286 2204 dbSNP
rs1425284066 2214 dbSNP
rs1256634640 2217 dbSNP
rs1359224895 2221 dbSNP
rs1382198766 2230 dbSNP
rs1240020679 2240 dbSNP
rs1198652508 2245 dbSNP
rs762349811 2267 dbSNP
rs181503639 2270 dbSNP
rs1445909834 2272 dbSNP
rs1321986986 2279 dbSNP
rs772277504 2291 dbSNP
rs917563452 2296 dbSNP
rs1333959339 2300 dbSNP
rs1314639250 2303 dbSNP
rs1383729009 2304 dbSNP
rs14554 2313 dbSNP
rs1283670483 2323 dbSNP
rs1369328336 2334 dbSNP
rs949178489 2339 dbSNP
rs1421837483 2340 dbSNP
rs1205703952 2342 dbSNP
rs1042124013 2367 dbSNP
rs902255490 2369 dbSNP
rs773582897 2373 dbSNP
rs1456898193 2376 dbSNP
rs763252865 2381 dbSNP
rs708452 2389 dbSNP
rs1211169031 2390 dbSNP
rs1488597996 2390 dbSNP
rs766604206 2392 dbSNP
rs751771731 2409 dbSNP
rs1244440369 2411 dbSNP
rs1053597919 2412 dbSNP
rs1243394799 2416 dbSNP
rs1312039890 2424 dbSNP
rs1064198 2434 dbSNP
rs900446674 2446 dbSNP
rs996079824 2448 dbSNP
rs3209046 2455 dbSNP
rs1329380276 2464 dbSNP
rs878952279 2467 dbSNP
rs1388665300 2470 dbSNP
rs1391636539 2471 dbSNP
rs1446035893 2473 dbSNP
rs1028759725 2475 dbSNP
rs1456150414 2475 dbSNP
rs1381971534 2481 dbSNP
rs1438979404 2484 dbSNP
rs185737091 2484 dbSNP
rs767643733 2487 dbSNP
rs1200372174 2493 dbSNP
rs1378471289 2493 dbSNP
rs1433273788 2494 dbSNP
rs1266159951 2495 dbSNP
rs752787065 2495 dbSNP
rs1489950380 2497 dbSNP
rs1378910915 2501 dbSNP
rs1288563214 2503 dbSNP
rs891087653 2510 dbSNP
rs1008275330 2511 dbSNP
rs1015666690 2518 dbSNP
rs961438951 2530 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1654.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1654.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000399959.2 | 3UTR | AUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000399959.2 | 3UTR | UUCUAGAUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000399959.2 | 3UTR | AUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000399959.2 | 3UTR | AUUUCUAGAUACUUUUUGCUGCUAGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000399959.2 | 3UTR | AUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000399959.2 | 3UTR | AUUUCUAGAUACUUUUUGCUGCUAGUUUUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000399959.2 | 3UTR | AUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000399959.2 | 3UTR | AUUUCUAGAUACUUUUUGCUGCUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000399959.2 | 3UTR | ACAGAUUUCUAGAUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000399959.2 | 3UTR | AUACUUUUUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
180 hsa-miR-4524a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055251 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT055826 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT060573 CCND1 cyclin D1 2 2
MIRT061013 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT064694 CCND2 cyclin D2 2 4
MIRT075268 SNTB2 syntrophin beta 2 2 4
MIRT079668 NAPG NSF attachment protein gamma 2 12
MIRT081651 CCNE1 cyclin E1 2 4
MIRT082996 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083463 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT085755 RIF1 replication timing regulatory factor 1 2 2
MIRT086022 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087431 ZNRF3 zinc and ring finger 3 2 2
MIRT088786 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT089221 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT093696 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT095090 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT096249 CANX calnexin 2 2
MIRT100215 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100746 VEGFA vascular endothelial growth factor A 2 12
MIRT100904 CD2AP CD2 associated protein 2 2
MIRT102647 UBN2 ubinuclein 2 2 10
MIRT103882 FOXK1 forkhead box K1 2 2
MIRT104246 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106310 ZFHX4 zinc finger homeobox 4 2 6
MIRT107696 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT114943 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117671 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT133799 SKI SKI proto-oncogene 2 2
MIRT140167 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142279 DCTN5 dynactin subunit 5 2 8
MIRT143288 N4BP1 NEDD4 binding protein 1 2 2
MIRT165939 CREBRF CREB3 regulatory factor 2 2
MIRT175251 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT186381 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT191470 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT196480 TAOK1 TAO kinase 1 2 2
MIRT201470 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204615 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204646 MOB4 MOB family member 4, phocein 2 8
MIRT204749 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206031 NUP50 nucleoporin 50 2 6
MIRT211196 FGF2 fibroblast growth factor 2 2 4
MIRT229353 ZNF449 zinc finger protein 449 2 2
MIRT247138 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT249461 ZNF691 zinc finger protein 691 2 4
MIRT256314 CDC42SE2 CDC42 small effector 2 2 2
MIRT258419 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265083 CHEK1 checkpoint kinase 1 2 2
MIRT270561 SETD1B SET domain containing 1B 2 2
MIRT274749 RAB3IP RAB3A interacting protein 2 2
MIRT277515 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT289642 CBX2 chromobox 2 2 2
MIRT301001 MTMR3 myotubularin related protein 3 2 2
MIRT307149 CTDSPL CTD small phosphatase like 2 4
MIRT309021 USP53 ubiquitin specific peptidase 53 2 2
MIRT314100 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT319338 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320619 ZNRF2 zinc and ring finger 2 2 2
MIRT324285 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT446498 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT448437 TLL1 tolloid like 1 2 2
MIRT461537 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463162 ZNF367 zinc finger protein 367 2 10
MIRT463493 ZC3H10 zinc finger CCCH-type containing 10 2 2
MIRT465154 TSC22D2 TSC22 domain family member 2 2 2
MIRT466418 TFAP2A transcription factor AP-2 alpha 2 8
MIRT468278 SFT2D2 SFT2 domain containing 2 2 2
MIRT469399 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471941 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT473688 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT479618 CDC25A cell division cycle 25A 2 2
MIRT482098 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483995 ATAD5 ATPase family, AAA domain containing 5 2 12
MIRT485205 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT498763 C3orf38 chromosome 3 open reading frame 38 2 8
MIRT498961 ORC4 origin recognition complex subunit 4 2 8
MIRT499440 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500080 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500305 ZNF622 zinc finger protein 622 2 8
MIRT500410 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500789 TLK1 tousled like kinase 1 2 6
MIRT500930 SRPR SRP receptor alpha subunit 2 6
MIRT500943 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501068 SMAD7 SMAD family member 7 2 8
MIRT501711 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT502627 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502910 CDCA4 cell division cycle associated 4 2 8
MIRT502935 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504531 ZNF620 zinc finger protein 620 2 6
MIRT505106 YTHDC1 YTH domain containing 1 2 6
MIRT505337 TMEM245 transmembrane protein 245 2 6
MIRT505383 TMEM100 transmembrane protein 100 2 2
MIRT505678 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506157 PLAG1 PLAG1 zinc finger 2 8
MIRT506183 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506475 MYO5A myosin VA 2 6
MIRT506826 KIF23 kinesin family member 23 2 6
MIRT507160 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT507511 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT507845 CCNE2 cyclin E2 2 6
MIRT510403 ZNF507 zinc finger protein 507 2 2
MIRT518078 TRIM35 tripartite motif containing 35 2 2
MIRT518982 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521045 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521190 SBNO1 strawberry notch homolog 1 2 6
MIRT522088 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT524846 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT527787 TMEM44 transmembrane protein 44 2 4
MIRT537803 EFNB2 ephrin B2 2 4
MIRT540830 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541140 PISD phosphatidylserine decarboxylase 2 2
MIRT541419 CBX4 chromobox 4 2 2
MIRT543517 PRSS21 protease, serine 21 2 2
MIRT543824 GSG1 germ cell associated 1 2 2
MIRT544959 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545179 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545335 CCDC83 coiled-coil domain containing 83 2 2
MIRT545518 RSL24D1 ribosomal L24 domain containing 1 2 2
MIRT545670 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545931 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546102 USP48 ubiquitin specific peptidase 48 2 4
MIRT546598 SALL1 spalt like transcription factor 1 2 4
MIRT546626 RTN4 reticulon 4 2 2
MIRT547651 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547987 HCFC2 host cell factor C2 2 4
MIRT548717 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548931 CDK17 cyclin dependent kinase 17 2 2
MIRT549067 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549266 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT550460 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550806 FAM229B family with sequence similarity 229 member B 2 2
MIRT552024 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552334 ZNF704 zinc finger protein 704 2 2
MIRT552732 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553795 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554694 RNF149 ring finger protein 149 2 2
MIRT555133 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555264 PRDM4 PR/SET domain 4 2 2
MIRT556848 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557474 GPR27 G protein-coupled receptor 27 2 4
MIRT558018 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558498 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558579 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558610 COX6B1 cytochrome c oxidase subunit 6B1 2 4
MIRT558650 CNKSR3 CNKSR family member 3 2 2
MIRT558986 CA8 carbonic anhydrase 8 2 2
MIRT559141 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559327 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT562021 LANCL1 LanC like 1 2 2
MIRT562869 KIAA1456 KIAA1456 2 2
MIRT563074 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563496 DLGAP3 DLG associated protein 3 2 2
MIRT563890 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564311 CCNT1 cyclin T1 2 2
MIRT564942 XKR7 XK related 7 2 2
MIRT564979 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565423 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566824 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571961 KIF5B kinesin family member 5B 2 2
MIRT575877 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT576523 Txlna taxilin alpha 2 2
MIRT614693 TRAK1 trafficking kinesin protein 1 2 2
MIRT616065 ZC3H14 zinc finger CCCH-type containing 14 2 2
MIRT618838 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT624626 ATXN2 ataxin 2 2 2
MIRT624652 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT640314 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT659248 CUL3 cullin 3 2 2
MIRT680972 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682261 RS1 retinoschisin 1 2 2
MIRT682505 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693904 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT699214 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT699373 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699451 SLC16A9 solute carrier family 16 member 9 2 2
MIRT701230 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702849 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT706163 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT718990 UTP15 UTP15, small subunit processome component 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4524a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4524a-5p Cetuximab resistant tissue (colorectal carcinoma)

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