miRTarBase - #MIRT502882


—
pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol CDK4   
Synonyms CMM3, PSK-J3
Description cyclin dependent kinase 4
Transcript NM_000075   
Expression
Putative miRNA Targets on CDK4
3'UTR of CDK4
(miRNA target sites are highlighted)		 
>CDK4|NM_000075|3'UTR
   1 GCAATGGAGTGGCTGCCATGGAAGGAAGAAAAGCTGCCATTTCCCTTCTGGACACTGAGAGGGCAATCTTTGCCTTTATC
  81 TCTGAGGCTATGGAGGGTCCTCCTCCATCTTTCTACAGAGATTACTTTGCTGCCTTAATGACATTCCCCTCCCACCTCTC
 161 CTTTTGAGGCTTCTCCTTCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCTCTTGTCCCTTTCCCTACCTTTATA
 241 TTTGGGGTCCTTTTTTATACAGGAAAAACAAAACAAAGAAATAATGGTCTTTTTTTTTTTTTTAATGTTTCTTCCTCTGT
 321 TTGGCTTTGCCATTGTGCGATTTGGAAAAACCACTTGGAAGAAGGGACTTTCCTGCAAAACCTTAAAGACTGGTTAAATT
 401 ACAGGGCCTAGGAAGTCAGTGGAGCCCCTTGACTGACAAAGCTTAGAAAGGAACTGAAATTGCTTCTTTGAATATGGATT
 481 TTAGGCGGGGCGTGGTGGCTCACGCCTATAATCCCAGCACGTTGGGAGGCCAACGCGGGTGGATCACCTGAGGTCAGGAG
 561 TTCGAGACCAGCCTGACTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAATTAGTCAGGCGTGGTGGTGCACACC
 641 TGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCGCTTGAACCCGGGAGGCAGAGGTTGCGGTGAGCCGAGATCA
 721 TGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTGTCAAAAAAAAAAAAAGAATATAGATTTTTAAATGGCAA
 801 AAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agugucAACGGUCG-ACUCUAAu 5'
                |||||| : || |||| 
Target 5' ttggctTTGCCATTGTGCGATTt 3'
 321 - 343 128.00 -8.60
2 
miRNA  3' agUGUCAAC--GGUCGACUCUAau 5'
            :|:| ||  :|| |||||:|  
Target 5' acGCGGGTGGATCACCTGAGGTca 3'
 533 - 556 126.00 -16.90
3 
miRNA  3' agugucAACGGUCGACUCUAAu 5'
                || |:| | |||||| 
Target 5' tccatcTTTCTA-CAGAGATTa 3'
 104 - 124 123.00 -7.91
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
188065 5 ClinVar
384740 12 ClinVar
309977 210 ClinVar
309976 246 ClinVar
884129 271 ClinVar
309974 304 ClinVar
309975 304 ClinVar
309973 319 ClinVar
884128 333 ClinVar
309972 370 ClinVar
882420 424 ClinVar
309971 437 ClinVar
309970 479 ClinVar
309969 491 ClinVar
309968 521 ClinVar
309967 689 ClinVar
309966 690 ClinVar
309965 706 ClinVar
882173 734 ClinVar
882172 751 ClinVar
309964 764 ClinVar
309963 778 ClinVar
COSN31597858 16 COSMIC
COSN30504077 21 COSMIC
COSN30514110 30 COSMIC
COSN30481994 43 COSMIC
COSN27000280 56 COSMIC
COSN30140215 59 COSMIC
COSN13410063 63 COSMIC
COSN30514804 74 COSMIC
COSN30698275 100 COSMIC
COSN30155601 166 COSMIC
COSN30511504 171 COSMIC
COSN31542388 278 COSMIC
COSN26637072 330 COSMIC
COSN31565159 380 COSMIC
COSN32010263 489 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs786204045 5 dbSNP
rs1196923268 9 dbSNP
rs770044583 12 dbSNP
rs1191724475 14 dbSNP
rs748223579 16 dbSNP
rs1225004491 17 dbSNP
rs373442519 18 dbSNP
rs1172367214 19 dbSNP
rs754876640 23 dbSNP
rs1315410858 28 dbSNP
rs746950724 31 dbSNP
rs779845928 33 dbSNP
rs1309022049 35 dbSNP
rs1017192884 40 dbSNP
rs2069510 44 dbSNP
rs1460605718 48 dbSNP
rs758102242 50 dbSNP
rs1323224963 57 dbSNP
rs1396066642 66 dbSNP
rs982854686 72 dbSNP
rs1294675919 93 dbSNP
rs951446771 96 dbSNP
rs1221509321 107 dbSNP
rs1029790530 108 dbSNP
rs1395127864 115 dbSNP
rs1489692361 125 dbSNP
rs1293552957 128 dbSNP
rs573865135 133 dbSNP
rs1280507408 134 dbSNP
rs1042890478 137 dbSNP
rs1246031626 150 dbSNP
rs555555387 157 dbSNP
rs899861787 158 dbSNP
rs1271298523 181 dbSNP
rs1352426983 188 dbSNP
rs1323632337 191 dbSNP
rs187207546 193 dbSNP
rs1241728307 197 dbSNP
rs1000870693 203 dbSNP
rs1336872901 209 dbSNP
rs2069511 210 dbSNP
rs563404067 214 dbSNP
rs890445351 221 dbSNP
rs1367654009 224 dbSNP
rs1304056687 231 dbSNP
rs1415298343 236 dbSNP
rs763088789 246 dbSNP
rs1166097174 247 dbSNP
rs775148859 253 dbSNP
rs1429246268 257 dbSNP
rs1300396808 270 dbSNP
rs1051806760 271 dbSNP
rs3180722 274 dbSNP
rs1160378757 276 dbSNP
rs3179899 278 dbSNP
rs929538327 282 dbSNP
rs1471098856 286 dbSNP
rs1291708445 290 dbSNP
rs1381424006 291 dbSNP
rs945105324 292 dbSNP
rs1198394660 294 dbSNP
rs1283666175 299 dbSNP
rs3180723 303 dbSNP
rs1238908150 304 dbSNP
rs1314984297 304 dbSNP
rs372480061 304 dbSNP
rs59185470 304 dbSNP
rs78419156 304 dbSNP
rs886049711 304 dbSNP
rs886049712 304 dbSNP
rs1479356346 305 dbSNP
rs1472931647 306 dbSNP
rs1270587986 307 dbSNP
rs917883102 311 dbSNP
rs1446078911 314 dbSNP
rs1418358557 315 dbSNP
rs1161024667 319 dbSNP
rs775370483 319 dbSNP
rs1206405976 324 dbSNP
rs1434560470 324 dbSNP
rs1332419296 332 dbSNP
rs199606572 333 dbSNP
rs942188819 338 dbSNP
rs1274823483 339 dbSNP
rs1371301661 351 dbSNP
rs1475994409 354 dbSNP
rs1242194964 358 dbSNP
rs1309932398 362 dbSNP
rs1222065344 364 dbSNP
rs59273640 369 dbSNP
rs3473 370 dbSNP
rs990566844 372 dbSNP
rs1442604082 375 dbSNP
rs1056173330 381 dbSNP
rs1203405595 390 dbSNP
rs1230656395 394 dbSNP
rs939004598 397 dbSNP
rs926312287 424 dbSNP
rs1441045730