pre-miRNA Information
pre-miRNA hsa-mir-4282   
Genomic Coordinates chr6: 72967687 - 72967753
Description Homo sapiens miR-4282 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4282
Sequence 40| UAAAAUUUGCAUCCAGGA |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN32074657 13 COSMIC
COSN6331413 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1195771339 5 dbSNP
rs755058572 6 dbSNP
rs1245753664 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CDC37L1   
Synonyms CDC37B, HARC
Description cell division cycle 37 like 1
Transcript NM_017913   
Expression
Putative miRNA Targets on CDC37L1
3'UTR of CDC37L1
(miRNA target sites are highlighted)
>CDC37L1|NM_017913|3'UTR
   1 TTTGGTTAAGACTGCTGAGGCCAAGTGCTATTTTGTTACAAGAAAGGAAGAACTTGGCTATTTTCTTGACACTTTTATGG
  81 GTGCTGCACTTTATTTTTGTTCGGTTTTTGATGGGAGGGAAAGAGTACTGAAATGTTTTGTAAATTTTTTTTAATGTGCT
 161 GCTAGGTTTTTTGTTTTGTTTTGTTCTGAAGAGAAGAGTGGTACCATATGTTGCAGGAAGTCAAACTGGACTTTTTGTGG
 241 CTACTAAATTTGCTTTTAATCTTATTGTTCTCAATTTTGGAATCAAGTATGAAAATCTGCACAAATGCAATGTTTACAAG
 321 AACTGGTTGATTCTGGGAGGCATCTGCTACAGTCTCTTTTTATATGGATATGTACATGTCCTATTCTACAAAAATGATTA
 401 AAGATAAAAACATACTTGTATCCCACTGCTACTTTAGCTGTCAAATTTGGTGTTTCATCACATTAAAAGCAATAAATCAG
 481 TAGTTGGTAATGTACTTTACTAAATAAGTTGGGGGGTACAATTTTTAAAAGTCTTAACTCTTAAATACTTGACTTTCGGC
 561 ACCATCAGTTAAATCCTTGACTATAATACAAATTTGATATATACATTACATTTACCCTCAAATTATTCTCAAAACTATAT
 641 TCCTTAGAATTTGATTTTACCCTGCTGACTTTAAGAGTTATAATAATATCAAATGTGATGAGCTAATATAGATTTTCTTT
 721 TTAAATAAGAATAACTTCAAGCTCACTCTTTCTTAACATAGTCTGGGATCTCTCAGGGAGTAAGTTTTAAAAGAATACTA
 801 ATGGCTTGTAAGAACAAACAGGAATAATAATCTGATTTTTAAATTTGTAGTTATTTTACTCATGTTGCCTTTTAATTTTT
 881 GTTATTTTGGTTTATTTTTTGATGTAGCCTTTTAAAAAAGGAGTCTTAAAAATGATTTTTTTTTTAAAGGCAAGAGAAAT
 961 CTTGTAGTGCTAACTGCCTTGAGCTGCCAATTACCTATTTCTGAGAATTTGGTGACTCTTATTGGTAATGATGGCATTTA
1041 CAACATTTGGCATTTCCCCTTTTTCAGCTCAGTTACCATAGAATACTTCCAAGCTTTACTACTTCCTCTGTAAGTCATTT
1121 CAGTTATGCCAGGATATTTGATGATTTTGTTTATGTAGAATTAGGTAACAAAGCCAATTATGCTATCCTTATTATTGAAG
1201 GATTAATCTTATGACTTAACATAAGCTTTGGTTATATTTGGGTGTAGTCTTTGGCTAAGTACCCATTAAGGCTAGTAGCA
1281 AACACTTGGAAGGTGGCTAACTGGGACTGGGAATACGTGTCTCAACTTGAGAAACCAAATAGTGCGAAGGGACTCAGGGT
1361 GGCCAGACCTGTGACCTTGGCCTCATTTGTATCTTGTTTTCGCTGAGGTGATCAGACACTTAGTACCCTAGAAATGGACT
1441 GGAATTATTGAATCTTCTTCTGTAACATCACAATCTTCCTGGTTTTCAGAATAAACGTTTTTGTGCTTTTGATATAAATA
1521 TATACTCTATAATAAAATGTTTGACTAATTTATATAGTAGTGTTTGTCAGCCTGTACTTTTTTTTTTTTTAAACCCATGA
1601 CCTAGTCGTAGACATTTTTTTCTTTTTGTTCTGTTCTGAAGCAAGCTCTTATTTTTCCCTTTCTACCAAATTGAGAGAAT
1681 GGGCAGACACAGGAGCCATATTCCTAGTTTCACAGAAATGTTACTTGAATTATTATTTTCCCTTCTTTCCCAGGATTTGC
1761 CTGTAAGCATTCAAATTGTTTTGAATTTCATTTTGCCTTCTCTAAGTTAGAGGTATTTAATGACTGAAGACTGGCAGGAG
1841 AGAAAGTATCAACAAACTGAGTAAACTATTCTTGAGGGGCACTGAAAAGATGTTCTTTGAAACTTGATTTATATATTTTT
1921 ACTTGCAAAAGAATATACTGTGTTTTGAGTATGAAAGTGTGATTGGGTCTGTTGTGGGAACCACTGACTGATGCCATAAT
2001 TTGCACTTAAAGGCTATAAATTACATAGTTAGCCGTACTTTAGTACTAGAAACAGTAAATTGACATCCTTGAACTAATTC
2081 CTACCTTTTTTTTGTTTCTGAAGAAATAAAGAGTATATTAAGCAAAGGGATAATTTATATTTCAGGTTGGACAATTTACC
2161 CTAAACAAATTAAACCATGGAAAGTGCAAACACATGAATGAAACATTTTTTTACATCAAAGTATCATCAAAGATTCTTGT
2241 TTCATTTGATAAAATTAATATTTGAATAAAAAAATTTTTAAATCAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aggaccuACGUUUAAAAu 5'
                 ||:||||||| 
Target 5' aatgtttTGTAAATTTTt 3'
132 - 149 151.00 -6.00
2
miRNA  3' agGACCUACGUUUAAAAu 5'
            | ||: |:||:|||| 
Target 5' ctCAGGGAGTAAGTTTTa 3'
772 - 789 140.00 -12.90
3
miRNA  3' aggaCCUACGUUUAAAAu 5'
              ||:| ||| |||| 
Target 5' tgggGGGTACAATTTTTa 3'
510 - 527 126.00 -7.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30478685 18 COSMIC
COSN24383646 36 COSMIC
COSN31605891 43 COSMIC
COSN30101167 83 COSMIC
COSN14690237 103 COSMIC
COSN31605661 124 COSMIC
COSN14732220 255 COSMIC
COSN31543400 484 COSMIC
COSN5122503 486 COSMIC
COSN17246367 602 COSMIC
COSN6391329 680 COSMIC
COSN14932560 850 COSMIC
COSN28350504 947 COSMIC
COSN2324193 999 COSMIC
COSN14715903 1403 COSMIC
COSN27372260 1591 COSMIC
COSN29042899 1591 COSMIC
COSN22314754 1734 COSMIC
COSN14857540 1875 COSMIC
COSN6391330 1964 COSMIC
COSN29573937 2039 COSMIC
rs5896088 937 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs146797512 2 dbSNP
rs772600145 3 dbSNP
rs999274097 4 dbSNP
rs1444411133 5 dbSNP
rs1030707427 21 dbSNP
rs777016331 22 dbSNP
rs757190322 26 dbSNP
rs780291470 27 dbSNP
rs773549976 31 dbSNP
rs761267269 32 dbSNP
rs771362931 34 dbSNP
rs777140681 36 dbSNP
rs893463323 37 dbSNP
rs759258159 40 dbSNP
rs765043024 43 dbSNP
rs1416500801 48 dbSNP
rs752230524 50 dbSNP
rs1311132117 51 dbSNP
rs759269327 69 dbSNP
rs907281357 70 dbSNP
rs139119662 83 dbSNP
rs1301026545 88 dbSNP
rs1329142371 94 dbSNP
rs2181341 103 dbSNP
rs1053043632 109 dbSNP
rs1331666557 112 dbSNP
rs893095266 123 dbSNP
rs1286681105 124 dbSNP
rs969639406 126 dbSNP
rs572973137 130 dbSNP
rs1308209386 134 dbSNP
rs554440739 135 dbSNP
rs1393625881 136 dbSNP
rs1174728602 137 dbSNP
rs1488488054 139 dbSNP
rs561935368 140 dbSNP
rs1363798161 141 dbSNP
rs1180296600 143 dbSNP
rs1484046210 145 dbSNP
rs1190275383 152 dbSNP
rs1252664352 156 dbSNP
rs191748795 157 dbSNP
rs1038920924 161 dbSNP
rs536162441 169 dbSNP
rs972113176 169 dbSNP
rs900350219 173 dbSNP
rs114979068 177 dbSNP
rs775962369 184 dbSNP
rs184596799 187 dbSNP
rs1030115022 189 dbSNP
rs1415339216 191 dbSNP
rs944874162 197 dbSNP
rs1473879691 202 dbSNP
rs1412764277 205 dbSNP
rs1040587579 207 dbSNP
rs1474346161 221 dbSNP
rs763517846 225 dbSNP
rs1211102316 238 dbSNP
rs1165617397 241 dbSNP
rs1193639135 245 dbSNP
rs3174298 255 dbSNP
rs1283333579 257 dbSNP
rs531622067 265 dbSNP
rs1004590339 266 dbSNP
rs1268194988 271 dbSNP
rs545358882 273 dbSNP
rs1292036141 275 dbSNP
rs1398848427 280 dbSNP
rs1448336683 283 dbSNP
rs1326177966 288 dbSNP
rs1052165866 296 dbSNP
rs893494467 297 dbSNP
rs1309709450 300 dbSNP
rs1390102561 302 dbSNP
rs1164838493 303 dbSNP
rs1459885490 310 dbSNP
rs755740888 311 dbSNP
rs1416080146 312 dbSNP
rs1182625806 317 dbSNP
rs1475232335 321 dbSNP
rs765975391 328 dbSNP
rs565074108 341 dbSNP
rs1023981270 353 dbSNP
rs1213008335 367 dbSNP
rs565112709 370 dbSNP
rs386731955 372 dbSNP
rs188682303 373 dbSNP
rs192852130 374 dbSNP
rs1220120458 385 dbSNP
rs1034847919 387 dbSNP
rs1437638722 389 dbSNP
rs1366391310 398 dbSNP
rs961836517 413 dbSNP
rs1263358473 419 dbSNP
rs970656375 420 dbSNP
rs753578502 427 dbSNP
rs1481391086 429 dbSNP
rs1199741627 434 dbSNP
rs775201034 435 dbSNP
rs372254206 438 dbSNP
rs754718438 446 dbSNP
rs74660776 451 dbSNP
rs986111213 456 dbSNP
rs532213892 457 dbSNP
rs1438160096 460 dbSNP
rs910542348 461 dbSNP
rs1451038006 463 dbSNP
rs1248440540 469 dbSNP
rs1053097384 471 dbSNP
rs1415109298 473 dbSNP
rs549477192 479 dbSNP
rs376830552 481 dbSNP
rs1221745742 487 dbSNP
rs914568731 501 dbSNP
rs1423345238 503 dbSNP
rs1271966896 509 dbSNP
rs1436724059 509 dbSNP
rs1230186640 511 dbSNP
rs1343268810 512 dbSNP
rs1303180694 514 dbSNP
rs947384710 522 dbSNP
rs945011765 527 dbSNP
rs1375043518 539 dbSNP
rs976319737 558 dbSNP
rs1039386352 559 dbSNP
rs1310037301 564 dbSNP
rs900403377 568 dbSNP
rs997384590 569 dbSNP
rs1051595376 573 dbSNP
rs886234974 577 dbSNP
rs1004642883 584 dbSNP
rs924797207 587 dbSNP
rs185756287 597 dbSNP
rs934792127 606 dbSNP
rs1052195596 610 dbSNP
rs189256250 611 dbSNP
rs1479996873 612 dbSNP
rs1249023000 615 dbSNP
rs893521831 618 dbSNP
rs946376423 634 dbSNP
rs1044774924 637 dbSNP
rs1444256439 640 dbSNP
rs904846960 643 dbSNP
rs1003488922 644 dbSNP
rs1314315066 661 dbSNP
rs1015986883 662 dbSNP
rs1223740028 665 dbSNP
rs963394909 666 dbSNP
rs1379772099 670 dbSNP
rs1410647809 670 dbSNP
rs1301318992 673 dbSNP
rs1375134781 673 dbSNP
rs1464303167 674 dbSNP
rs1360704504 680 dbSNP
rs552180582 687 dbSNP
rs897678679 693 dbSNP
rs1308955656 696 dbSNP
rs993259267 698 dbSNP
rs1023669076 707 dbSNP
rs1027700057 710 dbSNP
rs1256288994 724 dbSNP
rs1179771959 727 dbSNP
rs1484415954 728 dbSNP
rs952203526 735 dbSNP
rs1215671145 746 dbSNP
rs34269993 747 dbSNP
rs71497546 747 dbSNP
rs1270084797 757 dbSNP
rs1354913436 759 dbSNP
rs970278829 764 dbSNP
rs1398035197 768 dbSNP
rs1205919924 773 dbSNP
rs558829354 779 dbSNP
rs1483192209 782 dbSNP
rs1456627617 794 dbSNP
rs565523819 804 dbSNP
rs1161291888 809 dbSNP
rs966422956 817 dbSNP
rs981617668 821 dbSNP
rs1184913006 823 dbSNP
rs1263962481 823 dbSNP
rs534549542 830 dbSNP
rs924828372 831 dbSNP
rs1463824142 835 dbSNP
rs956199857 835 dbSNP
rs956177681 837 dbSNP
rs1334199661 845 dbSNP
rs1263797649 848 dbSNP
rs2026916 850 dbSNP
rs1313156788 851 dbSNP
rs1177924752 860 dbSNP
rs180937132 866 dbSNP
rs1362788571 867 dbSNP
rs1045200187 869 dbSNP
rs926330447 874 dbSNP
rs1389351803 876 dbSNP
rs1161004985 885 dbSNP
rs947403130 890 dbSNP
rs938993482 891 dbSNP
rs1039026475 896 dbSNP
rs1459113659 902 dbSNP
rs1056319080 909 dbSNP
rs751039476 914 dbSNP
rs751153472 914 dbSNP
rs1400040422 915 dbSNP
rs1392451051 917 dbSNP
rs921882950 920 dbSNP
rs1451586694 921 dbSNP
rs933227916 922 dbSNP
rs1315661209 926 dbSNP
rs1007667217 928 dbSNP
rs1018080562 931 dbSNP
rs1250914381 936 dbSNP
rs1299603281 936 dbSNP
rs397894830 936 dbSNP
rs5896088 936 dbSNP
rs966084357 936 dbSNP
rs1031930590 946 dbSNP
rs1279778983 951 dbSNP
rs574288812 957 dbSNP
rs761692465 957 dbSNP
rs1387942930 962 dbSNP
rs1390850702 965 dbSNP
rs72695843 967 dbSNP
rs556714251 973 dbSNP
rs940482979 975 dbSNP
rs1244294434 976 dbSNP
rs546312708 982 dbSNP
rs1477985786 983 dbSNP
rs1376361815 990 dbSNP
rs576509434 991 dbSNP
rs545155737 998 dbSNP
rs898904153 1003 dbSNP
rs1012361869 1015 dbSNP
rs1203249834 1016 dbSNP
rs970610623 1022 dbSNP
rs565317973 1023 dbSNP
rs1193009802 1027 dbSNP
rs1344045056 1028 dbSNP
rs572343858 1042 dbSNP
rs926334256 1048 dbSNP
rs1023299757 1049 dbSNP
rs1481537130 1051 dbSNP
rs1331147916 1056 dbSNP
rs540928226 1066 dbSNP
rs1407600721 1067 dbSNP
rs1372093598 1071 dbSNP
rs906173105 1071 dbSNP
rs1402157533 1072 dbSNP
rs1425631499 1074 dbSNP
rs1400545778 1077 dbSNP
rs560807071 1080 dbSNP
rs1035879078 1083 dbSNP
rs1180182975 1087 dbSNP
rs1473695164 1090 dbSNP
rs1049433131 1099 dbSNP
rs369735812 1100 dbSNP
rs1187129774 1101 dbSNP
rs956230169 1103 dbSNP
rs529856892 1118 dbSNP
rs1276289078 1119 dbSNP
rs758425018 1122 dbSNP
rs575160035 1124 dbSNP
rs943167287 1137 dbSNP
rs1039126443 1144 dbSNP
rs755988434 1148 dbSNP
rs1333079159 1150 dbSNP
rs73641803 1166 dbSNP
rs1351813608 1168 dbSNP
rs563320094 1174 dbSNP
rs1438186355 1178 dbSNP
rs1275007458 1185 dbSNP
rs1446877992 1186 dbSNP
rs1339046410 1187 dbSNP
rs1367382110 1201 dbSNP
rs968828581 1213 dbSNP
rs1031710121 1214 dbSNP
rs1388637957 1214 dbSNP
rs532270418 1218 dbSNP
rs1412830188 1223 dbSNP
rs919833263 1228 dbSNP
rs551977077 1231 dbSNP
rs1162855787 1237 dbSNP
rs34605926 1240 dbSNP
rs397894525 1240 dbSNP
rs200892339 1241 dbSNP
rs1022267801 1242 dbSNP
rs565717812 1246 dbSNP
rs1461600431 1248 dbSNP
rs1247405095 1250 dbSNP
rs929906427 1254 dbSNP
rs1330654300 1255 dbSNP
rs1284298474 1256 dbSNP
rs1227405525 1257 dbSNP
rs530651902 1265 dbSNP
rs970261278 1269 dbSNP
rs1286322858 1272 dbSNP
rs777951860 1282 dbSNP
rs1453915457 1283 dbSNP
rs534552489 1293 dbSNP
rs1319185531 1302 dbSNP
rs1490845514 1309 dbSNP
rs183603164 1312 dbSNP
rs1322909714 1317 dbSNP
rs143081497 1318 dbSNP
rs1477589421 1322 dbSNP
rs944073776 1324 dbSNP
rs1382143334 1326 dbSNP
rs1445068075 1328 dbSNP
rs1039796472 1330 dbSNP
rs1157589156 1339 dbSNP
rs899958207 1340 dbSNP
rs1466158922 1342 dbSNP
rs991856719 1342 dbSNP
rs1242204463 1345 dbSNP
rs1406561036 1346 dbSNP
rs1323831471 1347 dbSNP
rs1291647469 1354 dbSNP
rs367769797 1356 dbSNP
rs1434809257 1360 dbSNP
rs947574781 1367 dbSNP
rs771084248 1376 dbSNP
rs1363191859 1383 dbSNP
rs569494478 1385 dbSNP
rs776693963 1386 dbSNP
rs536923973 1392 dbSNP
rs1434476559 1400 dbSNP
rs770138959 1402 dbSNP
rs14731 1403 dbSNP
rs7029799 1408 dbSNP
rs539167659 1409 dbSNP
rs558733501 1410 dbSNP
rs1451256904 1411 dbSNP
rs901667183 1414 dbSNP
rs1190535046 1418 dbSNP
rs933417929 1420 dbSNP
rs1450053389 1428 dbSNP
rs1222803475 1429 dbSNP
rs1272942699 1432 dbSNP
rs1482492846 1432 dbSNP
rs1219189231 1436 dbSNP
rs1207823644 1437 dbSNP
rs1308433300 1440 dbSNP
rs78211566 1449 dbSNP
rs1023381417 1451 dbSNP
rs1301245801 1452 dbSNP
rs1217945866 1453 dbSNP
rs1369858645 1474 dbSNP
rs188693962 1477 dbSNP
rs1409455748 1478 dbSNP
rs969577245 1479 dbSNP
rs1457993090 1489 dbSNP
rs973919480 1490 dbSNP
rs748275302 1497 dbSNP
rs1378352680 1498 dbSNP
rs1354871444 1501 dbSNP
rs1473521253 1507 dbSNP
rs753670885 1509 dbSNP
rs1053174456 1512 dbSNP
rs1026842847 1515 dbSNP
rs1199428800 1516 dbSNP
rs891818465 1518 dbSNP
rs1249241951 1523 dbSNP
rs1011959071 1530 dbSNP
rs1021881811 1537 dbSNP
rs12340664 1539 dbSNP
rs1255729252 1555 dbSNP
rs147040693 1557 dbSNP
rs1263833060 1558 dbSNP
rs1227932801 1560 dbSNP
rs574422737 1561 dbSNP
rs944053700 1562 dbSNP
rs117770547 1569 dbSNP
rs1342764377 1570 dbSNP
rs1373818023 1571 dbSNP
rs1245665543 1575 dbSNP
rs1025991451 1578 dbSNP
rs1177054978 1578 dbSNP
rs200175335 1578 dbSNP
rs74330499 1578 dbSNP
rs796114079 1578 dbSNP
rs921348136 1579 dbSNP
rs950394633 1591 dbSNP
rs984822692 1593 dbSNP
rs1160879630 1596 dbSNP
rs1419250826 1597 dbSNP
rs1255918917 1606 dbSNP
rs1180413179 1608 dbSNP
rs1484438850 1609 dbSNP
rs1208623724 1615 dbSNP
rs908875350 1615 dbSNP
rs1327207799 1620 dbSNP
rs201329351 1623 dbSNP
rs747361842 1623 dbSNP
rs1321281096 1624 dbSNP
rs1318359033 1629 dbSNP
rs552594935 1632 dbSNP
rs1248379888 1634 dbSNP
rs1444057756 1639 dbSNP
rs943314445 1646 dbSNP
rs1187705097 1647 dbSNP
rs1434228483 1657 dbSNP
rs947483770 1660 dbSNP
rs1385831534 1665 dbSNP
rs974672744 1667 dbSNP
rs1453998678 1684 dbSNP
rs1367596164 1686 dbSNP
rs1162241171 1708 dbSNP
rs1043208935 1715 dbSNP
rs534154211 1727 dbSNP
rs1386214378 1728 dbSNP
rs755307405 1729 dbSNP
rs554342582 1731 dbSNP
rs934881177 1734 dbSNP
rs45506895 1741 dbSNP
rs1205864018 1742 dbSNP
rs913281649 1744 dbSNP
rs765973888 1746 dbSNP
rs1263952285 1750 dbSNP
rs947493991 1755 dbSNP
rs1361368914 1783 dbSNP
rs296820 1785 dbSNP
rs545887990 1786 dbSNP
rs538505392 1791 dbSNP
rs1405066689 1809 dbSNP
rs1397110579 1814 dbSNP
rs1382352331 1818 dbSNP
rs1389357248 1832 dbSNP
rs905851519 1833 dbSNP
rs1366600861 1835 dbSNP
rs1168283407 1836 dbSNP
rs1334020794 1839 dbSNP
rs1057292934 1844 dbSNP
rs559145756 1845 dbSNP
rs896002380 1847 dbSNP
rs1401867942 1850 dbSNP
rs114657328 1851 dbSNP
rs904922664 1855 dbSNP
rs1340083884 1861 dbSNP
rs1490558054 1866 dbSNP
rs1217851656 1867 dbSNP
rs995682547 1879 dbSNP
rs1339785939 1893 dbSNP
rs1249386070 1896 dbSNP
rs554491689 1904 dbSNP
rs950561443 1904 dbSNP
rs138255709 1907 dbSNP
rs951199956 1912 dbSNP
rs1004091758 1915 dbSNP
rs1019538347 1917 dbSNP
rs975082960 1919 dbSNP
rs965706971 1923 dbSNP
rs1345827179 1927 dbSNP
rs1307015337 1937 dbSNP
rs1428277019 1938 dbSNP
rs1399045786 1939 dbSNP
rs867378033 1941 dbSNP
rs1484418787 1943 dbSNP
rs74725803 1946 dbSNP
rs988683717 1954 dbSNP
rs1480801339 1958 dbSNP
rs913064069 1960 dbSNP
rs759234361 1962 dbSNP
rs1192023910 1963 dbSNP
rs1435904555 1966 dbSNP
rs1168439860 1970 dbSNP
rs947490061 1970 dbSNP
rs1379748218 1973 dbSNP
rs968804202 1976 dbSNP
rs1043128757 1977 dbSNP
rs1224882920 1981 dbSNP
rs978824193 1982 dbSNP
rs1172527185 1983 dbSNP
rs927304883 1985 dbSNP
rs1425760709 2005 dbSNP
rs1400661956 2006 dbSNP
rs374132949 2011 dbSNP
rs1329897635 2012 dbSNP
rs186162549 2014 dbSNP
rs1179190330 2026 dbSNP
rs753189767 2026 dbSNP
rs1340190325 2027 dbSNP
rs1057325790 2035 dbSNP
rs752562635 2036 dbSNP
rs1365331598 2039 dbSNP
rs1182344904 2042 dbSNP
rs1441620359 2046 dbSNP
rs1057266099 2048 dbSNP
rs994374897 2050 dbSNP
rs1461404382 2054 dbSNP
rs1266884707 2062 dbSNP
rs1303590538 2062 dbSNP
rs1221730025 2063 dbSNP
rs373411787 2078 dbSNP
rs949010792 2082 dbSNP
rs1244589563 2086 dbSNP
rs1388021565 2086 dbSNP
rs570711169 2086 dbSNP
rs1233644525 2088 dbSNP
rs1318553793 2089 dbSNP
rs1274238276 2095 dbSNP
rs1044712651 2098 dbSNP
rs1218247732 2099 dbSNP
rs1286094454 2101 dbSNP
rs1015989836 2104 dbSNP
rs1185371120 2112 dbSNP
rs1445107551 2112 dbSNP
rs1246888575 2116 dbSNP
rs1487643658 2125 dbSNP
rs570231907 2128 dbSNP
rs964744581 2131 dbSNP
rs1284578148 2133 dbSNP
rs1434167610 2138 dbSNP
rs904869854 2144 dbSNP
rs995806991 2147 dbSNP
rs1044706 2153 dbSNP
rs1198559244 2153 dbSNP
rs1030002185 2154 dbSNP
rs1393874747 2155 dbSNP
rs954647559 2164 dbSNP
rs758373556 2166 dbSNP
rs1323179478 2167 dbSNP
rs988716153 2167 dbSNP
rs1048173801 2172 dbSNP
rs1171814460 2180 dbSNP
rs74999026 2181 dbSNP
rs1417893648 2184 dbSNP
rs1004039252 2185 dbSNP
rs1389540000 2187 dbSNP
rs1184685823 2194 dbSNP
rs1476130966 2194 dbSNP
rs558720705 2195 dbSNP
rs751563885 2202 dbSNP
rs1197746469 2205 dbSNP
rs1491380669 2205 dbSNP
rs1223768344 2206 dbSNP
rs927367464 2206 dbSNP
rs937341254 2206 dbSNP
rs1019484593 2212 dbSNP
rs965303744 2219 dbSNP
rs1387180409 2222 dbSNP
rs992826782 2224 dbSNP
rs757268842 2230 dbSNP
rs781399665 2231 dbSNP
rs1274272511 2234 dbSNP
rs1403343256 2235 dbSNP
rs1303968358 2237 dbSNP
rs1347693883 2237 dbSNP
rs1425117512 2238 dbSNP
rs1353676211 2244 dbSNP
rs1397396312 2249 dbSNP
rs546491722 2250 dbSNP
rs1309807852 2251 dbSNP
rs1411540981 2251 dbSNP
rs1419627276 2252 dbSNP
rs1047282710 2259 dbSNP
rs1479164274 2264 dbSNP
rs1270661172 2267 dbSNP
rs759800167 2268 dbSNP
rs941507971 2268 dbSNP
rs1028292545 2269 dbSNP
rs969126784 2274 dbSNP
rs1207261191 2275 dbSNP
rs191961634 2275 dbSNP
rs978771738 2276 dbSNP
rs566013860 2280 dbSNP
rs1236223422 2283 dbSNP
rs1266880442 2286 dbSNP
rs879783012 2287 dbSNP
rs1284210780 2288 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 55664.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55664.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000381854.3 | 3UTR | UUUUGUAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000381854.3 | 3UTR | UAAAUUUUUUUUAAUGUGCUGCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
280 hsa-miR-4282 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057628 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT060732 RPS3 ribosomal protein S3 2 2
MIRT063371 ETNK1 ethanolamine kinase 1 2 2
MIRT066257 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT070774 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT070871 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT078056 PCTP phosphatidylcholine transfer protein 2 2
MIRT078408 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT084059 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT093537 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096072 SFXN1 sideroflexin 1 2 2
MIRT098316 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT100493 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT102254 HBP1 HMG-box transcription factor 1 2 4
MIRT105318 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT114143 MZT1 mitotic spindle organizing protein 1 2 4
MIRT114873 DICER1 dicer 1, ribonuclease III 2 2
MIRT134683 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT137640 RCOR1 REST corepressor 1 2 2
MIRT155449 CCNT2 cyclin T2 2 4
MIRT165656 DCTN4 dynactin subunit 4 2 2
MIRT177570 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT188514 E2F7 E2F transcription factor 7 2 10
MIRT193019 TMOD3 tropomodulin 3 2 4
MIRT195823 GADD45A growth arrest and DNA damage inducible alpha 2 2
MIRT195885 DEPDC1 DEP domain containing 1 2 6
MIRT206029 NUP50 nucleoporin 50 2 6
MIRT212148 CLCN3 chloride voltage-gated channel 3 2 2
MIRT213999 DCP2 decapping mRNA 2 2 2
MIRT214650 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT221568 CBX3 chromobox 3 2 2
MIRT224544 ZNF623 zinc finger protein 623 2 2
MIRT227654 SET SET nuclear proto-oncogene 2 2
MIRT229992 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT238968 QKI QKI, KH domain containing RNA binding 2 2
MIRT239825 ACTB actin beta 2 2
MIRT241084 ZXDA zinc finger, X-linked, duplicated A 2 4
MIRT244852 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT264534 TARDBP TAR DNA binding protein 2 2
MIRT271438 SKI SKI proto-oncogene 2 2
MIRT271597 ENAH ENAH, actin regulator 2 2
MIRT294332 ZNF264 zinc finger protein 264 2 2
MIRT296341 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT301715 TEF TEF, PAR bZIP transcription factor 2 2
MIRT308549 ZNF654 zinc finger protein 654 2 2
MIRT313866 DEPDC1B DEP domain containing 1B 2 2
MIRT315529 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT321066 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT343777 NUTF2 nuclear transport factor 2 2 2
MIRT359109 MAP1B microtubule associated protein 1B 2 2
MIRT397393 GOLGA3 golgin A3 2 4
MIRT400822 CPEB2 cytoplasmic polyadenylation element binding protein 2 2 2
MIRT442171 DSEL dermatan sulfate epimerase-like 2 2
MIRT442777 JAG1 jagged 1 2 2
MIRT442862 SCARF1 scavenger receptor class F member 1 2 4
MIRT442919 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT444567 TRA2B transformer 2 beta homolog 2 2
MIRT444718 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT445018 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT445853 LRRC1 leucine rich repeat containing 1 2 2
MIRT446242 HELZ helicase with zinc finger 2 2
MIRT446542 GOLGA8B golgin A8 family member B 2 2
MIRT446643 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT446948 ZMAT3 zinc finger matrin-type 3 2 4
MIRT447061 KCNAB1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 2 2
MIRT447327 ZSCAN21 zinc finger and SCAN domain containing 21 2 2
MIRT447995 CDX1 caudal type homeobox 1 2 2
MIRT448543 RHEBP1 RHEB pseudogene 1 2 6
MIRT448752 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT448772 GOLGA8A golgin A8 family member A 2 2
MIRT449342 WDR26 WD repeat domain 26 2 2
MIRT450011 SLC16A6 solute carrier family 16 member 6 2 4
MIRT450229 PCNX pecanex homolog 1 2 2
MIRT450340 MRPL17 mitochondrial ribosomal protein L17 2 4
MIRT450381 MSI2 musashi RNA binding protein 2 2 2
MIRT450759 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT450809 NRCAM neuronal cell adhesion molecule 2 2
MIRT450947 ATAD2 ATPase family, AAA domain containing 2 2 2
MIRT459095 CCPG1 cell cycle progression 1 2 2
MIRT462428 TWISTNB TWIST neighbor 2 2
MIRT465200 TROVE2 TROVE domain family member 2 2 4
MIRT467382 SON SON DNA binding protein 2 4
MIRT468546 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT471506 PDE4D phosphodiesterase 4D 2 2
MIRT471981 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT474478 KLHL11 kelch like family member 11 2 8
MIRT475011 KANSL1 KAT8 regulatory NSL complex subunit 1 2 8
MIRT480341 C5orf51 chromosome 5 open reading frame 51 2 2
MIRT482696 TEX9 testis expressed 9 2 6
MIRT483462 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 6
MIRT485623 FAM217B family with sequence similarity 217 member B 2 2
MIRT485714 CASP16 caspase 16, pseudogene 2 8
MIRT486279 SEC23A Sec23 homolog A, coat complex II component 2 2
MIRT491000 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT492594 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT493365 KIF5B kinesin family member 5B 2 2
MIRT494316 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT495208 EDN3 endothelin 3 2 2
MIRT497011 TCF15 transcription factor 15 2 2
MIRT498512 FRK fyn related Src family tyrosine kinase 2 2
MIRT498778 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT501045 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 6
MIRT502939 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504806 VHL von Hippel-Lindau tumor suppressor 2 6
MIRT505656 SHMT1 serine hydroxymethyltransferase 1 2 6
MIRT505964 RAB5C RAB5C, member RAS oncogene family 2 6
MIRT506322 OTUD4 OTU deubiquitinase 4 2 4
MIRT506803 KLHL15 kelch like family member 15 2 6
MIRT506917 KBTBD8 kelch repeat and BTB domain containing 8 2 4
MIRT507400 EMC7 ER membrane protein complex subunit 7 2 8
MIRT507471 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 6
MIRT508058 ATP13A3 ATPase 13A3 2 4
MIRT508135 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT509895 RPS23 ribosomal protein S23 2 4
MIRT510881 RAN RAN, member RAS oncogene family 2 8
MIRT513766 PEX5L peroxisomal biogenesis factor 5 like 2 4
MIRT516898 COPS8 COP9 signalosome subunit 8 2 2
MIRT518703 TIMD4 T-cell immunoglobulin and mucin domain containing 4 2 4
MIRT520429 TTPAL alpha tocopherol transfer protein like 2 6
MIRT521843 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT522116 NUDT3 nudix hydrolase 3 2 4
MIRT525467 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT525583 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT525906 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT526072 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT526232 MTRNR2L5 MT-RNR2-like 5 2 4
MIRT526455 FAM71F2 family with sequence similarity 71 member F2 2 4
MIRT526515 POU5F1B POU class 5 homeobox 1B 2 2
MIRT528032 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT528422 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT528995 ISLR2 immunoglobulin superfamily containing leucine rich repeat 2 2 4
MIRT529311 ATRNL1 attractin like 1 2 2
MIRT529376 SKP1 S-phase kinase associated protein 1 2 4
MIRT530015 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT530089 FMN2 formin 2 2 2
MIRT530942 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 2
MIRT531229 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT533088 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT533299 USP46 ubiquitin specific peptidase 46 2 2
MIRT533318 UNKL unkempt family like zinc finger 2 2
MIRT533721 TMEM30A transmembrane protein 30A 2 2
MIRT534096 AZF1 azoospermia factor 1 2 2
MIRT534188 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534493 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT536077 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT536242 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT537524 FAM104A family with sequence similarity 104 member A 2 2
MIRT538088 DGKH diacylglycerol kinase eta 2 2
MIRT538475 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT538853 BTG1 BTG anti-proliferation factor 1 2 4
MIRT539075 GDNF glial cell derived neurotrophic factor 2 2
MIRT539480 ACVR2B activin A receptor type 2B 2 4
MIRT540210 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT541940 TSPAN2 tetraspanin 2 2 2
MIRT543812 COCH cochlin 2 2
MIRT545120 PDZRN4 PDZ domain containing ring finger 4 2 2
MIRT545571 GIMAP4 GTPase, IMAP family member 4 2 2
MIRT545989 XKR4 XK related 4 2 2
MIRT547213 PANK3 pantothenate kinase 3 2 4
MIRT547740 KIAA1468 KIAA1468 2 2
MIRT548022 GRB2 growth factor receptor bound protein 2 2 4
MIRT548032 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548102 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT548217 FKBP1A FK506 binding protein 1A 2 2
MIRT548588 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT548953 CDC27 cell division cycle 27 2 2
MIRT549072 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT550368 INCENP inner centromere protein 2 6
MIRT550546 MYZAP myocardial zonula adherens protein 2 2
MIRT551491 TMEM192 transmembrane protein 192 2 4
MIRT553078 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT554104 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555127 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT555477 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT555978 NPTN neuroplastin 2 2
MIRT557011 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT557706 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT558333 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558488 DBN1 drebrin 1 2 2
MIRT559942 ZNF567 zinc finger protein 567 2 2
MIRT561127 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT561791 PAWR pro-apoptotic WT1 regulator 2 2
MIRT562438 EEF2 eukaryotic translation elongation factor 2 2 2
MIRT563102 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT563212 ZNF813 zinc finger protein 813 2 2
MIRT563426 KIF3A kinesin family member 3A 2 2
MIRT563473 SPIN4 spindlin family member 4 2 2
MIRT564015 HSPA4 heat shock protein family A (Hsp70) member 4 2 4
MIRT564117 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT564223 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT564503 CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1 2 2
MIRT564515 DUSP3 dual specificity phosphatase 3 2 2
MIRT564811 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT565265 TPD52 tumor protein D52 2 2
MIRT566012 RHOB ras homolog family member B 2 2
MIRT566216 PTMA prothymosin, alpha 2 2
MIRT566638 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT566821 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT566948 LEPROT leptin receptor overlapping transcript 2 2
MIRT567290 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT567895 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT568731 MTRNR2L3 MT-RNR2-like 3 2 2
MIRT571263 ZNF239 zinc finger protein 239 2 2
MIRT572593 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2 2
MIRT573827 TGOLN2 trans-golgi network protein 2 2 2
MIRT576391 Fhl2 four and a half LIM domains 2 2 2
MIRT609901 SMS spermine synthase 2 2
MIRT613710 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT614406 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT615042 DCX doublecortin 2 2
MIRT617514 C5orf45 MRN complex interacting protein 2 2
MIRT619476 PRDM10 PR/SET domain 10 2 2
MIRT620349 TLN1 talin 1 2 2
MIRT620910 PLA2G7 phospholipase A2 group VII 2 2
MIRT622131 SP4 Sp4 transcription factor 2 2
MIRT622955 OTUD7B OTU deubiquitinase 7B 2 2
MIRT623351 MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2 2
MIRT623619 INTU inturned planar cell polarity protein 2 2
MIRT624409 CCDC171 coiled-coil domain containing 171 2 2
MIRT625171 CCS copper chaperone for superoxide dismutase 2 2
MIRT625685 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT625875 ALDH18A1 aldehyde dehydrogenase 18 family member A1 2 2
MIRT626002 FAM107A family with sequence similarity 107 member A 2 2
MIRT626872 HRH4 histamine receptor H4 2 4
MIRT628220 FKBP9 FK506 binding protein 9 2 2
MIRT628265 DIO2 iodothyronine deiodinase 2 2 2
MIRT628402 C8orf37 chromosome 8 open reading frame 37 2 2
MIRT630564 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT631577 RASSF9 Ras association domain family member 9 2 2
MIRT635730 CCDC58 coiled-coil domain containing 58 2 2
MIRT636224 SLC8A1 solute carrier family 8 member A1 2 2
MIRT636613 CLIC5 chloride intracellular channel 5 2 2
MIRT638899 CDK9 cyclin dependent kinase 9 2 2
MIRT640167 ATXN7L1 ataxin 7 like 1 2 2
MIRT642070 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT643034 CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2 2
MIRT644572 SPOP speckle type BTB/POZ protein 2 2
MIRT644954 IFNB1 interferon beta 1 2 2
MIRT645948 TTF2 transcription termination factor 2 2 2
MIRT646440 XRCC2 X-ray repair cross complementing 2 2 2
MIRT647896 EPN2 epsin 2 2 2
MIRT648276 ZNF582 zinc finger protein 582 2 2
MIRT649381 NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2 2
MIRT650254 CD68 CD68 molecule 2 2
MIRT650333 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT651707 VMP1 vacuole membrane protein 1 2 2
MIRT651774 VASP vasodilator stimulated phosphoprotein 2 2
MIRT653144 SRPK2 SRSF protein kinase 2 2 2
MIRT654112 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654161 RORB RAR related orphan receptor B 2 2
MIRT655716 MLF2 myeloid leukemia factor 2 2 2
MIRT657476 HDAC4 histone deacetylase 4 2 2
MIRT658095 FOXO1 forkhead box O1 2 2
MIRT658860 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT658988 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 2
MIRT660767 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT661622 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661694 TFDP2 transcription factor Dp-2 2 2
MIRT662208 PLA2G4E phospholipase A2 group IVE 2 2
MIRT662443 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664422 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT687505 NECAB1 N-terminal EF-hand calcium binding protein 1 2 2
MIRT689910 SOD2 superoxide dismutase 2 2 2
MIRT690781 PLA2G2C phospholipase A2 group IIC 2 2
MIRT698488 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT699685 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT700926 PDS5A PDS5 cohesin associated factor A 2 2
MIRT702258 LMNB1 lamin B1 2 2
MIRT703166 GPR137C G protein-coupled receptor 137C 2 2
MIRT703242 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT704737 CENPQ centromere protein Q 2 2
MIRT707310 GLRX2 glutaredoxin 2 2 2
MIRT710021 KCNQ5 potassium voltage-gated channel subfamily Q member 5 2 2
MIRT712212 SCOC short coiled-coil protein 2 2
MIRT714742 SETBP1 SET binding protein 1 2 2
MIRT718268 ZNF749 zinc finger protein 749 2 2
MIRT720553 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT722248 RBM41 RNA binding motif protein 41 2 2
MIRT723767 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT723977 KIAA0146 scaffolding protein involved in DNA repair 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4282 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)

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