miRTarBase - #MIRT502956


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pre-miRNA Information
pre-miRNA hsa-mir-2116   
Genomic Coordinates chr15: 59171183 - 59171262
Description Homo sapiens miR-2116 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2116-5p
Sequence 14| GGUUCUUAGCAUAGGAGGUCU |34
Evidence Experimental
Experiments 454
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 15 - 59171242 29233923 MiREDiBase
A-to-I 13 15 - 59171237 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1217966510 1 dbSNP
rs1170901508 3 dbSNP
rs1364783161 5 dbSNP
rs1240890962 11 dbSNP
rs537360898 13 dbSNP
rs776323490 17 dbSNP
Putative Targets

Gene Information
Gene Symbol CCNT2   
Synonyms CYCT2
Description cyclin T2
Transcript NM_001241   
Other Transcripts NM_058241   
Expression
Putative miRNA Targets on CCNT2
3'UTR of CCNT2
(miRNA target sites are highlighted)		 
>CCNT2|NM_001241|3'UTR
   1 TGCCAATCACGAGTACAGTACAAGCAGCCAGCATATGGACTACAAAGACACATTCGACATGCTGGACTCACTGTTAAGTG
  81 CCCAAGGAATGAACATGTAATAATTTGTTTAGGTCAATTTTTCCTTTACTTTTTTAATTTAAAAATTGTTAGAATGGAAA
 161 AATTCCTTCTGATCTAGCAGTGGTAACCCCTGCTGTTGCTGCCACTGCTTCAATATTTGTAAGTGCTGCTTTATTCTTCA
 241 TTCTGAAAAGAAGAGATTATAGTAAACAAGTCTTTATCTCCACATATGATAGTGTTATAAATACTGTAAAAGCATGGAAG
 321 GTGCAAAACTCAGTATTTCTACAATTGCAGCTAAGAACATTAGGATGAATGGCTGGCTGCTTCTAGGAATATAAGATGCC
 401 TCAAGCATTCATTATTTATGATTTGAATACTGTAGCTATTTTTTGTTGCTTGGCTTTTGAATGAGTGTAAATTGTTTTCT
 481 TTTGTGTATTTATACTTGTATGTATGATTTGCATGTTTCAATGATAAAGGGATAAAACAGTATACTGACAACTGTTTACA
 561 AGAAAGTGGAGAAAAATGTACATACATTTTTGTATGTTTAGATATTACCGTAAATACTCAGGATTGGAGCTGCTTGTAAG
 641 TATAACAATATACAGAATAACTTTATTTTATCTTGTCAGAGTCCATCACTAATCTAAAACAAAGGTGGCACTTTTTTATG
 721 TTAACCTTAAACTCTAGGCCTTACTGGAAGCCACTGATAGGGGACACTTCACTACCAGATGTGTGCAGTGCAACAGATGG
 801 TCATATACACTGTGAGGCACTGAAATTTTGCCTTCAGAGGTTCTGACCAGATTGGCTGCTGAAATAGCCCCTAACTTTCT
 881 GAAGGCTTGAAGAGGAAAAAATAAAGTTTACATACTCTTGATGTGAAGTGCATTTAAATGTTTGTTGGCTTGTTGCAGTT
 961 CTATGAAACAGAGCTGTTAATAATGGTTATGTGGATTACTGTGATTTGAAAACTAAATTCACAATAACTTACCTAGTAGA
1041 GATTTAGTGAGTTGTTTCCTTTAAAGAATTTTACACTACATATTTTAATAGTAAACAGGGATCACTTTTCCTTTAGCATT
1121 CAGAATGACACCATATTCTTAAATATACTCCTTCCCTGAAGCGTGTTTGTGTGTGATGCCATATTTCTTTTTCAGGTAAA
1201 TGTAGTCTTCCTTATAAAAATGAAATTAAACCTATGCTCTCAATTCTTTTATATTCTAACAATAAATAAAAAAGAAAAGA
1281 TTACTGACTGTGCATTGTACCTGTATTTATAGTTTATGGTTATCAGGAAGCTCTGTAAGAAAGAAAAGGTCAGCCTCCCA
1361 GGCAAACCAGTAGTGGAGGTTTTACATTTGTTTGCACATCTCAGTATATTTCTGTTGAGGTAAAGTTTGCACAGTCATCT
1441 GACTTCTGATCAAGCATTAGATTTTAACTTGTTTAGATTTTGTCTTAAACACCAGTAATATGGCTCTTGTTTATCAGCTA
1521 ATCTTGAATTTATTCTGTGGTAAATCTTTTGAGTTGTTGAGTATATTTGAGATTGATTGGATTCGACCTCTTGTTGAACT
1601 GAAAACTTAATTTTTTCTCTGTATTTTTGTTACAAAGCCACTGATACGTGCACAATTGTAATTAAGTATGTTGCAGTTGT
1681 AAATATTAGAGTTTAATCTCATGCTCTACCTTTATTTAGCAATTACCTAATTTGCCAGTAGCTTTATAATTTTTAAAGAT
1761 AATTGTTCATTATTTTGTCAATGTTATTTGAACTTGGGGTACTTAGGAGCCTCTTTGTAGGGACTGTGCCTAGGTAGCAT
1841 GTCCTAACATTTGTTCTGGTCTTGCATAACTTCAGTAATCTTTGTCATTATATGTAACTTTGTTGCTCTGTATGGCATAA
1921 TATTGTATCCATAAACATGGTAATTTTGATACAGTTATACTTTTACAGTGGTACATAATCCAAGGACTAGTATAGAATTA
2001 AGCTGAGTGCAAGATGAGGGAGGGAAGGGCTTTCTTGGTAATTTAGATGTGAAACCTCTACAGAGCTATCATGTAAAAAC
2081 TACATAAGGTGGTTGTGCTACTGTATAATTGGGGGTGATAATACCAGGAATTTTAATAAGATTTTGTAAAGAATATCCAG
2161 AAAAGTAGTGAACTTATTTTCAGTAGACATAGAAAACAATGTGAATATTTAAGGTCTGTGACTATAGTTAAACTTCACTA
2241 AGAATTTGCAGAATTGTTTTGAGATGTGTGAATAAAGGTAATTTTATTGAATCTTCATTGGTGCTAATGATGGACAGTTA
2321 AAAAGATAGCTAGTGTATATTGTTATGGGTCAGTACTTATTAGTACTTCCAAAATTGAATTTGAAATGCTATGTATTCAC
2401 TTTTCACTCTGTAAATGTAATTCTTTACAATGACTTTATTTATTAAAGGGCAGCCAGTTGTCATTTTTACAGGATTGTGT
2481 GAGCTATTCAAACTCTTCAACCCCTGAACAGGGTATTAAGCTTCCAAAATAATGATGGGGATAAATATGGAAATCCTTTT
2561 TAAGTTGTATTTCCATTAAACAAAAACCCTTATAATTCATACTATCATGAATTTGCTTTATCCATCTCATTTGCATAACA
2641 GTTCATCTGTCTGGTCCCATTAGGCTCTACCAAAGAAAGACTCTGATGAGTGGACATTATTACTGTGACTCTTGTAAGTA
2721 GCCATAAATAAACCAAAATAGTATCAAATTTAGGTATGAAATTCCACATGTGCAAAGTACTGTTAAGGTGATAACATTTT
2801 TGATGAGATTTAAAAAAATATTTGAAATATTAAAAAGCATTATCTTTAAACATCCTATAAAAGAGTGAGTCATTTTTAAG
2881 TTGTGTTTTCCCTAGATCACTGATTTGTTACCTTTACACAGAAGCACATTGCAAAGAAAGGCTTTATTTCTACCTCTTCC
2961 ATTCAGTTTTCCAATATTGAGCTGTGTCCCTCTGAATATTTGCCTTAGCTATTTCAAAATAGGTATTTTCAGAACCAAAG
3041 CAAAGGGTGGTTTGTTCACTGAAACATTCTTAGAGGCCTACTTAACGGGCGGCAGTATCCGGTAGTGGTAAAACCTCACA
3121 GTTTCCTAATTGCAGGTATGTAAATACCAAAAAAGTCCTGTTGTCAGCCCTAGGTTTATCTTTGAAAGCAGTTAAATGTG
3201 CACCTTGGTCTTCCTCCGTGTGTTCAGATTCCTTCTGGTTAAAGTTCTTATTCAGAGTCATCTAAAAGAAATTTCTAACA
3281 TGATGTATGGTTTCTTGAATGTCATGAGTGGCTGCGTATATTGCTTTGTAGCAACAGATTGTATTAATAATTAATAGAAT
3361 ACCTAATTTTTTTGGCCTATCCTCTTTGAACTAGAAATGACTACTTGAGGGCTATTTCAGAGAACCAATATGAAATGTTT
3441 TTGTTAGTACAAAATACCATTGCCTTAAAAGGTTTCAAGCACATTTTCTTTTCTATTTGAGAACTTAAATTGCTGACTTG
3521 TATTCGTTAAGCAACCTTAGAAATAAACCACTGCTTATATCTGCATGAATATTATGCATTTCATGAGTACAGTTAGTTGA
3601 TTAGATATTTCAGGGTTTTGCATTTTCTATAGACATGGGGACTTTTTTAACATGGTAACGTCTTAGGAAAACCATTCTCT
3681 CAAGGTATTACACCATTTCCAATTTTATCCAAATGAAAAGCATATCTGCTTAAATTTAGGATGTCTTTGCTGAGAATATT
3761 TGGAGGCTCTTGTTAGGAAGAATCATGGATTCAGTATTTCTAACCTGATTACTGCCTCAGAGGCTGTCTTGAAGGGAGAC
3841 AGTAGGATTCACTGACTACCTTTACCCAGATGAGGGATCAACAAATCTCACACTTAAACTAAATGAGTTGACAGGACAAT
3921 AGGTGCTAATCTCATGTGCCCTAAGATGGACTTATTTAGATAGGGATTTTTGCATTGGAAAAGCAGCACATTCTCTGACC
4001 TTGGGTACCAAGCTATGATACTAATTTGAGAATCACATTCTGATACGTTAATATCAGAAATCAGTGAGCAACCTAATTGC
4081 TGTAAGCTGACATACATGGAAGCCGAAATCAAAAGGTTGCTTTTGTTAGTTTCCCTGGAGCATCTATTTTTGTAATACAT
4161 TTTGCCAGTGGGACTGAAAAGCTCAAAATGTTTTAGACCTAATATCATACATTAATTTTCTGCTCTGCAGTGTCAATTTG
4241 GGCACAGCCAGTTTTTACCTCTGTGGCACCTTCTTTATAATTTACTGTTACCTATTCTGCCTGACAGATTGATTAAGTAG
4321 GTTGATAAGATCCATCGAAGATTGAATGGCTAGGAGTAATTCTGTTCTCGTATAGGCAACTTAACTTCACTGTGGAATCC
4401 ATTTATCTCAAAGTTTGAGGGCTGTCTACTTTATTTTCAAGTTTGGGGCGGAAACTCAAAATCCCGAGCATTGCCACTTT
4481 AGTAGTTTGTTTGATTTGCCTATTGTTTAATAATGAGTACATTCTTATTAAGTGATGAGTACATTCTTAATTTTAAGGTA
4561 TGTTTTTTTCAAGCAGCTTCATTTTATTAGGAAAAATACATACTCATTTGTTGTAAACAGTGATTGTGGGGTTTCATTTT
4641 CTGAATGTACTCAAAACTCCCAACAACAATTGAACAGGATGTTTGCTAATAGAAAATCTAAAACAGGAATATGTGTATAT
4721 GGCATGAATTAGTCATTGACTTTAAGCTTCTTATCCATACAAGGAACTAATAAAATGTTTATTGACAACATAAATCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuGGAGGAUA----CGAUUCUUGg 5'
             :|| | ||    ||||||||| 
Target 5' attTCTACAATTGCAGCTAAGAACa 3'
 335 - 359 156.00 -12.70
2 
miRNA  3' ucuGGAGGAUACGAUUCUUGg 5'
             ::|:|||| :|:||||| 
Target 5' ttcTTTTCTAT-TTGAGAACt 3'
 3486 - 3505 145.00 -12.60
3 
miRNA  3' ucUGGAGGAUACGAUUCUUGg 5'
            ||:||  |  |||||||: 
Target 5' aaACTTC--A--CTAAGAATt 3'
 2230 - 2246 135.00 -10.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM3116031 2 COSMIC
COSM1006716 11 COSMIC
COSM1006718 12 COSMIC
COSM3364283 15 COSMIC
COSM1006720 28 COSMIC
COSM475924 35 COSMIC
COSM3836862 48 COSMIC
COSM204560 56 COSMIC
COSM7143202 56 COSMIC
COSM7654951 56 COSMIC
COSM7543506 57 COSMIC
COSM243544 70 COSMIC
COSM8540609 87 COSMIC
COSM9576464 98 COSMIC
COSM9188536 99 COSMIC
COSN30148548 120 COSMIC
COSN26969704 123 COSMIC
COSN13936734 124 COSMIC
COSN30463913 125 COSMIC
COSN31480419 133 COSMIC
COSN31602287 136 COSMIC
COSN20053995 140 COSMIC
COSN30113788 147 COSMIC
COSN31502778 153 COSMIC
COSN31500779 158 COSMIC
COSN17076401 167 COSMIC
COSN19372814 187 COSMIC
COSN31488170 205 COSMIC
COSN19656704 234 COSMIC
COSN26633131 237 COSMIC
COSN21910518 501 COSMIC
COSN505828 511 COSMIC
COSN17076402 513 COSMIC
COSN17076403 520 COSMIC
COSN27204412 663 COSMIC
COSN30173363 688 COSMIC
COSN26560218 831 COSMIC
COSN31517824 1028 COSMIC
COSN6210316 1163 COSMIC
COSN20097178 1271 COSMIC
COSN26533999 1272 COSMIC
COSN8758368 1280 COSMIC
COSN28684563 1285 COSMIC
COSN31520621 1308 COSMIC
COSN21477355 1462 COSMIC
COSN16615756 1585 COSMIC
COSN21341610 1602 COSMIC
COSN30172383 1644 COSMIC
COSN8607496 1704 COSMIC
COSN1789405 1874 COSMIC
COSN31593805 2030 COSMIC
COSN19420188 2122 COSMIC
COSN24299466 2166 COSMIC
COSN30172285 2193 COSMIC
COSN30164439 2243 COSMIC
COSN31481939 2252 COSMIC
COSN31524279 2356 COSMIC
COSN30172611 2378 COSMIC
COSN31593527 2462 COSMIC
COSN1789406 2729 COSMIC
COSN25392593 2739 COSMIC
COSN17585956 3022 COSMIC
COSN23703996 3353 COSMIC
COSN9859850 3399 COSMIC
COSN21959051 3438 COSMIC
COSN9081750 3719 COSMIC
COSN25639104 3743 COSMIC
COSN31959792 3873 COSMIC
COSN1789407 4097 COSMIC
COSN9228044 4271 COSMIC
COSN26145445 4318 COSMIC
COSN8268571 4374 COSMIC
COSN20765937 4398 COSMIC
COSN22681130 4410 COSMIC
COSN24936643 4646 COSMIC
COSN26028597 4720 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1454746248 7 dbSNP
rs764257111 11 dbSNP
rs190052933 12 dbSNP
rs779129544 17 dbSNP
rs750864313 18 dbSNP
rs1246622106 19 dbSNP
rs1356833612 22 dbSNP
rs138728360 24 dbSNP
rs902705598 26 dbSNP
rs758906908 27 dbSNP
rs759833063 28 dbSNP
rs1393848936 30 dbSNP
rs573586469 31 dbSNP
rs1308490329 32 dbSNP
rs371710293 35 dbSNP
rs919436797 36 dbSNP
rs1380582115 44 dbSNP
rs1266031052 48 dbSNP
rs183192820 49 dbSNP
rs761745981 50 dbSNP
rs1205810020 52 dbSNP
rs755143305 53 dbSNP
rs1483042526 56 dbSNP
rs781377317 57 dbSNP
rs748295924 68 dbSNP
rs769900810 70 dbSNP
rs770113338 72 dbSNP
rs1410233347 77 dbSNP
rs774013841 80 dbSNP
rs1177596534 81 dbSNP
rs745669184 82 dbSNP
rs1358266574 86 dbSNP
rs143713034 88 dbSNP
rs142947931 92 dbSNP
rs775436813 95 dbSNP
rs774335259 98 dbSNP
rs765410703 99 dbSNP
rs1409142978 101 dbSNP
rs1286305037 104 dbSNP
rs1191744587 106 dbSNP
rs45569737 107 dbSNP
rs763488978 108 dbSNP
rs776259001 109 dbSNP
rs761363968 111 dbSNP
rs1208237547 114 dbSNP
rs764944183 117 dbSNP
rs1354493855 120 dbSNP
rs758859505 125 dbSNP
rs766955567 126 dbSNP
rs1250335032 128 dbSNP
rs1481691501 130 dbSNP
rs1022852244 132 dbSNP
rs1192176983 133 dbSNP
rs45492201 135 dbSNP
rs752086123 136 dbSNP
rs888237574 138 dbSNP
rs1344101412 139 dbSNP
rs1268331114 140 dbSNP
rs13425686 141 dbSNP
rs368199418 148 dbSNP
rs35021589 158 dbSNP
rs1236149510 165 dbSNP
rs1331614232 169 dbSNP
rs1324231561 172 dbSNP
rs575756832 178 dbSNP
rs1302829470 185 dbSNP
rs555491013 185 dbSNP
rs950608180 189 dbSNP
rs1039395213 190 dbSNP
rs899470242 191 dbSNP
rs770678298 193 dbSNP
rs1439245630 196 dbSNP
rs568722241 200 dbSNP
rs998108952 204 dbSNP
rs1029546609 207 dbSNP
rs956606474 209 dbSNP
rs1489658743 213 dbSNP
rs752760002 214 dbSNP
rs1267702332 218 dbSNP
rs1009433921 225 dbSNP
rs1483911240 226 dbSNP
rs774154076 241 dbSNP
rs1270539417 243 dbSNP
rs908985166 246 dbSNP
rs962982199 250 dbSNP
rs974373320 259 dbSNP
rs1276588830 273 dbSNP
rs926640710 279 dbSNP
rs138622899 282 dbSNP
rs1166132574 287 dbSNP
rs921658600 288 dbSNP
rs992375466 293 dbSNP
rs528588155 294 dbSNP
rs547152471 299 dbSNP
rs933550892 301 dbSNP
rs368205222 303 dbSNP
rs1356509308 308 dbSNP
rs919549441 309 dbSNP
rs1052053666 313 dbSNP
rs1403489554 316 dbSNP
rs929552100 317 dbSNP
rs1179264402 322 dbSNP
rs1329663721 345 dbSNP
rs1049259977 347 dbSNP
rs1400038506 348 dbSNP
rs1182274917 349 dbSNP
rs1448070950 353 dbSNP
rs1230853394 360 dbSNP
rs1203521258 377 dbSNP
rs1442839227 380 dbSNP
rs1280635879 385 dbSNP
rs1201773880 386 dbSNP
rs924077541 392 dbSNP
rs1262529818 395 dbSNP
rs1229118110 396 dbSNP
rs935533670 402 dbSNP
rs1375745413 403 dbSNP
rs1230384362 405 dbSNP
rs1341502050 412 dbSNP
rs941132263 412 dbSNP
rs1339260206 413 dbSNP
rs1468637298 415 dbSNP
rs1053834572 416 dbSNP
rs1039825474 421 dbSNP
rs899502082 431 dbSNP
rs997889843 433 dbSNP
rs758848532 435 dbSNP
rs1405317784 436 dbSNP
rs1012369517 445 dbSNP
rs1176326857 464 dbSNP
rs774980855 465 dbSNP
rs1045083593 468 dbSNP
rs906556677 470 dbSNP
rs892414663 475 dbSNP
rs1181541274 477 dbSNP
rs1248605587 480 dbSNP
rs1460781649 480 dbSNP
rs1209399458 487 dbSNP
rs1003189020 489 dbSNP
rs759269267 495 dbSNP
rs1457140813 501 dbSNP
rs1199088527 505 dbSNP
rs950582509 506 dbSNP
rs1223496917 507 dbSNP
rs1317537326 512 dbSNP
rs1004675690 522 dbSNP
rs1382655377 531 dbSNP
rs1321863071 532 dbSNP
rs34968802 534 dbSNP
rs1450121976 539 dbSNP
rs1016085922 543 dbSNP
rs1378297504 553 dbSNP
rs963096101 558 dbSNP
rs974489439 564 dbSNP
rs1157744288 578 dbSNP
rs1033687945 579 dbSNP
rs921584079 579 dbSNP
rs960777151 581 dbSNP
rs562092713 582 dbSNP
rs992154233 587 dbSNP
rs1248541105 593 dbSNP
rs1423619894 603 dbSNP
rs1486885721 606 dbSNP
rs1240362293 611 dbSNP
rs919247101 613 dbSNP
rs1294259545 614 dbSNP
rs1244210835 616 dbSNP
rs1359245281 627 dbSNP
rs951021877 637 dbSNP
rs1216769348 642 dbSNP
rs1466451249 648 dbSNP
rs1333839863 649 dbSNP
rs545325932 653 dbSNP
rs1436615913 656 dbSNP
rs1367022004 657 dbSNP
rs1398123519 658 dbSNP
rs529292963 661 dbSNP
rs1390627826 662 dbSNP
rs985423957 662 dbSNP
rs187480012 671 dbSNP
rs1172273496 680 dbSNP
rs1384728512 682 dbSNP
rs1322230671 693 dbSNP
rs909389194 696 dbSNP
rs375861354 697 dbSNP
rs376925647 697 dbSNP
rs569066801 718 dbSNP
rs954417841 721 dbSNP
rs988107303 726 dbSNP
rs1317259231 732 dbSNP
rs924222505 735 dbSNP
rs921048142 752 dbSNP
rs933713419 753 dbSNP
rs1490249504 757 dbSNP
rs1252195167 758 dbSNP
rs1252880314 759 dbSNP
rs1354443051 762 dbSNP
rs1209475907 764 dbSNP
rs1306234033 764 dbSNP
rs192617639 771 dbSNP
rs935450438 775 dbSNP
rs1053948124 776 dbSNP
rs1223565370 778 dbSNP
rs1346905054 780 dbSNP
rs915450639 782 dbSNP
rs1050770083 791 dbSNP
rs948098587 794 dbSNP
rs554571211 800 dbSNP
rs1370800042 802 dbSNP
rs1299619162 807 dbSNP
rs1045180582 810 dbSNP
rs1460303080 813 dbSNP
rs906498091 817 dbSNP
rs1003563846 818 dbSNP
rs767434147 831 dbSNP
rs886350718 851 dbSNP
rs1191660508 859 dbSNP
rs892112018 870 dbSNP
rs1480206533 871 dbSNP
rs945324317 871 dbSNP
rs1004796687 872 dbSNP
rs1179292181 874 dbSNP
rs1016033777 876 dbSNP
rs1479893401 876 dbSNP
rs1044004687 881 dbSNP
rs539572409 882 dbSNP
rs1326283718 886 dbSNP
rs1260638361 892 dbSNP
rs1222394451 896 dbSNP
rs1335938439 901 dbSNP
rs1308746384 903 dbSNP
rs1389438750 923 dbSNP
rs903688907 926 dbSNP
rs1303216520 928 dbSNP
rs1002488832 936 dbSNP
rs764618731 939 dbSNP
rs896603807 940 dbSNP
rs1162264628 946 dbSNP
rs183758332 964 dbSNP
rs16831178 969 dbSNP
rs1161625207 975 dbSNP
rs1028762320 983 dbSNP
rs1417696335 987 dbSNP
rs954489379 990 dbSNP
rs1184604876 1004 dbSNP
rs987165215 1025 dbSNP
rs1241865261 1029 dbSNP
rs1356751250 1044 dbSNP
rs1339704655 1045 dbSNP
rs1350824085 1046 dbSNP
rs1031116104 1050 dbSNP
rs1400555489 1055 dbSNP
rs1236350782 1056 dbSNP
rs1016966023 1063 dbSNP
rs964982003 1066 dbSNP
rs543129768 1081 dbSNP
rs775296876 1104 dbSNP
rs974934790 1112 dbSNP
rs1380454104 1119 dbSNP
rs923412608 1121 dbSNP
rs1338485666 1124 dbSNP
rs1057045 1131 dbSNP
rs35582507 1133 dbSNP
rs933744681 1134 dbSNP
rs1057046 1139 dbSNP
rs533625087 1141 dbSNP
rs555067786 1157 dbSNP
rs956938258 1162 dbSNP
rs760262047 1163 dbSNP
rs1451820861 1164 dbSNP
rs1243868673 1168 dbSNP
rs1363460891 1174 dbSNP
rs1446863248 1182 dbSNP
rs1292593061 1188 dbSNP
rs1266240009 1195 dbSNP
rs1183575948 1197 dbSNP
rs989752992 1201 dbSNP
rs188933185 1202 dbSNP
rs1485319459 1227 dbSNP
rs1292107307 1235 dbSNP
rs1247874169 1238 dbSNP
rs1285410874 1239 dbSNP
rs948213857 1244 dbSNP
rs981240200 1247 dbSNP
rs141432868 1250 dbSNP
rs567575680 1252 dbSNP
rs1314283139 1255 dbSNP
rs1227978907 1261 dbSNP
rs766490592 1264 dbSNP
rs3835806 1268 dbSNP
rs397897552 1268 dbSNP
rs1320311838 1269 dbSNP
rs1423571854 1271 dbSNP
rs199541612 1271 dbSNP
rs1188725866 1272 dbSNP
rs1360097260 1272 dbSNP
rs369701459 1277 dbSNP
rs372676768 1278 dbSNP
rs376149925 1280 dbSNP
rs1304032905 1285 dbSNP
rs1293127100 1286 dbSNP
rs1426931859 1287 dbSNP
rs781537209 1292 dbSNP
rs192369693 1298 dbSNP
rs1163357539 1306 dbSNP
rs1476000056 1311 dbSNP
rs1047055611 1313 dbSNP
rs903805350 1315 dbSNP
rs937929955 1320 dbSNP
rs1385425433 1321 dbSNP
rs1054908386 1323 dbSNP
rs1224347489 1326 dbSNP
rs887133394 1334 dbSNP
rs1290683486 1345 dbSNP
rs896301382 1358 dbSNP
rs1013638223 1359 dbSNP
rs753909478 1369 dbSNP
rs1419855038 1371 dbSNP
rs1290550327 1373 dbSNP
rs202233834 1385 dbSNP
rs1026316462 1387 dbSNP
rs940599895 1395 dbSNP
rs576956155 1401 dbSNP
rs1284158523 1404 dbSNP
rs1395207529 1409 dbSNP
rs886522506 1421 dbSNP
rs1385186691 1426 dbSNP
rs775061890 1429 dbSNP
rs1323264110 1430 dbSNP
rs11896922 1431 dbSNP
rs1308888145 1432 dbSNP
rs1016253334 1433 dbSNP
rs898982012 1434 dbSNP
rs1254734420 1444 dbSNP
rs1464649436 1444 dbSNP
rs965354094 1449 dbSNP
rs996029081 1462 dbSNP
rs546560644 1472 dbSNP
rs1030516141 1497 dbSNP
rs1267770028 1509 dbSNP
rs954824266 1510 dbSNP
rs150779494 1514 dbSNP
rs1009100030 1518 dbSNP
rs1195226863 1522 dbSNP
rs1030646181 1524 dbSNP
rs1263781200 1524 dbSNP
rs1225465382 1540 dbSNP
rs1343842645 1548 dbSNP
rs1176395147 1557 dbSNP
rs956386874 1565 dbSNP
rs1379367800 1566 dbSNP
rs139159787 1585 dbSNP
rs3769023 1586 dbSNP
rs969504823 1591 dbSNP
rs1407497554 1595 dbSNP
rs755707531 1596 dbSNP
rs980971636 1610 dbSNP
rs979537069 1612 dbSNP
rs928162066 1616 dbSNP
rs1282639192 1620 dbSNP
rs1357319610 1634 dbSNP
rs1424001151 1636 dbSNP
rs939432588 1638 dbSNP
rs983299806 1641 dbSNP
rs924955143 1648 dbSNP
rs908520768 1649 dbSNP
rs1230898061 1663 dbSNP
rs1337070138 1663 dbSNP
rs559228484 1667 dbSNP
rs1461680381 1669 dbSNP
rs1244934729 1676 dbSNP
rs937950178 1677 dbSNP
rs1054939375 1691 dbSNP
rs529899510 1702 dbSNP
rs1224475524 1704 dbSNP
rs917751024 1711 dbSNP
rs562056094 1719 dbSNP
rs941382909 1727 dbSNP
rs1037539543 1735 dbSNP
rs899093305 1741 dbSNP
rs1449820226 1742 dbSNP
rs886551489 1743 dbSNP
rs1330906824 1752 dbSNP
rs1318412884 1766 dbSNP
rs779453351 1767 dbSNP
rs1006285341 1769 dbSNP
rs1157794884 1772 dbSNP
rs1050272307 1777 dbSNP
rs529247126 1782 dbSNP
rs1299306677 1788 dbSNP
rs1312060974 1811 dbSNP
rs1181747518 1820 dbSNP
rs1008636196 1832 dbSNP
rs1482886569 1833 dbSNP
rs544281548 1840 dbSNP
rs1216622665 1845 dbSNP
rs892113850 1860 dbSNP
rs996437406 1867 dbSNP
rs1239852280 1874 dbSNP
rs1360691664 1892 dbSNP
rs538180607 1895 dbSNP
rs1317774849 1902 dbSNP
rs1030550476 1903 dbSNP
rs1198474398 1909 dbSNP
rs1379100333 1920 dbSNP
rs1270231943 1921 dbSNP
rs954941350 1922 dbSNP
rs1343049779 1924 dbSNP
rs1465889720 1926 dbSNP
rs1297259287 1932 dbSNP
rs1425059222 1934 dbSNP
rs1010444900 1946 dbSNP
rs1161454361 1951 dbSNP
rs1020441446 1952 dbSNP
rs562946765 1954 dbSNP
rs1476461584 1955 dbSNP
rs966886160 1955 dbSNP
rs1022520929 1959 dbSNP
rs924955404 1961 dbSNP
rs958998977 1961 dbSNP
rs969620493 1963 dbSNP
rs1002891867 1966 dbSNP
rs917865739 1969 dbSNP
rs1035181422 1980 dbSNP
rs1274381961 1981 dbSNP
rs369491585 1989 dbSNP
rs1359334700 1990 dbSNP
rs961173181 1991 dbSNP
rs982862837 1992 dbSNP
rs748793480 1993 dbSNP
rs533045212 1994 dbSNP
rs907674542 1994 dbSNP
rs1177053026 2000 dbSNP
rs974035010 2007 dbSNP
rs1463834347 2008 dbSNP
rs942120481 2017 dbSNP
rs1172520271 2019 dbSNP
rs551295291 2030 dbSNP
rs16855615 2039 dbSNP
rs1444652817 2050 dbSNP
rs527502614 2056 dbSNP
rs16855616 2061 dbSNP
rs1366994666 2069 dbSNP
rs1189819768 2075 dbSNP
rs184272363 2080 dbSNP
rs751037927 2084 dbSNP
rs911702252 2085 dbSNP
rs1316640232 2090 dbSNP
rs1256810880 2104 dbSNP
rs944557297 2104 dbSNP
rs1218367053 2106 dbSNP
rs865879913 2112 dbSNP
rs1298805987 2115 dbSNP
rs1259140284 2118 dbSNP
rs1385999416 2121 dbSNP
rs1051760218 2131 dbSNP
rs1307662320 2131 dbSNP
rs1439859492 2137 dbSNP
rs1399487863 2140 dbSNP
rs1170019889 2154 dbSNP
rs1470371987 2166 dbSNP
rs1174302251 2169 dbSNP
rs1431697082 2169 dbSNP
rs1206175585 2174 dbSNP
rs1432821510 2176 dbSNP
rs1052146301 2177 dbSNP
rs892228426 2184 dbSNP
rs1179338811 2198 dbSNP
rs1456790575 2201 dbSNP
rs1238149014 2215 dbSNP
rs890742345 2223 dbSNP
rs1462314173 2225 dbSNP
rs567256352 2227 dbSNP
rs1010695030 2234 dbSNP
rs1043394498 2235 dbSNP
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rs1270909935 2241 dbSNP
rs1002430710 2242 dbSNP
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rs1317158866 2277 dbSNP
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rs1376030671 2304 dbSNP
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rs985624077 4547 dbSNP
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rs1275458025 4563 dbSNP
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rs965427785 4565 dbSNP
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rs1205931526 4619 dbSNP
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rs1054267295 4646 dbSNP
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rs528376183 4655 dbSNP
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rs1352142369 4670 dbSNP
rs1037451491 4677 dbSNP
rs1237832172 4687 dbSNP
rs541703716 4689 dbSNP
rs1340741073 4690 dbSNP
rs926155371 4691 dbSNP
rs1412768436 4700 dbSNP
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rs897117983 4706 dbSNP
rs996162073 4708 dbSNP
rs1027276497 4720 dbSNP
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rs1420432187 4727 dbSNP
rs547549140 4731 dbSNP
rs561988006 4734 dbSNP
rs1190503329 4735 dbSNP
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rs1161678026 4739 dbSNP
rs1257274709 4741 dbSNP
rs1007091937 4744 dbSNP
rs778498234 4746 dbSNP
rs529710931 4750 dbSNP
rs1305469408 4758 dbSNP
rs1343993810 4763 dbSNP
rs181199141 4775 dbSNP
rs1289844614 4778 dbSNP
rs1362133510 4789 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuGGAGGAUA----CGAUUCuugg 5'
             :|| | ||    ||||||    
Target 5' auuUCUACAAUUGCAGCUAAG---- 3'
 		12 - 32
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000295238.6 | 3UTR | CAAAACUCAGUAUUUCUACAAUUGCAGCUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.931 0 0.929 0 7 Click to see details
STAD 0.927 0 0.714 0.06 6 Click to see details
BRCA -0.74 0.02 -0.690 0.03 8 Click to see details
THCA -0.398 0.08 -0.569 0.02 14 Click to see details
PAAD 0.94 0.11 1.000 0.5 3 Click to see details
UCEC -0.445 0.12 -0.683 0.02 9 Click to see details
KIRP 0.62 0.13 0.500 0.2 5 Click to see details
LIHC 0.168 0.28 0.226 0.22 14 Click to see details
KIRC 0.24 0.28 0.048 0.46 8 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
HNSC 0.154 0.39 -0.429 0.2 6 Click to see details
62 hsa-miR-2116-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080547 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT135054 ADSS adenylosuccinate synthase 2 4
MIRT147317 KPNA2 karyopherin subunit alpha 2 2 4
MIRT154323 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT326799 SYAP1 synapse associated protein 1 2 2
MIRT357963 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384296 GOLT1B golgi transport 1B 2 2
MIRT442316 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443785 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446868 NBPF3 NBPF member 3 2 2
MIRT447647 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448470 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449121 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450245 TRIM66 tripartite motif containing 66 2 2
MIRT450270 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450688 RPN2 ribophorin II 2 2
MIRT481123 AZIN1 antizyme inhibitor 1 2 4
MIRT497207 CDH7 cadherin 7 2 4
MIRT502956 CCNT2 cyclin T2 2 2
MIRT509226 KIF14 kinesin family member 14 2 6
MIRT515395 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525559 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525608 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533254 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535782 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535803 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT543211 TMEM117 transmembrane protein 117 2 2
MIRT552792 YAF2 YY1 associated factor 2 2 2
MIRT553947 STAMBP STAM binding protein 2 2
MIRT556217 MB21D2 Mab-21 domain containing 2 2 2
MIRT566351 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT568429 GDNF glial cell derived neurotrophic factor 2 2
MIRT568521 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT573359 PDE3A phosphodiesterase 3A 2 2
MIRT574653 LMAN2 lectin, mannose binding 2 2 2
MIRT608172 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610692 FAM89A family with sequence similarity 89 member A 2 2
MIRT618459 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT622281 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624615 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631041 TAS2R30 taste 2 receptor member 30 2 2
MIRT638335 RCAN1 regulator of calcineurin 1 2 2
MIRT641630 KIAA1244 ARFGEF family member 3 1 1
MIRT649117 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652246 TPI1 triosephosphate isomerase 1 2 2
MIRT659865 CAPRIN1 cell cycle associated protein 1 2 4
MIRT669219 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682585 CPA4 carboxypeptidase A4 2 2
MIRT690129 EPHX2 epoxide hydrolase 2 2 2
MIRT699793 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT699991 RPS24 ribosomal protein S24 2 2
MIRT710376 LMBR1 limb development membrane protein 1 2 2
MIRT710412 YTHDC1 YTH domain containing 1 2 2
MIRT710574 TNPO1 transportin 1 2 2
MIRT712045 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT713292 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT718211 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718809 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719341 VGLL4 vestigial like family member 4 2 2
MIRT720841 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT724076 NCKAP1L NCK associated protein 1 like 2 2
MIRT724602 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-2116 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-2116-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2116-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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