pre-miRNA Information | |
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pre-miRNA | hsa-mir-3119-1 |
Genomic Coordinates | chr1: 170151378 - 170151462 |
Description | Homo sapiens miR-3119-1 stem-loop |
Comment | None |
RNA Secondary Structure | |
pre-miRNA | hsa-mir-3119-2 |
Genomic Coordinates | chr1: 170151378 - 170151462 |
Description | Homo sapiens miR-3119-2 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-3119 | ||||||||||||||||||||||||||||||
Sequence | 9| UGGCUUUUAACUUUGAUGGC |28 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZSCAN25 | ||||||||||||||||||||
Synonyms | ZNF498 | ||||||||||||||||||||
Description | zinc finger and SCAN domain containing 25 | ||||||||||||||||||||
Transcript | NM_145115 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZSCAN25 | |||||||||||||||||||||
3'UTR of ZSCAN25 (miRNA target sites are highlighted) |
>ZSCAN25|NM_145115|3'UTR 1 GCATAGCAGGTGGCAGGCAGCACCATCATTCATCTTTCTCACTGCAGGGCCTTGCGGGGTGCAAGGTGATGGCTGCAGGA 81 AAGCACTGGTCCCATCGCCTTCCCACCCATTCGCCAACGCGGGAAAGGCAAGGCCTGGCTTACTTAGAGCTTCCAGAGAG 161 CATAGCTGCTTCCATCTCTTACCCAAGTGGTGCTAAACAATTTTTCTTCCAATGTTTGAGGGAAGCAGTCTCCTGCGGTT 241 CAGTTCAGGCTGAGATTTTCTCCTTCAGTGGACTGTCTGTGTCCCCCTGCCGAACAAAGCTGGGAGTAAAGGCAAAACCT 321 TGACACGTGTTGGTAGCTGGGACCTCATCTTCCTGAGGGCTCTGTCTTGCCTGCAGGGTCATAGCTCAGACTCTTCCCCC 401 ACCCCCTCTCTTTTCCATTGAACAAACATTTATTGAACATCCTCTGAGCACCTGGCCGTGGGAATGCCGTGGTGAATGAG 481 AGACTAGACGTGATGCCTCTGGGGGTTGTGCGTTGGGGATGCATGCGACAGCCCATGACCCGAGGCATTCTCAGGGTATC 561 TGTGCTGTGTGCCCGTGAGAACATCTTCCCATGACCACTCCTGCCCTCCTGCCCCGTGCTGGATCTTCCCTCCCCAGCTG 641 GGATCTGCTCCCAGGCAACTGTGTGAATTTTACATTATTTGGAGCCTCATCTGTGTCAGGCTATAACATTCTATCCTCAT 721 CTGTAAAACTTCCCCGTCCATTATTCCTTGCACTATAACAACTGTCAACACACCAACTATTAGGAAGTTAGTATTTTGCT 801 ATTGATCACTGAATAAACATCAGAGTATTTTAAAAAACAGTTCTCTAGAAAGAACTGTTATAATTAAAATGAGTCTGAAA 881 GATGAACTCTAGTATTAATGCCCTATATTTGATGGCACTTTATAGTTCATAAAATTAATTTCACCCCATTCTCATTGGAC 961 CCATTTCCCAAGTATTTATTGAGGCCCTGTAACAAACATGTCAGGAACTCTTCTGGGTGCTTGAGACACATCCATGAATA 1041 AAATAGGGGGAGAAGCTGTTGACCTCGTAGAGCTTATGTCTCGTGGATGTACCTGATCTTCAGAACCCGTGGATATTCCT 1121 GCAAATCCTCTGGGCCTGTATTCATTGCTTTGTCAGCATCTTGCCCTGAAATGCATTTGTCACCTACCTCTTGTTACTAA 1201 ATGGTCTCTGCCCTCCAGACCCTTGTCATCCAAGGCACTAGGGGTCCTGGACACCCACTGGGGATGATGAGCTGGTAGCG 1281 ACCTGTTTTGCATGAGTGCCAAGTCAGGAAAAATAAAGATATTTGTAGGCATTAAAAAAAAATACATTTCTTTAAAAATG 1361 AGAAGATGCAATATTTGTAAACTGTTGAAGCTTCCTTATTGTGCCATCACTTAAGGGTTTCATTTCTGTTTAAAGTTCTG 1441 GAAGCTGCATAACTAGCGTGGACTGACTGCTGTGTCATTGTGCTGTGCCTTTGAACCCTGGCTGAGTGAGTGAGTTTGTC 1521 CTTTGTTGATAGTGTCCTATAATTGCAAAATGTGGTTTGTCTTCTGATGCCTCTTAATACCAGATTCTTTTACTGAGATT 1601 TTTTTTTTTCATTTTCCATTGTAAATAAGGTAAATGGTAATGACTAACACAAAGCTGTATTACTCAGCCCACTTTGAAAC 1681 GTGGTTTTATCACCTGTTCTTGTTAGGCAGCATGGTGTCTAATTTTGGCTTAGCAAATGACGCTCCTTGGTCTTCCTGGC 1761 TCATTAGCTGTGCCCACGAGGCTGCACTGACTGGGTCGTAAATGTATCTGAGATGTCCACACGGGGCTGCTGCTGCTCCT 1841 CTGTAATACTGAGGTCCACATGCAAAATCAGCTTTTTTTCCCCCGTAATTATCAGAGCAGCTAGGCAGGGCTGACAGCCA 1921 GGCAGACTCAGTGGGAGGCTTCTGGCCTGAGTGTGGCCTTCCCCAGAGGGTGGTTTTCCAAAGGCAGGTGGGGACTGGGG 2001 AGGCCTCGGGGGGCTGCTTGTCATTACCTGAATCACAGATGCTCTTTTGTCATACACAGCCAGCATTCCTCTGGGTTTCA 2081 GCAAGTTGGCATATCTTAAGCTTCAGAAGGAGCTGGGCCTTGCTGACTTTCCTATCTGGCCTCTTCCCTATCTCCTGTGG 2161 GGCCAAGAGCTTAGGACAGTGTCTCAGAAAAGCCTCTAAGTAGGGGGTTTTTCCCATGGGATTGTGGTAGTCTGATTTTT 2241 CATATCTATTCAAATGTTAAGAAATATTTTGTTTTCTGTATTTTTCTATTCTTTAGAAATTTTTTTATAATAGATAATTT 2321 CAAACCTATATAAATAAATCCTTATGTATTTATCATTTGACTTTATTATAAACTCATAATCAATCTTAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 221785.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065668 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_7 |
Location of target site | ENST00000394152.2 | 3UTR | UCUCAGAAAAGCCUCUAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000394152.2 | 3UTR | UCUCAGAAAAGCCUCUAAGUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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67 hsa-miR-3119 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT130164 | TXNIP | thioredoxin interacting protein | 2 | 4 | ||||||||
MIRT364023 | SDCBP | syndecan binding protein | 2 | 2 | ||||||||
MIRT383920 | BTG2 | BTG anti-proliferation factor 2 | 2 | 2 | ||||||||
MIRT397609 | RACGAP1 | Rac GTPase activating protein 1 | 2 | 2 | ||||||||
MIRT404072 | ZBTB21 | zinc finger and BTB domain containing 21 | 2 | 2 | ||||||||
MIRT443202 | ECHDC3 | enoyl-CoA hydratase domain containing 3 | 2 | 2 | ||||||||
MIRT446469 | THUMPD3 | THUMP domain containing 3 | 2 | 2 | ||||||||
MIRT446489 | PRELP | proline and arginine rich end leucine rich repeat protein | 2 | 2 | ||||||||
MIRT446849 | FIBIN | fin bud initiation factor homolog (zebrafish) | 2 | 2 | ||||||||
MIRT463282 | ZFX | zinc finger protein, X-linked | 2 | 4 | ||||||||
MIRT478441 | DAZAP2 | DAZ associated protein 2 | 2 | 2 | ||||||||
MIRT480447 | C16orf72 | chromosome 16 open reading frame 72 | 2 | 2 | ||||||||
MIRT480632 | BTBD3 | BTB domain containing 3 | 2 | 6 | ||||||||
MIRT487460 | ANKRD42 | ankyrin repeat domain 42 | 2 | 2 | ||||||||
MIRT487497 | IL1F10 | interleukin 1 family member 10 | 2 | 4 | ||||||||
MIRT491967 | USP37 | ubiquitin specific peptidase 37 | 2 | 2 | ||||||||
MIRT495620 | PPP1R1C | protein phosphatase 1 regulatory inhibitor subunit 1C | 2 | 2 | ||||||||
MIRT496151 | RPS15A | ribosomal protein S15a | 2 | 2 | ||||||||
MIRT498042 | SNX5 | sorting nexin 5 | 2 | 6 | ||||||||
MIRT500546 | XBP1P1 | X-box binding protein 1 pseudogene 1 | 2 | 8 | ||||||||
MIRT503902 | ZSCAN25 | zinc finger and SCAN domain containing 25 | 2 | 2 | ||||||||
MIRT513157 | BIRC5 | baculoviral IAP repeat containing 5 | 2 | 6 | ||||||||
MIRT519070 | KCNK6 | potassium two pore domain channel subfamily K member 6 | 2 | 2 | ||||||||
MIRT519741 | ZNF394 | zinc finger protein 394 | 2 | 4 | ||||||||
MIRT522733 | LRP8 | LDL receptor related protein 8 | 2 | 4 | ||||||||
MIRT539402 | ADIPOR2 | adiponectin receptor 2 | 2 | 2 | ||||||||
MIRT551660 | KIAA1143 | KIAA1143 | 2 | 4 | ||||||||
MIRT559131 | BTG3 | BTG anti-proliferation factor 3 | 2 | 4 | ||||||||
MIRT559307 | ATXN1 | ataxin 1 | 2 | 2 | ||||||||
MIRT559515 | ARHGEF26 | Rho guanine nucleotide exchange factor 26 | 2 | 2 | ||||||||
MIRT560771 | RRP7A | ribosomal RNA processing 7 homolog A | 2 | 2 | ||||||||
MIRT562210 | HMGB2 | high mobility group box 2 | 2 | 2 | ||||||||
MIRT562734 | ZNF468 | zinc finger protein 468 | 2 | 2 | ||||||||
MIRT563070 | EMC8 | ER membrane protein complex subunit 8 | 2 | 2 | ||||||||
MIRT563731 | ZNF107 | zinc finger protein 107 | 2 | 4 | ||||||||
MIRT576719 | Wars | tryptophanyl-tRNA synthetase | 2 | 2 | ||||||||
MIRT612872 | IGFBP5 | insulin like growth factor binding protein 5 | 2 | 4 | ||||||||
MIRT613214 | CCDC85C | coiled-coil domain containing 85C | 2 | 4 | ||||||||
MIRT613591 | THSD7A | thrombospondin type 1 domain containing 7A | 2 | 2 | ||||||||
MIRT614332 | NANOS1 | nanos C2HC-type zinc finger 1 | 2 | 4 | ||||||||
MIRT614929 | MARCH3 | membrane associated ring-CH-type finger 3 | 2 | 2 | ||||||||
MIRT616257 | KANK4 | KN motif and ankyrin repeat domains 4 | 2 | 2 | ||||||||
MIRT617087 | FPR1 | formyl peptide receptor 1 | 2 | 2 | ||||||||
MIRT617167 | SLC16A5 | solute carrier family 16 member 5 | 2 | 2 | ||||||||
MIRT620350 | WDR75 | WD repeat domain 75 | 2 | 2 | ||||||||
MIRT621041 | SOX30 | SRY-box 30 | 2 | 2 | ||||||||
MIRT625936 | SCYL3 | SCY1 like pseudokinase 3 | 2 | 2 | ||||||||
MIRT636872 | BCORL1 | BCL6 corepressor like 1 | 2 | 2 | ||||||||
MIRT637019 | CLASP1 | cytoplasmic linker associated protein 1 | 2 | 2 | ||||||||
MIRT637299 | ACTN2 | actinin alpha 2 | 2 | 2 | ||||||||
MIRT639734 | MAP2K2 | mitogen-activated protein kinase kinase 2 | 2 | 2 | ||||||||
MIRT640811 | ZMAT1 | zinc finger matrin-type 1 | 2 | 2 | ||||||||
MIRT642879 | SAMD1 | sterile alpha motif domain containing 1 | 2 | 2 | ||||||||
MIRT648116 | ADAT1 | adenosine deaminase, tRNA specific 1 | 2 | 2 | ||||||||
MIRT655769 | NPTX1 | neuronal pentraxin 1 | 2 | 2 | ||||||||
MIRT655801 | NOVA2 | NOVA alternative splicing regulator 2 | 2 | 2 | ||||||||
MIRT659142 | DDR2 | discoidin domain receptor tyrosine kinase 2 | 2 | 2 | ||||||||
MIRT660327 | BCL11B | B-cell CLL/lymphoma 11B | 2 | 2 | ||||||||
MIRT662150 | IPO11 | importin 11 | 2 | 2 | ||||||||
MIRT664741 | METTL16 | methyltransferase like 16 | 2 | 2 | ||||||||
MIRT670134 | HOXD12 | homeobox D12 | 2 | 2 | ||||||||
MIRT679027 | ZNF419 | zinc finger protein 419 | 2 | 2 | ||||||||
MIRT695596 | TMEM199 | transmembrane protein 199 | 2 | 2 | ||||||||
MIRT703345 | GATAD2B | GATA zinc finger domain containing 2B | 2 | 2 | ||||||||
MIRT704097 | DST | dystonin | 2 | 2 | ||||||||
MIRT711833 | AMOTL2 | angiomotin like 2 | 2 | 2 | ||||||||
MIRT715820 | ZNF598 | zinc finger protein 598 | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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