pre-miRNA Information | |
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pre-miRNA | hsa-mir-4486 |
Genomic Coordinates | chr11: 19575310 - 19575372 |
Description | Homo sapiens miR-4486 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-4486 | ||||||||||||
Sequence | 5| GCUGGGCGAGGCUGGCA |21 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | Illumina | ||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TOMM5 | ||||||||||||||||||||
Synonyms | C9orf105, Tom5, bA613M10.3 | ||||||||||||||||||||
Description | translocase of outer mitochondrial membrane 5 | ||||||||||||||||||||
Transcript | NM_001134484 | ||||||||||||||||||||
Other Transcripts | NM_001001790 , NM_001134485 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TOMM5 | |||||||||||||||||||||
3'UTR of TOMM5 (miRNA target sites are highlighted) |
>TOMM5|NM_001134484|3'UTR 1 GCTCCATTTATCTTAAAGAAATTGGACAGCATATGAAGACAGGACATCACATATGAATGCACGATATGAAGAGCCTGGTT 81 ACAGTTTCGACTCCTCTCTGCAAGTGAATAGGCCCAGAAAGGTGTAAGAGACTCTTTGAATGGACATAAAATTCTGCTTG 161 TTAAGAACAAGTTTGGCTCTGGTAACTGACCTTCAAAGCTAAAATATAAAACTATTTGGGAAGTATGAAACGATGTCTCG 241 TGATCTGGTGTACCCTTATCCCTGTGACGTTTGGCCTCTGACAATACTGGTATAATTGTAAATAATGTCAAACTCCGTTT 321 TCTAGCAAGTATTAAGGGAGCTGTGTCTGAAATGGCACTGTCTTGTCAGTCATTTCTGTTTACCTTTTTCTTCTGCCCAG 401 AGTGTATTTGTGAAGAGTCTCTTATATTATGTTTTGTGGAAATCAGCACACAACCACAATGACATTTAAGCACAGGATCA 481 TTATTAGTCTATGTTTTTAATAAACATATCAATTAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 401505.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM4903825 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / PID14_NS |
Location of target site | NM_001134485 | 3UTR | AGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161237 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903829 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Human neurons / CTLTD_shCTL_a |
Location of target site | NM_001001790 | 3UTR | CUUUUUCUUCUGCCC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161238 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_001134485 | 3UTR | GACAGGACAUCACAUAUGAAUGCACGAUAUGAAGAGCCUGGUUACAGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM4903834 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_b |
Location of target site | NM_001134485 | 3UTR | ACAGGACAUCACAUAUGAAUGCACGAUAUGAAGAGCCUGGUUACAGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM4903835 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_c |
Location of target site | NM_001134485 | 3UTR | GACAGGACAUCACAUAUGAAUGCACGAUAUGAAGAGCCUGGUUACAGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM4903836 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_a |
Location of target site | NM_001134485 | 3UTR | GACAGGACAUCACAUAUGAAUGCACGAUAUGAAGAGCCUGGUUACAGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM4903837 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_b |
Location of target site | NM_001134485 | 3UTR | AGGACAUCACAUAUGAAUGCACGAUAUGAAGAGCCUGGUUACAGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 8 for dataset GSM4903838 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_001134485 | 3UTR | GACAGGACAUCACAUAUGAAUGCACGAUAUGAAGAGCCUGGUUACAGUUUCGACUCCUCUCUGCAAGUGAAUAGGCCCAGAAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 9 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000377773.5 | 3UTR | UCAUUUCUGUUUACCUUUUUCUUCUGCCCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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108 hsa-miR-4486 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT254654 | NF2 | neurofibromin 2 | 2 | 2 | ||||||||
MIRT458684 | MRI1 | methylthioribose-1-phosphate isomerase 1 | 2 | 2 | ||||||||
MIRT470845 | PLXND1 | plexin D1 | 2 | 2 | ||||||||
MIRT493011 | NANOS1 | nanos C2HC-type zinc finger 1 | 2 | 2 | ||||||||
MIRT497264 | GRK6 | G protein-coupled receptor kinase 6 | 2 | 2 | ||||||||
MIRT497675 | SYNGR1 | synaptogyrin 1 | 2 | 2 | ||||||||
MIRT498219 | TLN2 | talin 2 | 2 | 2 | ||||||||
MIRT498310 | BCL11B | B-cell CLL/lymphoma 11B | 2 | 2 | ||||||||
MIRT504048 | TOMM5 | translocase of outer mitochondrial membrane 5 | 2 | 2 | ||||||||
MIRT519959 | ZCCHC8 | zinc finger CCHC-type containing 8 | 2 | 2 | ||||||||
MIRT531521 | NOM1 | nucleolar protein with MIF4G domain 1 | 2 | 2 | ||||||||
MIRT533144 | WNT10A | Wnt family member 10A | 2 | 2 | ||||||||
MIRT533541 | TPR | translocated promoter region, nuclear basket protein | 2 | 2 | ||||||||
MIRT533681 | TMEM86A | transmembrane protein 86A | 2 | 2 | ||||||||
MIRT540321 | PIGR | polymeric immunoglobulin receptor | 2 | 2 | ||||||||
MIRT540719 | GUF1 | GUF1 homolog, GTPase | 2 | 2 | ||||||||
MIRT541566 | ZNF43 | zinc finger protein 43 | 2 | 4 | ||||||||
MIRT541787 | TBCCD1 | TBCC domain containing 1 | 2 | 2 | ||||||||
MIRT541925 | ORC1 | origin recognition complex subunit 1 | 2 | 4 | ||||||||
MIRT542232 | FUT9 | fucosyltransferase 9 | 2 | 2 | ||||||||
MIRT542285 | POLR3K | RNA polymerase III subunit K | 2 | 2 | ||||||||
MIRT542299 | QTRTD1 | queuine tRNA-ribosyltransferase accessory subunit 2 | 2 | 4 | ||||||||
MIRT542368 | PAICS | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase | 2 | 2 | ||||||||
MIRT542441 | C3 | complement C3 | 2 | 4 | ||||||||
MIRT542475 | APOC3 | apolipoprotein C3 | 2 | 2 | ||||||||
MIRT542535 | MRPS10 | mitochondrial ribosomal protein S10 | 2 | 2 | ||||||||
MIRT542640 | TIMM8A | translocase of inner mitochondrial membrane 8A | 2 | 2 | ||||||||
MIRT542788 | PLEKHA3 | pleckstrin homology domain containing A3 | 2 | 2 | ||||||||
MIRT552104 | PPP1R1A | protein phosphatase 1 regulatory inhibitor subunit 1A | 2 | 2 | ||||||||
MIRT564913 | YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | 2 | 2 | ||||||||
MIRT568606 | ACVR2A | activin A receptor type 2A | 2 | 2 | ||||||||
MIRT607389 | LANCL3 | LanC like 3 | 2 | 2 | ||||||||
MIRT607451 | ZNF543 | zinc finger protein 543 | 2 | 2 | ||||||||
MIRT610058 | MYBPC1 | myosin binding protein C, slow type | 2 | 2 | ||||||||
MIRT610793 | KLK2 | kallikrein related peptidase 2 | 2 | 2 | ||||||||
MIRT617176 | GOSR2 | golgi SNAP receptor complex member 2 | 2 | 2 | ||||||||
MIRT620579 | WBSCR27 | methyltransferase like 27 | 2 | 4 | ||||||||
MIRT622085 | SRPX2 | sushi repeat containing protein, X-linked 2 | 2 | 2 | ||||||||
MIRT622542 | PXMP4 | peroxisomal membrane protein 4 | 2 | 2 | ||||||||
MIRT630009 | PDE6B | phosphodiesterase 6B | 2 | 2 | ||||||||
MIRT631813 | PTDSS2 | phosphatidylserine synthase 2 | 2 | 2 | ||||||||
MIRT632721 | MSANTD4 | Myb/SANT DNA binding domain containing 4 with coiled-coils | 2 | 2 | ||||||||
MIRT632757 | MED28 | mediator complex subunit 28 | 2 | 2 | ||||||||
MIRT634821 | ASB6 | ankyrin repeat and SOCS box containing 6 | 2 | 2 | ||||||||
MIRT635255 | FBXL20 | F-box and leucine rich repeat protein 20 | 2 | 2 | ||||||||
MIRT637082 | SELPLG | selectin P ligand | 2 | 2 | ||||||||
MIRT637357 | ZNF460 | zinc finger protein 460 | 2 | 2 | ||||||||
MIRT637472 | DEFB105B | defensin beta 105B | 2 | 4 | ||||||||
MIRT637504 | DEFB105A | defensin beta 105A | 2 | 4 | ||||||||
MIRT639022 | AAK1 | AP2 associated kinase 1 | 2 | 2 | ||||||||
MIRT641012 | ANKFY1 | ankyrin repeat and FYVE domain containing 1 | 2 | 2 | ||||||||
MIRT642170 | HEBP2 | heme binding protein 2 | 2 | 2 | ||||||||
MIRT648977 | ACAD8 | acyl-CoA dehydrogenase family member 8 | 2 | 2 | ||||||||
MIRT650515 | UFM1 | ubiquitin fold modifier 1 | 2 | 2 | ||||||||
MIRT650949 | INMT | indolethylamine N-methyltransferase | 2 | 2 | ||||||||
MIRT658354 | FAM65B | RHO family interacting cell polarization regulator 2 | 2 | 2 | ||||||||
MIRT660736 | ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 2 | 2 | ||||||||
MIRT662191 | MEI1 | meiotic double-stranded break formation protein 1 | 2 | 2 | ||||||||
MIRT663045 | SLC16A4 | solute carrier family 16 member 4 | 2 | 2 | ||||||||
MIRT664811 | IRAK3 | interleukin 1 receptor associated kinase 3 | 2 | 2 | ||||||||
MIRT665161 | SF3A1 | splicing factor 3a subunit 1 | 2 | 4 | ||||||||
MIRT665346 | YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 2 | 2 | ||||||||
MIRT666493 | SBNO1 | strawberry notch homolog 1 | 2 | 2 | ||||||||
MIRT666545 | RNF115 | ring finger protein 115 | 2 | 2 | ||||||||
MIRT669351 | BMP3 | bone morphogenetic protein 3 | 2 | 2 | ||||||||
MIRT669904 | KIAA0754 | KIAA0754 | 2 | 4 | ||||||||
MIRT670323 | CEP57L1 | centrosomal protein 57 like 1 | 2 | 2 | ||||||||
MIRT670430 | ELP2 | elongator acetyltransferase complex subunit 2 | 2 | 2 | ||||||||
MIRT670672 | KIAA1551 | KIAA1551 | 2 | 2 | ||||||||
MIRT670746 | HOOK3 | hook microtubule tethering protein 3 | 2 | 2 | ||||||||
MIRT670998 | PTGIS | prostaglandin I2 synthase | 2 | 2 | ||||||||
MIRT671290 | RPL37A | ribosomal protein L37a | 2 | 2 | ||||||||
MIRT671469 | AGPAT6 | glycerol-3-phosphate acyltransferase 4 | 2 | 2 | ||||||||
MIRT671833 | STIL | STIL, centriolar assembly protein | 2 | 2 | ||||||||
MIRT673006 | TAF1 | TATA-box binding protein associated factor 1 | 2 | 2 | ||||||||
MIRT675881 | CSTF1 | cleavage stimulation factor subunit 1 | 2 | 2 | ||||||||
MIRT678625 | OLFML2A | olfactomedin like 2A | 2 | 2 | ||||||||
MIRT678790 | NUPL2 | nucleoporin like 2 | 2 | 2 | ||||||||
MIRT679560 | LIN9 | lin-9 DREAM MuvB core complex component | 2 | 2 | ||||||||
MIRT681032 | AAED1 | AhpC/TSA antioxidant enzyme domain containing 1 | 2 | 2 | ||||||||
MIRT682480 | LIX1L | limb and CNS expressed 1 like | 2 | 2 | ||||||||
MIRT682758 | MDM2 | MDM2 proto-oncogene | 2 | 2 | ||||||||
MIRT682810 | TMCO1 | transmembrane and coiled-coil domains 1 | 2 | 2 | ||||||||
MIRT682867 | C9orf156 | tRNA methyltransferase O | 2 | 2 | ||||||||
MIRT689233 | RPS19 | ribosomal protein S19 | 2 | 2 | ||||||||
MIRT689305 | C5AR2 | complement component 5a receptor 2 | 2 | 2 | ||||||||
MIRT689363 | ZNF101 | zinc finger protein 101 | 2 | 2 | ||||||||
MIRT689629 | NAA30 | N(alpha)-acetyltransferase 30, NatC catalytic subunit | 2 | 2 | ||||||||
MIRT689654 | RBM23 | RNA binding motif protein 23 | 2 | 2 | ||||||||
MIRT690148 | PPIL6 | peptidylprolyl isomerase like 6 | 2 | 2 | ||||||||
MIRT691407 | DNA2 | DNA replication helicase/nuclease 2 | 2 | 2 | ||||||||
MIRT691847 | OSCAR | osteoclast associated, immunoglobulin-like receptor | 2 | 2 | ||||||||
MIRT692234 | ALDH1B1 | aldehyde dehydrogenase 1 family member B1 | 2 | 2 | ||||||||
MIRT694320 | NLRP9 | NLR family pyrin domain containing 9 | 2 | 2 | ||||||||
MIRT694365 | CHST6 | carbohydrate sulfotransferase 6 | 2 | 2 | ||||||||
MIRT696215 | LYZ | lysozyme | 2 | 2 | ||||||||
MIRT697230 | ZYG11A | zyg-11 family member A, cell cycle regulator | 2 | 2 | ||||||||
MIRT700487 | PTPRF | protein tyrosine phosphatase, receptor type F | 2 | 2 | ||||||||
MIRT700612 | PRKCA | protein kinase C alpha | 2 | 2 | ||||||||
MIRT702456 | KIAA1467 | family with sequence similarity 234 member B | 2 | 2 | ||||||||
MIRT702990 | HERPUD2 | HERPUD family member 2 | 2 | 2 | ||||||||
MIRT703998 | EIF5A2 | eukaryotic translation initiation factor 5A2 | 2 | 2 | ||||||||
MIRT704701 | CHRFAM7A | CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion | 2 | 2 | ||||||||
MIRT712481 | FSTL3 | follistatin like 3 | 2 | 2 | ||||||||
MIRT712781 | ZNF154 | zinc finger protein 154 | 2 | 2 | ||||||||
MIRT714369 | HP1BP3 | heterochromatin protein 1 binding protein 3 | 2 | 2 | ||||||||
MIRT722570 | C1orf95 | stum, mechanosensory transduction mediator homolog | 2 | 2 | ||||||||
MIRT722839 | C17orf102 | chromosome 17 open reading frame 102 | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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