pre-miRNA Information | |
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pre-miRNA | hsa-mir-6787 |
Genomic Coordinates | chr17: 82236668 - 82236728 |
Description | Homo sapiens miR-6787 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-6787-5p | ||||||||||||||||||||||||||||||||||||
Sequence | 6| UGGCGGGGGUAGAGCUGGCUGC |27 | ||||||||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||||||||
Experiments | Meta-analysis | ||||||||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | PDRG1 | ||||||||||||||||||||
Synonyms | C20orf126, PDRG | ||||||||||||||||||||
Description | p53 and DNA damage regulated 1 | ||||||||||||||||||||
Transcript | NM_030815 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on PDRG1 | |||||||||||||||||||||
3'UTR of PDRG1 (miRNA target sites are highlighted) |
>PDRG1|NM_030815|3'UTR 1 GACTCAAGAACCAAGATGGGGGACCAGCAACCCCCCAGGGTCATGGAGGACCCAGGACCCTCCAACCTTGACACCTGTAA 81 GGACAGGATCTGCCCTGTAAGGGGCCAGCCGTCAGGAATCTGGCCATGAAAACCTCTTTGTAGTGCTTGGCTACTCTGTG 161 ATGGCAGGAGGGAACCTTCAGCCTGTCTGGCTGCTGGACCTGGACACCAGGGCTCGGTGGACACAAGATCTATTGACGGG 241 CCTTGGTAGCCACCAGTGGGTGTGTGGGGCAGTGGCTGTGGGGGTGTAAGAATGACTGCAACAGGCACTTCCCAACAATG 321 GCCTGCTGTTCACATGGACCCTGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGTGGAGTGTCATTCCAGCATTCCTCTCAG 401 AAGGGAGAGAGGTTTTCAGGCTGGTGCCATGCGATTGGAATAAAGCAGGAGGCTCATGGGTGGTTGCTGAATGAAGAACA 481 GAATCTTGGTGCTTTGTGGCTCACCACAGCCATCTGTGGGGCAGGCACACACACCTCCCGCCAGCTCCAATTTTGCACTT 561 TTTCCCTGCTTGATTCCAAGAGTAGGTGCTGCCTAGCAGCCCTTCGTGGCCACTCTTTACTCAGGAGGGCCTTGCAGAGT 641 CCTGCACCAGGCCTGGGTGAGTGGATGCGCCTCTTACCATATGACACGTGTCAAGATGCCCTTCCGCCCCCTCTGAAAGT 721 GGGGCCCGGCCAGCACTGCTCGTTACTGTCTGCCTTCAGTGGTCTGAGGTCCCAGTATGAACTGCCGTGAAGTCAAAACT 801 CTTATGTGTTCATTAAGGGCTCAATAAATGTTAGCTGAATGAATGAATAGCAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 81572.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065669 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_8 |
Location of target site | ENST00000202017.4 | 3UTR | CCUCCCGCCAGCUCCAAUUUUGCACUUUUUCCCUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000202017.4 | 3UTR | CCAGCUCCAAUUUUGCACUUUUUCCCU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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90 hsa-miR-6787-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT449091 | XPO6 | exportin 6 | ![]() |
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2 | 2 | ||||||
MIRT449991 | PSMG1 | proteasome assembly chaperone 1 | ![]() |
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2 | 2 | ||||||
MIRT454608 | MYADM | myeloid associated differentiation marker | ![]() |
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2 | 2 | ||||||
MIRT456116 | VAV3 | vav guanine nucleotide exchange factor 3 | ![]() |
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2 | 6 | ||||||
MIRT457064 | TOR4A | torsin family 4 member A | ![]() |
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2 | 2 | ||||||
MIRT461023 | SDF4 | stromal cell derived factor 4 | ![]() |
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2 | 2 | ||||||
MIRT467197 | SPRY4 | sprouty RTK signaling antagonist 4 | ![]() |
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2 | 2 | ||||||
MIRT471711 | OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | ![]() |
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2 | 2 | ||||||
MIRT472566 | NACC1 | nucleus accumbens associated 1 | ![]() |
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2 | 2 | ||||||
MIRT476079 | GRB2 | growth factor receptor bound protein 2 | ![]() |
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2 | 2 | ||||||
MIRT480150 | CALR | calreticulin | ![]() |
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2 | 2 | ||||||
MIRT483027 | KHSRP | KH-type splicing regulatory protein | ![]() |
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2 | 4 | ||||||
MIRT483498 | STMN3 | stathmin 3 | ![]() |
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2 | 4 | ||||||
MIRT483728 | THSD4 | thrombospondin type 1 domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT484550 | BARHL1 | BarH like homeobox 1 | ![]() |
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2 | 6 | ||||||
MIRT484684 | PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | ![]() |
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2 | 2 | ||||||
MIRT486059 | CTDNEP1 | CTD nuclear envelope phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT486116 | INO80E | INO80 complex subunit E | ![]() |
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2 | 2 | ||||||
MIRT486313 | SIPA1 | signal-induced proliferation-associated 1 | ![]() |
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2 | 2 | ||||||
MIRT486525 | CLCN7 | chloride voltage-gated channel 7 | ![]() |
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2 | 2 | ||||||
MIRT486857 | DPF1 | double PHD fingers 1 | ![]() |
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2 | 2 | ||||||
MIRT487352 | PHF15 | jade family PHD finger 2 | ![]() |
1 | 1 | |||||||
MIRT487582 | FAM83H | family with sequence similarity 83 member H | ![]() |
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2 | 4 | ||||||
MIRT487792 | GPR20 | G protein-coupled receptor 20 | ![]() |
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2 | 4 | ||||||
MIRT488104 | POU3F1 | POU class 3 homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT488786 | POFUT2 | protein O-fucosyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT489361 | SYNGR1 | synaptogyrin 1 | ![]() |
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2 | 4 | ||||||
MIRT489387 | RAB11B | RAB11B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT489680 | SCAMP4 | secretory carrier membrane protein 4 | ![]() |
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2 | 2 | ||||||
MIRT489731 | GNAI2 | G protein subunit alpha i2 | ![]() |
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2 | 4 | ||||||
MIRT489750 | TACC3 | transforming acidic coiled-coil containing protein 3 | ![]() |
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2 | 2 | ||||||
MIRT490029 | PCSK4 | proprotein convertase subtilisin/kexin type 4 | ![]() |
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2 | 2 | ||||||
MIRT490379 | LHFPL3 | LHFPL tetraspan subfamily member 3 | ![]() |
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2 | 2 | ||||||
MIRT490580 | SLC47A1 | solute carrier family 47 member 1 | ![]() |
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2 | 2 | ||||||
MIRT490753 | SRCIN1 | SRC kinase signaling inhibitor 1 | ![]() |
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2 | 2 | ||||||
MIRT491187 | JUND | JunD proto-oncogene, AP-1 transcription factor subunit | ![]() |
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2 | 4 | ||||||
MIRT491301 | VGF | VGF nerve growth factor inducible | ![]() |
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2 | 2 | ||||||
MIRT491462 | HOXB8 | homeobox B8 | ![]() |
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2 | 2 | ||||||
MIRT491702 | PDZD4 | PDZ domain containing 4 | ![]() |
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2 | 2 | ||||||
MIRT491724 | RTN4R | reticulon 4 receptor | ![]() |
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2 | 2 | ||||||
MIRT491737 | SEMA3F | semaphorin 3F | ![]() |
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2 | 2 | ||||||
MIRT491984 | UNK | unkempt family zinc finger | ![]() |
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2 | 2 | ||||||
MIRT492844 | NRGN | neurogranin | ![]() |
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2 | 2 | ||||||
MIRT492936 | NEUROD2 | neuronal differentiation 2 | ![]() |
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2 | 4 | ||||||
MIRT493713 | H2AFX | H2A histone family member X | ![]() |
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2 | 2 | ||||||
MIRT494623 | ASB6 | ankyrin repeat and SOCS box containing 6 | ![]() |
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2 | 4 | ||||||
MIRT494703 | ARHGAP31 | Rho GTPase activating protein 31 | ![]() |
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2 | 2 | ||||||
MIRT495602 | NKX2-5 | NK2 homeobox 5 | ![]() |
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2 | 2 | ||||||
MIRT495750 | PDE4C | phosphodiesterase 4C | ![]() |
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2 | 4 | ||||||
MIRT500367 | ZNF385A | zinc finger protein 385A | ![]() |
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2 | 2 | ||||||
MIRT501161 | SLC10A7 | solute carrier family 10 member 7 | ![]() |
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2 | 6 | ||||||
MIRT501702 | PCGF3 | polycomb group ring finger 3 | ![]() |
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2 | 6 | ||||||
MIRT504922 | PDRG1 | p53 and DNA damage regulated 1 | ![]() |
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2 | 2 | ||||||
MIRT517945 | TRIM59 | tripartite motif containing 59 | ![]() |
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2 | 2 | ||||||
MIRT524212 | DDI2 | DNA damage inducible 1 homolog 2 | ![]() |
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2 | 6 | ||||||
MIRT531186 | SIGLEC12 | sialic acid binding Ig like lectin 12 (gene/pseudogene) | ![]() |
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2 | 2 | ||||||
MIRT531972 | C12orf49 | chromosome 12 open reading frame 49 | ![]() |
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2 | 2 | ||||||
MIRT558055 | EVI5L | ecotropic viral integration site 5 like | ![]() |
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2 | 2 | ||||||
MIRT560482 | LACE1 | AFG1 like ATPase | ![]() |
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2 | 2 | ||||||
MIRT563217 | FXN | frataxin | ![]() |
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2 | 2 | ||||||
MIRT569095 | FSCN1 | fascin actin-bundling protein 1 | ![]() |
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2 | 2 | ||||||
MIRT569522 | AP5Z1 | adaptor related protein complex 5 zeta 1 subunit | ![]() |
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2 | 2 | ||||||
MIRT569531 | CTTN | cortactin | ![]() |
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2 | 2 | ||||||
MIRT569848 | RGS5 | regulator of G protein signaling 5 | ![]() |
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2 | 2 | ||||||
MIRT570738 | ANKRD52 | ankyrin repeat domain 52 | ![]() |
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2 | 2 | ||||||
MIRT574140 | MARVELD1 | MARVEL domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT615994 | DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT628493 | ZNF556 | zinc finger protein 556 | ![]() |
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2 | 2 | ||||||
MIRT633451 | KLLN | killin, p53-regulated DNA replication inhibitor | ![]() |
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2 | 2 | ||||||
MIRT649054 | SLC1A2 | solute carrier family 1 member 2 | ![]() |
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2 | 2 | ||||||
MIRT649340 | HEXA | hexosaminidase subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT670226 | PTCHD1 | patched domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT670666 | KIAA1551 | KIAA1551 | ![]() |
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2 | 2 | ||||||
MIRT671452 | CDH7 | cadherin 7 | ![]() |
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2 | 2 | ||||||
MIRT671729 | ZNF451 | zinc finger protein 451 | ![]() |
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2 | 2 | ||||||
MIRT690285 | ZNF154 | zinc finger protein 154 | ![]() |
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2 | 2 | ||||||
MIRT700575 | PRSS22 | protease, serine 22 | ![]() |
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2 | 2 | ||||||
MIRT701411 | NKRF | NFKB repressing factor | ![]() |
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2 | 2 | ||||||
MIRT711877 | VASP | vasodilator stimulated phosphoprotein | ![]() |
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2 | 2 | ||||||
MIRT712082 | UNC13A | unc-13 homolog A | ![]() |
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2 | 2 | ||||||
MIRT712523 | CYTH2 | cytohesin 2 | ![]() |
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2 | 2 | ||||||
MIRT712751 | GMDS | GDP-mannose 4,6-dehydratase | ![]() |
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2 | 2 | ||||||
MIRT714681 | PRX | periaxin | ![]() |
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2 | 2 | ||||||
MIRT714718 | VPS8 | VPS8, CORVET complex subunit | ![]() |
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2 | 2 | ||||||
MIRT717508 | HRNR | hornerin | ![]() |
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2 | 2 | ||||||
MIRT717650 | THBS2 | thrombospondin 2 | ![]() |
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2 | 2 | ||||||
MIRT719592 | PIAS4 | protein inhibitor of activated STAT 4 | ![]() |
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2 | 2 | ||||||
MIRT720521 | PTGR2 | prostaglandin reductase 2 | ![]() |
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2 | 2 | ||||||
MIRT721295 | C3orf36 | chromosome 3 open reading frame 36 | ![]() |
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2 | 2 | ||||||
MIRT724922 | VPS18 | VPS18, CORVET/HOPS core subunit | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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