pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF644   
Synonyms BM-005, MYP21, NatF, ZEP-2
Description zinc finger protein 644
Transcript NM_016620   
Other Transcripts NM_032186 , NM_201269   
Expression
Putative miRNA Targets on ZNF644
3'UTR of ZNF644
(miRNA target sites are highlighted)
>ZNF644|NM_016620|3'UTR
   1 AACCAGGAAACCTTTTAAATAGCCAGTTTGAATTGGATGTAAATTTGAAATTCTTTTTTTTTAAGCCACATTAAATTATC
  81 TGTTTATAAATACTAAAGCAGGAAAATGGGGGGAAAGTGAATTACAGTGACATCAGAGCAAATTGAATACTTAAAACAGT
 161 AAGTAGTCTATATATTTTATATAGGGTGGAAGATGTGTTTTTAAGGTTTATGAAGTTTTGTTGGTTAACTGTGTTCACTC
 241 AGTAAAAGAGCAGTACATGTAAGCAGCCATTAATAAACTGTTGCACATGGATACTTATAGACAGACTTATTGGACAATTA
 321 TGTTTTTTGCAGTGTTACCAGAATCAAGGCTCTGTTTATTCCCCACAAGACTTGCATAGAAAAATAAGATATTATATTTT
 401 GTTTGTATGTATTTAGTGTTTTGTATAATACCAAGAACCGCTGACTAAATTTACTCAAATTAGGGCATTAAATATCATGT
 481 ACTTCATAGTTTGAGACTGTTCACTCAAATAGGGCAGAGTACTATTCTATCTAGATGTGTAAGTGTTTTTTTTAAAATCA
 561 CATGGAACGGTTTTTTTTATACTAAAAAGTGGAGGGAGATTTGTTTAAACAAGTATTTCTAAAAGAAATATGTACATAGT
 641 TCTGGAAATTATTTGTGGTAAGGAAATATTCTTTACTCCAGTTGCATTTCTCAGACAATAAAGTGGTGCATCCATGCTAC
 721 CTCCTACTTTGTCAACAAAGATGCTATTTACCCTTTACATTTTTGTATCATAATAGATTTTAAAAATCTAATGTTCTTTA
 801 TTGCAAGACATTCTTTTGTTAACAGGTTTGTTTCTTTTTAATGTTTTACCTAAAATTTGACATGCTTACAGGACAGGTTT
 881 GCCTCTTACTTTATTTAACATTGTAGAAATGTAATTAATAAACAATGCTCACTACACAGTTTAGAATAGACGTTCTCATT
 961 TATATTATCTTCCAAATTTGATCAGTTAGCAAAACTTAATACACCAATTAAAATATTTCTACATATGAGAATGTTTACAA
1041 TTTAAATTTTAGAACTTGTTTTGGATGTGATTATATGTACGAAAATCGTGTAACACTATGCTCATGCTAAGAACCGACAT
1121 AACAGAATTACTGAAATAAATGTGCTGTGAGGAATGGAAAATATGGTGCAGGTGTCTTGGTCATGATAAATTGTGATTCT
1201 TTTTAAAAATTTTTTCCAAAAACAATTAGGTATTTTAATCTGAAATCAGATTCCTTTACAAACAACAAGTTTTTGTATGC
1281 AAGCACCATTTTATTTCATGTAGTATGGCTAATACTATAGTTGAACCAAGGATATGCATTGATTCTTTGCTTCGTATGTA
1361 AATAAAGTTAAAAACAGTTAAAATAAGGAGTATTTTGGTAGAGTATATACATACCTCACTGCCAGTGAAATTGCTTTCCT
1441 ATGGTATATCTCCTTACCAGAAAAATCTCTAAATAAAAAAAGGTTTAAAGAAAATTAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggUCGAUUGU-UAU---GUGACGGa 5'
             ||:  |:| |||   ||||||| 
Target 5' tagAGTATATACATACCTCACTGCCa 3'
1399 - 1424 151.00 -11.70
2
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            :| :|||:|| ||| |||: 
Target 5' tgTAATTAATAA-ACAATGCTc 3'
910 - 930 119.00 -7.70
3
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            |||| | :|||| ||||:: 
Target 5' agCAGCCATTAATAAACTGTTg 3'
262 - 283 116.00 -12.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
31109 592 ClinVar
COSN30136479 9 COSMIC
COSN30539363 10 COSMIC
COSN8638852 12 COSMIC
COSN30187400 18 COSMIC
COSN29793074 22 COSMIC
COSN28189202 52 COSMIC
COSN28871912 53 COSMIC
COSN20047811 54 COSMIC
COSN30458418 67 COSMIC
COSN31573439 76 COSMIC
COSN30102623 98 COSMIC
COSN29876724 153 COSMIC
COSN8146470 329 COSMIC
COSN31573032 360 COSMIC
COSN30543533 441 COSMIC
COSN26492585 459 COSMIC
COSN2837267 496 COSMIC
COSN19383782 524 COSMIC
COSN31520800 607 COSMIC
COSN27904074 733 COSMIC
COSN20090280 821 COSMIC
COSN31595844 1065 COSMIC
COSN31778119 1087 COSMIC
COSN31546122 1226 COSMIC
COSN22801393 1398 COSMIC
COSN31527947 1460 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748711446 5 dbSNP
rs779248405 6 dbSNP
rs201098252 10 dbSNP
rs769065721 12 dbSNP
rs1321659149 21 dbSNP
rs749553890 23 dbSNP
rs1285585806 25 dbSNP
rs1387663369 28 dbSNP
rs780380849 36 dbSNP
rs1366914482 63 dbSNP
rs201325160 63 dbSNP
rs1188713026 68 dbSNP
rs1033236968 69 dbSNP
rs1309357200 71 dbSNP
rs189280996 91 dbSNP
rs1255733601 95 dbSNP
rs776940922 96 dbSNP
rs1022286025 98 dbSNP
rs1202650333 103 dbSNP
rs1293035563 108 dbSNP
rs1320888492 112 dbSNP
rs1023939137 113 dbSNP
rs1011189233 114 dbSNP
rs1219927912 114 dbSNP
rs1246670925 114 dbSNP
rs115980476 116 dbSNP
rs1031208740 117 dbSNP
rs545080909 130 dbSNP
rs1293312871 133 dbSNP
rs1239586142 136 dbSNP
rs1437509814 140 dbSNP
rs1004080114 144 dbSNP
rs1385570283 147 dbSNP
rs1406882173 148 dbSNP
rs768710474 151 dbSNP
rs1162548789 157 dbSNP
rs1349246107 163 dbSNP
rs1383807382 165 dbSNP
rs1333486469 170 dbSNP
rs576373797 180 dbSNP
rs1446253088 185 dbSNP
rs894261970 205 dbSNP
rs531512017 210 dbSNP
rs1450732184 231 dbSNP
rs1408568171 235 dbSNP
rs1177317207 237 dbSNP
rs941205003 238 dbSNP
rs567418152 240 dbSNP
rs187405915 247 dbSNP
rs1456079623 249 dbSNP
rs1177548259 251 dbSNP
rs1243408564 259 dbSNP
rs1454835076 266 dbSNP
rs556425975 269 dbSNP
rs1412935041 272 dbSNP
rs527385595 284 dbSNP
rs181721713 287 dbSNP
rs894169901 293 dbSNP
rs138994338 298 dbSNP
rs545008919 300 dbSNP
rs1337583379 301 dbSNP
rs1342540846 308 dbSNP
rs941316115 310 dbSNP
rs1284045693 316 dbSNP
rs746368524 317 dbSNP
rs1182125932 332 dbSNP
rs1220939439 333 dbSNP
rs145171411 338 dbSNP
rs1256721900 349 dbSNP
rs1459744425 350 dbSNP
rs1315483392 361 dbSNP
rs543083601 366 dbSNP
rs1203798076 376 dbSNP
rs933785932 385 dbSNP
rs910665781 389 dbSNP
rs1207747150 392 dbSNP
rs986150148 392 dbSNP
rs1236737413 402 dbSNP
rs1475623636 406 dbSNP
rs957552810 409 dbSNP
rs1195707222 411 dbSNP
rs922725014 430 dbSNP
rs1249062388 431 dbSNP
rs190122740 439 dbSNP
rs757648838 440 dbSNP
rs574268999 443 dbSNP
rs1177299237 447 dbSNP
rs1404615959 451 dbSNP
rs1307938292 456 dbSNP
rs1413040409 462 dbSNP
rs1333769829 467 dbSNP
rs770417021 476 dbSNP
rs1402276333 482 dbSNP
rs1276802205 486 dbSNP
rs1340499445 501 dbSNP
rs1314197056 502 dbSNP
rs555902992 512 dbSNP
rs879092714 523 dbSNP
rs967688737 524 dbSNP
rs1346665108 527 dbSNP
rs942747478 529 dbSNP
rs185345687 531 dbSNP
rs1488468744 537 dbSNP
rs989477189 545 dbSNP
rs1260900527 553 dbSNP
rs1200218911 554 dbSNP
rs191682078 554 dbSNP
rs879723323 554 dbSNP
rs559988697 558 dbSNP
rs188691139 560 dbSNP
rs971279698 563 dbSNP
rs539446101 568 dbSNP
rs1296776154 569 dbSNP
rs574150348 575 dbSNP
rs780921940 578 dbSNP
rs1326120666 579 dbSNP
rs748699866 579 dbSNP
rs1230473014 582 dbSNP
rs894220651 588 dbSNP
rs183644696 589 dbSNP
rs1242047530 591 dbSNP
rs587776903 592 dbSNP
rs1352732618 596 dbSNP
rs1005139065 599 dbSNP
rs887040378 607 dbSNP
rs1046896829 613 dbSNP
rs1233635793 615 dbSNP
rs1441844354 631 dbSNP
rs1157216552 636 dbSNP
rs1380006861 641 dbSNP
rs929788704 653 dbSNP
rs754567101 656 dbSNP
rs1425688431 660 dbSNP
rs901129474 665 dbSNP
rs933903371 666 dbSNP
rs1188952 676 dbSNP
rs1384538565 679 dbSNP
rs1322384369 692 dbSNP
rs1386206941 697 dbSNP
rs538114181 702 dbSNP
rs1183847765 709 dbSNP
rs944736733 713 dbSNP
rs1436805541 718 dbSNP
rs1377169765 726 dbSNP
rs765870508 735 dbSNP
rs910519591 744 dbSNP
rs942799684 746 dbSNP
rs1375823971 751 dbSNP
rs757845664 759 dbSNP
rs915289321 761 dbSNP
rs543966714 767 dbSNP
rs1209312256 771 dbSNP
rs1258859396 785 dbSNP
rs1459151593 788 dbSNP
rs1480953275 792 dbSNP
rs1176927899 803 dbSNP
rs149184403 808 dbSNP
rs1424742545 809 dbSNP
rs534765347 821 dbSNP
rs924234234 824 dbSNP
rs1457895867 825 dbSNP
rs1169014634 826 dbSNP
rs1315420750 833 dbSNP
rs1466761598 841 dbSNP
rs1328807495 842 dbSNP
rs977596530 849 dbSNP
rs982795300 860 dbSNP
rs970991803 861 dbSNP
rs1238625610 866 dbSNP
rs967930695 869 dbSNP
rs527530428 870 dbSNP
rs765044003 873 dbSNP
rs1024257513 881 dbSNP
rs1243896779 883 dbSNP
rs796662424 889 dbSNP
rs993461332 889 dbSNP
rs148951903 892 dbSNP
rs751888500 900 dbSNP
rs1016606840 903 dbSNP
rs958419151 911 dbSNP
rs1202533268 920 dbSNP
rs565992127 925 dbSNP
rs566568739 930 dbSNP
rs1158347775 936 dbSNP
rs886753971 942 dbSNP
rs1426438283 947 dbSNP
rs1478503706 951 dbSNP
rs1025293665 952 dbSNP
rs1399087218 955 dbSNP
rs1183421052 957 dbSNP
rs1304238223 959 dbSNP
rs1419124072 962 dbSNP
rs551448999 964 dbSNP
rs1005313640 967 dbSNP
rs1267511963 970 dbSNP
rs1220198481 987 dbSNP
rs1342339523 998 dbSNP
rs1490804682 998 dbSNP
rs780406992 999 dbSNP
rs901085119 1002 dbSNP
rs1312863293 1004 dbSNP
rs1235609732 1010 dbSNP
rs76101054 1015 dbSNP
rs1025397679 1016 dbSNP
rs1053846316 1023 dbSNP
rs1344988796 1025 dbSNP
rs1487631286 1030 dbSNP
rs935410770 1034 dbSNP
rs562432922 1051 dbSNP
rs1418090419 1054 dbSNP
rs900972492 1080 dbSNP
rs1040984575 1081 dbSNP
rs1375590919 1085 dbSNP
rs1046386929 1086 dbSNP
rs1007181159 1087 dbSNP
rs1362368155 1088 dbSNP
rs1398011376 1094 dbSNP
rs1407300556 1098 dbSNP
rs1368349349 1101 dbSNP
rs1346693758 1104 dbSNP
rs145370813 1115 dbSNP
rs529569741 1116 dbSNP
rs963487841 1127 dbSNP
rs1288672740 1128 dbSNP
rs909655338 1142 dbSNP
rs1457400908 1144 dbSNP
rs935999464 1152 dbSNP
rs1444210717 1154 dbSNP
rs150006875 1163 dbSNP
rs1488492140 1168 dbSNP
rs1192471768 1172 dbSNP
rs74592874 1188 dbSNP
rs1453486884 1191 dbSNP
rs1025768453 1192 dbSNP
rs750651805 1196 dbSNP
rs1481408770 1208 dbSNP
rs13368 1209 dbSNP
rs573151637 1210 dbSNP
rs1459479518 1227 dbSNP
rs1445095504 1229 dbSNP
rs1018175921 1238 dbSNP
rs1006745055 1240 dbSNP
rs1447719367 1243 dbSNP
rs17131232 1250 dbSNP
rs1053606406 1254 dbSNP
rs775767339 1259 dbSNP
rs993098866 1265 dbSNP
rs1291186638 1266 dbSNP
rs1324098297 1266 dbSNP
rs959179062 1273 dbSNP
rs1263108630 1274 dbSNP
rs1046834955 1277 dbSNP
rs949381854 1286 dbSNP
rs1239644563 1288 dbSNP
rs1437569360 1289 dbSNP
rs1225416033 1294 dbSNP
rs927522500 1314 dbSNP
rs1324949082 1320 dbSNP
rs983828419 1327 dbSNP
rs952339547 1332 dbSNP
rs1025411061 1334 dbSNP
rs1162614955 1337 dbSNP
rs1429192007 1340 dbSNP
rs916844906 1345 dbSNP
rs1328586818 1353 dbSNP
rs772294901 1354 dbSNP
rs1055282606 1356 dbSNP
rs1285218363 1360 dbSNP
rs761953398 1363 dbSNP
rs1435373616 1364 dbSNP
rs1389524339 1367 dbSNP
rs771791888 1379 dbSNP
rs965244224 1380 dbSNP
rs1173693537 1387 dbSNP
rs1470651246 1402 dbSNP
rs1333461924 1405 dbSNP
rs1425205249 1408 dbSNP
rs1259556532 1410 dbSNP
rs1456219719 1415 dbSNP
rs1167283542 1419 dbSNP
rs569612507 1433 dbSNP
rs1180001632 1434 dbSNP
rs1474351414 1434 dbSNP
rs549645395 1436 dbSNP
rs1417102277 1439 dbSNP
rs1006714709 1440 dbSNP
rs889738092 1443 dbSNP
rs1172953582 1445 dbSNP
rs1409547768 1446 dbSNP
rs867536929 1450 dbSNP
rs575116495 1456 dbSNP
rs1053611046 1475 dbSNP
rs1000180439 1481 dbSNP
rs1193626689 1482 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84146.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cggucgAU-UGU-UAU---GUGACGGa 5'
                || |:| |||   ||||||| 
Target 5' ------UAUAUACAUACCUCACUGCCa 3'
1 - 21
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000370440.1 | 3UTR | UAUAUACAUACCUCACUGCCAGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19783 ER- ER- breast cancer -0.314 2.4e-3 -0.358 6.0e-4 79 Click to see details
GSE19536 Breast cancer -0.263 4.1e-3 -0.308 9.1e-4 100 Click to see details
GSE26953 Aortic valvular endothelial cells 0.447 1.4e-2 0.383 3.2e-2 24 Click to see details
GSE28544 Breast cancer -0.447 1.4e-2 -0.292 8.3e-2 24 Click to see details
GSE19350 CNS germ cell tumors -0.599 2.0e-2 -0.196 2.7e-1 12 Click to see details
GSE27834 Pluripotent stem cells -0.51 2.2e-2 0.141 3.0e-1 16 Click to see details
GSE17306 Multiple myeloma 0.277 2.7e-2 0.330 1.0e-2 49 Click to see details
GSE42095 Differentiated embryonic stem cells -0.34 5.6e-2 -0.543 3.7e-3 23 Click to see details
GSE14794 Lymphoblastoid cells 0.133 1.1e-1 0.071 2.5e-1 90 Click to see details
GSE19783 ER+ ER+ breast cancer -0.235 1.6e-1 -0.277 1.2e-1 20 Click to see details
GSE28260 Renal cortex and medulla 0.275 1.8e-1 0.335 1.3e-1 13 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.326 2.2e-1 -0.429 1.4e-1 8 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.078 3.6e-1 -0.015 4.7e-1 25 Click to see details
GSE21849 B cell lymphoma 0.06 3.8e-1 0.020 4.6e-1 29 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.061 4.0e-1 -0.498 1.3e-2 20 Click to see details
GSE38226 Liver fibrosis 0.059 4.0e-1 0.157 2.5e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.023 4.6e-1 -0.034 4.4e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.009 4.8e-1 -0.010 4.8e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.004 4.9e-1 -0.017 4.5e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.994 0.03 0.500 0.33 3 Click to see details
BRCA 0.41 0.3 0.800 0.1 4 Click to see details
LUSC -0.275 0.36 0.200 0.4 4 Click to see details
UCEC 0.138 0.37 0.143 0.37 8 Click to see details
UCEC 0.138 0.37 0.143 0.37 8 Click to see details
UCEC 0.138 0.37 0.143 0.37 8 Click to see details
UCEC 0.138 0.37 0.143 0.37 8 Click to see details
UCEC 0.138 0.37 0.143 0.37 8 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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