pre-miRNA Information | |
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pre-miRNA | hsa-mir-4666a |
Genomic Coordinates | chr1: 228462074 - 228462152 |
Description | Homo sapiens miR-4666a stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-4666a-5p | |||||||||||||||||||||||||||
Sequence | 10| AUACAUGUCAGAUUGUAUGCC |30 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZNF451 | ||||||||||||||||||||
Synonyms | COASTER, dJ417I1.1 | ||||||||||||||||||||
Description | zinc finger protein 451 | ||||||||||||||||||||
Transcript | NM_001031623 | ||||||||||||||||||||
Other Transcripts | NM_015555 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZNF451 | |||||||||||||||||||||
3'UTR of ZNF451 (miRNA target sites are highlighted) |
>ZNF451|NM_001031623|3'UTR 1 TTAAAGATATTACCACACAACATCAAGTGGCCTTGAAGAGACTGAGATAACGAATTCTTGAGTTTGTTTTCTAAAGGAGA 81 CCAGAAATCCACTATTACAAATGTATTTGAAAACATGTTTTTGCTTTCATATGTTCAAAATCTGATCTTTGTTTTGTATT 161 TTTGTGCTAATGTGCAAACATGTACAGAAGAAATAGAATACATGTTCATGCAAATATAAATTATGTATTCTAATATAGGT 241 GTAACAGTTTCCCAGTTAACTTTGAATTTATATATTTAGATTTAAAGGATTAAAAAAAAGGAAAGCTCTTGACAGTTGTT 321 TCCCAAATAGCATTAGTTCTTTAATTTTATTTGTACTGTACAAATGATGCTAGTTTATTTTTTTAGCAGTGAAAATGAAT 401 ATAAAAAAGGTGACATAGGTCAAGTTTTCCATAAATTCTACTTCTCATGTGGCACTATTATATAATACCTTTGAGATCTT 481 TGTTTATGTTTATTAGAAGAGGGTAATGGAAACTGATCATGGAAACATTTAAAATTTTATCAGCAATGTTCTTTGTGGGT 561 GCCATGCATATGTAAATTATTGCTTTAATTAGAGCAGCACATTGCTAAAATAAAAAATACACCTTAATTTTTAAGAAATA 641 ATTTAAATGAAACAATTTCCATTCCTTTTACCTGCTTAGACTTTTATGTGACTTGTATGGTCTCCTGGTTAAAGGGAATG 721 GTGTCAGAATATTTGCATAAAATTATTTTTCATAACAGTCCTTTTTTATATATTGGTGTAAACATAATATTCTTCAAGAA 801 ATAATGTTGAAAGCCTACTCAGGAATAATCTTCCTTAACTCTTTAAATTTTTATTTCATGTGAAGTGTTTTCAGTTTAGT 881 TATTCACTGAATTGTCAGTTTCCTTCATTTGGTATTACATATTTAATTCTTAAATATTGAGGCCCCATTGTGAGTAATAA 961 AAAATACGACATAAGTAGAAGACTAAGAAGGGCTTGTCATATTATCTTTGTGTATATGCTTCATGTTATTTAACCAGAAA 1041 TGTCTTATCTCTAAAAATTTTTAGTAGTAATTATTTACCAAACTTAAAAACATTTCTATAAATATAAAGCTTTTCTTTAT 1121 ATTTAAGACAAAATATAAAGGCTAGAATTTGGTTCCTTCTCTGTAACACTAAATATTTTAGTGTGAAATTGAATTTTTTT 1201 ATTACTATAGTCTTTTCAATCTATAATTTGTGTTTTTAATTTCTTGATATGTCACTTCTGTTCCTCCCTGCTTGCATTTT 1281 TTAAAAACTAGACATTGTGGCTTGAGAATTTATCAATCATCTTTCCGAAATGACCACATTGTGCTTTTAGTTTGTATGTT 1361 TAAGTGGTCAAGCAAGGCTCTAGGAGGTAGTCACTGAGCTGGACCTTAAACACATCTGCAGGAGCTCACAAAATGGGAGC 1441 AAAAGAGGCATTCCAGAAAGAAGAGTAGTTAAGCAGATGTGGGGGCAGGGCAAGAGGAGACAGCACCTTGTTGCCAGAGA 1521 TTCTACACAAAGGTGTGATGGACACTGATGCTCTATTAAGAAGCTTTTGTGGTGTGTGTGGTAGAGAATAATTAAGGCTT 1601 CTGATAAGACAGGAAAGGGATATTTCATCATGACTGTTAAGAAAAGGTAACTGGGTTGTTTAATGTTTTAATTGATAATT 1681 GTCACTGATCGTATTTCTACTTGTTAAATAATTAAAAATCATCTTAAAATTCATACTTTGACTTTAATTTAGACACAAGG 1761 AGATGTAATCGCTGTGTAACATCAGAGAAAGCTATATGGATTATCGTCAGAAGTAAATGTTTCTAACATTG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 26036.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000370708.4 | 3UTR | UAACAGCAUGUAAAUGUUC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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83 hsa-miR-4666a-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT057266 | FAM35A | family with sequence similarity 35 member A | 2 | 2 | ||||||||
MIRT059969 | PATL1 | PAT1 homolog 1, processing body mRNA decay factor | 2 | 6 | ||||||||
MIRT079031 | TNRC6C | trinucleotide repeat containing 6C | 2 | 2 | ||||||||
MIRT079631 | DNAJB4 | DnaJ heat shock protein family (Hsp40) member B4 | 2 | 2 | ||||||||
MIRT086974 | LANCL1 | LanC like 1 | 2 | 2 | ||||||||
MIRT091804 | GOLGA4 | golgin A4 | 2 | 2 | ||||||||
MIRT229501 | EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 2 | 4 | ||||||||
MIRT255972 | WDR17 | WD repeat domain 17 | 2 | 2 | ||||||||
MIRT262975 | ADO | 2-aminoethanethiol dioxygenase | 2 | 2 | ||||||||
MIRT264774 | PAFAH1B2 | platelet activating factor acetylhydrolase 1b catalytic subunit 2 | 2 | 2 | ||||||||
MIRT334169 | CCND1 | cyclin D1 | 2 | 6 | ||||||||
MIRT345868 | SRSF2 | serine and arginine rich splicing factor 2 | 2 | 2 | ||||||||
MIRT452477 | DDX4 | DEAD-box helicase 4 | 2 | 2 | ||||||||
MIRT455764 | TSPAN6 | tetraspanin 6 | 2 | 4 | ||||||||
MIRT461627 | DCAF15 | DDB1 and CUL4 associated factor 15 | 2 | 4 | ||||||||
MIRT465169 | TRPV2 | transient receptor potential cation channel subfamily V member 2 | 2 | 4 | ||||||||
MIRT468950 | RPS14 | ribosomal protein S14 | 2 | 6 | ||||||||
MIRT483236 | C2orf72 | chromosome 2 open reading frame 72 | 2 | 8 | ||||||||
MIRT498544 | TMEM30B | transmembrane protein 30B | 2 | 2 | ||||||||
MIRT500633 | TXNIP | thioredoxin interacting protein | 2 | 4 | ||||||||
MIRT504113 | GPR158 | G protein-coupled receptor 158 | 2 | 2 | ||||||||
MIRT504428 | ZNF85 | zinc finger protein 85 | 2 | 6 | ||||||||
MIRT505036 | ZNF451 | zinc finger protein 451 | 2 | 2 | ||||||||
MIRT506526 | MRPL17 | mitochondrial ribosomal protein L17 | 2 | 6 | ||||||||
MIRT508773 | GSG1 | germ cell associated 1 | 2 | 2 | ||||||||
MIRT517297 | ELF4 | E74 like ETS transcription factor 4 | 2 | 6 | ||||||||
MIRT519353 | OBFC1 | STN1, CST complex subunit | 2 | 4 | ||||||||
MIRT523891 | ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | 2 | 6 | ||||||||
MIRT527509 | ZNF134 | zinc finger protein 134 | 2 | 2 | ||||||||
MIRT531218 | IFNGR2 | interferon gamma receptor 2 | 2 | 2 | ||||||||
MIRT535957 | MOGAT1 | monoacylglycerol O-acyltransferase 1 | 2 | 2 | ||||||||
MIRT537229 | GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | 2 | 4 | ||||||||
MIRT537337 | FKBP5 | FK506 binding protein 5 | 2 | 2 | ||||||||
MIRT539125 | ARHGEF17 | Rho guanine nucleotide exchange factor 17 | 2 | 2 | ||||||||
MIRT539910 | ISPD | isoprenoid synthase domain containing | 2 | 2 | ||||||||
MIRT541527 | MGAT4C | MGAT4 family member C | 2 | 2 | ||||||||
MIRT546119 | USP25 | ubiquitin specific peptidase 25 | 2 | 2 | ||||||||
MIRT548846 | CERCAM | cerebral endothelial cell adhesion molecule | 2 | 2 | ||||||||
MIRT549892 | LINC00955 | long intergenic non-protein coding RNA 955 | 2 | 2 | ||||||||
MIRT549898 | ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide | 2 | 2 | ||||||||
MIRT550763 | ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | 2 | 4 | ||||||||
MIRT553200 | UBE2A | ubiquitin conjugating enzyme E2 A | 2 | 2 | ||||||||
MIRT553970 | SRSF10 | serine and arginine rich splicing factor 10 | 2 | 2 | ||||||||
MIRT554092 | SMU1 | DNA replication regulator and spliceosomal factor | 2 | 2 | ||||||||
MIRT555208 | PROX1 | prospero homeobox 1 | 2 | 4 | ||||||||
MIRT555834 | PAX5 | paired box 5 | 2 | 4 | ||||||||
MIRT556865 | JAZF1 | JAZF zinc finger 1 | 2 | 2 | ||||||||
MIRT558594 | CREBL2 | cAMP responsive element binding protein like 2 | 2 | 2 | ||||||||
MIRT559690 | AGO2 | argonaute 2, RISC catalytic component | 2 | 4 | ||||||||
MIRT563312 | ORC4 | origin recognition complex subunit 4 | 2 | 2 | ||||||||
MIRT563585 | FAM229B | family with sequence similarity 229 member B | 2 | 2 | ||||||||
MIRT563853 | ALYREF | Aly/REF export factor | 2 | 4 | ||||||||
MIRT565146 | TUBB2A | tubulin beta 2A class IIa | 2 | 2 | ||||||||
MIRT565769 | SEPHS1 | selenophosphate synthetase 1 | 2 | 2 | ||||||||
MIRT568317 | BACH1 | BTB domain and CNC homolog 1 | 2 | 2 | ||||||||
MIRT575387 | Unc5b | unc-5 netrin receptor B | 2 | 4 | ||||||||
MIRT607728 | BDH1 | 3-hydroxybutyrate dehydrogenase 1 | 2 | 8 | ||||||||
MIRT612691 | PLXNA4 | plexin A4 | 2 | 4 | ||||||||
MIRT615916 | GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | 2 | 2 | ||||||||
MIRT629792 | P2RY1 | purinergic receptor P2Y1 | 2 | 2 | ||||||||
MIRT632119 | FKBP9 | FK506 binding protein 9 | 2 | 2 | ||||||||
MIRT645554 | ZDHHC15 | zinc finger DHHC-type containing 15 | 2 | 4 | ||||||||
MIRT651479 | WWC3 | WWC family member 3 | 2 | 2 | ||||||||
MIRT654138 | RPH3A | rabphilin 3A | 2 | 6 | ||||||||
MIRT655191 | PHAX | phosphorylated adaptor for RNA export | 2 | 2 | ||||||||
MIRT665543 | UNC5B | unc-5 netrin receptor B | 2 | 5 | ||||||||
MIRT668057 | GRIK3 | glutamate ionotropic receptor kainate type subunit 3 | 2 | 2 | ||||||||
MIRT678978 | CERS4 | ceramide synthase 4 | 2 | 4 | ||||||||
MIRT679124 | RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 2 | 2 | ||||||||
MIRT686776 | AZF1 | azoospermia factor 1 | 2 | 2 | ||||||||
MIRT687144 | PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 2 | 2 | ||||||||
MIRT691453 | C21orf58 | chromosome 21 open reading frame 58 | 2 | 2 | ||||||||
MIRT691469 | FAM98B | family with sequence similarity 98 member B | 2 | 2 | ||||||||
MIRT697031 | UHRF1BP1 | UHRF1 binding protein 1 | 2 | 2 | ||||||||
MIRT698401 | TM9SF3 | transmembrane 9 superfamily member 3 | 2 | 2 | ||||||||
MIRT702056 | RNMT | RNA guanine-7 methyltransferase | 2 | 2 | ||||||||
MIRT705903 | ADAM9 | ADAM metallopeptidase domain 9 | 2 | 2 | ||||||||
MIRT707491 | MMADHC | methylmalonic aciduria and homocystinuria, cblD type | 2 | 2 | ||||||||
MIRT708080 | KLHL23 | kelch like family member 23 | 2 | 2 | ||||||||
MIRT709738 | TRIM27 | tripartite motif containing 27 | 2 | 2 | ||||||||
MIRT710056 | RWDD2A | RWD domain containing 2A | 2 | 2 | ||||||||
MIRT710226 | KCNK1 | potassium two pore domain channel subfamily K member 1 | 2 | 2 | ||||||||
MIRT712043 | STYK1 | serine/threonine/tyrosine kinase 1 | 2 | 2 |