pre-miRNA Information | |
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pre-miRNA | hsa-mir-4436b-1 |
Genomic Coordinates | chr2: 110086433 - 110086523 |
Description | Homo sapiens miR-4436b-1 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
pre-miRNA | hsa-mir-4436b-2 |
Genomic Coordinates | chr2: 110284853 - 110284943 |
Description | Homo sapiens miR-4436b-2 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||
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Mature miRNA | hsa-miR-4436b-3p | ||||||
Sequence | 60| CAGGGCAGGAAGAAGUGGACAA |81 | ||||||
Evidence | Experimental | ||||||
Experiments | Illumina | ||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SMUG1 | ||||||||||||||||||||
Synonyms | FDG, HMUDG, UNG3 | ||||||||||||||||||||
Description | single-strand-selective monofunctional uracil-DNA glycosylase 1 | ||||||||||||||||||||
Transcript | NM_014311 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SMUG1 | |||||||||||||||||||||
3'UTR of SMUG1 (miRNA target sites are highlighted) |
>SMUG1|NM_014311|3'UTR 1 GTGCCCTTGGGGCCTTGCATGGGACACATTCAAGACCTCGAAGTCATTCTTGGCCAAGCAGATGACAACACATCTCCTGG 81 ACTGGAGCAAAAGGTCCTTCTGTGCACCCTGGTCGCTGGGAAACGTATTCTTTGATCTGTTGAACTGTCTTCCAACCTGC 161 CATGGCAGTTTTGACACTACTCCTGTTTGCCCTCCTGATTCCTGCTTTCTTTACCTTTTAACATTGCCCCTTTCAGGGGA 241 CCCCACTTTGTAGGGAATCTGCAGAAGGTGTGCTTTTGCACTTGCAGACTGCTCTACCTCAGTGTTTCCTTGGGAGACTT 321 TATTCAGCTGAGAGTGCCCTAGACAGTAACTTCTAAGGTCACGTTTACTATTTCAGAGGAAATATCTTGCCAGGATACCT 401 ACCCATCCTTATAGAACAGTTACCTTTAGCTGACCCCTTTCCTCACAGGGACCAAGACAAAGCATGGGACATGAAATTAA 481 GAGTGAACTTCTTATGGGAGGCTGCAGCTGGATCAGAGGAAAAATCCAGTGTGACAGAGTGCAAGTCAGAAGACCTGGCT 561 TTTCATCCCAGCTTTGAAACTTGGAACTTTTTGATTGACAAATTAATAAACCTCTCTATGCCTCAGGCTCCTCATCTGTA 641 AAACAGGGATGCCTACCTTATGGGGTTGGTGTGAGGATTAACTGAGATCACACTTGAAAGTGCCTTGCATGGGCTTGGCA 721 TGTGGGTGCTCATTACATAGTCTTCTTGTTTTCTTGCCTCTGGGTTGAGGATTCACAGCACTGCACTACAAGGGTAGCCC 801 CTCTCCATTCTGGATACCTTGCTAGGAGAGAGTCTGGGCTTCCACCTGCGGCCAGGGTGAAGGGAAAATTCTTGCCATGT 881 CAGAGATGGATCAATGACTATGAAAAAACTAGCCTGTGATTTTTTTTCACTCTAAGCATTAAGAGCTCCTAAAGCCTTTT 961 GTCTTGTTACTTTTTTCCCCCTCTTGCATGCTAGAGGTGGAAGGTAGTCATTTAGATTTCCCCCCTCTTCCCTCTTCATT 1041 GTTGGCCAGGGGTTCTCTTGGGCAGCTGGGGGAAGGATGTAGTAGATCTCTCTTTTTTTTTTTTTTTTGAGATGGAGTCT 1121 CATGCTGTTGCCCAGGCTGGAGTGCAGTGGCATGGTCTCAGTTCACTGCAACATCTGCTTTCCCGGTTCAAGTGATTCTC 1201 CTGCCTCAGCCTCCTGTATAGCTGGAATTACAGGCATGTGCCACCACGCCTGGCTAATTTTTGTATTTTTATTAAAGACA 1281 GTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACTTCAAGTAATCCACCTGTCTTGGCCTCCCAAAGTGCTGC 1361 TGCCTGGCTGGATGTAGCAGATCTCCAATTGCCTTACCAAACCTGCAGGGTCTCTGTTAAGTGTCTGTTAGGGGTCTTAT 1441 ATGATACTCTGGACACCGTGAGAAACAGGTGATGGGGCAGATGGGAACCTGGTATCCAACTCATTTTTTATGTCTGCTGA 1521 ATGGTTGACTGGGTGCCCCTTTGGTAAGGGCTGGGAAAGTGAACCAAGTTGGGAGCAGAGCAGGTCTTGAGACCACCTTA 1601 ATGAGGAACACATGGTCTACTTCCTATCTCCTGGGACACAGGTCATTTCCAGCTTCCAGAATTAGTAAGATTTTTCATAT 1681 AAATCCTCCCCTACTTCATTGTATAATAAAGAATTTGGCCTTTGTCTTCAGTTCCTGAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 23583.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000505128.1 | 3UTR | ACUUUAUUCAGCUGAGAGUGCCCUAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT066957 | ATXN7L3B | ataxin 7 like 3B | ![]() |
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2 | 8 | ||||||
MIRT119284 | NABP1 | nucleic acid binding protein 1 | ![]() |
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2 | 6 | ||||||
MIRT128915 | KMT2A | lysine methyltransferase 2A | ![]() |
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2 | 2 | ||||||
MIRT150116 | MIDN | midnolin | ![]() |
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2 | 2 | ||||||
MIRT173040 | YTHDF3 | YTH N6-methyladenosine RNA binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT253117 | BCL2L12 | BCL2 like 12 | ![]() |
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2 | 2 | ||||||
MIRT256997 | RGMB | repulsive guidance molecule family member b | ![]() |
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2 | 2 | ||||||
MIRT259746 | SNX12 | sorting nexin 12 | ![]() |
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2 | 2 | ||||||
MIRT267278 | TMEM109 | transmembrane protein 109 | ![]() |
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2 | 2 | ||||||
MIRT441934 | C1orf109 | chromosome 1 open reading frame 109 | ![]() |
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2 | 2 | ||||||
MIRT443625 | CPSF2 | cleavage and polyadenylation specific factor 2 | ![]() |
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2 | 2 | ||||||
MIRT445757 | AGO1 | argonaute 1, RISC catalytic component | ![]() |
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2 | 2 | ||||||
MIRT447835 | CTIF | cap binding complex dependent translation initiation factor | ![]() |
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2 | 2 | ||||||
MIRT451230 | ZNF444 | zinc finger protein 444 | ![]() |
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2 | 2 | ||||||
MIRT451966 | TMPRSS5 | transmembrane protease, serine 5 | ![]() |
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2 | 2 | ||||||
MIRT453127 | HOXC4 | homeobox C4 | ![]() |
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2 | 2 | ||||||
MIRT454604 | RPL13A | ribosomal protein L13a | ![]() |
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2 | 2 | ||||||
MIRT455176 | SUV39H1 | suppressor of variegation 3-9 homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT455547 | GJB1 | gap junction protein beta 1 | ![]() |
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2 | 2 | ||||||
MIRT458197 | ATP6V0A2 | ATPase H+ transporting V0 subunit a2 | ![]() |
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2 | 2 | ||||||
MIRT458356 | NOC2L | NOC2 like nucleolar associated transcriptional repressor | ![]() |
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2 | 2 | ||||||
MIRT458923 | DNM2 | dynamin 2 | ![]() |
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2 | 2 | ||||||
MIRT461013 | SYT7 | synaptotagmin 7 | ![]() |
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2 | 2 | ||||||
MIRT461643 | ZSWIM4 | zinc finger SWIM-type containing 4 | ![]() |
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2 | 2 | ||||||
MIRT461997 | PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | ![]() |
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2 | 2 | ||||||
MIRT462367 | BCL7B | BCL tumor suppressor 7B | ![]() |
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2 | 2 | ||||||
MIRT464915 | TXNIP | thioredoxin interacting protein | ![]() |
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2 | 2 | ||||||
MIRT466311 | TIMM22 | translocase of inner mitochondrial membrane 22 | ![]() |
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2 | 2 | ||||||
MIRT466591 | TBC1D2B | TBC1 domain family member 2B | ![]() |
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2 | 2 | ||||||
MIRT467045 | SRSF1 | serine and arginine rich splicing factor 1 | ![]() |
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2 | 2 | ||||||
MIRT468750 | SDC2 | syndecan 2 | ![]() |
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2 | 2 | ||||||
MIRT468943 | RPS24 | ribosomal protein S24 | ![]() |
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2 | 2 | ||||||
MIRT469474 | REEP5 | receptor accessory protein 5 | ![]() |
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2 | 2 | ||||||
MIRT469913 | PTRF | caveolae associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT473325 | MEX3A | mex-3 RNA binding family member A | ![]() |
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2 | 2 | ||||||
MIRT473643 | MARK2 | microtubule affinity regulating kinase 2 | ![]() |
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2 | 2 | ||||||
MIRT474064 | LMNB2 | lamin B2 | ![]() |
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2 | 2 | ||||||
MIRT474357 | KMT2D | lysine methyltransferase 2D | ![]() |
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2 | 2 | ||||||
MIRT475394 | ICMT | isoprenylcysteine carboxyl methyltransferase | ![]() |
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2 | 4 | ||||||
MIRT476335 | GLTSCR1L | BRD4 interacting chromatin remodeling complex associated protein like | ![]() |
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2 | 2 | ||||||
MIRT478651 | CTDNEP1 | CTD nuclear envelope phosphatase 1 | ![]() |
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2 | 2 | ||||||
MIRT479585 | CDC42SE1 | CDC42 small effector 1 | ![]() |
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2 | 2 | ||||||
MIRT479943 | CBX5 | chromobox 5 | ![]() |
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2 | 2 | ||||||
MIRT482001 | AMOTL2 | angiomotin like 2 | ![]() |
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2 | 2 | ||||||
MIRT482043 | AMER1 | APC membrane recruitment protein 1 | ![]() |
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2 | 2 | ||||||
MIRT483070 | EXT2 | exostosin glycosyltransferase 2 | ![]() |
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2 | 6 | ||||||
MIRT484323 | KCNH1 | potassium voltage-gated channel subfamily H member 1 | ![]() |
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2 | 4 | ||||||
MIRT487528 | GXYLT2 | glucoside xylosyltransferase 2 | ![]() |
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2 | 2 | ||||||
MIRT489636 | ALS2CL | ALS2 C-terminal like | ![]() |
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2 | 2 | ||||||
MIRT490693 | SSTR1 | somatostatin receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT490871 | UPK2 | uroplakin 2 | ![]() |
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2 | 2 | ||||||
MIRT492582 | PPM1L | protein phosphatase, Mg2+/Mn2+ dependent 1L | ![]() |
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2 | 2 | ||||||
MIRT492945 | NEUROD2 | neuronal differentiation 2 | ![]() |
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2 | 2 | ||||||
MIRT498675 | SOD2 | superoxide dismutase 2 | ![]() |
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2 | 4 | ||||||
MIRT499349 | RAB25 | RAB25, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT502338 | GIGYF1 | GRB10 interacting GYF protein 1 | ![]() |
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2 | 4 | ||||||
MIRT502976 | CCNL1 | cyclin L1 | ![]() |
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2 | 8 | ||||||
MIRT503706 | NUP62 | nucleoporin 62 | ![]() |
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2 | 2 | ||||||
MIRT505567 | SMUG1 | single-strand-selective monofunctional uracil-DNA glycosylase 1 | ![]() |
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2 | 2 | ||||||
MIRT507808 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
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2 | 2 | ||||||
MIRT513242 | FBXO41 | F-box protein 41 | ![]() |
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2 | 6 | ||||||
MIRT513586 | EVX1 | even-skipped homeobox 1 | ![]() |
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2 | 2 | ||||||
MIRT525036 | FRK | fyn related Src family tyrosine kinase | ![]() |
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2 | 2 | ||||||
MIRT531035 | TDGF1P3 | teratocarcinoma-derived growth factor 1 pseudogene 3 | ![]() |
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2 | 2 | ||||||
MIRT531939 | RBMS2 | RNA binding motif single stranded interacting protein 2 | ![]() |
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2 | 2 | ||||||
MIRT534912 | PUM2 | pumilio RNA binding family member 2 | ![]() |
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2 | 2 | ||||||
MIRT535717 | N4BP1 | NEDD4 binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT540498 | ZMAT4 | zinc finger matrin-type 4 | ![]() |
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2 | 4 | ||||||
MIRT541465 | AURKA | aurora kinase A | ![]() |
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2 | 2 | ||||||
MIRT554328 | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1 | ![]() |
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2 | 2 | ||||||
MIRT561572 | SLC6A9 | solute carrier family 6 member 9 | ![]() |
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2 | 2 | ||||||
MIRT564715 | ZNF322P1 | zinc finger protein 322 pseudogene 1 | ![]() |
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2 | 2 | ||||||
MIRT576176 | Hmox1 | heme oxygenase 1 | ![]() |
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2 | 2 | ||||||
MIRT629712 | XKR4 | XK related 4 | ![]() |
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2 | 2 | ||||||
MIRT636182 | THBD | thrombomodulin | ![]() |
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2 | 2 | ||||||
MIRT646315 | MPHOSPH8 | M-phase phosphoprotein 8 | ![]() |
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2 | 2 | ||||||
MIRT649174 | IQSEC1 | IQ motif and Sec7 domain 1 | ![]() |
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2 | 2 | ||||||
MIRT666945 | PMEPA1 | prostate transmembrane protein, androgen induced 1 | ![]() |
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2 | 2 | ||||||
MIRT684057 | FOLR1 | folate receptor 1 | ![]() |
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2 | 2 | ||||||
MIRT687585 | MAU2 | MAU2 sister chromatid cohesion factor | ![]() |
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2 | 2 | ||||||
MIRT689953 | ZNF185 | zinc finger protein 185 with LIM domain | ![]() |
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2 | 2 | ||||||
MIRT704071 | SRCAP | Snf2 related CREBBP activator protein | ![]() |
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2 | 2 | ||||||
MIRT704327 | DCUN1D5 | defective in cullin neddylation 1 domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT705406 | ATP1B3 | ATPase Na+/K+ transporting subunit beta 3 | ![]() |
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2 | 2 | ||||||
MIRT710488 | CDH5 | cadherin 5 | ![]() |
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2 | 2 | ||||||
MIRT718241 | LCE1A | late cornified envelope 1A | ![]() |
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2 | 2 | ||||||
MIRT723182 | CDCA4 | cell division cycle associated 4 | ![]() |
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2 | 2 |