miRTarBase - #MIRT505570


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pre-miRNA Information
pre-miRNA hsa-mir-3189   
Genomic Coordinates chr19: 18386562 - 18386634
Description Homo sapiens miR-3189 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3189-5p
Sequence 9| UGCCCCAUCUGUGCCCUGGGUAGGA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN20065929 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1365326674 4 dbSNP
rs756589279 6 dbSNP
rs780163227 8 dbSNP
rs1283349251 14 dbSNP
rs749362675 15 dbSNP
rs1404459497 24 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMC1A   
Synonyms CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Description structural maintenance of chromosomes 1A
Transcript NM_006306   
Expression
Putative miRNA Targets on SMC1A
3'UTR of SMC1A
(miRNA target sites are highlighted)		 
>SMC1A|NM_006306|3'UTR
   1 CAGTATTTTTGCCCTCCCGCCCTGTCTGGATCCCTAAGCTGTCCCTCTCCCAATCTCTGGATATTTGACTCCCAACCTTC
  81 CCCCTACCTCCTGGCCCTTTTTGGTGTAGTCATGGGATTTAGGCACTGCTAATCAAGCATGAAGAGGAACAGAGGTGATG
 161 TTAGGTCTGGAGCAAAAATTCCTGAACGACAGGGAGTATTCTGGCCTCTGAAAGGAGGTGCTGAGCTGAACAGGGCCATC
 241 TGTTCATCACACACACCCCCTTCCTCCCCCTCATCACCCATAATCGTGGGCCCCTTGGGCCTCTTGCCCACTGTGTGTGT
 321 GGGTATGTATGTGTGTATGTATGTATCCGCATGTGTGCATGTGAGTATGTTTGCAAAATAATAAAGGATATTGGAGACCT
 401 GTTTTAGAAGGAGCCTAGGCTGAATTTGATTCCAAGAGAGCTTAGGATGACAGCACCCCTGAGCTGGGCAAAGGTACTCA
 481 GGACCTCATAGGAGTCTTAGGCAGTTACCTGAAACTGCCTTCATTCACTCATTTGTGTATTCATTCATTTATGTATTCAT
 561 CAGACACATACCGAACACCCTCTATTTGTCAGGCTCTGTGCTTGGAATACAGAGTTGAATCAGACATGATCTCTACCCTC
 641 CTAGTAAGGAGATACAGTGGGTTCATGAATGACTATAGTTAGCTGAATGTCATATGTACTTTGAATTTGAGAAGTGGGTG
 721 ATCCCCTCTAGGCTTCCTGGAGGTCACATTTAAGCTAGACCTTGACAAATTGGTAGGATTTGGTCAGGCACTAGGAGTGG
 801 AGCATGAGCTCTGGGGACAGACAGTTATGGGTTCTGGTCCCACTTTTTATCACTTACTAGTTGTTTGACCTTGGGCAAGT
 881 CATTTGACCTTCTGTGCCTCAGTTTCCTCATCTGTAAAATGGGGCTAACAATATTACCTACCTCATAGGATTTAATGATG
 961 TCAAGCTCCTCACTGGAGGCCTTATCCCTTCGTGGAGCCCACTAGGTGCCGACCCCTCAGAATATAACCCTCATGCCTGG
1041 ACCCCTGAGAGCTTCTGATCCCAGCTATTAGGGACAGAAGAAGCCTCCAAATCTGGAAGGTGCTGAATGCCCTGCTGACT
1121 GGGAAAGTTTCAGGGCACTGATGGGGTCTACCTGGTAAGCGGAGGGCCTGAGGAAACCTGTAGCTTCAATCATGTCTGGT
1201 AACCGGGTGCCTGAGCCCCAATCTGGGTTGTGAGGAAATAGGGGAGAGGTATCCTGGGCCACATCCCAGCCTAACACCTG
1281 TGAGGTTCATTTTAGGAACTAACCTCATTAGCTATAAGGATCATGCAGAGGCAGCAAAGCCGGGTGCGATGAGCTCAGCC
1361 TTTACTCATTCACATACACCATCACACTTTAATTCCAATCTGTATATTGCTTTTTAAAAGTTAAGTCCATTCTAATTACC
1441 CAAATATGCATGAATTCATTCTCCTTTTGAGAAGTTAGATTGTTAAAGATAGTCTCATTCAGCTACCAACCACTCCTTGA
1521 TCCTTCCCTTCTTAGTGGCTGTTGTTTGTTGTACTTCCGTTTAGACTTTGTTTTAATGCTTGTACGTACATATGTGAACT
1601 CATTGGAAATATTGTGTGTTTAATGCAAATGATATATTGAATTGTTTAGCAATTTGTTTTCTTTGCTTAACGATGTTTTT
1681 GAGATCTGTGCATGTTACTTAATGTAGCTCAATCCATCTTCTGTAATTGCTGTATAGATTGTCATCATATGATTACCACA
1761 TTTTACTTACGCATTTCTTTTGTGATGGACATTAAGACTGTTTTTAGGTTTTGCTATTACAAAATACTACACAGGAGCAT
1841 CACTATGCCTGTGTGAAAGTATATGTATGAAAGTTTACCTAGGGTTGATTCCTAGAAGTGGAATTGCAAAGTCATAGGAT
1921 ATTTATATATTGGTTTTTAATAATACTTCCAAATTGCCCTCCTGTACTATTTACTCAGTATTTTTCTTGAGGTTGATCTG
2001 AGGTCTAACATTGTTATCCTATATCATTTTCATCCCAAGTAGTGATATCTGTGAAATCACAGGTTTGATGTGTGCTAATT
2081 ATGTATTCTTCTAATACATATTAAAAGACATAACTATCAAAACAAAATAAATTTGTCTGTTTTCAACCAAAGAAGTCACG
2161 TACCACTGGTGGTACTGTGTGCCATAATTTGGCAAATGCTGGCCTTTATGGACGAGCACAATTCGGGGGTCAGACCTGGT
2241 TCAAATTCTAGCTGTAGAAACTTGTGCAAGTTACTTCACCTCTGAGCCTAAGTTTCCACATCTGTAAAAGGAGATAATAA
2321 ACACCTACCTTGCAGTAGTGAAGCAAAGAGAAAATTAAATATATATGAAGCAATTTGGCTGGCATCTAGATCATTCACAG
2401 CCCTTTAAAGGTCACCTTTGCTGTTCTCCCCACTTTACAGATAAGGAAACTGAGGCCCAAAAAGGTTTGAACCCAGGTCT
2481 TCCAAGTCATTCAAGTGCTTTCTCCACTGTACAGGTGGTTATCAACCTTGGCTGCGCATCAGAATCGTTTGTAAAGCTTT
2561 TTCTTTTTCCTTTTTAAAAAGTAAAGCAATATATACACAGGTAAAAAAATAAAATAGTACAGAAGGGCTTATAATGAGAA
2641 GCAGCAGTTCCCTGCTTGCACCCCCACATCCAAAGGATGTGGAGCTCTTTAAAAATAAATTGCTCTGGTCCCACCTCTGG
2721 AAATCTGATTCAGCCAGCATGGATAATAACCCAGATAACTAACCCCTACCTCACAGGATAAAAAGGATTACATGAGATGC
2801 CTTAGGCTAAGGCCCTGGCACACAGGAACACATGTGCTACAAAGGAGCTTTGGGGACTTAAGTCCTGAGGATCCAGGAGG
2881 TGAGGTGACTTGTCCAAGATTCCACTGGTTTAGTGGCAGAGCCTAGACTTCCACTCGGATCTATTTAGTGCTTGCCCCCT
2961 GCTCTCTCCTGTCGTGCCCCACCACCTCCTGGCATCACAGGGCAACCGTTGTCAAGGCTATGCTCACGGGAGGCTGGGCA
3041 CCACAGTGTTTCCAAGAGCAAGCTGGATCCGAGTAGATTCCCTAGGGCTTGTTGGAGGAACTAGTTTGACTCCCTTATAC
3121 TGTGGACGCAGTAGCCTTGCTGTAGGGAGTTGAAGAGTACTCCACAACAGTATCTTAAGTTTAACTGGGCACTTCCCTCT
3201 GGAAATCACAGTGTTGTGCACCAGGAACACAAAGATGAGTCAAATCTTTATCCTGCCTTTGAGGAGCTCACTGTTTAGTT
3281 GGGGAAACCATTTGTAAAACAGCCATTAACCATACAGTGTGATCAACACTGACAGGAGCACAGGAAAAACATCTAGCTTA
3361 TGTGAAGATTCAGAGAAGGCATCCTGTAGTCTAGGTGGTGATACCTGAACTGAGTCTTGAGGGACGGGTAGGAATTAGCC
3441 AGTTGAGGAAGTAGAAGGAATTTCCAGATATTGGAAACAGTATGCATGAAGACATGAAGGCAAGAAACAGCAAAACAAAT
3521 ACTGAAGCATGAAGATTCCTGGGGTGGGGGGAAAGCAGCAAGAAAAGGTAGAGAGGAACCAGATTGGAAGAGGGTCGTAA
3601 ATGCATGGCTACAGAATTCAGATTTGTTTTGTAGGACAGTGTGGTTCCCAAACTGGCTGTATACCACAAACAGGTACGGC
3681 ATTCTGGGCCCCGGCCCCTAAAACATTCATTAAGTCTGGGGTGAAGATTTGGAATCTTGAATGCTTATAAAGGTTACCAC
3761 ATGACTAGGGTACAGCCAGATTTGGAAACCATAGCTTGAAGGCAGTGAGGGAGCCATGAAATGGTTTTTAATAGGGGGAC
3841 TCCAGATCAGATGTGAACTTAACCTGTTTCTGGCTGGCTAGCCAACCAGCATGGAAAACAGATTAGGTTAGATGTTCATG
3921 CTGTATGTGCCCGTGCCTGTAGCTTCCCTGTTAATCAGCTTCTTACACTACTATATTTGCTTATTTTGTCTCTGAATAAG
4001 CTTTAGGCACCACAAGGGTGGGCCTGGGGATATTTTGCTTACCAGTATAGCCCCTGCAAAAAAGCACAGTGCCTGACACA
4081 AAACAGGCACCCAGTAAAGTTTTTGAATGAATGAATGCATGAGTGAATCCATTTGTGAGAGAGCGAATGGAGATGACAAG
4161 ATTAGCTAGGAGACTGGAAAAAGACCAGGAGGCCTGCACTAGGGCAAAGGCCAGTAGGAATAGATTGGAGGTGTTAAGGT
4241 GTGAACTGTTAAGGTAAGATGATAACTTAATGACTGATTATTGGATGTGGAGGGTGACTGAGAGGATAGAATGAGTACCC
4321 ATGAATAGCCATGATTCCTACCCTGTCCCAGTCATCTCTTTCCTTATCCATCTCTGAAACAATCTGCTTACATCCTCCTC
4401 AGCAACTGGAATTCCTCAAGTTAGTTAGACATTCTGTGTGCTGTGTGGTCTCTCACTGCCCCCCCACTCCCCACCCCTCC
4481 ACAAGCCATTGATTCATTCATCCAGTTCAATAAATCTTGGCTAAGCACCTCCAGTGTGCAGTAAGGCTCTTCCAAGCCAG
4561 GACTCTGACTCCCTCTTTCCTACCTCAAGAGATGTTTTTGAGGGCTTTCCCAGGTAAGAGTCACATCTCTTATACAATAA
4641 CTTATAGTGAGATACCCAGAATGTCAGACTTGTAAGGGAAGACTGCCCAAACCCCTTCTGAGGTCCTCAGAGGGGAATTA
4721 ACTTCCTAAGGTCCGACTGCTAGGAAGTGTTGGAGCCAGAAATGGAAGCTAGGTTTCCTTTCTATGTCATCTCTGGAGTC
4801 TTGATCTTGATCTATCCCATTGTAGATCAGGACAGGCAGAGGTGGTCAGGGAGAAGGTGGGACTTAGGTTGAACCTTGAA
4881 GGTCAATGTATTGGACAGGTCAAACAAGATGGTTGCCAATTACACTGCCCCCTTCTGGAAACCCTTAGCAAACCTGCCAT
4961 GCTTGCAGTCCCTTCTAAGGGGTTTCCTTAGCATAAGTTGCCATGCTCTGTACCATGTGACCTCACAATCCTGGCCACAG
5041 ATAGCTAGATGTGGATAGTGTCTGGTTCAAGGGCAACCAATCTCTAGGCTGGCCAGTGGCCTGTTAGCTGGACTGGCATA
5121 AGGACTTCACCTTACAGGGGTGGCATGTATCAAATGGCAAATGTATGAAACAACCAGATCTTTCAGGGAGGCAGAATGTG
5201 AGCTATTCAGAAGAAGTGAACGTTAATTAGAATTTAATGAGGCATTAGTGGTGGTGGATGAGGGGTGGCCAGAAACTAAA
5281 CAGCAAAAGCAAAGAGAAAGCTGCAGAAACCATAAGTAAGCAGAGGTCATGAGACATTTGTATAATGAGATCACGGAGCC
5361 ACAGGGTGGCAGAAGCCATGAAGCAGCAAGGCAACAATGGGCTAGAAGCCATGAAGCAATAGGAGCCACGAGGAACAGAA
5441 ACCGTGAGACAAAACTGACTATGAGATCCACAAAGCAGCAGAAGGCTTGAATAGATAAGATCATGAGACAGTAGAAGCGA
5521 TGAGACTGCAAGAACCACAAGGTAGCCAGAACCATGTGGCAACATGGCAACAGGAATGGAAGAGGCAGCAGGAGCTACAA
5601 TGCAGAAAAGCCATGGATTAATAGGAACTGAAGCGCCGGGAGCCATGAAGCTGCAGGACCCATGAGGCAGAAAAAGCCAT
5681 GGGCTAGCATCGAGGGGGGCAGAAAGAAGTTAGTCAGTAGCAGTAGGAGGAGTATAAATACAGCCAGAAAGGAGTTGAGT
5761 CACCAATTTGGGAAGCACTAGAGAAGGGAGCAACAGATGCCTGCAGCTGAGGGGGTGACAAGATAAGCCAGGCTCTAGAG
5841 CTGCTTTGGATCATGAACCATTTTCAAGTTTCTGTTCTTCCATGAGGCTGCCTGTGTAGCTGTTCTTGTCTTCCTTATTT
5921 CCCTGTGAATGCTTTAATAAATCCCCATCACTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aggauGGGUCCCGUGUCUACCCCGu 5'
               ::|||||||| |||||||: 
Target 5' aaagtTTCAGGGCACTGATGGGGTc 3'
 1124 - 1148 168.00 -31.80
2 
miRNA  3' agGAUGGGU-CCCGUGUCUACCCCGu 5'
            :| |:||   |:| | ||||||| 
Target 5' gtTTCCTCATCTGTA-AAATGGGGCt 3'
 902 - 926 150.00 -16.70
3 
miRNA  3' aggaUGG-GUCCCGU--GUC----UACCCCGu 5'
              ||| || ||:|  |||    ||| ||| 
Target 5' aagaACCACAAGGTAGCCAGAACCATGTGGCa 3'
 5530 - 5561 129.00 -16.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
159937 14 ClinVar
368588 41 ClinVar
368587 96 ClinVar
368586 348 ClinVar
368585 381 ClinVar
913859 488 ClinVar
913858 578 ClinVar
368584 626 ClinVar
368583 665 ClinVar
913857 675 ClinVar
368582 703 ClinVar
368581 825 ClinVar
913856 931 ClinVar
368580 1028 ClinVar
913480 1040 ClinVar
368579 1239 ClinVar
368578 1240 ClinVar
913479 1542 ClinVar
368577 1559 ClinVar
913478 1914 ClinVar
913477 1934 ClinVar
368576 1961 ClinVar
912346 1967 ClinVar
368575 2050 ClinVar
912345 2086 ClinVar
368574 2225 ClinVar
912344 2389 ClinVar
368573 2423 ClinVar
368572 2435 ClinVar
368571 2490 ClinVar
368570 2540 ClinVar
368569 2589 ClinVar
368568 2609 ClinVar
368567 2663 ClinVar
368566 2856 ClinVar
914546 2936 ClinVar
368565 2948 ClinVar
368564 2973 ClinVar
914545 3025 ClinVar
914544 3087 ClinVar
368563 3305 ClinVar
914543 3392 ClinVar
368562 3421 ClinVar
913428 3484 ClinVar
913427 3596 ClinVar
368561 3671 ClinVar
368560 3777 ClinVar
368559 3807 ClinVar
368558 3838 ClinVar
368557 3851 ClinVar
368556 4087 ClinVar
913067 4156 ClinVar
913066 4367 ClinVar
368555 4382 ClinVar
368554 4443 ClinVar
368553 4581 ClinVar
368552 4645 ClinVar
915027 4887 ClinVar
368551 4954 ClinVar
915026 4998 ClinVar
368550 5016 ClinVar
915025 5051 ClinVar
368549 5197 ClinVar
915024 5251 ClinVar
368548 5352 ClinVar
368547 5355 ClinVar
368546 5380 ClinVar
914506 5443 ClinVar
368545 5444 ClinVar
914505 5451 ClinVar
368544 5481 ClinVar
914504 5489 ClinVar
913393 5506 ClinVar
368543 5692 ClinVar
913392 5722 ClinVar
913391 5853 ClinVar
913390 5855 ClinVar
368542 5915 ClinVar
913389 5946 ClinVar
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs112727682 14 dbSNP
rs782000944 16 dbSNP
rs782643629 18 dbSNP
rs782233428 19 dbSNP
rs375982884 28 dbSNP
rs371618317 33 dbSNP
rs782548345 41 dbSNP
rs781902152 53 dbSNP
rs782035040 63 dbSNP
rs1033656379 82 dbSNP
rs1341530033 83 dbSNP
rs1368884454 89 dbSNP
rs1389104401 94 dbSNP
rs139317060 96 dbSNP
rs1335563013 97 dbSNP
rs1238892536 100 dbSNP
rs1286328151 112 dbSNP
rs970492899 113 dbSNP
rs1355167002 116 dbSNP
rs1219593861 128 dbSNP
rs1264392756 129 dbSNP
rs1022965180 145 dbSNP
rs782144152 150 dbSNP
rs1211625693 158 dbSNP
rs1248080938 160 dbSNP
rs1014388500 167 dbSNP
rs895867380 169 dbSNP
rs1179446751 175 dbSNP
rs1382421541 177 dbSNP
rs1443059396 183 dbSNP
rs1162971117 187 dbSNP
rs1350602874 188 dbSNP
rs1459849526 193 dbSNP
rs1036876646 194 dbSNP
rs1296965244 234 dbSNP
rs1396180639 248 dbSNP
rs782472357 252 dbSNP
rs1448014636 254 dbSNP
rs1311985718 255 dbSNP
rs1378617165 257 dbSNP
rs1243403641 259 dbSNP
rs1311373244 260 dbSNP
rs113484670 261 dbSNP
rs1321807569 270 dbSNP
rs1004427532 273 dbSNP
rs1223587685 278 dbSNP
rs1249575003 286 dbSNP
rs1457113680 290 dbSNP
rs1199012440 294 dbSNP
rs888265508 300 dbSNP
rs1460142954 303 dbSNP
rs781879292 311 dbSNP
rs6638390 315 dbSNP
rs1414547049 319 dbSNP
rs1425670553 322 dbSNP
rs1168894856 329 dbSNP
rs932575444 335 dbSNP
rs1466640167 340 dbSNP
rs782758415 344 dbSNP
rs782700234 348 dbSNP
rs782045927 349 dbSNP
rs1301900813 350 dbSNP
rs1379210354 353 dbSNP
rs1229556483 367 dbSNP
rs1292881992 368 dbSNP
rs184957599 381 dbSNP
rs1219242409 398 dbSNP
rs913641335 408 dbSNP
rs111801688 423 dbSNP
rs1259690937 426 dbSNP
rs1321163069 434 dbSNP
rs1209633908 458 dbSNP
rs1238293658 459 dbSNP
rs1484389063 465 dbSNP
rs1184826319 469 dbSNP
rs1262653673 471 dbSNP
rs142980499 487 dbSNP
rs956422392 488 dbSNP
rs1427556500 500 dbSNP
rs1414288083 506 dbSNP
rs1174854414 509 dbSNP
rs1359355856 539 dbSNP
rs1449823275 541 dbSNP
rs1286603797 546 dbSNP
rs782120341 549 dbSNP
rs1400468579 568 dbSNP
rs782796631 571 dbSNP
rs1343360460 572 dbSNP
rs926113176 573 dbSNP
rs782042924 578 dbSNP
rs1314160175 585 dbSNP
rs1213989720 593 dbSNP
rs868953226 596 dbSNP
rs1285325553 619 dbSNP
rs1057515970 626 dbSNP
rs1196416672 637 dbSNP
rs970295527 644 dbSNP
rs1267405906 647 dbSNP
rs1023009317 655 dbSNP
rs191977511 658 dbSNP
rs1057515969 665 dbSNP
rs1427774164 672 dbSNP
rs1415804526 675 dbSNP
rs992819122 681 dbSNP
rs1359309913 692 dbSNP
rs1419805207 693 dbSNP
rs960137486 698 dbSNP
rs189126241 703 dbSNP
rs1403531924 709 dbSNP
rs1329246402 711 dbSNP
rs1435757158 712 dbSNP
rs1275206693 717 dbSNP
rs1004273797 718 dbSNP
rs1369483433 728 dbSNP
rs1222211627 729 dbSNP
rs888287415 733 dbSNP
rs1354440321 752 dbSNP
rs782417885 767 dbSNP
rs1289731241 769 dbSNP
rs1451528718 805 dbSNP
rs370249510 816 dbSNP
rs1026782212 822 dbSNP
rs1057515968 825 dbSNP
rs1468957828 828 dbSNP
rs1176346950 856 dbSNP
rs1379283935 860 dbSNP
rs1439965571 875 dbSNP
rs1159930309 884 dbSNP
rs782624297 894 dbSNP
rs1404640008 899 dbSNP
rs997208102 907 dbSNP
rs899753029 920 dbSNP
rs1040715442 924 dbSNP
rs1444331920 930 dbSNP
rs782237045 931 dbSNP
rs892107977 944 dbSNP
rs1377884726 964 dbSNP
rs1052625510 968 dbSNP
rs781988044 987 dbSNP
rs936399382 991 dbSNP
rs926115967 992 dbSNP
rs782393286 997 dbSNP
rs978949172 1006 dbSNP
rs948981818 1009 dbSNP
rs1436630604 1010 dbSNP
rs916149568 1013 dbSNP
rs185417324 1021 dbSNP
rs1057515967 1028 dbSNP
rs1239242575 1035 dbSNP
rs782290445 1036 dbSNP
rs1180138061 1037 dbSNP
rs79382603 1040 dbSNP
rs1472195495 1045 dbSNP
rs1163719653 1047 dbSNP
rs1415847320 1067 dbSNP
rs1015571458 1071 dbSNP
rs1330415966 1072 dbSNP
rs983275424 1077 dbSNP
rs1449197654 1085 dbSNP
rs373131859 1087 dbSNP
rs1332480717 1090 dbSNP
rs952825771 1112 dbSNP
rs1339899774 1132 dbSNP
rs1448825568 1138 dbSNP
rs1286072768 1140 dbSNP
rs781917084 1145 dbSNP
rs1218624977 1151 dbSNP
rs1259045475 1158 dbSNP
rs192625201 1160 dbSNP
rs899784504 1161 dbSNP
rs1200095350 1176 dbSNP
rs1253667053 1179 dbSNP
rs1441537571 1188 dbSNP
rs1019508564 1189 dbSNP
rs1008070414 1191 dbSNP
rs1238767430 1199 dbSNP
rs782210534 1204 dbSNP
rs1052067414 1205 dbSNP
rs936455927 1207 dbSNP
rs782608322 1210 dbSNP
rs1467015461 1215 dbSNP
rs1170648213 1221 dbSNP
rs782502306 1239 dbSNP
rs1057515966 1240 dbSNP
rs1415328962 1269 dbSNP
rs1336233073 1273 dbSNP
rs1338536803 1279 dbSNP
rs1399865601 1284 dbSNP
rs1043644178 1293 dbSNP
rs868932212 1304 dbSNP
rs1342716060 1325 dbSNP
rs781867593 1329 dbSNP
rs1231494895 1336 dbSNP
rs993089408 1342 dbSNP
rs938877803 1350 dbSNP
rs1200730236 1351 dbSNP
rs908577323 1367 dbSNP
rs782210418 1381 dbSNP
rs1487023204 1387 dbSNP
rs1192793356 1391 dbSNP
rs982796125 1397 dbSNP
rs782789219 1410 dbSNP
rs952937090 1413 dbSNP
rs1196482631 1421 dbSNP
rs1376917030 1429 dbSNP
rs920005137 1437 dbSNP
rs1466693149 1450 dbSNP
rs1174542777 1463 dbSNP
rs1358660292 1479 dbSNP
rs1419196090 1481 dbSNP
rs975445485 1487 dbSNP
rs1298931842 1502 dbSNP
rs963859226 1509 dbSNP
rs76412438 1513 dbSNP
rs1019371736 1530 dbSNP
rs1362971616 1534 dbSNP
rs781783328 1542 dbSNP
rs956618472 1545 dbSNP
rs782736361 1559 dbSNP
rs1332049903 1579 dbSNP
rs1233433699 1585 dbSNP
rs1305213969 1586 dbSNP
rs782614066 1598 dbSNP
rs1215225375 1612 dbSNP
rs1286198940 1613 dbSNP
rs868918459 1622 dbSNP
rs1000522033 1647 dbSNP
rs1263547562 1652 dbSNP
rs903622147 1658 dbSNP
rs1201215964 1659 dbSNP
rs1044837018 1663 dbSNP
rs1439359517 1667 dbSNP
rs1159323747 1671 dbSNP
rs1382307507 1672 dbSNP
rs782498010 1674 dbSNP
rs1293461118 1684 dbSNP
rs782086149 1692 dbSNP
rs1057319848 1699 dbSNP
rs1388867560 1702 dbSNP
rs1329783956 1708 dbSNP
rs1374199714 1709 dbSNP
rs1239060369 1714 dbSNP
rs938950455 1716 dbSNP
rs908781931 1739 dbSNP
rs1318203123 1748 dbSNP
rs782390214 1751 dbSNP
rs1047531151 1770 dbSNP
rs1215300700 1771 dbSNP
rs1488793735 1771 dbSNP
rs1236208554 1785 dbSNP
rs931348451 1797 dbSNP
rs1179508765 1802 dbSNP
rs1410163866 1816 dbSNP
rs919892552 1826 dbSNP
rs1164629748 1831 dbSNP
rs1369525321 1832 dbSNP
rs1459960698 1861 dbSNP
rs1168970608 1868 dbSNP
rs1400050069 1878 dbSNP
rs975476459 1898 dbSNP
rs964056946 1914 dbSNP
rs1374817710 1915 dbSNP
rs1393770362 1927 dbSNP
rs1311438037 1934 dbSNP
rs912433431 1940 dbSNP
rs1235121950 1952 dbSNP
rs1255853916 1958 dbSNP
rs1057515965 1961 dbSNP
rs986586627 1961 dbSNP
rs782767897 1963 dbSNP
rs1199458329 1969 dbSNP
rs782746415 1996 dbSNP
rs1482426280 2024 dbSNP
rs1181352125 2045 dbSNP
rs1257026078 2048 dbSNP
rs1057515964 2050 dbSNP
rs782137665 2075 dbSNP
rs956863357 2081 dbSNP
rs1423309925 2084 dbSNP
rs1030897993 2085 dbSNP
rs1173339282 2086 dbSNP
rs782255931 2088 dbSNP
rs1464289001 2090 dbSNP
rs1301737928 2091 dbSNP
rs1001164920 2108 dbSNP
rs1416464735 2111 dbSNP
rs1276258406 2116 dbSNP
rs368386816 2129 dbSNP
rs1023685286 2133 dbSNP
rs1218987267 2148 dbSNP
rs1012044359 2157 dbSNP
rs782345534 2158 dbSNP
rs1274938944 2159 dbSNP
rs896230440 2160 dbSNP
rs188441757 2168 dbSNP
rs1256598556 2182 dbSNP
rs1486712813 2200 dbSNP
rs1057350556 2202 dbSNP
rs1003024760 2207 dbSNP
rs1263074577 2208 dbSNP
rs887250489 2212 dbSNP
rs1188650509 2218 dbSNP
rs1423577751 2221 dbSNP
rs1047323522 2225 dbSNP
rs1057515963 2225 dbSNP
rs1174919862 2226 dbSNP
rs1375475687 2228 dbSNP
rs1436062818 2235 dbSNP
rs782421219 2244 dbSNP
rs931523527 2248 dbSNP
rs1359787073 2265 dbSNP
rs782182247 2268 dbSNP
rs1271661052 2277 dbSNP
rs1365236849 2288 dbSNP
rs1218827223 2291 dbSNP
rs1302274041 2293 dbSNP
rs1350387384 2322 dbSNP
rs1214504637 2329 dbSNP
rs919941143 2365 dbSNP
rs1488895323 2370 dbSNP
rs1218573513 2379 dbSNP
rs114329529 2389 dbSNP
rs1488374448 2403 dbSNP
rs942821750 2415 dbSNP
rs1190219398 2420 dbSNP
rs147324052 2423 dbSNP
rs782650092 2435 dbSNP
rs782457976 2437 dbSNP
rs923738502 2443 dbSNP
rs979377727 2477 dbSNP
rs1379173213 2479 dbSNP
rs1401155308 2480 dbSNP
rs1320248513 2488 dbSNP
rs1057515962 2490 dbSNP
rs1347852908 2500 dbSNP
rs1435469193 2508 dbSNP
rs968368680 2514 dbSNP
rs142015270 2518 dbSNP
rs1373465270 2527 dbSNP
rs990472572 2532 dbSNP
rs960469776 2535 dbSNP
rs782655517 2536 dbSNP
rs182535846 2540 dbSNP
rs1354507398 2546 dbSNP
rs1005011637 2548 dbSNP
rs887290066 2551 dbSNP
rs1288370829 2576 dbSNP
rs782291666 2589 dbSNP
rs1222730318 2593 dbSNP
rs192734396 2609 dbSNP
rs1469488251 2610 dbSNP
rs1176404642 2614 dbSNP
rs1236995774 2617 dbSNP
rs1470218899 2617 dbSNP
rs898733912 2619 dbSNP
rs1411495194 2635 dbSNP
rs1404763375 2639 dbSNP
rs187544317 2640 dbSNP
rs1165359454 2644 dbSNP
rs1396427078 2646 dbSNP
rs1444749875 2659 dbSNP
rs1330968617 2661 dbSNP
rs1057515961 2663 dbSNP
rs1444432207 2678 dbSNP
rs1282536403 2684 dbSNP
rs1356251764 2694 dbSNP
rs1229410212 2702 dbSNP
rs1275372517 2703 dbSNP
rs1316483263 2706 dbSNP
rs1196316897 2708 dbSNP
rs1257004778 2714 dbSNP
rs1438091578 2717 dbSNP
rs1183353410 2721 dbSNP
rs1235303991 2725 dbSNP
rs781830199 2737 dbSNP
rs1039706657 2762 dbSNP
rs942684147 2768 dbSNP
rs1188571023 2770 dbSNP
rs782616518 2780 dbSNP
rs782519176 2784 dbSNP
rs1051136275 2793 dbSNP
rs1169758039 2826 dbSNP
rs935377192 2828 dbSNP
rs1411928890 2834 dbSNP
rs1328305844 2850 dbSNP
rs923839148 2851 dbSNP
rs148128199 2856 dbSNP
rs1339952241 2865 dbSNP
rs782800436 2877 dbSNP
rs1295679980 2884 dbSNP
rs1339163655 2890 dbSNP
rs1218377842 2899 dbSNP
rs1271210961 2902 dbSNP
rs1339646902 2904 dbSNP
rs1197194325 2907 dbSNP
rs1275809215 2925 dbSNP
rs782494133 2936 dbSNP
rs1259500533 2937 dbSNP
rs1476823264 2943 dbSNP
rs1192659139 2946 dbSNP
rs183355603 2948 dbSNP
rs781792401 2951 dbSNP
rs1476476937 2956 dbSNP
rs1171071144 2964 dbSNP
rs1401526519 2968 dbSNP
rs1435394171 2969 dbSNP
rs56110615 2973 dbSNP
rs782150991 2974 dbSNP
rs782095170 2987 dbSNP
rs1034651727 2993 dbSNP
rs149262531 3002 dbSNP
rs1328565604 3003 dbSNP
rs782033105 3008 dbSNP
rs782383302 3015 dbSNP
rs1272736586 3017 dbSNP
rs1346759306 3020 dbSNP
rs370363362 3021 dbSNP
rs1234342714 3023 dbSNP
rs782139355 3025 dbSNP
rs1281926799 3027 dbSNP
rs950516958 3028 dbSNP
rs1262121330 3030 dbSNP
rs1025844793 3043 dbSNP
rs996064812 3045 dbSNP
rs1448545205 3055 dbSNP
rs1196540911 3061 dbSNP
rs898773684 3067 dbSNP
rs1377252864 3070 dbSNP
rs1454924417 3071 dbSNP
rs781947350 3080 dbSNP
rs1378565274 3083 dbSNP
rs782024964 3087 dbSNP
rs868952873 3092 dbSNP
rs1007065861 3114 dbSNP
rs1419559334 3118 dbSNP
rs891131459 3127 dbSNP
rs1387530076 3128 dbSNP
rs1385428447 3144 dbSNP
rs1323357005 3149 dbSNP
rs1369781736 3168 dbSNP
rs190368599 3191 dbSNP
rs1304914980 3192 dbSNP
rs1350907215 3211 dbSNP
rs1238183374 3216 dbSNP
rs782191527 3244 dbSNP
rs1261218764 3261 dbSNP
rs1352799776 3271 dbSNP
rs1207843807 3276 dbSNP
rs1252211403 3286 dbSNP
rs1469033012 3302 dbSNP
rs1057515960 3305 dbSNP
rs935466307 3307 dbSNP
rs1236387536 3310 dbSNP
rs1439185076 3338 dbSNP
rs1159982361 3341 dbSNP
rs1366021531 3350 dbSNP
rs902583811 3358 dbSNP
rs1043590645 3364 dbSNP
rs1456900550 3371 dbSNP
rs1163027026 3378 dbSNP
rs1395687695 3383 dbSNP
rs1441100226 3395 dbSNP
rs1327528989 3414 dbSNP
rs41304780 3421 dbSNP
rs782604110 3425 dbSNP
rs1390282241 3428 dbSNP
rs1307171342 3450 dbSNP
rs1337453586 3453 dbSNP
rs916389823 3471 dbSNP
rs1272241092 3478 dbSNP
rs1055055925 3483 dbSNP
rs1215730078 3484 dbSNP
rs1256368614 3489 dbSNP
rs1480450178 3497 dbSNP
rs1177847568 3500 dbSNP
rs1252822763 3521 dbSNP
rs35002054 3528 dbSNP
rs1422521618 3530 dbSNP
rs1187867127 3538 dbSNP
rs1463324531 3546 dbSNP
rs782367429 3546 dbSNP
rs939210614 3551 dbSNP
rs1169039081 3565 dbSNP
rs1397669806 3567 dbSNP
rs1461226162 3571 dbSNP
rs927653412 3573 dbSNP
rs1398018648 3593 dbSNP
rs782065369 3595 dbSNP
rs950524317 3597 dbSNP
rs920318490 3600 dbSNP
rs1356062996 3601 dbSNP
rs1234867323 3609 dbSNP
rs1276139891 3629 dbSNP
rs1307123265 3653 dbSNP
rs1205506194 3660 dbSNP
rs973151780 3668 dbSNP
rs1057515959 3671 dbSNP
rs782246439 3677 dbSNP
rs962861729 3679 dbSNP
rs1210322235 3690 dbSNP
rs185811039 3692 dbSNP
rs183780691 3693 dbSNP
rs191172316 3708 dbSNP
rs1427490585 3712 dbSNP
rs782569064 3716 dbSNP
rs1018362067 3717 dbSNP
rs1355720860 3720 dbSNP
rs1464084610 3729 dbSNP
rs1311784107 3730 dbSNP
rs1375985096 3739 dbSNP
rs1007137991 3742 dbSNP
rs782454474 3752 dbSNP
rs1296052773 3755 dbSNP
rs1361014750 3765 dbSNP
rs41315082 3777 dbSNP
rs1297971079 3778 dbSNP
rs1029694222 3794 dbSNP
rs1057515958 3807 dbSNP
rs1310709822 3814 dbSNP
rs1233653696 3822 dbSNP
rs1281202252 3831 dbSNP
rs1486908925 3832 dbSNP
rs1215099099 3833 dbSNP
rs144702614 3838 dbSNP
rs1486412196 3839 dbSNP
rs902490253 3848 dbSNP
rs1044213426 3849 dbSNP
rs782817464 3851 dbSNP
rs1452254294 3864 dbSNP
rs1172457262 3887 dbSNP
rs894983754 3899 dbSNP
rs1436435847 3904 dbSNP
rs1156873119 3905 dbSNP
rs1344335118 3907 dbSNP
rs782125552 3918 dbSNP
rs939284015 3926 dbSNP
rs927851381 3927 dbSNP
rs1431158229 3929 dbSNP
rs1290484663 3932 dbSNP
rs140798491 3933 dbSNP
rs1304174073 3935 dbSNP
rs1350191186 3937 dbSNP
rs782679175 3953 dbSNP
rs782816351 3955 dbSNP
rs782041619 3962 dbSNP
rs781929567 3963 dbSNP
rs1245398884 3992 dbSNP
rs1466816433 3994 dbSNP
rs1192624071 4018 dbSNP
rs1253035175 4029 dbSNP
rs782184435 4045 dbSNP
rs973566573 4046 dbSNP
rs782431552 4065 dbSNP
rs137904273 4066 dbSNP
rs911427714 4070 dbSNP
rs1407160691 4084 dbSNP
rs1401274086 4086 dbSNP
rs1057515957 4087 dbSNP
rs985582933 4088 dbSNP
rs782108073 4093 dbSNP
rs1326856046 4118 dbSNP
rs1461085565 4118 dbSNP
rs955645909 4123 dbSNP
rs1444613298 4143 dbSNP
rs1279104622 4144 dbSNP
rs782600935 4145 dbSNP
rs1225985684 4150 dbSNP
rs999754790 4156 dbSNP
rs1334648123 4157 dbSNP
rs1212624370 4170 dbSNP
rs967121793 4205 dbSNP
rs1273400072 4209 dbSNP
rs1469589134 4222 dbSNP
rs1022257332 4223 dbSNP
rs1179031974 4226 dbSNP
rs1231827764 4230 dbSNP
rs1470433974 4238 dbSNP
rs782468967 4242 dbSNP
rs782231289 4253 dbSNP
rs895223742 4254 dbSNP
rs1054992303 4257 dbSNP
rs1165434880 4259 dbSNP
rs781995748 4272 dbSNP
rs1396952068 4279 dbSNP
rs782669146 4279 dbSNP
rs1355779982 4280 dbSNP
rs1408485423 4283 dbSNP
rs1328192374 4305 dbSNP
rs1190328887 4306 dbSNP
rs373112346 4315 dbSNP
rs1355190519 4321 dbSNP
rs1444942291 4361 dbSNP
rs1003358509 4367 dbSNP
rs1057515956 4382 dbSNP
rs906340789 4382 dbSNP
rs1234279602 4383 dbSNP
rs1048119732 4395 dbSNP
rs1295564541 4401 dbSNP
rs1336421954 4410 dbSNP
rs1193723926 4414 dbSNP
rs782390611 4420 dbSNP
rs782630117 4443 dbSNP
rs782280038 4452 dbSNP
rs1255285386 4455 dbSNP
rs782032544 4456 dbSNP
rs1485340404 4458 dbSNP
rs1419774519 4459 dbSNP
rs1474509468 4460 dbSNP
rs898826956 4464 dbSNP
rs1037323768 4465 dbSNP
rs1311183040 4466 dbSNP
rs782186820 4466 dbSNP
rs1375360425 4469 dbSNP
rs1415952777 4470 dbSNP
rs1315100523 4473 dbSNP
rs1325082455 4478 dbSNP
rs1224734294 4481 dbSNP
rs1269209340 4487 dbSNP
rs1339712177 4494 dbSNP
rs1229973752 4496 dbSNP
rs1277641501 4521 dbSNP
rs782524803 4523 dbSNP
rs1485269958 4534 dbSNP
rs943153388 4543 dbSNP
rs1211509886 4546 dbSNP
rs782313027 4560 dbSNP
rs1445087923 4561 dbSNP
rs1192266469 4568 dbSNP
rs1242884330 4572 dbSNP
rs1476546614 4573 dbSNP
rs1057515955 4581 dbSNP
rs987159675 4612 dbSNP
rs1435843222 4623 dbSNP
rs1176107425 4634 dbSNP
rs1383500774 4637 dbSNP
rs150365487 4645 dbSNP
rs1319474696 4647 dbSNP
rs782603831 4650 dbSNP
rs1326638318 4655 dbSNP
rs1436844159 4672 dbSNP
rs922762466 4688 dbSNP
rs978752682 4702 dbSNP
rs782502026 4734 dbSNP
rs1234868142 4735 dbSNP
rs1257665201 4748 dbSNP
rs1348503552 4759 dbSNP
rs1022751311 4768 dbSNP
rs1284709998 4782 dbSNP
rs782665339 4784 dbSNP
rs151188026 4796 dbSNP
rs1252402530 4799 dbSNP
rs1454750134 4800 dbSNP
rs1195624174 4814 dbSNP
rs1362568589 4814 dbSNP
rs1453753802 4815 dbSNP
rs1159447196 4828 dbSNP
rs1387595896 4831 dbSNP
rs1458449132 4842 dbSNP
rs1323505599 4870 dbSNP
rs1369850762 4882 dbSNP
rs782813945 4886 dbSNP
rs142173620 4887 dbSNP
rs369673179 4893 dbSNP
rs1333852286 4894 dbSNP
rs1238249864 4908 dbSNP
rs1261054472 4915 dbSNP
rs906365701 4919 dbSNP
rs1026106486 4924 dbSNP
rs1211643262 4925 dbSNP
rs1272751277 4943 dbSNP
rs1057515954 4954 dbSNP
rs782700101 4954 dbSNP
rs1211706228 4958 dbSNP
rs1248519957 4959 dbSNP
rs1418933637 4965 dbSNP
rs1165365966 4989 dbSNP
rs1183202322 4993 dbSNP
rs993859451 4997 dbSNP
rs899071356 4998 dbSNP
rs1474417480 5003 dbSNP
rs782475308 5011 dbSNP
rs1164706679 5014 dbSNP
rs17002602 5016 dbSNP
rs781806401 5019 dbSNP
rs782768969 5022 dbSNP
rs782138660 5041 dbSNP
rs1294707873 5048 dbSNP
rs1393732071 5050 dbSNP
rs1390702768 5065 dbSNP
rs1307592564 5068 dbSNP
rs1352306419 5079 dbSNP
rs888755135 5080 dbSNP
rs1292515819 5110 dbSNP
rs782025891 5137 dbSNP
rs1335656852 5142 dbSNP
rs1247261045 5155 dbSNP
rs1249644594 5160 dbSNP
rs1480360706 5173 dbSNP
rs186735948 5177 dbSNP
rs782050365 5197 dbSNP
rs1485015290 5202 dbSNP
rs180727310 5203 dbSNP
rs1187660245 5205 dbSNP
rs922802112 5206 dbSNP
rs1419038159 5208 dbSNP
rs1475308274 5210 dbSNP
rs781850642 5213 dbSNP
rs1371036816 5214 dbSNP
rs945646632 5221 dbSNP
rs782774002 5222 dbSNP
rs79951324 5237 dbSNP
rs1372319660 5239 dbSNP
rs1412876987 5243 dbSNP
rs782340453 5250 dbSNP
rs188308804 5251 dbSNP
rs782000680 5254 dbSNP
rs782403337 5258 dbSNP
rs1230188131 5268 dbSNP
rs1293670921 5291 dbSNP
rs782294863 5298 dbSNP
rs1228238430 5301 dbSNP
rs959371069 5312 dbSNP
rs1346270271 5321 dbSNP
rs1210836998 5325 dbSNP
rs1277601846 5336 dbSNP
rs1258598395 5339 dbSNP
rs1057515953 5352 dbSNP
rs1484430221 5354 dbSNP
rs782143840 5355 dbSNP
rs1259231963 5356 dbSNP
rs1427620214 5359 dbSNP
rs782027191 5368 dbSNP
rs186354950 5380 dbSNP
rs1026596338 5394 dbSNP
rs1172956796 5401 dbSNP
rs1376043814 5412 dbSNP
rs1449913088 5419 dbSNP
rs1286968830 5429 dbSNP
rs1361512283 5430 dbSNP
rs375348750 5443 dbSNP
rs181871602 5444 dbSNP
rs782308559 5451 dbSNP
rs1368900102 5461 dbSNP
rs898972697 5461 dbSNP
rs1281632600 5463 dbSNP
rs782177735 5463 dbSNP
rs1314536928 5465 dbSNP
rs1214078572 5473 dbSNP
rs147896900 5481 dbSNP
rs1007398058 5489 dbSNP
rs888784616 5504 dbSNP
rs1188835082 5518 dbSNP
rs367855644 5519 dbSNP
rs997709319 5529 dbSNP
rs902918356 5538 dbSNP
rs1452007217 5552 dbSNP
rs1042972507 5571 dbSNP
rs945583452 5574 dbSNP
rs1192506462 5597 dbSNP
rs1425777343 5601 dbSNP
rs1416158732 5612 dbSNP
rs915382322 5623 dbSNP
rs189564109 5627 dbSNP
rs1344392697 5634 dbSNP
rs1457922527 5635 dbSNP
rs1054045988 5637 dbSNP
rs938202272 5655 dbSNP
rs1440257977 5662 dbSNP
rs1304336848 5666 dbSNP
rs1370290758 5673 dbSNP
rs1222572566 5677 dbSNP
rs1306692969 5681 dbSNP
rs926647721 5686 dbSNP
rs1269591297 5688 dbSNP
rs1057515952 5692 dbSNP
rs781973066 5694 dbSNP
rs1478930570 5709 dbSNP
rs185149202 5713 dbSNP
rs782799463 5719 dbSNP
rs782384271 5721 dbSNP
rs1161190814 5730 dbSNP
rs1392542256 5769 dbSNP
rs782559272 5777 dbSNP
rs1461136528 5788 dbSNP
rs781796695 5793 dbSNP
rs1324214425 5800 dbSNP
rs1351722530 5809 dbSNP
rs1440578601 5813 dbSNP
rs1298081205 5823 dbSNP
rs1230614640 5824 dbSNP
rs1374744244 5824 dbSNP
rs1291884734 5828 dbSNP
rs1332138048 5833 dbSNP
rs1232306280 5842 dbSNP
rs1289923605 5855 dbSNP
rs1452812842 5857 dbSNP
rs1201875900 5872 dbSNP
rs1232230355 5873 dbSNP
rs1483375786 5879 dbSNP
rs1184013556 5900 dbSNP
rs1057515951 5915 dbSNP
rs1415405151 5934 dbSNP
rs782503476 5943 dbSNP
rs972532010 5946 dbSNP
rs1164077323 5947 dbSNP
rs963253453 5955 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8243.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8243.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_006306 | 3UTR | AGUUUCCUCAUCUGUAAAAUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000322213.4 | 3UTR | CUAACAAUAUUACCUACCUCAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000322213.4 | 3UTR | CUAACAAUAUUACCUACCUCAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000322213.4 | 3UTR | CUAACAAUAUUACCUACCUCAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000322213.4 | 3UTR | UAAAAUGGGGCUAACAAUAUUACCUACCUCAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000322213.4 | 3UTR | CUAACAAUAUUACCUACCUCAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000322213.4 | 3UTR | AUGGGGCUAACAAUAUUACCUACCUCAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000322213.4 | 3UTR | CUAACAAUAUUACCUACCUCAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000322213.4 | 3UTR | CUAACAAUAUUACCUACCUCAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
54 hsa-miR-3189-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055405 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT263576 GHITM growth hormone inducible transmembrane protein 2 2
MIRT338983 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT404222 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT451745 CES3 carboxylesterase 3 2 2
MIRT454466 RBM14 RNA binding motif protein 14 2 8
MIRT477627 EFNA1 ephrin A1 2 2
MIRT495128 METTL24 methyltransferase like 24 2 2
MIRT496506 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT497260 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT501881 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT504586 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 4
MIRT505570 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT506759 KMT2D lysine methyltransferase 2D 2 2
MIRT512454 POLR3G RNA polymerase III subunit G 2 2
MIRT512716 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT514382 CLUAP1 clusterin associated protein 1 2 2
MIRT519861 ZFP62 ZFP62 zinc finger protein 2 6
MIRT525670 NHLRC4 NHL repeat containing 4 2 2
MIRT526359 TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 2 2
MIRT526656 PRSS42 protease, serine 42 2 4
MIRT527017 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT532190 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT533223 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT543161 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT552228 SART3 squamous cell carcinoma antigen recognized by T-cells 3 2 2
MIRT552719 YTHDC1 YTH domain containing 1 2 2
MIRT556873 IVNS1ABP influenza virus NS1A binding protein 2 2
MIRT558255 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT563105 IFRD2 interferon related developmental regulator 2 2 2
MIRT565436 SURF4 surfeit 4 2 2
MIRT568459 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT572804 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT576203 Baz2a bromodomain adjacent to zinc finger domain, 2A 2 2
MIRT623519 KCNK10 potassium two pore domain channel subfamily K member 10 2 2
MIRT637006 HHAT hedgehog acyltransferase 2 2
MIRT643668 WDR5 WD repeat domain 5 2 2
MIRT647472 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT650823 LZTR1 leucine zipper like transcription regulator 1 2 2
MIRT657377 HMGA1 high mobility group AT-hook 1 2 2
MIRT685077 HPSE heparanase 2 2
MIRT687565 MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 2 2
MIRT696101 SETD1A SET domain containing 1A 2 2
MIRT704887 CCND1 cyclin D1 2 2
MIRT709133 GLG1 golgi glycoprotein 1 2 2
MIRT709189 SAPCD2 suppressor APC domain containing 2 2 2
MIRT713407 PEX16 peroxisomal biogenesis factor 16 2 2
MIRT713467 SLC22A12 solute carrier family 22 member 12 2 2
MIRT714544 COL14A1 collagen type XIV alpha 1 chain 2 2
MIRT716953 TFAP2B transcription factor AP-2 beta 2 2
MIRT717325 PGK1 phosphoglycerate kinase 1 2 2
MIRT718252 ZDHHC8 zinc finger DHHC-type containing 8 2 2
MIRT718522 WDR33 WD repeat domain 33 2 2
MIRT723002 FADS1 fatty acid desaturase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3189 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-3189-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-3189-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3189-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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