pre-miRNA Information | |
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pre-miRNA | hsa-mir-7107 |
Genomic Coordinates | chr12: 121444273 - 121444352 |
Description | Homo sapiens miR-7107 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-7107-5p | ||||||||||||||||||||||||||||||
Sequence | 6| UCGGCCUGGGGAGGAGGAAGGG |27 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Meta-analysis | ||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SERTAD3 | ||||||||||||||||||||
Synonyms | RBT1 | ||||||||||||||||||||
Description | SERTA domain containing 3 | ||||||||||||||||||||
Transcript | NM_013368 | ||||||||||||||||||||
Other Transcripts | NM_203344 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SERTAD3 | |||||||||||||||||||||
3'UTR of SERTAD3 (miRNA target sites are highlighted) |
>SERTAD3|NM_013368|3'UTR 1 AACTGTGATAGAGGGGATCGATCCTTCCTCATGTCATCTTCGGTGGCCTGGATCCCTGAATGCAACTCTGGGTGTGTGTT 81 TTTGTGGGGGCTCGAAGCAGTGACTATGGCCTCCTTTGTTCCCATTTCAGGGTTCCACAAACTGTCTTGCATGTGTGTGT 161 GTGTCTGGTTACCCCGACCTTCTGTGAAGGTGGGTCTTCCTGAATTAATTTATCTATTCCAAATGCCTTAACGAGACTCT 241 GTTTCTGGGAGTCTGATTTTCCACTTACACATTTCTTCCACCTTTCCTGCTAGTTCCCACTCCCCTGTGACCACTGGGGC 321 CTCAGGGAAGATAAAGAAAGCTGGGCCTGTCGAAGGATGACAGGGATGTGCTGCCAGGTTGCTATAGAAACCCAGGCTCT 401 GCCTCTTGCACCTTGAGGGGGTGGGAGGGGCTGGTGTCCTCCCTCCAGGCTGAACCCCACTTCCTCGGCAGGACCCCAGT 481 CTCAGCAGCCTCCTGATTTCATAACCAGGCCGGACCACGTGCAATAGGGTGGAAACCAAACTGCTCCATGCCGGGTTATT 561 TAAAAGAAAGGCAGAGTTTGTGGTGGCTTTTTTTTTTTTTTTTGGATTGTTTGTAATTTTTTTAAATAAAAGTATTTTGG 641 AAGGAGGGAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 29946.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1
"PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 29946.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM714645 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repB |
Location of target site | ENST00000392028.4 | 3UTR | AUUUCAUAACCAGGCCGGACCACGUGCAAUAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM714646 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / mildMNase, repA |
Location of target site | ENST00000392028.4 | 3UTR | AUUUCAUAACCAGGCCGGACCACGUGCAAUAGGGUGG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM1065668 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_7 |
Location of target site | ENST00000392028.4 | 3UTR | AUUUCAUAACCAGGCCGGACCACGUGCAAUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000392028.4 | 3UTR | AUUUCAUAACCAGGCCGGACCACGUGCAAUAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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144 hsa-miR-7107-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT060580 | CCND1 | cyclin D1 | 2 | 4 | ||||||||
MIRT451035 | ZNF610 | zinc finger protein 610 | 2 | 2 | ||||||||
MIRT485711 | CASP16 | caspase 16, pseudogene | 2 | 8 | ||||||||
MIRT488402 | TDRKH | tudor and KH domain containing | 2 | 2 | ||||||||
MIRT492084 | TCF21 | transcription factor 21 | 2 | 2 | ||||||||
MIRT504213 | VAV3 | vav guanine nucleotide exchange factor 3 | 2 | 13 | ||||||||
MIRT505723 | SERTAD3 | SERTA domain containing 3 | 2 | 4 | ||||||||
MIRT509007 | FBXO6 | F-box protein 6 | 2 | 2 | ||||||||
MIRT509843 | FOS | Fos proto-oncogene, AP-1 transcription factor subunit | 2 | 2 | ||||||||
MIRT514761 | RBM4B | RNA binding motif protein 4B | 2 | 2 | ||||||||
MIRT515664 | LRRC27 | leucine rich repeat containing 27 | 2 | 2 | ||||||||
MIRT516316 | F8A2 | coagulation factor VIII associated 2 | 2 | 2 | ||||||||
MIRT516342 | F8A3 | coagulation factor VIII associated 3 | 2 | 2 | ||||||||
MIRT517139 | KCTD21 | potassium channel tetramerization domain containing 21 | 2 | 2 | ||||||||
MIRT518746 | C1orf35 | chromosome 1 open reading frame 35 | 2 | 2 | ||||||||
MIRT519299 | MLH1 | mutL homolog 1 | 2 | 2 | ||||||||
MIRT521527 | QSOX1 | quiescin sulfhydryl oxidase 1 | 2 | 4 | ||||||||
MIRT531756 | TXK | TXK tyrosine kinase | 2 | 2 | ||||||||
MIRT542208 | C14orf142 | GON7, KEOPS complex subunit homolog | 2 | 2 | ||||||||
MIRT542235 | FUT9 | fucosyltransferase 9 | 2 | 2 | ||||||||
MIRT542791 | PLEKHA3 | pleckstrin homology domain containing A3 | 2 | 2 | ||||||||
MIRT554378 | SETD5 | SET domain containing 5 | 2 | 2 | ||||||||
MIRT569908 | PCSK9 | proprotein convertase subtilisin/kexin type 9 | 2 | 2 | ||||||||
MIRT570222 | SLC27A1 | solute carrier family 27 member 1 | 2 | 2 | ||||||||
MIRT570976 | RGS19 | regulator of G protein signaling 19 | 2 | 2 | ||||||||
MIRT573046 | SHMT1 | serine hydroxymethyltransferase 1 | 2 | 2 | ||||||||
MIRT574954 | Vav3 | vav 3 oncogene | 2 | 8 | ||||||||
MIRT609297 | MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2 | 2 | ||||||||
MIRT612990 | GBX2 | gastrulation brain homeobox 2 | 2 | 2 | ||||||||
MIRT613851 | SHB | SH2 domain containing adaptor protein B | 2 | 2 | ||||||||
MIRT613935 | POLR3A | RNA polymerase III subunit A | 2 | 2 | ||||||||
MIRT614243 | WDR53 | WD repeat domain 53 | 2 | 4 | ||||||||
MIRT615158 | SPIB | Spi-B transcription factor | 2 | 2 | ||||||||
MIRT616145 | HS3ST1 | heparan sulfate-glucosamine 3-sulfotransferase 1 | 2 | 2 | ||||||||
MIRT616389 | C1orf87 | chromosome 1 open reading frame 87 | 2 | 2 | ||||||||
MIRT617737 | ATCAY | ATCAY, caytaxin | 2 | 4 | ||||||||
MIRT621449 | TCN2 | transcobalamin 2 | 2 | 2 | ||||||||
MIRT625784 | GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | 2 | 2 | ||||||||
MIRT628556 | MELK | maternal embryonic leucine zipper kinase | 2 | 2 | ||||||||
MIRT632041 | ZNF430 | zinc finger protein 430 | 2 | 2 | ||||||||
MIRT634937 | GTF2H2C | GTF2H2 family member C | 2 | 4 | ||||||||
MIRT637208 | MEAF6 | MYST/Esa1 associated factor 6 | 2 | 2 | ||||||||
MIRT637610 | LOH12CR1 | BLOC-1 related complex subunit 5 | 2 | 2 | ||||||||
MIRT637832 | CACNG8 | calcium voltage-gated channel auxiliary subunit gamma 8 | 2 | 2 | ||||||||
MIRT638107 | ZBTB43 | zinc finger and BTB domain containing 43 | 2 | 2 | ||||||||
MIRT638387 | RAB11FIP1 | RAB11 family interacting protein 1 | 2 | 2 | ||||||||
MIRT641689 | SPCS1 | signal peptidase complex subunit 1 | 2 | 2 | ||||||||
MIRT642611 | APOPT1 | apoptogenic 1, mitochondrial | 2 | 2 | ||||||||
MIRT643850 | LACTB | lactamase beta | 2 | 4 | ||||||||
MIRT649575 | PALD1 | phosphatase domain containing, paladin 1 | 2 | 2 | ||||||||
MIRT649860 | WDR12 | WD repeat domain 12 | 2 | 2 | ||||||||
MIRT651026 | ZNF699 | zinc finger protein 699 | 2 | 2 | ||||||||
MIRT652336 | TMOD3 | tropomodulin 3 | 2 | 4 | ||||||||
MIRT653286 | SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 2 | 2 | ||||||||
MIRT656292 | METTL14 | methyltransferase like 14 | 2 | 2 | ||||||||
MIRT656458 | MAPK14 | mitogen-activated protein kinase 14 | 2 | 2 | ||||||||
MIRT659539 | CHCHD5 | coiled-coil-helix-coiled-coil-helix domain containing 5 | 2 | 2 | ||||||||
MIRT661537 | NWD1 | NACHT and WD repeat domain containing 1 | 2 | 2 | ||||||||
MIRT668042 | GTPBP10 | GTP binding protein 10 | 2 | 2 | ||||||||
MIRT668147 | GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | 2 | 2 | ||||||||
MIRT668800 | CYP20A1 | cytochrome P450 family 20 subfamily A member 1 | 2 | 2 | ||||||||
MIRT669818 | STOML1 | stomatin like 1 | 2 | 2 | ||||||||
MIRT670490 | DCUN1D2 | defective in cullin neddylation 1 domain containing 2 | 2 | 2 | ||||||||
MIRT670615 | NPHP1 | nephrocystin 1 | 2 | 2 | ||||||||
MIRT670892 | CYTIP | cytohesin 1 interacting protein | 2 | 2 | ||||||||
MIRT670943 | LIPG | lipase G, endothelial type | 2 | 2 | ||||||||
MIRT671268 | MTRNR2L5 | MT-RNR2-like 5 | 2 | 2 | ||||||||
MIRT671903 | GBP4 | guanylate binding protein 4 | 2 | 2 | ||||||||
MIRT672239 | ABHD15 | abhydrolase domain containing 15 | 2 | 2 | ||||||||
MIRT672326 | C9orf3 | chromosome 9 open reading frame 3 | 2 | 2 | ||||||||
MIRT673113 | MFSD2A | major facilitator superfamily domain containing 2A | 2 | 2 | ||||||||
MIRT674412 | GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 2 | 2 | ||||||||
MIRT677718 | IRF1 | interferon regulatory factor 1 | 2 | 2 | ||||||||
MIRT678585 | PPP1R3B | protein phosphatase 1 regulatory subunit 3B | 2 | 2 | ||||||||
MIRT678726 | SRCAP | Snf2 related CREBBP activator protein | 2 | 2 | ||||||||
MIRT679338 | ISG20L2 | interferon stimulated exonuclease gene 20 like 2 | 2 | 2 | ||||||||
MIRT679614 | RRP36 | ribosomal RNA processing 36 | 2 | 2 | ||||||||
MIRT679695 | SLC1A5 | solute carrier family 1 member 5 | 2 | 4 | ||||||||
MIRT679715 | RPL24 | ribosomal protein L24 | 2 | 2 | ||||||||
MIRT680065 | CD96 | CD96 molecule | 2 | 2 | ||||||||
MIRT683379 | ESR2 | estrogen receptor 2 | 2 | 2 | ||||||||
MIRT683683 | MICA | MHC class I polypeptide-related sequence A | 2 | 2 | ||||||||
MIRT683865 | OCIAD1 | OCIA domain containing 1 | 2 | 2 | ||||||||
MIRT684073 | TLR7 | toll like receptor 7 | 2 | 2 | ||||||||
MIRT684126 | CEP104 | centrosomal protein 104 | 2 | 2 | ||||||||
MIRT684485 | GPR137B | G protein-coupled receptor 137B | 2 | 2 | ||||||||
MIRT684736 | DNAJB13 | DnaJ heat shock protein family (Hsp40) member B13 | 2 | 2 | ||||||||
MIRT684778 | MYO1F | myosin IF | 2 | 2 | ||||||||
MIRT685028 | MRI1 | methylthioribose-1-phosphate isomerase 1 | 2 | 2 | ||||||||
MIRT685189 | DCTN5 | dynactin subunit 5 | 2 | 2 | ||||||||
MIRT685307 | ASB16 | ankyrin repeat and SOCS box containing 16 | 2 | 2 | ||||||||
MIRT685514 | MSH3 | mutS homolog 3 | 2 | 2 | ||||||||
MIRT685702 | BHMT2 | betaine--homocysteine S-methyltransferase 2 | 2 | 2 | ||||||||
MIRT685944 | PTGIS | prostaglandin I2 synthase | 2 | 2 | ||||||||
MIRT686311 | VPS53 | VPS53, GARP complex subunit | 2 | 2 | ||||||||
MIRT686686 | TIMM10 | translocase of inner mitochondrial membrane 10 | 2 | 2 | ||||||||
MIRT687641 | LRIF1 | ligand dependent nuclear receptor interacting factor 1 | 2 | 2 | ||||||||
MIRT687923 | HOOK3 | hook microtubule tethering protein 3 | 2 | 2 | ||||||||
MIRT688117 | GEMIN8 | gem nuclear organelle associated protein 8 | 2 | 2 | ||||||||
MIRT688460 | DNAJB4 | DnaJ heat shock protein family (Hsp40) member B4 | 2 | 2 | ||||||||
MIRT688629 | CRISPLD2 | cysteine rich secretory protein LCCL domain containing 2 | 2 | 2 | ||||||||
MIRT688823 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | 2 | 2 | ||||||||
MIRT689117 | ZBTB25 | zinc finger and BTB domain containing 25 | 2 | 2 | ||||||||
MIRT689166 | ZNF665 | zinc finger protein 665 | 2 | 2 | ||||||||
MIRT690070 | MBD1 | methyl-CpG binding domain protein 1 | 2 | 2 | ||||||||
MIRT690733 | IRAK4 | interleukin 1 receptor associated kinase 4 | 2 | 2 | ||||||||
MIRT691324 | KIAA1841 | KIAA1841 | 2 | 2 | ||||||||
MIRT691517 | ZNF682 | zinc finger protein 682 | 2 | 2 | ||||||||
MIRT691607 | IPP | intracisternal A particle-promoted polypeptide | 2 | 2 | ||||||||
MIRT692314 | RFK | riboflavin kinase | 2 | 2 | ||||||||
MIRT692376 | LY6G5B | lymphocyte antigen 6 family member G5B | 2 | 2 | ||||||||
MIRT692436 | METTL8 | methyltransferase like 8 | 2 | 2 | ||||||||
MIRT692782 | SYNPO2L | synaptopodin 2 like | 2 | 2 | ||||||||
MIRT693136 | THEM4 | thioesterase superfamily member 4 | 2 | 2 | ||||||||
MIRT693422 | TECPR2 | tectonin beta-propeller repeat containing 2 | 2 | 2 | ||||||||
MIRT693871 | COX19 | COX19, cytochrome c oxidase assembly factor | 2 | 2 | ||||||||
MIRT694049 | PRIM1 | DNA primase subunit 1 | 2 | 2 | ||||||||
MIRT694092 | KIAA0930 | KIAA0930 | 2 | 2 | ||||||||
MIRT694190 | ZNF347 | zinc finger protein 347 | 2 | 2 | ||||||||
MIRT695177 | SLC25A33 | solute carrier family 25 member 33 | 2 | 2 | ||||||||
MIRT696180 | GNB5 | G protein subunit beta 5 | 2 | 2 | ||||||||
MIRT697387 | ZMAT3 | zinc finger matrin-type 3 | 2 | 2 | ||||||||
MIRT698924 | SPEM1 | spermatid maturation 1 | 2 | 2 | ||||||||
MIRT699314 | SLC35F5 | solute carrier family 35 member F5 | 2 | 4 | ||||||||
MIRT701106 | PAPD5 | poly(A) RNA polymerase D5, non-canonical | 2 | 2 | ||||||||
MIRT701575 | MYPN | myopalladin | 2 | 2 | ||||||||
MIRT701825 | MRPL37 | mitochondrial ribosomal protein L37 | 2 | 2 | ||||||||
MIRT702047 | METTL21A | methyltransferase like 21A | 2 | 2 | ||||||||
MIRT703034 | HAS2 | hyaluronan synthase 2 | 2 | 4 | ||||||||
MIRT704143 | DNAL1 | dynein axonemal light chain 1 | 2 | 2 | ||||||||
MIRT704759 | CDKN2AIPNL | CDKN2A interacting protein N-terminal like | 2 | 2 | ||||||||
MIRT705079 | C4orf29 | abhydrolase domain containing 18 | 2 | 2 | ||||||||
MIRT705346 | ATP1B3 | ATPase Na+/K+ transporting subunit beta 3 | 2 | 2 | ||||||||
MIRT706104 | ENTPD4 | ectonucleoside triphosphate diphosphohydrolase 4 | 2 | 2 | ||||||||
MIRT709070 | FAHD1 | fumarylacetoacetate hydrolase domain containing 1 | 2 | 2 | ||||||||
MIRT709534 | ZBED1 | zinc finger BED-type containing 1 | 2 | 2 | ||||||||
MIRT712356 | NAT14 | N-acetyltransferase 14 (putative) | 2 | 2 | ||||||||
MIRT713713 | PAOX | polyamine oxidase | 2 | 2 | ||||||||
MIRT714304 | ZNF454 | zinc finger protein 454 | 2 | 2 | ||||||||
MIRT714919 | PPP1R12C | protein phosphatase 1 regulatory subunit 12C | 2 | 2 | ||||||||
MIRT715792 | TBL3 | transducin beta like 3 | 2 | 2 | ||||||||
MIRT717376 | RBM41 | RNA binding motif protein 41 | 2 | 2 | ||||||||
MIRT719069 | ACOX1 | acyl-CoA oxidase 1 | 2 | 2 | ||||||||
MIRT724548 | HAUS2 | HAUS augmin like complex subunit 2 | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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