miRTarBase - #MIRT506235


—
pre-miRNA Information
pre-miRNA hsa-mir-6868   
Genomic Coordinates chr17: 76098019 - 76098076
Description Homo sapiens miR-6868 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6868-3p
Sequence 38| UUCCUUCUGUUGUCUGUGCAG |58
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM4415890 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1268215934 1 dbSNP
rs199573454 9 dbSNP
rs893365109 12 dbSNP
rs370367037 13 dbSNP
rs7208391 16 dbSNP
rs752026363 19 dbSNP
rs113525369 20 dbSNP
Putative Targets

Gene Information
Gene Symbol PEX13   
Synonyms NALD, PBD11A, PBD11B, ZWS
Description peroxisomal biogenesis factor 13
Transcript NM_002618   
Expression
Putative miRNA Targets on PEX13
3'UTR of PEX13
(miRNA target sites are highlighted)		 
>PEX13|NM_002618|3'UTR
   1 TATCTTTCATGTTTGCCTGCAGTTGAACAATACTTTAGAGTACTTTTTAAAATTATTTCTCACAAAGAAATGAATGTACA
  81 ATCCAATGAAAACATTTGTTATTGGCTATTTCAGGTGTTTTGCTGCTAGAAATTATTAAAGTTACACACTAGTATGTTGG
 161 TCTGGTGACCTGGTTACATTTTATTATACACATTATTGGACCATAAGGACATTTGTTTCACCTAGATTTTAAGATTATGG
 241 AGACTGCTGTCATTTTTATCTTATTTAAATCTCTAGGTTTATTGGAAGAGTAAGATTGATGAACTATAGCATGCACAGTT
 321 TGGTACAGTAGAGATCATTAATACTTTTAAAAGTTCTGCATTAATTGACTTGGAATCCTTAGAAATGGAGTGGTGACATG
 401 TCAGTATGAGAACAGGCAAAAGGTAAATTTTTTTTTTTTTTTACAACCTTAAGTAATCTCAATAATAAAATTTTCTGATC
 481 TGTATTATATCCAGTGTTGGGTTTATATTTTCACCCACAAACAACTGACACTGCTATCTTTTACTGTATTTTTAAAAATT
 561 TAATTTGAAAAGGTCACCCAGAAGCATTCTGAAGGAAATGGTTCTAGAATTATAGAGTATGTAGCCCTAATAGTTTTCCC
 641 TCCTAGCAAAAAGTCTGAAATTTATCTTTCTTACAAACTGTTCCATTTCTTCTAAGGATCCCTTAATTATTTATCTCTTT
 721 AAGCCAGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACCTGAGGTTGGGAGTT
 801 CAAGACCACCCTGACCAACATGGAGAAACCCCATCTTTACGAAAAATACAAAATTAGCTAGGTGTGGTGGCACATGCCTG
 881 TAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCCAGGAGGCGGAGGTTACGCTGAGCCGGAGATCT
 961 CGCCATTGCACTTCAGCCTGGGCAACAAAAGCGAAACTCCATCTCAAAAAATAAAATTATTTATTTCTTTAAAATATGAC
1041 TAGTTTTCATACTGGGTGAATCAGAAGTATATGAAAGGTATACTTTCTTTTCCTACAACAAATACTTGAGTTCTTTTGAG
1121 TTTGCACTTAATGATATAATCAGTTATAATAGTAATTTTTAATATTTTCATAGATTGTTTGCTTCTACCTTGTGTAATTT
1201 TTTAAATTCCATATTTAGGATGCTCTGTAAATATTGAAAATGTGTCACATTGGATACATTTTTCTTTTAGGTTTAGTTTT
1281 TACTACTGAGACTTATTTATAGTCTTAGTGCTCTATTGCCATTTAGAATATGATAATCCTCATGCCTTTAATCTCAGCAC
1361 TTTGGGAGGCCAAGGCGGGCGGATCACCTGCGGTCAGGAGTTTGAGACCAGCCTGGCCAACACGGTGAAACCCTGTCTCT
1441 ACTAAAAATACGAAAATTAGCTGGGTGCAGTGGCGTGCACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATC
1521 ACTTGAACCCGGGAGGCAGAGGTTGCAGGGAGCTGAGATCATGCCACTGCACTCCAGCCTAGGGGACAGAGCAAGACTCT
1601 GTCTCAAAACAAACAAACAAAAAATAATAATACGATAATGCTATTTGACGTGTTTTTTGGTTTATAATGATTTTAAATGC
1681 AGTTAACTTTCAGTACACTGAATATTTCCCCAGAAAATTGGAAACTTCATATACTTGGCTACGAACATACTACAGAGTAA
1761 TACTATCAGGAATACAGGTGTATAAGAATACATTTATAGATATTGTTGAAAACTTTGAACTGTTTGATAAAAATTGTGAT
1841 TTAGTATTTTTTCTTTTGTCTTTTTTTGAAACGGAGTCTCACTCTGTCGCCCAGGCTGGAGTCCAGTGGCGCGATCTCGG
1921 CTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCTGC
2001 CACCAGGCCCGGCTAATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCCATCTCCT
2081 GACCTCGTGATGAGCCCGCTTCGGTCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACCGCACCCAGCGATTTAGTATT
2161 TTTTTCTAATAGACTATGTTCAACAAATAAGTAATTCTCGAATAGTTCAGATTAAAACATACAGGAACCAAGTACATACC
2241 CAGCATAGAAGAACTTTACTAAAGGCTTCTTGGAAAGCCCTTTTTTGAAACGACAGTATCGTAAGTAACATATCATTTAT
2321 AATAGAAATCTTGACCCAGTGCAGAAAAATAAATATAGTAAAATTTATTTATCTTTGGCCAGTTTTCCAACACCCAGGTA
2401 TTAGCCTTGAAGTTGAAGAGATAAGGTTTCTTGTATATTATTTTTCATTTGTGTTCTACAATTAAAGGTTCTGCTTTGAT
2481 TTGTCAGATAATTTATAGAAATTTTGTTCTCAAAACAAATGTTTGATAAAACAGATTATTAAATTTGGGGTTGAGATGTC
2561 TAAATTGAATGCTAGAAGTAAAGTAGAAGTGACCACTATTAAAGATGTATAGGGAGAAGAGTACAGCACAAAGTGATAAA
2641 ATAGTGACACTTTTGTAGGGGTGTTTATTGTTTGGTTAAGTCTGCTAAATTACGGTATGCATTATCTGGTGACTATTTGT
2721 GCCTGAAAATTCGTTTTGTATTAAAATTCTGGAGAAGGAATTCAGGACTAGAATAAAGAGAAATTTTGTAACCTTTTTTA
2801 TCATGACAGTTTTAGAATAATTTTTTTAGCTGAGATTAAATGTTCAAGGCTCCAATATTATTTTTAGGAACTTATTTAAG
2881 GAGTGCTACTTTACAGAAATTACTAACACACCAAAACATTATTAATTAAATAAAATATAAGTTTACAATAATAAAACATG
2961 TTTCTTTTAATTTTTCTGATTATATTTTATGAGTTCAGAAAGGAAATGGTAAAAGAACTATACATTTTCATGTTTTAACA
3041 TTTTATGTACGTACTTGATTCTGTCTGTGTCATAATTACACATTTACTTGAACACAGCTATCCTTTATCTTGTGCTTTCT
3121 TTAATAGAAAAATGAACAGAAACTGAATGCAGTTAAATTTTTATTTTTAGTAGGTTGTGAAGTTACTTTTACTGGAGAAA
3201 TAAAAATATGTTAAACTTGAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacgUGUCUGUUGUCUUCCUu 5'
              | |  | : ||||||| 
Target 5' attaAAATTCTGGAGAAGGAa 3'
 2740 - 2760 141.00 -9.60
2 
miRNA  3' gaCGUGUCU--GU--UGUCUUCCUu 5'
            |:||| |  ||  |:||||| | 
Target 5' aaGTACATACCCAGCATAGAAGAAc 3'
 2230 - 2254 127.00 -9.40
3 
miRNA  3' gacGUGUCU--GU-UGUCUUCCUu 5'
             | ||||  ||  | |||||| 
Target 5' tcaCCCAGAAGCATTCTGAAGGAa 3'
 574 - 597 124.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
336672 91 ClinVar
896858 171 ClinVar
336673 217 ClinVar
336674 234 ClinVar
336675 264 ClinVar
336676 299 ClinVar
897355 319 ClinVar
897356 358 ClinVar
336677 359 ClinVar
336678 384 ClinVar
336679 428 ClinVar
897357 437 ClinVar
897358 447 ClinVar
336680 677 ClinVar
336681 776 ClinVar
336682 804 ClinVar
336683 814 ClinVar
898512 852 ClinVar
898513 896 ClinVar
336684 945 ClinVar
336685 953 ClinVar
895519 954 ClinVar
336686 957 ClinVar
895520 963 ClinVar
895521 1006 ClinVar
895522 1175 ClinVar
336687 1195 ClinVar
336688 1284 ClinVar
895523 1377 ClinVar
336689 1378 ClinVar
896923 1417 ClinVar
896924 1481 ClinVar
336690 1534 ClinVar
336691 1565 ClinVar
336692 1567 ClinVar
896925 1650 ClinVar
336693 1653 ClinVar
897420 1655 ClinVar
336694 1725 ClinVar
336695 1874 ClinVar
897421 1926 ClinVar
336696 1944 ClinVar
336697 1962 ClinVar
336698 1999 ClinVar
897422 2112 ClinVar
336699 2148 ClinVar
336700 2160 ClinVar
336701 2169 ClinVar
898587 2230 ClinVar
898588 2235 ClinVar
898589 2237 ClinVar
336702 2297 ClinVar
336703 2357 ClinVar
895596 2369 ClinVar
895597 2423 ClinVar
895598 2496 ClinVar
895599 2538 ClinVar
895600 2551 ClinVar
895601 2582 ClinVar
336704 2643 ClinVar
895602 2750 ClinVar
897004 2919 ClinVar
336705 2988 ClinVar
336706 3013 ClinVar
336707 3039 ClinVar
336708 3041 ClinVar
897005 3051 ClinVar
897006 3107 ClinVar
897007 3127 ClinVar
897008 3217 ClinVar
COSN28191427 3 COSMIC
COSN30517148 53 COSMIC
COSN30509620 62 COSMIC
COSN30130626 68 COSMIC
COSN24299006 98 COSMIC
COSN31516411 134 COSMIC
COSN31569387 155 COSMIC
COSN26556165 174 COSMIC
COSN20096740 443 COSMIC
COSN1849752 463 COSMIC
COSN21239681 957 COSMIC
COSN15710627 975 COSMIC
COSN9382269 1235 COSMIC
COSN7079063 1512 COSMIC
COSN22304435 1515 COSMIC
COSN14545294 2048 COSMIC
COSN29889083 2204 COSMIC
COSN9382270 2378 COSMIC
COSN1849753 2785 COSMIC
COSN31961654 3052 COSMIC
rs1177230 359 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1336569610 4 dbSNP
rs1281798845 10 dbSNP
rs760334205 18 dbSNP
rs762069334 20 dbSNP
rs767864122 23 dbSNP
rs539389012 29 dbSNP
rs759447524 31 dbSNP
rs1278633971 32 dbSNP
rs1319665986 37 dbSNP
rs1201696918 46 dbSNP
rs1015105512 49 dbSNP
rs1461704554 50 dbSNP
rs1323248561 60 dbSNP
rs1462732457 62 dbSNP
rs962163892 64 dbSNP
rs986003844 74 dbSNP
rs568893788 76 dbSNP
rs1409814020 82 dbSNP
rs1177743834 84 dbSNP
rs535967834 91 dbSNP
rs1252505129 94 dbSNP
rs1191797498 95 dbSNP
rs1470048108 102 dbSNP
rs770691305 103 dbSNP
rs1037922815 107 dbSNP
rs1315513989 130 dbSNP
rs969442986 139 dbSNP
rs929021678 146 dbSNP
rs981161712 150 dbSNP
rs199843645 163 dbSNP
rs548374776 170 dbSNP
rs77041272 171 dbSNP
rs774341751 180 dbSNP
rs928109342 184 dbSNP
rs759326400 189 dbSNP
rs1428133098 192 dbSNP
rs1346769532 199 dbSNP
rs1056744438 200 dbSNP
rs1180546646 202 dbSNP
rs1422077645 204 dbSNP
rs146980377 217 dbSNP
rs1455653623 219 dbSNP
rs767584678 224 dbSNP
rs1186182824 230 dbSNP
rs886056198 234 dbSNP
rs1170599062 237 dbSNP
rs913757434 241 dbSNP
rs1471008070 259 dbSNP
rs1044662257 261 dbSNP
rs558525565 264 dbSNP
rs1032242758 265 dbSNP
rs1358842340 279 dbSNP
rs1043678889 284 dbSNP
rs747780224 289 dbSNP
rs956161176 289 dbSNP
rs1363599995 291 dbSNP
rs1289301942 295 dbSNP
rs886056199 299 dbSNP
rs759687528 300 dbSNP
rs921163062 306 dbSNP
rs1314656874 309 dbSNP
rs1435220748 312 dbSNP
rs932377569 324 dbSNP
rs1051196741 328 dbSNP
rs776812844 336 dbSNP
rs1169794409 345 dbSNP
rs1426999992 357 dbSNP
rs138236564 358 dbSNP
rs1177230 359 dbSNP
rs963613938 360 dbSNP
rs1224862654 369 dbSNP
rs149099359 384 dbSNP
rs995401157 387 dbSNP
rs919062015 394 dbSNP
rs1207600147 401 dbSNP
rs1308952074 405 dbSNP
rs1295870131 409 dbSNP
rs1243420456 411 dbSNP
rs1488839195 416 dbSNP
rs1232233823 418 dbSNP
rs62150980 426 dbSNP
rs1353366931 428 dbSNP
rs201619544 428 dbSNP
rs761871965 428 dbSNP
rs77119785 429 dbSNP
rs1297745151 431 dbSNP
rs1460516236 442 dbSNP
rs554737021 447 dbSNP
rs1171657538 450 dbSNP
rs1261711509 461 dbSNP
rs1474980196 463 dbSNP
rs557090073 468 dbSNP
rs1190477921 470 dbSNP
rs1475859731 471 dbSNP
rs1250419889 473 dbSNP
rs758577707 495 dbSNP
rs1194528629 503 dbSNP
rs970041629 511 dbSNP
rs1002425926 515 dbSNP
rs1034986831 517 dbSNP
rs960671709 521 dbSNP
rs948429123 529 dbSNP
rs1294942245 538 dbSNP
rs988199496 544 dbSNP
rs1233668666 547 dbSNP
rs913976804 554 dbSNP
rs904801586 558 dbSNP
rs1392995526 560 dbSNP
rs936220445 569 dbSNP
rs1332067702 574 dbSNP
rs575650420 599 dbSNP
rs1461159476 613 dbSNP
rs1053307296 614 dbSNP
rs1392550504 630 dbSNP
rs766581293 631 dbSNP
rs574877101 643 dbSNP
rs1458749084 648 dbSNP
rs1363519973 662 dbSNP
rs886056200 677 dbSNP
rs1180330743 690 dbSNP
rs891918311 697 dbSNP
rs1250680632 701 dbSNP
rs1192423392 703 dbSNP
rs1466909455 714 dbSNP
rs998276506 718 dbSNP
rs979674614 728 dbSNP
rs1424531302 729 dbSNP
rs921227295 731 dbSNP
rs932566034 738 dbSNP
rs1412768873 742 dbSNP
rs1161599120 743 dbSNP
rs1241126969 747 dbSNP
rs1317411515 758 dbSNP
rs1050985435 760 dbSNP
rs912248696 762 dbSNP
rs1368805932 764 dbSNP
rs143032208 776 dbSNP
rs755394048 783 dbSNP
rs1387527623 784 dbSNP
rs963346049 787 dbSNP
rs898228414 788 dbSNP
rs1157174642 792 dbSNP
rs995055246 795 dbSNP
rs1381463951 796 dbSNP
rs1172535750 797 dbSNP
rs561112537 804 dbSNP
rs781689721 814 dbSNP
rs1199167716 817 dbSNP
rs755197208 831 dbSNP
rs1002888351 832 dbSNP
rs774156900 836 dbSNP
rs1259458736 841 dbSNP
rs992618825 842 dbSNP
rs1351384644 846 dbSNP
rs1279540353 850 dbSNP
rs1343678922 851 dbSNP
rs917019488 852 dbSNP
rs1345861154 862 dbSNP
rs573087030 863 dbSNP
rs1234299665 867 dbSNP
rs1285938151 868 dbSNP
rs1353940628 875 dbSNP
rs948459620 876 dbSNP
rs1035206898 880 dbSNP
rs1384264567 881 dbSNP
rs960725016 883 dbSNP
rs1361509118 884 dbSNP
rs1009506628 889 dbSNP
rs1021035958 890 dbSNP
rs968531850 895 dbSNP
rs979509871 896 dbSNP
rs921097342 897 dbSNP
rs540470939 910 dbSNP
rs953877928 917 dbSNP
rs1474916590 934 dbSNP
rs1370971992 935 dbSNP
rs925585148 936 dbSNP
rs987133702 937 dbSNP
rs1256489570 938 dbSNP
rs148184159 945 dbSNP
rs939690270 946 dbSNP
rs1280872035 952 dbSNP
rs56739127 953 dbSNP
rs1339051481 954 dbSNP
rs141215166 957 dbSNP
rs1229806264 958 dbSNP
rs1341557793 960 dbSNP
rs188610981 962 dbSNP
rs931059778 963 dbSNP
rs1044128474 972 dbSNP
rs1419325890 975 dbSNP
rs529757951 979 dbSNP
rs548289599 981 dbSNP
rs938182053 993 dbSNP
rs566597428 994 dbSNP
rs375607663 1006 dbSNP
rs761017005 1011 dbSNP
rs1280751344 1016 dbSNP
rs1476182221 1017 dbSNP
rs752120099 1017 dbSNP
rs770622313 1018 dbSNP
rs34681031 1021 dbSNP
rs994174534 1021 dbSNP
rs1026689570 1028 dbSNP
rs191763764 1029 dbSNP
rs992648248 1030 dbSNP
rs1283366268 1031 dbSNP
rs1272992679 1035 dbSNP
rs1009559066 1037 dbSNP
rs1357692648 1043 dbSNP
rs1285305827 1052 dbSNP
rs1020922746 1058 dbSNP
rs1442060440 1059 dbSNP
rs201097984 1067 dbSNP
rs969797682 1079 dbSNP
rs1465850327 1081 dbSNP
rs1210763399 1085 dbSNP
rs1393267662 1094 dbSNP
rs980218066 1096 dbSNP
rs755228569 1111 dbSNP
rs1462833980 1114 dbSNP
rs1289858501 1118 dbSNP
rs1450366655 1119 dbSNP
rs1176584689 1120 dbSNP
rs1468494545 1125 dbSNP
rs925647450 1126 dbSNP
rs1206797932 1128 dbSNP
rs1180555128 1135 dbSNP
rs778522498 1137 dbSNP
rs1252626108 1144 dbSNP
rs1211984251 1165 dbSNP
rs1323909312 1166 dbSNP
rs552443913 1171 dbSNP
rs1349120970 1175 dbSNP
rs182453488 1175 dbSNP
rs1310896211 1178 dbSNP
rs913516772 1181 dbSNP
rs934204121 1183 dbSNP
rs1051287309 1187 dbSNP
rs1387267741 1191 dbSNP
rs781614534 1193 dbSNP
rs1028377679 1194 dbSNP
rs75205376 1195 dbSNP
rs1398922985 1198 dbSNP
rs986612036 1209 dbSNP
rs1403530465 1222 dbSNP
rs942770405 1232 dbSNP
rs1019581127 1234 dbSNP
rs1038895190 1235 dbSNP
rs1332857989 1250 dbSNP
rs35130476 1271 dbSNP
rs1400405974 1280 dbSNP
rs1445352610 1282 dbSNP
rs961276499 1283 dbSNP
rs886056201 1284 dbSNP
rs1247694032 1292 dbSNP
rs1384515728 1303 dbSNP
rs1215509801 1315 dbSNP
rs972611138 1316 dbSNP
rs1283972444 1318 dbSNP
rs187148085 1319 dbSNP
rs1288804759 1320 dbSNP
rs557296814 1321 dbSNP
rs1047044138 1323 dbSNP
rs919604492 1325 dbSNP
rs1220647177 1329 dbSNP
rs930965862 1340 dbSNP
rs1014102420 1342 dbSNP
rs1288138902 1343 dbSNP
rs569173408 1355 dbSNP
rs1346675541 1356 dbSNP
rs1298764444 1360 dbSNP
rs1433972227 1361 dbSNP
rs1394604375 1364 dbSNP
rs1171808155 1365 dbSNP
rs1024094440 1367 dbSNP
rs1426113339 1371 dbSNP
rs927046080 1377 dbSNP
rs536283006 1378 dbSNP
rs554623286 1381 dbSNP
rs1056552070 1382 dbSNP
rs1001365391 1385 dbSNP
rs577607144 1388 dbSNP
rs1211614603 1389 dbSNP
rs1312469703 1390 dbSNP
rs775616271 1392 dbSNP
rs1212397994 1393 dbSNP
rs1188078441 1405 dbSNP
rs945636451 1407 dbSNP
rs1278580648 1410 dbSNP
rs1414132520 1412 dbSNP
rs573040186 1417 dbSNP
rs957132619 1423 dbSNP
rs1424193951 1424 dbSNP
rs903863806 1434 dbSNP
rs1000858616 1438 dbSNP
rs1170053866 1447 dbSNP
rs1028848103 1452 dbSNP
rs1426299418 1453 dbSNP
rs889874655 1465 dbSNP
rs1008097512 1466 dbSNP
rs1328651198 1476 dbSNP
rs1184049787 1484 dbSNP
rs1483308508 1487 dbSNP
rs1019466457 1489 dbSNP
rs1250217252 1491 dbSNP
rs540386411 1505 dbSNP
rs994099432 1513 dbSNP
rs1202061915 1521 dbSNP
rs1319519850 1523 dbSNP
rs1403991953 1529 dbSNP
rs558729815 1531 dbSNP
rs1333029050 1532 dbSNP
rs886056202 1534 dbSNP
rs1353263772 1539 dbSNP
rs1339085334 1541 dbSNP
rs1314772436 1542 dbSNP
rs1396497639 1542 dbSNP
rs373349980 1548 dbSNP
rs577438199 1550 dbSNP
rs979791402 1551 dbSNP
rs1464303758 1552 dbSNP
rs1279410096 1562 dbSNP
rs1317817248 1563 dbSNP
rs987018291 1564 dbSNP
rs886056203 1565 dbSNP
rs886056204 1567 dbSNP
rs1367017007 1569 dbSNP
rs1038519036 1575 dbSNP
rs1200105237 1582 dbSNP
rs1254258089 1585 dbSNP
rs1424881418 1586 dbSNP
rs761967628 1587 dbSNP
rs920033081 1594 dbSNP
rs1174965735 1596 dbSNP
rs1458855835 1597 dbSNP
rs1195548440 1601 dbSNP
rs930046858 1603 dbSNP
rs1212602028 1605 dbSNP
rs1047524376 1606 dbSNP
rs1266942528 1611 dbSNP
rs1477452563 1611 dbSNP
rs1245496730 1614 dbSNP
rs1316241391 1616 dbSNP
rs1306470290 1619 dbSNP
rs1444642604 1626 dbSNP
rs992499992 1627 dbSNP
rs546550285 1628 dbSNP
rs1440382598 1634 dbSNP
rs1389087267 1641 dbSNP
rs945516902 1644 dbSNP
rs1042646135 1650 dbSNP
rs925538051 1651 dbSNP
rs72877535 1653 dbSNP
rs1032818772 1665 dbSNP
rs1275228775 1667 dbSNP
rs1399549421 1698 dbSNP
rs1441001370 1709 dbSNP
rs957369051 1721 dbSNP
rs137932203 1725 dbSNP
rs1466844901 1730 dbSNP
rs1269252804 1732 dbSNP
rs889750490 1735 dbSNP
rs1210212552 1738 dbSNP
rs1008318388 1742 dbSNP
rs1485537223 1743 dbSNP
rs1258907248 1751 dbSNP
rs1041122539 1756 dbSNP
rs897020694 1757 dbSNP
rs1310049587 1766 dbSNP
rs993984481 1768 dbSNP
rs955059910 1772 dbSNP
rs1387721791 1774 dbSNP
rs1027357084 1777 dbSNP
rs1296918701 1778 dbSNP
rs1422010059 1785 dbSNP
rs10460565 1787 dbSNP
rs1360668436 1790 dbSNP
rs1172442892 1794 dbSNP
rs1476877082 1795 dbSNP
rs952653548 1797 dbSNP
rs1001826209 1800 dbSNP
rs1378992204 1813 dbSNP
rs1199062746 1818 dbSNP
rs1427708479 1823 dbSNP
rs1260716398 1829 dbSNP
rs34913248 1829 dbSNP
rs1034024075 1830 dbSNP
rs191141239 1839 dbSNP
rs1398679873 1840 dbSNP
rs1286915543 1845 dbSNP
rs1303977948 1858 dbSNP
rs986462027 1860 dbSNP
rs1342884827 1861 dbSNP
rs866628243 1862 dbSNP
rs143006071 1873 dbSNP
rs886056205 1874 dbSNP
rs1234182436 1878 dbSNP
rs1326229499 1882 dbSNP
rs560282307 1882 dbSNP
rs527393080 1884 dbSNP
rs992547442 1886 dbSNP
rs912968482 1888 dbSNP
rs966871910 1894 dbSNP
rs1311812572 1896 dbSNP
rs978279892 1906 dbSNP
rs1356087306 1911 dbSNP
rs1218607015 1913 dbSNP
rs1286454805 1914 dbSNP
rs925558881 1916 dbSNP
rs567016276 1917 dbSNP
rs1335928456 1918 dbSNP
rs1195568058 1920 dbSNP
rs1478139791 1920 dbSNP
rs1256731251 1921 dbSNP
rs1185237933 1922 dbSNP
rs1050392536 1926 dbSNP
rs1280764077 1927 dbSNP
rs1433287060 1935 dbSNP
rs911244917 1943 dbSNP
rs183689971 1944 dbSNP
rs1256638838 1946 dbSNP
rs1220839939 1953 dbSNP
rs920081922 1957 dbSNP
rs771587917 1962 dbSNP
rs982794938 1964 dbSNP
rs1341771827 1965 dbSNP
rs1334210713 1973 dbSNP
rs1159688684 1974 dbSNP
rs1360302226 1976 dbSNP
rs1397657597 1977 dbSNP
rs897239903 1982 dbSNP
rs1191580250 1988 dbSNP
rs1416842051 1995 dbSNP
rs994033804 1997 dbSNP
rs559684247 1999 dbSNP
rs1368891154 2002 dbSNP
rs527727589 2007 dbSNP
rs949423795 2009 dbSNP
rs1045025247 2010 dbSNP
rs1457533149 2011 dbSNP
rs1299279679 2012 dbSNP
rs905801905 2016 dbSNP
rs1319073964 2017 dbSNP
rs775228813 2017 dbSNP
rs888236595 2042 dbSNP
rs1379469667 2043 dbSNP
rs1001475409 2045 dbSNP
rs1034654070 2051 dbSNP
rs1332982666 2060 dbSNP
rs1054701286 2062 dbSNP
rs895517319 2063 dbSNP
rs1321307319 2064 dbSNP
rs1407081570 2066 dbSNP
rs1352760234 2067 dbSNP
rs1013859036 2076 dbSNP
rs773341932 2079 dbSNP
rs1157873036 2084 dbSNP
rs1439170692 2085 dbSNP
rs1378510423 2090 dbSNP
rs1020031916 2098 dbSNP
rs1458366863 2100 dbSNP
rs763024279 2103 dbSNP
rs1219805435 2104 dbSNP
rs967095092 2107 dbSNP
rs1286645160 2116 dbSNP
rs978885205 2117 dbSNP
rs1032515057 2118 dbSNP
rs892938678 2123 dbSNP
rs1010478194 2124 dbSNP
rs1440939623 2132 dbSNP
rs766651076 2134 dbSNP
rs1178870226 2135 dbSNP
rs200195574 2142 dbSNP
rs751834841 2142 dbSNP
rs759936372 2143 dbSNP
rs1438248230 2147 dbSNP
rs2564097 2148 dbSNP
rs911457882 2150 dbSNP
rs1317596296 2159 dbSNP
rs886056206 2160 dbSNP
rs964662764 2164 dbSNP
rs976739989 2167 dbSNP
rs1292233430 2168 dbSNP
rs886056207 2169 dbSNP
rs1424738238 2172 dbSNP
rs1189626503 2174 dbSNP
rs1479226943 2175 dbSNP
rs1247602346 2177 dbSNP
rs1402559308 2182 dbSNP
rs1216579473 2189 dbSNP
rs1487574471 2201 dbSNP
rs1287626883 2206 dbSNP
rs918555950 2209 dbSNP
rs930077771 2211 dbSNP
rs1276076896 2216 dbSNP
rs1220556525 2217 dbSNP
rs1368067581 2220 dbSNP
rs1277310644 2222 dbSNP
rs1193337459 2223 dbSNP
rs1342277796 2224 dbSNP
rs1048932355 2230 dbSNP
rs1420387425 2232 dbSNP
rs1358607905 2235 dbSNP
rs146108177 2237 dbSNP
rs541833364 2243 dbSNP
rs549792777 2247 dbSNP
rs937161211 2248 dbSNP
rs1426357989 2257 dbSNP
rs1193386347 2259 dbSNP
rs568373788 2264 dbSNP
rs1265995971 2273 dbSNP
rs1194949516 2274 dbSNP
rs895737249 2278 dbSNP
rs1235191516 2292 dbSNP
rs886056208 2297 dbSNP
rs1458736087 2301 dbSNP
rs1019917235 2302 dbSNP
rs1198670744 2306 dbSNP
rs902818103 2311 dbSNP
rs1378593981 2312 dbSNP
rs1395335106 2312 dbSNP
rs1301130899 2316 dbSNP
rs1450540267 2336 dbSNP
rs1407100450 2342 dbSNP
rs918023178 2343 dbSNP
rs1426183491 2347 dbSNP
rs949456015 2347 dbSNP
rs1172041561 2349 dbSNP
rs139999174 2357 dbSNP
rs1033146733 2369 dbSNP
rs1183094089 2372 dbSNP
rs1483256384 2374 dbSNP
rs1237190024 2383 dbSNP
rs1196321726 2387 dbSNP
rs1458943577 2387 dbSNP
rs1474115661 2391 dbSNP
rs1244020138 2394 dbSNP
rs1319845470 2400 dbSNP
rs937266082 2407 dbSNP
rs1230117153 2412 dbSNP
rs1383535896 2414 dbSNP
rs1414997039 2415 dbSNP
rs1054414874 2422 dbSNP
rs958254103 2423 dbSNP
rs1163336437 2426 dbSNP
rs1426354142 2427 dbSNP
rs1466256364 2436 dbSNP
rs1167440626 2439 dbSNP
rs986028472 2441 dbSNP
rs554551890 2448 dbSNP
rs1018570843 2457 dbSNP
rs1176447528 2458 dbSNP
rs890893726 2459 dbSNP
rs755619634 2460 dbSNP
rs1303580691 2462 dbSNP
rs1007956793 2464 dbSNP
rs1379626085 2467 dbSNP
rs1487351458 2478 dbSNP
rs965625666 2480 dbSNP
rs1222169897 2484 dbSNP
rs566579383 2486 dbSNP
rs1360290755 2488 dbSNP
rs534048628 2489 dbSNP
rs777198802 2496 dbSNP
rs559071637 2506 dbSNP
rs577347341 2507 dbSNP
rs1027275309 2511 dbSNP
rs1386565704 2514 dbSNP
rs1388973001 2517 dbSNP
rs879331953 2520 dbSNP
rs929936613 2526 dbSNP
rs1425821952 2529 dbSNP
rs577351249 2535 dbSNP
rs984253168 2544 dbSNP
rs1305199093 2547 dbSNP
rs909941493 2549 dbSNP
rs544817238 2551 dbSNP
rs188594037 2554 dbSNP
rs1237658310 2558 dbSNP
rs1483143405 2560 dbSNP
rs1431263083 2566 dbSNP
rs1186231235 2567 dbSNP
rs1055547091 2568 dbSNP
rs1269146630 2570 dbSNP
rs1191752893 2571 dbSNP
rs1025067811 2577 dbSNP
rs1266028273 2579 dbSNP
rs895620341 2582 dbSNP
rs1214525639 2593 dbSNP
rs1355875428 2599 dbSNP
rs1261559563 2606 dbSNP
rs1478431009 2609 dbSNP
rs1329761870 2610 dbSNP
rs1303821529 2615 dbSNP
rs1170129333 2625 dbSNP
rs1340432287 2628 dbSNP
rs970790545 2630 dbSNP
rs1417473373 2632 dbSNP
rs1385005451 2634 dbSNP
rs1171665414 2636 dbSNP
rs1464215449 2637 dbSNP
rs1379194235 2639 dbSNP
rs980791319 2642 dbSNP
rs886056209 2643 dbSNP
rs949974855 2656 dbSNP
rs1260958888 2657 dbSNP
rs753403408 2658 dbSNP
rs1195700247 2662 dbSNP
rs1041594098 2664 dbSNP
rs902862469 2667 dbSNP
rs1262487100 2672 dbSNP
rs1200129999 2683 dbSNP
rs1447076776 2685 dbSNP
rs1343131093 2686 dbSNP
rs1258196103 2689 dbSNP
rs1224521441 2694 dbSNP
rs1310843607 2695 dbSNP
rs149843342 2696 dbSNP
rs914525485 2702 dbSNP
rs1054250988 2709 dbSNP
rs1400552599 2710 dbSNP
rs1276897412 2712 dbSNP
rs1402347560 2714 dbSNP
rs1277412815 2723 dbSNP
rs1359299367 2724 dbSNP
rs1220409334 2725 dbSNP
rs541807278 2726 dbSNP
rs1278957163 2733 dbSNP
rs1393997724 2734 dbSNP
rs1311222313 2735 dbSNP
rs1176635226 2745 dbSNP
rs888853893 2750 dbSNP
rs1209259611 2753 dbSNP
rs1288581806 2764 dbSNP
rs1007275792 2769 dbSNP
rs1041591143 2774 dbSNP
rs912360247 2789 dbSNP
rs1193577134 2791 dbSNP
rs6738881 2792 dbSNP
rs1186914329 2793 dbSNP
rs965512265 2796 dbSNP
rs1440713136 2801 dbSNP
rs1245203611 2803 dbSNP
rs998449965 2806 dbSNP
rs1039489851 2819 dbSNP
rs1221047101 2821 dbSNP
rs1256537835 2821 dbSNP
rs1340678270 2827 dbSNP
rs1479060811 2832 dbSNP
rs776462497 2836 dbSNP
rs1283157528 2840 dbSNP
rs1191820716 2850 dbSNP
rs899575855 2858 dbSNP
rs995204368 2869 dbSNP
rs1048520331 2872 dbSNP
rs1025886836 2880 dbSNP
rs887372492 2883 dbSNP
rs1433079929 2884 dbSNP
rs951439872 2885 dbSNP
rs1004384095 2889 dbSNP
rs1387116743 2895 dbSNP
rs984527857 2898 dbSNP
rs910003408 2900 dbSNP
rs959052638 2902 dbSNP
rs1236805048 2904 dbSNP
rs1160623125 2906 dbSNP
rs1362224052 2913 dbSNP
rs761549821 2914 dbSNP
rs1438697386 2918 dbSNP
rs1289801954 2922 dbSNP
rs527355187 2928 dbSNP
rs1297534099 2937 dbSNP
rs970905680 2938 dbSNP
rs1361031686 2942 dbSNP
rs1315095400 2947 dbSNP
rs917099597 2949 dbSNP
rs1438042095 2951 dbSNP
rs545930038 2955 dbSNP
rs1374178843 2958 dbSNP
rs1310920704 2960 dbSNP
rs949859140 2961 dbSNP
rs1366535765 2962 dbSNP
rs1349048180 2966 dbSNP
rs1033793283 2969 dbSNP
rs958350556 2977 dbSNP
rs1164289886 2981 dbSNP
rs1231636353 2988 dbSNP
rs886056210 2988 dbSNP
rs1378717495 2990 dbSNP
rs1041646471 2997 dbSNP
rs989510464 3004 dbSNP
rs193264152 3011 dbSNP
rs144691386 3013 dbSNP
rs977301499 3021 dbSNP
rs1197418487 3024 dbSNP
rs765512018 3031 dbSNP
rs1216283471 3034 dbSNP
rs886056211 3039 dbSNP
rs1215274886 3040 dbSNP
rs886056212 3041 dbSNP
rs912474961 3041 dbSNP
rs943892127 3046 dbSNP
rs1223945070 3048 dbSNP
rs1246216348 3051 dbSNP
rs888747262 3052 dbSNP
rs549996457 3055 dbSNP
rs1406768729 3060 dbSNP
rs1180780484 3064 dbSNP
rs921049023 3065 dbSNP
rs1040115837 3073 dbSNP
rs185716161 3085 dbSNP
rs1297447604 3086 dbSNP
rs1399487295 3088 dbSNP
rs190238579 3094 dbSNP
rs1358661644 3100 dbSNP
rs148515938 3107 dbSNP
rs1401469147 3110 dbSNP
rs998338780 3111 dbSNP
rs1171169252 3113 dbSNP
rs1157752222 3117 dbSNP
rs1481588042 3120 dbSNP
rs1405789112 3121 dbSNP
rs745626475 3127 dbSNP
rs1487034601 3134 dbSNP
rs1243322402 3137 dbSNP
rs566542969 3138 dbSNP
rs1311248385 3145 dbSNP
rs772049365 3156 dbSNP
rs951711890 3158 dbSNP
rs1005769834 3161 dbSNP
rs1323913381 3170 dbSNP
rs1277527429 3183 dbSNP
rs1017353076 3187 dbSNP
rs1002404807 3200 dbSNP
rs780132052 3217 dbSNP
rs533963774 3218 dbSNP
rs1278142700 3219 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacgugucuguugUCUUCCUu 5'
                       ||||||| 
Target 5' --------ucuggAGAAGGAa 3'
 		1 - 13
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5194.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177622. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_12 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000295030.5 | 3UTR | UCUGGAGAAGGAAUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1