miRTarBase - #MIRT506321


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pre-miRNA Information
pre-miRNA hsa-mir-4778   
Genomic Coordinates chr2: 66358249 - 66358328
Description Homo sapiens miR-4778 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4778-3p
Sequence 51| UCUUCUUCCUUUGCAGAGUUGA |72
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs936001904 2 dbSNP
rs925922703 3 dbSNP
rs184768286 8 dbSNP
rs1249073833 10 dbSNP
rs977504360 13 dbSNP
rs192300002 18 dbSNP
Putative Targets

Gene Information
Gene Symbol OTUD4   
Synonyms DUBA6, HIN1, HSHIN1
Description OTU deubiquitinase 4
Transcript NM_001102653   
Other Transcripts NM_017493   
Expression
Putative miRNA Targets on OTUD4
3'UTR of OTUD4
(miRNA target sites are highlighted)		 
>OTUD4|NM_001102653|3'UTR
   1 TGGTTGTTGCCGAAGTATTTTCTAACAGAAACTCTTAGGTGGAATGTTTCTGAAGGCTTTAAAAAAAATACAATAAAGTA
  81 AAAACCGCAGTTGGAACTCTTTCCTCTCCCCAGCCCCCCTTACCTTCACTCCCATACTGGACAAGACATTTTGGACATGA
 161 GTTCAAGGGGGCAGGTTAATTCCTGGCATTGCCAGTTTTCTTCATTCAGAATCTGTTTGTTGATCAAGTGACTGTCCCCG
 241 TAAAAAGTAGAAGATAAGTTTGTTAAAGTATTTTTTATAAACAGCTTAATATAAAACATTATAGATTTAGTGTTTGGCTT
 321 TTTTCCTTATAAGTTTATAAGTTTGATTTCAGATGTTGGAAATGTGTGCTTTATAGTGTTTACTAAAGTGACAAGAAAAT
 401 ATACCATTTGACACACTATAGATTCCAAACATAACGTTGCACCAAATAGAAATGTATATTTTATTATGCAATGCCTTAGT
 481 CATAAACTGGGCTCAAACAATTCTCAGCCTAAAACACTGTTGTCTTTTAAAATGCTTCCAACCCAAAGGCCTTTCATCTC
 561 AATATCTGTCAAACTTGAATAATGTCTTCTCTTTAATATTCACATAAGGCAGCCTATTAACTGTGTCTTAGCAATGTTGT
 641 ATATAGTTCTTTTAATATTCATAAGGTATATTTTTGAATTTTGGTATTTGTTGAGATTGCATAGAAGAATAGTAGGAAAT
 721 CCAATGAAATGGCTGTTTCCACCAAGAATTCTTAGCACTGGTGTAAATATCATGGTGCCTACTCGAAAGAAATGTAGATG
 801 CTATGCATTTTGAAAATAATCTGCATCAGTTAGAACTGCAGAAGTTTTTTTAATGCCACTTTAACACTAATGCACTGACA
 881 GATTCTAAATATTTTGTGAGAAGAAATGTTAAAAATTTTTAGCTTGACAGGTTTCTAGAGTTGTTTTCTTCCTCCCCCCC
 961 CCCCCCGCACCATTGGTTGTGTATCACTTTCACTTTACACTTGCATGTTCTACTTGTCAGGGCTGGAACTATTGTATAGA
1041 AGATAATATGATTGTGACTTCTAGTTCTTTTCTAGAGGATGCTGCTAGAAAATGGTTTTGCTTTGTATTTTATAGCTTGT
1121 TACCCTTAGGTAGGTAACATCTTACATTCTGTTTTCTTCCAGTCTTTGCAGTATTCACTAGAGGTTCCCTTTGCATGTTG
1201 CACTCTGTTCTCATTTGGAGATTGAACTCTGAATTAACACAGTATTCATTCATCTGTGTTATTTTGTAAAAATAACTGTA
1281 GCTTATATTCTTTATTTGTGCATACCAATGTGAAAATCCACTCTTTTATTATGTTGAGATTATCTTCTGATCAGGAAGTT
1361 TGAGTGCTATGCAAATAACATAGTAGTAATTTCTCTTTGCATGCCATGTGTAATATACCTAGCCAAAACCAGATGCGGTG
1441 ACTTTCTTTTTTTGTAAAGCAAATTACTTAAGAAAATACAATTCACTTGAATTTGACAAACTGAAACAGATGGGTTTTCT
1521 GGGTTCTCTGATAACCTATGGGAATGTTTGGATGCCAGTTGGGCTAGTGAATCGCCACTGTACTGTAATAATGGTTATTT
1601 ACCTCTGTGCTGTTTTAATTACCTAACGTCTGTGTAACTGCTGATTTGAGTAGTGATTAGCATTTAGATAATGTAACAGG
1681 ATTTTAGAGAGCACTTTGAAAGATAACATTTTATTATGATGGTGCTAGGTAAAAAATTGTAAAGACTGGGATGGTTGTGT
1761 GGAAAACTTTTCTTGAGAGAACCTATTGAAAGGAATTTGTTGTCACCTTCTTAACTAGAATAGTTGTTGAAGGTACCGCT
1841 TAAGCCATTTTTTTCTTAACATCGGTGGCTCAGTTAAGGAATGAGAAGATAGAGGGTCCTCCACTTTCAGCTCATGCTTT
1921 TTTATGTAGGACTAGCTTACCTGATTTTAATGAAAATCACATTTTGATACAAACACCAGATTTGAAAGTTCAATGTGTTT
2001 GATCTCAGGAGTCCAAAATAAGTTGTTGCTTCTAGTGTCCTGCATTTTATTGACTGGGGTTTGATCTCAGCTTCTGAAAA
2081 TGTTTAAAAATTGGAAGGAAATACTACTCATATCTTCATTGTCACTTTGTCTTACCTCAATTGAGTAACAGAATATAGCT
2161 CCTGAAGGAAACACTGATTTGCTTTCTGTTTCCCATATCTCACCTCTAGGATATGATGGAAGAAGTGCTTGAAAGAGAAT
2241 TTTAGCAGATGGTACTTTTCTCAGTGACCTCTGGAATAAAAGAACTGACTTTTGATAGTTTTAAAATTAATCTTTGCATG
2321 AAGGTTGGTTTCGCTTTTTTTCCTTTAAGTTTGTTTTTAAATGTATTAGTCCAGGGGATTTTGCCTTATGCTGAGGTCAA
2401 ACTAAGGATAAGCAAGCTTTTGTCCTTCATTTTAACTGTTATGTCATACTGTTATGTTGACATATTTCTTTATAAGAGAA
2481 TAGAGGCAAAAGTATAGAACTGAGGATCATTTGTATTTTTGAGTTGGAAATTATGAAACTTCACCATATTATGATCATAC
2561 ATATTTTGAAGAACAGACTGACCAAAGCTCACCTGTTTTTTGTGTTAGGTGCTTTGGCTGAACTTGATTCCAGCCCCCTT
2641 TTCCCTTTGGTGTTGTGTATGTCTCTTCATTTCCTCTCAAATCTTCAACTCTTGCCCCATGTCTCCTTGGCAGCAGGATG
2721 CTGGCATCTGTGTAGTCCTCATACTGTTTACTGATAACCCACAAATTCATTTTCATGGCAGACCTAAGCTCAGACCCTGC
2801 CTTGTCCTGGCAAGCATAGGTTTTCCCAGACCACAATGCTGATATATCTTATTTAATGCAGACTGTATTCTTGCAGCGTG
2881 TTGTTTCCTTTGTGACTCAAGGTTGAATTAAAATGCCTGTGAACTGCAAACTTGCTTATGATTGACTTGGTGCAATAAAG
2961 TTCCTTTCTAACCATTTCTGGTTTAGAAAACATTCAGCCATCCTAGAAACTAGCAATATTTATTTTTGCCTCTTTCGTTT
3041 TACCTTCATTTTTAGATGAGGTAAATGTTTTGTCTTTTACTTAAGGGTACTAAGCAAGGTCCACTCTAGTGTAGCTGAAG
3121 AGAATGCATATTTGGCTACACTATTTCTGTTTACTGTATTTTGCTTCCTACTTTATGTCTAAATGCTATTGTTTGTTTAA
3201 AATCCTAATAATGTCTCATTTCCAATATGTTATTTTCAGATAACTAAGGTTTTGCTACTAATGTCAGCCATTTACTCTCC
3281 CACTAATTGGGATTATTTTTTAAAAGAGGTCTTTCTCCCCGAAATACAAGTTTTAGAAAATCTTAGAAGAGGGGTGGGTG
3361 CATGTCTTAATGCTGGGAAGCGGCAACTTTGGGGTTGAACTTACTTGAATGGATTAAAAATTGCATTGTGTTACAGAGCT
3441 AGAAAATTTTATGTATGAAAAACGATAATAGCCTTACACTGAGTACAAATAATACTTTAAGAGCATGTGAAGATGTGATC
3521 ATTTGTGATGTTACTTGTAAAAAAAAGTATATATACATATCTTTTGAAGTGTTAAAAGGAAACTAGTACTTTATATTCTT
3601 TATCATATCACTTTTTGTAAGTGTTGAATATATTCCTGTTTATTTTTCTATGTTCTGTTTTGTAGCCTTAAGAAGTGTTT
3681 CAAACATATCTGAATGTATAAAATAAGAGTAAATGCCCTACATGGTGTGATGCTGCATTATATATAAAACTGTGTGCATA
3761 TATTAAATTTTGTCTCTTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUUGAGA--C---GUUUCCUUCUUCu 5'
            | ||||  |   ::| |||||||| 
Target 5' tcACCTCTAGGATATGATGGAAGAAGt 3'
 2200 - 2226 154.00 -15.10
2 
miRNA  3' aguUGAGACGUUUCCUUCUUcu 5'
             |:|:||::|  ||||||  
Target 5' aatATTTTGTGA--GAAGAAat 3'
 888 - 907 139.00 -8.50
3 
miRNA  3' aguugaGACGUUUCCUUCUUcu 5'
                :|||| | ||||||  
Target 5' ttgagaTTGCATA-GAAGAAta 3'
 691 - 711 135.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30112314 12 COSMIC
COSN31585644 28 COSMIC
COSN30177950 34 COSMIC
COSN31587071 42 COSMIC
COSN31610205 57 COSMIC
COSN30494949 58 COSMIC
COSN26987686 60 COSMIC
COSN18728607 61 COSMIC
COSN30516717 61 COSMIC
COSN31565293 81 COSMIC
COSN30682128 87 COSMIC
COSN30540472 99 COSMIC
COSN31491554 112 COSMIC
COSN30462409 115 COSMIC
COSN30515696 131 COSMIC
COSN32062772 188 COSMIC
COSN31520656 304 COSMIC
COSN23284573 310 COSMIC
COSN31549906 364 COSMIC
COSN17452446 415 COSMIC
COSN7741414 425 COSMIC
COSN26635362 443 COSMIC
COSN31523019 462 COSMIC
COSN20202918 555 COSMIC
COSN9217255 566 COSMIC
COSN30174540 649 COSMIC
COSN19062226 788 COSMIC
COSN28201100 801 COSMIC
COSN30540461 821 COSMIC
COSN31519833 913 COSMIC
COSN20100587 941 COSMIC
COSN30175342 952 COSMIC
COSN14780017 976 COSMIC
COSN26415842 1152 COSMIC
COSN31585856 1219 COSMIC
COSN6804741 1233 COSMIC
COSN23070352 1234 COSMIC
COSN5556466 1294 COSMIC
COSN26555634 1405 COSMIC
COSN15660344 1454 COSMIC
COSN31587944 1487 COSMIC
COSN6577972 1679 COSMIC
COSN29195911 1744 COSMIC
COSN31528645 1829 COSMIC
COSN31549041 2248 COSMIC
COSN24685647 2250 COSMIC
COSN23987366 2262 COSMIC
COSN31519554 2305 COSMIC
COSN19661172 2343 COSMIC
COSN7741413 2343 COSMIC
COSN31571109 2650 COSMIC
COSN22605466 2680 COSMIC
COSN30539658 2794 COSMIC
COSN31488580 2829 COSMIC
COSN31823794 2965 COSMIC
COSN31602581 2966 COSMIC
COSN31609442 3006 COSMIC
COSN31531239 3040 COSMIC
COSN7776801 3081 COSMIC
COSN31488274 3120 COSMIC
COSN31519835 3122 COSMIC
COSN8490181 3215 COSMIC
COSN31526763 3259 COSMIC
COSN31482219 3279 COSMIC
COSN25267715 3310 COSMIC
COSN25264450 3314 COSMIC
COSN31606845 3321 COSMIC
COSN31606693 3338 COSMIC
COSN31514814 3381 COSMIC
COSN28670582 3465 COSMIC
COSN30173069 3530 COSMIC
COSN26562440 3583 COSMIC
COSN26566000 3609 COSMIC
COSN22705989 3658 COSMIC
COSN31484671 3733 COSMIC
rs11545157 3465 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773259194 2 dbSNP
rs759530661 3 dbSNP
rs1424190291 6 dbSNP
rs369947596 11 dbSNP
rs772387217 12 dbSNP
rs765429298 13 dbSNP
rs1455328735 18 dbSNP
rs762155627 22 dbSNP
rs1238555405 23 dbSNP
rs1190235039 24 dbSNP
rs1440997395 29 dbSNP
rs776942546 30 dbSNP
rs1209792349 31 dbSNP
rs1331455321 33 dbSNP
rs1410857687 35 dbSNP
rs199630537 36 dbSNP
rs748148266 37 dbSNP
rs377758498 38 dbSNP
rs764566822 38 dbSNP
rs370709729 39 dbSNP
rs1312529004 43 dbSNP
rs1320265648 44 dbSNP
rs1285824479 45 dbSNP
rs1413417499 46 dbSNP
rs1163046587 50 dbSNP
rs1156962915 59 dbSNP
rs549573301 60 dbSNP
rs1455804546 61 dbSNP
rs921943754 63 dbSNP
rs1206216263 66 dbSNP
rs974831558 66 dbSNP
rs1483406976 68 dbSNP
rs529802439 69 dbSNP
rs911695884 69 dbSNP
rs966529543 69 dbSNP
rs1420616409 72 dbSNP
rs1381479265 75 dbSNP
rs55906636 78 dbSNP
rs368312871 83 dbSNP
rs758764542 86 dbSNP
rs978322806 87 dbSNP
rs1456784975 89 dbSNP
rs560869943 90 dbSNP
rs966591875 91 dbSNP
rs1360949268 93 dbSNP
rs1022154013 98 dbSNP
rs774545734 102 dbSNP
rs1302449585 109 dbSNP
rs1377472230 110 dbSNP
rs1412008693 115 dbSNP
rs1010791811 118 dbSNP
rs540954612 119 dbSNP
rs1227080375 120 dbSNP
rs182079017 120 dbSNP
rs1264511773 121 dbSNP
rs959007023 124 dbSNP
rs1033307083 136 dbSNP
rs1235339860 138 dbSNP
rs564935423 139 dbSNP
rs1182554447 141 dbSNP
rs1250799395 142 dbSNP
rs1003258280 143 dbSNP
rs1427400933 144 dbSNP
rs544676319 147 dbSNP
rs1415067641 157 dbSNP
rs1355689375 159 dbSNP
rs1357583371 161 dbSNP
rs1432021478 170 dbSNP
rs1286675992 172 dbSNP
rs1350231933 175 dbSNP
rs576090742 179 dbSNP
rs1408580345 182 dbSNP
rs1277079901 185 dbSNP
rs1233238482 193 dbSNP
rs113568028 194 dbSNP
rs906265889 203 dbSNP
rs544046500 204 dbSNP
rs1343949882 209 dbSNP
rs1437445579 216 dbSNP
rs36227000 222 dbSNP
rs1273704319 228 dbSNP
rs1005444731 234 dbSNP
rs555181414 240 dbSNP
rs1384008888 241 dbSNP
rs73851363 248 dbSNP
rs1478403527 259 dbSNP
rs1173598602 262 dbSNP
rs1423146960 265 dbSNP
rs1451613867 266 dbSNP
rs1169433515 270 dbSNP
rs1433453822 270 dbSNP
rs566236556 271 dbSNP
rs930902512 271 dbSNP
rs1326129855 272 dbSNP
rs576600664 277 dbSNP
rs1173596057 290 dbSNP
rs1039454303 292 dbSNP
rs1478112398 303 dbSNP
rs1366708987 307 dbSNP
rs1228730892 310 dbSNP
rs944759585 310 dbSNP
rs1241166436 319 dbSNP
rs911962220 328 dbSNP
rs1451032757 329 dbSNP
rs1489001200 332 dbSNP
rs1219264284 334 dbSNP
rs36227001 337 dbSNP
rs1451368093 341 dbSNP
rs554589106 345 dbSNP
rs1389722839 351 dbSNP
rs3816499 352 dbSNP
rs1448052827 356 dbSNP
rs748913790 362 dbSNP
rs36227002 363 dbSNP
rs201150030 366 dbSNP
rs1405340467 373 dbSNP
rs1322107512 375 dbSNP
rs1390241739 381 dbSNP
rs1435127303 385 dbSNP
rs373480511 385 dbSNP
rs554475469 385 dbSNP
rs1219592625 388 dbSNP
rs915094504 392 dbSNP
rs1284626006 395 dbSNP
rs1355339744 396 dbSNP
rs1268659743 403 dbSNP
rs989318907 405 dbSNP
rs1220505648 406 dbSNP
rs1209368196 412 dbSNP
rs1466320467 412 dbSNP
rs1341179306 414 dbSNP
rs185244473 418 dbSNP
rs144795214 421 dbSNP
rs1238449289 426 dbSNP
rs1033634492 428 dbSNP
rs1161997994 434 dbSNP
rs549833292 435 dbSNP
rs1457313419 436 dbSNP
rs530111007 440 dbSNP
rs1201847781 441 dbSNP
rs1385789951 454 dbSNP
rs970441353 456 dbSNP
rs781416990 458 dbSNP
rs878880010 459 dbSNP
rs757603814 464 dbSNP
rs764710789 466 dbSNP
rs1334357051 472 dbSNP
rs1339680606 474 dbSNP
rs1015747967 483 dbSNP
rs1003980969 485 dbSNP
rs1165759415 485 dbSNP
rs1329853491 491 dbSNP
rs1227699319 493 dbSNP
rs1267647044 500 dbSNP
rs1348585371 515 dbSNP
rs780570691 518 dbSNP
rs1257060024 529 dbSNP
rs554021469 535 dbSNP
rs1461475808 544 dbSNP
rs1442217455 557 dbSNP
rs1186172567 562 dbSNP
rs1254411437 564 dbSNP
rs1473238098 598 dbSNP
rs1182059966 601 dbSNP
rs1409169178 607 dbSNP
rs1467087694 609 dbSNP
rs1172815131 610 dbSNP
rs1027827358 615 dbSNP
rs1412399112 616 dbSNP
rs995054454 621 dbSNP
rs1423707931 623 dbSNP
rs1186689417 627 dbSNP
rs567156801 632 dbSNP
rs547179807 634 dbSNP
rs1235435484 635 dbSNP
rs944689945 637 dbSNP
rs1210500974 640 dbSNP
rs1437050016 641 dbSNP
rs1277275391 643 dbSNP
rs890474668 644 dbSNP
rs1042841312 646 dbSNP
rs1248965568 648 dbSNP
rs779128829 651 dbSNP
rs1199040224 652 dbSNP
rs1318948640 654 dbSNP
rs1376563795 658 dbSNP
rs868699565 666 dbSNP
rs1170066573 667 dbSNP
rs1292675986 668 dbSNP
rs1428807214 674 dbSNP
rs182445387 682 dbSNP
rs1381907658 684 dbSNP
rs1392706960 686 dbSNP
rs915039150 702 dbSNP
rs1302138980 703 dbSNP
rs756417497 707 dbSNP
rs1330571442 710 dbSNP
rs1232420772 719 dbSNP
rs368967462 736 dbSNP
rs36227003 758 dbSNP
rs1442166568 761 dbSNP
rs937883409 767 dbSNP
rs1249972223 770 dbSNP
rs1333860530 774 dbSNP
rs1210937501 776 dbSNP
rs1266106964 778 dbSNP
rs759248604 784 dbSNP
rs1390346245 785 dbSNP
rs926512620 792 dbSNP
rs186594384 793 dbSNP
rs1448652967 795 dbSNP
rs1400585893 801 dbSNP
rs1168143455 807 dbSNP
rs531174940 820 dbSNP
rs1163512593 821 dbSNP
rs1458391603 823 dbSNP
rs562594148 825 dbSNP
rs752031704 833 dbSNP
rs1438730768 834 dbSNP
rs1015279755 837 dbSNP
rs982491796 838 dbSNP
rs542774005 839 dbSNP
rs952448907 843 dbSNP
rs1182346537 845 dbSNP
rs1469609827 846 dbSNP
rs1026770392 849 dbSNP
rs995002206 852 dbSNP
rs1482101253 854 dbSNP
rs1458338422 855 dbSNP
rs573765305 856 dbSNP
rs1265318083 859 dbSNP
rs777256700 861 dbSNP
rs1272812307 871 dbSNP
rs555245071 879 dbSNP
rs1464206806 881 dbSNP
rs1323544500 883 dbSNP
rs1424135158 885 dbSNP
rs1164010451 889 dbSNP
rs28488496 891 dbSNP
rs547376478 896 dbSNP
rs1161534472 906 dbSNP
rs1389439279 906 dbSNP
rs1371897376 907 dbSNP
rs1381821863 907 dbSNP
rs1430327130 907 dbSNP
rs890412959 911 dbSNP
rs568372703 917 dbSNP
rs1354189929 918 dbSNP
rs1230763838 919 dbSNP
rs945410579 921 dbSNP
rs1327835459 928 dbSNP
rs1213253402 935 dbSNP
rs1257346426 937 dbSNP
rs1377120384 939 dbSNP
rs76459724 942 dbSNP
rs1324840891 943 dbSNP
rs201466430 945 dbSNP
rs3063573 945 dbSNP
rs397706799 945 dbSNP
rs71250026 945 dbSNP
rs1351095008 947 dbSNP
rs867352823 948 dbSNP
rs1164941924 949 dbSNP
rs1182771855 949 dbSNP
rs1399971261 950 dbSNP
rs1159683589 951 dbSNP
rs28634337 952 dbSNP
rs796950169 953 dbSNP
rs1312718784 954 dbSNP
rs1361049110 954 dbSNP
rs3063572 954 dbSNP
rs1372009347 955 dbSNP
rs1412270464 955 dbSNP
rs1180223002 956 dbSNP
rs1221506184 956 dbSNP
rs1302759984 956 dbSNP
rs1440108801 957 dbSNP
rs752879237 957 dbSNP
rs893887587 958 dbSNP
rs1252185769 959 dbSNP
rs13136546 959 dbSNP
rs1175627675 960 dbSNP
rs1469700336 960 dbSNP
rs1483889266 960 dbSNP
rs1191958207 961 dbSNP
rs1434035738 961 dbSNP
rs764367711 961 dbSNP
rs1431965229 962 dbSNP
rs765345885 962 dbSNP
rs1367140993 963 dbSNP
rs1233146686 964 dbSNP
rs1300739471 964 dbSNP
rs1489620824 965 dbSNP
rs1223648817 966 dbSNP
rs1491573465 966 dbSNP
rs1169688244 967 dbSNP
rs1190016664 967 dbSNP
rs1193267466 967 dbSNP
rs1248571775 967 dbSNP
rs1326060810 967 dbSNP
rs1393441939 967 dbSNP
rs1451554136 967 dbSNP
rs1488826201 967 dbSNP
rs1491468812 967 dbSNP
rs759840979 967 dbSNP
rs769298389 967 dbSNP
rs7657990 968 dbSNP
rs1266107290 969 dbSNP
rs1277427666 969 dbSNP
rs1213077346 970 dbSNP
rs7657989 970 dbSNP
rs1251201534 971 dbSNP
rs1466459262 973 dbSNP
rs1823939 976 dbSNP
rs1474601666 981 dbSNP
rs937832342 991 dbSNP
rs1315596671 998 dbSNP
rs1461370666 1000 dbSNP
rs1162247084 1003 dbSNP
rs1288814161 1004 dbSNP
rs1002248683 1007 dbSNP
rs1317148860 1013 dbSNP
rs1324492411 1016 dbSNP
rs1449885418 1018 dbSNP
rs1284715707 1027 dbSNP
rs1354804360 1036 dbSNP
rs764748232 1038 dbSNP
rs539042802 1039 dbSNP
rs1231356419 1043 dbSNP
rs576055008 1045 dbSNP
rs754541076 1046 dbSNP
rs1331273303 1049 dbSNP
rs1046722928 1051 dbSNP
rs949335859 1058 dbSNP
rs36227324 1064 dbSNP
rs1190128539 1065 dbSNP
rs1384703745 1067 dbSNP
rs1369288961 1074 dbSNP
rs1258644635 1075 dbSNP
rs1293542261 1080 dbSNP
rs1475198341 1096 dbSNP
rs1186391202 1100 dbSNP
rs1413576989 1116 dbSNP
rs1429440775 1125 dbSNP
rs182061836 1133 dbSNP
rs1358501950 1137 dbSNP
rs1157651097 1145 dbSNP
rs1382239009 1149 dbSNP
rs772819994 1151 dbSNP
rs1420278646 1160 dbSNP
rs1334627256 1165 dbSNP
rs1374592945 1167 dbSNP
rs1412888384 1177 dbSNP
rs1290084374 1179 dbSNP
rs1352420215 1180 dbSNP
rs1239772571 1185 dbSNP
rs1394234144 1188 dbSNP
rs1279025799 1189 dbSNP
rs1348876881 1194 dbSNP
rs1173772609 1205 dbSNP
rs1202376906 1209 dbSNP
rs1435063365 1212 dbSNP
rs919658878 1216 dbSNP
rs975172465 1222 dbSNP
rs1485527950 1235 dbSNP
rs190195403 1241 dbSNP
rs1017773963 1266 dbSNP
rs1419158038 1276 dbSNP
rs1180555600 1278 dbSNP
rs1009529791 1280 dbSNP
rs954973791 1284 dbSNP
rs1172759261 1285 dbSNP
rs1021199461 1290 dbSNP
rs1432566536 1293 dbSNP
rs1009503304 1294 dbSNP
rs567418740 1308 dbSNP
rs1278548339 1310 dbSNP
rs1390732160 1319 dbSNP
rs1328333909 1321 dbSNP
rs893835387 1325 dbSNP
rs1235741172 1328 dbSNP
rs1235903857 1328 dbSNP
rs1347629383 1331 dbSNP
rs1232467289 1335 dbSNP
rs1053771373 1336 dbSNP
rs1481280037 1337 dbSNP
rs1195699949 1358 dbSNP
rs1313535095 1364 dbSNP
rs547193890 1366 dbSNP
rs1002264427 1368 dbSNP
rs533709161 1369 dbSNP
rs1193890709 1372 dbSNP
rs761828645 1372 dbSNP
rs1394028503 1378 dbSNP
rs775779894 1379 dbSNP
rs1452178922 1381 dbSNP
rs904987628 1383 dbSNP
rs1373405461 1388 dbSNP
rs1213665916 1389 dbSNP
rs1046239601 1395 dbSNP
rs1337740753 1398 dbSNP
rs949277293 1400 dbSNP
rs766446244 1401 dbSNP
rs908454360 1407 dbSNP
rs760527938 1414 dbSNP
rs372872304 1416 dbSNP
rs1374779849 1429 dbSNP
rs1300314654 1430 dbSNP
rs1308406904 1432 dbSNP
rs1227371317 1436 dbSNP
rs151074137 1437 dbSNP
rs369544316 1438 dbSNP
rs752508242 1444 dbSNP
rs1213841117 1446 dbSNP
rs1378387555 1446 dbSNP
rs1466895095 1448 dbSNP
rs919608526 1448 dbSNP
rs1262210690 1449 dbSNP
rs560731165 1450 dbSNP
rs1190957701 1460 dbSNP
rs1370052762 1466 dbSNP
rs1425859362 1472 dbSNP
rs541560852 1473 dbSNP
rs1475132775 1477 dbSNP
rs963834345 1477 dbSNP
rs1460098905 1478 dbSNP
rs1254712706 1479 dbSNP
rs531613401 1486 dbSNP
rs1202503232 1494 dbSNP
rs186463598 1499 dbSNP
rs1342839643 1503 dbSNP
rs1234410621 1504 dbSNP
rs1272029712 1510 dbSNP
rs1063614 1512 dbSNP
rs1331982961 1516 dbSNP
rs781497775 1521 dbSNP
rs1260893770 1536 dbSNP
rs987653853 1538 dbSNP
rs1315747513 1542 dbSNP
rs955068940 1548 dbSNP
rs1021148756 1551 dbSNP
rs1475523400 1559 dbSNP
rs1009786015 1562 dbSNP
rs1417275166 1563 dbSNP
rs1474233961 1573 dbSNP
rs771018266 1574 dbSNP
rs773128754 1575 dbSNP
rs1453302005 1577 dbSNP
rs1287536176 1578 dbSNP
rs958009296 1581 dbSNP
rs548992967 1589 dbSNP
rs1293163981 1592 dbSNP
rs1353041445 1603 dbSNP
rs1229632546 1610 dbSNP
rs1310530305 1627 dbSNP
rs1397756200 1628 dbSNP
rs1002665679 1639 dbSNP
rs1257585731 1641 dbSNP
rs1063615 1643 dbSNP
rs1485847513 1660 dbSNP
rs1210090700 1661 dbSNP
rs905271272 1662 dbSNP
rs1483992360 1667 dbSNP
rs1297451074 1675 dbSNP
rs1408773781 1676 dbSNP
rs1418759517 1681 dbSNP
rs1157137804 1685 dbSNP
rs1464260833 1692 dbSNP
rs1046958966 1694 dbSNP
rs1435667842 1694 dbSNP
rs36227325 1696 dbSNP
rs1444974790 1703 dbSNP
rs1298301962 1706 dbSNP
rs529752591 1707 dbSNP
rs1221736809 1713 dbSNP
rs1474938513 1714 dbSNP
rs1348328543 1715 dbSNP
rs1233377316 1718 dbSNP
rs541625760 1720 dbSNP
rs1190189187 1722 dbSNP
rs1344286706 1722 dbSNP
rs1205093922 1735 dbSNP
rs1233552003 1738 dbSNP
rs1424956849 1741 dbSNP
rs1175717230 1744 dbSNP
rs931218799 1753 dbSNP
rs572517676 1754 dbSNP
rs36227326 1758 dbSNP
rs547255286 1759 dbSNP
rs1412171707 1760 dbSNP
rs1171688600 1762 dbSNP
rs912294699 1762 dbSNP
rs761726786 1768 dbSNP
rs1198682582 1770 dbSNP
rs1371352420 1771 dbSNP
rs1355001612 1772 dbSNP
rs1301026557 1779 dbSNP
rs1341160424 1781 dbSNP
rs758958971 1782 dbSNP
rs1263225645 1785 dbSNP
rs1272136874 1796 dbSNP
rs1246886845 1799 dbSNP
rs933474299 1799 dbSNP
rs1307001005 1804 dbSNP
rs532184199 1807 dbSNP
rs1202609819 1812 dbSNP
rs1275115995 1813 dbSNP
rs545410432 1822 dbSNP
rs544198651 1826 dbSNP
rs1251558973 1836 dbSNP
rs1341065179 1836 dbSNP
rs988314192 1837 dbSNP
rs958290518 1838 dbSNP
rs1419509652 1840 dbSNP
rs1408700406 1842 dbSNP
rs1166526500 1844 dbSNP
rs1394531053 1845 dbSNP
rs1032590876 1846 dbSNP
rs1341120175 1847 dbSNP
rs1444331807 1854 dbSNP
rs1431113871 1855 dbSNP
rs1379342382 1861 dbSNP
rs1269376976 1863 dbSNP
rs1359858301 1864 dbSNP
rs1332257062 1865 dbSNP
rs1295245070 1866 dbSNP
rs980796650 1871 dbSNP
rs1287909045 1873 dbSNP
rs1448951072 1880 dbSNP
rs1461163108 1882 dbSNP
rs1217026792 1883 dbSNP
rs1241868453 1887 dbSNP
rs867706870 1888 dbSNP
rs1014101634 1890 dbSNP
rs1025046966 1890 dbSNP
rs1474560258 1896 dbSNP
rs1458804785 1898 dbSNP
rs886900446 1907 dbSNP
rs576318792 1908 dbSNP
rs1400920765 1909 dbSNP
rs556185224 1920 dbSNP
rs898409987 1921 dbSNP
rs1040049886 1924 dbSNP
rs1157182209 1925 dbSNP
rs1356193786 1928 dbSNP
rs942367512 1933 dbSNP
rs1282486139 1934 dbSNP
rs1441965403 1935 dbSNP
rs890799400 1940 dbSNP
rs36227327 1941 dbSNP
rs1284042318 1949 dbSNP
rs1487482814 1953 dbSNP
rs1213656360 1955 dbSNP
rs1450744664 1960 dbSNP
rs945803654 1970 dbSNP
rs1184856690 1976 dbSNP
rs182052033 1984 dbSNP
rs749388966 1988 dbSNP
rs1157592714 1993 dbSNP
rs1356899712 1994 dbSNP
rs1405550525 2003 dbSNP
rs1285258080 2007 dbSNP
rs1237917062 2008 dbSNP
rs553941734 2009 dbSNP
rs1374835626 2011 dbSNP
rs936880799 2027 dbSNP
rs1332319914 2035 dbSNP
rs1337565045 2037 dbSNP
rs925522406 2045 dbSNP
rs753195523 2053 dbSNP
rs981461024 2058 dbSNP
rs1329566139 2059 dbSNP
rs1325540914 2065 dbSNP
rs980501370 2066 dbSNP
rs969388986 2080 dbSNP
rs879750305 2081 dbSNP
rs1347859301 2101 dbSNP
rs143766486 2103 dbSNP
rs1422113928 2109 dbSNP
rs140187317 2110 dbSNP
rs1235909279 2112 dbSNP
rs146139564 2113 dbSNP
rs1174079615 2116 dbSNP
rs1018161610 2118 dbSNP
rs1477454654 2119 dbSNP
rs1375587581 2121 dbSNP
rs1398740221 2122 dbSNP
rs1200320223 2131 dbSNP
rs188201272 2137 dbSNP
rs890759820 2140 dbSNP
rs1051209976 2147 dbSNP
rs1443354718 2152 dbSNP
rs1261894662 2153 dbSNP
rs1304685123 2153 dbSNP
rs200317775 2158 dbSNP
rs1370665802 2161 dbSNP
rs1214337733 2164 dbSNP
rs1009892294 2174 dbSNP
rs891543726 2175 dbSNP
rs1339486498 2179 dbSNP
rs1054159333 2180 dbSNP
rs1255577890 2188 dbSNP
rs1469567986 2199 dbSNP
rs1193835734 2201 dbSNP
rs1252167433 2203 dbSNP
rs569172888 2213 dbSNP
rs936830270 2215 dbSNP
rs925457632 2217 dbSNP
rs1218440755 2226 dbSNP
rs1045298955 2231 dbSNP
rs1463244951 2237 dbSNP
rs1326770964 2240 dbSNP
rs948311563 2241 dbSNP
rs1385388714 2248 dbSNP
rs773865503 2250 dbSNP
rs549005104 2251 dbSNP
rs1234294040 2254 dbSNP
rs1327576803 2254 dbSNP
rs1804528 2262 dbSNP
rs1275787236 2264 dbSNP
rs951382166 2267 dbSNP
rs1213942202 2268 dbSNP
rs1218417940 2271 dbSNP
rs560308772 2273 dbSNP
rs748925448 2282 dbSNP
rs962513544 2285 dbSNP
rs1191367406 2289 dbSNP
rs1421609698 2303 dbSNP
rs1018526844 2311 dbSNP
rs1165934647 2314 dbSNP
rs143218464 2319 dbSNP
rs955463885 2321 dbSNP
rs1291036995 2325 dbSNP
rs1361739779 2327 dbSNP
rs1029620584 2332 dbSNP
rs1009839459 2333 dbSNP
rs1413150611 2335 dbSNP
rs78524342 2341 dbSNP
rs1404847731 2342 dbSNP
rs202186919 2343 dbSNP
rs1233437345 2344 dbSNP
rs397752909 2344 dbSNP
rs35697444 2347 dbSNP
rs36227329 2347 dbSNP
rs77299114 2347 dbSNP
rs1319606088 2349 dbSNP
rs200619725 2349 dbSNP
rs1054105955 2350 dbSNP
rs1261126416 2352 dbSNP
rs999921955 2353 dbSNP
rs1214382597 2368 dbSNP
rs796551905 2369 dbSNP
rs1485957408 2374 dbSNP
rs1413123199 2377 dbSNP
rs1422312682 2378 dbSNP
rs1045632074 2395 dbSNP
rs948284046 2425 dbSNP
rs1364747438 2428 dbSNP
rs201438684 2428 dbSNP
rs199497813 2441 dbSNP
rs1263840218 2442 dbSNP
rs1209117334 2445 dbSNP
rs929932619 2446 dbSNP
rs1301797274 2450 dbSNP
rs918608402 2455 dbSNP
rs1392795785 2456 dbSNP
rs1307197518 2459 dbSNP
rs746212826 2461 dbSNP
rs1316129564 2462 dbSNP
rs1237777728 2463 dbSNP
rs963127926 2465 dbSNP
rs1280531585 2471 dbSNP
rs911344612 2472 dbSNP
rs766063955 2481 dbSNP
rs1482282322 2483 dbSNP
rs1179173649 2485 dbSNP
rs1317599721 2485 dbSNP
rs775162999 2489 dbSNP
rs1157279162 2492 dbSNP
rs1397238538 2495 dbSNP
rs1435921805 2501 dbSNP
rs1220561766 2507 dbSNP
rs1356945654 2508 dbSNP
rs1010124895 2510 dbSNP
rs1298250644 2515 dbSNP
rs368037890 2519 dbSNP
rs1444097957 2526 dbSNP
rs1446522461 2528 dbSNP
rs576331187 2529 dbSNP
rs139453339 2534 dbSNP
rs36227330 2542 dbSNP
rs1309181526 2545 dbSNP
rs1206785767 2547 dbSNP
rs1399110360 2548 dbSNP
rs1251940493 2552 dbSNP
rs769311652 2557 dbSNP
rs1176960641 2560 dbSNP
rs1167855628 2561 dbSNP
rs759505836 2566 dbSNP
rs905605616 2566 dbSNP
rs1466758742 2568 dbSNP
rs1022735050 2570 dbSNP
rs1181187952 2575 dbSNP
rs1012813865 2577 dbSNP
rs1238984744 2582 dbSNP
rs1170596246 2583 dbSNP
rs573671598 2587 dbSNP
rs1398868284 2588 dbSNP
rs1463753083 2590 dbSNP
rs1327428280 2594 dbSNP
rs1394944894 2601 dbSNP
rs554115144 2604 dbSNP
rs896665319 2606 dbSNP
rs1364048601 2609 dbSNP
rs1215053518 2612 dbSNP
rs1278954257 2614 dbSNP
rs1457439862 2625 dbSNP
rs1256426872 2643 dbSNP
rs373636049 2645 dbSNP
rs1275209731 2650 dbSNP
rs1318667934 2652 dbSNP
rs930212644 2656 dbSNP
rs897123926 2669 dbSNP
rs1487161857 2676 dbSNP
rs1187560960 2701 dbSNP
rs1422304174 2702 dbSNP
rs1289312258 2705 dbSNP
rs1166456049 2717 dbSNP
rs1038372166 2724 dbSNP
rs1404371023 2730 dbSNP
rs941410544 2739 dbSNP
rs1346705307 2745 dbSNP
rs540408517 2747 dbSNP
rs578044190 2754 dbSNP
rs911278549 2769 dbSNP
rs985591853 2775 dbSNP
rs1216953196 2785 dbSNP
rs1295193551 2792 dbSNP
rs1227096326 2815 dbSNP
rs933792741 2826 dbSNP
rs1381975312 2832 dbSNP
rs183922126 2836 dbSNP
rs781662705 2837 dbSNP
rs1217991560 2839 dbSNP
rs1446533111 2841 dbSNP
rs1375642845 2842 dbSNP
rs922459968 2844 dbSNP
rs147997992 2845 dbSNP
rs1189505950 2853 dbSNP
rs955946534 2860 dbSNP
rs1472278316 2869 dbSNP
rs1032929107 2875 dbSNP
rs978377475 2877 dbSNP
rs969777359 2878 dbSNP
rs1415896682 2881 dbSNP
rs1358614201 2883 dbSNP
rs1163575987 2886 dbSNP
rs1314888992 2887 dbSNP
rs1341102027 2887 dbSNP
rs1447589017 2906 dbSNP
rs1282573308 2925 dbSNP
rs1353101720 2928 dbSNP
rs1438890899 2937 dbSNP
rs1285727353 2938 dbSNP
rs1236182493 2940 dbSNP
rs1023107774 2955 dbSNP
rs1180727830 2961 dbSNP
rs1014022785 2962 dbSNP
rs1458432392 2963 dbSNP
rs896607280 2973 dbSNP
rs1035193472 2977 dbSNP
rs897409608 2980 dbSNP
rs1177835405 2981 dbSNP
rs1378219486 2983 dbSNP
rs1436542085 2992 dbSNP
rs1323977578 2995 dbSNP
rs1403004418 2996 dbSNP
rs1291257598 2997 dbSNP
rs1414040093 3017 dbSNP
rs1332254774 3026 dbSNP
rs1337804240 3030 dbSNP
rs1240111641 3034 dbSNP
rs747770854 3036 dbSNP
rs1038657859 3037 dbSNP
rs941346218 3040 dbSNP
rs889809667 3041 dbSNP
rs1351935440 3044 dbSNP
rs1274475265 3057 dbSNP
rs1311997282 3058 dbSNP
rs1457969282 3060 dbSNP
rs1050251167 3070 dbSNP
rs1448528646 3074 dbSNP
rs934095796 3074 dbSNP
rs1455364890 3083 dbSNP
rs1377055443 3087 dbSNP
rs1476985700 3090 dbSNP
rs1373615150 3103 dbSNP
rs1170932262 3106 dbSNP
rs1292382245 3106 dbSNP
rs1398677405 3107 dbSNP
rs1330863543 3109 dbSNP
rs1466355564 3109 dbSNP
rs1398565675 3115 dbSNP
rs1433706763 3117 dbSNP
rs922407560 3128 dbSNP
rs988599690 3137 dbSNP
rs1331087957 3156 dbSNP
rs1351509446 3159 dbSNP
rs1303661325 3170 dbSNP
rs1419081743 3171 dbSNP
rs569188392 3172 dbSNP
rs1160236845 3175 dbSNP
rs546525480 3177 dbSNP
rs925856724 3178 dbSNP
rs1266371865 3187 dbSNP
rs1449824330 3191 dbSNP
rs1195176810 3192 dbSNP
rs1425888730 3194 dbSNP
rs572956580 3195 dbSNP
rs978712139 3195 dbSNP
rs554708045 3199 dbSNP
rs1489487332 3209 dbSNP
rs17019903 3210 dbSNP
rs1294532158 3213 dbSNP
rs750189876 3213 dbSNP
rs992952293 3214 dbSNP
rs1320789632 3217 dbSNP
rs142780069 3220 dbSNP
rs34475435 3225 dbSNP
rs1241349480 3229 dbSNP
rs994320012 3235 dbSNP
rs1300207411 3238 dbSNP
rs1245014238 3239 dbSNP
rs1217160937 3247 dbSNP
rs961566385 3257 dbSNP
rs1353923088 3261 dbSNP
rs1369078064 3267 dbSNP
rs1017169628 3268 dbSNP
rs1005822170 3275 dbSNP
rs1261086836 3279 dbSNP
rs868745129 3280 dbSNP
rs1165695532 3283 dbSNP
rs889748694 3286 dbSNP
rs1049760902 3291 dbSNP
rs1160806293 3306 dbSNP
rs998631844 3317 dbSNP
rs901246170 3319 dbSNP
rs546565487 3320 dbSNP
rs934463322 3321 dbSNP
rs1454149012 3326 dbSNP
rs1396262595 3327 dbSNP
rs925806099 3329 dbSNP
rs1174189359 3331 dbSNP
rs1043326278 3337 dbSNP
rs576104844 3343 dbSNP
rs1352949591 3345 dbSNP
rs74519385 3349 dbSNP
rs574848527 3354 dbSNP
rs915847863 3356 dbSNP
rs1484246196 3360 dbSNP
rs992504543 3363 dbSNP
rs959718631 3368 dbSNP
rs556219810 3381 dbSNP
rs1477095647 3386 dbSNP
rs551691069 3389 dbSNP
rs1217760663 3393 dbSNP
rs1360393830 3395 dbSNP
rs1483112407 3397 dbSNP
rs971820183 3408 dbSNP
rs1466163083 3409 dbSNP
rs1301739638 3432 dbSNP
rs1254683107 3434 dbSNP
rs1309756287 3438 dbSNP
rs1375816207 3446 dbSNP
rs961516924 3453 dbSNP
rs1207578892 3455 dbSNP
rs1312683861 3463 dbSNP
rs1313590024 3464 dbSNP
rs11545157 3465 dbSNP
rs1482415537 3475 dbSNP
rs1200704463 3483 dbSNP
rs1239184685 3490 dbSNP
rs1439400421 3492 dbSNP
rs758983402 3493 dbSNP
rs1177154863 3499 dbSNP
rs1217506471 3501 dbSNP
rs1006184322 3503 dbSNP
rs954315106 3512 dbSNP
rs1279980896 3515 dbSNP
rs192585419 3518 dbSNP
rs542943985 3525 dbSNP
rs1378154935 3531 dbSNP
rs1300934244 3537 dbSNP
rs1444392218 3538 dbSNP
rs1029014546 3547 dbSNP
rs1295044692 3547 dbSNP
rs1368260614 3547 dbSNP
rs998127309 3548 dbSNP
rs901192408 3550 dbSNP
rs1220699255 3556 dbSNP
rs1321431062 3556 dbSNP
rs1170001963 3558 dbSNP
rs1053106912 3560 dbSNP
rs1457474244 3566 dbSNP
rs1464165028 3569 dbSNP
rs1425925249 3573 dbSNP
rs1489112692 3574 dbSNP
rs998897640 3592 dbSNP
rs1422466169 3607 dbSNP
rs1423858956 3608 dbSNP
rs904331654 3609 dbSNP
rs1042887362 3611 dbSNP
rs1422533060 3611 dbSNP
rs1166688505 3612 dbSNP
rs948598601 3617 dbSNP
rs1435690417 3618 dbSNP
rs915813065 3621 dbSNP
rs761427203 3623 dbSNP
rs1278899014 3625 dbSNP
rs1057428094 3626 dbSNP
rs1183975453 3629 dbSNP
rs1462335556 3631 dbSNP
rs529528857 3635 dbSNP
rs1292497533 3637 dbSNP
rs539294622 3638 dbSNP
rs1197668622 3640 dbSNP
rs1245552034 3648 dbSNP
rs560327765 3650 dbSNP
rs971770831 3651 dbSNP
rs963134390 3657 dbSNP
rs1476646973 3664 dbSNP
rs1164579136 3677 dbSNP
rs1228062416 3678 dbSNP
rs1321056208 3680 dbSNP
rs908991153 3684 dbSNP
rs1397586982 3685 dbSNP
rs1362431635 3693 dbSNP
rs1383754532 3695 dbSNP
rs1298915571 3707 dbSNP
rs984305391 3708 dbSNP
rs1330902290 3710 dbSNP
rs1428907554 3710 dbSNP
rs1444908533 3713 dbSNP
rs1286111294 3716 dbSNP
rs1402539807 3722 dbSNP
rs954384178 3730 dbSNP
rs1168568625 3737 dbSNP
rs1217925370 3742 dbSNP
rs146130502 3744 dbSNP
rs13143049 3753 dbSNP
rs1444708793 3755 dbSNP
rs1189012554 3757 dbSNP
rs1237752147 3762 dbSNP
rs1457792451 3766 dbSNP
rs766391236 3767 dbSNP
rs1040721078 3770 dbSNP
rs1367256522 3778 dbSNP
rs538042377 3779 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 54726.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 54726.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000454497.2 | 3UTR | AGAAGUGCUUGAAAGAGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000454497.2 | 3UTR | GAAGUGCUUGAAAGAGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000454497.2 | 3UTR | GAAGUGCUUGAAAGAGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
169 hsa-miR-4778-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT199338 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT203028 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT260646 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT336468 SRP9 signal recognition particle 9 2 2
MIRT389212 SERTAD2 SERTA domain containing 2 2 2
MIRT441814 TENM1 teneurin transmembrane protein 1 2 2
MIRT444029 GREM1 gremlin 1, DAN family BMP antagonist 2 4
MIRT454171 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT469663 RABEPK Rab9 effector protein with kelch motifs 2 2
MIRT495579 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT498340 PRELID2 PRELI domain containing 2 2 2
MIRT498696 LYRM2 LYR motif containing 2 2 6
MIRT504156 OPN5 opsin 5 2 4
MIRT506321 OTUD4 OTU deubiquitinase 4 2 4
MIRT507608 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT525431 PROX2 prospero homeobox 2 2 2
MIRT526973 PAX7 paired box 7 2 2
MIRT527814 TMEM74B transmembrane protein 74B 2 2
MIRT527960 MTAP methylthioadenosine phosphorylase 2 2
MIRT528083 NOL9 nucleolar protein 9 2 2
MIRT528480 STAMBPL1 STAM binding protein like 1 2 2
MIRT528947 PNMA5 paraneoplastic Ma antigen family member 5 2 2
MIRT530687 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT531733 SLC2A9 solute carrier family 2 member 9 2 2
MIRT532445 PLGRKT plasminogen receptor with a C-terminal lysine 2 2
MIRT533331 UNK unkempt family zinc finger 2 2
MIRT534205 SLC38A9 solute carrier family 38 member 9 2 2
MIRT534322 SHISA6 shisa family member 6 2 2
MIRT535197 PLCL1 phospholipase C like 1 (inactive) 2 2
MIRT538076 DIAPH2 diaphanous related formin 2 2 2
MIRT539250 ANKRD50 ankyrin repeat domain 50 2 2
MIRT548733 CREBRF CREB3 regulatory factor 2 2
MIRT556406 LRRC8B leucine rich repeat containing 8 VRAC subunit B 2 2
MIRT559576 AP1AR adaptor related protein complex 1 associated regulatory protein 2 2
MIRT567661 ERGIC2 ERGIC and golgi 2 2 2
MIRT572750 FAM204A family with sequence similarity 204 member A 2 2
MIRT609355 ZNF664 zinc finger protein 664 2 2
MIRT611194 TMEM105 transmembrane protein 105 2 2
MIRT611545 BIRC5 baculoviral IAP repeat containing 5 2 4
MIRT611690 NODAL nodal growth differentiation factor 2 2
MIRT611810 FCRL4 Fc receptor like 4 2 2
MIRT612746 MYOCD myocardin 2 2
MIRT614177 FAM53B family with sequence similarity 53 member B 2 2
MIRT614431 TAZ tafazzin 2 2
MIRT614586 SDC1 syndecan 1 2 2
MIRT615547 TNFSF15 TNF superfamily member 15 2 2
MIRT615872 BRD3 bromodomain containing 3 2 2
MIRT615970 ASCL1 achaete-scute family bHLH transcription factor 1 2 2
MIRT616024 PRRG4 proline rich and Gla domain 4 2 4
MIRT616242 NFIC nuclear factor I C 2 2
MIRT616282 HMGB1 high mobility group box 1 2 2
MIRT616674 PRR15 proline rich 15 2 2
MIRT618302 COL4A4 collagen type IV alpha 4 chain 2 2
MIRT618657 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT618754 SLC38A5 solute carrier family 38 member 5 2 2
MIRT619505 TXLNB taxilin beta 2 2
MIRT619545 GABRG2 gamma-aminobutyric acid type A receptor gamma2 subunit 2 2
MIRT619605 MKKS McKusick-Kaufman syndrome 2 2
MIRT619804 CDC42EP4 CDC42 effector protein 4 2 2
MIRT619923 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT620442 SEMA3E semaphorin 3E 2 4
MIRT620730 CCL16 C-C motif chemokine ligand 16 2 2
MIRT625345 TAPBP TAP binding protein 2 2
MIRT627510 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2 2
MIRT632584 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT636901 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT637873 UTP6 UTP6, small subunit processome component 2 2
MIRT639011 ABI2 abl interactor 2 2 2
MIRT639054 FPR1 formyl peptide receptor 1 2 2
MIRT639085 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639589 RGS5 regulator of G protein signaling 5 2 2
MIRT639718 NPRL3 NPR3 like, GATOR1 complex subunit 2 2
MIRT639904 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT640392 ZNF785 zinc finger protein 785 2 2
MIRT640786 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT641290 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641442 PELO pelota mRNA surveillance and ribosome rescue factor 2 2
MIRT642426 STAT3 signal transducer and activator of transcription 3 2 2
MIRT642682 KRT74 keratin 74 2 2
MIRT643362 TRIM10 tripartite motif containing 10 2 2
MIRT643982 DUSP28 dual specificity phosphatase 28 2 2
MIRT644466 ZNF747 zinc finger protein 747 2 2
MIRT644561 SPOP speckle type BTB/POZ protein 2 2
MIRT645748 FAM213A family with sequence similarity 213 member A 2 2
MIRT646737 FADS1 fatty acid desaturase 1 2 2
MIRT647446 SIX6 SIX homeobox 6 2 2
MIRT648317 SCNN1G sodium channel epithelial 1 gamma subunit 2 2
MIRT649327 POLG DNA polymerase gamma, catalytic subunit 2 2
MIRT649453 WDR70 WD repeat domain 70 2 2
MIRT650066 CCDC134 coiled-coil domain containing 134 2 2
MIRT650156 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT650317 TMX4 thioredoxin related transmembrane protein 4 2 2
MIRT650429 BBS9 Bardet-Biedl syndrome 9 2 2
MIRT651325 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651843 USP13 ubiquitin specific peptidase 13 2 2
MIRT652532 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT652816 TARDBP TAR DNA binding protein 2 2
MIRT652971 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT653466 SLC5A12 solute carrier family 5 member 12 2 4
MIRT653568 SLC35B3 solute carrier family 35 member B3 2 2
MIRT655678 NUMBL NUMB like, endocytic adaptor protein 2 2
MIRT656785 KPNA4 karyopherin subunit alpha 4 2 2
MIRT656798 KNTC1 kinetochore associated 1 2 2
MIRT656988 KDM5A lysine demethylase 5A 2 2
MIRT657292 HOXB5 homeobox B5 2 2
MIRT657497 HBEGF heparin binding EGF like growth factor 2 4
MIRT658012 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT658146 STXBP2 syntaxin binding protein 2 2 2
MIRT658259 FAXC failed axon connections homolog 2 2
MIRT659051 DGKH diacylglycerol kinase eta 2 2
MIRT659171 DCTN3 dynactin subunit 3 2 2
MIRT659936 CACHD1 cache domain containing 1 2 2
MIRT660079 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT660167 BNIP3L BCL2 interacting protein 3 like 2 2
MIRT660292 BICC1 BicC family RNA binding protein 1 2 2
MIRT660317 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT660340 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT660447 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT661634 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662438 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664202 TBCA tubulin folding cofactor A 2 2
MIRT666436 SH2B3 SH2B adaptor protein 3 2 2
MIRT666666 RBM47 RNA binding motif protein 47 2 4
MIRT669253 C4orf36 chromosome 4 open reading frame 36 2 2
MIRT669502 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT693912 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT700435 PURB purine rich element binding protein B 2 2
MIRT702857 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT708857 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709030 KBTBD13 kelch repeat and BTB domain containing 13 2 2
MIRT709609 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT709810 AR androgen receptor 2 2
MIRT709872 A1CF APOBEC1 complementation factor 2 2
MIRT710208 ENAH ENAH, actin regulator 2 2
MIRT710964 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711173 EMCN endomucin 2 2
MIRT711219 RETSAT retinol saturase 2 2
MIRT711345 FMNL2 formin like 2 2 2
MIRT711441 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT711631 PEBP1 phosphatidylethanolamine binding protein 1 2 2
MIRT711823 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 2
MIRT712164 SURF4 surfeit 4 2 2
MIRT712632 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713692 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT714906 CHMP3 charged multivesicular body protein 3 2 2
MIRT715161 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT715430 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT715660 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT715968 FADS3 fatty acid desaturase 3 2 2
MIRT716203 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716234 SRSF12 serine and arginine rich splicing factor 12 2 2
MIRT716251 PALM2 paralemmin 2 2 2
MIRT716375 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT716490 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT716744 APOL6 apolipoprotein L6 2 2
MIRT717624 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT718480 TMEM151A transmembrane protein 151A 2 2
MIRT718805 PRKCB protein kinase C beta 2 2
MIRT719276 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT719432 NPTX2 neuronal pentraxin 2 2 2
MIRT721011 ZNF619 zinc finger protein 619 2 2
MIRT721819 HEATR5A HEAT repeat containing 5A 2 2
MIRT721997 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT723143 METTL24 methyltransferase like 24 2 2
MIRT723213 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT723427 MC2R melanocortin 2 receptor 2 2
MIRT723436 ADI1 acireductone dioxygenase 1 2 2
MIRT723542 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT724474 MMD monocyte to macrophage differentiation associated 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4778-3p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4778-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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