pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol HS3ST3B1   
Synonyms 3-OST-3B, 3OST3B1, h3-OST-3B
Description heparan sulfate-glucosamine 3-sulfotransferase 3B1
Transcript NM_006041   
Expression
Putative miRNA Targets on HS3ST3B1
3'UTR of HS3ST3B1
(miRNA target sites are highlighted)
>HS3ST3B1|NM_006041|3'UTR
   1 GCAGACCCGGGCTATGTACCTTACCCACGTGGCTTATCTATTGACAGAGATTATATGTATGTAAAATGTACAGAAATCTA
  81 TTTTATAATAATTTATTTTTAATTCATAAGCAATTAATTCACTAAGCTGCCTAGCCACACTCTTTAGAGAGTTAGCTTCA
 161 TAATCTGTTAACATTCCAAAGTGTTTAACTCTAGTATTTCGTTCTCTTCTTCACAATTGATGGTGCTTCTATTTTTTCTT
 241 CTCCCCTACCTGTTATATTTAAAACAAAGAAAAGCACAACTTGAGATTTTTGTTGTTACGGGTATTCAGCCTTCAGTCAC
 321 CGTCTGAGTTCTCCAGTTGCTGCCTCCTTGTCTTGTCTTGGGTCTCCCATTCCAGCTTCCCTGTCTCTTCCTGCCTGTGT
 401 ACCTCGTAGGAACGCTGAGCTGCCTCAACAGGGCTGTATTCTGAAGGGCAGGCCTCATGCAGCAGCCTCCTTGCAGATGT
 481 GGTGTCCCGTCCAATGATGTAGCCTGAAAGCCACAGCCCTAGGGTTCTGTCCCTCCCTCCATTCAGCACATGGGGAAATT
 561 TCTCACTCCCTTTACAGGGACATCCACATCCTTTTTTTTTCTTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTC
 641 TTGTTGCCCAGGCTGGGGCGTAATGGTGTGATATATGCTTACCACAACCTCTGGCTCCCGGTTCAAGCGATTCTCCTGTC
 721 TCAGCCTCCCAAGTATCTGGGATTACAGGCATGCACCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGACGGGGTTT
 801 CTTCATGTTGGTCAGGCTGGTATCAAACTCCCGACCTCAGGTGATCCGCCTGCCTTGGCCTCCAAAGTGTTGGGATTATA
 881 GGCGTGAGCCACTGCGCCCGCTATCCACATCCTTCTAGAGTCAGAATGGTAGGGTCTGTTGACTTCAGCTTTTGATTTTG
 961 CAGGATGGCCCTGTGTCCTCCTCTGCCCCATTCCCTGGTTCATTAACCAGTTTGAAGTGTATGTAGATTGTTGCCCCGTC
1041 TTTCCCAGGTCACATGTGTGAGATGCCTGGGTGCTGCTTCAGAAATCAAGATGATCTCCTTTAATTTGCATGAAACTACA
1121 CCATGCTGCGTTCCCCAGGCAGACAGTTCTGCTTTGACACACCAAAGAATCCCGTAGGCTAGCAGAGCCACCAGCACAAA
1201 CCAAGGGCGCTGGGTGTCGAGACTCAGAGGGGTCAGCTGTGTCCCTCGGCATCAGCGTCTACCAAGGTGCTGCTAGGTAC
1281 AGAGCCAGCCAGTGTTGGGCAGCAGGCTCACAGCCTCAATAGGGAGAAAAGACAAAGGCCTCAAAATGACAGGCAGCCTG
1361 ACAGAGGAAGGAGTCTGACACCTCAGCTTGATGCGTCTTTGGAATTCCTAGCTCATCTCAGAATTATATCTTAGAGTGAT
1441 AATATGGGTGGTAGCCAGTGGCCAAACAGCAAGAACTAAGAGTGGCCCTTGCAAAAAAAGGTTGGGAAAGCTGGGCCCAT
1521 ATTGCCTGTAAACCCTTGAGCCTGATGCTCATACAGCTGTCCCTTGTTTTAGCCAGGTCTTGACAGAAGGGTTACCAGCA
1601 CTGTCACTGCTCTACAGAATGCTCTCCCCGTGCCTCTCTGTTGATTTATAACAGTTGGGTAACCAGATAGCAATATAGTG
1681 GCAATTGAGTAGCCATATAGTAATACAGGGGCAGTTGGTTAAACATATAGCAATATCACATAATGATATGTTTAATTTAA
1761 CCTCAGTTTTTTAAACCAGAATGCTTCTACCATAAAAGAATTGTGATTTCAGTTATACTTCCATCAAGGAATATGTGGGA
1841 AGATATACATATTGTCAAAATGGTTGGGATGGGATAGTTACAAAGGACACTTTTGTATGTTGTATGGGATCACTTGCCTG
1921 ATAGTATAAGGAACATTGTATGAAAAGATGAAAAGATACTTCATTTTTAGAAACTGATCAGAGATGTCACTGGTCTTTAA
2001 GTGATGTCTTGAAAATCCAGTATGTATTTGCCCAAAAGTTTTAGCCTACATCTAGCTAGCTTACACTTAGCAGCCAAACC
2081 ATCATTGTGTAGGTTCTGTTTTGGAGGAAGCTCATGGGGGATCTGTGTATTTCTTAGGTTTCTCCCTGTTCTCCAATGTT
2161 TTATCCATTTCGTAGCTTTTTTACTGTCTCCAGAAAGTAGTGTGGGACCTGCACTTAGGGGAATACCAGAATCATAGCGT
2241 GGTTCTGCCTTCTTGATGAGTGATTGTGAAAAACACCTGCATAAGGGTGCTAATTGGTTGTGTATTTTTTCATTTATTTG
2321 AAATCAAACTGAGAACACCTCTTTTCGGTTTACAGCATAACATGGCTTGAAGTAAAAGGCAGTATCCAAGTCCTTCACCT
2401 GGTCTTGCCCTGTCTACTTTCTGATCATTCTGATGGTCTGATGTGGCTGTTGATGTGGAACTGCAGAAGAGTTCAGAGAA
2481 GAGTATGCAACAAAGCCATAGGAAAACACACAGGAGCTTTTCCCTCCCCTTCAGGTCCCCGCCCTCTTTCCAAGCTGGAC
2561 AATTTTTTATTAAGTTGTTTATTCCCTGCCTTAAAACTGAAACAGGAAATTTTCTGGTAGAAGGAGGGTCATTTAGTCAC
2641 GAACACTGAAGTGGGTCAAAATTCTATTCTGGGTCAAATCCTTGAATTCAAACAGATGTCCATAATCAGTACTGATGGAA
2721 TAGAGCAAGTTTTTCTATGTAAGACAAATAAATCAAACATCATGTGCATCTCCTCATAAGGGTCTGCAAGGGTCTGATGG
2801 TTTAAAGTTCCTAACAGATCTGGTTGCAGCATCTGCCGGAGCTTGCACCCCATCATCGGACGGTCATCTTCCTGCTGCAG
2881 AAGTTAGGTAACATAAGACTTAGATTTCTTCCTGTTCTAGCAATCTGCAAGACCACCAGGCTTAACTTTTTAGCTGCCAG
2961 AAGACAAACCCCCTTTTCTGTTTCGGCAATTTGTCCTGGCACGTGTTTTGGACTTCCTCCGATTTACACGAAAAGCTCTG
3041 ATATTCATTGGAGTACTTTATTTTTTTTCCTCAGTTTTGTTTCTTTTCTCATGTAAAAACAAACAAAAAGGTCAACAAAA
3121 AAAAATTGAGGTTTTTCTTGTTTCTATCTAGTTCATGCTTTCTTTGCGGTGTTTGAACAGTAGTCTGTTAACTTAGTAGG
3201 TGGTACCTGGAAAGGTATTTTAAGTATAGTGACTGTTTAATAAATACTTAATTGGATGATGGAGGAGGAGAAATTGTTTT
3281 CTTCCCAGGATTCTCTTTGGGGGTCATTTTGTGTGACAGATATATTTTAGACATTTGGAGAAACAGTTTCAGATCCTGCC
3361 AGGATATTTTTGTAAAAAAGGAAAATGGAAGATTCCAATAAACTAGAAACAGTACGTATCTAAGATGCTGACACAGAAGC
3441 TAATGTGACTTTTCAGCTTATCAAGAGGATGGCCAATAAAACTTAAAGGTGTGGTTAGATGTTTTCTCACTTTTGTGACA
3521 TTAATTTATCACTGAGTCTCATTCAACCAAGTAATCTAAAATACTGTGCAAATTCTAGCAGTATGTCTTCGATAACTTGG
3601 ATGTTAGGATAGCCAATATGTACAAAAAATTAAATCAAGTATTTTGTCCTATGTATAACACAAATTAATTTTACACAGAG
3681 AAAGATGTTTCTAGGCAAGTGAAATTCTGGTAATTCATACTATTTCTTTGTATGAACAAATAAAATATATTTTGCCAAAA
3761 AAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuUAGUGU-UUAC---AGGAAUUAuc 5'
            |||||| ||||   | :|||||  
Target 5' atATCACATAATGATATGTTTAATtt 3'
1733 - 1758 136.00 -8.40
2
miRNA  3' cuUAGUGUUU--ACAG--GAAUUAUc 5'
            | ||  |:  |||:  ||||:|| 
Target 5' tgAACAGTAGTCTGTTAACTTAGTAg 3'
3174 - 3199 132.00 -12.20
3
miRNA  3' cuuagUGUUUACAGGAAUUAuc 5'
               |||:|||||| ||||  
Target 5' ttcaaACAGATGTCCATAATca 3'
2687 - 2708 129.00 -13.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM5616895 1 COSMIC
COSN26979297 2 COSMIC
COSN31581728 50 COSMIC
COSN31600389 50 COSMIC
COSN19736422 59 COSMIC
COSN30156202 74 COSMIC
COSN26979296 76 COSMIC
COSN24388690 96 COSMIC
COSN30176470 112 COSMIC
COSN6651658 205 COSMIC
COSN31480701 270 COSMIC
COSN8674014 323 COSMIC
COSN28201345 607 COSMIC
COSN8831821 855 COSMIC
COSN6651659 938 COSMIC
COSN30272518 939 COSMIC
COSN6651660 1174 COSMIC
COSN6651661 1191 COSMIC
COSN20162118 1209 COSMIC
COSN9655926 1216 COSMIC
COSN20824501 1383 COSMIC
COSN24613505 1616 COSMIC
COSN20333888 1725 COSMIC
COSN6651663 1726 COSMIC
COSN6651664 1816 COSMIC
COSN21651818 2287 COSMIC
COSN6099367 2422 COSMIC
COSN17902532 2855 COSMIC
COSN20163604 2985 COSMIC
COSN28276137 3069 COSMIC
COSN15829034 3268 COSMIC
COSN15816481 3633 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776076623 4 dbSNP
rs761278921 8 dbSNP
rs754293779 9 dbSNP
rs764914123 10 dbSNP
rs1364052738 13 dbSNP
rs750091083 14 dbSNP
rs1311428439 23 dbSNP
rs759827131 29 dbSNP
rs767867893 33 dbSNP
rs753168160 34 dbSNP
rs756650828 38 dbSNP
rs1353436309 39 dbSNP
rs1012901355 40 dbSNP
rs778394495 47 dbSNP
rs754020027 48 dbSNP
rs559784701 50 dbSNP
rs1174054266 58 dbSNP
rs1399032383 60 dbSNP
rs1003098911 61 dbSNP
rs966263458 72 dbSNP
rs1266169748 73 dbSNP
rs1360786412 82 dbSNP
rs972086588 86 dbSNP
rs1031763312 87 dbSNP
rs1265033522 108 dbSNP
rs1433635053 111 dbSNP
rs1269576366 112 dbSNP
rs1026309486 114 dbSNP
rs1175506912 118 dbSNP
rs1480450081 129 dbSNP
rs1477998359 130 dbSNP
rs1200975511 132 dbSNP
rs956218548 134 dbSNP
rs1181100818 136 dbSNP
rs1234604065 137 dbSNP
rs1314390650 139 dbSNP
rs1411453334 143 dbSNP
rs865851156 148 dbSNP
rs370347573 152 dbSNP
rs764288070 155 dbSNP
rs1389133887 157 dbSNP
rs1375742595 162 dbSNP
rs1331581093 163 dbSNP
rs952147709 165 dbSNP
rs528974309 169 dbSNP
rs542208941 179 dbSNP
rs1171721871 180 dbSNP
rs1466509600 186 dbSNP
rs1344164057 190 dbSNP
rs1157067023 192 dbSNP
rs1417452825 196 dbSNP
rs909717053 202 dbSNP
rs3785655 205 dbSNP
rs531246835 207 dbSNP
rs975076786 210 dbSNP
rs1460094697 215 dbSNP
rs991833316 246 dbSNP
rs192265339 247 dbSNP
rs1484543498 258 dbSNP
rs1283999721 262 dbSNP
rs572941057 290 dbSNP
rs933855817 294 dbSNP
rs986723013 295 dbSNP
rs949958646 300 dbSNP
rs1380059522 301 dbSNP
rs908492711 311 dbSNP
rs752503979 312 dbSNP
rs902816334 317 dbSNP
rs140530925 322 dbSNP
rs898567543 323 dbSNP
rs1353150457 337 dbSNP
rs1054180691 345 dbSNP
rs527466817 346 dbSNP
rs1188730580 347 dbSNP
rs1007749234 349 dbSNP
rs1260331384 351 dbSNP
rs1288343849 362 dbSNP
rs1216529093 363 dbSNP
rs907201780 367 dbSNP
rs1019517479 369 dbSNP
rs1218117478 373 dbSNP
rs902130060 377 dbSNP
rs993746545 382 dbSNP
rs1235569773 383 dbSNP
rs1473716820 385 dbSNP
rs1342041319 390 dbSNP
rs1182437770 393 dbSNP
rs1026322509 406 dbSNP
rs1399335983 407 dbSNP
rs1437209888 414 dbSNP
rs1422786813 415 dbSNP
rs1390351398 423 dbSNP
rs1159968368 427 dbSNP
rs1164033330 436 dbSNP
rs1360715796 450 dbSNP
rs951992619 454 dbSNP
rs143800784 462 dbSNP
rs1022221988 465 dbSNP
rs1357856859 470 dbSNP
rs73979332 471 dbSNP
rs111483747 483 dbSNP
rs573466796 483 dbSNP
rs1376815756 485 dbSNP
rs959705678 486 dbSNP
rs1288791573 488 dbSNP
rs991368618 489 dbSNP
rs1357951570 490 dbSNP
rs955016431 491 dbSNP
rs536753531 493 dbSNP
rs949971803 495 dbSNP
rs1361013767 496 dbSNP
rs1403244002 499 dbSNP
rs1330591153 514 dbSNP
rs1218901196 515 dbSNP
rs75346727 516 dbSNP
rs924290718 522 dbSNP
rs973906193 524 dbSNP
rs1170464547 532 dbSNP
rs935654616 533 dbSNP
rs1426489100 537 dbSNP
rs1443875169 537 dbSNP
rs1210568044 538 dbSNP
rs1477951798 545 dbSNP
rs1245635878 547 dbSNP
rs1237456612 548 dbSNP
rs1456405941 549 dbSNP
rs1054510130 551 dbSNP
rs1198890362 559 dbSNP
rs1453000428 563 dbSNP
rs1235940292 566 dbSNP
rs1197831948 570 dbSNP
rs1318320832 578 dbSNP
rs1380422789 580 dbSNP
rs919773219 581 dbSNP
rs1217410160 583 dbSNP
rs1344157639 588 dbSNP
rs1170507635 591 dbSNP
rs1275550654 592 dbSNP
rs1330922335 592 dbSNP
rs1334254404 592 dbSNP
rs371707443 592 dbSNP
rs1426844224 597 dbSNP
rs1448074393 598 dbSNP
rs1402916972 599 dbSNP
rs1414420688 600 dbSNP
rs943103531 600 dbSNP
rs1426437582 601 dbSNP
rs372408601 601 dbSNP
rs1207711092 602 dbSNP
rs1239802613 602 dbSNP
rs1241172780 602 dbSNP
rs1279217801 602 dbSNP
rs1301488974 602 dbSNP
rs1308542338 602 dbSNP
rs1351600319 602 dbSNP
rs1360295525 602 dbSNP
rs1375717420 602 dbSNP
rs1441810811 602 dbSNP
rs1447716231 602 dbSNP
rs144999880 602 dbSNP
rs71352467 602 dbSNP
rs869092789 602 dbSNP
rs948794296 602 dbSNP
rs1336702699 604 dbSNP
rs1358077152 605 dbSNP
rs1415749123 605 dbSNP
rs1044883539 606 dbSNP
rs1381747391 606 dbSNP
rs1487237250 607 dbSNP
rs796810561 607 dbSNP
rs866949263 607 dbSNP
rs1491135672 608 dbSNP
rs796751951 608 dbSNP
rs1380342590 609 dbSNP
rs993758181 609 dbSNP
rs1026539722 610 dbSNP
rs565405147 610 dbSNP
rs1362131281 611 dbSNP
rs1445275928 611 dbSNP
rs887796056 612 dbSNP
rs1006247594 613 dbSNP
rs1414280141 615 dbSNP
rs1053076154 616 dbSNP
rs1262345614 619 dbSNP
rs570031463 619 dbSNP
rs1232785508 622 dbSNP
rs386385732 623 dbSNP
rs1273237286 624 dbSNP
rs1489303016 624 dbSNP
rs1356887575 625 dbSNP
rs1221050094 626 dbSNP
rs1291955846 627 dbSNP
rs892015696 628 dbSNP
rs1322493949 633 dbSNP
rs1315955318 635 dbSNP
rs1200525862 637 dbSNP
rs1238238711 638 dbSNP
rs1292493995 644 dbSNP
rs1217150306 647 dbSNP
rs1340500821 653 dbSNP
rs1450481415 660 dbSNP
rs1196137611 661 dbSNP
rs1363462496 665 dbSNP
rs530892527 667 dbSNP
rs1435340157 668 dbSNP
rs1350072981 672 dbSNP
rs1248052860 673 dbSNP
rs1166875209 675 dbSNP
rs750747389 684 dbSNP
rs1034086445 685 dbSNP
rs184286899 700 dbSNP
rs1478723509 701 dbSNP
rs1043189385 702 dbSNP
rs559190633 703 dbSNP
rs1024099180 706 dbSNP
rs1177570629 709 dbSNP
rs971174156 710 dbSNP
rs1248650196 716 dbSNP
rs1197210336 717 dbSNP
rs1317680794 732 dbSNP
rs572422856 734 dbSNP
rs1259035033 737 dbSNP
rs1221020480 739 dbSNP
rs1310912291 740 dbSNP
rs977324493 745 dbSNP
rs924551999 755 dbSNP
rs900675326 756 dbSNP
rs996391968 757 dbSNP
rs534864175 759 dbSNP
rs1173519929 768 dbSNP
rs989865302 787 dbSNP
rs1210011715 789 dbSNP
rs910205973 794 dbSNP
rs1386247182 795 dbSNP
rs943134156 802 dbSNP
rs1463482911 806 dbSNP
rs1375819625 812 dbSNP
rs1321698332 817 dbSNP
rs1433832232 823 dbSNP
rs1333029801 825 dbSNP
rs1405826359 829 dbSNP
rs955131929 831 dbSNP
rs1040114130 833 dbSNP
rs151119500 834 dbSNP
rs929436909 839 dbSNP
rs1047910220 844 dbSNP
rs573358399 848 dbSNP
rs542695415 849 dbSNP
rs1312258276 863 dbSNP
rs1191670414 874 dbSNP
rs1237525039 879 dbSNP
rs974400797 880 dbSNP
rs1309751007 883 dbSNP
rs1055172594 885 dbSNP
rs895103383 889 dbSNP
rs1013682131 896 dbSNP
rs1024989201 897 dbSNP
rs966744511 898 dbSNP
rs919737673 900 dbSNP
rs573032790 901 dbSNP
rs1192568290 910 dbSNP
rs980000950 913 dbSNP
rs1184480553 922 dbSNP
rs530268190 925 dbSNP
rs1031457606 927 dbSNP
rs1262900936 929 dbSNP
rs957348423 930 dbSNP
rs1477010688 931 dbSNP
rs928707513 932 dbSNP
rs575969106 933 dbSNP
rs938778343 934 dbSNP
rs8078587 938 dbSNP
rs913236736 939 dbSNP
rs1352580022 945 dbSNP
rs910227912 965 dbSNP
rs964703660 966 dbSNP
rs975848398 970 dbSNP
rs1338493078 974 dbSNP
rs947629254 984 dbSNP
rs1161506045 990 dbSNP
rs1296470283 994 dbSNP
rs1393056875 1000 dbSNP
rs1419150554 1004 dbSNP
rs1361472725 1007 dbSNP
rs923039532 1012 dbSNP
rs1425523819 1019 dbSNP
rs1043692449 1022 dbSNP
rs755230311 1026 dbSNP
rs1476490391 1032 dbSNP
rs1261614075 1036 dbSNP
rs755648816 1038 dbSNP
rs189441729 1039 dbSNP
rs528141865 1042 dbSNP
rs1353766135 1045 dbSNP
rs942300663 1047 dbSNP
rs1245211500 1048 dbSNP
rs116553485 1050 dbSNP
rs181959777 1052 dbSNP
rs1013561479 1057 dbSNP
rs1237746237 1065 dbSNP
rs1341212426 1066 dbSNP
rs1359602410 1070 dbSNP
rs1215270092 1073 dbSNP
rs185429837 1093 dbSNP
rs1390236117 1098 dbSNP
rs1164238903 1107 dbSNP
rs1463323733 1111 dbSNP
rs529894884 1112 dbSNP
rs902639699 1116 dbSNP
rs1219223545 1122 dbSNP
rs141020580 1123 dbSNP
rs1027316501 1124 dbSNP
rs1194649585 1130 dbSNP
rs570087518 1131 dbSNP
rs553958420 1133 dbSNP
rs1214162895 1147 dbSNP
rs928487298 1150 dbSNP
rs1255840242 1155 dbSNP
rs1370717228 1160 dbSNP
rs1445244594 1165 dbSNP
rs1217948531 1170 dbSNP
rs11078241 1174 dbSNP
rs1272030447 1175 dbSNP
rs72820616 1180 dbSNP
rs565983458 1181 dbSNP
rs1017915599 1183 dbSNP
rs1398577105 1189 dbSNP
rs386795663 1189 dbSNP
rs1289197117 1190 dbSNP
rs8077723 1191 dbSNP
rs1043085556 1197 dbSNP
rs922164243 1201 dbSNP
rs1169197234 1210 dbSNP
rs1476750869 1215 dbSNP
rs1376777625 1217 dbSNP
rs975777735 1219 dbSNP
rs374666104 1220 dbSNP
rs115034702 1245 dbSNP
rs1455257165 1248 dbSNP
rs950487952 1249 dbSNP
rs983161852 1252 dbSNP
rs759225920 1256 dbSNP
rs574687008 1257 dbSNP
rs990983960 1258 dbSNP
rs1344405123 1261 dbSNP
rs916844201 1262 dbSNP
rs1374901728 1263 dbSNP
rs1036776805 1271 dbSNP
rs949630826 1278 dbSNP
rs1412604604 1288 dbSNP
rs896944326 1289 dbSNP
rs995564930 1293 dbSNP
rs1414330509 1296 dbSNP
rs764859848 1301 dbSNP
rs1173660778 1309 dbSNP
rs1483096801 1312 dbSNP
rs537273532 1314 dbSNP
rs1199097988 1321 dbSNP
rs905749541 1324 dbSNP
rs1258824923 1326 dbSNP
rs1462171493 1327 dbSNP
rs1001407295 1337 dbSNP
rs1178075834 1339 dbSNP
rs72250865 1353 dbSNP
rs1441724351 1357 dbSNP
rs1281170580 1364 dbSNP
rs775337378 1374 dbSNP
rs1441771908 1376 dbSNP
rs902482020 1382 dbSNP
rs2200000 1393 dbSNP
rs988643692 1394 dbSNP
rs180836236 1395 dbSNP
rs764084451 1396 dbSNP
rs544961023 1413 dbSNP
rs1011849168 1415 dbSNP
rs564883375 1422 dbSNP
rs1447967863 1434 dbSNP
rs921975451 1437 dbSNP
rs1313001321 1438 dbSNP
rs1355086753 1441 dbSNP
rs932187395 1450 dbSNP
rs900456833 1454 dbSNP
rs572112904 1455 dbSNP
rs1157671753 1456 dbSNP
rs1446005170 1464 dbSNP
rs1409915324 1466 dbSNP
rs912183538 1470 dbSNP
rs541330456 1471 dbSNP
rs1258107883 1478 dbSNP
rs1030007206 1483 dbSNP
rs1487344730 1486 dbSNP
rs1036558587 1493 dbSNP
rs1262476089 1493 dbSNP
rs1318910749 1497 dbSNP
rs750021825 1500 dbSNP
rs73979334 1501 dbSNP
rs1336177032 1502 dbSNP
rs1048493526 1503 dbSNP
rs983216326 1504 dbSNP
rs7222164 1514 dbSNP
rs1287731020 1516 dbSNP
rs963144985 1520 dbSNP
rs1346563049 1524 dbSNP
rs865890004 1528 dbSNP
rs377453201 1535 dbSNP
rs991428203 1537 dbSNP
rs1418568470 1548 dbSNP
rs1167010117 1549 dbSNP
rs1265441825 1552 dbSNP
rs1476769515 1557 dbSNP
rs543270106 1560 dbSNP
rs1187146466 1577 dbSNP
rs867808192 1579 dbSNP
rs1424341441 1580 dbSNP
rs1324854849 1592 dbSNP
rs1198643451 1596 dbSNP
rs1236415139 1600 dbSNP
rs1275368917 1601 dbSNP
rs949640370 1603 dbSNP
rs982294824 1604 dbSNP
rs1481623813 1606 dbSNP
rs1294277667 1608 dbSNP
rs1035567928 1612 dbSNP
rs1363706852 1615 dbSNP
rs1291421999 1617 dbSNP
rs1177853492 1630 dbSNP
rs563777549 1631 dbSNP
rs532505482 1634 dbSNP
rs935310843 1636 dbSNP
rs1053775103 1641 dbSNP
rs1010011240 1656 dbSNP
rs1431714410 1659 dbSNP
rs893912325 1660 dbSNP
rs1430371944 1667 dbSNP
rs751571579 1670 dbSNP
rs552110200 1690 dbSNP
rs1177935472 1696 dbSNP
rs565725354 1697 dbSNP
rs1020129199 1699 dbSNP
rs1255321118 1707 dbSNP
rs138002454 1708 dbSNP
rs978872344 1712 dbSNP
rs1168380612 1716 dbSNP
rs1252389560 1718 dbSNP
rs1204683150 1720 dbSNP
rs900299784 1725 dbSNP
rs1859906 1726 dbSNP
rs1292456614 1727 dbSNP
rs987510795 1745 dbSNP
rs1305407834 1747 dbSNP
rs1051655748 1749 dbSNP
rs1365023232 1761 dbSNP
rs77218454 1762 dbSNP
rs1285576129 1767 dbSNP
rs940952860 1771 dbSNP
rs186720939 1773 dbSNP
rs1015920982 1777 dbSNP
rs963498623 1780 dbSNP
rs552896212 1784 dbSNP
rs1024229865 1798 dbSNP
rs1251604557 1799 dbSNP
rs557294476 1806 dbSNP
rs569686333 1808 dbSNP
rs1309811772 1809 dbSNP
rs1482532392 1812 dbSNP
rs917310 1816 dbSNP
rs927074448 1817 dbSNP
rs1348216851 1827 dbSNP
rs143560205 1830 dbSNP
rs188606701 1838 dbSNP
rs924220236 1845 dbSNP
rs956939514 1846 dbSNP
rs1871784 1847 dbSNP
rs1307372346 1848 dbSNP
rs1201941768 1849 dbSNP
rs776526422 1857 dbSNP
rs915245412 1864 dbSNP
rs1393090467 1868 dbSNP
rs552582231 1873 dbSNP
rs368423473 1874 dbSNP
rs1010128074 1877 dbSNP
rs1312403344 1878 dbSNP
rs145746808 1891 dbSNP
rs778201030 1892 dbSNP
rs747522357 1896 dbSNP
rs71366150 1897 dbSNP
rs933162512 1900 dbSNP
rs1364756072 1903 dbSNP
rs1410511702 1905 dbSNP
rs1422627546 1907 dbSNP
rs1051582118 1917 dbSNP
rs886387460 1918 dbSNP
rs1029077828 1921 dbSNP
rs1004797405 1923 dbSNP
rs1214020304 1930 dbSNP
rs879136141 1934 dbSNP
rs780744103 1936 dbSNP
rs1037776434 1937 dbSNP
rs1459108844 1940 dbSNP
rs745422866 1948 dbSNP
rs898797874 1949 dbSNP
rs1012422084 1950 dbSNP
rs79314339 1957 dbSNP
rs766866439 1967 dbSNP
rs1276719797 1971 dbSNP
rs563344599 1982 dbSNP
rs769456391 1989 dbSNP
rs149247238 1991 dbSNP
rs1312080240 1993 dbSNP
rs1003696756 1996 dbSNP
rs545891667 1999 dbSNP
rs1456704717 2002 dbSNP
rs1417859845 2012 dbSNP
rs957216887 2017 dbSNP
rs1224823903 2023 dbSNP
rs1292729297 2024 dbSNP
rs989712811 2028 dbSNP
rs1166294280 2031 dbSNP
rs915237638 2039 dbSNP
rs1419418226 2051 dbSNP
rs1190347663 2053 dbSNP
rs1446115981 2065 dbSNP
rs1214150820 2085 dbSNP
rs1206742534 2088 dbSNP
rs762790671 2090 dbSNP
rs561389792 2095 dbSNP
rs559451248 2097 dbSNP
rs1475697940 2099 dbSNP
rs528454172 2104 dbSNP
rs937104521 2108 dbSNP
rs1056701893 2114 dbSNP
rs916916729 2118 dbSNP
rs1297994657 2119 dbSNP
rs1385240532 2120 dbSNP
rs945934026 2121 dbSNP
rs1326940496 2124 dbSNP
rs1181265586 2125 dbSNP
rs1398708653 2130 dbSNP
rs1411551025 2143 dbSNP
rs1165709456 2144 dbSNP
rs1474791458 2147 dbSNP
rs1445846921 2157 dbSNP
rs1452128390 2165 dbSNP
rs1252175566 2167 dbSNP
rs922709362 2172 dbSNP
rs1469808324 2173 dbSNP
rs1041628321 2177 dbSNP
rs181685853 2182 dbSNP
rs1000016544 2190 dbSNP
rs1417528876 2194 dbSNP
rs1253095087 2204 dbSNP
rs1231368856 2233 dbSNP
rs1370475830 2234 dbSNP
rs1304681336 2236 dbSNP
rs774360934 2239 dbSNP
rs761834675 2240 dbSNP
rs907668946 2243 dbSNP
rs940610995 2250 dbSNP
rs568710068 2259 dbSNP
rs1050716721 2264 dbSNP
rs1432518086 2265 dbSNP
rs531114546 2268 dbSNP
rs1394082015 2271 dbSNP
rs1194096383 2284 dbSNP
rs551297103 2285 dbSNP
rs1009005684 2291 dbSNP
rs77703117 2295 dbSNP
rs148494003 2297 dbSNP
rs71366151 2299 dbSNP
rs71366152 2302 dbSNP
rs1224033572 2305 dbSNP
rs1275244079 2305 dbSNP
rs962029050 2327 dbSNP
rs1347500009 2347 dbSNP
rs186175775 2348 dbSNP
rs560796974 2358 dbSNP
rs1348999095 2366 dbSNP
rs1279285090 2371 dbSNP
rs993942984 2375 dbSNP
rs759574086 2391 dbSNP
rs1330361051 2394 dbSNP
rs1412373088 2404 dbSNP
rs1027886944 2408 dbSNP
rs62056074 2409 dbSNP
rs906326723 2410 dbSNP
rs1238329782 2413 dbSNP
rs1286070042 2423 dbSNP
rs1447304176 2425 dbSNP
rs1234511629 2431 dbSNP
rs7217818 2437 dbSNP
rs1235621957 2440 dbSNP
rs1258242885 2442 dbSNP
rs1213317863 2444 dbSNP
rs757016709 2445 dbSNP
rs1031133007 2450 dbSNP
rs1224659443 2462 dbSNP
rs1291977799 2467 dbSNP
rs926796124 2471 dbSNP
rs1354288298 2473 dbSNP
rs1312903435 2492 dbSNP
rs1416278141 2494 dbSNP
rs1010414312 2497 dbSNP
rs552802366 2500 dbSNP
rs112057771 2503 dbSNP
rs1022523766 2513 dbSNP
rs1162720543 2518 dbSNP
rs751980754 2528 dbSNP
rs1418699234 2533 dbSNP
rs945712816 2535 dbSNP
rs543345777 2541 dbSNP
rs1408278037 2542 dbSNP
rs540545171 2545 dbSNP
rs757761333 2548 dbSNP
rs781590652 2557 dbSNP
rs1455092777 2563 dbSNP
rs907714194 2563 dbSNP
rs935921484 2564 dbSNP
rs530478289 2570 dbSNP
rs973625430 2578 dbSNP
rs1229517844 2585 dbSNP
rs1359505663 2598 dbSNP
rs1269232404 2618 dbSNP
rs920552976 2624 dbSNP
rs888967410 2627 dbSNP
rs745724000 2628 dbSNP
rs947958719 2629 dbSNP
rs1281423348 2639 dbSNP
rs1044748970 2641 dbSNP
rs375176403 2642 dbSNP
rs1426805326 2651 dbSNP
rs1040465781 2652 dbSNP
rs906169997 2655 dbSNP
rs576942509 2658 dbSNP
rs1052106330 2664 dbSNP
rs897953301 2672 dbSNP
rs1251557749 2679 dbSNP
rs993505768 2681 dbSNP
rs1028078722 2682 dbSNP
rs892647230 2691 dbSNP
rs190501385 2696 dbSNP
rs1325551097 2702 dbSNP
rs561493513 2703 dbSNP
rs900118740 2709 dbSNP
rs997060134 2718 dbSNP
rs1202954549 2731 dbSNP
rs1305270744 2739 dbSNP
rs771996441 2744 dbSNP
rs955329217 2754 dbSNP
rs775087846 2755 dbSNP
rs982882139 2760 dbSNP
rs1366873909 2782 dbSNP
rs80319203 2784 dbSNP
rs963105200 2788 dbSNP
rs1439872605 2789 dbSNP
rs960847083 2799 dbSNP
rs1295227162 2802 dbSNP
rs573023595 2805 dbSNP
rs1460353622 2824 dbSNP
rs1354037938 2834 dbSNP
rs1171182495 2836 dbSNP
rs1431906469 2838 dbSNP
rs1393478365 2839 dbSNP
rs1183397901 2842 dbSNP
rs768439001 2846 dbSNP
rs1167841882 2849 dbSNP
rs1233049766 2850 dbSNP
rs1477521599 2851 dbSNP
rs1176006653 2852 dbSNP
rs568738476 2853 dbSNP
rs920420976 2858 dbSNP
rs536054059 2859 dbSNP
rs769213418 2862 dbSNP
rs140064202 2863 dbSNP
rs925609681 2872 dbSNP
rs935907384 2883 dbSNP
rs1422269553 2884 dbSNP
rs1303079187 2892 dbSNP
rs1389639224 2900 dbSNP
rs1372490008 2909 dbSNP
rs62056075 2913 dbSNP
rs1052035126 2921 dbSNP
rs910497098 2924 dbSNP
rs768486876 2929 dbSNP
rs944522055 2934 dbSNP
rs1379763406 2937 dbSNP
rs1040267256 2941 dbSNP
rs1336552133 2942 dbSNP
rs1436073442 2950 dbSNP
rs1409331760 2957 dbSNP
rs897877149 2960 dbSNP
rs1483751108 2968 dbSNP
rs946453519 2983 dbSNP
rs1254702658 2985 dbSNP
rs11552190 2986 dbSNP
rs1485774074 2990 dbSNP
rs761558160 2994 dbSNP
rs550969454 2998 dbSNP
rs887787409 3001 dbSNP
rs1002237872 3003 dbSNP
rs1033874303 3004 dbSNP
rs1197011624 3005 dbSNP
rs1312307088 3017 dbSNP
rs1415667957 3019 dbSNP
rs772014464 3021 dbSNP
rs1051323458 3022 dbSNP
rs1453487810 3022 dbSNP
rs543140358 3030 dbSNP
rs773054429 3031 dbSNP
rs1021084902 3034 dbSNP
rs1415067794 3040 dbSNP
rs1186571444 3043 dbSNP
rs1270609938 3044 dbSNP
rs1424080795 3044 dbSNP
rs967112637 3045 dbSNP
rs1200640256 3048 dbSNP
rs759610310 3049 dbSNP
rs533530233 3050 dbSNP
rs1485425755 3052 dbSNP
rs1032794130 3053 dbSNP
rs1474739098 3057 dbSNP
rs1332548559 3061 dbSNP
rs957244635 3061 dbSNP
rs1292799865 3069 dbSNP
rs1169690525 3071 dbSNP
rs1397383390 3073 dbSNP
rs1233957778 3096 dbSNP
rs1342555229 3097 dbSNP
rs1293702971 3100 dbSNP
rs1381804113 3105 dbSNP
rs143663372 3106 dbSNP
rs1301458352 3110 dbSNP
rs146821691 3112 dbSNP
rs1405279629 3114 dbSNP
rs113896684 3117 dbSNP
rs910465812 3117 dbSNP
rs1277383368 3118 dbSNP
rs1457966541 3120 dbSNP
rs1027498262 3121 dbSNP
rs919104247 3125 dbSNP
rs929378887 3127 dbSNP
rs1427512739 3130 dbSNP
rs1324589551 3138 dbSNP
rs969166612 3139 dbSNP
rs1049599192 3140 dbSNP
rs909321992 3147 dbSNP
rs1214173554 3153 dbSNP
rs980675327 3157 dbSNP
rs927911104 3159 dbSNP
rs1327220386 3162 dbSNP
rs1354965839 3168 dbSNP
rs763150028 3169 dbSNP
rs534714888 3170 dbSNP
rs1327171322 3176 dbSNP
rs1217352815 3184 dbSNP
rs572637960 3188 dbSNP
rs1388975041 3190 dbSNP
rs1392296224 3197 dbSNP
rs548304259 3202 dbSNP
rs139233230 3207 dbSNP
rs1390388860 3209 dbSNP
rs1170323673 3211 dbSNP
rs896706910 3215 dbSNP
rs183400160 3242 dbSNP
rs1042509380 3245 dbSNP
rs921448609 3257 dbSNP
rs751891062 3277 dbSNP
rs1248563917 3298 dbSNP
rs1195285254 3299 dbSNP
rs1343217598 3303 dbSNP
rs1001067876 3304 dbSNP
rs1033175978 3312 dbSNP
rs1051250901 3318 dbSNP
rs1347629500 3318 dbSNP
rs957179353 3335 dbSNP
rs1439268669 3347 dbSNP
rs1334484914 3349 dbSNP
rs1326347605 3350 dbSNP
rs1007199697 3351 dbSNP
rs1370558886 3376 dbSNP
rs1472488454 3386 dbSNP
rs1309485495 3388 dbSNP
rs1017285172 3393 dbSNP
rs1394281080 3399 dbSNP
rs965928844 3406 dbSNP
rs1478997721 3409 dbSNP
rs186993613 3416 dbSNP
rs1004466337 3417 dbSNP
rs1387290260 3427 dbSNP
rs556961902 3439 dbSNP
rs1297352566 3440 dbSNP
rs757597606 3441 dbSNP
rs1485448431 3442 dbSNP
rs1382589143 3443 dbSNP
rs1383719227 3450 dbSNP
rs1221281523 3452 dbSNP
rs1037038508 3459 dbSNP
rs950587492 3463 dbSNP
rs576742915 3468 dbSNP
rs1229486248 3477 dbSNP
rs995620031 3484 dbSNP
rs73257343 3485 dbSNP
rs1374456616 3489 dbSNP
rs191215224 3494 dbSNP
rs1334643076 3517 dbSNP
rs1053326 3522 dbSNP
rs750910163 3523 dbSNP
rs1157943446 3524 dbSNP
rs917932689 3526 dbSNP
rs1414324656 3539 dbSNP
rs1185868179 3540 dbSNP
rs1475035794 3546 dbSNP
rs541916650 3547 dbSNP
rs1034811717 3549 dbSNP
rs1445645703 3552 dbSNP
rs766782213 3556 dbSNP
rs562238182 3564 dbSNP
rs1331797877 3566 dbSNP
rs182542899 3575 dbSNP
rs1020629727 3578 dbSNP
rs1053967954 3589 dbSNP
rs1284429996 3591 dbSNP
rs372969040 3592 dbSNP
rs892853839 3594 dbSNP
rs1324493584 3600 dbSNP
rs1442399843 3602 dbSNP
rs1181798719 3605 dbSNP
rs1457747917 3608 dbSNP
rs1245116021 3616 dbSNP
rs1390722965 3617 dbSNP
rs1007335471 3621 dbSNP
rs1460986862 3629 dbSNP
rs1414554127 3630 dbSNP
rs1158212191 3637 dbSNP
rs1183839600 3653 dbSNP
rs755587962 3660 dbSNP
rs1241934883 3662 dbSNP
rs544607641 3662 dbSNP
rs1189589858 3667 dbSNP
rs979101324 3675 dbSNP
rs1466685082 3683 dbSNP
rs921043208 3686 dbSNP
rs965689206 3695 dbSNP
rs932381737 3701 dbSNP
rs1158954497 3714 dbSNP
rs1289916423 3717 dbSNP
rs779704321 3720 dbSNP
rs1401377476 3733 dbSNP
rs1450404443 3734 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 9953.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 9953.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5 PAR-CLIP data was present in ERX177619. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_9 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760641. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_B ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000360954.2 | 3UTR | UAGUGACUGUUUAAUAAAUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000360954.2 | 3UTR | AGUGACUGUUUAAUAAAUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000360954.2 | 3UTR | UAGUGACUGUUUAAUAAAUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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