pre-miRNA Information | |
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pre-miRNA | hsa-mir-758 |
Genomic Coordinates | chr14: 101026020 - 101026107 |
Synonyms | MIRN758, hsa-mir-758, MIR758 |
Description | Homo sapiens miR-758 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-758-5p | |||||||||||||||||||||||||||||||||||||||||||||
Sequence | 15| GAUGGUUGACCAGAGAGCACAC |36 | |||||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||||||||
Experiments | SOLiD | |||||||||||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | DCTN4 | ||||||||||||||||||||
Synonyms | DYN4, P62 | ||||||||||||||||||||
Description | dynactin subunit 4 | ||||||||||||||||||||
Transcript | NM_001135643 | ||||||||||||||||||||
Other Transcripts | NM_001135644 , NM_016221 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on DCTN4 | |||||||||||||||||||||
3'UTR of DCTN4 (miRNA target sites are highlighted) |
>DCTN4|NM_001135643|3'UTR 1 AAGGTTCCACTGGAGGGCAGATCCCAAAGGACAGTATCACCGTAAACCTGCGTTAAAATGTGGAAGCTGCTGCTTCATTA 81 GGCCTTGTTTATAACGATGTACCCATGCACTACGGAATTCTATTGCTAAGAAAGTGGGAGCATAGGCAAGGCATTGGGAA 161 CACAGGGTAGCTGCTGTTGCTCTTGCTCTCACCCCTGTTGACACCAGTAAGTCTGTGTCTCCCTCACTGAACCCTGCACG 241 TTGAGTAACAGCAGCATAATTCCATCCTAGGAAAGGGGATGGGTGTTCCTTGGAATGGCATTGTATTTACCACCTGAGAA 321 ACTCTGTACTGTCTCTTGATCTGATCTCACTAAGGATCACAATGTCACAGATGAAACTTAAATGATAACCCAAAGGTAGA 401 CCTGCTGTTAATGATCCAGCATTGGTCACAATGTACCAACTGCTTTCTGCATTCCGTTAAATATCATCTAACAGTCTAAA 481 ACATATCCCTTCATTGCCATAATGGCTGCCATTTTGCCATAGATTTCCATATAACTGAAAAACTGAATTGTCACTTTATC 561 TTTAGTATCATGATGATTGGAAAAACCTGTGAAGTTGTTAAGGCACTCTCATTTGCCCTCTTTTTCTAAGTGAATACAGG 641 ACACGTATTAGTTGTTCTTAATTTTTTTCCCAGTAAAATATGGATCTTTTAAGAAGAATTTGAGAAGCAAACAATTACAT 721 GTCATGTCAAGGGGGTAGCAGATTCCATTCGTTTTCAATATTGCCACAATACCCAGGGATTAATGCTGCCACAGGGGGGC 801 AATCTTTATTTGTCTTACTTCCTACCCCTTCCCTGTTCTGCCTCTTTAACTCAGTTAAGTTGTTCTGTTTGGGACCTGGA 881 AAAGAACCCAAAGAAAACCTGAGTGGACAGGTTCATTTCTGGAATGCAGAAAACATTTTAAAGGCTAGATTTTTAGAATA 961 TTCTCAACTAGCATTCTTTCCATTGATTTGAAGGGGAAATTAACTATTATAATCTCTTGAATCCAAAACTGGATATTAAG 1041 AACTTTCCCCCTTACTAAGTTTAAGACTTTTGTCATGTGGTGAGTCAAATAAGACCATTTTGATTGTAAACCATAAAATA 1121 GTTCAGCAAGTAGCCCACAGTTCTGGCCTAACAGCAGACTTGCTGTTTTCACTTGGTATCCTGGAGTTGGGTTGCTAACC 1201 TTAATTTCTATGATGTTTTCTAAAATGAAACTTGATAAAGTAGACCACCAGCTGCACCGTGTTTTCTGTAAAAGTATTGT 1281 TAGTAAGTGGCCAAGAGACTTGAGGAAAATACAGATTTTTTGTTTACCTTGGTCTTGTTTTAAGTCTTAAAAAATTAAAG 1361 ATAACATTATAATGTAGAATACAGATGGGACATAGTCCTTGTAAGCTTCCCTTGAAAATGTTTTAAATATTTAGGAAGCT 1441 TTTAAAAGACACTAAATTGTACTCTAAAAGACACTAAATTGTACTAATTGTACAAAGGTCAAGCCAATTTTATGAAACAG 1521 TCCTACAGAGTAATATATGTGATGCAGTGTAAGAAGGAAAATACTCATCTCTAACATTATGGTAATAACATTTAGCCTCT 1601 TAGGAGTTGGAGCAGGGGGATGGGTAATTACAGATTTGCAGACTATAGAAAGAGTTTCATTTTTTTGTGACCCCACAGAG 1681 TCTCAAATTTTTATTTCACTACCTGCTAGAGCCTACTGTGAAATCACTGCTCCATATTTGCCAGTGGAGGAAATGGGCAT 1761 AGAGTAGAGAATAGCTTCATATGTTTACACGTTTGCATAGACTACACACATGTCATGCGTTTATGGCAGGTAGCTGGTAT 1841 TTATTCCCCAAAGTAATAATGTTGAAGTATGGGTCTCATCATTCCCATACACAGAAACACAAAACACTTTGATCATAAAC 1921 TTTTTTCTTCAGAAGCCAAACTAACTTGCAGAATAATAGAGCCACTGGTTTAATGTTTCCTCAAGATAGGTTTTAGTGTA 2001 AGCTAGTATTCTGTGTGTTCGTAGAAATGATTCAATACCTGCAGCTGGTGAATTAGGAATTGTATTTGTTGCCTTTTTTA 2081 TATTAGATGAGGTGCAAAAATTTTAATGCTAGTCAGTATGCACCACCACAGGAAAGTTAGATCCCATTAGCACTTGAAAC 2161 TACAGCTTTGGAAACTTAGGCTAAGTTAATTTGGATTTGTTACTTGATTCACCTACTGACCTTTTCTTTTGTTTGAAGTG 2241 CTTATCAGCATAATGAGCTAAGTGTCATGCATATTTGTGAAGAAACACCCTTTTTGGTCCCTTTTGGGACAGAGAGGTAC 2321 TCCTTGATCTTTATGAATGACAGGTTACTGTTTTGCCTTATTGCTTAACTTAATGTAGTGAAATAAAGCAGACAAAGCTT 2401 GAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 51164.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM545217 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-7 transfection |
Location of target site | ENST00000447998.2 | 3UTR | UCAAAUAAGACCAUUUUGAUUGUAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1065670 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000447998.2 | 3UTR | UCAAAUAAGACCAUUUUGAUUGUAAAC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT085323 | MORC3 | MORC family CW-type zinc finger 3 | ![]() |
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2 | 2 | ||||||
MIRT089441 | STAMBP | STAM binding protein | ![]() |
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2 | 2 | ||||||
MIRT089456 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT111856 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT184933 | ZNF268 | zinc finger protein 268 | ![]() |
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2 | 2 | ||||||
MIRT215288 | CREBRF | CREB3 regulatory factor | ![]() |
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2 | 2 | ||||||
MIRT237300 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
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2 | 2 | ||||||
MIRT238446 | MYO10 | myosin X | ![]() |
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2 | 4 | ||||||
MIRT273827 | RPL41 | ribosomal protein L41 | ![]() |
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2 | 2 | ||||||
MIRT282703 | HOOK1 | hook microtubule tethering protein 1 | ![]() |
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2 | 2 | ||||||
MIRT347970 | ZNF850 | zinc finger protein 850 | ![]() |
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2 | 2 | ||||||
MIRT371076 | KLF3 | Kruppel like factor 3 | ![]() |
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2 | 2 | ||||||
MIRT464339 | USP6NL | USP6 N-terminal like | ![]() |
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2 | 2 | ||||||
MIRT470034 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT477506 | ELL2 | elongation factor for RNA polymerase II 2 | ![]() |
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2 | 2 | ||||||
MIRT482886 | CACNA2D3 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | ![]() |
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2 | 2 | ||||||
MIRT492606 | POLR3E | RNA polymerase III subunit E | ![]() |
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2 | 2 | ||||||
MIRT502294 | GNG12 | G protein subunit gamma 12 | ![]() |
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2 | 6 | ||||||
MIRT507600 | DCTN4 | dynactin subunit 4 | ![]() |
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2 | 4 | ||||||
MIRT510728 | SON | SON DNA binding protein | ![]() |
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2 | 6 | ||||||
MIRT514065 | KCNJ6 | potassium voltage-gated channel subfamily J member 6 | ![]() |
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2 | 8 | ||||||
MIRT519718 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 4 | ||||||
MIRT520890 | STRN | striatin | ![]() |
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2 | 2 | ||||||
MIRT521760 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 6 | ||||||
MIRT526874 | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | ![]() |
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2 | 2 | ||||||
MIRT530232 | WSB2 | WD repeat and SOCS box containing 2 | ![]() |
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2 | 2 | ||||||
MIRT532003 | ACTR2 | ARP2 actin related protein 2 homolog | ![]() |
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2 | 2 | ||||||
MIRT533371 | UBE2D4 | ubiquitin conjugating enzyme E2 D4 (putative) | ![]() |
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2 | 4 | ||||||
MIRT547106 | PIGW | phosphatidylinositol glycan anchor biosynthesis class W | ![]() |
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2 | 2 | ||||||
MIRT548189 | FOXA1 | forkhead box A1 | ![]() |
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2 | 2 | ||||||
MIRT552935 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT560085 | ZNF195 | zinc finger protein 195 | ![]() |
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2 | 2 | ||||||
MIRT561726 | PPP2CA | protein phosphatase 2 catalytic subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT562713 | ZNF415 | zinc finger protein 415 | ![]() |
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2 | 2 | ||||||
MIRT562761 | ZNF846 | zinc finger protein 846 | ![]() |
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2 | 2 | ||||||
MIRT564159 | ZNF117 | zinc finger protein 117 | ![]() |
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2 | 2 | ||||||
MIRT565673 | SETD5 | SET domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT565718 | SESN3 | sestrin 3 | ![]() |
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2 | 2 | ||||||
MIRT566026 | RFX1 | regulatory factor X1 | ![]() |
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2 | 2 | ||||||
MIRT569048 | ZNF655 | zinc finger protein 655 | ![]() |
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2 | 2 | ||||||
MIRT570367 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 2 | ||||||
MIRT570410 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT570443 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 2 | ||||||
MIRT571738 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT575042 | Tpgs2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 4 | ||||||
MIRT614330 | ZDHHC22 | zinc finger DHHC-type containing 22 | ![]() |
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2 | 2 | ||||||
MIRT617629 | RAB3IP | RAB3A interacting protein | ![]() |
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2 | 2 | ||||||
MIRT621667 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT639906 | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | ![]() |
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2 | 2 | ||||||
MIRT651436 | XRCC5 | X-ray repair cross complementing 5 | ![]() |
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2 | 2 | ||||||
MIRT683853 | ZNF208 | zinc finger protein 208 | ![]() |
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2 | 2 | ||||||
MIRT684841 | TPGS2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 5 | ||||||
MIRT689347 | ZNF83 | zinc finger protein 83 | ![]() |
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2 | 2 | ||||||
MIRT692492 | SPIN4 | spindlin family member 4 | ![]() |
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2 | 2 | ||||||
MIRT695711 | OLA1 | Obg like ATPase 1 | ![]() |
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2 | 2 | ||||||
MIRT698219 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT711560 | FAM20B | FAM20B, glycosaminoglycan xylosylkinase | ![]() |
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2 | 2 | ||||||
MIRT712867 | TMEM67 | transmembrane protein 67 | ![]() |
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2 | 2 | ||||||
MIRT722956 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT723622 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT724176 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 2 | ||||||
MIRT755363 | LMBR1 | limb development membrane protein 1 | 3 | 1 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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