pre-miRNA Information
pre-miRNA hsa-mir-367   
Genomic Coordinates chr4: 112647874 - 112647941
Synonyms MIRN367, hsa-mir-367, MIR367
Description Homo sapiens miR-367 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-367-3p
Sequence 44| AAUUGCACUUUAGCAAUGGUGA |65
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24411246 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs535597757 1 dbSNP
rs1013348949 11 dbSNP
rs896333735 12 dbSNP
rs751269136 14 dbSNP
rs1163501507 16 dbSNP
rs757092597 21 dbSNP
Putative Targets

Gene Information
Gene Symbol CNOT2   
Synonyms CDC36, HSPC131, NOT2, NOT2H
Description CCR4-NOT transcription complex subunit 2
Transcript NM_014515   
Expression
Putative miRNA Targets on CNOT2
3'UTR of CNOT2
(miRNA target sites are highlighted)
>CNOT2|NM_014515|3'UTR
   1 AAAAAAAAAAAAAAAAAAAAAAAGACTTCCCTTTTCTTGGGGTATGGCTGTCTCAGCACAATACTCAACATAACTGCAGA
  81 ACTGATGTGGCTCAGGCACCCTGGTTTTAATTCCTTGAGGATCTGGCAATTGGCTTACGCAAAAGGTCACCATTTGAGGT
 161 CCTGCCTTACTAATTATGTGCTGCCCAACAACTAAATTTGTAATTTGTTTTTCTCTAGTTTGAGCAGGGTCTGAATTTTT
 241 TCATTTATTTCCTTTTTTGCCAGCAGACAGACTTGAGTCTGTAAAGACAAGCAAATACACTGACAGAAGTTTACCATAGT
 321 TTCTAAAATGTAAAAAAGAAAACCCCCAAAAGACTCAAGAAAATTAGACCACAAATTTTGCATTGTTCATTGTAGCACTA
 401 TTGGTAATAAAATAACAAATGTTTGTGCATTTTTATGTGAAGATCCTTCTCGTATTTCATTTGGAAAGATGAGCAAGAGG
 481 TCTGCTTCCTTCATTTTACTTCCCCTTCTGTTTTTGAAAGGCAGTTTCGCCAAGCTTAATGCAAGAATATCTGACTGTTT
 561 AGAAGAAAGATATTGCCACAATCTCTGGATGGTTTTCCAGGGTTGTGTTATTACTGAGCTTCATCTTTCCAGAATGAGCA
 641 AAACACTGTCCAGTCTTTGTTACGATTTTGTAATAAATGTGTACATTTTTTTTAAATTTTTGGACATCACATGAATAAAG
 721 GTATGTATGTACGAATGTGTATATATTATATATATGACATCTATTTTGGAAAATGTTTGCCCTGCTGTACCTCATTTTTA
 801 GGAGGTGTGCATGGATGCAATATATGAAAATGGGACATTCTGGAACTGCTGGTCAGGGGACTTTGTCGCCCTGTGCACTA
 881 AAAGGGCCAGATTTTCAGCAGCCAAGGACATCCATACCCAAGTGAATGTGATGGGACTTAAAAGAAGTGAACTGAGACAA
 961 TTCACTCTGGCTGTTTGAACAGCAGCGTTTCATAGGAAGAGAAAAAAAGATCAATCTTGTATTTTCTGACCACATAAAGG
1041 CTTCTTCTCTTTGTAATAAAGTAGAAAAGCTCTCCTCAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agUGGUAACGAUUUCACGUUAa 5'
            || | ||:|   ||||| | 
Target 5' taACAAATGTT--TGTGCATTt 3'
413 - 432 120.00 -6.82
2
miRNA  3' agugguaacgauuucACGUUAa 5'
                         |||||| 
Target 5' ggaggtgtgcatggaTGCAATa 3'
801 - 822 120.00 -6.60
3
miRNA  3' agUGGU---AACGAUUUCACGUUaa 5'
            ||||   || ||||| ||:||  
Target 5' ttACCATAGTTTCTAAAATGTAAaa 3'
311 - 335 112.00 -9.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM1363986 24 COSMIC
COSM5957647 24 COSMIC
COSN505906 31 COSMIC
COSN31568581 35 COSMIC
COSN30455760 37 COSMIC
COSN30533726 43 COSMIC
COSN30161674 55 COSMIC
COSN13415992 68 COSMIC
COSN30148836 73 COSMIC
COSN13415993 82 COSMIC
COSN30158396 85 COSMIC
COSN13415994 113 COSMIC
COSN31605073 115 COSMIC
COSN31578360 116 COSMIC
COSN8121280 185 COSMIC
COSN31543190 187 COSMIC
COSN26576142 192 COSMIC
COSN30526802 192 COSMIC
COSN31490718 223 COSMIC
COSN31537019 317 COSMIC
COSN7379131 353 COSMIC
COSN7379132 469 COSMIC
COSN7379133 566 COSMIC
COSN7379134 570 COSMIC
COSN5858866 598 COSMIC
COSN31486999 617 COSMIC
COSN7379135 654 COSMIC
COSN30539437 671 COSMIC
COSN7379136 675 COSMIC
COSN30230306 694 COSMIC
COSN31578756 694 COSMIC
COSN7379137 703 COSMIC
COSN7379138 704 COSMIC
COSN7379139 714 COSMIC
COSN5718722 742 COSMIC
COSN7379140 827 COSMIC
COSN31597114 831 COSMIC
COSN7379141 835 COSMIC
COSN7379142 945 COSMIC
COSN31483336 968 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1226592628 1 dbSNP
rs767379877 3 dbSNP
rs1335354124 6 dbSNP
rs972182449 8 dbSNP
rs1244738855 9 dbSNP
rs1454860507 10 dbSNP
rs1488056276 10 dbSNP
rs761390170 13 dbSNP
rs920584610 13 dbSNP
rs1225745183 14 dbSNP
rs1252299811 14 dbSNP
rs1470196455 17 dbSNP
rs764795226 17 dbSNP
rs80086450 22 dbSNP
rs559712937 23 dbSNP
rs1344959195 24 dbSNP
rs772696861 24 dbSNP
rs75865097 25 dbSNP
rs1285805852 27 dbSNP
rs1463591331 31 dbSNP
rs764290127 32 dbSNP
rs762928593 37 dbSNP
rs992250193 37 dbSNP
rs577996590 43 dbSNP
rs950492686 47 dbSNP
rs1299118290 48 dbSNP
rs1352490778 51 dbSNP
rs1254651485 54 dbSNP
rs992668387 54 dbSNP
rs1232937833 55 dbSNP
rs1435173044 61 dbSNP
rs1311287805 62 dbSNP
rs142384304 69 dbSNP
rs1050621208 71 dbSNP
rs917162537 79 dbSNP
rs910834868 86 dbSNP
rs750586587 88 dbSNP
rs1221489828 91 dbSNP
rs1040479495 93 dbSNP
rs903357319 94 dbSNP
rs999000218 100 dbSNP
rs1341909122 102 dbSNP
rs1054249292 103 dbSNP
rs892774796 105 dbSNP
rs1373916714 106 dbSNP
rs76342799 114 dbSNP
rs1172803616 122 dbSNP
rs1447818574 130 dbSNP
rs564432540 131 dbSNP
rs1308109820 133 dbSNP
rs1220885933 135 dbSNP
rs184710031 139 dbSNP
rs1022649449 140 dbSNP
rs912982995 142 dbSNP
rs971279992 143 dbSNP
rs543868986 150 dbSNP
rs1194257455 162 dbSNP
rs1002794153 167 dbSNP
rs780145489 168 dbSNP
rs1015810109 170 dbSNP
rs945543043 175 dbSNP
rs961268786 184 dbSNP
rs1051921822 188 dbSNP
rs890690895 191 dbSNP
rs562157201 195 dbSNP
rs1395312604 196 dbSNP
rs1396954652 198 dbSNP
rs769702630 207 dbSNP
rs1428086324 216 dbSNP
rs920717007 217 dbSNP
rs1389735734 222 dbSNP
rs1170055377 227 dbSNP
rs374594056 230 dbSNP
rs1039707565 236 dbSNP
rs1187454107 238 dbSNP
rs1419754343 251 dbSNP
rs1404449789 253 dbSNP
rs1420131835 261 dbSNP
rs1253133640 262 dbSNP
rs547560128 262 dbSNP
rs751618057 265 dbSNP
rs910573131 274 dbSNP
rs566075898 277 dbSNP
rs1026364643 280 dbSNP
rs1040662032 291 dbSNP
rs371789603 296 dbSNP
rs934866900 300 dbSNP
rs1243996257 306 dbSNP
rs747030628 317 dbSNP
rs1024168246 319 dbSNP
rs878948991 324 dbSNP
rs1272328438 330 dbSNP
rs1303968522 334 dbSNP
rs1407217868 334 dbSNP
rs1012688888 351 dbSNP
rs1388671224 354 dbSNP
rs1162690892 357 dbSNP
rs969947687 359 dbSNP
rs1366027144 373 dbSNP
rs1340288638 377 dbSNP
rs1044045454 378 dbSNP
rs550967701 390 dbSNP
rs1228016589 393 dbSNP
rs151174526 394 dbSNP
rs980012329 395 dbSNP
rs906876874 396 dbSNP
rs1250707043 397 dbSNP
rs1002784027 401 dbSNP
rs1452918597 404 dbSNP
rs1287156413 405 dbSNP
rs1208682418 417 dbSNP
rs1323586785 426 dbSNP
rs1269915451 427 dbSNP
rs376070052 430 dbSNP
rs1226410045 438 dbSNP
rs957020333 444 dbSNP
rs1438891906 445 dbSNP
rs536764390 452 dbSNP
rs1214185365 466 dbSNP
rs189988942 474 dbSNP
rs1267451017 499 dbSNP
rs961486936 501 dbSNP
rs995383963 507 dbSNP
rs912981886 515 dbSNP
rs17108044 529 dbSNP
rs764196432 530 dbSNP
rs17108045 535 dbSNP
rs943558891 543 dbSNP
rs1478822868 549 dbSNP
rs913589883 555 dbSNP
rs553193972 557 dbSNP
rs182181862 558 dbSNP
rs1447065860 561 dbSNP
rs1249893623 574 dbSNP
rs1206746828 577 dbSNP
rs769672315 578 dbSNP
rs545275804 581 dbSNP
rs1461532793 585 dbSNP
rs930652202 589 dbSNP
rs186055379 590 dbSNP
rs1343198571 593 dbSNP
rs1274473299 602 dbSNP
rs1166237732 603 dbSNP
rs576349293 606 dbSNP
rs1388504544 627 dbSNP
rs966053328 632 dbSNP
rs540258673 635 dbSNP
rs796864299 639 dbSNP
rs1318561367 640 dbSNP
rs61929939 647 dbSNP
rs573801074 656 dbSNP
rs924917470 659 dbSNP
rs1435043949 662 dbSNP
rs934921498 664 dbSNP
rs1014375223 665 dbSNP
rs1413096803 672 dbSNP
rs1422688287 676 dbSNP
rs77308165 679 dbSNP
rs1447489175 682 dbSNP
rs12812983 684 dbSNP
rs12813152 685 dbSNP
rs759302118 685 dbSNP
rs1391495068 686 dbSNP
rs905669955 686 dbSNP
rs1186065406 688 dbSNP
rs914745708 694 dbSNP
rs1032923314 695 dbSNP
rs1234009587 697 dbSNP
rs1287867469 698 dbSNP
rs1212045038 706 dbSNP
rs1440479151 707 dbSNP
rs12813311 711 dbSNP
rs1277575119 724 dbSNP
rs1326979165 729 dbSNP
rs1206897784 733 dbSNP
rs948418186 734 dbSNP
rs1284616950 748 dbSNP
rs988479392 773 dbSNP
rs1384244346 774 dbSNP
rs1441649228 774 dbSNP
rs1019939975 775 dbSNP
rs955055519 780 dbSNP
rs1329894380 781 dbSNP
rs12813359 792 dbSNP
rs1207530484 811 dbSNP
rs556306869 821 dbSNP
rs986490395 826 dbSNP
rs1044202967 832 dbSNP
rs12813525 837 dbSNP
rs576297765 838 dbSNP
rs938352666 839 dbSNP
rs975349990 841 dbSNP
rs1180794229 844 dbSNP
rs1183534550 846 dbSNP
rs1471739082 847 dbSNP
rs1236707448 848 dbSNP
rs1037345874 852 dbSNP
rs1409199827 853 dbSNP
rs1471891758 857 dbSNP
rs897044171 859 dbSNP
rs995849230 860 dbSNP
rs930914704 863 dbSNP
rs189596966 868 dbSNP
rs181845820 869 dbSNP
rs370244879 872 dbSNP
rs1227118948 873 dbSNP
rs185381522 881 dbSNP
rs950047643 887 dbSNP
rs559475982 891 dbSNP
rs1017664485 904 dbSNP
rs35656103 906 dbSNP
rs61929940 910 dbSNP
rs905953047 913 dbSNP
rs1307497550 932 dbSNP
rs1428633641 941 dbSNP
rs770519532 959 dbSNP
rs774092924 961 dbSNP
rs1349979035 962 dbSNP
rs551625059 963 dbSNP
rs758945998 976 dbSNP
rs767081672 986 dbSNP
rs1241030650 987 dbSNP
rs754277703 988 dbSNP
rs1343985156 994 dbSNP
rs1249968659 995 dbSNP
rs1181730242 996 dbSNP
rs367816231 999 dbSNP
rs914737405 1000 dbSNP
rs893042889 1001 dbSNP
rs1219411431 1002 dbSNP
rs1282260099 1002 dbSNP
rs1269308174 1004 dbSNP
rs1010542278 1010 dbSNP
rs762323937 1013 dbSNP
rs979830275 1015 dbSNP
rs1020176970 1022 dbSNP
rs928399801 1029 dbSNP
rs1204080486 1034 dbSNP
rs938445307 1035 dbSNP
rs780544750 1041 dbSNP
rs1159800561 1042 dbSNP
rs1036678418 1045 dbSNP
rs1458684222 1047 dbSNP
rs1409503711 1050 dbSNP
rs765538755 1066 dbSNP
rs1434012886 1071 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agugguaacgauuUCACGUUAa 5'
                       |||||||| 
Target 5' ------------cAGUGCAAUa 3'
1 - 10
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 4848.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agugguaacgauuUCACGUUAa 5'
                       |||||||| 
Target 5' ------------cAGUGCAAUa 3'
1 - 10
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 4848.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 4848.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000229195.3 | 3UTR | CAGUGCAAUAUUAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000229195.3 | 3UTR | CAGUGCAAUAUUAAAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000229195.3 | 3UTR | CAGUGCAAUAUUAAAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000229195.3 | 3UTR | CAGUGCAAUAUUAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis 0.411 3.2e-2 0.292 1.0e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.417 3.4e-2 -0.600 2.6e-3 20 Click to see details
GSE28544 Breast cancer 0.321 6.3e-2 0.494 7.1e-3 24 Click to see details
GSE32688 Pancreatic cancer -0.236 9.7e-2 -0.240 9.3e-2 32 Click to see details
GSE21687 Ependynoma primary tumors 0.158 1.1e-1 -0.116 1.8e-1 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.27 1.1e-1 -0.236 1.4e-1 23 Click to see details
GSE19350 CNS germ cell tumors 0.361 1.2e-1 0.308 1.7e-1 12 Click to see details
GSE27834 Pluripotent stem cells 0.304 1.3e-1 0.174 2.6e-1 16 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.4 2.5e-1 0.300 3.1e-1 5 Click to see details
GSE28260 Renal cortex and medulla 0.185 2.7e-1 0.141 3.2e-1 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.098 3.2e-1 -0.397 2.5e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.073 3.7e-1 -0.059 3.9e-1 24 Click to see details
GSE17306 Multiple myeloma -0.041 3.9e-1 0.433 9.4e-4 49 Click to see details
GSE17498 Multiple myeloma 0.042 4.0e-1 0.062 3.5e-1 40 Click to see details
GSE14794 Lymphoblastoid cells 0.009 4.7e-1 0.031 3.9e-1 90 Click to see details
GSE21849 B cell lymphoma -0.012 4.8e-1 0.075 3.5e-1 29 Click to see details
GSE21849 B cell lymphoma -0.012 4.8e-1 0.075 3.5e-1 29 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
255 hsa-miR-367-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055315 DUSP5 dual specificity phosphatase 5 2 8
MIRT055791 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT057114 DDIT4 DNA damage inducible transcript 4 2 4
MIRT059663 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT059926 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT061610 BTG2 BTG anti-proliferation factor 2 2 6
MIRT066478 HMGA2 high mobility group AT-hook 2 2 2
MIRT069388 ZFYVE21 zinc finger FYVE-type containing 21 2 2
MIRT069972 GEMIN2 gem nuclear organelle associated protein 2 2 2
MIRT074764 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT076199 GID4 GID complex subunit 4 homolog 2 6
MIRT077512 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT077903 TOB1 transducer of ERBB2, 1 2 6
MIRT082250 MED29 mediator complex subunit 29 2 4
MIRT082434 CIC capicua transcriptional repressor 2 6
MIRT082474 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT082778 ZNF264 zinc finger protein 264 2 2
MIRT084533 BCL2L11 BCL2 like 11 2 8
MIRT085309 UBXN4 UBX domain protein 4 2 8
MIRT086365 SSFA2 sperm specific antigen 2 2 8
MIRT087455 NF2 neurofibromin 2 2 2
MIRT088865 FOXN2 forkhead box N2 2 12
MIRT092185 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 2 6
MIRT092326 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 6
MIRT093533 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096935 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT097026 MAP1B microtubule associated protein 1B 2 4
MIRT099137 MYLIP myosin regulatory light chain interacting protein 2 6
MIRT099905 SOX4 SRY-box 4 2 12
MIRT102289 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102507 KLHDC10 kelch domain containing 10 2 2
MIRT102891 INSIG1 insulin induced gene 1 2 2
MIRT109188 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT124567 PRRC2B proline rich coiled-coil 2B 2 2
MIRT135568 SPRYD4 SPRY domain containing 4 2 2
MIRT161135 SLC25A36 solute carrier family 25 member 36 2 6
MIRT163995 KIAA1109 KIAA1109 2 4
MIRT164689 RNF4 ring finger protein 4 2 2
MIRT167705 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2 8
MIRT178956 USP28 ubiquitin specific peptidase 28 2 2
MIRT185717 ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 2 2
MIRT186264 TCEB3 elongin A 2 2
MIRT186537 TWF1 twinfilin actin binding protein 1 2 4
MIRT186628 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT189373 TXLNA taxilin alpha 2 4
MIRT197013 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT206437 YIPF4 Yip1 domain family member 4 2 2
MIRT211228 FGF2 fibroblast growth factor 2 2 10
MIRT214529 C5ORF24 chromosome 5 open reading frame 24 2 2
MIRT216034 IL6ST interleukin 6 signal transducer 2 10
MIRT218084 TULP4 tubby like protein 4 2 2
MIRT242418 CCDC113 coiled-coil domain containing 113 2 2
MIRT243162 SOX11 SRY-box 11 2 2
MIRT250943 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT253350 ZNF417 zinc finger protein 417 2 2
MIRT271968 ARF1 ADP ribosylation factor 1 2 2
MIRT273214 ZNF695 zinc finger protein 695 2 4
MIRT296114 SLC12A5 solute carrier family 12 member 5 2 2
MIRT301711 TEF TEF, PAR bZIP transcription factor 2 2
MIRT316477 ARID1B AT-rich interaction domain 1B 2 6
MIRT322174 CLN8 CLN8, transmembrane ER and ERGIC protein 2 4
MIRT341538 CNIH1 cornichon family AMPA receptor auxiliary protein 1 2 6
MIRT356062 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT443579 PPIC peptidylprolyl isomerase C 2 2
MIRT448825 FKBP1A FK506 binding protein 1A 2 4
MIRT451494 FOPNL FGFR1OP N-terminal like 2 2
MIRT452694 MDM2 MDM2 proto-oncogene 2 2
MIRT453167 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT454588 SLC33A1 solute carrier family 33 member 1 2 4
MIRT455794 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT456010 CYP2C19 cytochrome P450 family 2 subfamily C member 19 2 2
MIRT456044 KIAA1586 KIAA1586 2 2
MIRT456763 TMEM239 transmembrane protein 239 2 4
MIRT458068 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT459230 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT459534 MFF mitochondrial fission factor 2 6
MIRT459759 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT460236 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT461104 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT462924 ZNRF3 zinc and ring finger 3 2 2
MIRT463476 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463516 ZBTB8B zinc finger and BTB domain containing 8B 2 4
MIRT465503 TOR1B torsin family 1 member B 2 2
MIRT469525 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT470079 PTGES2 prostaglandin E synthase 2 2 2
MIRT471581 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT473451 MCOLN2 mucolipin 2 2 8
MIRT475882 H3F3C H3 histone family member 3C 2 10
MIRT475915 H3F3B H3 histone family member 3B 2 8
MIRT476195 GOLGA8A golgin A8 family member A 2 10
MIRT476318 GM2A GM2 ganglioside activator 2 2
MIRT476676 FUT11 fucosyltransferase 11 2 10
MIRT478368 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479545 CDC5L cell division cycle 5 like 2 2
MIRT481024 BAZ2B bromodomain adjacent to zinc finger domain 2B 2 2
MIRT491009 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT493168 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT494345 CASKIN1 CASK interacting protein 1 2 2
MIRT499087 ZDHHC21 zinc finger DHHC-type containing 21 2 6
MIRT500029 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501298 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 4
MIRT503124 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT503301 GTF2A1 general transcription factor IIA subunit 1 2 6
MIRT504328 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504471 EID2B EP300 interacting inhibitor of differentiation 2B 2 2
MIRT504655 RPL9 ribosomal protein L9 2 6
MIRT505331 TMF1 TATA element modulatory factor 1 2 8
MIRT505732 SERTAD3 SERTA domain containing 3 2 4
MIRT505827 RSBN1 round spermatid basic protein 1 2 8
MIRT506004 PURG purine rich element binding protein G 2 8
MIRT506308 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT506806 KLHL15 kelch like family member 15 2 6
MIRT507119 GOLGA8B golgin A8 family member B 2 6
MIRT507353 FAM129A family with sequence similarity 129 member A 2 6
MIRT507591 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT507674 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 4
MIRT507703 CNOT2 CCR4-NOT transcription complex subunit 2 2 8
MIRT508012 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510439 ZIC5 Zic family member 5 2 6
MIRT510539 XKR7 XK related 7 2 4
MIRT510600 TPPP tubulin polymerization promoting protein 2 6
MIRT511060 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT511855 GOLGA8J golgin A8 family member J 2 6
MIRT511865 GOLGA8I golgin A8 family member I, pseudogene 1 3
MIRT512570 CTDSPL CTD small phosphatase like 2 2
MIRT512708 ZNF134 zinc finger protein 134 2 6
MIRT513177 MOAP1 modulator of apoptosis 1 2 6
MIRT513783 PAWR pro-apoptotic WT1 regulator 2 6
MIRT515099 IRGQ immunity related GTPase Q 2 2
MIRT515481 INCENP inner centromere protein 2 4
MIRT517416 BMP8A bone morphogenetic protein 8a 2 2
MIRT518754 C1orf35 chromosome 1 open reading frame 35 2 2
MIRT519780 ZNF354B zinc finger protein 354B 2 4
MIRT519865 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520510 TRAM2 translocation associated membrane protein 2 2 6
MIRT521068 SLC25A32 solute carrier family 25 member 32 2 6
MIRT526912 ZNF772 zinc finger protein 772 2 6
MIRT527134 GULP1 GULP, engulfment adaptor PTB domain containing 1 2 2
MIRT527867 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528404 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT532956 ZNF24 zinc finger protein 24 2 4
MIRT533021 ZFC3H1 zinc finger C3H1-type containing 2 4
MIRT533191 WASL Wiskott-Aldrich syndrome like 2 6
MIRT534191 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534961 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT536396 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT537046 GRAMD4 GRAM domain containing 4 2 2
MIRT537125 GOLGA3 golgin A3 2 4
MIRT537183 GFPT2 glutamine-fructose-6-phosphate transaminase 2 2 4
MIRT537652 ERGIC2 ERGIC and golgi 2 2 4
MIRT538632 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539231 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT540099 NPY4R neuropeptide Y receptor Y4 2 2
MIRT540998 ZNF460 zinc finger protein 460 2 4
MIRT541468 AURKA aurora kinase A 2 2
MIRT542680 SESN3 sestrin 3 2 2
MIRT542757 PRRG4 proline rich and Gla domain 4 2 2
MIRT542863 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT542925 HOXC8 homeobox C8 2 2
MIRT543747 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT544404 ZSCAN12 zinc finger and SCAN domain containing 12 2 2
MIRT544583 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544662 MED19 mediator complex subunit 19 2 2
MIRT545251 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT545261 TRIM36 tripartite motif containing 36 2 4
MIRT545744 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT545999 WDR81 WD repeat domain 81 2 2
MIRT546038 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT547170 PDZD8 PDZ domain containing 8 2 2
MIRT547273 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT547729 KIF5B kinesin family member 5B 2 2
MIRT548127 GATA6 GATA binding protein 6 2 2
MIRT548203 FNIP1 folliculin interacting protein 1 2 2
MIRT548756 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 2
MIRT549641 ZNF75A zinc finger protein 75a 2 2
MIRT549684 ZNF598 zinc finger protein 598 2 2
MIRT550197 MRO maestro 2 2
MIRT550340 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT550536 MYZAP myocardial zonula adherens protein 2 2
MIRT550975 TOR4A torsin family 4 member A 2 2
MIRT551221 CIDEC cell death inducing DFFA like effector c 2 2
MIRT551355 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT551571 LETM1 leucine zipper and EF-hand containing transmembrane protein 1 2 2
MIRT552277 RAB3D RAB3D, member RAS oncogene family 2 2
MIRT552661 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT553081 UCK2 uridine-cytidine kinase 2 2 2
MIRT553753 TBC1D8 TBC1 domain family member 8 2 2
MIRT554030 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554099 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT554155 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554815 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT555522 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555597 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT555632 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 4
MIRT555679 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT555827 PAX9 paired box 9 2 2
MIRT555868 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555939 NUP43 nucleoporin 43 2 2
MIRT555994 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556340 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556432 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556585 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT556801 KIAA1958 KIAA1958 2 2
MIRT558047 EXOC5 exocyst complex component 5 2 2
MIRT558697 CLTA clathrin light chain A 2 2
MIRT559191 BMPR1A bone morphogenetic protein receptor type 1A 2 4
MIRT559639 AKAP10 A-kinase anchoring protein 10 2 2
MIRT559707 AEN apoptosis enhancing nuclease 2 2
MIRT560673 SRFBP1 serum response factor binding protein 1 2 2
MIRT560990 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562170 HOXA13 homeobox A13 2 2
MIRT562275 GNAQ G protein subunit alpha q 2 2
MIRT563624 ZNF277 zinc finger protein 277 2 2
MIRT563815 FMN1 formin 1 2 2
MIRT564096 TLR3 toll like receptor 3 2 2
MIRT565320 TMEM41A transmembrane protein 41A 2 2
MIRT565986 RNF44 ring finger protein 44 2 2
MIRT566047 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT568236 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT568310 BAK1 BCL2 antagonist/killer 1 2 2
MIRT572376 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT574822 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT609212 PELP1 proline, glutamate and leucine rich protein 1 2 2
MIRT616217 RBM27 RNA binding motif protein 27 2 2
MIRT629087 FASLG Fas ligand 2 2
MIRT632124 FKBP9 FK506 binding protein 9 2 2
MIRT632576 POLQ DNA polymerase theta 2 2
MIRT634799 ENTHD1 ENTH domain containing 1 2 2
MIRT636553 ESRP1 epithelial splicing regulatory protein 1 2 2
MIRT640977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT653875 SH2B3 SH2B adaptor protein 3 2 2
MIRT655598 OTUD7B OTU deubiquitinase 7B 2 2
MIRT659764 CCDC171 coiled-coil domain containing 171 2 2
MIRT660744 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT681037 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682305 RBM28 RNA binding motif protein 28 2 2
MIRT682573 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT686217 ZNF267 zinc finger protein 267 2 2
MIRT687209 PLXNA3 plexin A3 2 2
MIRT690630 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT692419 AGMAT agmatinase 2 2
MIRT694437 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT700725 PNO1 partner of NOB1 homolog 2 2
MIRT701549 NARF nuclear prelamin A recognition factor 2 2
MIRT704379 DAND5 DAN domain BMP antagonist family member 5 2 2
MIRT707935 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT709939 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT711371 MED7 mediator complex subunit 7 2 2
MIRT712327 PER2 period circadian clock 2 2 2
MIRT714515 SHE Src homology 2 domain containing E 2 2
MIRT715520 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT724294 OSMR oncostatin M receptor 2 2
MIRT725358 MUC21 mucin 21, cell surface associated 2 2
MIRT732242 KLF4 Kruppel like factor 4 3 1
MIRT735384 SPAG5 sperm associated antigen 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-367 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-367 Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-367 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miR-367 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-367 Paclitaxel approved 36314 Microarray Ovarian cancer cell lines 24220856 2014 up-regulated
miR-367 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-367 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Siop Treatment Protocol sensitive High Nephroblastoma tissue
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved resistant High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-367-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (SKhep1, HA22T)
hsa-miR-367-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-367-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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