miRTarBase - #MIRT507809


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pre-miRNA Information
pre-miRNA hsa-mir-4463   
Genomic Coordinates chr6: 75428407 - 75428473
Description Homo sapiens miR-4463 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4463
Sequence 40| GAGACUGGGGUGGGGCC |56
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1176036098 3 dbSNP
rs368879370 7 dbSNP
rs991713068 9 dbSNP
rs909477315 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CDKN1B   
Synonyms CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Description cyclin dependent kinase inhibitor 1B
Transcript NM_004064   
Expression
Putative miRNA Targets on CDKN1B
3'UTR of CDKN1B
(miRNA target sites are highlighted)		 
>CDKN1B|NM_004064|3'UTR
   1 ACAGCTCGAATTAAGAATATGTTTCCTTGTTTATCAGATACATCACTGCTTGATGAAGCAAGGAAGATATACATGAAAAT
  81 TTTAAAAATACATATCGCTGACTTCATGGAATGGACATCCTGTATAAGCACTGAAAAACAACAACACAATAACACTAAAA
 161 TTTTAGGCACTCTTAAATGATCTGCCTCTAAAAGCGTTGGATGTAGCATTATGCAATTAGGTTTTTCCTTATTTGCTTCA
 241 TTGTACTACCTGTGTATATAGTTTTTACCTTTTATGTAGCACATAAACTTTGGGGAAGGGAGGGCAGGGTGGGGCTGAGG
 321 AACTGACGTGGAGCGGGGTATGAAGAGCTTGCTTTGATTTACAGCAAGTAGATAAATATTTGACTTGCATGAAGAGAAGC
 401 AATTTTGGGGAAGGGTTTGAATTGTTTTCTTTAAAGATGTAATGTCCCTTTCAGAGACAGCTGATACTTCATTTAAAAAA
 481 ATCACAAAAATTTGAACACTGGCTAAAGATAATTGCTATTTATTTTTACAAGAAGTTTATTCTCATTTGGGAGATCTGGT
 561 GATCTCCCAAGCTATCTAAAGTTTGTTAGATAGCTGCATGTGGCTTTTTTAAAAAAGCAACAGAAACCTATCCTCACTGC
 641 CCTCCCCAGTCTCTCTTAAAGTTGGAATTTACCAGTTAATTACTCAGCAGAATGGTGATCACTCCAGGTAGTTTGGGGCA
 721 AAAATCCGAGGTGCTTGGGAGTTTTGAATGTTAAGAATTGACCATCTGCTTTTATTAAATTTGTTGACAAAATTTTCTCA
 801 TTTTCTTTTCACTTCGGGCTGTGTAAACACAGTCAAAATAATTCTAAATCCCTCGATATTTTTAAAGATCTGTAAGTAAC
 881 TTCACATTAAAAAATGAAATATTTTTTAATTTAAAGCTTACTCTGTCCATTTATCCACAGGAAAGTGTTATTTTTCAAGG
 961 AAGGTTCATGTAGAGAAAAGCACACTTGTAGGATAAGTGAAATGGATACTACATCTTTAAACAGTATTTCATTGCCTGTG
1041 TATGGAAAAACCATTTGAAGTGTACCTGTGTACATAACTCTGTAAAAACACTGAAAAATTATACTAACTTATTTATGTTA
1121 AAAGATTTTTTTTAATCTAGACAATATACAAGCCAAAGTGGCATGTTTTGTGCATTTGTAAATGCTGTGTTGGGTAGAAT
1201 AGGTTTTCCCCTCTTTTGTTAAATAATATGGCTATGCTTAAAAGGTTGCATACTGAGCCAAGTATAATTTTTTGTAATGT
1281 GTGAAAAAGATGCCAATTATTGTTACACATTAAGTAATCAATAAAGAAAACTTCCATAGCTATTCATTGAGTCAAAAAAA
1361 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccgGGGUGGGGUCAGAg 5'
             ||| ||||||||| 
Target 5' ctgCCCTCCCCAGTCTc 3'
 637 - 653 162.00 -28.40
2 
miRNA  3' ccggggugggGUCAGag 5'
                    |||||  
Target 5' tgtgtaaacaCAGTCaa 3'
 820 - 836 100.00 -5.80
3 
miRNA  3' ccggGGUGGGGUCagag 5'
              :|||:||||    
Target 5' gtgaTCACTCCAGgtag 3'
 695 - 711 97.00 -12.96
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1038259 1 ClinVar
307671 2082 ClinVar
307672 2170 ClinVar
882254 2174 ClinVar
307673 2178 ClinVar
802820 2245 ClinVar
307674 2255 ClinVar
307675 2263 ClinVar
307676 2286 ClinVar
307677 2409 ClinVar
307678 2461 ClinVar
307679 2503 ClinVar
882515 2519 ClinVar
307680 2534 ClinVar
307681 2583 ClinVar
307682 2634 ClinVar
307683 2692 ClinVar
307684 2828 ClinVar
882516 2897 ClinVar
882517 2913 ClinVar
307685 2915 ClinVar
883303 2926 ClinVar
307686 3017 ClinVar
307687 3030 ClinVar
307688 3038 ClinVar
883304 3055 ClinVar
307689 3062 ClinVar
883305 3106 ClinVar
307690 3155 ClinVar
307691 3268 ClinVar
880944 3305 ClinVar
COSN30527689 10 COSMIC
COSN20071456 14 COSMIC
COSN13378837 28 COSMIC
COSN16626706 133 COSMIC
COSN21932257 215 COSMIC
COSN22780071 256 COSMIC
COSN20610862 439 COSMIC
COSN7610972 497 COSMIC
COSN5317787 688 COSMIC
COSN22880816 1010 COSMIC
COSN31882302 1433 COSMIC
COSN15846921 1598 COSMIC
COSN8700439 1713 COSMIC
COSN26555912 2111 COSMIC
COSN30144761 2115 COSMIC
COSN30477687 2145 COSMIC
COSN30508707 2152 COSMIC
COSN30141204 2162 COSMIC
COSN26957862 2178 COSMIC
COSN1562526 2187 COSMIC
COSN30550339 2198 COSMIC
COSN31503871 2231 COSMIC
COSN30491269 2246 COSMIC
COSN30464860 2248 COSMIC
COSN1144516 2256 COSMIC
COSN26970195 2281 COSMIC
COSN31595619 2284 COSMIC
COSN30464194 2309 COSMIC
COSN30104697 2312 COSMIC
COSN31556067 2326 COSMIC
COSN20047494 2390 COSMIC
COSN31588833 2401 COSMIC
COSN31541198 2476 COSMIC
COSN30121935 2508 COSMIC
COSN31577119 2538 COSMIC
COSN17181929 2646 COSMIC
COSN31520822 2690 COSMIC
COSN21427987 2911 COSMIC
COSN10100681 3134 COSMIC
COSN29775868 3184 COSMIC
COSN16586571 3188 COSMIC
COSN31607283 3204 COSMIC
COSN26641042 3293 COSMIC
COSN31481579 3295 COSMIC
COSN30165125 3296 COSMIC
rs3093733 606 GWAS
rs34327 1869 GWAS
rs4251697 2583 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1419927896 5 dbSNP
rs200321335 8 dbSNP
rs373715856 14 dbSNP
rs1459838767 15 dbSNP
rs967966312 17 dbSNP
rs758796091 20 dbSNP
rs1452424439 27 dbSNP
rs1365330019 28 dbSNP
rs1225020156 29 dbSNP
rs980425420 36 dbSNP
rs778347195 37 dbSNP
rs199735640 38 dbSNP
rs1371981393 39 dbSNP
rs755706185 43 dbSNP
rs368944124 44 dbSNP
rs372244831 45 dbSNP
rs1246875999 46 dbSNP
rs1315703642 47 dbSNP
rs1337812167 48 dbSNP
rs1434636823 50 dbSNP
rs992348337 62 dbSNP
rs917408577 63 dbSNP
rs930119475 65 dbSNP
rs1413202927 66 dbSNP
rs1213155357 70 dbSNP
rs1162797086 72 dbSNP
rs540763521 80 dbSNP
rs1442715614 84 dbSNP
rs1386789923 85 dbSNP
rs982923935 87 dbSNP
rs3093732 94 dbSNP
rs1485328653 95 dbSNP
rs910101148 99 dbSNP
rs893617706 101 dbSNP
rs374454092 104 dbSNP
rs1012049594 105 dbSNP
rs374131888 108 dbSNP
rs574732971 113 dbSNP
rs1362297438 116 dbSNP
rs1003665057 122 dbSNP
rs1393217388 124 dbSNP
rs1214396809 126 dbSNP
rs1026031750 127 dbSNP
rs1290810144 128 dbSNP
rs1431777902 129 dbSNP
rs1349313783 133 dbSNP
rs184721966 134 dbSNP
rs542173844 138 dbSNP
rs951362882 144 dbSNP
rs1387066394 146 dbSNP
rs1039703943 147 dbSNP
rs1436460326 148 dbSNP
rs754698120 149 dbSNP
rs1417159442 150 dbSNP
rs984348356 150 dbSNP
rs1187851244 151 dbSNP
rs1475542376 156 dbSNP
rs1267557448 157 dbSNP
rs1219687174 162 dbSNP
rs1490976544 165 dbSNP
rs188313143 168 dbSNP
rs192815744 169 dbSNP
rs1306076377 179 dbSNP
rs1298202778 181 dbSNP
rs1051639678 183 dbSNP
rs185372049 191 dbSNP
rs922832725 193 dbSNP
rs1406888890 196 dbSNP
rs141364268 198 dbSNP
rs1206093681 199 dbSNP
rs1461435125 202 dbSNP
rs987248657 205 dbSNP
rs923571514 206 dbSNP
rs1022140641 214 dbSNP
rs189195640 215 dbSNP
rs1376030928 217 dbSNP
rs181831737 220 dbSNP
rs903770346 223 dbSNP
rs1481111218 233 dbSNP
rs1269006672 234 dbSNP
rs1002565992 237 dbSNP
rs145208138 240 dbSNP
rs1303083033 241 dbSNP
rs529659755 242 dbSNP
rs935017125 243 dbSNP
rs1346353322 248 dbSNP
rs1479947067 251 dbSNP
rs960677443 255 dbSNP
rs1253443557 257 dbSNP
rs1205722405 266 dbSNP
rs1261452265 267 dbSNP
rs1225604597 271 dbSNP
rs1346164791 279 dbSNP
rs1053603751 284 dbSNP
rs1390742140 286 dbSNP
rs1013272342 291 dbSNP
rs893711012 292 dbSNP
rs548526479 295 dbSNP
rs1465985714 299 dbSNP
rs1025988189 301 dbSNP
rs1045292805 308 dbSNP
rs1173756169 318 dbSNP
rs950477418 322 dbSNP
rs982873097 326 dbSNP
rs1157819903 331 dbSNP
rs910091260 336 dbSNP
rs1253333297 339 dbSNP
rs776556616 362 dbSNP
rs962984225 362 dbSNP
rs1241696433 366 dbSNP
rs1461109865 366 dbSNP
rs976098878 383 dbSNP
rs906373686 384 dbSNP
rs368583151 392 dbSNP
rs921256786 406 dbSNP
rs1260202352 407 dbSNP
rs1237041370 415 dbSNP
rs1003996539 418 dbSNP
rs1237074545 421 dbSNP
rs1447456057 432 dbSNP
rs1381701962 436 dbSNP
rs933961155 441 dbSNP
rs1334452347 456 dbSNP
rs1281202005 460 dbSNP
rs1454243192 461 dbSNP
rs1402543792 470 dbSNP
rs1287751417 483 dbSNP
rs1450946171 489 dbSNP
rs527571123 493 dbSNP
rs746590934 494 dbSNP
rs552445491 513 dbSNP
rs1234796377 520 dbSNP
rs913948134 521 dbSNP
rs1025561028 523 dbSNP
rs570576132 533 dbSNP
rs1005541914 534 dbSNP
rs1185870330 537 dbSNP
rs1461922299 538 dbSNP
rs1261353903 539 dbSNP
rs1016967988 546 dbSNP
rs147646084 552 dbSNP
rs945482070 553 dbSNP
rs140861850 557 dbSNP
rs903716058 562 dbSNP
rs1002106899 564 dbSNP
rs997144139 572 dbSNP
rs796311643 575 dbSNP
rs896418863 580 dbSNP
rs1407679157 582 dbSNP
rs1172146133 585 dbSNP
rs1013638634 588 dbSNP
rs1354787268 592 dbSNP
rs955571264 592 dbSNP
rs3093733 605 dbSNP
rs72525724 605 dbSNP
rs1325671145 606 dbSNP
rs1424565333 606 dbSNP
rs1369225635 610 dbSNP
rs1443840006 611 dbSNP
rs1473309713 613 dbSNP
rs1275930457 616 dbSNP
rs1372895060 618 dbSNP
rs568382928 621 dbSNP
rs1242935944 622 dbSNP
rs987603913 624 dbSNP
rs1025940647 625 dbSNP
rs950469552 627 dbSNP
rs1221919264 634 dbSNP
rs1490159842 635 dbSNP
rs1308303497 636 dbSNP
rs1005962000 637 dbSNP
rs535483914 649 dbSNP
rs1269381970 650 dbSNP
rs989088403 653 dbSNP
rs184805329 663 dbSNP
rs1278248904 664 dbSNP
rs1271101099 678 dbSNP
rs1469643922 679 dbSNP
rs1343135170 683 dbSNP
rs1396144834 693 dbSNP
rs963228307 693 dbSNP
rs1166588191 695 dbSNP
rs1194225133 695 dbSNP
rs975625519 695 dbSNP
rs921481847 696 dbSNP
rs955652658 697 dbSNP
rs1479469394 699 dbSNP
rs188137396 703 dbSNP
rs1200829050 707 dbSNP
rs913936814 709 dbSNP
rs945429578 712 dbSNP
rs1193903668 719 dbSNP
rs1043855798 720 dbSNP
rs925375133 721 dbSNP
rs1474711846 722 dbSNP
rs1284652582 738 dbSNP
rs1437803578 743 dbSNP
rs545680350 745 dbSNP
rs1054976944 746 dbSNP
rs896356262 747 dbSNP
rs1175897668 754 dbSNP
rs3093734 756 dbSNP
rs1431534413 759 dbSNP
rs1005676343 761 dbSNP
rs1478301190 764 dbSNP
rs1463324490 766 dbSNP
rs1324566806 774 dbSNP
rs1038369027 784 dbSNP
rs899841373 800 dbSNP
rs1047379907 807 dbSNP
rs558071459 808 dbSNP
rs1029934665 809 dbSNP
rs1264446377 823 dbSNP
rs1219358426 827 dbSNP
rs1341192616 831 dbSNP
rs1278254517 837 dbSNP
rs1232975386 838 dbSNP
rs1291636038 839 dbSNP
rs181045998 845 dbSNP
rs1336559908 851 dbSNP
rs1214118627 853 dbSNP
rs1408634405 860 dbSNP
rs375589257 861 dbSNP
rs186188049 867 dbSNP
rs900262788 874 dbSNP
rs1400146955 877 dbSNP
rs1405917899 884 dbSNP
rs997384143 895 dbSNP
rs1156688427 896 dbSNP
rs1445226247 904 dbSNP
rs1217847064 906 dbSNP
rs1380683221 908 dbSNP
rs1182822059 914 dbSNP
rs999020683 915 dbSNP
rs1238885288 916 dbSNP
rs562578019 916 dbSNP
rs1210425670 930 dbSNP
rs1242263368 931 dbSNP
rs1445859822 936 dbSNP
rs1219425091 948 dbSNP
rs1355116332 949 dbSNP
rs1485043269 953 dbSNP
rs1028529863 959 dbSNP
rs574429572 960 dbSNP
rs1419605407 968 dbSNP
rs1284947849 973 dbSNP
rs565232753 974 dbSNP
rs191432313 976 dbSNP
rs1343445494 979 dbSNP
rs1475309087 982 dbSNP
rs528500598 982 dbSNP
rs1421431646 985 dbSNP
rs989197908 986 dbSNP
rs1164201908 989 dbSNP
rs914870366 1003 dbSNP
rs969098233 1004 dbSNP
rs1182013597 1013 dbSNP
rs1474916551 1015 dbSNP
rs981067039 1021 dbSNP
rs150088648 1022 dbSNP
rs1361294242 1023 dbSNP
rs1291636671 1026 dbSNP
rs2277396 1032 dbSNP
rs1323824532 1046 dbSNP
rs777690784 1053 dbSNP
rs939287978 1054 dbSNP
rs1360212251 1055 dbSNP
rs966675854 1061 dbSNP
rs181530489 1075 dbSNP
rs1400735552 1077 dbSNP
rs1345002735 1078 dbSNP
rs758528800 1079 dbSNP
rs908407434 1080 dbSNP
rs1245723675 1084 dbSNP
rs1351400225 1091 dbSNP
rs941393442 1093 dbSNP
rs1038469669 1098 dbSNP
rs899809797 1100 dbSNP
rs938114561 1106 dbSNP
rs932683744 1107 dbSNP
rs565083064 1120 dbSNP
rs369430578 1121 dbSNP
rs1286626968 1135 dbSNP
rs917794000 1136 dbSNP
rs148821642 1138 dbSNP
rs999102148 1139 dbSNP
rs1219504495 1140 dbSNP
rs1258920585 1144 dbSNP
rs1322841540 1148 dbSNP
rs186147324 1149 dbSNP
rs1384994009 1150 dbSNP
rs1369699384 1153 dbSNP
rs1293864175 1155 dbSNP
rs1047662123 1160 dbSNP
rs1180626172 1162 dbSNP
rs886376723 1163 dbSNP
rs1172297153 1164 dbSNP
rs1465825034 1169 dbSNP
rs1468894331 1170 dbSNP
rs941672102 1176 dbSNP
rs1381498667 1180 dbSNP
rs1037331961 1184 dbSNP
rs1268715697 1196 dbSNP
rs549688105 1207 dbSNP
rs1022056476 1210 dbSNP
rs577221023 1212 dbSNP
rs995973095 1215 dbSNP
rs530916972 1222 dbSNP
rs4251694 1228 dbSNP
rs1008416550 1229 dbSNP
rs1328398945 1233 dbSNP
rs868641182 1239 dbSNP
rs980443368 1241 dbSNP
rs1235563420 1242 dbSNP
rs1261312464 1242 dbSNP
rs1444144933 1244 dbSNP
rs1021186885 1245 dbSNP
rs3093735 1245 dbSNP
rs397751609 1245 dbSNP
rs1374293076 1246 dbSNP
rs57118552 1246 dbSNP
rs1333201876 1260 dbSNP
rs1447048864 1281 dbSNP
rs960646525 1311 dbSNP
rs982701241 1318 dbSNP
rs1467096405 1326 dbSNP
rs908338597 1329 dbSNP
rs1309666749 1331 dbSNP
rs1347069380 1335 dbSNP
rs966957652 1339 dbSNP
rs565690812 1340 dbSNP
rs1281913030 1341 dbSNP
rs941193781 1352 dbSNP
rs1345100989 1353 dbSNP
rs34329 1354 dbSNP
rs1260221667 1366 dbSNP
rs1214975197 1372 dbSNP
rs1311158936 1396 dbSNP
rs921348037 1404 dbSNP
rs1032385927 1407 dbSNP
rs558397242 1409 dbSNP
rs1240657041 1410 dbSNP
rs3093736 1422 dbSNP
rs1310076110 1426 dbSNP
rs1397433569 1428 dbSNP
rs1402214543 1431 dbSNP
rs1418384380 1434 dbSNP
rs917726057 1435 dbSNP
rs201576347 1441 dbSNP
rs1439143260 1464 dbSNP
rs1184462257 1467 dbSNP
rs1444336706 1473 dbSNP
rs949199745 1478 dbSNP
rs891156448 1483 dbSNP
rs1424681263 1484 dbSNP
rs1239098374 1486 dbSNP
rs1454269255 1487 dbSNP
rs1487252857 1500 dbSNP
rs1217278163 1513 dbSNP
rs983261511 1513 dbSNP
rs907763996 1515 dbSNP
rs1263463234 1516 dbSNP
rs1246529557 1517 dbSNP
rs770422414 1519 dbSNP
rs1053317714 1529 dbSNP
rs773915175 1532 dbSNP
rs921644527 1537 dbSNP
rs537681881 1538 dbSNP
rs1341858859 1545 dbSNP
rs544011856 1547 dbSNP
rs931705353 1551 dbSNP
rs1299279073 1554 dbSNP
rs1424585963 1555 dbSNP
rs1051498501 1556 dbSNP
rs1394648927 1562 dbSNP
rs1011686688 1563 dbSNP
rs145381362 1574 dbSNP
rs1331803074 1575 dbSNP
rs1478816088 1580 dbSNP
rs1264014699 1585 dbSNP
rs28536651 1596 dbSNP
rs1002395512 1598 dbSNP
rs1264973817 1598 dbSNP
rs541897036 1599 dbSNP
rs1305490425 1607 dbSNP
rs1331228719 1608 dbSNP
rs1216421692 1625 dbSNP
rs137924144 1625 dbSNP
rs1226085221 1627 dbSNP
rs183364864 1637 dbSNP
rs1278348279 1641 dbSNP
rs1404859931 1643 dbSNP
rs1034656194 1650 dbSNP
rs1341041370 1651 dbSNP
rs1387672901 1654 dbSNP
rs1396260990 1655 dbSNP
rs1198871749 1663 dbSNP
rs1467384497 1666 dbSNP
rs546139286 1667 dbSNP
rs1468294960 1682 dbSNP
rs188061168 1689 dbSNP
rs1032746164 1704 dbSNP
rs959425657 1705 dbSNP
rs962650276 1709 dbSNP
rs1434223369 1712 dbSNP
rs1174154692 1727 dbSNP
rs973883940 1732 dbSNP
rs1371351593 1737 dbSNP
rs1237341073 1743 dbSNP
rs1476544871 1752 dbSNP
rs1491199529 1753 dbSNP
rs1491559564 1754 dbSNP
rs1012680133 1757 dbSNP
rs774657993 1758 dbSNP
rs1171642806 1759 dbSNP
rs921136582 1761 dbSNP
rs1393503473 1765 dbSNP
rs932745695 1766 dbSNP
rs1411834102 1767 dbSNP
rs1025030541 1768 dbSNP
rs1335478136 1772 dbSNP
rs34328 1774 dbSNP
rs112256497 1777 dbSNP
rs1336356228 1780 dbSNP
rs907747627 1784 dbSNP
rs934673877 1786 dbSNP
rs1391402257 1788 dbSNP
rs561730023 1789 dbSNP
rs1174178565 1794 dbSNP
rs973366427 1797 dbSNP
rs921861796 1800 dbSNP
rs529349647 1801 dbSNP
rs1238368645 1805 dbSNP
rs1209020114 1812 dbSNP
rs1440142594 1813 dbSNP
rs931636166 1813 dbSNP
rs767087428 1818 dbSNP
rs914806809 1819 dbSNP
rs1292271792 1824 dbSNP
rs190633082 1825 dbSNP
rs1307505232 1829 dbSNP
rs1242715805 1831 dbSNP
rs539356675 1837 dbSNP
rs1314560246 1847 dbSNP
rs1044559894 1851 dbSNP
rs1342333457 1853 dbSNP
rs1334996555 1854 dbSNP
rs1414946251 1857 dbSNP
rs906032413 1868 dbSNP
rs34327 1869 dbSNP
rs945820455 1878 dbSNP
rs1042573711 1904 dbSNP
rs902714057 1913 dbSNP
rs1001508784 1914 dbSNP
rs1180852894 1917 dbSNP
rs1056636499 1919 dbSNP
rs755926085 1919 dbSNP
rs1238689544 1923 dbSNP
rs1489292229 1928 dbSNP
rs1194711997 1929 dbSNP
rs896127043 1931 dbSNP
rs1219448531 1933 dbSNP
rs764002012 1942 dbSNP
rs753818936 1944 dbSNP
rs758437103 1961 dbSNP
rs1381677276 1967 dbSNP
rs1015294906 1974 dbSNP
rs1430059749 1975 dbSNP
rs895401982 1980 dbSNP
rs1338553289 1983 dbSNP
rs1296209266 1990 dbSNP
rs1012215386 1995 dbSNP
rs1474326339 1996 dbSNP
rs1025398791 1998 dbSNP
rs533129842 2006 dbSNP
rs1004952124 2009 dbSNP
rs398098000 2012 dbSNP
rs75774823 2012 dbSNP
rs1415563533 2019 dbSNP
rs76967889 2027 dbSNP
rs1477175936 2030 dbSNP
rs963157332 2041 dbSNP
rs772002476 2042 dbSNP
rs4251695 2053 dbSNP
rs921836259 2055 dbSNP
rs953418269 2065 dbSNP
rs537337601 2071 dbSNP
rs187872287 2072 dbSNP
rs747972378 2073 dbSNP
rs762008014 2074 dbSNP
rs567817017 2075 dbSNP
rs1195449958 2078 dbSNP
rs755164166 2082 dbSNP
rs1425694682 2085 dbSNP
rs760420105 2090 dbSNP
rs1385207522 2093 dbSNP
rs763898281 2098 dbSNP
rs535558057 2099 dbSNP
rs760518513 2101 dbSNP
rs771080235 2104 dbSNP
rs553872918 2108 dbSNP
rs776479482 2108 dbSNP
rs1462172777 2109 dbSNP
rs774600817 2111 dbSNP
rs761706575 2117 dbSNP
rs1393663786 2122 dbSNP
rs776548725 2124 dbSNP
rs1336852117 2125 dbSNP
rs927462399 2127 dbSNP
rs759636349 2130 dbSNP
rs977194968 2132 dbSNP
rs1299465401 2134 dbSNP
rs1307927584 2145 dbSNP
rs1316306332 2147 dbSNP
rs925712204 2148 dbSNP
rs1226951054 2149 dbSNP
rs781339295 2151 dbSNP
rs752899896 2152 dbSNP
rs763422475 2154 dbSNP
rs1420811586 2155 dbSNP
rs764351380 2160 dbSNP
rs1267245265 2168 dbSNP
rs886049082 2170 dbSNP
rs1460318435 2171 dbSNP
rs1191124332 2172 dbSNP
rs757676916 2173 dbSNP
rs1428339523 2174 dbSNP
rs1169273141 2175 dbSNP
rs753369668 2176 dbSNP
rs556751200 2178 dbSNP
rs114975362 2179 dbSNP
rs777396771 2182 dbSNP
rs1450353140 2197 dbSNP
rs948339149 2198 dbSNP
rs1290621434 2203 dbSNP
rs1177235591 2204 dbSNP
rs747013464 2206 dbSNP
rs545816667 2207 dbSNP
rs765366722 2218 dbSNP
rs867106058 2219 dbSNP
rs750484441 2220 dbSNP
rs368340132 2226 dbSNP
rs745946721 2227 dbSNP
rs1217410113 2229 dbSNP
rs769936824 2229 dbSNP
rs765213102 2231 dbSNP
rs557458200 2232 dbSNP
rs1243240181 2235 dbSNP
rs758412253 2236 dbSNP
rs1004004976 2240 dbSNP
rs766511772 2242 dbSNP
rs764561406 2244 dbSNP
rs1481176539 2250 dbSNP
rs751762865 2251 dbSNP
rs774558574 2252 dbSNP
rs762188974 2255 dbSNP
rs1369622503 2256 dbSNP
rs755349212 2256 dbSNP
rs906566154 2261 dbSNP
rs767941866 2262 dbSNP
rs4251696 2263 dbSNP
rs1465643201 2271 dbSNP
rs1163742142 2277 dbSNP
rs754500857 2278 dbSNP
rs752416734 2279 dbSNP
rs543306658 2280 dbSNP
rs886049083 2286 dbSNP
rs1426297021 2292 dbSNP
rs781592070 2292 dbSNP
rs777431884 2295 dbSNP
rs374976127 2297 dbSNP
rs1316783831 2298 dbSNP
rs748735564 2301 dbSNP
rs1178469075 2302 dbSNP
rs1267603080 2303 dbSNP
rs1438034279 2306 dbSNP
rs1490632749 2310 dbSNP
rs994638330 2311 dbSNP
rs1240222395 2313 dbSNP
rs1029279648 2318 dbSNP
rs1254405131 2324 dbSNP
rs1028671099 2336 dbSNP
rs953315980 2338 dbSNP
rs79141596 2341 dbSNP
rs1380407534 2342 dbSNP
rs1239109393 2350 dbSNP
rs1374413478 2351 dbSNP
rs1310924234 2357 dbSNP
rs1391618935 2367 dbSNP
rs1377803247 2370 dbSNP
rs1300629032 2373 dbSNP
rs1391196296 2375 dbSNP
rs1468013284 2383 dbSNP
rs954016075 2387 dbSNP
rs1008460121 2391 dbSNP
rs1418204968 2392 dbSNP
rs201691620 2398 dbSNP
rs529020970 2409 dbSNP
rs1018605139 2410 dbSNP
rs1183711310 2411 dbSNP
rs1279776750 2415 dbSNP
rs1345778179 2416 dbSNP
rs192945515 2417 dbSNP
rs977098677 2419 dbSNP
rs925659548 2420 dbSNP
rs914533530 2429 dbSNP
rs1309926160 2433 dbSNP
rs1397230345 2444 dbSNP
rs1042935 2449 dbSNP
rs1256835509 2452 dbSNP
rs1355570988 2454 dbSNP
rs773825212 2461 dbSNP
rs1175275316 2466 dbSNP
rs1239715599 2486 dbSNP
rs1440305257 2489 dbSNP
rs1362829043 2492 dbSNP
rs989662143 2495 dbSNP
rs916762592 2499 dbSNP
rs749773766 2503 dbSNP
rs1046607616 2506 dbSNP
rs1167200920 2506 dbSNP
rs1424411750 2511 dbSNP
rs146111672 2514 dbSNP
rs1192850558 2515 dbSNP
rs940659935 2520 dbSNP
rs1487301353 2521 dbSNP
rs1265032134 2528 dbSNP
rs762469235 2534 dbSNP
rs139019732 2535 dbSNP
rs899243237 2538 dbSNP
rs1488055374 2549 dbSNP
rs1263269090 2556 dbSNP
rs1246555030 2562 dbSNP
rs551795242 2569 dbSNP
rs183142712 2576 dbSNP
rs939718019 2579 dbSNP
rs4251697 2583 dbSNP
rs1386514497 2590 dbSNP
rs888971935 2591 dbSNP
rs1008756649 2595 dbSNP
rs549374264 2596 dbSNP
rs1295437392 2602 dbSNP
rs1462227563 2607 dbSNP
rs1018845616 2609 dbSNP
rs1422995817 2612 dbSNP
rs898133477 2614 dbSNP
rs967297625 2615 dbSNP
rs758972461 2618 dbSNP
rs1374688743 2623 dbSNP
rs1049429042 2634 dbSNP
rs886049084 2634 dbSNP
rs1450768119 2642 dbSNP
rs1329745373 2646 dbSNP
rs865836680 2646 dbSNP
rs1211247927 2647 dbSNP
rs1468678724 2648 dbSNP
rs1256830634 2680 dbSNP
rs889698255 2686 dbSNP
rs4251698 2692 dbSNP
rs1448253172 2693 dbSNP
rs1271224810 2703 dbSNP
rs535258327 2713 dbSNP
rs1329708768 2714 dbSNP
rs1369364588 2717 dbSNP
rs1221046664 2718 dbSNP
rs1303942410 2719 dbSNP
rs1441889094 2725 dbSNP
rs1399892321 2733 dbSNP
rs554657425 2737 dbSNP
rs1200171523 2739 dbSNP
rs1010251978 2747 dbSNP
rs915680612 2748 dbSNP
rs1477689182 2749 dbSNP
rs1375697020 2750 dbSNP
rs1195304195 2757 dbSNP
rs1307153459 2761 dbSNP
rs1237136675 2767 dbSNP
rs1202682861 2779 dbSNP
rs553587658 2787 dbSNP
rs775061190 2789 dbSNP
rs1438973683 2793 dbSNP
rs969930659 2798 dbSNP
rs1021679522 2799 dbSNP
rs982250963 2809 dbSNP
rs928179303 2810 dbSNP
rs968861347 2813 dbSNP
rs1458024818 2823 dbSNP
rs1376660599 2826 dbSNP
rs886049085 2828 dbSNP
rs1251082032 2835 dbSNP
rs1336425851 2852 dbSNP
rs1333646199 2853 dbSNP
rs1413801817 2859 dbSNP
rs1036311093 2868 dbSNP
rs1175463915 2874 dbSNP
rs920622433 2876 dbSNP
rs565820084 2878 dbSNP
rs1379456330 2881 dbSNP
rs1050918876 2882 dbSNP
rs1470992373 2882 dbSNP
rs1232933713 2883 dbSNP
rs1042937 2887 dbSNP
rs1186278506 2894 dbSNP
rs1440228312 2896 dbSNP
rs889221583 2897 dbSNP
rs1008702838 2898 dbSNP
rs1040235281 2900 dbSNP
rs539156926 2902 dbSNP
rs903099212 2906 dbSNP
rs1418093584 2908 dbSNP
rs763451867 2909 dbSNP
rs760437244 2913 dbSNP
rs141549130 2915 dbSNP
rs1283849853 2916 dbSNP
rs575907705 2917 dbSNP
rs1445845884 2924 dbSNP
rs1402969388 2926 dbSNP
rs1314573802 2930 dbSNP
rs763913747 2933 dbSNP
rs1325601788 2938 dbSNP
rs1156666985 2940 dbSNP
rs1402055327 2941 dbSNP
rs1408212755 2950 dbSNP
rs1012596765 2952 dbSNP
rs931116488 2953 dbSNP
rs1471492265 2957 dbSNP
rs1348652320 2958 dbSNP
rs1419401419 2965 dbSNP
rs1439156454 2969 dbSNP
rs1488284981 2970 dbSNP
rs555801286 2970 dbSNP
rs889465029 2975 dbSNP
rs1213074709 2978 dbSNP
rs1280308808 2983 dbSNP
rs1318810141 2991 dbSNP
rs1226826893 2992 dbSNP
rs574202499 3002 dbSNP
rs1337032753 3005 dbSNP
rs1294042943 3009 dbSNP
rs778375300 3017 dbSNP
rs1339807712 3023 dbSNP
rs1270962684 3024 dbSNP
rs1432579861 3026 dbSNP
rs886049086 3030 dbSNP
rs756729205 3031 dbSNP
rs7330 3038 dbSNP
rs982241122 3041 dbSNP
rs1021438471 3043 dbSNP
rs555214879 3045 dbSNP
rs573579359 3049 dbSNP
rs1422041922 3050 dbSNP
rs1484589201 3057 dbSNP
rs756925371 3062 dbSNP
rs1475907691 3063 dbSNP
rs765093404 3071 dbSNP
rs187299006 3074 dbSNP
rs920875433 3075 dbSNP
rs1273859242 3079 dbSNP
rs1198048335 3083 dbSNP
rs1474638144 3093 dbSNP
rs1316168899 3094 dbSNP
rs1001663523 3095 dbSNP
rs930612490 3100 dbSNP
rs1050457365 3106 dbSNP
rs1274092342 3109 dbSNP
rs1034729344 3119 dbSNP
rs1396166776 3120 dbSNP
rs10237 3126 dbSNP
rs780883210 3139 dbSNP
rs1164676621 3143 dbSNP
rs1326194145 3148 dbSNP
rs1464593835 3149 dbSNP
rs1397505326 3151 dbSNP
rs1173157753 3153 dbSNP
rs751656637 3155 dbSNP
rs993056687 3159 dbSNP
rs1412064500 3162 dbSNP
rs1438002588 3162 dbSNP
rs1455881021 3162 dbSNP
rs1015170720 3164 dbSNP
rs1178272885 3167 dbSNP
rs962311348 3167 dbSNP
rs1253218527 3179 dbSNP
rs1166071258 3184 dbSNP
rs1308060175 3184 dbSNP
rs1277865572 3190 dbSNP
rs1231737549 3191 dbSNP
rs1372924479 3198 dbSNP
rs1303599935 3199 dbSNP
rs1445668056 3205 dbSNP
rs973565175 3205 dbSNP
rs920806762 3206 dbSNP
rs1359052656 3207 dbSNP
rs1443522280 3207 dbSNP
rs1174601537 3208 dbSNP
rs559115148 3215 dbSNP
rs985228521 3222 dbSNP
rs1158272120 3226 dbSNP
rs1438130691 3227 dbSNP
rs755073014 3235 dbSNP
rs944811759 3248 dbSNP
rs1040223839 3250 dbSNP
rs903041791 3259 dbSNP
rs998706789 3260 dbSNP
rs578085733 3264 dbSNP
rs886049087 3268 dbSNP
rs1414334938 3273 dbSNP
rs1208642729 3285 dbSNP
rs1349777082 3305 dbSNP
rs1280851258 3308 dbSNP
rs1040716924 3316 dbSNP
rs913134005 3318 dbSNP
rs1282268214 3325 dbSNP
rs1391415946 3328 dbSNP
rs946008825 3331 dbSNP
rs1311523749 3334 dbSNP
rs781455059 3335 dbSNP
rs752902575 3339 dbSNP
rs1043277046 3342 dbSNP
rs192280810 3346 dbSNP
rs893060796 3347 dbSNP
rs1228858573 3348 dbSNP
rs1001986580 3357 dbSNP
rs1315015473 3359 dbSNP
rs1218171804 3365 dbSNP
rs1160117155 3376 dbSNP
rs1411798024 3392 dbSNP
rs1423249394 3392 dbSNP
rs1055903712 3401 dbSNP
rs1486638547 3404 dbSNP
rs184666485 3411 dbSNP
rs1012955649 3414 dbSNP
rs1022667954 3421 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1027.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccgGGGU-GGGGUCAgag 5'
             ||:| ||:|| |   
Target 5' aaaCCUAUCCUCACUgcc 3'
 		7 - 24
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000228872.4 | 3UTR | CAACAGAAACCUAUCCUCACUGCCCUCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
66 hsa-miR-4463 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060168 UHMK1 U2AF homology motif kinase 1 2 2
MIRT096415 C5ORF22 chromosome 5 open reading frame 22 2 2
MIRT366792 GNL3L G protein nucleolar 3 like 2 6
MIRT448501 RYBP RING1 and YY1 binding protein 2 2
MIRT454909 SEPT8 septin 8 2 17
MIRT459019 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459809 POTED POTE ankyrin domain family member D 2 8
MIRT475351 IFNLR1 interferon lambda receptor 1 2 2
MIRT476621 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT479292 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT480204 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2 2
MIRT480765 BMP2 bone morphogenetic protein 2 2 2
MIRT481415 ASXL1 additional sex combs like 1, transcriptional regulator 2 2
MIRT482754 HES7 hes family bHLH transcription factor 7 2 10
MIRT483376 SPATA6 spermatogenesis associated 6 2 4
MIRT487803 GPR20 G protein-coupled receptor 20 2 4
MIRT493196 MID1IP1 MID1 interacting protein 1 2 2
MIRT495617 ZNF736 zinc finger protein 736 2 2
MIRT495977 TBC1D19 TBC1 domain family member 19 2 2
MIRT496914 RTKN rhotekin 2 2
MIRT497320 SH3BP5 SH3 domain binding protein 5 2 2
MIRT498993 HAT1 histone acetyltransferase 1 2 10
MIRT500660 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT507809 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508170 FRK fyn related Src family tyrosine kinase 2 4
MIRT509524 INTU inturned planar cell polarity protein 2 8
MIRT509544 BTLA B and T lymphocyte associated 2 8
MIRT515760 KRTAP5-6 keratin associated protein 5-6 2 2
MIRT516036 PTAFR platelet activating factor receptor 2 2
MIRT516935 THAP1 THAP domain containing 1 2 2
MIRT517672 TRIM72 tripartite motif containing 72 2 2
MIRT521149 SFT2D2 SFT2 domain containing 2 2 2
MIRT526292 KY kyphoscoliosis peptidase 2 2
MIRT526917 ZNF772 zinc finger protein 772 2 6
MIRT527796 KLRD1 killer cell lectin like receptor D1 2 2
MIRT529879 RBM43 RNA binding motif protein 43 2 2
MIRT535894 MLEC malectin 2 2
MIRT536651 INIP INTS3 and NABP interacting protein 2 2
MIRT537349 FKBP15 FK506 binding protein 15 2 2
MIRT539658 SERPINH1 serpin family H member 1 2 2
MIRT543388 CC2D2A coiled-coil and C2 domain containing 2A 2 2
MIRT546878 PURB purine rich element binding protein B 2 2
MIRT547980 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT552836 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT555426 PPIC peptidylprolyl isomerase C 2 2
MIRT559550 ARGLU1 arginine and glutamate rich 1 2 4
MIRT560476 ENSA endosulfine alpha 2 2
MIRT561483 TBC1D4 TBC1 domain family member 4 2 2
MIRT561571 SLC6A9 solute carrier family 6 member 9 2 2
MIRT563869 FAM206A family with sequence similarity 206 member A 2 2
MIRT568210 CAV1 caveolin 1 2 2
MIRT569740 GPR173 G protein-coupled receptor 173 2 2
MIRT570623 MAP1B microtubule associated protein 1B 2 2
MIRT570676 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT576586 Ptbp1 polypyrimidine tract binding protein 1 2 2
MIRT640732 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT643705 KIAA0586 KIAA0586 2 2
MIRT644333 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT670466 RSBN1L round spermatid basic protein 1 like 2 2
MIRT672558 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT685442 SLC10A6 solute carrier family 10 member 6 2 2
MIRT686803 SOX12 SRY-box 12 2 2
MIRT694912 THAP6 THAP domain containing 6 2 2
MIRT702222 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT735058 CYP19A1 cytochrome P450 family 19 subfamily A member 1 3 0
MIRT735059 ESR1 estrogen receptor 1 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4463 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4463 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4463 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-4463 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4463 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4463 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4463 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4463 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4463 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4463 Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4463 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4463 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4463 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4463 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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