pre-miRNA Information | |
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pre-miRNA | hsa-mir-1185-1 |
Genomic Coordinates | chr14: 101042977 - 101043062 |
Synonyms | MIRN1185-1, hsa-mir-1185-1, MIR1185-1 |
Description | Homo sapiens miR-1185-1 stem-loop |
Comment | This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-1185-1-3p | ||||||||||||||||||||||||||||||
Sequence | 53| AUAUACAGGGGGAGACUCUUAU |74 | ||||||||||||||||||||||||||||||
Evidence | Not_experimental | ||||||||||||||||||||||||||||||
Experiments | |||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | ZNF608 | ||||||||||||||||||||
Synonyms | NY-REN-36 | ||||||||||||||||||||
Description | zinc finger protein 608 | ||||||||||||||||||||
Transcript | NM_020747 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on ZNF608 | |||||||||||||||||||||
3'UTR of ZNF608 (miRNA target sites are highlighted) |
>ZNF608|NM_020747|3'UTR 1 CAAGATTGGACATGTACATTGTCATGTGACTGGATCACATGGGGAAGCGCTTTATACAGACATCAGTTCCATGGTGTTAA 81 TTTGAAATGCCTTAATGGCAGGCAAAAACCAGTCATTTCATTTTTGTAAATTACAGATTTTATCACAGAGTAACAAATGT 161 TGCTGTAATTAAACTTCTGTTTTATATATATATACGTATACATATCTGTATATATACATATATATATATATAAATATAAA 241 TATATTCTTTACTTTTTGTATCAGTAACCAGGCTCGCACACACAGGGTCTGCTGCCACGTCGCAAACCACTCAGTAAAGG 321 AAATTAAAAATGTATTTGTCATGTTAAAAAGTGTTAGCCACAAAAGGCTACTTACTTTCTTTTCCTTTTCCTTTAAAATT 401 GTAAATAAATAATGTTATGTATCAGTGTGCCTGAACCTTGCATATCCTTCACATATTTCCCATAAGCCCCTCAGAAAGGC 481 TAACTGTGATGATGACACTTTGGTACAATTTAGATGTCTATTTGGTGGCTCCTGTTAAAGACGCACCAGTGTAAAATGTT 561 CCTGTAGTCACTGTTTGTACTTGTGTATTGTGGAAAAAGTACTTTTGGAAGGCATGGGGTTGCCAGTACCACAAAAACTG 641 TGTTGTATATAATGTAAAGATTAAAATGGGGAAATAATGAGCATCTGTGAATAATGAGGTGTCATTTTTTGATAATCTTG 721 AATGGCAAATAACCCAATAGCCTGCGTACCAGAGACATCTGTGATTGTTCTATTACTTGAATAGTTCTACAGTCTTTTTT 801 TTTTTTTAATGTTTACAATTATCCAGTTTTAGAAGAGAGAGACTTTAACGCCATTGCCTGGTTACTTGTTTTATGCTGTA 881 ATCTAGTTTATTTTATGTAAAATGTATATTGAATGCTTTCCTTTTTTATACCTGCCTTAAATAATTTGGCAATCAGAATT 961 AAAAAGTTTTTTTTTTTTTAAAT Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 57507.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM714643. RNA binding protein: AGO2. Condition:completeT1
"PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 57507.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM714643 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repB |
Location of target site | ENST00000504926.1 | 3UTR | UGUAUAUAUACAUAUAUAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM714644 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repA |
Location of target site | ENST00000504926.1 | 3UTR | AUAUAUAUAUACGUAUACAUAUCUGUAUAUAUACAUAUAUAUAUAU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM1065669 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_8 |
Location of target site | ENST00000504926.1 | 3UTR | UAUAUAUACGUAUACAUAUCUGUAUAUAUACAUA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT066415 | TBK1 | TANK binding kinase 1 | ![]() |
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2 | 4 | ||||||
MIRT073567 | NR2F2 | nuclear receptor subfamily 2 group F member 2 | ![]() |
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2 | 2 | ||||||
MIRT074516 | USP1 | ubiquitin specific peptidase 1 | ![]() |
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2 | 4 | ||||||
MIRT080576 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | ![]() |
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2 | 6 | ||||||
MIRT086539 | HSPE1-MOB4 | HSPE1-MOB4 readthrough | ![]() |
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2 | 2 | ||||||
MIRT086547 | MOB4 | MOB family member 4, phocein | ![]() |
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2 | 2 | ||||||
MIRT088684 | EML4 | echinoderm microtubule associated protein like 4 | ![]() |
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2 | 4 | ||||||
MIRT090811 | MBNL1 | muscleblind like splicing regulator 1 | ![]() |
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2 | 4 | ||||||
MIRT095500 | PURA | purine rich element binding protein A | ![]() |
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2 | 2 | ||||||
MIRT109530 | KLHL15 | kelch like family member 15 | ![]() |
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2 | 6 | ||||||
MIRT109807 | ZFX | zinc finger protein, X-linked | ![]() |
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2 | 2 | ||||||
MIRT117888 | ZBTB7A | zinc finger and BTB domain containing 7A | ![]() |
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2 | 2 | ||||||
MIRT120273 | GSK3B | glycogen synthase kinase 3 beta | ![]() |
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2 | 4 | ||||||
MIRT149892 | LDLR | low density lipoprotein receptor | ![]() |
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2 | 2 | ||||||
MIRT178475 | LCOR | ligand dependent nuclear receptor corepressor | ![]() |
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2 | 4 | ||||||
MIRT193445 | RORA | RAR related orphan receptor A | ![]() |
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2 | 2 | ||||||
MIRT198527 | DSG2 | desmoglein 2 | ![]() |
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2 | 2 | ||||||
MIRT226427 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 | ![]() |
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2 | 2 | ||||||
MIRT227669 | SET | SET nuclear proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT320405 | HOXA9 | homeobox A9 | ![]() |
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2 | 2 | ||||||
MIRT407774 | MRPL35 | mitochondrial ribosomal protein L35 | ![]() |
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2 | 2 | ||||||
MIRT439228 | ZMIZ1 | zinc finger MIZ-type containing 1 | ![]() |
1 | 1 | |||||||
MIRT439312 | VAT1L | vesicle amine transport 1 like | ![]() |
1 | 1 | |||||||
MIRT439421 | TMOD1 | tropomodulin 1 | ![]() |
1 | 1 | |||||||
MIRT439446 | TMEM104 | transmembrane protein 104 | ![]() |
1 | 1 | |||||||
MIRT439524 | STIM2 | stromal interaction molecule 2 | ![]() |
1 | 1 | |||||||
MIRT439612 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) | ![]() |
1 | 1 | |||||||
MIRT439997 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | ![]() |
1 | 1 | |||||||
MIRT440017 | PCSK1 | proprotein convertase subtilisin/kexin type 1 | ![]() |
1 | 1 | |||||||
MIRT440131 | NCOA4 | nuclear receptor coactivator 4 | ![]() |
1 | 1 | |||||||
MIRT440311 | LRRC1 | leucine rich repeat containing 1 | ![]() |
1 | 1 | |||||||
MIRT440475 | IAPP | islet amyloid polypeptide | ![]() |
1 | 1 | |||||||
MIRT440511 | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2 | ![]() |
1 | 1 | |||||||
MIRT440617 | FOXA2 | forkhead box A2 | ![]() |
1 | 1 | |||||||
MIRT440666 | FBXL16 | F-box and leucine rich repeat protein 16 | ![]() |
1 | 1 | |||||||
MIRT440705 | ERO1LB | endoplasmic reticulum oxidoreductase 1 beta | ![]() |
1 | 1 | |||||||
MIRT441007 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | ![]() |
1 | 1 | |||||||
MIRT441018 | CAND1 | cullin associated and neddylation dissociated 1 | ![]() |
1 | 1 | |||||||
MIRT441062 | C1orf43 | chromosome 1 open reading frame 43 | ![]() |
1 | 1 | |||||||
MIRT441209 | ARCN1 | archain 1 | ![]() |
1 | 1 | |||||||
MIRT449461 | HAT1 | histone acetyltransferase 1 | ![]() |
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2 | 2 | ||||||
MIRT467104 | SRI | sorcin | ![]() |
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2 | 2 | ||||||
MIRT468060 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | ![]() |
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2 | 10 | ||||||
MIRT468476 | SESN3 | sestrin 3 | ![]() |
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2 | 4 | ||||||
MIRT473533 | MAX | MYC associated factor X | ![]() |
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2 | 2 | ||||||
MIRT473852 | MAP2K4 | mitogen-activated protein kinase kinase 4 | ![]() |
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2 | 2 | ||||||
MIRT474711 | KIF13A | kinesin family member 13A | ![]() |
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2 | 6 | ||||||
MIRT481665 | ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | ![]() |
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2 | 2 | ||||||
MIRT485120 | SF3B3 | splicing factor 3b subunit 3 | ![]() |
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2 | 2 | ||||||
MIRT493055 | MTFR1 | mitochondrial fission regulator 1 | ![]() |
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2 | 2 | ||||||
MIRT504258 | C1orf147 | chromosome 1 open reading frame 147 | ![]() |
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2 | 4 | ||||||
MIRT504361 | ARID1B | AT-rich interaction domain 1B | ![]() |
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2 | 4 | ||||||
MIRT505748 | SENP1 | SUMO1/sentrin specific peptidase 1 | ![]() |
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2 | 8 | ||||||
MIRT506298 | PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | ![]() |
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2 | 6 | ||||||
MIRT508442 | ZNF608 | zinc finger protein 608 | ![]() |
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2 | 4 | ||||||
MIRT512782 | COL4A3BP | collagen type IV alpha 3 binding protein | ![]() |
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2 | 2 | ||||||
MIRT520447 | TSPAN2 | tetraspanin 2 | ![]() |
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2 | 4 | ||||||
MIRT522133 | NRBF2 | nuclear receptor binding factor 2 | ![]() |
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2 | 6 | ||||||
MIRT522395 | MYADM | myeloid associated differentiation marker | ![]() |
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2 | 4 | ||||||
MIRT523397 | GRIK3 | glutamate ionotropic receptor kainate type subunit 3 | ![]() |
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2 | 4 | ||||||
MIRT523938 | E2F8 | E2F transcription factor 8 | ![]() |
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2 | 4 | ||||||
MIRT524349 | CREB1 | cAMP responsive element binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT524711 | BRMS1L | breast cancer metastasis-suppressor 1 like | ![]() |
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2 | 4 | ||||||
MIRT525134 | ZNF256 | zinc finger protein 256 | ![]() |
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2 | 2 | ||||||
MIRT525710 | DCAF12L2 | DDB1 and CUL4 associated factor 12 like 2 | ![]() |
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2 | 2 | ||||||
MIRT531264 | PPIL3 | peptidylprolyl isomerase like 3 | ![]() |
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2 | 2 | ||||||
MIRT538844 | BTG1 | BTG anti-proliferation factor 1 | ![]() |
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2 | 2 | ||||||
MIRT541366 | CDKN1B | cyclin dependent kinase inhibitor 1B | ![]() |
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2 | 2 | ||||||
MIRT542093 | KCNK10 | potassium two pore domain channel subfamily K member 10 | ![]() |
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2 | 6 | ||||||
MIRT543770 | RBM12B | RNA binding motif protein 12B | ![]() |
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2 | 4 | ||||||
MIRT543940 | NCOA7 | nuclear receptor coactivator 7 | ![]() |
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2 | 2 | ||||||
MIRT545150 | GABRG1 | gamma-aminobutyric acid type A receptor gamma1 subunit | ![]() |
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2 | 2 | ||||||
MIRT545842 | ZNF264 | zinc finger protein 264 | ![]() |
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2 | 4 | ||||||
MIRT548057 | GOLGA7 | golgin A7 | ![]() |
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2 | 2 | ||||||
MIRT549242 | ATXN1L | ataxin 1 like | ![]() |
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2 | 4 | ||||||
MIRT551829 | AASDHPPT | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | ![]() |
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2 | 2 | ||||||
MIRT552484 | ZNF136 | zinc finger protein 136 | ![]() |
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2 | 2 | ||||||
MIRT553663 | TGFBR2 | transforming growth factor beta receptor 2 | ![]() |
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2 | 2 | ||||||
MIRT554988 | RAB39B | RAB39B, member RAS oncogene family | ![]() |
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2 | 2 | ||||||
MIRT555760 | PCTP | phosphatidylcholine transfer protein | ![]() |
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2 | 2 | ||||||
MIRT556923 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | ![]() |
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2 | 4 | ||||||
MIRT564991 | WNK1 | WNK lysine deficient protein kinase 1 | ![]() |
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2 | 2 | ||||||
MIRT566458 | PGGT1B | protein geranylgeranyltransferase type I subunit beta | ![]() |
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2 | 2 | ||||||
MIRT566538 | PANK3 | pantothenate kinase 3 | ![]() |
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2 | 2 | ||||||
MIRT567732 | DLX2 | distal-less homeobox 2 | ![]() |
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2 | 2 | ||||||
MIRT570081 | KANSL1L | KAT8 regulatory NSL complex subunit 1 like | ![]() |
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2 | 2 | ||||||
MIRT571735 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT573529 | MDM2 | MDM2 proto-oncogene | ![]() |
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2 | 2 | ||||||
MIRT574459 | RPS16 | ribosomal protein S16 | ![]() |
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2 | 2 | ||||||
MIRT574992 | Phka1 | phosphorylase kinase alpha 1 | ![]() |
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2 | 3 | ||||||
MIRT576349 | Pxdn | peroxidasin | ![]() |
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2 | 2 | ||||||
MIRT610196 | CD99 | CD99 molecule (Xg blood group) | ![]() |
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2 | 4 | ||||||
MIRT612920 | GPRIN3 | GPRIN family member 3 | ![]() |
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2 | 2 | ||||||
MIRT615021 | DUSP6 | dual specificity phosphatase 6 | ![]() |
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2 | 2 | ||||||
MIRT623573 | IRS1 | insulin receptor substrate 1 | ![]() |
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2 | 2 | ||||||
MIRT624437 | CASD1 | CAS1 domain containing 1 | ![]() |
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2 | 2 | ||||||
MIRT628714 | ZNF585A | zinc finger protein 585A | ![]() |
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2 | 2 | ||||||
MIRT639565 | PCK1 | phosphoenolpyruvate carboxykinase 1 | ![]() |
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2 | 4 | ||||||
MIRT641485 | POLA2 | DNA polymerase alpha 2, accessory subunit | ![]() |
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2 | 2 | ||||||
MIRT641657 | PAPOLG | poly(A) polymerase gamma | ![]() |
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2 | 2 | ||||||
MIRT642210 | RUVBL2 | RuvB like AAA ATPase 2 | ![]() |
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2 | 2 | ||||||
MIRT653010 | STX7 | syntaxin 7 | ![]() |
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2 | 2 | ||||||
MIRT656130 | MSH6 | mutS homolog 6 | ![]() |
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2 | 2 | ||||||
MIRT656893 | KIAA2018 | upstream transcription factor family member 3 | ![]() |
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2 | 2 | ||||||
MIRT660130 | BRPF3 | bromodomain and PHD finger containing 3 | ![]() |
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2 | 2 | ||||||
MIRT660855 | AFAP1 | actin filament associated protein 1 | ![]() |
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2 | 2 | ||||||
MIRT676843 | PHKA1 | phosphorylase kinase regulatory subunit alpha 1 | ![]() |
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2 | 3 | ||||||
MIRT681473 | DIP2A | disco interacting protein 2 homolog A | ![]() |
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2 | 2 | ||||||
MIRT682253 | RS1 | retinoschisin 1 | ![]() |
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2 | 2 | ||||||
MIRT694296 | COPB2 | coatomer protein complex subunit beta 2 | ![]() |
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2 | 2 | ||||||
MIRT694401 | ALDH1A3 | aldehyde dehydrogenase 1 family member A3 | ![]() |
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2 | 2 | ||||||
MIRT705277 | BACH1 | BTB domain and CNC homolog 1 | ![]() |
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2 | 2 | ||||||
MIRT720833 | C1orf52 | chromosome 1 open reading frame 52 | ![]() |
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2 | 2 | ||||||
MIRT735713 | SIRT1 | sirtuin 1 | ![]() |
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2 | 0 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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