miRTarBase - #MIRT509802


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pre-miRNA Information
pre-miRNA hsa-mir-3911   
Genomic Coordinates chr9: 127690687 - 127690795
Description Homo sapiens miR-3911 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3911
Sequence 12| UGUGUGGAUCCUGGAGGAGGCA |33
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
431152 7 ClinVar
COSM3847691 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs943029638 2 dbSNP
rs780635543 3 dbSNP
rs371437556 6 dbSNP
rs1135401819 7 dbSNP
rs748706130 14 dbSNP
rs1403241180 15 dbSNP
rs779344153 17 dbSNP
rs755366929 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHAF1B   
Synonyms CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7
Description chromatin assembly factor 1 subunit B
Transcript NM_005441   
Expression
Putative miRNA Targets on CHAF1B
3'UTR of CHAF1B
(miRNA target sites are highlighted)		 
>CHAF1B|NM_005441|3'UTR
   1 TGGGACCTCGGCTTCTGCTCGAAGCCTACCAGGCTCCCGGTGTGTGCAGGGAGACGGTAAAGCTGGAGGTGCCTGAGACC
  81 AGGGCTTCCATGGAGCGGGACACACTGTAAATGGATTTCTATAACAGAAGTGACATGTGTACTGATTTTTCTCCAGAAAT
 161 ATGGATGCTGTTGTATTCAGTATCCATTTTTAACTTGGGACATGAACGTTTTAACGTAGTAAATCCTCTTTTTGATGAGT
 241 TTCTGAAACTGGAGCGGTTCAACGTTATCCAGTGTGAAAATCAGTGAGTCCTCCCTGGCATCCTCGTGAAAGTGCACACA
 321 CTTCATGGAGGGACTCCTTTTCAATAAGAATTAGGAAGATGAGAAAGTAATTTGAGATTTTACTCTGTCGAATTTTAGAG
 401 TATTTGAAGTGATTGTTAGATTTCACTTCTAAGGAGTTGATTGATTAAACTTTGGAAGGTAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acGGAGGAGGUCCU--AGGUGUGu 5'
            | |||||  | |  | ||||| 
Target 5' ggCATCCTCGTGAAAGTGCACACa 3'
 297 - 320 126.00 -16.40
2 
miRNA  3' acggaggAGGUCCUAGGUGugu 5'
                 |:||| |||||:   
Target 5' tgttgtaTTCAGTATCCATttt 3'
 169 - 190 107.00 -12.82
3 
miRNA  3' acggaGGA----GGUCCU--AGGUGUgu 5'
               |||    |||||:  ||||::  
Target 5' aggtgCCTGAGACCAGGGCTTCCATGga 3'
 67 - 94 105.00 -19.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30492041 4 COSMIC
COSN31519041 8 COSMIC
COSN31509706 10 COSMIC
COSN30476841 11 COSMIC
COSN31514810 11 COSMIC
COSN30116325 37 COSMIC
COSN17858474 47 COSMIC
COSN5452941 363 COSMIC
COSN10026208 407 COSMIC
COSN5986280 493 COSMIC
COSN29145828 661 COSMIC
COSN8007416 932 COSMIC
COSN22273454 1014 COSMIC
COSN19448057 1437 COSMIC
COSN19448058 1438 COSMIC
COSN5136233 1493 COSMIC
COSN10026209 1515 COSMIC
COSN16549840 1544 COSMIC
COSN20317282 1617 COSMIC
COSN27442315 1665 COSMIC
COSN8565469 1732 COSMIC
COSN23735626 2094 COSMIC
COSN17846701 2121 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs745779016 3 dbSNP
rs774837946 6 dbSNP
rs1488424231 10 dbSNP
rs758449845 11 dbSNP
rs779982090 14 dbSNP
rs1437983824 18 dbSNP
rs746723654 21 dbSNP
rs768501505 22 dbSNP
rs1211636513 25 dbSNP
rs181653099 26 dbSNP
rs1162381017 27 dbSNP
rs377724094 29 dbSNP
rs1458325354 34 dbSNP
rs916492037 35 dbSNP
rs772745921 36 dbSNP
rs377511926 39 dbSNP
rs202093155 40 dbSNP
rs371122870 41 dbSNP
rs374622617 47 dbSNP
rs753959758 48 dbSNP
rs549374297 56 dbSNP
rs1202759808 57 dbSNP
rs935334426 72 dbSNP
rs1054258666 97 dbSNP
rs893915140 100 dbSNP
rs926456979 103 dbSNP
rs551069142 104 dbSNP
rs937893706 105 dbSNP
rs569223539 122 dbSNP
rs1219037908 134 dbSNP
rs1319326766 135 dbSNP
rs1039907534 137 dbSNP
rs901431320 140 dbSNP
rs1457388680 144 dbSNP
rs998354232 147 dbSNP
rs1025865276 148 dbSNP
rs764225603 153 dbSNP
rs950363595 156 dbSNP
rs1457704054 163 dbSNP
rs1488158924 173 dbSNP
rs531809271 176 dbSNP
rs113542793 182 dbSNP
rs1004575162 198 dbSNP
rs562769843 203 dbSNP
rs1427284365 207 dbSNP
rs1188607115 208 dbSNP
rs551615407 209 dbSNP
rs571857716 216 dbSNP
rs8596 217 dbSNP
rs1271493244 234 dbSNP
rs878953065 235 dbSNP
rs185095355 256 dbSNP
rs1384051987 260 dbSNP
rs757442115 263 dbSNP
rs970554640 264 dbSNP
rs1160079684 265 dbSNP
rs1358174182 269 dbSNP
rs1000698315 272 dbSNP
rs376663242 282 dbSNP
rs1399901919 285 dbSNP
rs1339986287 286 dbSNP
rs567967052 289 dbSNP
rs1435177165 291 dbSNP
rs1366803998 292 dbSNP
rs535409567 305 dbSNP
rs868216083 306 dbSNP
rs555366765 307 dbSNP
rs1165378423 309 dbSNP
rs1428311943 311 dbSNP
rs1390097593 315 dbSNP
rs766946573 318 dbSNP
rs1283717703 322 dbSNP
rs372828379 336 dbSNP
rs1251259703 338 dbSNP
rs575162443 349 dbSNP
rs935311999 363 dbSNP
rs1452429163 367 dbSNP
rs1267713811 368 dbSNP
rs997049069 369 dbSNP
rs1481986680 375 dbSNP
rs1273803559 387 dbSNP
rs1029823318 390 dbSNP
rs1053821784 391 dbSNP
rs1353168478 397 dbSNP
rs915304825 436 dbSNP
rs750736887 443 dbSNP
rs1331335681 461 dbSNP
rs1201415963 466 dbSNP
rs942839601 469 dbSNP
rs1408375248 490 dbSNP
rs544281789 493 dbSNP
rs1441239791 494 dbSNP
rs962337010 495 dbSNP
rs1187418954 497 dbSNP
rs1242060708 498 dbSNP
rs1423088999 501 dbSNP
rs557610606 502 dbSNP
rs113332086 514 dbSNP
rs1439789498 515 dbSNP
rs1379580768 524 dbSNP
rs1179996036 532 dbSNP
rs901316496 534 dbSNP
rs1481934963 540 dbSNP
rs1250846943 543 dbSNP
rs1205727712 545 dbSNP
rs926433139 551 dbSNP
rs959361245 552 dbSNP
rs749928560 559 dbSNP
rs992031948 567 dbSNP
rs1276230617 568 dbSNP
rs1452544394 570 dbSNP
rs934178913 571 dbSNP
rs1047284376 572 dbSNP
rs1357929538 580 dbSNP
rs530185892 585 dbSNP
rs1415092954 587 dbSNP
rs945312270 598 dbSNP
rs1412759153 600 dbSNP
rs887388364 613 dbSNP
rs115117611 614 dbSNP
rs925196186 622 dbSNP
rs1400866184 641 dbSNP
rs540041198 652 dbSNP
rs559981622 654 dbSNP
rs16994069 659 dbSNP
rs1442464723 665 dbSNP
rs1376462283 671 dbSNP
rs1206384464 675 dbSNP
rs1011961942 676 dbSNP
rs1234208280 687 dbSNP
rs1269089522 707 dbSNP
rs899943849 708 dbSNP
rs1364831032 709 dbSNP
rs542583132 719 dbSNP
rs866518866 728 dbSNP
rs1343305339 731 dbSNP
rs1284098069 733 dbSNP
rs1023401309 739 dbSNP
rs1200443540 748 dbSNP
rs970526980 749 dbSNP
rs1259273333 750 dbSNP
rs1459452929 751 dbSNP
rs756062915 752 dbSNP
rs2129798 753 dbSNP
rs1051285698 757 dbSNP
rs1402213705 758 dbSNP
rs1200008764 760 dbSNP
rs1235805384 762 dbSNP
rs1030911573 767 dbSNP
rs1011873203 768 dbSNP
rs1379213056 770 dbSNP
rs1476927923 776 dbSNP
rs956684681 780 dbSNP
rs1464100113 782 dbSNP
rs1175357367 784 dbSNP
rs1424282276 785 dbSNP
rs1467071590 787 dbSNP
rs562883028 790 dbSNP
rs1395824045 791 dbSNP
rs1387628136 792 dbSNP
rs1325756441 793 dbSNP
rs915207807 794 dbSNP
rs368595174 796 dbSNP
rs1015887210 797 dbSNP
rs201247343 802 dbSNP
rs190836496 805 dbSNP
rs182071159 806 dbSNP
rs571769639 809 dbSNP
rs934146358 810 dbSNP
rs1047253469 813 dbSNP
rs151125026 821 dbSNP
rs1480019804 831 dbSNP
rs7275524 832 dbSNP
rs1039032299 846 dbSNP
rs1405816163 847 dbSNP
rs1024772952 848 dbSNP
rs898801117 851 dbSNP
rs1448323736 854 dbSNP
rs749185430 859 dbSNP
rs779727318 867 dbSNP
rs1187860004 870 dbSNP
rs1487310591 876 dbSNP
rs977894204 876 dbSNP
rs925228822 884 dbSNP
rs1449473119 889 dbSNP
rs1273079961 891 dbSNP
rs936572765 892 dbSNP
rs1342914219 894 dbSNP
rs866362674 895 dbSNP
rs906311071 896 dbSNP
rs1168439837 897 dbSNP
rs567058820 900 dbSNP
rs1372633775 903 dbSNP
rs1294407431 904 dbSNP
rs921241457 912 dbSNP
rs768177637 914 dbSNP
rs1165037317 915 dbSNP
rs1171914887 916 dbSNP
rs1254677065 916 dbSNP
rs749576099 916 dbSNP
rs774367943 916 dbSNP
rs1431021945 924 dbSNP
rs1388876305 928 dbSNP
rs1039223300 930 dbSNP
rs1250107369 930 dbSNP
rs540433867 930 dbSNP
rs746908856 930 dbSNP
rs774375568 930 dbSNP
rs1205013270 931 dbSNP
rs1030878983 932 dbSNP
rs956750337 934 dbSNP
rs1299235723 942 dbSNP
rs1342772240 948 dbSNP
rs1225621436 949 dbSNP
rs1347113839 952 dbSNP
rs1051145266 953 dbSNP
rs989379491 953 dbSNP
rs187226984 955 dbSNP
rs189927002 956 dbSNP
rs1299878402 961 dbSNP
rs1410140728 963 dbSNP
rs1464087185 963 dbSNP
rs1470765717 963 dbSNP
rs550243275 963 dbSNP
rs7280190 965 dbSNP
rs1253270353 966 dbSNP
rs1266641928 967 dbSNP
rs1353874295 971 dbSNP
rs1482947634 972 dbSNP
rs996131044 972 dbSNP
rs1221236005 973 dbSNP
rs537491648 974 dbSNP
rs1489140033 983 dbSNP
rs778013275 985 dbSNP
rs1227544337 996 dbSNP
rs1191165510 1003 dbSNP
rs145013661 1004 dbSNP
rs577328318 1005 dbSNP
rs1189766608 1020 dbSNP
rs1377751303 1028 dbSNP
rs1013198989 1029 dbSNP
rs908673871 1033 dbSNP
rs1424340498 1039 dbSNP
rs1158038660 1040 dbSNP
rs533711144 1050 dbSNP
rs1038591807 1051 dbSNP
rs1024720650 1060 dbSNP
rs1163239287 1062 dbSNP
rs916175145 1065 dbSNP
rs868828621 1067 dbSNP
rs1044788734 1068 dbSNP
rs906281710 1069 dbSNP
rs1209640431 1077 dbSNP
rs1003255476 1078 dbSNP
rs529029230 1079 dbSNP
rs1398277365 1081 dbSNP
rs146776913 1096 dbSNP
rs1242448458 1098 dbSNP
rs1011175556 1100 dbSNP
rs1321052123 1108 dbSNP
rs1315723928 1119 dbSNP
rs180723643 1121 dbSNP
rs1362462614 1125 dbSNP
rs1319429999 1126 dbSNP
rs921284331 1128 dbSNP
rs542897476 1130 dbSNP
rs964338961 1132 dbSNP
rs218632 1137 dbSNP
rs1029577296 1138 dbSNP
rs1457779260 1143 dbSNP
rs955380783 1146 dbSNP
rs185822474 1151 dbSNP
rs940071734 1153 dbSNP
rs908636198 1167 dbSNP
rs771564845 1171 dbSNP
rs962893701 1174 dbSNP
rs974678339 1176 dbSNP
rs1263500851 1180 dbSNP
rs1202104551 1184 dbSNP
rs1207837435 1184 dbSNP
rs916158501 1196 dbSNP
rs1248127519 1198 dbSNP
rs145667793 1201 dbSNP
rs565340948 1208 dbSNP
rs1227622940 1209 dbSNP
rs1327829920 1210 dbSNP
rs1046018002 1214 dbSNP
rs745923946 1216 dbSNP
rs895398925 1217 dbSNP
rs190149225 1226 dbSNP
rs939012453 1228 dbSNP
rs1305448762 1232 dbSNP
rs1438006589 1233 dbSNP
rs547941817 1234 dbSNP
rs561453592 1240 dbSNP
rs892238594 1241 dbSNP
rs1468086880 1242 dbSNP
rs1301593163 1243 dbSNP
rs999207693 1247 dbSNP
rs1032179446 1251 dbSNP
rs1432354012 1257 dbSNP
rs1010732214 1258 dbSNP
rs1269367810 1267 dbSNP
rs1482038926 1268 dbSNP
rs376864284 1273 dbSNP
rs1309296768 1284 dbSNP
rs1043990317 1285 dbSNP
rs1232123524 1289 dbSNP
rs369457759 1289 dbSNP
rs138215273 1290 dbSNP
rs1029364094 1293 dbSNP
rs1408468599 1294 dbSNP
rs954592067 1297 dbSNP
rs1378721148 1308 dbSNP
rs1221685876 1316 dbSNP
rs986827906 1320 dbSNP
rs374199909 1321 dbSNP
rs1172168553 1344 dbSNP
rs1470436171 1349 dbSNP
rs1429656673 1350 dbSNP
rs1312546650 1353 dbSNP
rs1471522128 1354 dbSNP
rs1211910663 1355 dbSNP
rs1250963701 1364 dbSNP
rs1261185349 1372 dbSNP
rs1460788793 1377 dbSNP
rs899677831 1381 dbSNP
rs550447688 1382 dbSNP
rs1029546296 1395 dbSNP
rs1323817135 1398 dbSNP
rs1240077127 1400 dbSNP
rs955349737 1407 dbSNP
rs1004190918 1412 dbSNP
rs1226927905 1418 dbSNP
rs377379355 1420 dbSNP
rs1015667395 1421 dbSNP
rs1445029667 1423 dbSNP
rs1338721654 1425 dbSNP
rs963155330 1435 dbSNP
rs931513904 1447 dbSNP
rs974267948 1461 dbSNP
rs1408564140 1468 dbSNP
rs1157280248 1469 dbSNP
rs916026443 1473 dbSNP
rs1176828959 1474 dbSNP
rs1159026611 1482 dbSNP
rs537418547 1488 dbSNP
rs981662433 1489 dbSNP
rs928891655 1493 dbSNP
rs916846139 1494 dbSNP
rs938981482 1504 dbSNP
rs1206477035 1505 dbSNP
rs949609729 1508 dbSNP
rs149096619 1511 dbSNP
rs770461221 1512 dbSNP
rs111472207 1515 dbSNP
rs1246779128 1519 dbSNP
rs946419078 1520 dbSNP
rs1043489531 1523 dbSNP
rs1331488628 1525 dbSNP
rs1401840475 1539 dbSNP
rs1434675149 1543 dbSNP
rs899645058 1546 dbSNP
rs932503956 1547 dbSNP
rs1402301158 1553 dbSNP
rs1411520183 1558 dbSNP
rs1162905333 1566 dbSNP
rs1439646192 1568 dbSNP
rs1444678894 1568 dbSNP
rs1050949910 1570 dbSNP
rs776170091 1571 dbSNP
rs1367789995 1581 dbSNP
rs1004211439 1592 dbSNP
rs1220774348 1595 dbSNP
rs1016052938 1614 dbSNP
rs763500206 1615 dbSNP
rs537807257 1616 dbSNP
rs1219127787 1617 dbSNP
rs1289756329 1622 dbSNP
rs996433661 1628 dbSNP
rs1260150415 1649 dbSNP
rs1028811193 1652 dbSNP
rs1295513640 1652 dbSNP
rs747533741 1652 dbSNP
rs1272208999 1654 dbSNP
rs1305821735 1665 dbSNP
rs1347940965 1666 dbSNP
rs1302423492 1667 dbSNP
rs143123942 1672 dbSNP
rs570937437 1680 dbSNP
rs1008795903 1681 dbSNP
rs1427476318 1682 dbSNP
rs1419770367 1690 dbSNP
rs1187941798 1693 dbSNP
rs1489565176 1694 dbSNP
rs995963540 1698 dbSNP
rs961333339 1699 dbSNP
rs1023069588 1701 dbSNP
rs1273193518 1702 dbSNP
rs183844901 1709 dbSNP
rs970191477 1710 dbSNP
rs981631513 1711 dbSNP
rs1035935598 1714 dbSNP
rs956313969 1719 dbSNP
rs868542761 1721 dbSNP
rs1347315960 1728 dbSNP
rs1422039464 1730 dbSNP
rs913524055 1754 dbSNP
rs991408874 1757 dbSNP
rs1354645822 1759 dbSNP
rs1169092343 1761 dbSNP
rs946413499 1766 dbSNP
rs979565024 1768 dbSNP
rs916726825 1773 dbSNP
rs921034559 1775 dbSNP
rs148278624 1777 dbSNP
rs932471480 1782 dbSNP
rs1050921661 1792 dbSNP
rs1177180619 1795 dbSNP
rs891040963 1797 dbSNP
rs1234692576 1802 dbSNP
rs573774333 1805 dbSNP
rs935029273 1806 dbSNP
rs1053436769 1808 dbSNP
rs2898286 1809 dbSNP
rs1400597152 1810 dbSNP
rs1304735155 1815 dbSNP
rs1390772819 1822 dbSNP
rs931719568 1828 dbSNP
rs1299390715 1836 dbSNP
rs1445264950 1838 dbSNP
rs1280031412 1840 dbSNP
rs1176774445 1845 dbSNP
rs898462529 1848 dbSNP
rs1050705020 1849 dbSNP
rs1158950526 1852 dbSNP
rs751589270 1855 dbSNP
rs1252671206 1859 dbSNP
rs1214092817 1869 dbSNP
rs188340013 1872 dbSNP
rs1323773552 1882 dbSNP
rs1205855683 1885 dbSNP
rs1462450143 1898 dbSNP
rs1258755560 1899 dbSNP
rs576271006 1902 dbSNP
rs1291583125 1903 dbSNP
rs1309136509 1907 dbSNP
rs1243114726 1911 dbSNP
rs1381460034 1920 dbSNP
rs147354551 1925 dbSNP
rs540120404 1927 dbSNP
rs890253927 1935 dbSNP
rs1386831235 1936 dbSNP
rs574483815 1937 dbSNP
rs1035820595 1938 dbSNP
rs572508686 1946 dbSNP
rs541530524 1947 dbSNP
rs897728170 1951 dbSNP
rs994604791 1952 dbSNP
rs1161266460 1956 dbSNP
rs561415373 1965 dbSNP
rs1204323498 1967 dbSNP
rs763102152 1975 dbSNP
rs572963001 1976 dbSNP
rs1358041528 1980 dbSNP
rs970905605 1980 dbSNP
rs1247626973 1985 dbSNP
rs191662053 1992 dbSNP
rs1324312633 2001 dbSNP
rs982244273 2007 dbSNP
rs1284924824 2008 dbSNP
rs1301792304 2010 dbSNP
rs1424600987 2011 dbSNP
rs1381413503 2013 dbSNP
rs563973361 2022 dbSNP
rs879532023 2028 dbSNP
rs768436209 2039 dbSNP
rs924217103 2043 dbSNP
rs921006671 2056 dbSNP
rs1447797970 2058 dbSNP
rs532672843 2060 dbSNP
rs755970256 2063 dbSNP
rs989562777 2070 dbSNP
rs1314640943 2074 dbSNP
rs986518315 2075 dbSNP
rs914886133 2080 dbSNP
rs1490166675 2084 dbSNP
rs552485153 2085 dbSNP
rs1354636886 2092 dbSNP
rs939883594 2093 dbSNP
rs1037332911 2094 dbSNP
rs919878638 2114 dbSNP
rs1328509105 2121 dbSNP
rs890199773 2124 dbSNP
rs1404795573 2138 dbSNP
rs1346683403 2141 dbSNP
rs570900226 2143 dbSNP
rs527331698 2146 dbSNP
rs1044454262 2151 dbSNP
rs1036185130 2156 dbSNP
rs547040422 2160 dbSNP
rs183888868 2174 dbSNP
rs994741503 2175 dbSNP
rs1445936146 2185 dbSNP
rs1181140003 2187 dbSNP
rs112100545 2189 dbSNP
rs1439873634 2193 dbSNP
rs114229582 2198 dbSNP
rs1160134128 2210 dbSNP
rs1249234485 2219 dbSNP
rs556104815 2223 dbSNP
rs1382505513 2236 dbSNP
rs1341035489 2254 dbSNP
rs1012655521 2256 dbSNP
rs1023715938 2274 dbSNP
rs1334764695 2277 dbSNP
rs891933064 2278 dbSNP
rs1003693562 2283 dbSNP
rs1010424878 2304 dbSNP
rs1329625445 2309 dbSNP
rs1031096983 2311 dbSNP
rs1450586131 2317 dbSNP
rs766115735 2321 dbSNP
rs1314413352 2325 dbSNP
rs1176039281 2328 dbSNP
rs1469072761 2338 dbSNP
rs569863483 2344 dbSNP
rs1174199470 2345 dbSNP
rs1242548125 2346 dbSNP
rs1278211182 2347 dbSNP
rs969029566 2364 dbSNP
rs1181888472 2374 dbSNP
rs754844489 2376 dbSNP
rs1240854364 2377 dbSNP
rs1202678884 2380 dbSNP
rs1027907954 2398 dbSNP
rs1265407044 2399 dbSNP
rs538921740 2408 dbSNP
rs541514900 2409 dbSNP
rs953107324 2410 dbSNP
rs912332804 2413 dbSNP
rs371044853 2415 dbSNP
rs1336274843 2416 dbSNP
rs1457988186 2426 dbSNP
rs972621828 2436 dbSNP
rs1406469794 2439 dbSNP
rs1183518628 2443 dbSNP
rs1335933985 2444 dbSNP
rs865873001 2451 dbSNP
rs1361650748 2453 dbSNP
rs911673867 2455 dbSNP
rs1469443407 2456 dbSNP
rs1159117095 2462 dbSNP
rs1172909448 2463 dbSNP
rs1440960252 2465 dbSNP
rs553681128 2465 dbSNP
rs558936139 2466 dbSNP
rs572470233 2468 dbSNP
rs944410894 2470 dbSNP
rs1182542339 2471 dbSNP
rs1036216182 2477 dbSNP
rs377422975 2479 dbSNP
rs1336211434 2482 dbSNP
rs1207440834 2483 dbSNP
rs577107606 2483 dbSNP
rs79511009 2483 dbSNP
rs77804805 2484 dbSNP
rs1401113975 2485 dbSNP
rs1357311331 2486 dbSNP
rs1393413342 2486 dbSNP
rs1314479498 2493 dbSNP
rs1246890837 2496 dbSNP
rs1385248564 2497 dbSNP
rs868331120 2497 dbSNP
rs1428350595 2498 dbSNP
rs1327115965 2499 dbSNP
rs1335324668 2501 dbSNP
rs1318836906 2503 dbSNP
rs1363095898 2504 dbSNP
rs930566518 2504 dbSNP
rs1049008254 2507 dbSNP
rs374098682 2509 dbSNP
rs919830591 2526 dbSNP
rs1012228048 2528 dbSNP
rs1045029855 2541 dbSNP
rs1475267578 2554 dbSNP
rs1243075944 2555 dbSNP
rs931206005 2566 dbSNP
rs1490003998 2579 dbSNP
rs761663220 2584 dbSNP
rs1044342552 2597 dbSNP
rs1223289211 2600 dbSNP
rs778464790 2603 dbSNP
rs1003557698 2616 dbSNP
rs1318019509 2617 dbSNP
rs1031129528 2619 dbSNP
rs956861893 2623 dbSNP
rs1248020188 2625 dbSNP
rs927250084 2627 dbSNP
rs1199373462 2630 dbSNP
rs1022583274 2633 dbSNP
rs1270744384 2637 dbSNP
rs865994119 2639 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 8208.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8208.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acggaggagguccuagGUGUGu 5'
                          ||||| 
Target 5' ----------------CACACa 3'
 		1 - 6
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000314103.5 | 3UTR | ACACACACACAUAUAUAUGAUACAUAUAUAUAUAUAUACACACACACACAAGUAUGUGUGUAUAUAUAUAUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000314103.5 | 3UTR | CCACACACACACAUAUAUAUGAUACAUAUAUAUAUAUAUACACACACACACAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000314103.5 | 3UTR | ACACACACACAUAUAUAUGAUACAUAUAUAUAUAUAUACACACACACACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000314103.5 | 3UTR | CACACACACACAUAUAUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.89 0.05 -0.800 0.1 4 Click to see details
LUSC -0.762 0.12 -0.600 0.2 4 Click to see details
HNSC -0.176 0.35 -0.143 0.38 7 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
BRCA 0.22 0.36 0.200 0.37 5 Click to see details
70 hsa-miR-3911 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT207399 MAT2A methionine adenosyltransferase 2A 2 6
MIRT284537 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT291946 TPM4 tropomyosin 4 2 2
MIRT293609 PVR poliovirus receptor 2 2
MIRT357688 PAIP2 poly(A) binding protein interacting protein 2 2 2
MIRT451607 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452110 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT457804 KLHL25 kelch like family member 25 2 2
MIRT462730 EFNB1 ephrin B1 2 2
MIRT463219 ZNF131 zinc finger protein 131 2 2
MIRT464141 VPS28 VPS28, ESCRT-I subunit 2 2
MIRT467582 SLC7A5 solute carrier family 7 member 5 2 6
MIRT470824 PLXND1 plexin D1 2 2
MIRT474230 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT478989 COLGALT1 collagen beta(1-O)galactosyltransferase 1 2 2
MIRT479462 CDK6 cyclin dependent kinase 6 2 2
MIRT483558 SYT2 synaptotagmin 2 2 2
MIRT484483 SLC9A1 solute carrier family 9 member A1 2 2
MIRT485224 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT490356 DPYSL5 dihydropyrimidinase like 5 2 4
MIRT493177 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT509802 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511815 HDGF heparin binding growth factor 2 2
MIRT512254 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT513025 GPT2 glutamic--pyruvic transaminase 2 2 2
MIRT519640 ZNF772 zinc finger protein 772 2 4
MIRT531178 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT537870 EDA2R ectodysplasin A2 receptor 2 2
MIRT551914 IGLON5 IgLON family member 5 2 2
MIRT558359 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT559771 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 4
MIRT559813 ZNF83 zinc finger protein 83 2 2
MIRT561999 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT565754 SERTAD2 SERTA domain containing 2 2 2
MIRT569423 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT569845 RGS5 regulator of G protein signaling 5 2 2
MIRT606928 CDK15 cyclin dependent kinase 15 2 2
MIRT607616 TMEM130 transmembrane protein 130 2 4
MIRT607629 TRIOBP TRIO and F-actin binding protein 2 2
MIRT607885 SATB1 SATB homeobox 1 2 2
MIRT607942 SSX2 SSX family member 2 2 4
MIRT608017 CARNS1 carnosine synthase 1 2 4
MIRT608036 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT608063 SSX2B SSX family member 2B 2 4
MIRT608558 SBK1 SH3 domain binding kinase 1 2 6
MIRT608915 NCDN neurochondrin 2 6
MIRT615876 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT618023 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT620505 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT628101 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 2
MIRT628700 ZNF548 zinc finger protein 548 2 2
MIRT630658 POU2F1 POU class 2 homeobox 1 2 2
MIRT643508 ZNF28 zinc finger protein 28 2 2
MIRT646379 SLC22A6 solute carrier family 22 member 6 2 2
MIRT660041 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT687700 KRR1 KRR1, small subunit processome component homolog 2 2
MIRT688858 CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 2 2
MIRT690443 REPIN1 replication initiator 1 2 2
MIRT690456 ZNF33A zinc finger protein 33A 2 2
MIRT693796 RHOG ras homolog family member G 2 2
MIRT694274 ZNF529 zinc finger protein 529 2 4
MIRT697697 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700242 RCC2 regulator of chromosome condensation 2 2 2
MIRT701836 MRPL37 mitochondrial ribosomal protein L37 2 2
MIRT704255 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT707203 SDK2 sidekick cell adhesion molecule 2 2 2
MIRT710365 CREB5 cAMP responsive element binding protein 5 2 2
MIRT711943 WDFY1 WD repeat and FYVE domain containing 1 2 2
MIRT715496 MAZ MYC associated zinc finger protein 2 2
MIRT719250 MS4A1 membrane spanning 4-domains A1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3911 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3911 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3911 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3911 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3911 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-mir-3911 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-3911 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-3911 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3911 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3911 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3911 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3911 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3911 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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