miRTarBase - #MIRT509851


—
pre-miRNA Information
pre-miRNA hsa-mir-3622a   
Genomic Coordinates chr8: 27701677 - 27701759
Description Homo sapiens miR-3622a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622a-3p
Sequence 50| UCACCUGACCUCCCAUGCCUGU |71
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 8 + 27701728 27229138, 28411194, 29165639 MiREDiBase
A-to-I 8 8 + 27701733 29233923 MiREDiBase
A-to-I 15 8 + 27701740 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs367834969 9 dbSNP
rs1444523018 11 dbSNP
rs551029921 14 dbSNP
rs569771074 15 dbSNP
rs13276615 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol BIRC5   
Synonyms API4, EPR-1
Description baculoviral IAP repeat containing 5
Transcript NM_001012271   
Other Transcripts NM_001012270 , NM_001168   
Expression
Putative miRNA Targets on BIRC5
3'UTR of BIRC5
(miRNA target sites are highlighted)		 
>BIRC5|NM_001012271|3'UTR
   1 GGCCTCTGGCCGGAGCTGCCTGGTCCCAGAGTGGCTGCACCACTTCCAGGGTTTATTCCCTGGTGCCACCAGCCTTCCTG
  81 TGGGCCCCTTAGCAATGTCTTAGGAAAGGAGATCAACATTTTCAAATTAGATGTTTCAACTGTGCTCTTGTTTTGTCTTG
 161 AAAGTGGCACCAGAGGTGCTTCTGCCTGTGCAGCGGGTGCTGCTGGTAACAGTGGCTGCTTCTCTCTCTCTCTCTCTTTT
 241 TTGGGGGCTCATTTTTGCTGTTTTGATTCCCGGGCTTACCAGGTGAGAAGTGAGGGAGGAAGAAGGCAGTGTCCCTTTTG
 321 CTAGAGCTGACAGCTTTGTTCGCGTGGGCAGAGCCTTCCACAGTGAATGTGTCTGGACCTCATGTTGTTGAGGCTGTCAC
 401 AGTCCTGAGTGTGGACTTGGCAGGTGCCTGTTGAATCTGAGCTGCAGGTTCCTTATCTGTCACACCTGTGCCTCCTCAGA
 481 GGACAGTTTTTTTGTTGTTGTGTTTTTTTGTTTTTTTTTTTTTGGTAGATGCATGACTTGTGTGTGATGAGAGAATGGAG
 561 ACAGAGTCCCTGGCTCCTCTACTGTTTAACAACATGGCTTTCTTATTTTGTTTGAATTGTTAATTCACAGAATAGCACAA
 641 ACTACAATTAAAACTAAGCACAAAGCCATTCTAAGTCATTGGGGAAACGGGGTGAACTTCAGGTGGATGAGGAGACAGAA
 721 TAGAGTGATAGGAAGCGTCTGGCAGATACTCCTTTTGCCACTGCTGTGTGATTAGACAGGCCCAGTGAGCCGCGGGGCAC
 801 ATGCTGGCCGCTCCTCCCTCAGAAAAAGGCAGTGGCCTAAATCCTTTTTAAATGACTTGGCTCGATGCTGTGGGGGACTG
 881 GCTGGGCTGCTGCAGGCCGTGTGTCTGTCAGCCCAACCTTCACATCTGTCACGTTCTCCACACGGGGGAGAGACGCAGTC
 961 CGCCCAGGTCCCCGCTTTCTTTGGAGGCAGCAGCTCCCGCAGGGCTGAAGTCTGGCGTAAGATGATGGATTTGATTCGCC
1041 CTCCTCCCTGTCATAGAGCTGCAGGGTGGATTGTTACAGCTTCGCTGGAAACCTCTGGAGGTCATCTCGGCTGTTCCTGA
1121 GAAATAAAAAGCCTGTCATTTCAAACACTGCTGTGGACCCTACTGGGTTTTTAAAATATTGTCAGTTTTTCATCGTCGTC
1201 CCTAGCCTGCCAACAGCCATCTGCCCAGACAGCCGCAGTGAGGATGAGCGTCCTGGCAGAGACGCAGTTGTCTCTGGGCG
1281 CTTGCCAGAGCCACGAACCCCAGACCTGTTTGTATCATCCGGGCTCCTTCCGGGCAGAAACAACTGAAAATGCACTTCAG
1361 ACCCACTTATTTCTGCCACATCTGAGTCGGCCTGAGATAGACTTTTCCCTCTAAACTGGGAGAATATCACAGTGGTTTTT
1441 GTTAGCAGAAAATGCACTCCAGCCTCTGTACTCATCTAAGCTGCTTATTTTTGATATTTGTGTCAGTCTGTAAATGGATA
1521 CTTCACTTTAATAACTGTTGCTTAGTAATTGGCTTTGTAGAGAAGCTGGAAAAAAATGGTTTTGTCTTCAACTCCTTTGC
1601 ATGCCAGGCGGTGATGTGGATCTCGGCTTCTGTGAGCCTGTGCTGTGGGCAGGGCTGAGCTGGAGCCGCCCCTCTCAGCC
1681 CGCCTGCCACGGCCTTTCCTTAAAGGCCATCCTTAAAACCAGACCCTCATGGCTACCAGCACCTGAAAGCTTCCTCGACA
1761 TCTGTTAATAAAGCCGTAGGCCCTTGTCTAAGTGCAACCGCCTAGACTTTCTTTCAGATACATGTCCACATGTCCATTTT
1841 TCAGGTTCTCTAAGTTGGAGTGGAGTCTGGGAAGGGTTGTGAATGAGGCTTCTGGGCTATGGGTGAGGTTCCAATGGCAG
1921 GTTAGAGCCCCTCGGGCCAACTGCCATCCTGGAAAGTAGAGACAGCAGTGCCCGCTGCCCAGAAGAGACCAGCAAGCCAA
2001 ACTGGAGCCCCCATTGCAGGCTGTCGCCATGTGGAAAGAGTAACTCACAATTGCCAATAAAGTCTCATGTGGTTTTATCT
2081 AAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUCCGUA--CCCU-----CC------AGUCCACu 5'
            || |||  ||||     ||      ||||||| 
Target 5' taAGTCATTGGGGAAACGGGGTGAACTTCAGGTGg 3'
 672 - 706 148.00 -18.60
2 
miRNA  3' uguccguacccuccAGUCCAcu 5'
                        ||||||  
Target 5' cacatgtccattttTCAGGTtc 3'
 1827 - 1848 120.00 -8.42
3 
miRNA  3' uguccguacccuccaGUCCACu 5'
                         |||||| 
Target 5' gattcccgggcttacCAGGTGa 3'
 265 - 286 120.00 -15.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM7457208 3 COSMIC
COSM7954829 11 COSMIC
COSM5646702 30 COSMIC
COSM8035166 48 COSMIC
COSM985068 59 COSMIC
COSM7946875 78 COSMIC
COSM8807253 84 COSMIC
COSM5524330 99 COSMIC
COSM1589261 100 COSMIC
COSN228482 106 COSMIC
COSM8466621 145 COSMIC
COSM8277992 146 COSMIC
COSM3820768 149 COSMIC
COSM5713323 150 COSMIC
COSM1610893 160 COSMIC
COSM1480111 237 COSMIC
COSM7693061 237 COSMIC
COSM9368754 314 COSMIC
COSM9404272 316 COSMIC
COSM9384980 325 COSMIC
COSN20114489 500 COSMIC
COSN20114491 500 COSMIC
COSN17474715 511 COSMIC
COSN18783147 511 COSMIC
COSN20114492 511 COSMIC
COSN15657350 512 COSMIC
COSN15657316 522 COSMIC
COSN15657326 523 COSMIC
COSN15657381 524 COSMIC
COSN17363415 689 COSMIC
COSM5794977 890 COSMIC
COSM5783275 945 COSMIC
COSM9478746 949 COSMIC
COSM9478743 955 COSMIC
COSM9370572 980 COSMIC
COSM9478745 1019 COSMIC
COSM9478744 1021 COSMIC
COSN4770657 1935 COSMIC
COSN9323436 2047 COSMIC
COSN29509441 2064 COSMIC
rs17879146 311 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs760508738 3 dbSNP
rs1188637224 5 dbSNP
rs112471026 12 dbSNP
rs776613516 13 dbSNP
rs1217843298 17 dbSNP
rs1170140374 19 dbSNP
rs761747371 20 dbSNP
rs370922732 23 dbSNP
rs1310191201 28 dbSNP
rs561843820 29 dbSNP
rs749926799 38 dbSNP
rs1377462147 39 dbSNP
rs1396792895 41 dbSNP
rs758031351 44 dbSNP
rs373086357 47 dbSNP
rs17885521 51 dbSNP
rs1225238355 52 dbSNP
rs377394472 53 dbSNP
rs778286403 58 dbSNP
rs749753633 59 dbSNP
rs757860515 69 dbSNP
rs779009224 71 dbSNP
rs1329079217 83 dbSNP
rs745971364 84 dbSNP
rs772312741 85 dbSNP
rs1261549356 87 dbSNP
rs754622241 92 dbSNP
rs140169554 97 dbSNP
rs1359636644 98 dbSNP
rs957467589 101 dbSNP
rs17882627 105 dbSNP
rs762868101 110 dbSNP
rs761692199 112 dbSNP
rs1178792701 116 dbSNP
rs765120054 118 dbSNP
rs780850257 119 dbSNP
rs938705528 120 dbSNP
rs1158208097 122 dbSNP
rs1383978350 132 dbSNP
rs747777761 134 dbSNP
rs772749498 140 dbSNP
rs1365793433 142 dbSNP
rs188097548 143 dbSNP
rs922951036 146 dbSNP
rs1491029952 148 dbSNP
rs796491719 148 dbSNP
rs2239680 149 dbSNP
rs17882139 150 dbSNP
rs766041929 151 dbSNP
rs779690492 161 dbSNP
rs751323998 163 dbSNP
rs1349009382 168 dbSNP
rs754690546 177 dbSNP
rs898021487 189 dbSNP
rs1269128376 195 dbSNP
rs1468464730 196 dbSNP
rs1192294254 204 dbSNP
rs929468494 206 dbSNP
rs1051500460 209 dbSNP
rs1047418031 215 dbSNP
rs1302130941 220 dbSNP
rs369792774 221 dbSNP
rs747343335 221 dbSNP
rs777250034 221 dbSNP
rs1181381107 225 dbSNP
rs1418616207 227 dbSNP
rs772563554 227 dbSNP
rs1402486381 237 dbSNP
rs775748394 237 dbSNP
rs1166545623 239 dbSNP
rs908991160 242 dbSNP
rs893733975 243 dbSNP
rs1255911482 249 dbSNP
rs764503657 251 dbSNP
rs1489571172 257 dbSNP
rs1264595539 258 dbSNP
rs1389077757 260 dbSNP
rs1460912743 262 dbSNP
rs1215952195 270 dbSNP
rs1487385286 271 dbSNP
rs1021280400 272 dbSNP
rs941788563 279 dbSNP
rs138133959 280 dbSNP
rs1369113856 307 dbSNP
rs894613464 309 dbSNP
rs17879146 311 dbSNP
rs1305885915 315 dbSNP
rs566341645 318 dbSNP
rs1263990577 321 dbSNP
rs1342268485 324 dbSNP
rs1298775643 334 dbSNP
rs907451552 336 dbSNP
rs1035781513 338 dbSNP
rs1229825411 342 dbSNP
rs779336150 343 dbSNP
rs141087478 344 dbSNP
rs17878866 345 dbSNP
rs957687466 347 dbSNP
rs1479032435 366 dbSNP
rs1424969797 368 dbSNP
rs1193643199 380 dbSNP
rs915935753 383 dbSNP
rs1267694783 388 dbSNP
rs942011585 393 dbSNP
rs1220429661 403 dbSNP
rs1488862514 410 dbSNP
rs1011628017 412 dbSNP
rs186338705 413 dbSNP
rs1211555877 418 dbSNP
rs767165758 424 dbSNP
rs1476573615 425 dbSNP
rs1462871485 427 dbSNP
rs975895755 431 dbSNP
rs923214582 436 dbSNP
rs1337720806 445 dbSNP
rs1302798928 452 dbSNP
rs758470732 455 dbSNP
rs761048454 456 dbSNP
rs929478243 457 dbSNP
rs1474723071 460 dbSNP
rs1389532811 465 dbSNP
rs376324020 478 dbSNP
rs890217127 484 dbSNP
rs1170511077 486 dbSNP
rs1379396279 487 dbSNP
rs943100716 487 dbSNP
rs1199647126 488 dbSNP
rs146639575 492 dbSNP
rs776926567 492 dbSNP
rs779662046 492 dbSNP
rs1039176345 493 dbSNP
rs1180758313 494 dbSNP
rs557239445 495 dbSNP
rs1195982280 496 dbSNP
rs1197876785 496 dbSNP
rs1026352482 498 dbSNP
rs202011142 498 dbSNP
rs373960358 498 dbSNP
rs765424568 498 dbSNP
rs777401870 498 dbSNP
rs1160162513 499 dbSNP
rs879016634 499 dbSNP
rs199602253 500 dbSNP
rs1331127756 501 dbSNP
rs1378063549 501 dbSNP
rs200361238 501 dbSNP
rs1344830533 502 dbSNP
rs1173743256 503 dbSNP
rs1464438782 503 dbSNP
rs201472247 503 dbSNP
rs1328367514 504 dbSNP
rs1372095400 505 dbSNP
rs1376001610 505 dbSNP
rs1180700793 506 dbSNP
rs1440857023 507 dbSNP
rs796286916 508 dbSNP
rs1491356209 509 dbSNP
rs1224934902 510 dbSNP
rs1491093036 510 dbSNP
rs571445307 511 dbSNP
rs77903511 511 dbSNP
rs893503724 511 dbSNP
rs1241810450 512 dbSNP
rs1353947412 514 dbSNP
rs1308132069 518 dbSNP
rs113519837 522 dbSNP
rs1307344349 524 dbSNP
rs1328033811 525 dbSNP
rs1206374002 528 dbSNP
rs1020912698 534 dbSNP
rs1274849133 539 dbSNP
rs902394767 545 dbSNP
rs1400095350 556 dbSNP
rs1160508030 563 dbSNP
rs1042489 572 dbSNP
rs1379911844 580 dbSNP
rs1157140141 583 dbSNP
rs564831547 588 dbSNP
rs144790144 591 dbSNP
rs755735160 594 dbSNP
rs1369986996 630 dbSNP
rs990560274 631 dbSNP
rs1441795932 641 dbSNP
rs1255382125 648 dbSNP
rs1212377071 676 dbSNP
rs779690467 677 dbSNP
rs1488370927 680 dbSNP
rs1284852327 683 dbSNP
rs748880179 689 dbSNP
rs1013030310 690 dbSNP
rs777306171 693 dbSNP
rs758812176 698 dbSNP
rs1045868477 701 dbSNP
rs1300660150 706 dbSNP
rs1400674329 709 dbSNP
rs1167313413 717 dbSNP
rs963449326 717 dbSNP
rs1407330006 718 dbSNP
rs907503797 722 dbSNP
rs1163602155 728 dbSNP
rs138703176 737 dbSNP
rs1415578401 738 dbSNP
rs1405114121 743 dbSNP
rs1477829272 746 dbSNP
rs1261874635 751 dbSNP
rs542205905 753 dbSNP
rs1053538596 755 dbSNP
rs1213151279 757 dbSNP
rs893108510 761 dbSNP
rs762447826 783 dbSNP
rs1012093533 785 dbSNP
rs919517164 792 dbSNP
rs1356782403 793 dbSNP
rs79824097 794 dbSNP
rs900576494 795 dbSNP
rs997387693 798 dbSNP
rs1349263111 801 dbSNP
rs1268517653 809 dbSNP
rs191250920 810 dbSNP
rs1350657785 811 dbSNP
rs1323222462 819 dbSNP
rs1460718361 822 dbSNP
rs1384284448 832 dbSNP
rs1466098126 841 dbSNP
rs1184224577 850 dbSNP
rs912086476 850 dbSNP
rs1478762406 855 dbSNP
rs950616764 862 dbSNP
rs983356888 864 dbSNP
rs17878624 865 dbSNP
rs914973884 867 dbSNP
rs1365634434 868 dbSNP
rs946408509 872 dbSNP
rs963096671 873 dbSNP
rs902447228 891 dbSNP
rs1368473801 899 dbSNP
rs1346750299 900 dbSNP
rs1431123922 908 dbSNP
rs1368454595 910 dbSNP
rs1003483061 923 dbSNP
rs1406337098 925 dbSNP
rs990876839 933 dbSNP
rs181761491 934 dbSNP
rs1168304776 937 dbSNP
rs533200033 944 dbSNP
rs895013059 945 dbSNP
rs949137157 949 dbSNP
rs1239677187 954 dbSNP
rs981576831 955 dbSNP
rs928772680 956 dbSNP
rs1231659723 962 dbSNP
rs771381579 963 dbSNP
rs1312780059 968 dbSNP
rs540147173 974 dbSNP
rs150652785 975 dbSNP
rs377708686 980 dbSNP
rs947440223 985 dbSNP
rs1026250789 987 dbSNP
rs950701086 989 dbSNP
rs987713248 993 dbSNP
rs1039441081 995 dbSNP
rs912140353 997 dbSNP
rs1470759105 999 dbSNP
rs1311725993 1000 dbSNP
rs776591534 1002 dbSNP
rs2856269 1003 dbSNP
rs1381778918 1011 dbSNP
rs1158939384 1017 dbSNP
rs997564367 1018 dbSNP
rs1442446145 1020 dbSNP
rs1184999525 1022 dbSNP
rs1257479941 1023 dbSNP
rs1030180514 1026 dbSNP
rs1385346862 1027 dbSNP
rs886248212 1028 dbSNP
rs548543992 1029 dbSNP
rs1469122100 1038 dbSNP
rs1005104267 1039 dbSNP
rs1489344555 1044 dbSNP
rs1286934593 1053 dbSNP
rs915007427 1054 dbSNP
rs1016207767 1056 dbSNP
rs568529001 1064 dbSNP
rs17878377 1070 dbSNP
rs946433657 1071 dbSNP
rs1304622548 1073 dbSNP
rs17885994 1082 dbSNP
rs769764086 1084 dbSNP
rs1382660186 1085 dbSNP
rs191137126 1086 dbSNP
rs1361915385 1087 dbSNP
rs1298360982 1094 dbSNP
rs1452647167 1095 dbSNP
rs775843990 1096 dbSNP
rs1167308716 1097 dbSNP
rs1424828595 1098 dbSNP
rs1417755913 1100 dbSNP
rs573416645 1101 dbSNP
rs895024376 1109 dbSNP
rs138794504 1110 dbSNP
rs1204719700 1118 dbSNP
rs947921147 1120 dbSNP
rs1038581876 1132 dbSNP
rs928827133 1136 dbSNP
rs995355347 1143 dbSNP
rs1231385964 1149 dbSNP
rs1341792735 1151 dbSNP
rs1026344329 1158 dbSNP
rs886476628 1159 dbSNP
rs956256058 1167 dbSNP
rs989372038 1168 dbSNP
rs914864462 1174 dbSNP
rs1359423782 1179 dbSNP
rs947626750 1181 dbSNP
rs1218081983 1194 dbSNP
rs551857923 1195 dbSNP
rs764023319 1198 dbSNP
rs553301725 1199 dbSNP
rs1394207548 1205 dbSNP
rs567125434 1207 dbSNP
rs1019159702 1214 dbSNP
rs111816792 1224 dbSNP
rs751746692 1235 dbSNP
rs17885394 1236 dbSNP
rs1269724351 1238 dbSNP
rs1388854151 1239 dbSNP
rs1427331962 1243 dbSNP
rs1192011930 1244 dbSNP
rs1468701875 1247 dbSNP
rs542525186 1249 dbSNP
rs923680925 1250 dbSNP
rs1402217355 1251 dbSNP
rs1251885786 1264 dbSNP
rs1051870530 1268 dbSNP
rs1226041794 1272 dbSNP
rs149352631 1273 dbSNP
rs886507243 1278 dbSNP
rs373191333 1280 dbSNP
rs1004751449 1281 dbSNP
rs1370647991 1287 dbSNP
rs916514584 1288 dbSNP
rs1037935807 1295 dbSNP
rs899082801 1296 dbSNP
rs1325849029 1297 dbSNP
rs1012544221 1299 dbSNP
rs575734434 1304 dbSNP
rs1362926022 1306 dbSNP
rs947942038 1309 dbSNP
rs761865439 1311 dbSNP
rs970344304 1313 dbSNP
rs1236327211 1316 dbSNP
rs898351459 1321 dbSNP
rs1003144497 1322 dbSNP
rs1198999230 1328 dbSNP
rs1030738120 1332 dbSNP
rs537946622 1333 dbSNP
rs1191510402 1335 dbSNP
rs558271974 1337 dbSNP
rs1047842684 1340 dbSNP
rs956652269 1342 dbSNP
rs767505222 1343 dbSNP
rs1336831503 1355 dbSNP
rs1257262788 1362 dbSNP
rs1234443373 1364 dbSNP
rs2661694 1374 dbSNP
rs900480183 1375 dbSNP
rs1242753439 1378 dbSNP
rs996857526 1389 dbSNP
rs1022535363 1390 dbSNP
rs969008020 1400 dbSNP
rs1404385056 1409 dbSNP
rs1303479246 1411 dbSNP
rs1434228718 1412 dbSNP
rs1194766408 1413 dbSNP
rs968658199 1416 dbSNP
rs540375331 1426 dbSNP
rs1364195389 1429 dbSNP
rs183312799 1442 dbSNP
rs1435981647 1454 dbSNP
rs1258225767 1461 dbSNP
rs1210970387 1467 dbSNP
rs1030763124 1469 dbSNP
rs1277681178 1482 dbSNP
rs186938477 1494 dbSNP
rs1351803887 1495 dbSNP
rs1279363154 1515 dbSNP
rs542549013 1516 dbSNP
rs991842254 1520 dbSNP
rs916256554 1523 dbSNP
rs1486385100 1524 dbSNP
rs947733911 1525 dbSNP
rs974432097 1526 dbSNP
rs919852507 1530 dbSNP
rs1301836172 1546 dbSNP
rs1420558392 1549 dbSNP
rs1384581259 1550 dbSNP
rs370504799 1552 dbSNP
rs1051757370 1561 dbSNP
rs1468467133 1566 dbSNP
rs1231156897 1568 dbSNP
rs907989868 1569 dbSNP
rs1330101482 1573 dbSNP
rs1254821882 1578 dbSNP
rs1208276818 1579 dbSNP
rs1266665503 1592 dbSNP
rs760290396 1593 dbSNP
rs1203751555 1607 dbSNP
rs562122968 1610 dbSNP
rs17884909 1611 dbSNP
rs1214911037 1615 dbSNP
rs531384589 1616 dbSNP
rs1267231539 1619 dbSNP
rs1432157819 1620 dbSNP
rs907980920 1622 dbSNP
rs1037547821 1625 dbSNP
rs1431619815 1626 dbSNP
rs898964520 1632 dbSNP
rs753566198 1633 dbSNP
rs575572774 1639 dbSNP
rs1316570116 1652 dbSNP
rs17883788 1668 dbSNP
rs17879923 1669 dbSNP
rs904070308 1671 dbSNP
rs1195174264 1673 dbSNP
rs1475495704 1678 dbSNP
rs140212651 1682 dbSNP
rs764467639 1683 dbSNP
rs1453643303 1687 dbSNP
rs1030623659 1688 dbSNP
rs17879624 1691 dbSNP
rs547179362 1692 dbSNP
rs1021809768 1708 dbSNP
rs969313642 1709 dbSNP
rs533509901 1711 dbSNP
rs1268572377 1724 dbSNP
rs1438920610 1729 dbSNP
rs1372854025 1732 dbSNP
rs1042541 1736 dbSNP
rs1439946658 1739 dbSNP
rs1392200542 1742 dbSNP
rs954938046 1743 dbSNP
rs1172518621 1752 dbSNP
rs1409972857 1753 dbSNP
rs536131529 1757 dbSNP
rs907832091 1758 dbSNP
rs973726375 1769 dbSNP
rs1253278961 1774 dbSNP
rs1265425603 1776 dbSNP
rs1487797861 1777 dbSNP
rs549741429 1782 dbSNP
rs569264880 1783 dbSNP
rs1205843024 1786 dbSNP
rs1437277400 1789 dbSNP
rs1271003255 1791 dbSNP
rs1221067086 1793 dbSNP
rs1042542 1794 dbSNP
rs920672627 1795 dbSNP
rs1233277915 1796 dbSNP
rs769970019 1799 dbSNP
rs947919270 1800 dbSNP
rs145698232 1801 dbSNP
rs1181074026 1806 dbSNP
rs1044869906 1807 dbSNP
rs1436113251 1807 dbSNP
rs17885897 1811 dbSNP
rs779969178 1816 dbSNP
rs749556101 1823 dbSNP
rs1178235573 1826 dbSNP
rs1470058345 1827 dbSNP
rs4789560 1828 dbSNP
rs1367611102 1829 dbSNP
rs1486073579 1851 dbSNP
rs1010676576 1853 dbSNP
rs1345409352 1854 dbSNP
rs1022489973 1856 dbSNP
rs553536085 1863 dbSNP
rs1308851702 1865 dbSNP
rs899573735 1877 dbSNP
rs1169531292 1883 dbSNP
rs1372516689 1885 dbSNP
rs1277758366 1889 dbSNP
rs548444908 1891 dbSNP
rs1375524057 1900 dbSNP
rs1311858992 1909 dbSNP
rs542510240 1915 dbSNP
rs761634424 1921 dbSNP
rs926757320 1923 dbSNP
rs1160255149 1924 dbSNP
rs1418929929 1929 dbSNP
rs896691159 1930 dbSNP
rs1029124721 1934 dbSNP
rs562486606 1935 dbSNP
rs1185958851 1940 dbSNP
rs1486954002 1947 dbSNP
rs1261598860 1960 dbSNP
rs1216218127 1962 dbSNP
rs1306474014 1963 dbSNP
rs17882360 1968 dbSNP
rs1396760545 1974 dbSNP
rs1014944217 1975 dbSNP
rs995595893 1975 dbSNP
rs59214380 1978 dbSNP
rs951035528 1979 dbSNP
rs982695283 1988 dbSNP
rs1289147660 1989 dbSNP
rs912474162 1990 dbSNP
rs1343810502 2000 dbSNP
rs1167667561 2003 dbSNP
rs537041613 2004 dbSNP
rs1417825207 2008 dbSNP
rs973415650 2008 dbSNP
rs1162873582 2009 dbSNP
rs1430432939 2010 dbSNP
rs920712159 2018 dbSNP
rs1186148786 2026 dbSNP
rs948137080 2027 dbSNP
rs550209052 2030 dbSNP
rs980577156 2033 dbSNP
rs1248911846 2045 dbSNP
rs760497819 2049 dbSNP
rs1182045549 2050 dbSNP
rs879453340 2051 dbSNP
rs74532139 2058 dbSNP
rs1308763489 2063 dbSNP
rs11655530 2064 dbSNP
rs1255247369 2067 dbSNP
rs1421815150 2068 dbSNP
rs1195295875 2069 dbSNP
rs1390703293 2078 dbSNP
rs1429251582 2082 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uguccguaccCUCCAGUCCacu 5'
                    || || |||   
Target 5' ---------aGAAGUGAGGgag 3'
 		1 - 13
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uguccguacccuccaGUCCACu 5'
                         |||||| 
Target 5' -auucccgggcuuacCAGGUG- 3'
 		1 - 20
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 332.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000301633.4 | 3UTR | agaagugagggaggaaga
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000301633.4 | 3UTR | auucccgggcuuaccaggug
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000301633.4 | 3UTR | auucccgggcuuaccaggug
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.709 0.04 0.786 0.02 7 Click to see details
PRAD 0.329 0.04 0.315 0.05 28 Click to see details
BLCA 0.525 0.11 0.679 0.05 7 Click to see details
KICH 0.874 0.16 1.000 0.5 3 Click to see details
STAD 0.484 0.17 0.600 0.1 6 Click to see details
KIRC -0.509 0.19 -0.700 0.09 5 Click to see details
KIRP 0.246 0.22 0.182 0.29 12 Click to see details
THCA 0.028 0.43 0.003 0.49 48 Click to see details
LUSC -0.026 0.46 -0.127 0.31 18 Click to see details
UCEC -0.022 0.47 0.021 0.47 12 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
BRCA 0.004 0.49 0.055 0.43 14 Click to see details
104 hsa-miR-3622a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT052866 MRPL16 mitochondrial ribosomal protein L16 1 1
MIRT076712 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT080211 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT081397 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT107157 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT254070 BACH1 BTB domain and CNC homolog 1 2 2
MIRT409789 FOXO3 forkhead box O3 2 2
MIRT448680 MAPK9 mitogen-activated protein kinase 9 2 2
MIRT450207 ABHD15 abhydrolase domain containing 15 2 2
MIRT486622 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT489268 TTLL1 tubulin tyrosine ligase like 1 2 2
MIRT493118 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT494571 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497396 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT504901 CCDC86 coiled-coil domain containing 86 2 2
MIRT505193 USP46 ubiquitin specific peptidase 46 2 4
MIRT506524 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT508163 ABCC5 ATP binding cassette subfamily C member 5 2 8
MIRT508546 PARVG parvin gamma 2 4
MIRT509851 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT510089 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 8
MIRT512095 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT515382 RPL7 ribosomal protein L7 2 2
MIRT519177 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519965 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT522293 NKAP NFKB activating protein 2 2
MIRT523161 HMGB2 high mobility group box 2 2 4
MIRT525315 FANCA Fanconi anemia complementation group A 2 2
MIRT528195 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT532886 ZNF451 zinc finger protein 451 2 2
MIRT538210 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539498 ACTN4 actinin alpha 4 2 2
MIRT554602 RRAGC Ras related GTP binding C 2 2
MIRT562446 DCTN6 dynactin subunit 6 2 2
MIRT562749 AOC3 amine oxidase, copper containing 3 2 2
MIRT565800 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT565839 SCML2 Scm polycomb group protein like 2 2 2
MIRT566073 RCC2 regulator of chromosome condensation 2 2 2
MIRT566105 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT572408 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT576199 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576314 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576652 Mill2 MHC I like leukocyte 2 1 1
MIRT576860 Socs6 suppressor of cytokine signaling 6 2 2
MIRT606820 BICD2 BICD cargo adaptor 2 2 2
MIRT610739 NUDT16 nudix hydrolase 16 2 4
MIRT614799 RORA RAR related orphan receptor A 2 2
MIRT619007 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 2
MIRT619421 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT620406 MYO1H myosin IH 2 2
MIRT624870 ABHD13 abhydrolase domain containing 13 2 2
MIRT633528 ZFP30 ZFP30 zinc finger protein 2 2
MIRT633928 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT636612 CLIC5 chloride intracellular channel 5 2 2
MIRT640617 MIOX myo-inositol oxygenase 2 2
MIRT642606 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT644625 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT655114 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT658977 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT661496 CHMP1B charged multivesicular body protein 1B 2 2
MIRT662997 TMEM59 transmembrane protein 59 2 2
MIRT663076 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT665406 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT666107 SSR1 signal sequence receptor subunit 1 2 2
MIRT669563 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT670071 ZNF783 zinc finger family member 783 2 2
MIRT671193 ZNF891 zinc finger protein 891 2 2
MIRT675362 KLHL26 kelch like family member 26 2 2
MIRT678858 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT679444 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT684164 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT684544 ZNF460 zinc finger protein 460 2 2
MIRT684675 SLC2A11 solute carrier family 2 member 11 2 2
MIRT684972 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT686007 NEK4 NIMA related kinase 4 2 2
MIRT687759 KIAA1328 KIAA1328 2 2
MIRT688962 ATXN3 ataxin 3 2 2
MIRT689410 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT690002 MMP17 matrix metallopeptidase 17 2 2
MIRT690166 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690203 C5orf45 MRN complex interacting protein 2 2
MIRT690478 ZNF33A zinc finger protein 33A 2 2
MIRT690567 MICA MHC class I polypeptide-related sequence A 2 2
MIRT692161 C10orf111 chromosome 10 open reading frame 111 2 2
MIRT693431 PLGLB2 plasminogen-like B2 2 2
MIRT693548 ZNF708 zinc finger protein 708 2 2
MIRT693698 PLGLB1 plasminogen-like B1 2 2
MIRT695007 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT698526 TFRC transferrin receptor 2 2
MIRT699575 SIKE1 suppressor of IKBKE 1 2 2
MIRT703447 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704398 CTSS cathepsin S 2 2
MIRT704486 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT709511 IGF2 insulin like growth factor 2 2 2
MIRT709823 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT710860 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT711894 INSIG2 insulin induced gene 2 2 2
MIRT713797 CPLX2 complexin 2 2 2
MIRT718801 C1GALT1C1 C1GALT1 specific chaperone 1 2 2
MIRT719502 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719723 PDE6B phosphodiesterase 6B 2 2
MIRT722205 URM1 ubiquitin related modifier 1 2 2
MIRT723524 CLPTM1L CLPTM1 like 2 2
MIRT725473 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3622a Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-mir-3622a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-3622a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622a-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3622a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622a-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-3622a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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