pre-miRNA Information
pre-miRNA hsa-mir-3678   
Genomic Coordinates chr17: 75406069 - 75406162
Description Homo sapiens miR-3678 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3678-3p
Sequence 69| CUGCAGAGUUUGUACGGACCGG |90
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs988363493 1 dbSNP
rs753118178 5 dbSNP
rs1424776090 14 dbSNP
rs1475188526 15 dbSNP
rs1163369708 17 dbSNP
rs1174219930 19 dbSNP
rs915488824 20 dbSNP
rs1273558782 21 dbSNP
rs755095016 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GAS1   
Synonyms -
Description growth arrest specific 1
Transcript NM_002048   
Expression
Putative miRNA Targets on GAS1
3'UTR of GAS1
(miRNA target sites are highlighted)
>GAS1|NM_002048|3'UTR
   1 CCCTCGCGCCCCCCGCCGTTGGCTGCGGGAGAGCCCGCGTCCCACTCCCGTGCTCGCCTCGACCCCGCGCCGGGCACCTG
  81 TGGCTTGGGACAGATAGAAGGGATGGTTGGGGATACTTCCCAAAACTTTTTCCAAGTCAACTTGGTGTAGCCGGTTCCCC
 161 GGCCACGACTCTGGGCACTTCCCCTGAAGCTCCTCTCCGGAGCTTGACTTCTTGGACCTCCTCCCCCGCCCCAATTCCAA
 241 GCTCCAGAAACTCCCAACTCGTCTGCCGTCCAGAAAGCTAGCTGCAGTGTTCAGGACGTCCGGGAGGAAGCAAGCATGTG
 321 GGGGACAGAACAGTAGTCCTGGACTCGAAAGGGAAGGTGCTGACCAGTGGGGCCTTAGCAATTTGAAGGGTTGGGAAGGA
 401 GGAATTATATTTGCAAAGGGGCTGTCTATTAGCATATTTCCTTTGAGGGGGCAAAAAAAAGTGCCAGTATCGACTTTTAC
 481 AGATTGTGGCCAGTGAGGATATTATAATCCTATGTAAACAGAAAAGTCCCACTTACCGATTCATTCTTTCACTGTTTGTA
 561 TCTGCGCCCAGAATTCTCAGTGACGTGGGGGTGAGGGTGGGTGGCGATTGCCTTAGAGGGAACCCCTAAATTGGTTTTGG
 641 ATAAGTTTGAGCCCTTGACCTTAATTTCATTGCTACCACTCTGATCTCTTAGCACATTTCTTAGGATTAAGGGTCCAAAA
 721 ATGCTGATCTAAGGGGTTGCCATGGTGTTGAACAATGCAACTTTTTATTTAAAAAAGCTCTGCACTGCCATGTATGAAAG
 801 TCTCTTTATGATGTTTGTTTTTTTGTCATTTTTGTTCTTTACATCAAGAAATTTTATGTTTAAATATGCGGAGAATGTAT
 881 ATTGCCTCTGCTCCTATCAGGGTTGCTAAACCCTGGTACATCGTATATAAAATGTATTAAAACTGGGGTTTGTTACCAGT
 961 TGCTGTACTTTGTATATAGAATTTTTATAAATTGTATGCTTCAGAAATAATTTATTTTTAAAAAGAAATTAAAAGTTTTA
1041 AACTCACATCCATATTACACCTTTCCCCCCTGAAATGTATAGAATCCATTTGTCATCAGGAATCAAAACCCACAGTCCAT
1121 TGTGAAGTGTGCTATATTTAGAACAGTCTTAAAATGTACAGTGTATTTTATAGAATTGAAGTTAACATTCTTATTTTCAA
1201 GAGAATTTATGGACGTTGTAGAAATGTACAAATGCATTTCCAAACTGCCTTAAACGTTGTATTTTTATAGACATGTTTTT
1281 TAAAAATCCTAAGTTTTTAAATAACTATGGATTTGTGTATTTTTTTTGGTTATTTGTTTTATTAAAACATGTACATCAGT
1361 AAAGAGTTTTAAACAATGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggccAGGCAUGUUUGAGACGUc 5'
              |::  | ||:||||||| 
Target 5' tttaTTTAAAAAAGCTCTGCAc 3'
764 - 785 154.00 -11.50
2
miRNA  3' ggccagGCAUGU--UUGAGACGuc 5'
                :|||:|  : ||||||  
Target 5' ggagaaTGTATATTGCCTCTGCtc 3'
870 - 893 130.00 -12.40
3
miRNA  3' ggcCAGGCAUGUUUGA--GACGUc 5'
             ||||  | ||:||  ||||| 
Target 5' gccGTCCAGA-AAGCTAGCTGCAg 3'
265 - 287 122.00 -19.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28871877 8 COSMIC
COSN26679934 48 COSMIC
COSN20408834 418 COSMIC
COSN22880532 452 COSMIC
COSN32065370 546 COSMIC
COSN20272124 781 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1161516115 4 dbSNP
rs911173078 8 dbSNP
rs1042475322 9 dbSNP
rs1215420321 9 dbSNP
rs758991804 10 dbSNP
rs1030618715 11 dbSNP
rs1216300915 12 dbSNP
rs999189343 13 dbSNP
rs1295925770 14 dbSNP
rs896542688 15 dbSNP
rs577042502 22 dbSNP
rs890186244 25 dbSNP
rs1030067541 26 dbSNP
rs996342470 27 dbSNP
rs1057381059 28 dbSNP
rs1329369276 33 dbSNP
rs1467299712 34 dbSNP
rs937151529 36 dbSNP
rs1175539412 37 dbSNP
rs1431668147 39 dbSNP
rs1422735918 40 dbSNP
rs1465048363 41 dbSNP
rs773859589 46 dbSNP
rs984030891 49 dbSNP
rs1040279531 51 dbSNP
rs941614019 60 dbSNP
rs1321383986 61 dbSNP
rs888739789 63 dbSNP
rs553718800 64 dbSNP
rs373416818 65 dbSNP
rs929988439 66 dbSNP
rs1199186404 70 dbSNP
rs1267172698 74 dbSNP
rs1019321596 83 dbSNP
rs927962892 97 dbSNP
rs982167978 100 dbSNP
rs986037988 107 dbSNP
rs1418978620 110 dbSNP
rs1176316195 112 dbSNP
rs533598702 114 dbSNP
rs369281409 115 dbSNP
rs1170499277 116 dbSNP
rs1233434631 118 dbSNP
rs554576071 121 dbSNP
rs1404522657 122 dbSNP
rs1310251535 125 dbSNP
rs989756792 127 dbSNP
rs537612689 129 dbSNP
rs1343401095 133 dbSNP
rs902553357 135 dbSNP
rs1020926301 138 dbSNP
rs533529341 142 dbSNP
rs977715940 149 dbSNP
rs1276106648 152 dbSNP
rs1342486215 154 dbSNP
rs1221246997 157 dbSNP
rs551979865 160 dbSNP
rs1307339667 165 dbSNP
rs1393268405 174 dbSNP
rs3834100 177 dbSNP
rs1302812184 178 dbSNP
rs1055182356 184 dbSNP
rs954350524 187 dbSNP
rs1446384865 188 dbSNP
rs1361273640 189 dbSNP
rs1029973512 195 dbSNP
rs995901205 197 dbSNP
rs533235078 198 dbSNP
rs112023786 208 dbSNP
rs201609550 208 dbSNP
rs547769424 211 dbSNP
rs113149366 214 dbSNP
rs1156433667 216 dbSNP
rs1006156477 217 dbSNP
rs1420375965 218 dbSNP
rs1408023198 223 dbSNP
rs918483883 224 dbSNP
rs1365274067 226 dbSNP
rs1312468727 227 dbSNP
rs1210829139 228 dbSNP
rs1357951373 228 dbSNP
rs562368907 230 dbSNP
rs1445812659 238 dbSNP
rs1211114789 246 dbSNP
rs943681973 254 dbSNP
rs144778148 256 dbSNP
rs954379262 260 dbSNP
rs531913383 261 dbSNP
rs1163668973 263 dbSNP
rs1383945656 265 dbSNP
rs930228630 266 dbSNP
rs979543096 267 dbSNP
rs906491964 268 dbSNP
rs760140563 271 dbSNP
rs569121100 275 dbSNP
rs1279401150 276 dbSNP
rs1348981234 281 dbSNP
rs948157281 293 dbSNP
rs190819404 297 dbSNP
rs1241407400 298 dbSNP
rs1317601741 309 dbSNP
rs1201887499 313 dbSNP
rs989312093 320 dbSNP
rs1312024427 327 dbSNP
rs1021125892 345 dbSNP
rs546456015 346 dbSNP
rs1181344674 355 dbSNP
rs1014013113 358 dbSNP
rs1471490102 363 dbSNP
rs369127758 367 dbSNP
rs1412643934 370 dbSNP
rs936538964 371 dbSNP
rs1034220563 374 dbSNP
rs1396321078 389 dbSNP
rs1327773904 390 dbSNP
rs1348183685 392 dbSNP
rs1412094561 393 dbSNP
rs1289334126 394 dbSNP
rs1323500902 396 dbSNP
rs1002275565 404 dbSNP
rs1257896081 407 dbSNP
rs879117088 408 dbSNP
rs1345801489 411 dbSNP
rs977955913 416 dbSNP
rs1399833599 420 dbSNP
rs553588257 422 dbSNP
rs540185157 423 dbSNP
rs1358968999 428 dbSNP
rs574365400 430 dbSNP
rs1184112820 432 dbSNP
rs887830077 434 dbSNP
rs773599089 436 dbSNP
rs772575982 444 dbSNP
rs1345279947 447 dbSNP
rs1379231762 460 dbSNP
rs1466120986 461 dbSNP
rs995300177 461 dbSNP
rs1368349172 464 dbSNP
rs964474156 467 dbSNP
rs748593993 469 dbSNP
rs548859219 472 dbSNP
rs1385657731 474 dbSNP
rs1036940825 481 dbSNP
rs1005982395 492 dbSNP
rs1332122629 493 dbSNP
rs1226813793 501 dbSNP
rs554818172 505 dbSNP
rs1344626300 507 dbSNP
rs867264405 509 dbSNP
rs1206106688 510 dbSNP
rs912209981 511 dbSNP
rs994385637 518 dbSNP
rs1260690427 524 dbSNP
rs1189188008 526 dbSNP
rs906816276 528 dbSNP
rs1207138531 534 dbSNP
rs932433312 535 dbSNP
rs1191899916 536 dbSNP
rs537724084 536 dbSNP
rs769235488 542 dbSNP
rs925012043 549 dbSNP
rs979574443 552 dbSNP
rs774813743 554 dbSNP
rs1295603619 560 dbSNP
rs1456724650 560 dbSNP
rs868352783 562 dbSNP
rs895220330 565 dbSNP
rs1219520441 566 dbSNP
rs1337009184 584 dbSNP
rs529397220 587 dbSNP
rs1229152758 592 dbSNP
rs914190117 595 dbSNP
rs1320095972 597 dbSNP
rs936777652 600 dbSNP
rs922653086 601 dbSNP
rs1302299750 605 dbSNP
rs1298104170 606 dbSNP
rs1245742670 610 dbSNP
rs775652237 619 dbSNP
rs1384248428 621 dbSNP
rs1421648269 622 dbSNP
rs1167396690 623 dbSNP
rs1042209901 633 dbSNP
rs961015858 641 dbSNP
rs1453743355 651 dbSNP
rs1383111350 652 dbSNP
rs544471971 653 dbSNP
rs1391399468 664 dbSNP
rs1435939479 676 dbSNP
rs1033696936 679 dbSNP
rs1377300500 683 dbSNP
rs1230218176 685 dbSNP
rs923204099 698 dbSNP
rs187464708 700 dbSNP
rs964700734 701 dbSNP
rs1027705987 709 dbSNP
rs995370798 711 dbSNP
rs1395986051 713 dbSNP
rs538494050 726 dbSNP
rs1236352327 733 dbSNP
rs908894972 736 dbSNP
rs896986407 744 dbSNP
rs1165573019 755 dbSNP
rs570880766 757 dbSNP
rs950453435 763 dbSNP
rs1025808319 769 dbSNP
rs1157339209 777 dbSNP
rs1414881980 780 dbSNP
rs1195147101 782 dbSNP
rs1428866985 783 dbSNP
rs1175856510 791 dbSNP
rs1357489679 792 dbSNP
rs1450543789 793 dbSNP
rs1267003728 794 dbSNP
rs994379295 799 dbSNP
rs1008132092 804 dbSNP
rs891010121 810 dbSNP
rs1343757841 811 dbSNP
rs1049425809 813 dbSNP
rs970952301 818 dbSNP
rs1469900212 821 dbSNP
rs1402920321 823 dbSNP
rs1309927073 824 dbSNP
rs575558350 825 dbSNP
rs75335205 829 dbSNP
rs903622642 842 dbSNP
rs1043447451 848 dbSNP
rs945588803 859 dbSNP
rs1253591247 862 dbSNP
rs546166956 869 dbSNP
rs1191119606 872 dbSNP
rs1423603655 879 dbSNP
rs527650950 884 dbSNP
rs1176817776 885 dbSNP
rs1012515248 886 dbSNP
rs1311950562 889 dbSNP
rs749540054 891 dbSNP
rs992850630 893 dbSNP
rs1438176993 902 dbSNP
rs939636971 906 dbSNP
rs1220486288 912 dbSNP
rs926828301 913 dbSNP
rs1326065220 919 dbSNP
rs895116406 920 dbSNP
rs1277298746 925 dbSNP
rs952018200 932 dbSNP
rs1053795536 947 dbSNP
rs1462324620 956 dbSNP
rs1479265562 957 dbSNP
rs1000871454 965 dbSNP
rs902639876 968 dbSNP
rs1447953448 972 dbSNP
rs961226660 974 dbSNP
rs1371324925 976 dbSNP
rs182783172 989 dbSNP
rs1042184050 991 dbSNP
rs1322605379 993 dbSNP
rs933183510 996 dbSNP
rs923141683 1005 dbSNP
rs1376813568 1018 dbSNP
rs1172007932 1019 dbSNP
rs1039339072 1021 dbSNP
rs149438850 1025 dbSNP
rs891048190 1031 dbSNP
rs1028625146 1035 dbSNP
rs1178181040 1036 dbSNP
rs943300944 1057 dbSNP
rs996503424 1060 dbSNP
rs34813745 1065 dbSNP
rs903529198 1065 dbSNP
rs1453881915 1068 dbSNP
rs1253341195 1070 dbSNP
rs1043481977 1072 dbSNP
rs1463604019 1086 dbSNP
rs1196848067 1088 dbSNP
rs1391039571 1092 dbSNP
rs1483132042 1094 dbSNP
rs1162485668 1095 dbSNP
rs548631933 1096 dbSNP
rs1407082922 1097 dbSNP
rs11795098 1100 dbSNP
rs1326507616 1106 dbSNP
rs746159929 1111 dbSNP
rs1432293157 1112 dbSNP
rs1236939959 1114 dbSNP
rs1326695053 1119 dbSNP
rs1243580475 1122 dbSNP
rs7869285 1123 dbSNP
rs1358903563 1130 dbSNP
rs1056636083 1134 dbSNP
rs563221386 1142 dbSNP
rs1463894916 1147 dbSNP
rs972885576 1156 dbSNP
rs971276472 1158 dbSNP
rs1248699902 1159 dbSNP
rs1025161090 1162 dbSNP
rs1385823688 1169 dbSNP
rs1185685858 1172 dbSNP
rs14441 1174 dbSNP
rs1239368049 1175 dbSNP
rs991441239 1185 dbSNP
rs1165321736 1189 dbSNP
rs111308204 1198 dbSNP
rs1411193629 1203 dbSNP
rs1455546133 1204 dbSNP
rs1238861261 1215 dbSNP
rs1385030423 1233 dbSNP
rs1333430460 1241 dbSNP
rs1330846832 1249 dbSNP
rs777698497 1250 dbSNP
rs758318639 1251 dbSNP
rs780359012 1255 dbSNP
rs1436349401 1268 dbSNP
rs1371153571 1273 dbSNP
rs902592704 1274 dbSNP
rs1415806413 1275 dbSNP
rs1395962183 1277 dbSNP
rs1327766253 1278 dbSNP
rs920580189 1282 dbSNP
rs930654142 1282 dbSNP
rs972029299 1286 dbSNP
rs1468684883 1287 dbSNP
rs1443177951 1288 dbSNP
rs1020965629 1289 dbSNP
rs1250768197 1297 dbSNP
rs962140857 1302 dbSNP
rs1184246586 1307 dbSNP
rs1364243070 1315 dbSNP
rs997573662 1317 dbSNP
rs901633551 1319 dbSNP
rs1442409069 1320 dbSNP
rs766902654 1328 dbSNP
rs955376596 1328 dbSNP
rs1256019446 1329 dbSNP
rs1213523219 1332 dbSNP
rs1411992882 1333 dbSNP
rs1038872420 1339 dbSNP
rs943270312 1342 dbSNP
rs1276660976 1348 dbSNP
rs1348928757 1353 dbSNP
rs748088409 1356 dbSNP
rs1204680485 1366 dbSNP
rs996702848 1367 dbSNP
rs1486192828 1374 dbSNP
rs1280631005 1376 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2619.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2619.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000298743.7 | 3UTR | CAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000298743.7 | 3UTR | CAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000298743.7 | 3UTR | AACAAUGCAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000298743.7 | 3UTR | AAUGCAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000298743.7 | 3UTR | GUUGAACAAUGCAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000298743.7 | 3UTR | CAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000298743.7 | 3UTR | CAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000298743.7 | 3UTR | CAACUUUUUAUUUAAAAAAGCUCUGCACUGCCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.427 0.1 0.445 0.09 11 Click to see details
LIHC -0.334 0.19 -0.400 0.14 9 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
LUSC 0.62 0.19 0.800 0.1 4 Click to see details
86 hsa-miR-3678-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074327 TNRC6A trinucleotide repeat containing 6A 2 10
MIRT107705 CLTA clathrin light chain A 2 2
MIRT114113 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT155293 IFNAR2 interferon alpha and beta receptor subunit 2 2 4
MIRT159171 NRBP1 nuclear receptor binding protein 1 2 2
MIRT185795 ZNF678 zinc finger protein 678 2 2
MIRT282672 SYNM synemin 2 2
MIRT294386 ZNF264 zinc finger protein 264 2 2
MIRT295818 CHMP4B charged multivesicular body protein 4B 2 2
MIRT332777 CAPRIN1 cell cycle associated protein 1 2 4
MIRT334112 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT340971 IPO5 importin 5 2 2
MIRT354679 CDV3 CDV3 homolog 2 2
MIRT366662 PLP2 proteolipid protein 2 2 2
MIRT404272 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT447536 RNF165 ring finger protein 165 2 2
MIRT449139 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT451301 LGALS3BP galectin 3 binding protein 2 2
MIRT451488 FOPNL FGFR1OP N-terminal like 2 2
MIRT455198 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT459215 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT461764 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT463273 ZFX zinc finger protein, X-linked 2 2
MIRT464862 UBB ubiquitin B 2 8
MIRT464950 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT467378 SON SON DNA binding protein 2 4
MIRT469282 RHOA ras homolog family member A 2 2
MIRT470293 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT470639 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT477163 FABP3 fatty acid binding protein 3 2 2
MIRT477686 EFHD2 EF-hand domain family member D2 2 2
MIRT479725 CCNF cyclin F 2 2
MIRT481726 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT485673 CCDC64 BICD family like cargo adaptor 1 2 2
MIRT498280 PADI2 peptidyl arginine deiminase 2 2 2
MIRT499921 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT503616 SLC25A36 solute carrier family 25 member 36 2 4
MIRT506927 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507348 FAM129A family with sequence similarity 129 member A 2 6
MIRT508265 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT508284 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT509353 COPS8 COP9 signalosome subunit 8 2 2
MIRT510892 RAB1A RAB1A, member RAS oncogene family 2 4
MIRT511882 GAS1 growth arrest specific 1 2 6
MIRT511990 E2F1 E2F transcription factor 1 2 4
MIRT512239 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512392 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 4
MIRT514086 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT514358 UBBP4 ubiquitin B pseudogene 4 2 6
MIRT523149 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT525511 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT526333 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT529962 ZNF71 zinc finger protein 71 2 2
MIRT530337 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT530884 PHOX2A paired like homeobox 2a 2 2
MIRT533097 YOD1 YOD1 deubiquitinase 2 2
MIRT533250 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT534786 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT537917 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT547799 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT548714 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT555509 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555984 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT557942 FAM222B family with sequence similarity 222 member B 2 2
MIRT560830 ZNF786 zinc finger protein 786 2 2
MIRT562720 ZNF714 zinc finger protein 714 2 2
MIRT565337 TMEM104 transmembrane protein 104 2 2
MIRT614453 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT639474 SLC6A4 solute carrier family 6 member 4 2 2
MIRT644056 IQCE IQ motif containing E 2 2
MIRT651652 VWA1 von Willebrand factor A domain containing 1 2 2
MIRT651866 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT653490 SLC43A2 solute carrier family 43 member 2 2 2
MIRT657039 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT657985 GAN gigaxonin 2 2
MIRT672117 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT683583 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT688689 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT695375 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT696351 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT700614 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 2 2
MIRT703512 FKBP15 FK506 binding protein 15 2 2
MIRT705051 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705180 BTG1 BTG anti-proliferation factor 1 2 2
MIRT709409 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT721053 DCC DCC netrin 1 receptor 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3678-3p Platinum 23939 resistant tissue
hsa-miR-3678-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3678-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3678-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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