pre-miRNA Information
pre-miRNA hsa-mir-1303   
Genomic Coordinates chr5: 154685776 - 154685861
Synonyms MIRN1303, hsa-mir-1303, MIR1303
Description Homo sapiens miR-1303 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1303
Sequence 52| UUUAGAGACGGGGUCUUGCUCU |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 5 + 154685830 23291724, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs370437195 6 dbSNP
rs1195001383 7 dbSNP
rs546614687 8 dbSNP
rs762579883 9 dbSNP
rs766041486 10 dbSNP
rs751079975 12 dbSNP
rs888516744 13 dbSNP
rs566454487 14 dbSNP
rs766973220 15 dbSNP
rs1474274822 17 dbSNP
rs753222192 18 dbSNP
rs1230907999 19 dbSNP
rs756552638 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LAYN   
Synonyms -
Description layilin
Transcript NM_178834   
Expression
Putative miRNA Targets on LAYN
3'UTR of LAYN
(miRNA target sites are highlighted)
>LAYN|NM_178834|3'UTR
   1 GACATATAAAAAACTGAAACTGACAACAATGGAAAAGAAATGATAAGCAAAATCCTCTTATTTTCTATAAGGAAAATACA
  81 CAGAAGGTCTATGAACAAGCTTAGATCAGGTCCTGTGGATGAGCATGTGGTCCCCACGACCTCCTGTTGGACCCCCACGT
 161 TTTGGCTGTATCCTTTATCCCAGCCAGTCATCCAGCTCGACCTTATGAGAAGGTACCTTGCCCAGGTCTGGCACATAGTA
 241 GAGTCTCAATAAATGTCACTTGGTTGGTTGTATCTAACTTTTAAGGGACAGAGCTTTACCTGGCAGTGATAAAGATGGGC
 321 TGTGGAGCTTGGAAAACCACCTCTGTTTTCCTTGCTCTATACAGCAGCACATATTATCATACAGACAGAAAATCCAGAAT
 401 CTTTTCAAAGCCCACATATGGTAGCACAGGCTGGCCTGTGCATCGGCAATTCTCATATCTGTTTTTTTCAAAGAATAATA
 481 AAATCAAATAAAGAGCAGGAAACAGAGTGTTAGTCTGTGTCTACAGCCCTTCCTCTGCATGTGGCCACAGGGGACCTTTT
 561 TTTGTTTCTCCTGACATCCAGACTTGGAAATATCTAACTACTTGCAAAACTAAAAATGAGGCCAGGCGCAGTGGCTGACG
 641 CCTGTAATCCCAGAACCTTGGGAGACCAAGATTGGAGGATAGCTTGAGTTCAGGAGTTCCAGACCTTCCTGGGCAAAATA
 721 GTGAGACTCTGACTCTACAAAAAATTTAAAAATTAGCAGGGCATGGTGGCATGCGCCTGCAGTCCCAGCTACTCAGGAGG
 801 CCGAGGTGGGGGAATTGCTTGAGCCCAGGAGGTTGAGGCTGCAGTGAGCTAGGATCACGCCACTGCTCTCCTGCGTGGGC
 881 AACAGAATGAGACCCTGTCTCTAAACAAAAATATTTTTTAAAGAAACTAAAAATGAAATTTGAGTCTCAGCTTCTAGGCT
 961 TATGTACTCCCATCCCTGATACTACACGTTGTTCTGTTTGCATGTTTGTTACTGCAGCATCAACATAACATGACTAATAA
1041 TGATGACAGTTCTACCTTTTGTTGACAGACCTCATTGTTTCAATTGTGTTTGGCCTCAAATTCAGAGAAAAGTTTCTCAG
1121 CCCAGCATCAATCATATACACATTGGAGGTCTGAAAGCCATTATTTAAATCACCAGCAATTTCCCTCAATCAGCTTCATA
1201 ATCTCATATTTTAACCTTTCCTCATATGTCTTATTTTTTAATAGCTCAGCAACTTTGCTTCACATATGGAGCCCCAACCT
1281 CTAGAGT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCGUUCUGGGGCAGAGAUUu 5'
            | ::||||||:|||||||| 
Target 5' agAATGAGACCCTGTCTCTAAa 3'
884 - 905 180.00 -30.70
2
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            ||::||||:|:| |||||  
Target 5' atAGTGAGACTCTGACTCTAca 3'
718 - 739 132.00 -17.90
3
miRNA  3' ucUCGUUCUGGGG----CAGAGAUuu 5'
            ||||| |:||:     |:||||  
Target 5' taAGCAAAATCCTCTTATTTTCTAta 3'
44 - 69 126.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31512684 3 COSMIC
COSN31554975 56 COSMIC
COSN31559055 56 COSMIC
COSN31575373 66 COSMIC
COSN30179793 94 COSMIC
COSN5296687 138 COSMIC
COSN19454820 203 COSMIC
COSN10077973 389 COSMIC
COSN17029677 445 COSMIC
COSN21988549 446 COSMIC
COSN29460963 447 COSMIC
COSN20108741 480 COSMIC
COSN20697081 512 COSMIC
COSN31569365 564 COSMIC
COSN9030061 754 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770233875 1 dbSNP
rs773852200 2 dbSNP
rs759317614 3 dbSNP
rs767133161 5 dbSNP
rs1421125508 8 dbSNP
rs1410076556 9 dbSNP
rs775075932 14 dbSNP
rs760276509 18 dbSNP
rs1028424497 20 dbSNP
rs763888952 21 dbSNP
rs1377487505 25 dbSNP
rs753848438 26 dbSNP
rs756974432 28 dbSNP
rs765130815 30 dbSNP
rs1366605662 31 dbSNP
rs750604198 34 dbSNP
rs1420238348 36 dbSNP
rs1215281349 37 dbSNP
rs1272602284 38 dbSNP
rs1333409752 39 dbSNP
rs1216089790 43 dbSNP
rs1169596764 46 dbSNP
rs933103821 60 dbSNP
rs533908029 63 dbSNP
rs553865881 64 dbSNP
rs1188366775 65 dbSNP
rs1486482995 66 dbSNP
rs1254959590 67 dbSNP
rs753817659 68 dbSNP
rs1437917982 71 dbSNP
rs966395480 73 dbSNP
rs566576035 77 dbSNP
rs1247302805 87 dbSNP
rs533958377 88 dbSNP
rs1004573924 95 dbSNP
rs971902797 99 dbSNP
rs1234275128 101 dbSNP
rs1357679892 105 dbSNP
rs1475220074 110 dbSNP
rs1447510218 120 dbSNP
rs549113596 127 dbSNP
rs1016329140 130 dbSNP
rs567340856 133 dbSNP
rs919114063 135 dbSNP
rs1399444317 136 dbSNP
rs898948319 139 dbSNP
rs1165468159 140 dbSNP
rs1421881317 147 dbSNP
rs181406783 149 dbSNP
rs185772962 154 dbSNP
rs369172638 159 dbSNP
rs539790110 160 dbSNP
rs1462888995 169 dbSNP
rs558409687 171 dbSNP
rs970884283 178 dbSNP
rs1436643108 185 dbSNP
rs1326015327 190 dbSNP
rs1214796533 195 dbSNP
rs752511187 196 dbSNP
rs1428000642 199 dbSNP
rs1031238521 200 dbSNP
rs1045844101 206 dbSNP
rs1281406378 210 dbSNP
rs1440109419 217 dbSNP
rs1376168326 218 dbSNP
rs1271617835 222 dbSNP
rs1326514506 227 dbSNP
rs1462908710 233 dbSNP
rs907450504 236 dbSNP
rs1400983252 240 dbSNP
rs1409699317 240 dbSNP
rs1362208507 241 dbSNP
rs1438551219 242 dbSNP
rs934933316 248 dbSNP
rs1194837954 250 dbSNP
rs1053280060 258 dbSNP
rs1292986808 264 dbSNP
rs1333349005 268 dbSNP
rs956941118 271 dbSNP
rs893266290 286 dbSNP
rs1011771094 289 dbSNP
rs1028373698 290 dbSNP
rs989532847 295 dbSNP
rs1446543952 299 dbSNP
rs1213706717 309 dbSNP
rs1443070200 311 dbSNP
rs889883684 319 dbSNP
rs1292790207 320 dbSNP
rs1244117365 328 dbSNP
rs1351462379 333 dbSNP
rs758193597 340 dbSNP
rs1156517339 351 dbSNP
rs915227872 367 dbSNP
rs1478270440 371 dbSNP
rs1186963852 372 dbSNP
rs140906743 380 dbSNP
rs540396530 388 dbSNP
rs1423684220 390 dbSNP
rs1191057464 402 dbSNP
rs386757485 410 dbSNP
rs150167238 411 dbSNP
rs138885489 412 dbSNP
rs1051576869 418 dbSNP
rs1213960798 420 dbSNP
rs542275 432 dbSNP
rs1319711278 441 dbSNP
rs746400484 445 dbSNP
rs951840382 450 dbSNP
rs142705857 451 dbSNP
rs191010525 455 dbSNP
rs1413721035 456 dbSNP
rs1312673464 457 dbSNP
rs1286869000 459 dbSNP
rs915652318 462 dbSNP
rs182725214 463 dbSNP
rs149186676 474 dbSNP
rs377335486 474 dbSNP
rs1432334599 477 dbSNP
rs373701340 477 dbSNP
rs201966266 480 dbSNP
rs551939573 496 dbSNP
rs1011886600 499 dbSNP
rs770259514 500 dbSNP
rs72645436 508 dbSNP
rs1191932348 510 dbSNP
rs775870019 529 dbSNP
rs1031122942 530 dbSNP
rs147344957 539 dbSNP
rs1488748107 543 dbSNP
rs111957205 546 dbSNP
rs956993392 550 dbSNP
rs1011579525 553 dbSNP
rs1293246534 556 dbSNP
rs1217779844 557 dbSNP
rs1049956295 566 dbSNP
rs1294763640 567 dbSNP
rs1022508977 571 dbSNP
rs964403056 572 dbSNP
rs868643367 582 dbSNP
rs1298224270 595 dbSNP
rs889855894 596 dbSNP
rs1486557127 597 dbSNP
rs1008756437 602 dbSNP
rs138041078 607 dbSNP
rs1169074808 616 dbSNP
rs1465443227 622 dbSNP
rs1418963775 626 dbSNP
rs1232298621 628 dbSNP
rs1422249280 631 dbSNP
rs149481622 632 dbSNP
rs1159804589 640 dbSNP
rs761276481 641 dbSNP
rs1481613415 642 dbSNP
rs1256082309 643 dbSNP
rs955428442 654 dbSNP
rs1433745959 657 dbSNP
rs1274772966 658 dbSNP
rs1171405549 659 dbSNP
rs376143130 665 dbSNP
rs1339490460 671 dbSNP
rs537978105 673 dbSNP
rs549842683 678 dbSNP
rs1392624471 679 dbSNP
rs1329932287 683 dbSNP
rs1376876662 695 dbSNP
rs73555172 701 dbSNP
rs1456636047 703 dbSNP
rs1026614265 705 dbSNP
rs1335275528 711 dbSNP
rs1335695287 715 dbSNP
rs371641767 716 dbSNP
rs1160018780 718 dbSNP
rs1420973283 722 dbSNP
rs1440575098 723 dbSNP
rs1281372019 724 dbSNP
rs144362375 736 dbSNP
rs1468835865 738 dbSNP
rs1254716709 740 dbSNP
rs1207834044 745 dbSNP
rs1260955694 746 dbSNP
rs1354455859 754 dbSNP
rs951995192 757 dbSNP
rs984587807 758 dbSNP
rs907706450 762 dbSNP
rs940495683 767 dbSNP
rs1446754287 771 dbSNP
rs373940944 772 dbSNP
rs761873022 775 dbSNP
rs368640023 776 dbSNP
rs969769624 779 dbSNP
rs981572175 788 dbSNP
rs1378589378 793 dbSNP
rs767666986 803 dbSNP
rs1454704633 804 dbSNP
rs1436027892 807 dbSNP
rs928423081 811 dbSNP
rs1044724026 815 dbSNP
rs955858533 816 dbSNP
rs1450837957 820 dbSNP
rs376879745 830 dbSNP
rs1238679115 833 dbSNP
rs1003246422 839 dbSNP
rs1453323811 840 dbSNP
rs1191193924 846 dbSNP
rs914819505 847 dbSNP
rs1234379886 852 dbSNP
rs186388945 858 dbSNP
rs773144328 860 dbSNP
rs572086489 875 dbSNP
rs1011044274 876 dbSNP
rs1402134884 877 dbSNP
rs1022986642 881 dbSNP
rs911364489 884 dbSNP
rs944237267 891 dbSNP
rs765262092 892 dbSNP
rs1334001512 898 dbSNP
rs1373476416 914 dbSNP
rs1378277461 914 dbSNP
rs1185803120 916 dbSNP
rs897243443 922 dbSNP
rs752599333 923 dbSNP
rs555500003 930 dbSNP
rs994566789 945 dbSNP
rs1029659773 952 dbSNP
rs1048418961 960 dbSNP
rs1486378957 960 dbSNP
rs568038 979 dbSNP
rs1199286517 983 dbSNP
rs1006124261 984 dbSNP
rs982867379 987 dbSNP
rs1015658310 988 dbSNP
rs560966833 989 dbSNP
rs1220849049 997 dbSNP
rs970273808 999 dbSNP
rs1277823398 1000 dbSNP
rs1415576721 1004 dbSNP
rs1342380470 1006 dbSNP
rs1332245700 1018 dbSNP
rs529790681 1023 dbSNP
rs1413891730 1024 dbSNP
rs1002712302 1031 dbSNP
rs1172648384 1035 dbSNP
rs973243675 1036 dbSNP
rs1463878404 1040 dbSNP
rs920538734 1041 dbSNP
rs1188256583 1044 dbSNP
rs1197307929 1050 dbSNP
rs1235296391 1051 dbSNP
rs1186209910 1053 dbSNP
rs75568536 1061 dbSNP
rs1274331090 1069 dbSNP
rs980446250 1072 dbSNP
rs756815068 1073 dbSNP
rs1234180725 1083 dbSNP
rs1254275541 1085 dbSNP
rs927637861 1093 dbSNP
rs556603336 1094 dbSNP
rs968385647 1095 dbSNP
rs577971700 1098 dbSNP
rs938988492 1100 dbSNP
rs944167282 1110 dbSNP
rs1052145777 1126 dbSNP
rs77023778 1135 dbSNP
rs560190087 1137 dbSNP
rs1406796050 1142 dbSNP
rs111561113 1144 dbSNP
rs542931374 1146 dbSNP
rs1401666640 1150 dbSNP
rs1162213321 1152 dbSNP
rs1470212895 1178 dbSNP
rs1461325272 1183 dbSNP
rs1323996504 1185 dbSNP
rs900117233 1186 dbSNP
rs1234069818 1188 dbSNP
rs1392915319 1190 dbSNP
rs1387390528 1194 dbSNP
rs997105015 1202 dbSNP
rs1323808133 1207 dbSNP
rs1295182649 1208 dbSNP
rs561111714 1224 dbSNP
rs1048370202 1228 dbSNP
rs1029880101 1245 dbSNP
rs142382974 1249 dbSNP
rs1334092099 1250 dbSNP
rs549647175 1258 dbSNP
rs146398816 1267 dbSNP
rs1347846042 1268 dbSNP
rs1322505155 1270 dbSNP
rs1004193115 1278 dbSNP
rs1381674900 1279 dbSNP
rs1156286678 1282 dbSNP
rs1274539947 1285 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 143903.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "HITS-CLIP data was present in GSM714643. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucUCGUUCUGGGGCAGAGAUuu 5'
            | |:||||||||||||||  
Target 5' auAACGAGACCCCGUCUCUA-- 3'
10 - 29
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 143903.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000525126.1 | 3UTR | UGGGCAACAUAACGAGACCCCGUCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714643
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000525126.1 | 3UTR | CUGGGCAACAUAACGAGACCCCGUCUCUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000525126.1 | 3UTR | CAACAUAACGAGACCCCGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis -0.404 3.5e-2 -0.690 2.7e-4 21 Click to see details
GSE28260 Renal cortex and medulla 0.508 3.8e-2 0.511 3.7e-2 13 Click to see details
GSE28544 Breast cancer 0.295 8.1e-2 0.276 9.6e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.204 1.8e-1 -0.190 1.9e-1 23 Click to see details
GSE32688 Pancreatic cancer -0.157 2.0e-1 -0.176 1.7e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.175 2.1e-1 0.235 1.3e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.131 2.7e-1 0.016 4.7e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
186 hsa-miR-1303 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035871 SOAT1 sterol O-acyltransferase 1 1 1
MIRT035872 FHOD3 formin homology 2 domain containing 3 1 1
MIRT035873 RPL7A ribosomal protein L7a 1 1
MIRT035874 NCAPD2 non-SMC condensin I complex subunit D2 1 1
MIRT035875 RPS8 ribosomal protein S8 1 1
MIRT035876 AHNAK AHNAK nucleoprotein 1 1
MIRT035877 ACTB actin beta 1 1
MIRT035878 DEF8 differentially expressed in FDCP 8 homolog 1 1
MIRT035879 MET MET proto-oncogene, receptor tyrosine kinase 1 1
MIRT035880 MED13 mediator complex subunit 13 1 1
MIRT035881 FAT3 FAT atypical cadherin 3 1 1
MIRT035882 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT035883 RPS16 ribosomal protein S16 1 1
MIRT035884 CDK6 cyclin dependent kinase 6 1 1
MIRT035885 GEMIN5 gem nuclear organelle associated protein 5 1 1
MIRT035886 PITRM1 pitrilysin metallopeptidase 1 1 1
MIRT035887 PRRC2A proline rich coiled-coil 2A 1 1
MIRT035888 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 1 1
MIRT035889 MLLT6 MLLT6, PHD finger containing 1 1
MIRT035890 EIF3I eukaryotic translation initiation factor 3 subunit I 1 1
MIRT035891 FASN fatty acid synthase 1 1
MIRT035892 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT035893 HSCB HscB mitochondrial iron-sulfur cluster cochaperone 1 1
MIRT035894 PSME4 proteasome activator subunit 4 1 1
MIRT035895 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT035896 ZNF264 zinc finger protein 264 1 1
MIRT035897 HYLS1 HYLS1, centriolar and ciliogenesis associated 1 1
MIRT035898 USP54 ubiquitin specific peptidase 54 1 1
MIRT035899 L1TD1 LINE1 type transposase domain containing 1 1 1
MIRT035900 OR51E2 olfactory receptor family 51 subfamily E member 2 1 1
MIRT053762 CLDN18 claudin 18 3 1
MIRT060730 RPS3 ribosomal protein S3 2 2
MIRT083986 RAB22A RAB22A, member RAS oncogene family 2 2
MIRT098550 TBPL1 TATA-box binding protein like 1 2 6
MIRT134983 TWF1 twinfilin actin binding protein 1 2 4
MIRT136956 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT222065 PURB purine rich element binding protein B 2 2
MIRT239574 UBN2 ubinuclein 2 2 4
MIRT261820 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT264698 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT308476 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT377481 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT442304 NEU3 neuraminidase 3 2 2
MIRT446083 SLC30A10 solute carrier family 30 member 10 2 2
MIRT449606 PRPF4 pre-mRNA processing factor 4 2 2
MIRT453767 NUCB1 nucleobindin 1 2 10
MIRT455603 SRSF3 serine and arginine rich splicing factor 3 2 2
MIRT455913 KIF2C kinesin family member 2C 2 2
MIRT460091 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT460866 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461339 NUP133 nucleoporin 133 2 2
MIRT463769 YOD1 YOD1 deubiquitinase 2 2
MIRT466368 THAP1 THAP domain containing 1 2 4
MIRT467168 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468703 SDHD succinate dehydrogenase complex subunit D 2 2
MIRT469122 RNF126 ring finger protein 126 2 2
MIRT472426 NCBP2 nuclear cap binding protein subunit 2 2 4
MIRT479420 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT484260 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT485468 IL6ST interleukin 6 signal transducer 2 10
MIRT490237 H2AFZ H2A histone family member Z 2 6
MIRT491002 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT492127 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT499169 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT499825 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT501794 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT503441 GINS4 GINS complex subunit 4 2 4
MIRT503688 MAVS mitochondrial antiviral signaling protein 2 5
MIRT506926 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT511430 HOXA10 homeobox A10 2 6
MIRT512415 LAYN layilin 2 4
MIRT513791 NIPAL3 NIPA like domain containing 3 2 4
MIRT516163 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 4
MIRT516513 PARK2 parkin RBR E3 ubiquitin protein ligase 2 2
MIRT516915 HINFP histone H4 transcription factor 2 2
MIRT517102 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517350 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT518019 ABHD15 abhydrolase domain containing 15 2 2
MIRT520945 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT525250 RNF213 ring finger protein 213 2 2
MIRT530634 PPIC peptidylprolyl isomerase C 2 4
MIRT530671 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531563 ILDR1 immunoglobulin like domain containing receptor 1 2 2
MIRT538205 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT538419 COLEC10 collectin subfamily member 10 2 2
MIRT541964 ZNF485 zinc finger protein 485 2 2
MIRT543088 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT543257 ZNF662 zinc finger protein 662 2 2
MIRT543589 KIAA1549 KIAA1549 2 2
MIRT543955 RNF20 ring finger protein 20 2 2
MIRT544043 C9orf64 chromosome 9 open reading frame 64 2 4
MIRT548064 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548240 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT548442 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548623 DAZAP1 DAZ associated protein 1 2 4
MIRT548770 COLEC12 collectin subfamily member 12 2 2
MIRT549506 HDDC2 HD domain containing 2 2 4
MIRT551924 AKAP8 A-kinase anchoring protein 8 2 4
MIRT555656 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT556286 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT557012 HOXD13 homeobox D13 2 4
MIRT563907 CLSPN claspin 2 2
MIRT565527 SON SON DNA binding protein 2 2
MIRT568000 COMMD2 COMM domain containing 2 2 2
MIRT569831 PLA2G16 phospholipase A2 group XVI 2 4
MIRT573905 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT616589 KLHL9 kelch like family member 9 2 2
MIRT617137 ZNF556 zinc finger protein 556 2 2
MIRT617400 API5 apoptosis inhibitor 5 2 2
MIRT617455 CCS copper chaperone for superoxide dismutase 2 2
MIRT617799 ZNF793 zinc finger protein 793 2 2
MIRT618190 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT618303 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT618329 ZNF813 zinc finger protein 813 2 2
MIRT618820 PHF20 PHD finger protein 20 2 2
MIRT619153 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619530 ZNF708 zinc finger protein 708 2 2
MIRT619849 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT620806 SLC26A2 solute carrier family 26 member 2 2 2
MIRT621312 YIPF4 Yip1 domain family member 4 2 2
MIRT621358 GUCA1B guanylate cyclase activator 1B 2 2
MIRT621366 ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2 2
MIRT621547 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT621883 TAOK1 TAO kinase 1 2 2
MIRT622451 RNF19B ring finger protein 19B 2 2
MIRT623404 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT623587 IPO9 importin 9 2 2
MIRT623974 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT624086 DPP8 dipeptidyl peptidase 8 2 2
MIRT624108 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT632486 RNF8 ring finger protein 8 2 2
MIRT634057 PLIN3 perilipin 3 2 2
MIRT634657 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT640682 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT641242 CENPN centromere protein N 2 2
MIRT642260 ZNF677 zinc finger protein 677 2 2
MIRT642954 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT644326 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT644632 ICA1L islet cell autoantigen 1 like 2 2
MIRT645721 POLR3A RNA polymerase III subunit A 2 2
MIRT647850 LYPLA1 lysophospholipase I 2 2
MIRT649281 NEK8 NIMA related kinase 8 2 2
MIRT650038 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT650354 RRP36 ribosomal RNA processing 36 2 2
MIRT651144 ZNF384 zinc finger protein 384 2 2
MIRT651778 UTP6 UTP6, small subunit processome component 2 2
MIRT652576 TLCD2 TLC domain containing 2 2 2
MIRT654621 PTPRJ protein tyrosine phosphatase, receptor type J 2 2
MIRT656023 MYO5A myosin VA 2 2
MIRT656105 MSRB3 methionine sulfoxide reductase B3 2 2
MIRT657749 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT657924 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT658848 DUSP19 dual specificity phosphatase 19 2 2
MIRT659100 DENND6A DENN domain containing 6A 2 2
MIRT659153 DCX doublecortin 2 2
MIRT660870 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT661941 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT663577 C10orf32 BLOC-1 related complex subunit 7 2 2
MIRT664625 WDPCP WD repeat containing planar cell polarity effector 2 4
MIRT666562 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT669992 GPR156 G protein-coupled receptor 156 2 4
MIRT670445 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670853 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671942 SPPL3 signal peptide peptidase like 3 2 2
MIRT674269 LMOD3 leiomodin 3 2 2
MIRT674424 MIOX myo-inositol oxygenase 2 4
MIRT674982 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT675038 BACE2 beta-site APP-cleaving enzyme 2 2 4
MIRT675309 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT675641 TTPAL alpha tocopherol transfer protein like 2 2
MIRT688688 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT689369 ZNF101 zinc finger protein 101 2 2
MIRT689605 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691715 LARS leucyl-tRNA synthetase 2 2
MIRT695473 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695530 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT695878 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT696586 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT703007 HEATR5A HEAT repeat containing 5A 2 2
MIRT707942 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 2
MIRT709765 GPR183 G protein-coupled receptor 183 2 2
MIRT710332 ZNF669 zinc finger protein 669 2 2
MIRT713249 ZFP30 ZFP30 zinc finger protein 2 2
MIRT716613 RBM18 RNA binding motif protein 18 2 2
MIRT733414 BAG2 BCL2 associated athanogene 2 2 0
MIRT756135 THSD7A thrombospondin type 1 domain containing 7A 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1303 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-1303 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1303 Rituximab sensitive High Diffuse Large B-Cell Lymphoma cell line (DB, NU-DHL-1, NU-DUL-1, MC-116, SU-DHL-4, SU-DHL-5, FARAGE, HBL-1, OCI-Ly3, OCI-Ly7, OCI-Ly8, OCI-Ly19, RIVA, SU-DHL-8, U2932)
hsa-miR-1303 Etoposide 36462 NSC141540 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vinorelbine 44424639 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Vincristine 5978 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant High Colorectal Cancer cell line (HCT8)
hsa-mir-1303 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-1303 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-1303 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1303 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1303 Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1303 Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-1303 Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1303 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1303 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1303 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-1303 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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