miRTarBase - #MIRT512550


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pre-miRNA Information
pre-miRNA hsa-mir-4653   
Genomic Coordinates chr7: 101159473 - 101159555
Description Homo sapiens miR-4653 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4653-5p
Sequence 10| UCUCUGAGCAAGGCUUAACACC |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs566953516 2 dbSNP
rs1307365749 4 dbSNP
rs1226652366 6 dbSNP
rs1216592229 12 dbSNP
rs1283699546 15 dbSNP
rs934609749 20 dbSNP
rs1377199291 21 dbSNP
rs1282994534 22 dbSNP
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B8DF7B miR-4653 Predictive Biomarker (PRD) Transcriptomic Data . . . .
Gene Information
Gene Symbol MFN2   
Synonyms CMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, HMSN6A, HSG, MARF
Description mitofusin 2
Transcript NM_001127660   
Other Transcripts NM_014874   
Expression
Putative miRNA Targets on MFN2
3'UTR of MFN2
(miRNA target sites are highlighted)		 
>MFN2|NM_001127660|3'UTR
   1 TGGGCACCTGAGGCGGAGTCTGCGTGGAGAGGGGCGGTGCTGCCAGCCCTAAGTGCCATGTGGGCTCCCCCAGGGGCACG
  81 TGTGGCTCCTGCCCCCTGGCCACTGCCAAGAGAATGAAGCACCCAGTCTCGTACCATTTTGAGCCCTCCAGCACTACTTA
 161 TTTTCCCCCACCTTTGCCTGCTGTTGCTGGAAGAGCTGGCTCATACCCCCAAAGGACACTTTCAGCGACAGCTATGGACA
 241 GCATGGTACCAAGGAGTTAAGTTGAGGCTTTTTCCAGCTTTCTCTGGTTCATTTGATTGCTTGATAAGGCCTCAGGATCT
 321 CAGCATTGCACAATGCCTCATGGAAGCCTTTGAGGGTATCACACAGACACCCCCACCTTCCTCCAGCCTGTGCGCACCTG
 401 CCCTCCTTGCAGCCCAGCACACCTGCAGGTGTAAGGGACGATTGGAGTTTCTTCCCAGAGAGTCTGTCCCAGAAGGACTG
 481 TGGCTTGTGTGTGTCCATCTCGCCTGTTGGCTCAGTGCTTCATCCCATTTGCAGAGCCTCAGACACGTCTTGGTGGTGAG
 561 GCTCAGTTACCCCTGGGCTTAGGCTGAGGCGGGCCCTGTGCTGGGGGTGGTAGAAAGGATGCTGCTGAGGCAGCTGGAGG
 641 AGTGGGAGTAGCTCAGAGGGGAGGGCTGTTGGATGTATGGGGAGCTGGCAGAGCAGGTGGCAGTCACTGGGACAAGGAGG
 721 GACTTGCCTCTCTTCTCATTATTGTGTCCTTTGCTTTAGTGTCAGTCCTGGACTTGTGCAGGCCTGTTTTGTGTAGATCT
 801 GTTTTGGAAGATGGCATGGTCTAGGTGGTTGAAGGATGTAGTAGAAGGATGGATGGTGGAAGGTGGGGACGTTGGTGGCT
 881 GGCTGAGGTGCATGGGCCCCACACAGGACAGCTGGAGAATGGGCCGTCCACTTGGCCTCGTTCTGCGAGGGGCTCATGGG
 961 TCTGAGAGCCCCCACCCACTAGGCTTGATTGCATCCCTGTTGTGCCCTTTAAGAGACATGTTTCCACCCCACCCCCAACC
1041 TTGTCCCAAGTGCCCTGGACTAAATTTCCTGTGCCAGTGACTGCAGTTGGCCAAGGGACAATGTGGAAAACCCAGTGTCC
1121 ATCTTTCCACCCTCCCTGATCTCCAGAACCTTCGACTGACCCCCTTGTCTTTATGCTGATGTTGAGTTTTGGGATTGTTA
1201 CTGGTTGAAGTGGGGGCAGATGCCTGTCACCAAGGTGTTGACTGTGTGAGAAAAGCAGTTTGGGTGACAAATCCTGTGTG
1281 GCACAAGTTGGATCGCTTCCTAGAAATAAGCAACACCTCTCCCAAAAAGCAGCCCACAAGGCAGGGGCCCAGCAGCCCAG
1361 CCATCACTCATCTTTGAGGAAATGAGTTGGTAGCCTCTGTGCACTGTTTGGTGGCCACATCACAGGTGATGTCCTGTTCA
1441 CATACCTGCTTGTATTTAAAGCCCTCAGTCTGTCCTGTTGTGTGGGGCGAAGTGATGGACTCTGCCAGGTGGACATGCTG
1521 TGGGTGGATGTTCCCGGCGTGTGCCGGGCCTGAATGGACAGGGGCCACTTCACAGCATGTCAGGGAAAATCACTGTCACA
1601 CAATTCCAATGGATTTTGTGCTCTTTTTGAAAAAAAAAAATTCTTTAGCGTAAACATGAATTTTTTTTCAATGTAGCCCC
1681 TGGGGAATGAATGAAATTTTGAGCTTCTTCAATACGTAAAATTAAATTTATACCACTGAGGGAGAGACCCTTTCTGAAAG
1761 AAGTATGGCCAAAAGCACTTTAATGCTGCTGACATTGTTGTTTTTATGTTCATTTGCTGGAGCGCAAGACGTGCTGACAC
1841 AGTGAGTTTTCTCTGATGTATTTAAGGTGATGTATTTGCTTGAGTTACTCCTGTATCATTGCTCATAATATTGGAAACTA
1921 AAATAAAACCTAGTTGGAAATCCTTTGTGAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccacaAUUCGGAACGAGUCUCu 5'
               |::|  | |||||||| 
Target 5' aggagTGGGAGTAGCTCAGAGg 3'
 638 - 659 153.00 -18.80
2 
miRNA  3' ccAC-AAUUCGG---AAC------GAGUCUcu 5'
            || || | ||   |||      ||||||  
Target 5' agTGCTTCATCCCATTTGCAGAGCCTCAGAca 3'
 514 - 545 126.00 -9.50
3 
miRNA  3' ccacAAUUCGGA-ACGAGUCUCu 5'
              | :||::| | | ||||| 
Target 5' cgatTGGAGTTTCTTCCCAGAGa 3'
 439 - 461 122.00 -12.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
378136 16 ClinVar
874805 27 ClinVar
292379 37 ClinVar
292380 58 ClinVar
292381 59 ClinVar
292382 122 ClinVar
875744 132 ClinVar
292383 220 ClinVar
875745 227 ClinVar
292384 232 ClinVar
292385 257 ClinVar
292386 298 ClinVar
876736 305 ClinVar
873908 382 ClinVar
292387 414 ClinVar
292388 609 ClinVar
292389 731 ClinVar
292390 778 ClinVar
874854 814 ClinVar
292391 865 ClinVar
292392 871 ClinVar
292393 897 ClinVar
292394 913 ClinVar
292395 936 ClinVar
292396 947 ClinVar
875789 1035 ClinVar
876785 1055 ClinVar
292397 1069 ClinVar
292398 1101 ClinVar
292399 1154 ClinVar
292400 1162 ClinVar
873970 1223 ClinVar
292401 1259 ClinVar
292402 1277 ClinVar
292403 1296 ClinVar
292404 1393 ClinVar
292405 1489 ClinVar
874907 1536 ClinVar
292406 1540 ClinVar
292407 1547 ClinVar
292408 1563 ClinVar
292409 1577 ClinVar
292410 1630 ClinVar
292411 1630 ClinVar
876834 1663 ClinVar
292412 1707 ClinVar
876835 1764 ClinVar
292413 1794 ClinVar
292414 1795 ClinVar
876836 1831 ClinVar
874027 1903 ClinVar
COSN31594856 24 COSMIC
COSN31506258 25 COSMIC
COSN30506806 36 COSMIC
COSN19670380 59 COSMIC
COSN13461165 81 COSMIC
COSN31557092 90 COSMIC
COSN30452070 95 COSMIC
COSN31490381 111 COSMIC
COSN1088054 250 COSMIC
COSN31611872 269 COSMIC
COSN17037847 548 COSMIC
COSN16288581 731 COSMIC
COSN24453665 822 COSMIC
COSN31959456 1644 COSMIC
COSN28732712 1680 COSMIC
COSN7174485 1686 COSMIC
COSN30126559 1723 COSMIC
COSM8825578 1755 COSMIC
COSM162464 1819 COSMIC
COSN31519963 1903 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779118705 1 dbSNP
rs748456191 2 dbSNP
rs1472261427 6 dbSNP
rs1156820690 7 dbSNP
rs772177020 8 dbSNP
rs11588340 9 dbSNP
rs1454124952 10 dbSNP
rs773112358 12 dbSNP
rs865831647 13 dbSNP
rs369188276 15 dbSNP
rs141339523 16 dbSNP
rs776646123 17 dbSNP
rs759132337 20 dbSNP
rs764900107 21 dbSNP
rs752251662 22 dbSNP
rs762707869 24 dbSNP
rs763630899 25 dbSNP
rs374800481 27 dbSNP
rs747628464 30 dbSNP
rs1356873679 34 dbSNP
rs376785987 35 dbSNP
rs369206304 36 dbSNP
rs377468070 37 dbSNP
rs1191422943 39 dbSNP
rs766811616 40 dbSNP
rs1488929916 42 dbSNP
rs1252617669 47 dbSNP
rs779026842 52 dbSNP
rs886045221 58 dbSNP
rs1042842 59 dbSNP
rs1471503970 67 dbSNP
rs1161149388 70 dbSNP
rs944651399 70 dbSNP
rs1164767218 72 dbSNP
rs1392406042 73 dbSNP
rs111806773 81 dbSNP
rs539071985 83 dbSNP
rs1372847364 89 dbSNP
rs1348221336 93 dbSNP
rs1438816885 97 dbSNP
rs1294375580 100 dbSNP
rs1350146080 102 dbSNP
rs976349864 111 dbSNP
rs919333072 114 dbSNP
rs929410460 117 dbSNP
rs886045222 122 dbSNP
rs1048870606 123 dbSNP
rs1228261177 124 dbSNP
rs552975414 131 dbSNP
rs1323018606 137 dbSNP
rs572972408 147 dbSNP
rs1286223867 148 dbSNP
rs1336592034 150 dbSNP
rs951336065 155 dbSNP
rs984442568 169 dbSNP
rs1252354585 171 dbSNP
rs909740743 174 dbSNP
rs1233844736 181 dbSNP
rs1161416078 188 dbSNP
rs1272428603 194 dbSNP
rs947868603 200 dbSNP
rs113306881 210 dbSNP
rs558848411 220 dbSNP
rs886045223 220 dbSNP
rs1370174316 223 dbSNP
rs184254413 227 dbSNP
rs939334852 228 dbSNP
rs41278636 232 dbSNP
rs575528575 233 dbSNP
rs1447876670 235 dbSNP
rs907129403 238 dbSNP
rs1282972138 244 dbSNP
rs188139414 251 dbSNP
rs557772799 257 dbSNP
rs1044347963 262 dbSNP
rs1339629421 268 dbSNP
rs577926236 274 dbSNP
rs1206858954 287 dbSNP
rs200079179 289 dbSNP
rs1275026671 294 dbSNP
rs886045224 298 dbSNP
rs1441665907 299 dbSNP
rs56150064 301 dbSNP
rs80118679 305 dbSNP
rs1239110566 319 dbSNP
rs1011765647 330 dbSNP
rs1018027685 333 dbSNP
rs1389640996 336 dbSNP
rs752371623 338 dbSNP
rs1428003798 344 dbSNP
rs1021393499 348 dbSNP
rs1170735719 355 dbSNP
rs968592519 356 dbSNP
rs1411780263 357 dbSNP
rs1361391085 363 dbSNP
rs1449488578 372 dbSNP
rs986305299 375 dbSNP
rs1230108993 376 dbSNP
rs1017868209 378 dbSNP
rs966318629 382 dbSNP
rs746355588 384 dbSNP
rs976068982 384 dbSNP
rs919283174 394 dbSNP
rs560577796 395 dbSNP
rs985253798 396 dbSNP
rs764567898 397 dbSNP
rs772468764 399 dbSNP
rs529323817 404 dbSNP
rs1208049441 406 dbSNP
rs558887681 414 dbSNP
rs1447762514 416 dbSNP
rs1190637991 420 dbSNP
rs984085294 423 dbSNP
rs1477855055 427 dbSNP
rs1292650041 432 dbSNP
rs1427702680 434 dbSNP
rs1376864535 436 dbSNP
rs1044247272 440 dbSNP
rs1436619643 441 dbSNP
rs907118066 443 dbSNP
rs1171418887 446 dbSNP
rs1330147056 447 dbSNP
rs1215878848 452 dbSNP
rs1276338902 453 dbSNP
rs909762785 453 dbSNP
rs1273100262 458 dbSNP
rs938627290 459 dbSNP
rs969266713 460 dbSNP
rs980973798 463 dbSNP
rs1202620501 470 dbSNP
rs1042275958 488 dbSNP
rs1466236004 490 dbSNP
rs1210654603 493 dbSNP
rs928041609 502 dbSNP
rs1052701641 508 dbSNP
rs1486228792 523 dbSNP
rs1197043358 528 dbSNP
rs748737897 533 dbSNP
rs1011253676 537 dbSNP
rs913925666 543 dbSNP
rs1043164746 547 dbSNP
rs1410384163 548 dbSNP
rs1459348423 557 dbSNP
rs1043994612 565 dbSNP
rs562708886 574 dbSNP
rs1007735902 575 dbSNP
rs757275978 575 dbSNP
rs1384670469 580 dbSNP
rs977112070 583 dbSNP
rs889584294 591 dbSNP
rs531807907 592 dbSNP
rs1187548566 593 dbSNP
rs1007725099 594 dbSNP
rs1418913987 597 dbSNP
rs1426769425 599 dbSNP
rs1286287076 604 dbSNP
rs747291228 609 dbSNP
rs886045225 609 dbSNP
rs924976061 609 dbSNP
rs1176260337 610 dbSNP
rs1017815697 621 dbSNP
rs966266157 641 dbSNP
rs1175801453 646 dbSNP
rs1376267656 648 dbSNP
rs1208177462 660 dbSNP
rs1435166070 665 dbSNP
rs1312039593 669 dbSNP
rs1357142662 677 dbSNP
rs886789118 678 dbSNP
rs1005608224 700 dbSNP
rs1181907104 708 dbSNP
rs1250075163 714 dbSNP
rs552002311 717 dbSNP
rs969675259 727 dbSNP
rs1367341765 728 dbSNP
rs774166848 728 dbSNP
rs112550280 731 dbSNP
rs1360704784 733 dbSNP
rs1164541762 738 dbSNP
rs71647025 746 dbSNP
rs1225507454 747 dbSNP
rs950746112 750 dbSNP
rs112854268 778 dbSNP
rs1348143610 781 dbSNP
rs1352111021 782 dbSNP
rs988251409 790 dbSNP
rs1210703540 792 dbSNP
rs909283625 798 dbSNP
rs1276953275 800 dbSNP
rs1338680394 800 dbSNP
rs1449043878 801 dbSNP
rs546256596 802 dbSNP
rs979891882 806 dbSNP
rs1242012896 808 dbSNP
rs1447786529 809 dbSNP
rs1195565701 810 dbSNP
rs1395988256 811 dbSNP
rs946755545 812 dbSNP
rs1453994144 813 dbSNP
rs771869272 814 dbSNP
rs910548046 815 dbSNP
rs1272866352 818 dbSNP
rs1402193836 818 dbSNP
rs943659654 820 dbSNP
rs1256046144 822 dbSNP
rs1189017776 824 dbSNP
rs1318943434 824 dbSNP
rs1385320782 824 dbSNP
rs1344515668 825 dbSNP
rs1432336813 826 dbSNP
rs1327328241 828 dbSNP
rs1448444243 831 dbSNP
rs776771447 835 dbSNP
rs1371007294 839 dbSNP
rs1233128476 858 dbSNP
rs886045226 865 dbSNP
rs1052938034 867 dbSNP
rs886045227 871 dbSNP
rs902049376 872 dbSNP
rs929448885 873 dbSNP
rs1317175053 874 dbSNP
rs1383644153 878 dbSNP
rs566508518 883 dbSNP
rs1227892557 893 dbSNP
rs1046817881 894 dbSNP
rs1455115346 897 dbSNP
rs3088064 897 dbSNP
rs1205651189 899 dbSNP
rs1255844622 901 dbSNP
rs14305 913 dbSNP
rs1202721540 919 dbSNP
rs1243167397 924 dbSNP
rs1017045915 926 dbSNP
rs556049501 927 dbSNP
rs886045228 936 dbSNP
rs1175005491 937 dbSNP
rs569028508 940 dbSNP
rs1467475629 941 dbSNP
rs765105334 947 dbSNP
rs111706935 948 dbSNP
rs1158920276 952 dbSNP
rs1411242673 956 dbSNP
rs1215388749 963 dbSNP
rs960541367 967 dbSNP
rs1300952286 968 dbSNP
rs987947332 968 dbSNP
rs1225848720 976 dbSNP
rs1264266673 983 dbSNP
rs1329139539 985 dbSNP
rs1206278306 990 dbSNP
rs1021059309 992 dbSNP
rs1040835424 996 dbSNP
rs901984598 1007 dbSNP
rs968573663 1011 dbSNP
rs997693859 1018 dbSNP
rs1434651822 1019 dbSNP
rs1176946772 1020 dbSNP
rs1411135773 1026 dbSNP
rs763004280 1029 dbSNP
rs1347055569 1031 dbSNP
rs56333319 1035 dbSNP
rs951038336 1055 dbSNP
rs1365808230 1060 dbSNP
rs886045229 1069 dbSNP
rs943371235 1072 dbSNP
rs557971062 1081 dbSNP
rs577855896 1092 dbSNP
rs1329000104 1095 dbSNP
rs1337146882 1100 dbSNP
rs41278638 1101 dbSNP
rs1279338276 1102 dbSNP
rs1285686095 1110 dbSNP
rs553732662 1112 dbSNP
rs970095767 1113 dbSNP
rs573712454 1116 dbSNP
rs887942805 1118 dbSNP
rs1274307316 1119 dbSNP
rs941146729 1121 dbSNP
rs980132416 1127 dbSNP
rs1184291593 1132 dbSNP
rs774886957 1145 dbSNP
rs542662190 1149 dbSNP
rs542684406 1154 dbSNP
rs988664521 1155 dbSNP
rs115706485 1162 dbSNP
rs1438608807 1165 dbSNP
rs1304069092 1166 dbSNP
rs947355178 1170 dbSNP
rs1043098164 1191 dbSNP
rs910867042 1195 dbSNP
rs1250819656 1202 dbSNP
rs767945745 1204 dbSNP
rs1056411665 1217 dbSNP
rs531732785 1223 dbSNP
rs545270206 1225 dbSNP
rs896362523 1235 dbSNP
rs1040783681 1237 dbSNP
rs1321621898 1239 dbSNP
rs900928111 1254 dbSNP
rs116156978 1259 dbSNP
rs1410191939 1265 dbSNP
rs1047924745 1268 dbSNP
rs886675490 1276 dbSNP
rs766342161 1277 dbSNP
rs1181286785 1278 dbSNP
rs1349048739 1282 dbSNP
rs965092427 1283 dbSNP
rs1416973655 1285 dbSNP
rs976016439 1287 dbSNP
rs923532171 1292 dbSNP
rs760405586 1295 dbSNP
rs763783578 1296 dbSNP
rs1447954447 1309 dbSNP
rs150255183 1311 dbSNP
rs905842906 1316 dbSNP
rs1355374188 1317 dbSNP
rs1384393483 1317 dbSNP
rs548087859 1319 dbSNP
rs1253156362 1322 dbSNP
rs566450566 1336 dbSNP
rs528902109 1337 dbSNP
rs1195467205 1351 dbSNP
rs1035697573 1367 dbSNP
rs1272706609 1368 dbSNP
rs960152602 1370 dbSNP
rs1481974480 1381 dbSNP
rs886045230 1393 dbSNP
rs1207962484 1399 dbSNP
rs1020140473 1412 dbSNP
rs1802534 1416 dbSNP
rs549060411 1420 dbSNP
rs568961334 1426 dbSNP
rs1462684142 1438 dbSNP
rs1258218285 1444 dbSNP
rs1295889349 1446 dbSNP
rs978672962 1449 dbSNP
rs937662607 1466 dbSNP
rs113173297 1470 dbSNP
rs896153352 1480 dbSNP
rs11554507 1489 dbSNP
rs756822984 1490 dbSNP
rs1408994676 1496 dbSNP
rs1452703214 1497 dbSNP
rs1374314050 1499 dbSNP
rs1319371555 1509 dbSNP
rs903697591 1518 dbSNP
rs1000682209 1527 dbSNP
rs1475431406 1534 dbSNP
rs778755558 1536 dbSNP
rs1344071943 1537 dbSNP
rs964791973 1539 dbSNP
rs557643473 1540 dbSNP
rs1204376755 1543 dbSNP
rs191440012 1546 dbSNP
rs3737960 1547 dbSNP
rs1195633872 1548 dbSNP
rs1243018118 1553 dbSNP
rs1477889143 1558 dbSNP
rs1174787998 1561 dbSNP
rs551566332 1563 dbSNP
rs1157697056 1564 dbSNP
rs1382169683 1565 dbSNP
rs78523898 1577 dbSNP
rs909434911 1581 dbSNP
rs1394815751 1585 dbSNP
rs1298308335 1586 dbSNP
rs1330198649 1588 dbSNP
rs963896394 1592 dbSNP
rs746717767 1602 dbSNP
rs980254279 1604 dbSNP
rs1037921799 1605 dbSNP
rs1227725900 1610 dbSNP
rs906127403 1611 dbSNP
rs373797699 1612 dbSNP
rs1207017388 1619 dbSNP
rs556187021 1620 dbSNP
rs1451310633 1624 dbSNP
rs1197710381 1630 dbSNP
rs1221477731 1630 dbSNP
rs35943162 1630 dbSNP
rs886045231 1630 dbSNP
rs886045232 1630 dbSNP
rs79081416 1631 dbSNP
rs1454873266 1639 dbSNP
rs1035683232 1644 dbSNP
rs917620952 1650 dbSNP
rs138448755 1651 dbSNP
rs1262339548 1652 dbSNP
rs1010299066 1657 dbSNP
rs1350317529 1661 dbSNP
rs1365990745 1661 dbSNP
rs1409099002 1661 dbSNP
rs1020801224 1663 dbSNP
rs183920451 1669 dbSNP
rs1042716466 1673 dbSNP
rs968549221 1674 dbSNP
rs1280798128 1676 dbSNP
rs903729868 1678 dbSNP
rs936510042 1679 dbSNP
rs1220564032 1686 dbSNP
rs1038899854 1688 dbSNP
rs1490606163 1690 dbSNP
rs1186626842 1692 dbSNP
rs1204954614 1695 dbSNP
rs1383152051 1702 dbSNP
rs1249012323 1704 dbSNP
rs1196256602 1705 dbSNP
rs543365043 1707 dbSNP
rs1367392114 1709 dbSNP
rs1165718996 1711 dbSNP
rs1442346806 1714 dbSNP
rs1366358994 1716 dbSNP
rs772365631 1717 dbSNP
rs1428846369 1719 dbSNP
rs963992846 1724 dbSNP
rs1398541916 1729 dbSNP
rs1376221946 1732 dbSNP
rs976400039 1735 dbSNP
rs1043042 1736 dbSNP
rs1314868299 1739 dbSNP
rs886453383 1745 dbSNP
rs777822288 1747 dbSNP
rs565302510 1749 dbSNP
rs922284312 1750 dbSNP
rs1201886061 1751 dbSNP
rs1043058 1755 dbSNP
rs963628810 1761 dbSNP
rs1252524417 1762 dbSNP
rs1480958058 1770 dbSNP
rs188643967 1771 dbSNP
rs563025813 1776 dbSNP
rs1446233747 1777 dbSNP
rs572895609 1780 dbSNP
rs540280019 1794 dbSNP
rs140537612 1795 dbSNP
rs886045233 1795 dbSNP
rs541702640 1798 dbSNP
rs1386025542 1799 dbSNP
rs200727167 1806 dbSNP
rs1462994419 1809 dbSNP
rs1336664751 1812 dbSNP
rs1037873112 1813 dbSNP
rs759613964 1815 dbSNP
rs1374599334 1823 dbSNP
rs769824574 1824 dbSNP
rs749407404 1825 dbSNP
rs561579167 1826 dbSNP
rs945026971 1827 dbSNP
rs1043089 1829 dbSNP
rs74609163 1831 dbSNP
rs762320663 1832 dbSNP
rs1383711629 1833 dbSNP
rs1202415022 1835 dbSNP
rs1057333943 1836 dbSNP
rs1261216883 1839 dbSNP
rs924934232 1840 dbSNP
rs774246785 1841 dbSNP
rs1010661617 1842 dbSNP
rs776509863 1843 dbSNP
rs1041766965 1844 dbSNP
rs777664132 1847 dbSNP
rs1043107 1852 dbSNP
rs1184982260 1853 dbSNP
rs1421842818 1856 dbSNP
rs1429202873 1858 dbSNP
rs753831097 1860 dbSNP
rs904646966 1861 dbSNP
rs181672026 1867 dbSNP
rs763836872 1868 dbSNP
rs1243225320 1869 dbSNP
rs1337879807 1869 dbSNP
rs1464119160 1873 dbSNP
rs1488321416 1875 dbSNP
rs1344962483 1879 dbSNP
rs1428993254 1880 dbSNP
rs1290273364 1883 dbSNP
rs900372567 1895 dbSNP
rs933126234 1903 dbSNP
rs1197976570 1908 dbSNP
rs1427106696 1929 dbSNP
rs1000027922 1934 dbSNP
rs767158434 1935 dbSNP
rs763240224 1940 dbSNP
rs1178601100 1941 dbSNP
rs1406947770 1942 dbSNP
rs1453270548 1944 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccacaAUUCGGAACGAGUCUcu 5'
               |::|  | |||||||  
Target 5' ---agUGGGAGUAGCUCAGA-- 3'
 		1 - 17
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 9927.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccacaAUUCGGAACGAGUCUCu 5'
               |::|  | |||||||| 
Target 5' ---agUGGGAGUAGCUCAGAGg 3'
 		1 - 19
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 9927.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001127660 | 3UTR | GCUCAGUUACCCCUGGGCUUAGGCUGAGGCGGGCCCUGUGCUGGGGGUGGUAGAAAGGAUGCUGCUGAGGCAGCUGGAGGAGUGGGAGUAGCUCAGAGGGGAGGGCUGUUGGAUGUAUGGGGAGCUGGCAGAGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001127660 | 3UTR | GGGCUUAGGCUGAGGCGGGCCCUGUGCUGGGGGUGGUAGAAAGGAUGCUGCUGAGGCAGCUGGAGGAGUGGGAGUAGCUCAGAGGGGAGGGCUGUUGGAUGUAUGGGGAGCUGGCAGAGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001127660 | 3UTR | UGGGCUUAGGCUGAGGCGGGCCCUGUGCUGGGGGUGGUAGAAAGGAUGCUGCUGAGGCAGCUGGAGGAGUGGGAGUAGCUCAGAGGGGAGGGCUGUUGGAUGUAUGGGGAGCUGGCAGAGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001127660 | 3UTR | CUGGGCUUAGGCUGAGGCGGGCCCUGUGCUGGGGGUGGUAGAAAGGAUGCUGCUGAGGCAGCUGGAGGAGUGGGAGUAGCUCAGAGGGGAGGGCUGUUGGAUGUAUGGGGAGCUGGCAGAGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001127660 | 3UTR | GGGCUUAGGCUGAGGCGGGCCCUGUGCUGGGGGUGGUAGAAAGGAUGCUGCUGAGGCAGCUGGAGGAGUGGGAGUAGCUCAGAGGGGAGGGCUGUUGGAUGUAUGGGGAGCUGGCAGAGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001127660 | 3UTR | CGGGCCCUGUGCUGGGGGUGGUAGAAAGGAUGCUGCUGAGGCAGCUGGAGGAGUGGGAGUAGCUCAGAGGGGAGGGCUGUUGGAUGUAUGGGGAGCUGGCAGAGCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000444836.1 | 3UTR | AGUGGGAGUAGCUCAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000444836.1 | 3UTR | AGUGGGAGUAGCUCAGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000444836.1 | 3UTR | GUGGGAGUAGCUCAGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
78 hsa-miR-4653-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118186 ZNF544 zinc finger protein 544 2 2
MIRT332935 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442166 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442387 CLVS2 clavesin 2 2 2
MIRT442595 SIX1 SIX homeobox 1 2 2
MIRT448014 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448061 MMP15 matrix metallopeptidase 15 2 2
MIRT489017 C1QTNF6 C1q and TNF related 6 2 2
MIRT494456 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495650 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504016 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506777 KLHL15 kelch like family member 15 2 4
MIRT507229 FOXN2 forkhead box N2 2 4
MIRT512550 MFN2 mitofusin 2 2 6
MIRT512842 A1CF APOBEC1 complementation factor 2 6
MIRT513944 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516103 GADL1 glutamate decarboxylase like 1 2 4
MIRT519831 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523210 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525008 ACTN4 actinin alpha 4 2 6
MIRT528858 PKP1 plakophilin 1 2 2
MIRT529062 ZNF675 zinc finger protein 675 2 2
MIRT531719 TARS threonyl-tRNA synthetase 2 2
MIRT534039 STK4 serine/threonine kinase 4 2 2
MIRT543848 APIP APAF1 interacting protein 2 2
MIRT545866 ZNF264 zinc finger protein 264 2 4
MIRT556037 MXD1 MAX dimerization protein 1 2 2
MIRT557081 HOXB3 homeobox B3 2 2
MIRT561345 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562705 ZNF415 zinc finger protein 415 2 2
MIRT563223 ZNF286A zinc finger protein 286A 2 2
MIRT563860 ZNF616 zinc finger protein 616 2 4
MIRT563879 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564652 ZNF487P zinc finger protein 487 1 1
MIRT566595 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570878 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573067 TRIB1 tribbles pseudokinase 1 2 2
MIRT573941 ZNF708 zinc finger protein 708 2 2
MIRT575966 Slfn5 schlafen 5 2 5
MIRT607293 CD300E CD300e molecule 2 4
MIRT608187 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609537 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610152 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611571 SLFN5 schlafen family member 5 2 7
MIRT613335 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616560 ZNF512B zinc finger protein 512B 2 2
MIRT617240 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618011 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618478 IL17REL interleukin 17 receptor E like 2 2
MIRT619099 IFI44L interferon induced protein 44 like 2 2
MIRT622265 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623080 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625621 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627844 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630459 GMPS guanine monophosphate synthase 2 2
MIRT630524 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631502 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634537 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638807 DCTN3 dynactin subunit 3 2 2
MIRT641303 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648347 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649705 ZNF175 zinc finger protein 175 2 2
MIRT652554 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655564 P2RX7 purinergic receptor P2X 7 2 2
MIRT659065 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660341 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664330 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688934 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689971 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699514 SKIL SKI like proto-oncogene 2 2
MIRT699975 RREB1 ras responsive element binding protein 1 2 2
MIRT702676 IRS2 insulin receptor substrate 2 2 2
MIRT709357 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709837 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718716 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718879 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724105 TMEM199 transmembrane protein 199 2 2
MIRT724763 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4653-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)

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