miRTarBase - #MIRT512842


—
pre-miRNA Information
pre-miRNA hsa-mir-4653   
Genomic Coordinates chr7: 101159473 - 101159555
Description Homo sapiens miR-4653 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4653-5p
Sequence 10| UCUCUGAGCAAGGCUUAACACC |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs566953516 2 dbSNP
rs1307365749 4 dbSNP
rs1226652366 6 dbSNP
rs1216592229 12 dbSNP
rs1283699546 15 dbSNP
rs934609749 20 dbSNP
rs1377199291 21 dbSNP
rs1282994534 22 dbSNP
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B8DF7B miR-4653 Predictive Biomarker (PRD) Transcriptomic Data . . . .
Gene Information
Gene Symbol A1CF   
Synonyms ACF, ACF64, ACF65, APOBEC1CF, ASP
Description APOBEC1 complementation factor
Transcript NM_014576   
Other Transcripts NM_138932 , NM_138933   
Expression
Putative miRNA Targets on A1CF
3'UTR of A1CF
(miRNA target sites are highlighted)		 
>A1CF|NM_014576|3'UTR
   1 AGATGCTTTTTTAAATTTAAGAATAAGACACACAAAACTCTATTAAAAAAAAAAAAGAAATAAACCTCTAACTCGGTCCC
  81 CAATGATCATAAATAATATGTTTCCTAAAGAAATGCCTTTCCAGAGACTGTATAGCTTATACCAATTATAGAATCATGAA
 161 GTAAGAACGTTATTCTGAAATGAAATCAAATGTTAAAGAGCCTTTTGTTTAACAGAAAGCTGGAGAGCCACTGCCCCAAA
 241 AGTTGTTCTTCCAGTCTTCCTGAGTGTTTGGGGAGTATGTTTACAAATCCTGCCAGGGTGAAGAGAGATCTTGTAGCTGG
 321 CAAGATTTGGGAGGGATGGAGCAGACCTGGGCAGTCAGTAATAATCAAGGGAAGCCAAGTAAACTCCAGAGTCTTACCTC
 401 TGGCTCACAGCTGCTTTTGTGATACACAAAGTCACAAAGAGGAAAAGGGAAGGGAGGAGGTTGCTTTTCAAAATGCATTC
 481 ACCATGGCTCACTGTGTGGGGCATGATTGCAGGCCTGAGCTCATGAAAGACTGTCCAAGATTTTGTGGTTTCAACCTCTC
 561 TTCAGCCTGAAAATTCCATCCAGTCGATTTGTCACAGATCAGGATCTTCCTGTCCCCTGCAGCCCATGGGGACTTCCTAG
 641 AAATAGATATGATATGTTGTAGATGTGGTTAAAACAAATCCAGGCCCCATTGTTTATTCAGCTCATTAGTCCACACCTAT
 721 TTTTCCCTAGAACTCCTACCTTTTCCAATAATCATGCCAGCATGAAATGACCTTTTCTACTTTAAAATTTTTTGACTTGT
 801 TCATATTGCTTGATTTTCATCATCTCAGACTCATTTTTCTCCTACCTAATATCATAAAAAAGTAAATCAGATATACAGAA
 881 TATCATTTATGATACTTCTTCCTTTCAGCAAATTGACTGAAAAGTCATTTTAAAGAGAGAAGTGCAGATTTGCTCTCATT
 961 TCTTTGATATTGTTGCAGTATCCACCCCACCATCTAGCAATCAGAGATGCTTATATTAACTTGGGATTAGCTTTGCATTA
1041 TCTAACCCATTTATTTTAAATCTGCCAGGAAATCCTCTAACTTTCCTTCCTTTTTGTTTCAGTAAGTATCAGGCAGCTTC
1121 ACCATACCTGAGTCCTTTTGTCTTGAAGCTGCCACAGAAAAATCTTACAGCAATCATTGCTGATTAGAAACTGTTTCAGA
1201 CAATCAGCATGGGTGTTATTTACCAAATTCCCCCCAGAGTCCTAGGCCTCTTCTCCAGAAATATCTGATGATGAAGTGAG
1281 GGGAGGGCAACGGTGCTACAAAACACGGAACAGAGGTAAAGAGAAGGCACTACTTTCTTGCCATACTTGTAAATGATTGC
1361 TTTGTTCAAACATAAATAATCTTAAGTCCAACACCAAATACCTGTTACTCCTACATCAATCTCATTAGTGGTTTAAGACA
1441 CAGTACTAGAATTTTCATTTTTTAAAATCCCTTGGCCCTTAAAAAAATTTACAGAACACAAAGGAAAACATAAACACAAA
1521 GACATGGAAAATTTTGTCAACTCCTTAATGGAATTCTGTGATCAAAAAGCAGGCCAGATTCTAATCAAAATCAGGTAAAT
1601 TTTAATCACAATCAGAAGTACTTGTAACATTTCAGTTGTCCTAACTCCAATGAGATAACAAAGCCTCCAAGGCTACAGCT
1681 GAAACTCTGAAAGGCCCTGTGCTTTCTACTTTACATTTAGCGTCTAATATTTCCTAGGACAGTAGTTCCCAAAGTAGGCT
1761 GTACATTAGAATCTCCTGGAGAGCTTTTTAAATGCTAATGCCAATAACATATCTCATAAAATTTACACTAGAATTTCCTT
1841 GGATGGGTGCCTGGCATCAGTATTTTTTAATGATCCCTAGGTGATTTCAATGTGCACCTAGGTTTGGGAATTGCTATATT
1921 CTTGTATTTATACTCTATCTCTTTATTTCTTTTCCTTTTTATTTCACTTTTAGTAAATAGAAAAATGCAATTAAAAAATC
2001 ATCTAAGTTAAGACAAATAGCCAAATCATATTTATCCCATAAATAGTATGAATTTAAATGTAACTTACGTAGGCTTCAAA
2081 CTAACTCTAAAAATGAGAAAGTAAAACAATCTTGTCCTAAAACAATTCTTAGATCCAAATTTACACTCCCCTACAGATCT
2161 GCTTTTATTCTCAAAGACAGTGATTACATTGACATAACAAATGTCCATTGGGGCAGGCAAATTTCTACTGAGTCTAAAAA
2241 GCATTCCAAATTCTAGGAGCAAAAGTTCTGATTTTCCTTAAAATCTTTGCAAATAAACAGCAAAGGGTATTCTGGATGTC
2321 TTGTCAATGCAAATTAGGTTTGATTTAGAGAAGTTTTAAATTTAATCGCAATGAAAAGATTAGTTAATACATGAATCTTT
2401 TTATGAGAAAAAATCATTATTCTGGATAAAGTCATAATTGTTTGTTTACAATATTAAGAGCAGACACCTAAACATACAAT
2481 AATACCAAAGTATTGAGAAAATTACCACTGGAACACCATCTCAAGTTATCACACCATTTACCTCTTTAGAGCCAGTTTTG
2561 TATAAGTAGGTAGAAGTGGTTTTGGTTTTTTTGCTAAAATTTTACTTTGTTTTAGTAATATCTAGGGAATACTTTGAATT
2641 CCATTAAAATACCTTCATAGAAAGTGTTAATGTGTCTACCATGCCATATGTTTATTTTTACTTTCCCCAAGTTAGGTAGA
2721 TAGAGCAAGTCCTGCTACCATAAGTTTAAAATTATTAAGACAACGGGCTTTTTTAAATTGCTGGTAGAACCAAAGGCTAA
2801 TTTTGCATAGGTTTATATTTTTAGACTTAAGAAATTAGCACCTATATAATACCTTCATACCTTCTGCATCACTATCAATT
2881 TTTCTGTAATTTCTTATTTGAATGCTTCCTAATTCTTTACAGAAAAAATTAAAATTTGTCACCCAACCAGGTGATAATAA
2961 CAAAACAATAATTTAGGAACATCCAGTAAATTTGAATTAGTTCTCTAAATTTTGGTAATTAATAGCTTATTGATAATTAA
3041 AATCAGCCTAATGTTGCTTAAGTAGGAGGAAATTGATCAGCAATGGGATTGGGTATCTATTTTCTTTCCTATAAAAGTGC
3121 TGCCTCTTCTCAAATTGCTTTATTTCTCTCCCACTGCATTAGTATATCTAGAACAGCACCTTCAACTGCAACAAAATATA
3201 ATTCTCCTAGATGACTAGGATATCCTCCAATCTGGTATCATGCCAAACAACACTATGTTTGGGGAACAGCACCCGAAATG
3281 CTGCTAAAAAGCTACCTCATGTCAAGAAAATATGGATTTCAAAAAATATCTGGCACAGTGGCCCATGCCTATAACCCCAG
3361 TACTTTGGGAGGCCAAGGCAGGAGGATTGCTGGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATGGAGAGACTCCGCC
3441 TCTACAAAAAAAAAAAAAACAAATTTAATTTAATTGGCCAGTTGTGGTGGCGTGGGCCTGTGGTCCCAGCTACTTGGGAA
3521 GCTAAGGCAGGAGGATTGCTGGAGGCCTGGAGGGCAAGGCTGCAGTGAGCCATGTTCACATCGCTGCACTCCAGCCTGGG
3601 TGACAGAGCAAGACCCTGTCTCCAAAAAAGCAAAAATAAATATCTAACAAAAAGGAACCTGTTTCCAAACCACAGTTTCT
3681 TAACTTTTTCATGATGGAATAGAAATTAAACTATAAGTATATACTGATAATAGCTGTGCAGGAAATTGGTTTTTATTTTA
3761 CTTAAAAGTATTTTTTAGAAAAAATGTTATTCTGATTGCATAGATTAGCAAAATATTGCATCAATATAATGTTCCATTTT
3841 TATTAATTTTTGTTATATTCTAAATGACCGTTTTATAATTCTGTCTTGGACAACTGGGCCACAGTTAGAATCCACATAGA
3921 CAGGGAGGTTCTTAGGTGTGCCATTTGTAGAATAAAGGGCAATCAAGTTAATATTCGGGGTAAATTTTCATTGCATTCTA
4001 ACCTATGAAGTTTGATAAAGTATATTATTATTGAACAACTCTAACACTAAGATTTCCTAAAAGTAACTTACAACAAAAAA
4081 TGAACTATGTGCTCAATATTCACATAAAGTCATGATTATTCTCTTCTTGCATTCATATAAAAGTTCCCAGGGGGAAGAAA
4161 ATATATCTAAAAATTAGACTAGAAACTTGGCACTTTTTATGTATTGTAGATACACTTTCATATATTGTAAATACATCTGT
4241 TAAAGATAAAACTAAGTTTCTAACATAGCACTACAAGGAAACTTTGGATAAATATTTTTAAAAAGAAAATGTTAATAGGA
4321 TAACTTAAGATTTTGTATATACTTATTGGAAGACAGGAAGAAACTAGGCAGTAAATATTCCTACCTGACGTGCAACCATT
4401 GTCAATCAGGTTTTGTTAAACTGTCAAATTTGATTTTGAAATTTTAGTTTGCCCAAATAATATCTTGAAAATGCTCTGAA
4481 TTTTACTAGAACATATTCATAGAAAGTGTAATGTATCTACCAGGCTCTATGTTTGTGTTTGCCAACATTAGAAAAACAAA
4561 GTAAGTTGCGCTATAATGAGTGAAACTAAGGAAAATGAGATTTTTCTGACTCCCATTCCCTCTCTTAAAAAGTAAAATAT
4641 TTAAGCTTTTTTTATTAAAGGAAAAATGGGTACAGAATACTCTATTGCCCTCCAAATGTCCAACATTTTTAAAGCCATGT
4721 TGTCCAACAATGTTTATACAGAAAATAGAATGCATAGGTTTAATATAGATAGCAATGTATATGTAGGCTCATTTGTGGGA
4801 GATTGCAAACTTTATGTGCCCCCAGTTCTCCTTGGTTTTGTAGGAAAGCTAAAAGAAAACCTTGTACTCTCACTAATAAT
4881 GAAATTCATAGCCAATTTAGAAAGGGAAAATAACCTGAAAACCAAAATACCTCATTCATCTGAAGATGCCTGGAATAAAA
4961 TATGGAATTCTTCTGTACCTACCTCCCCCTTACAGACTTTTCTCCTATTTTGAGAGAGAAATTCAAGAAGAAGAATACAG
5041 CTTGTTCTCTTTCCACAAATGATACTTTGTCTAAGGGAATAGGAGATACCAAGAAACAGTATCTTTAAAAAAGTAAGCTG
5121 CCCACAGGCCTTCTTGGAGAATGAAGAATATCAGCCCCATTCAGGGTTTACCAATGTCTCTCTGAGGTGACAATACATTC
5201 TGGTTTTCCAGGACAGTCCTGGCTTAGGTCTGCTGTCCTTCTATAAATATTAACAATGATCCCTCTTATTTCCAAACGTG
5281 TCCCAGTTTAGACAACAAATTATACAGTGTCTGCCCCCAACACACACACACACACCCCACCATCTTTATGGGTTGTTGTT
5361 GTTTTCTTGTTGTTTTTAATTTTGTAGAATTGGCTTTGTCTTCTCCAAAGCAGATAACAGCTTAAACTAAAGAGCCTAGC
5441 TACTTCTTTCTGACTGAGCAGGGTCATAGTAAACAGAGAAGAATGGATCACTTCCTCCTCTGAAATCTCCATCAATCCAC
5521 TTTCTGTCCAACTATCTCTCTACCCAGCCTATTTTTGGTCCTAGTTTTCCTCTCATAACCCCTGGGCTGTGAGTCCTGAG
5601 TTCTGCCTTCATATGGCAGAGCAAGCTAGTCATTATTATGCCAGGTTAGGTGGTGGGGCAAGACAAAAGATAGCTCTTGG
5681 GGACACTTGCTTGGTCTGTAGAGATCCACAGGGCACTAGTAGGGTATTAGAGCATTTATTGGTTTCTTTCTTCCTTGAGT
5761 TGAGTTACTTCTATCCCAAAACAGACAGGTCTTACGTTAACCTTCACCTTAAAAAGGATATTGCCTTTTTTCCTTCTGCT
5841 TCACAAATTTGCTCCAACACTAATTCCCTTGCATTTGATTTCATCATTATGATTGTTCATCAACCATTCTTCACGAAAAA
5921 TCCTCACATCACGTCATATAAAGGTTTTATTATTTTTAATGGAAAATAACATTGAGAGATTATTTTCCTTTTTCATAAAA
6001 TTTCCCTTTTTCCCTCCCTCTATTCTCTTCACTAACATTGGAAATTAAACAAGTTTTACAGGCTCTATTGTTATTAACCC
6081 TCAAATCTATTCTTCAGAGAATATATGATCAGCCTGTGTTTACTATGCACCTACTCTTATACCAGAAACTGTGAATACAA
6161 ATACATATATTTCCTACTTCTCTCTTTAATTGGGGCACACAGTCCCATGGTCCATTCTGCATTTTTCAAAATTGAATATA
6241 ATTGCAACACCTGATAGGTTTTGCCACTTAGAATTCTGAAAATAAATCAACTCTGTTCTAAACCTTAAGTTTCCACTATT
6321 ATTGCCAAACTCTGGACTGATACAATAAGCCTTTTAAAAGGTGAATTTAACACTTCACCTATTATGGTTATTTAAGTAAA
6401 ATGAGTTTTCAAATATTTCCCCCAGGAGAAATATAAAGGACTATGCAAAAATAGAAGGAGAAAAAGGTTAGTTAGAGGTC
6481 CAGAAGGAGAATTAAAACATGGAATTGATAAATTCACCTACTGATTTATGATGTTAATGAGCAGGTACCTATACATTTTA
6561 TTTACTTGAAAACATTTTGGCCATTAACTATTTCTGTTTTCTAAATACATTTGTGTTTATAAAATTTTAAAATCTATATC
6641 ACAAGACTTAGACATGCCTTTCTTTGCAATAAAGTATATATACCTTTTTACAAATGTAAATTTTATTTTGAAACTTGGCA
6721 TTTTCTTTATAATTCCTAAGATATCTTTGGGCACACAGACTACAGATAAATCTATTTAAATCAATTCATCATTATCACTG
6801 GTTTAAATATTTAATGTAACCATTGGAATTTTTATTCTTATTCCTTCAGAGAATTCTCCTTTTCTTCTATGTTTCTGACT
6881 GCAATACAGCCCGATATTGTTATTCCCTATATCTTAATGAAAAGCAAGCTGTCAGCAAAATGCATTTATAGTTTCCAGAT
6961 GTTTAACAATCTCTTTCTTCTTTTCTTTTTTGTTATTATTTTTATTTATGTGAAGTTAGTTAGCTGAGGTACCAAAAAAG
7041 AGACAAAGACAGTATTAAAAAGTGTGCATAAAGCACTTATTTTTGTACTTTAGTACAATGTTTTATAGAACTTTGTGATC
7121 TATCTAAATATATTAAGTAAAATTACACCATTCACTTGTTGGGAAAATAATCTTTGGTTTGGAAGATATTAACATAATGG
7201 GCATCTTAGAATCATAAATCACATGAAATGAGAGACAATGCAATATTGTATAATTCCTGGATGATGCAATTGTTTTAATT
7281 GAATTTTCAAGTGCCATTATAAAGTTTTAAAAATTATCAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccacaaUUCGG-AACGAGUCUCu 5'
                || |: || :|||||| 
Target 5' ccctcaAATCTATTCTTCAGAGa 3'
 6078 - 6100 136.00 -10.00
2 
miRNA  3' ccACAAUUCGGAA----CGAGUCUCu 5'
            | || | :|||     :|||||| 
Target 5' aaTTTTTATTCTTATTCCTTCAGAGa 3'
 6827 - 6852 134.00 -11.10
3 
miRNA  3' ccACAAUUCGGAAC---GAGUCUcu 5'
            || ||:|::|||   ||:|||  
Target 5' ccTGATAGGTTTTGCCACTTAGAat 3'
 6250 - 6274 132.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN25750937 21 COSMIC
COSN28976235 44 COSMIC
COSN20070781 45 COSMIC
COSN23298606 45 COSMIC
COSN30179608 45 COSMIC
COSN30109772 48 COSMIC
COSN30102129 68 COSMIC
COSN30521884 68 COSMIC
COSN30465077 104 COSMIC
COSN30488457 105 COSMIC
COSN31554616 116 COSMIC
COSN5875955 202 COSMIC
COSN19199321 526 COSMIC
COSN19199269 529 COSMIC
COSN24224102 973 COSMIC
COSN17411741 1516 COSMIC
COSN16451029 1712 COSMIC
COSN10068720 2182 COSMIC
COSN4693952 2522 COSMIC
COSN15080718 2866 COSMIC
COSN1491328 3154 COSMIC
COSN21491295 3167 COSMIC
COSN1491327 3237 COSMIC
COSN27904944 3281 COSMIC
COSN15835700 3619 COSMIC
COSN17078295 3869 COSMIC
COSN20822489 3870 COSMIC
COSN173391 4199 COSMIC
COSN25873724 4300 COSMIC
COSN22606802 4389 COSMIC
COSN10068719 4449 COSMIC
COSN28459339 4480 COSMIC
COSN9210875 4702 COSMIC
COSN25992303 4769 COSMIC
COSN19451024 4877 COSMIC
COSN23117573 5320 COSMIC
COSN27992305 5325 COSMIC
COSN30254905 5821 COSMIC
COSN25763783 6232 COSMIC
COSN5875954 6564 COSMIC
COSN9210874 6615 COSMIC
COSN30006547 6705 COSMIC
COSN9028798 7091 COSMIC
COSN30056273 7131 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1413720318 1 dbSNP
rs749237292 4 dbSNP
rs777796834 6 dbSNP
rs1482509496 8 dbSNP
rs1274976413 10 dbSNP
rs1021678709 13 dbSNP
rs1408387830 13 dbSNP
rs1457101606 13 dbSNP
rs1207733247 17 dbSNP
rs1354692477 18 dbSNP
rs1284061655 20 dbSNP
rs1246193584 21 dbSNP
rs1342824684 24 dbSNP
rs755342257 27 dbSNP
rs1286508199 29 dbSNP
rs1409351817 31 dbSNP
rs1371398811 33 dbSNP
rs565415218 35 dbSNP
rs1411395327 38 dbSNP
rs371814174 42 dbSNP
rs1388341681 43 dbSNP
rs1162548137 44 dbSNP
rs1180745594 45 dbSNP
rs754200083 45 dbSNP
rs776049378 47 dbSNP
rs1370168261 48 dbSNP
rs1004219942 56 dbSNP
rs1399837240 57 dbSNP
rs1447901720 57 dbSNP
rs201036765 57 dbSNP
rs888422713 58 dbSNP
rs1367868481 71 dbSNP
rs1329826718 72 dbSNP
rs1276314663 74 dbSNP
rs1034635147 75 dbSNP
rs1433841209 79 dbSNP
rs1224824572 83 dbSNP
rs545053736 85 dbSNP
rs1048476587 103 dbSNP
rs1369677703 110 dbSNP
rs1255699971 118 dbSNP
rs1316946072 121 dbSNP
rs147876100 122 dbSNP
rs371141033 123 dbSNP
rs907409347 128 dbSNP
rs1015499231 130 dbSNP
rs542522767 135 dbSNP
rs1198146574 138 dbSNP
rs1386304016 141 dbSNP
rs1005018420 142 dbSNP
rs1012983998 143 dbSNP
rs887532898 148 dbSNP
rs1423119894 151 dbSNP
rs1466363249 155 dbSNP
rs183260900 156 dbSNP
rs747540722 162 dbSNP
rs1405287739 168 dbSNP
rs931664644 169 dbSNP
rs780388027 175 dbSNP
rs1406197602 179 dbSNP
rs1174581581 180 dbSNP
rs750699441 182 dbSNP
rs1252483338 191 dbSNP
rs1339413118 192 dbSNP
rs371566559 194 dbSNP
rs1252837234 198 dbSNP
rs1354073614 199 dbSNP
rs1209027220 201 dbSNP
rs779323278 214 dbSNP
rs1490826249 221 dbSNP
rs1040329392 225 dbSNP
rs549255835 232 dbSNP
rs1191545340 244 dbSNP
rs944611437 259 dbSNP
rs1429326317 260 dbSNP
rs1189242248 262 dbSNP
rs923844993 263 dbSNP
rs978330742 270 dbSNP
rs1457673573 275 dbSNP
rs985773172 292 dbSNP
rs1367961883 293 dbSNP
rs953148816 294 dbSNP
rs1295783996 296 dbSNP
rs374267377 300 dbSNP
rs1359405116 307 dbSNP
rs1382429909 312 dbSNP
rs61856571 313 dbSNP
rs1338350864 314 dbSNP
rs946508610 333 dbSNP
rs1313210282 337 dbSNP
rs1361463373 339 dbSNP
rs1214435118 340 dbSNP
rs1285393211 342 dbSNP
rs1486197334 350 dbSNP
rs1281145359 352 dbSNP
rs1206987736 359 dbSNP
rs746691697 375 dbSNP
rs1184561562 388 dbSNP
rs777271755 396 dbSNP
rs1387529209 406 dbSNP
rs1438366416 408 dbSNP
rs192050829 413 dbSNP
rs965891980 431 dbSNP
rs10821846 432 dbSNP
rs4619097 440 dbSNP
rs1399558671 448 dbSNP
rs780963388 452 dbSNP
rs1026967143 459 dbSNP
rs1012860866 477 dbSNP
rs894570679 480 dbSNP
rs1308370001 485 dbSNP
rs1317474559 488 dbSNP
rs377267080 490 dbSNP
rs1448653933 494 dbSNP
rs1360721731 495 dbSNP
rs972064979 497 dbSNP
rs1254382977 501 dbSNP
rs560546726 504 dbSNP
rs1002727047 507 dbSNP
rs1204610159 526 dbSNP
rs1245348017 529 dbSNP
rs1456665804 532 dbSNP
rs902984513 538 dbSNP
rs4078160 549 dbSNP
rs947314030 550 dbSNP
rs1160614375 556 dbSNP
rs914488401 557 dbSNP
rs1050123155 559 dbSNP
rs1169302561 560 dbSNP
rs1176624085 577 dbSNP
rs75583477 586 dbSNP
rs1297429252 588 dbSNP
rs887920866 591 dbSNP
rs1027391397 592 dbSNP
rs553654142 597 dbSNP
rs995866211 602 dbSNP
rs114954952 610 dbSNP
rs533274681 614 dbSNP
rs1224206044 616 dbSNP
rs1265164154 620 dbSNP
rs1186497508 629 dbSNP
rs1198363147 650 dbSNP
rs1233855872 652 dbSNP
rs1481892892 665 dbSNP
rs1190049251 690 dbSNP
rs567997849 699 dbSNP
rs1267279127 705 dbSNP
rs952998944 707 dbSNP
rs1027158166 720 dbSNP
rs1040451736 724 dbSNP
rs754083423 725 dbSNP
rs550881655 731 dbSNP
rs1169463647 740 dbSNP
rs1354956342 757 dbSNP
rs1449482141 760 dbSNP
rs187883132 761 dbSNP
rs1361384395 772 dbSNP
rs1003396299 783 dbSNP
rs903247242 788 dbSNP
rs1285309087 789 dbSNP
rs754956147 791 dbSNP
rs1020575090 794 dbSNP
rs753578993 794 dbSNP
rs902446617 803 dbSNP
rs1274132930 804 dbSNP
rs747166325 809 dbSNP
rs1309564854 814 dbSNP
rs1042278266 831 dbSNP
rs1219844896 839 dbSNP
rs1265323104 839 dbSNP
rs1011402600 845 dbSNP
rs1222548427 849 dbSNP
rs946561067 857 dbSNP
rs183510764 863 dbSNP
rs546857932 865 dbSNP
rs551869430 866 dbSNP
rs1419791478 876 dbSNP
rs1430019275 889 dbSNP
rs766190079 891 dbSNP
rs1339531495 893 dbSNP
rs1364839033 900 dbSNP
rs528429925 901 dbSNP
rs559326068 907 dbSNP
rs564221585 926 dbSNP
rs1358764529 938 dbSNP
rs1430112567 940 dbSNP
rs1270935283 952 dbSNP
rs915059695 953 dbSNP
rs990273018 957 dbSNP
rs1314845104 961 dbSNP
rs542659838 964 dbSNP
rs1225445477 970 dbSNP
rs189792766 972 dbSNP
rs563628664 976 dbSNP
rs1486982286 978 dbSNP
rs931656875 981 dbSNP
rs543223149 982 dbSNP
rs1242286493 986 dbSNP
rs544439004 990 dbSNP
rs937401012 991 dbSNP
rs1228847123 1006 dbSNP
rs1384433464 1015 dbSNP
rs927367617 1021 dbSNP
rs1381188140 1024 dbSNP
rs374062727 1025 dbSNP
rs1400143420 1029 dbSNP
rs563983021 1031 dbSNP
rs940460384 1034 dbSNP
rs1282223315 1038 dbSNP
rs1336474588 1040 dbSNP
rs1384083769 1048 dbSNP
rs1248633712 1049 dbSNP
rs1307631875 1055 dbSNP
rs575424958 1058 dbSNP
rs1222664295 1062 dbSNP
rs983362053 1066 dbSNP
rs1201450793 1075 dbSNP
rs1242293651 1078 dbSNP
rs1461558646 1081 dbSNP
rs908135031 1086 dbSNP
rs1185223417 1087 dbSNP
rs1236245503 1092 dbSNP
rs1370935013 1109 dbSNP
rs185182715 1112 dbSNP
rs952240206 1114 dbSNP
rs144955107 1116 dbSNP
rs1431834999 1124 dbSNP
rs920196184 1131 dbSNP
rs991672476 1139 dbSNP
rs1412980520 1145 dbSNP
rs1169779257 1152 dbSNP
rs958932439 1163 dbSNP
rs555390100 1168 dbSNP
rs535480718 1178 dbSNP
rs1454868639 1182 dbSNP
rs1329762391 1191 dbSNP
rs996264284 1193 dbSNP
rs574368650 1198 dbSNP
rs1279618710 1199 dbSNP
rs557658455 1203 dbSNP
rs370866633 1209 dbSNP
rs377678162 1212 dbSNP
rs902163173 1217 dbSNP
rs1262071628 1223 dbSNP
rs1042351282 1229 dbSNP
rs567105107 1230 dbSNP
rs1205296057 1231 dbSNP
rs1206915531 1236 dbSNP
rs1010825875 1241 dbSNP
rs1437154636 1248 dbSNP
rs1011829459 1249 dbSNP
rs141008906 1257 dbSNP
rs1234538932 1269 dbSNP
rs1479429558 1270 dbSNP
rs767833377 1277 dbSNP
rs1250288692 1282 dbSNP
rs147317265 1291 dbSNP
rs144018747 1292 dbSNP
rs1291434924 1295 dbSNP
rs937821785 1298 dbSNP
rs1168950694 1306 dbSNP
rs115620402 1307 dbSNP
rs180901016 1315 dbSNP
rs1329869394 1321 dbSNP
rs901743963 1335 dbSNP
rs1040484214 1343 dbSNP
rs940333752 1345 dbSNP
rs370818217 1349 dbSNP
rs1045790054 1355 dbSNP
rs748150588 1357 dbSNP
rs764490128 1366 dbSNP
rs1048780255 1375 dbSNP
rs1274965178 1399 dbSNP
rs1489847489 1403 dbSNP
rs4480485 1411 dbSNP
rs907853763 1423 dbSNP
rs191009467 1424 dbSNP
rs556681289 1424 dbSNP
rs1191385989 1429 dbSNP
rs779511900 1431 dbSNP
rs763579100 1435 dbSNP
rs974899209 1464 dbSNP
rs1170039686 1468 dbSNP
rs964877451 1470 dbSNP
rs529271603 1481 dbSNP
rs186717588 1485 dbSNP
rs1301976592 1487 dbSNP
rs1461360411 1488 dbSNP
rs967367584 1491 dbSNP
rs542516936 1504 dbSNP
rs1379519662 1506 dbSNP
rs913327754 1523 dbSNP
rs966817570 1530 dbSNP
rs1416952033 1532 dbSNP
rs1020625570 1533 dbSNP
rs1249293837 1534 dbSNP
rs1191407473 1536 dbSNP
rs1489208443 1542 dbSNP
rs1357158418 1543 dbSNP
rs4554830 1544 dbSNP
rs893731655 1549 dbSNP
rs1182209931 1558 dbSNP
rs1055025716 1562 dbSNP
rs1292583326 1576 dbSNP
rs1490841237 1585 dbSNP
rs550058116 1587 dbSNP
rs1261240022 1601 dbSNP
rs1213032920 1614 dbSNP
rs1028854466 1623 dbSNP
rs1329733350 1633 dbSNP
rs996008440 1634 dbSNP
rs1444560868 1637 dbSNP
rs1236542113 1645 dbSNP
rs1387652037 1647 dbSNP
rs1458953489 1648 dbSNP
rs375897906 1650 dbSNP
rs532934704 1651 dbSNP
rs1383750211 1655 dbSNP
rs1046260225 1659 dbSNP
rs1380392181 1671 dbSNP
rs770289439 1676 dbSNP
rs1315576998 1682 dbSNP
rs1004973853 1696 dbSNP
rs1373353616 1701 dbSNP
rs1323939888 1703 dbSNP
rs907929956 1705 dbSNP
rs1389942862 1708 dbSNP
rs1161827272 1718 dbSNP
rs1351659691 1719 dbSNP
rs74874346 1721 dbSNP
rs541265731 1722 dbSNP
rs1461106016 1725 dbSNP
rs1176397793 1738 dbSNP
rs994566748 1742 dbSNP
rs772726270 1745 dbSNP
rs1156280524 1758 dbSNP
rs1055921379 1771 dbSNP
rs771797387 1802 dbSNP
rs937474336 1811 dbSNP
rs1192410264 1816 dbSNP
rs35839127 1837 dbSNP
rs1403453723 1839 dbSNP
rs1451582865 1847 dbSNP
rs1337182202 1862 dbSNP
rs572153349 1864 dbSNP
rs1249740795 1868 dbSNP
rs1389661044 1879 dbSNP
rs1306382320 1880 dbSNP
rs1336359281 1883 dbSNP
rs1203314906 1898 dbSNP
rs1045961016 1901 dbSNP
rs1261447213 1902 dbSNP
rs946053598 1908 dbSNP
rs943556337 1913 dbSNP
rs912061765 1914 dbSNP
rs1349764902 1928 dbSNP
rs1256350146 1929 dbSNP
rs1204672289 1941 dbSNP
rs1265436875 1950 dbSNP
rs913261119 1961 dbSNP
rs80080606 1965 dbSNP
rs1419089822 1974 dbSNP
rs1350260298 1978 dbSNP
rs1426720480 1986 dbSNP
rs1469014268 1989 dbSNP
rs1301353038 1997 dbSNP
rs957483162 1998 dbSNP
rs1233568385 1999 dbSNP
rs1460282925 2005 dbSNP
rs1297482593 2013 dbSNP
rs966494548 2018 dbSNP
rs1397158075 2029 dbSNP
rs541821379 2046 dbSNP
rs1281504211 2050 dbSNP
rs1345092909 2056 dbSNP
rs4619096 2068 dbSNP
rs974575146 2069 dbSNP
rs957664175 2075 dbSNP
rs1204281680 2079 dbSNP
rs965882387 2093 dbSNP
rs1384748072 2094 dbSNP
rs1303748082 2098 dbSNP
rs778506303 2108 dbSNP
rs1481924937 2111 dbSNP
rs1467282568 2120 dbSNP
rs1266224165 2135 dbSNP
rs1019292048 2146 dbSNP
rs1199612364 2148 dbSNP
rs1426847500 2151 dbSNP
rs1392815923 2152 dbSNP
rs1033626249 2157 dbSNP
rs1449617378 2161 dbSNP
rs1391473808 2187 dbSNP
rs1004831478 2196 dbSNP
rs1002110228 2198 dbSNP
rs1027313769 2199 dbSNP
rs994453191 2201 dbSNP
rs1256636390 2207 dbSNP
rs1365106227 2208 dbSNP
rs557332031 2210 dbSNP
rs1201904538 2219 dbSNP
rs1405631521 2244 dbSNP
rs1486777681 2250 dbSNP
rs1360160804 2265 dbSNP
rs1214310297 2268 dbSNP
rs1296792345 2271 dbSNP
rs894905754 2282 dbSNP
rs1278535490 2285 dbSNP
rs1210419708 2292 dbSNP
rs1291698107 2293 dbSNP
rs1054765028 2299 dbSNP
rs1002130422 2300 dbSNP
rs1343023954 2306 dbSNP
rs796649733 2309 dbSNP
rs1248056408 2310 dbSNP
rs1484714042 2318 dbSNP
rs1024803166 2319 dbSNP
rs1046308937 2321 dbSNP
rs1004411390 2322 dbSNP
rs768537980 2323 dbSNP
rs946343084 2336 dbSNP
rs1384545290 2344 dbSNP
rs1047773842 2350 dbSNP
rs537753887 2367 dbSNP
rs899152464 2368 dbSNP
rs1289812763 2371 dbSNP
rs1367715315 2372 dbSNP
rs1450931961 2373 dbSNP
rs1039732133 2378 dbSNP
rs1360835626 2382 dbSNP
rs935954474 2388 dbSNP
rs1291470603 2390 dbSNP
rs1314746452 2396 dbSNP
rs578221646 2397 dbSNP
rs943624945 2402 dbSNP
rs1429979554 2405 dbSNP
rs397822386 2414 dbSNP
rs398075139 2414 dbSNP
rs56060492 2414 dbSNP
rs912096990 2417 dbSNP
rs150545950 2424 dbSNP
rs1368913426 2434 dbSNP
rs779763020 2445 dbSNP
rs1405968951 2448 dbSNP
rs913667300 2450 dbSNP
rs1160033257 2451 dbSNP
rs911752932 2457 dbSNP
rs989218344 2460 dbSNP
rs181705018 2461 dbSNP
rs141679552 2467 dbSNP
rs1336534495 2468 dbSNP
rs983685115 2478 dbSNP
rs1450896669 2486 dbSNP
rs1189523730 2487 dbSNP
rs1033346175 2488 dbSNP
rs950695553 2508 dbSNP
rs1285440096 2518 dbSNP
rs981133583 2523 dbSNP
rs970671817 2526 dbSNP
rs1351772187 2527 dbSNP
rs1222716010 2531 dbSNP
rs1025286018 2552 dbSNP
rs1027492826 2554 dbSNP
rs1474134399 2562 dbSNP
rs1256514028 2566 dbSNP
rs1201503855 2580 dbSNP
rs112824128 2585 dbSNP
rs1442922682 2589 dbSNP
rs1231119939 2591 dbSNP
rs1483480979 2593 dbSNP
rs1469648391 2594 dbSNP
rs886927919 2611 dbSNP
rs750303736 2612 dbSNP
rs1026379205 2614 dbSNP
rs1414431029 2621 dbSNP
rs781243061 2627 dbSNP
rs1407379895 2639 dbSNP
rs759503859 2639 dbSNP
rs1339314893 2640 dbSNP
rs546894300 2641 dbSNP
rs899206500 2643 dbSNP
rs1416519181 2651 dbSNP
rs1039042680 2660 dbSNP
rs751187910 2661 dbSNP
rs1440781121 2666 dbSNP
rs890732140 2675 dbSNP
rs1288472057 2680 dbSNP
rs1052420270 2681 dbSNP
rs147988232 2683 dbSNP
rs1003325286 2689 dbSNP
rs914056430 2690 dbSNP
rs1282247759 2696 dbSNP
rs1410090762 2705 dbSNP
rs115550940 2707 dbSNP
rs1270751833 2715 dbSNP
rs936400630 2719 dbSNP
rs1010813787 2720 dbSNP
rs926334164 2721 dbSNP
rs1254148550 2734 dbSNP
rs1489921088 2738 dbSNP
rs1054688081 2740 dbSNP
rs935998778 2741 dbSNP
rs980479274 2759 dbSNP
rs184644838 2764 dbSNP
rs533243777 2765 dbSNP
rs1411063146 2768 dbSNP
rs1308097063 2778 dbSNP
rs181769526 2782 dbSNP
rs1402573962 2784 dbSNP
rs1302089021 2792 dbSNP
rs951254796 2794 dbSNP
rs1331360395 2797 dbSNP
rs1235107034 2805 dbSNP
rs540100858 2836 dbSNP
rs1268252149 2839 dbSNP
rs983310814 2841 dbSNP
rs929090283 2842 dbSNP
rs1026766865 2844 dbSNP
rs995266747 2851 dbSNP
rs1234751270 2854 dbSNP
rs963433814 2882 dbSNP
rs1179924837 2896 dbSNP
rs1221867709 2913 dbSNP
rs1268264436 2925 dbSNP
rs1453582223 2936 dbSNP
rs1191459586 2938 dbSNP
rs1437376609 2947 dbSNP
rs920531228 2948 dbSNP
rs1450633664 2956 dbSNP
rs1018082185 2966 dbSNP
rs571063734 2976 dbSNP
rs763487949 2977 dbSNP
rs1333282815 2980 dbSNP
rs569037857 2982 dbSNP
rs1162418094 2985 dbSNP
rs959270875 2986 dbSNP
rs1272974067 2990 dbSNP
rs1033331364 2999 dbSNP
rs1009821239 3002 dbSNP
rs189405183 3016 dbSNP
rs970537888 3022 dbSNP
rs1299673867 3032 dbSNP
rs1277465671 3037 dbSNP
rs892675210 3049 dbSNP
rs753271545 3057 dbSNP
rs936797637 3061 dbSNP
rs926404111 3062 dbSNP
rs891939844 3072 dbSNP
rs1033165363 3073 dbSNP
rs1465589978 3083 dbSNP
rs1045200311 3092 dbSNP
rs765902824 3094 dbSNP
rs1190943334 3095 dbSNP
rs1241801653 3099 dbSNP
rs1444612762 3103 dbSNP
rs949102690 3109 dbSNP
rs183470005 3110 dbSNP
rs982696931 3112 dbSNP
rs1156393162 3114 dbSNP
rs1383823839 3121 dbSNP
rs541958292 3131 dbSNP
rs951307228 3136 dbSNP
rs934352847 3137 dbSNP
rs16909156 3144 dbSNP
rs1380464168 3152 dbSNP
rs1451900222 3161 dbSNP
rs562501851 3167 dbSNP
rs964190603 3174 dbSNP
rs1157098361 3176 dbSNP
rs1469793481 3180 dbSNP
rs1237001748 3191 dbSNP
rs1395807917 3198 dbSNP
rs1260321528 3211 dbSNP
rs10994532 3215 dbSNP
rs890546719 3225 dbSNP
rs1195530406 3235 dbSNP
rs1048250770 3237 dbSNP
rs1467539729 3240 dbSNP
rs929156098 3241 dbSNP
rs1461258239 3244 dbSNP
rs759947685 3245 dbSNP
rs1252994741 3251 dbSNP
rs1017718715 3253 dbSNP
rs1008039815 3255 dbSNP
rs920459540 3257 dbSNP
rs1258884526 3259 dbSNP
rs1209890874 3263 dbSNP
rs545522382 3264 dbSNP
rs145223716 3274 dbSNP
rs35022618 3275 dbSNP
rs777102114 3275 dbSNP
rs1009538918 3278 dbSNP
rs892727671 3280 dbSNP
rs1345225692 3281 dbSNP
rs16751 3293 dbSNP
rs1001060281 3311 dbSNP
rs926534364 3313 dbSNP
rs1369608762 3328 dbSNP
rs905339095 3334 dbSNP
rs1303300166 3336 dbSNP
rs141492927 3338 dbSNP
rs970760506 3340 dbSNP
rs572313468 3342 dbSNP
rs949149824 3343 dbSNP
rs555394887 3357 dbSNP
rs1351324724 3360 dbSNP
rs896202743 3367 dbSNP
rs1343257841 3379 dbSNP
rs373776745 3381 dbSNP
rs1046716709 3387 dbSNP
rs988324623 3399 dbSNP
rs1400369152 3403 dbSNP
rs1395861157 3404 dbSNP
rs929620771 3409 dbSNP
rs1258246799 3411 dbSNP
rs957755450 3415 dbSNP
rs1175750124 3418 dbSNP
rs535939681 3428 dbSNP
rs1043238028 3435 dbSNP
rs1452720070 3437 dbSNP
rs4282939 3438 dbSNP
rs1187654034 3439 dbSNP
rs1476651474 3442 dbSNP
rs1240741152 3443 dbSNP
rs1215441304 3444 dbSNP
rs75745987 3445 dbSNP
rs368412902 3446 dbSNP
rs1000355470 3450 dbSNP
rs964964714 3456 dbSNP
rs1018234186 3457 dbSNP
rs1460453355 3457 dbSNP
rs1371168170 3458 dbSNP
rs1282101380 3459 dbSNP
rs1008917411 3460 dbSNP
rs11421997 3460 dbSNP
rs1301467678 3460 dbSNP
rs534233792 3460 dbSNP
rs754917415 3460 dbSNP
rs1208265464 3461 dbSNP
rs1227430474 3462 dbSNP
rs1346587894 3462 dbSNP
rs1275983110 3463 dbSNP
rs1342181644 3464 dbSNP
rs1206711008 3467 dbSNP
rs1297655648 3476 dbSNP
rs1487981793 3477 dbSNP
rs973948627 3478 dbSNP
rs1269281031 3479 dbSNP
rs942573419 3480 dbSNP
rs1216292363 3486 dbSNP
rs1344203993 3488 dbSNP
rs1390731526 3489 dbSNP
rs556502924 3491 dbSNP
rs539474542 3492 dbSNP
rs911044446 3496 dbSNP
rs1448403406 3503 dbSNP
rs1047711002 3511 dbSNP
rs1349497715 3526 dbSNP
rs986268400 3527 dbSNP
rs993566919 3531 dbSNP
rs1315065558 3533 dbSNP
rs899253846 3537 dbSNP
rs1434844709 3546 dbSNP
rs1037534407 3548 dbSNP
rs1368022208 3551 dbSNP
rs1229945916 3555 dbSNP
rs954580807 3563 dbSNP
rs954968981 3565 dbSNP
rs1030383706 3567 dbSNP
rs937814478 3582 dbSNP
rs370137125 3583 dbSNP
rs1412144060 3587 dbSNP
rs1417908006 3589 dbSNP
rs1186440242 3597 dbSNP
rs1475772449 3601 dbSNP
rs768165398 3605 dbSNP
rs748851183 3606 dbSNP
rs913579817 3607 dbSNP
rs1485118265 3609 dbSNP
rs1001520438 3610 dbSNP
rs987820446 3616 dbSNP
rs905392474 3618 dbSNP
rs1251409619 3624 dbSNP
rs1321702402 3630 dbSNP
rs1024229906 3650 dbSNP
rs1451180851 3652 dbSNP
rs1205942741 3657 dbSNP
rs1305702900 3658 dbSNP
rs1013714869 3675 dbSNP
rs1228792750 3680 dbSNP
rs138770648 3700 dbSNP
rs1046770290 3702 dbSNP
rs1228416600 3711 dbSNP
rs774832419 3731 dbSNP
rs1314377061 3734 dbSNP
rs929674470 3736 dbSNP
rs1291163843 3738 dbSNP
rs964850136 3739 dbSNP
rs1413191346 3748 dbSNP
rs1406897357 3773 dbSNP
rs1354992579 3779 dbSNP
rs547828940 3785 dbSNP
rs765227476 3789 dbSNP
rs527444388 3816 dbSNP
rs1201620874 3819 dbSNP
rs1236851814 3827 dbSNP
rs779959067 3831 dbSNP
rs1473139388 3847 dbSNP
rs1183704193 3852 dbSNP
rs954966285 3856 dbSNP
rs1160359939 3859 dbSNP
rs898149319 3860 dbSNP
rs1038290774 3866 dbSNP
rs942606389 3869 dbSNP
rs911108913 3870 dbSNP
rs1170420562 3881 dbSNP
rs993452319 3881 dbSNP
rs987043705 3887 dbSNP
rs933819282 3891 dbSNP
rs1304131347 3894 dbSNP
rs1348230805 3899 dbSNP
rs1227477851 3905 dbSNP
rs1288596931 3910 dbSNP
rs923376448 3915 dbSNP
rs1462399387 3923 dbSNP
rs1277780621 3927 dbSNP
rs1442977715 3928 dbSNP
rs1212318988 3932 dbSNP
rs1231317679 3938 dbSNP
rs1420517446 3939 dbSNP
rs899265629 3945 dbSNP
rs1163169560 3947 dbSNP
rs1183093601 3948 dbSNP
rs988204021 3960 dbSNP
rs1016265910 3968 dbSNP
rs1479636939 3970 dbSNP
rs1046209099 3975 dbSNP
rs568267580 3976 dbSNP
rs192736534 3977 dbSNP
rs531425767 3980 dbSNP
rs1408703821 3981 dbSNP
rs1479397868 3981 dbSNP
rs189535128 3988 dbSNP
rs1351981655 3989 dbSNP
rs979421744 4003 dbSNP
rs185072229 4006 dbSNP
rs1345622647 4010 dbSNP
rs1220810283 4011 dbSNP
rs970046608 4020 dbSNP
rs1341483058 4021 dbSNP
rs1214277055 4023 dbSNP
rs1205992090 4031 dbSNP
rs1023865617 4042 dbSNP
rs200309842 4046 dbSNP
rs10534726 4051 dbSNP
rs144720237 4051 dbSNP
rs757453810 4051 dbSNP
rs1014184879 4055 dbSNP
rs1232380554 4061 dbSNP
rs532204492 4065 dbSNP
rs1166608239 4069 dbSNP
rs1390127581 4071 dbSNP
rs1428497110 4075 dbSNP
rs1308048166 4081 dbSNP
rs960848566 4087 dbSNP
rs200517726 4088 dbSNP
rs1264072150 4099 dbSNP
rs1403313067 4103 dbSNP
rs1195912123 4104 dbSNP
rs1322480322 4106 dbSNP
rs1331411566 4121 dbSNP
rs1025371815 4124 dbSNP
rs993876272 4128 dbSNP
rs1229198023 4150 dbSNP
rs898201772 4150 dbSNP
rs1354505927 4152 dbSNP
rs1209398456 4154 dbSNP
rs1290881672 4160 dbSNP
rs1371329756 4163 dbSNP
rs1187102345 4167 dbSNP
rs1297644499 4168 dbSNP
rs149088214 4173 dbSNP
rs1450694632 4178 dbSNP
rs1442314513 4193 dbSNP
rs1397256058 4194 dbSNP
rs975129700 4195 dbSNP
rs1471531293 4210 dbSNP
rs942452793 4215 dbSNP
rs1162228464 4219 dbSNP
rs192865589 4221 dbSNP
rs1324309579 4225 dbSNP
rs549384923 4226 dbSNP
rs1461314175 4227 dbSNP
rs1406842236 4234 dbSNP
rs1318348282 4245 dbSNP
rs747216594 4251 dbSNP
rs1038010437 4252 dbSNP
rs1160884337 4264 dbSNP
rs1006520441 4266 dbSNP
rs987655285 4267 dbSNP
rs1299742492 4268 dbSNP
rs1338721451 4270 dbSNP
rs1416895343 4297 dbSNP
rs547003448 4305 dbSNP
rs1284961843 4309 dbSNP
rs545755151 4314 dbSNP
rs772148853 4316 dbSNP
rs1406632686 4319 dbSNP
rs955165042 4325 dbSNP
rs1267959215 4330 dbSNP
rs889722532 4335 dbSNP
rs1211060808 4337 dbSNP
rs1193649243 4340 dbSNP
rs1469767478 4342 dbSNP
rs532026231 4345 dbSNP
rs1212975395 4346 dbSNP
rs769767018 4350 dbSNP
rs1368658266 4358 dbSNP
rs375129305 4361 dbSNP
rs913065485 4369 dbSNP
rs1156675355 4384 dbSNP
rs138030289 4389 dbSNP
rs150441974 4390 dbSNP
rs781065153 4391 dbSNP
rs1400024030 4396 dbSNP
rs376351175 4397 dbSNP
rs1342475109 4398 dbSNP
rs1226729030 4401 dbSNP
rs1287977269 4405 dbSNP
rs371949547 4410 dbSNP
rs979860010 4416 dbSNP
rs1373286898 4424 dbSNP
rs905272701 4427 dbSNP
rs1254734494 4438 dbSNP
rs755552918 4440 dbSNP
rs1324542857 4447 dbSNP
rs371032681 4455 dbSNP
rs570653825 4462 dbSNP
rs1386166915 4463 dbSNP
rs916846076 4464 dbSNP
rs1179500656 4465 dbSNP
rs1250650198 4472 dbSNP
rs550659290 4489 dbSNP
rs1472775040 4493 dbSNP
rs1161072309 4496 dbSNP
rs572450377 4497 dbSNP
rs1375837589 4512 dbSNP
rs992404765 4513 dbSNP
rs1173231702 4518 dbSNP
rs892379711 4527 dbSNP
rs1408100336 4529 dbSNP
rs1344168817 4533 dbSNP
rs140487683 4535 dbSNP
rs1351378842 4542 dbSNP
rs1412035953 4546 dbSNP
rs369298308 4553 dbSNP
rs1025762033 4557 dbSNP
rs994263533 4563 dbSNP
rs1392697617 4565 dbSNP
rs962440791 4569 dbSNP
rs12571156 4570 dbSNP
rs1263614456 4576 dbSNP
rs1202454591 4601 dbSNP
rs751812050 4601 dbSNP
rs1250579105 4619 dbSNP
rs147886350 4620 dbSNP
rs988053238 4624 dbSNP
rs1265088270 4632 dbSNP
rs1432397681 4643 dbSNP
rs1199424240 4645 dbSNP
rs889438699 4647 dbSNP
rs1396845976 4654 dbSNP
rs7072584 4660 dbSNP
rs1285665346 4669 dbSNP
rs1211858101 4683 dbSNP
rs187640338 4684 dbSNP
rs74352101 4686 dbSNP
rs972262123 4687 dbSNP
rs1292002729 4689 dbSNP
rs183095006 4690 dbSNP
rs1387734722 4695 dbSNP
rs1306224047 4698 dbSNP
rs1233183922 4699 dbSNP
rs1052948649 4704 dbSNP
rs1327468678 4713 dbSNP
rs1225516875 4715 dbSNP
rs1273359188 4717 dbSNP
rs1342429541 4719 dbSNP
rs1298189770 4722 dbSNP
rs61383648 4724 dbSNP
rs935792056 4724 dbSNP
rs1263336057 4728 dbSNP
rs1380949054 4765 dbSNP
rs1016256252 4771 dbSNP
rs925376999 4772 dbSNP
rs750736036 4782 dbSNP
rs1447641486 4783 dbSNP
rs1390787870 4786 dbSNP
rs948078354 4790 dbSNP
rs1162887933 4792 dbSNP
rs1349551479 4794 dbSNP
rs916576850 4803 dbSNP
rs992858874 4809 dbSNP
rs1458709191 4810 dbSNP
rs1328407194 4817 dbSNP
rs1387074140 4818 dbSNP
rs1373125492 4819 dbSNP
rs1172423335 4821 dbSNP
rs1013855091 4824 dbSNP
rs1374659691 4829 dbSNP
rs1361976735 4835 dbSNP
rs956536672 4839 dbSNP
rs1310096467 4843 dbSNP
rs1245223801 4844 dbSNP
rs59030524 4846 dbSNP
rs1000808491 4848 dbSNP
rs1486868504 4851 dbSNP
rs1427767352 4860 dbSNP
rs1257943934 4862 dbSNP
rs75842905 4865 dbSNP
rs972886080 4878 dbSNP
rs962825944 4879 dbSNP
rs1017126232 4903 dbSNP
rs757983800 4904 dbSNP
rs1410134167 4905 dbSNP
rs1457059393 4906 dbSNP
rs796832739 4914 dbSNP
rs1486745967 4920 dbSNP
rs1321760874 4921 dbSNP
rs890874581 4930 dbSNP
rs1432260888 4931 dbSNP
rs752312079 4937 dbSNP
rs548389442 4945 dbSNP
rs1377976291 4949 dbSNP
rs1233443661 4953 dbSNP
rs1294757008 4961 dbSNP
rs755530938 4974 dbSNP
rs531434034 4988 dbSNP
rs1253654490 4990 dbSNP
rs1225847283 4997 dbSNP
rs997819167 5013 dbSNP
rs891730977 5025 dbSNP
rs867670320 5027 dbSNP
rs1483623036 5036 dbSNP
rs28450710 5036 dbSNP
rs1249919215 5038 dbSNP
rs1317734229 5039 dbSNP
rs1472450342 5045 dbSNP
rs754111199 5048 dbSNP
rs1160433585 5049 dbSNP
rs1410784889 5059 dbSNP
rs559780104 5063 dbSNP
rs1036484353 5065 dbSNP
rs1414889145 5067 dbSNP
rs192436023 5076 dbSNP
rs904343463 5080 dbSNP
rs1044232046 5085 dbSNP
rs187924607 5087 dbSNP
rs981181097 5088 dbSNP
rs1397996797 5089 dbSNP
rs1375439284 5090 dbSNP
rs1166141154 5093 dbSNP
rs1217339484 5097 dbSNP
rs1277849067 5097 dbSNP
rs895180509 5098 dbSNP
rs774036729 5101 dbSNP
rs1056397231 5102 dbSNP
rs1465013092 5105 dbSNP
rs939325273 5109 dbSNP
rs1418329854 5121 dbSNP
rs1166750434 5124 dbSNP
rs969392339 5125 dbSNP
rs1482885037 5138 dbSNP
rs1183344901 5142 dbSNP
rs1255753890 5157 dbSNP
rs1234886997 5163 dbSNP
rs986012264 5165 dbSNP
rs1191072457 5172 dbSNP
rs1426520739 5178 dbSNP
rs763799492 5186 dbSNP
rs1187089171 5189 dbSNP
rs918856055 5191 dbSNP
rs540270766 5193 dbSNP
rs1368307363 5197 dbSNP
rs1194620269 5202 dbSNP
rs1030880337 5209 dbSNP
rs1337251040 5211 dbSNP
rs1434059605 5227 dbSNP
rs532082870 5235 dbSNP
rs115068752 5238 dbSNP
rs1274214420 5243 dbSNP
rs1371699304 5258 dbSNP
rs1236569538 5269 dbSNP
rs762422407 5277 dbSNP
rs1341546086 5295 dbSNP
rs1196541078 5298 dbSNP
rs1275407280 5301 dbSNP
rs1018164829 5311 dbSNP
rs1221350998 5314 dbSNP
rs1254154640 5320 dbSNP
rs1456013578 5327 dbSNP
rs12259425 5334 dbSNP
rs1239291514 5335 dbSNP
rs1398225267 5336 dbSNP
rs148220589 5336 dbSNP
rs749294194 5336 dbSNP
rs993957101 5336 dbSNP
rs1233271265 5341 dbSNP
rs953829814 5344 dbSNP
rs1395120445 5346 dbSNP
rs1337062902 5347 dbSNP
rs896899574 5353 dbSNP
rs1318472359 5359 dbSNP
rs1036494142 5365 dbSNP
rs942161812 5367 dbSNP
rs527962380 5369 dbSNP
rs1228095545 5371 dbSNP
rs1445967118 5372 dbSNP
rs1395036726 5378 dbSNP
rs1470110567 5384 dbSNP
rs1029799294 5388 dbSNP
rs1247979565 5390 dbSNP
rs1445880323 5393 dbSNP
rs759499044 5395 dbSNP
rs1193332828 5413 dbSNP
rs976434321 5414 dbSNP
rs562070276 5415 dbSNP
rs1045292340 5430 dbSNP
rs1319184232 5433 dbSNP
rs745852162 5438 dbSNP
rs1163760422 5446 dbSNP
rs1418234809 5452 dbSNP
rs948290006 5453 dbSNP
rs955673906 5461 dbSNP
rs1031622060 5462 dbSNP
rs956810879 5479 dbSNP
rs1412769775 5484 dbSNP
rs1000105385 5486 dbSNP
rs904393471 5487 dbSNP
rs191203010 5493 dbSNP
rs1447489326 5501 dbSNP
rs1162928672 5515 dbSNP
rs576578860 5518 dbSNP
rs144636471 5523 dbSNP
rs1013128352 5532 dbSNP
rs1268023673 5541 dbSNP
rs979262691 5548 dbSNP
rs1365627892 5559 dbSNP
rs545986609 5560 dbSNP
rs1440204467 5564 dbSNP
rs1186719090 5583 dbSNP
rs967851651 5602 dbSNP
rs577462784 5605 dbSNP
rs1156742495 5611 dbSNP
rs1363145505 5614 dbSNP
rs776223415 5627 dbSNP
rs1400086615 5629 dbSNP
rs1414003953 5630 dbSNP
rs186253502 5636 dbSNP
rs776502645 5640 dbSNP
rs1018623632 5642 dbSNP
rs897156464 5643 dbSNP
rs1037287672 5650 dbSNP
rs955454981 5651 dbSNP
rs1289580607 5652 dbSNP
rs1288188631 5653 dbSNP
rs1336726575 5661 dbSNP
rs941625598 5669 dbSNP
rs1254787275 5671 dbSNP
rs1342208366 5674 dbSNP
rs1352316028 5684 dbSNP
rs386743637 5687 dbSNP
rs1280568869 5694 dbSNP
rs1029362301 5697 dbSNP
rs534222118 5699 dbSNP
rs1179744368 5701 dbSNP
rs577707642 5705 dbSNP
rs993758526 5719 dbSNP
rs183404703 5730 dbSNP
rs896909391 5731 dbSNP
rs1183845229 5732 dbSNP
rs1375892284 5736 dbSNP
rs1434154250 5745 dbSNP
rs1016613257 5748 dbSNP
rs1377495888 5756 dbSNP
rs1006358026 5757 dbSNP
rs142328929 5758 dbSNP
rs538003290 5761 dbSNP
rs1393532048 5764 dbSNP
rs1371072924 5768 dbSNP
rs190163409 5771 dbSNP
rs770775561 5772 dbSNP
rs1438585299 5775 dbSNP
rs185753081 5781 dbSNP
rs1232908679 5784 dbSNP
rs374984128 5788 dbSNP
rs147746879 5795 dbSNP
rs142968717 5796 dbSNP
rs1157078814 5801 dbSNP
rs896723703 5806 dbSNP
rs1439229565 5816 dbSNP
rs976484844 5817 dbSNP
rs1480816450 5821 dbSNP
rs1395745908 5825 dbSNP
rs1197382184 5827 dbSNP
rs1265160763 5828 dbSNP
rs10994521 5831 dbSNP
rs1477305693 5832 dbSNP
rs747593854 5832 dbSNP
rs1246498149 5833 dbSNP
rs529661077 5836 dbSNP
rs1396902156 5837 dbSNP
rs1216865121 5838 dbSNP
rs1449090809 5839 dbSNP
rs978383708 5845 dbSNP
rs1169957396 5846 dbSNP
rs935280367 5849 dbSNP
rs1463829989 5851 dbSNP
rs1292205778 5858 dbSNP
rs1394391354 5860 dbSNP
rs1442197003 5868 dbSNP
rs562012605 5884 dbSNP
rs1372478324 5891 dbSNP
rs1225594066 5904 dbSNP
rs1294373163 5905 dbSNP
rs1215411235 5913 dbSNP
rs924040791 5914 dbSNP
rs968671477 5918 dbSNP
rs6479731 5932 dbSNP
rs1263385780 5933 dbSNP
rs1467877466 5938 dbSNP
rs1214191726 5940 dbSNP
rs1012768433 5952 dbSNP
rs1232018767 5955 dbSNP
rs1463575048 5963 dbSNP
rs960122426 5965 dbSNP
rs544335508 5966 dbSNP
rs1430586379 5970 dbSNP
rs1432718236 5982 dbSNP
rs1324456430 5987 dbSNP
rs531889694 5989 dbSNP
rs1003583679 5997 dbSNP
rs911083034 6008 dbSNP
rs1387148071 6011 dbSNP
rs75907017 6013 dbSNP
rs1037003577 6018 dbSNP
rs1287844972 6020 dbSNP
rs1362223220 6024 dbSNP
rs1005938770 6026 dbSNP
rs748189892 6027 dbSNP
rs1333826398 6028 dbSNP
rs6479730 6030 dbSNP
rs1175548649 6033 dbSNP
rs1327064212 6038 dbSNP
rs560598470 6043 dbSNP
rs1242710324 6062 dbSNP
rs1413267148 6068 dbSNP
rs181559120 6082 dbSNP
rs1187598094 6086 dbSNP
rs10994518 6095 dbSNP
rs551317484 6104 dbSNP
rs367585181 6109 dbSNP
rs1190582091 6115 dbSNP
rs756492205 6124 dbSNP
rs934400212 6126 dbSNP
rs1485766563 6128 dbSNP
rs924322014 6135 dbSNP
rs978462954 6138 dbSNP
rs968764339 6142 dbSNP
rs1345214587 6143 dbSNP
rs1454919005 6144 dbSNP
rs750823071 6146 dbSNP
rs763717650 6153 dbSNP
rs537746681 6156 dbSNP
rs991799009 6165 dbSNP
rs762619660 6166 dbSNP
rs772875146 6168 dbSNP
rs1370911501 6174 dbSNP
rs1035492614 6177 dbSNP
rs1337253726 6182 dbSNP
rs1277292421 6192 dbSNP
rs1318768610 6198 dbSNP
rs1208874434 6204 dbSNP
rs1005281437 6206 dbSNP
rs993259282 6208 dbSNP
rs202159488 6221 dbSNP
rs575534345 6229 dbSNP
rs961456620 6231 dbSNP
rs1356257684 6232 dbSNP
rs1469964588 6242 dbSNP
rs1178237041 6244 dbSNP
rs772392502 6248 dbSNP
rs1410847634 6249 dbSNP
rs1015609606 6255 dbSNP
rs1445981373 6260 dbSNP
rs1012795876 6264 dbSNP
rs896737572 6271 dbSNP
rs1434879046 6273 dbSNP
rs1005575311 6287 dbSNP
rs1171777248 6295 dbSNP
rs774943715 6296 dbSNP
rs748258717 6299 dbSNP
rs1050044831 6301 dbSNP
rs1163933999 6302 dbSNP
rs774579520 6303 dbSNP
rs1441248127 6306 dbSNP
rs1421972595 6308 dbSNP
rs1375510754 6321 dbSNP
rs1232169938 6335 dbSNP
rs1302858928 6337 dbSNP
rs1056707940 6341 dbSNP
rs1213223257 6343 dbSNP
rs555560529 6346 dbSNP
rs1170328177 6359 dbSNP
rs1437573240 6361 dbSNP
rs997503798 6362 dbSNP
rs935334483 6366 dbSNP
rs901385765 6369 dbSNP
rs902547575 6378 dbSNP
rs1487829808 6410 dbSNP
rs1193561335 6424 dbSNP
rs1466125056 6426 dbSNP
rs1454352037 6432 dbSNP
rs535272422 6433 dbSNP
rs934785627 6437 dbSNP
rs768819475 6440 dbSNP
rs1329365574 6444 dbSNP
rs1356208420 6457 dbSNP
rs1438543248 6462 dbSNP
rs1482664971 6465 dbSNP
rs1232929080 6467 dbSNP
rs924374238 6480 dbSNP
rs1371764898 6482 dbSNP
rs116443150 6489 dbSNP
rs1268611891 6490 dbSNP
rs562365225 6505 dbSNP
rs1339043263 6513 dbSNP
rs1215517439 6521 dbSNP
rs947099400 6530 dbSNP
rs148571483 6531 dbSNP
rs1213563337 6539 dbSNP
rs991133168 6545 dbSNP
rs58457979 6549 dbSNP
rs1468514213 6551 dbSNP
rs938610912 6554 dbSNP
rs928528081 6560 dbSNP
rs1239994458 6569 dbSNP
rs1336673196 6584 dbSNP
rs1168143280 6590 dbSNP
rs1295394706 6592 dbSNP
rs1459704811 6594 dbSNP
rs1164088293 6602 dbSNP
rs1226801551 6608 dbSNP
rs1443175237 6609 dbSNP
rs1378563966 6616 dbSNP
rs971892350 6619 dbSNP
rs961834912 6620 dbSNP
rs1444995752 6633 dbSNP
rs1398667398 6635 dbSNP
rs546302494 6636 dbSNP
rs1333098177 6642 dbSNP
rs7084132 6646 dbSNP
rs567156102 6651 dbSNP
rs770840536 6657 dbSNP
rs909589927 6664 dbSNP
rs1162315452 6681 dbSNP
rs1281445576 6683 dbSNP
rs189174124 6687 dbSNP
rs187649536 6706 dbSNP
rs1264928403 6710 dbSNP
rs375211022 6719 dbSNP
rs200669187 6728 dbSNP
rs200016812 6729 dbSNP
rs1187028024 6735 dbSNP
rs1418476357 6741 dbSNP
rs1459317160 6749 dbSNP
rs901436511 6762 dbSNP
rs1384283259 6765 dbSNP
rs552782868 6774 dbSNP
rs1237568256 6775 dbSNP
rs1320498263 6778 dbSNP
rs999047025 6797 dbSNP
rs532777078 6807 dbSNP
rs1023099452 6815 dbSNP
rs1294364783 6820 dbSNP
rs903335631 6823 dbSNP
rs1237449677 6829 dbSNP
rs1263408463 6830 dbSNP
rs1012434734 6850 dbSNP
rs1042844867 6853 dbSNP
rs10994507 6855 dbSNP
rs1484522560 6859 dbSNP
rs1035175525 6869 dbSNP
rs1257891802 6871 dbSNP
rs1307813535 6876 dbSNP
rs1425357250 6878 dbSNP
rs866954139 6884 dbSNP
rs902766482 6887 dbSNP
rs1043784077 6888 dbSNP
rs760018751 6892 dbSNP
rs540732490 6893 dbSNP
rs1434270498 6899 dbSNP
rs1397167083 6905 dbSNP
rs1050241278 6906 dbSNP
rs1390063536 6907 dbSNP
rs1306884739 6910 dbSNP
rs934076395 6927 dbSNP
rs1239129457 6936 dbSNP
rs1310724281 6942 dbSNP
rs1345135351 6943 dbSNP
rs531249266 6945 dbSNP
rs772378986 6947 dbSNP
rs1484094053 6954 dbSNP
rs1193908290 6955 dbSNP
rs1345351751 6956 dbSNP
rs1160840315 6969 dbSNP
rs561116239 6980 dbSNP
rs1437326408 6983 dbSNP
rs1379132692 6985 dbSNP
rs1194211141 6992 dbSNP
rs1393287185 6992 dbSNP
rs909036936 6992 dbSNP
rs984601957 7009 dbSNP
rs544625843 7018 dbSNP
rs575423893 7023 dbSNP
rs1298028985 7028 dbSNP
rs975428378 7029 dbSNP
rs1397657901 7033 dbSNP
rs965351710 7044 dbSNP
rs909769868 7050 dbSNP
rs1219033027 7051 dbSNP
rs983755150 7052 dbSNP
rs558834175 7063 dbSNP
rs999097965 7068 dbSNP
rs1303663517 7073 dbSNP
rs1285335370 7075 dbSNP
rs993017717 7089 dbSNP
rs1224965918 7092 dbSNP
rs1250486057 7094 dbSNP
rs1339850596 7108 dbSNP
rs1200406414 7113 dbSNP
rs180848500 7115 dbSNP
rs903389313 7129 dbSNP
rs1299655798 7133 dbSNP
rs959801873 7136 dbSNP
rs1269726258 7139 dbSNP
rs1426890599 7143 dbSNP
rs1170020497 7154 dbSNP
rs1373944818 7157 dbSNP
rs1163364679 7158 dbSNP
rs1394457323 7164 dbSNP
rs572713240 7168 dbSNP
rs1290318737 7169 dbSNP
rs1011719673 7182 dbSNP
rs1293675650 7193 dbSNP
rs894236027 7197 dbSNP
rs61856570 7198 dbSNP
rs938379515 7201 dbSNP
rs966952813 7234 dbSNP
rs1294436664 7239 dbSNP
rs535942825 7241 dbSNP
rs1220284702 7246 dbSNP
rs1173643393 7247 dbSNP
rs906871015 7249 dbSNP
rs1022529142 7251 dbSNP
rs1267236873 7252 dbSNP
rs1484946064 7266 dbSNP
rs1375916990 7269 dbSNP
rs1186106932 7272 dbSNP
rs1262742680 7280 dbSNP
rs1036276362 7291 dbSNP
rs1186324702 7294 dbSNP
rs112429040 7296 dbSNP
rs1175265544 7304 dbSNP
rs1417769864 7309 dbSNP
rs1462364456 7313 dbSNP
rs1167545344 7320 dbSNP
rs940614763 7321 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccacaauucggaacgAGUCUCu 5'
                         |||||| 
Target 5' ---------------UCAGAGa 3'
 		1 - 7
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 29974.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 29974.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000374001.2 | 3UTR | UCAGAGAAUUCUCCUUUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000374001.2 | 3UTR | UCAGAGAAUUCUCCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000374001.2 | 3UTR | UCAGAGAAUUCUCCUUUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000374001.2 | 3UTR | UCAGAGAAUUCUCCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000374001.2 | 3UTR | CAGAGAAUUCUCCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
78 hsa-miR-4653-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118186 ZNF544 zinc finger protein 544 2 2
MIRT332935 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442166 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442387 CLVS2 clavesin 2 2 2
MIRT442595 SIX1 SIX homeobox 1 2 2
MIRT448014 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448061 MMP15 matrix metallopeptidase 15 2 2
MIRT489017 C1QTNF6 C1q and TNF related 6 2 2
MIRT494456 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495650 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504016 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506777 KLHL15 kelch like family member 15 2 4
MIRT507229 FOXN2 forkhead box N2 2 4
MIRT512550 MFN2 mitofusin 2 2 6
MIRT512842 A1CF APOBEC1 complementation factor 2 6
MIRT513944 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516103 GADL1 glutamate decarboxylase like 1 2 4
MIRT519831 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523210 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525008 ACTN4 actinin alpha 4 2 6
MIRT528858 PKP1 plakophilin 1 2 2
MIRT529062 ZNF675 zinc finger protein 675 2 2
MIRT531719 TARS threonyl-tRNA synthetase 2 2
MIRT534039 STK4 serine/threonine kinase 4 2 2
MIRT543848 APIP APAF1 interacting protein 2 2
MIRT545866 ZNF264 zinc finger protein 264 2 4
MIRT556037 MXD1 MAX dimerization protein 1 2 2
MIRT557081 HOXB3 homeobox B3 2 2
MIRT561345 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562705 ZNF415 zinc finger protein 415 2 2
MIRT563223 ZNF286A zinc finger protein 286A 2 2
MIRT563860 ZNF616 zinc finger protein 616 2 4
MIRT563879 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564652 ZNF487P zinc finger protein 487 1 1
MIRT566595 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570878 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573067 TRIB1 tribbles pseudokinase 1 2 2
MIRT573941 ZNF708 zinc finger protein 708 2 2
MIRT575966 Slfn5 schlafen 5 2 5
MIRT607293 CD300E CD300e molecule 2 4
MIRT608187 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609537 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610152 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611571 SLFN5 schlafen family member 5 2 7
MIRT613335 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616560 ZNF512B zinc finger protein 512B 2 2
MIRT617240 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618011 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618478 IL17REL interleukin 17 receptor E like 2 2
MIRT619099 IFI44L interferon induced protein 44 like 2 2
MIRT622265 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623080 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625621 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627844 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630459 GMPS guanine monophosphate synthase 2 2
MIRT630524 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631502 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634537 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638807 DCTN3 dynactin subunit 3 2 2
MIRT641303 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648347 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649705 ZNF175 zinc finger protein 175 2 2
MIRT652554 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655564 P2RX7 purinergic receptor P2X 7 2 2
MIRT659065 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660341 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664330 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688934 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689971 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699514 SKIL SKI like proto-oncogene 2 2
MIRT699975 RREB1 ras responsive element binding protein 1 2 2
MIRT702676 IRS2 insulin receptor substrate 2 2 2
MIRT709357 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709837 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718716 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718879 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724105 TMEM199 transmembrane protein 199 2 2
MIRT724763 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4653-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)

Error report submission