pre-miRNA Information | |
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pre-miRNA | hsa-mir-4763 |
Genomic Coordinates | chr22: 46113566 - 46113657 |
Description | Homo sapiens miR-4763 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-4763-5p | |||||||||||||||||||||||||||||||||
Sequence | 19| CGCCUGCCCAGCCCUCCUGCU |39 | |||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | MKI67 | ||||||||||||||||||||
Synonyms | KIA, MIB-, MIB-1, PPP1R105 | ||||||||||||||||||||
Description | marker of proliferation Ki-67 | ||||||||||||||||||||
Transcript | NM_001145966 | ||||||||||||||||||||
Other Transcripts | NM_002417 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on MKI67 | |||||||||||||||||||||
3'UTR of MKI67 (miRNA target sites are highlighted) |
>MKI67|NM_001145966|3'UTR 1 CAGAAAAATCGAACTGGGAAAAATATAATAAAGTTAGTTTTGTGATAAGTTCTAGTGCAGTTTTTGTCATAAATTACAAG 81 TGAATTCTGTAAGTAAGGCTGTCAGTCTGCTTAAGGGAAGAAAACTTTGGATTTGCTGGGTCTGAATCGGCTTCATAAAC 161 TCCACTGGGAGCACTGCTGGGCTCCTGGACTGAGAATAGTTGAACACCGGGGGCTTTGTGAAGGAGTCTGGGCCAAGGTT 241 TGCCCTCAGCTTTGCAGAATGAAGCCTTGAGGTCTGTCACCACCCACAGCCACCCTACAGCAGCCTTAACTGTGACACTT 321 GCCACACTGTGTCGTCGTTTGTTTGCCTATGTCCTCCAGGGCACGGTGGCAGGAACAACTATCCTCGTCTGTCCCAACAC 401 TGAGCAGGCACTCGGTAAACACGAATGAATGGATGAGCGCACGGATGAATGGAGCTTACAAGATCTGTCTTTCCAATGGC 481 CGGGGGCATTTGGTCCCCAAATTAAGGCTATTGGACATCTGCACAGGACAGTCCTATTTTTGATGTCCTTTCCTTTCTGA 561 AAATAAAGTTTTGTGCTTTGGAGAATGACTCGTGAGCACATCTTTAGGGACCAAGAGTGACTTTCTGTAAGGAGTGACTC 641 GTGGCTTGCCTTGGTCTCTTGGGAATACTTTTCTAACTAGGGTTGCTCTCACCTGAGACATTCTCCACCCGCGGAATCTC 721 AGGGTCCCAGGCTGTGGGCCATCACGACCTCAAACTGGCTCCTAATCTCCAGCTTTCCTGTCATTGAAAGCTTCGGAAGT 801 TTACTGGCTCTGCTCCCGCCTGTTTTCTTTCTGACTCTATCTGGCAGCCCGATGCCACCCAGTACAGGAAGTGACACCAG 881 TACTCTGTAAAGCATCATCATCCTTGGAGAGACTGAGCACTCAGCACCTTCAGCCACGATTTCAGGATCGCTTCCTTGTG 961 AGCCGCTGCCTCCGAAATCTCCTTTGAAGCCCAGACATCTTTCTCCAGCTTCAGACTTGTAGATATAACTCGTTCATCTT 1041 CATTTACTTTCCACTTTGCCCCCTGTCCTCTCTGTGTTCCCCAAATCAGAGAATAGCCCGCCATCCCCCAGGTCACCTGT 1121 CTGGATTCCTCCCCATTCACCCACCTTGCCAGGTGCAGGTGAGGATGGTGCACCAGACAGGGTAGCTGTCCCCCAAAATG 1201 TGCCCTGTGCGGGCAGTGCCCTGTCTCCACGTTTGTTTCCCCAGTGTCTGGCGGGGAGCCAGGTGACATCATAAATACTT 1281 GCTGAATGAATGCAGAAATCAGCGGTACTGACTTGTACTATATTGGCTGCCATGATAGGGTTCTCACAGCGTCATCCATG 1361 ATCGTAAGGGAGAATGACATTCTGCTTGAGGGAGGGAATAGAAAGGGGCAGGGAGGGGACATCTGAGGGCTTCACAGGGC 1441 TGCAAAGGGTACAGGGATTGCACCAGGGCAGAACAGGGGAGGGTGTTCAAGGAAGAGTGGCTCTTAGCAGAGGCACTTTG 1521 GAAGGTGTGAGGCATAAATGCTTCCTTCTACGTAGGCCAACCTCAAAACTTTCAGTAGGAATGTTGCTATGATCAAGTTG 1601 TTCTAACACTTTAGACTTAGTAGTAATTATGAACCTCACATAGAAAAATTTCATCCAGCCATATGCCTGTGGAGTGGAAT 1681 ATTCTGTTTAGTAGAAAAATCCTTTAGAGTTCAGCTCTAACCAGAAATCTTGCTGAAGTATGTCAGCACCTTTTCTCACC 1761 CTGGTAAGTACAGTATTTCAAGAGCACGCTAAGGGTGGTTTTCATTTTACAGGGCTGTTGATGATGGGTTAAAAATGTTC 1841 ATTTAAGGGCTACCCCCGTGTTTAATAGATGAACACCACTTCTACACAACCCTCCTTGGTACTGGGGGAGGGAGAGATCT 1921 GACAAATACTGCCCATTCCCCTAGGCTGACTGGATTTGAGAACAAATACCCACCCATTTCCACCATGGTATGGTAACTTC 2001 TCTGAGCTTCAGTTTCCAAGTGAATTTCCATGTAATAGGACATTCCCATTAAATACAAGCTGTTTTTACTTTTTCGCCTC 2081 CCAGGGCCTGTGGGATCTGGTCCCCCAGCCTCTCTTGGGCTTTCTTACACTAACTCTGTACCTACCATCTCCTGCCTCCC 2161 TTAGGCAGGCACCTCCAACCACCACACACTCCCTGCTGTTTTCCCTGCCTGGAACTTTCCCTCCTGCCCCACCAAGATCA 2241 TTTCATCCAGTCCTGAGCTCAGCTTAAGGGAGGCTTCTTGCCTGTGGGTTCCCTCACCCCCATGCCTGTCCTCCAGGCTG 2321 GGGCAGGTTCTTAGTTTGCCTGGAATTGTTCTGTACCTCTTTGTAGCACGTAGTGTTGTGGAAACTAAGCCACTAATTGA 2401 GTTTCTGGCTCCCCTCCTGGGGTTGTAAGTTTTGTTCATTCATGAGGGCCGACTGCATTTCCTGGTTACTCTATCCCAGT 2481 GACCAGCCACAGGAGATGTCCAATAAAGTATGTGATGAAATGGTCTTAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 4288.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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CLIP-seq Support 1 for dataset GSM4903831 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Human neurons / 124TD_shELAVL3_a |
Location of target site | NM_001145966 | 3UTR | CUCCCUUAGGCAGGCA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161238 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1065668 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_7 |
Location of target site | ENST00000368653.3 | 3UTR | GCACUCGGUAAACACGAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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69 hsa-miR-4763-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT116035 | DEPDC1 | DEP domain containing 1 | 2 | 2 | ||||||||
MIRT347197 | SIN3B | SIN3 transcription regulator family member B | 2 | 2 | ||||||||
MIRT443248 | C9orf170 | chromosome 9 open reading frame 170 | 2 | 2 | ||||||||
MIRT475164 | IP6K1 | inositol hexakisphosphate kinase 1 | 2 | 2 | ||||||||
MIRT495486 | VTI1B | vesicle transport through interaction with t-SNAREs 1B | 2 | 2 | ||||||||
MIRT496755 | TGIF2 | TGFB induced factor homeobox 2 | 2 | 2 | ||||||||
MIRT496863 | C21orf2 | chromosome 21 open reading frame 2 | 2 | 2 | ||||||||
MIRT499264 | NBPF11 | NBPF member 11 | 2 | 2 | ||||||||
MIRT499517 | MAFK | MAF bZIP transcription factor K | 2 | 2 | ||||||||
MIRT512952 | MKI67 | marker of proliferation Ki-67 | 2 | 2 | ||||||||
MIRT514656 | NUP93 | nucleoporin 93 | 2 | 2 | ||||||||
MIRT517986 | SLC16A13 | solute carrier family 16 member 13 | 2 | 2 | ||||||||
MIRT522816 | KLHL9 | kelch like family member 9 | 2 | 4 | ||||||||
MIRT525495 | CD63 | CD63 molecule | 2 | 2 | ||||||||
MIRT528111 | FOXH1 | forkhead box H1 | 2 | 2 | ||||||||
MIRT531683 | MYO3A | myosin IIIA | 2 | 2 | ||||||||
MIRT534806 | RAB37 | RAB37, member RAS oncogene family | 2 | 2 | ||||||||
MIRT573041 | SHMT1 | serine hydroxymethyltransferase 1 | 2 | 2 | ||||||||
MIRT576720 | Wars | tryptophanyl-tRNA synthetase | 2 | 2 | ||||||||
MIRT609727 | MLXIPL | MLX interacting protein like | 2 | 2 | ||||||||
MIRT610843 | FAM180B | family with sequence similarity 180 member B | 2 | 4 | ||||||||
MIRT614735 | STAT5A | signal transducer and activator of transcription 5A | 2 | 2 | ||||||||
MIRT616981 | EPOR | erythropoietin receptor | 2 | 2 | ||||||||
MIRT617265 | MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2 | 2 | ||||||||
MIRT619405 | INTS7 | integrator complex subunit 7 | 2 | 2 | ||||||||
MIRT621832 | TIMM8A | translocase of inner mitochondrial membrane 8A | 2 | 2 | ||||||||
MIRT621893 | TAF13 | TATA-box binding protein associated factor 13 | 2 | 2 | ||||||||
MIRT630263 | SMIM14 | small integral membrane protein 14 | 2 | 2 | ||||||||
MIRT634879 | SENP8 | SUMO/sentrin peptidase family member, NEDD8 specific | 2 | 2 | ||||||||
MIRT636863 | ARSE | arylsulfatase E (chondrodysplasia punctata 1) | 2 | 2 | ||||||||
MIRT637653 | ADAT1 | adenosine deaminase, tRNA specific 1 | 2 | 2 | ||||||||
MIRT637699 | ZNF439 | zinc finger protein 439 | 2 | 2 | ||||||||
MIRT637759 | GATAD1 | GATA zinc finger domain containing 1 | 2 | 2 | ||||||||
MIRT638193 | TAOK1 | TAO kinase 1 | 2 | 2 | ||||||||
MIRT638996 | ADO | 2-aminoethanethiol dioxygenase | 2 | 2 | ||||||||
MIRT642221 | RABAC1 | Rab acceptor 1 | 2 | 2 | ||||||||
MIRT643327 | ATCAY | ATCAY, caytaxin | 2 | 4 | ||||||||
MIRT643419 | ERVMER34-1 | endogenous retrovirus group MER34 member 1, envelope | 2 | 2 | ||||||||
MIRT644499 | RNF14 | ring finger protein 14 | 2 | 2 | ||||||||
MIRT644603 | NT5DC3 | 5'-nucleotidase domain containing 3 | 2 | 2 | ||||||||
MIRT644795 | C21orf59 | chromosome 21 open reading frame 59 | 2 | 2 | ||||||||
MIRT648732 | HIST1H2BD | histone cluster 1 H2B family member d | 2 | 2 | ||||||||
MIRT653856 | SHE | Src homology 2 domain containing E | 2 | 2 | ||||||||
MIRT654129 | RPL14 | ribosomal protein L14 | 2 | 4 | ||||||||
MIRT658876 | DSN1 | DSN1 homolog, MIS12 kinetochore complex component | 2 | 2 | ||||||||
MIRT671624 | C20orf144 | chromosome 20 open reading frame 144 | 2 | 4 | ||||||||
MIRT677367 | HSPA4L | heat shock protein family A (Hsp70) member 4 like | 2 | 2 | ||||||||
MIRT677579 | TRIM65 | tripartite motif containing 65 | 2 | 2 | ||||||||
MIRT678220 | MACC1 | MACC1, MET transcriptional regulator | 2 | 2 | ||||||||
MIRT679613 | RRP36 | ribosomal RNA processing 36 | 2 | 2 | ||||||||
MIRT686081 | PNPLA3 | patatin like phospholipase domain containing 3 | 2 | 2 | ||||||||
MIRT691817 | ICA1L | islet cell autoantigen 1 like | 2 | 2 | ||||||||
MIRT693869 | COX19 | COX19, cytochrome c oxidase assembly factor | 2 | 2 | ||||||||
MIRT694544 | BPNT1 | 3'(2'), 5'-bisphosphate nucleotidase 1 | 2 | 2 | ||||||||
MIRT694926 | ANKS4B | ankyrin repeat and sterile alpha motif domain containing 4B | 2 | 2 | ||||||||
MIRT697758 | USP37 | ubiquitin specific peptidase 37 | 2 | 2 | ||||||||
MIRT697891 | UBE2B | ubiquitin conjugating enzyme E2 B | 2 | 2 | ||||||||
MIRT701569 | MYPN | myopalladin | 2 | 2 | ||||||||
MIRT703081 | GPRIN3 | GPRIN family member 3 | 2 | 2 | ||||||||
MIRT708104 | IGF2BP1 | insulin like growth factor 2 mRNA binding protein 1 | 2 | 2 | ||||||||
MIRT708320 | NT5C | 5', 3'-nucleotidase, cytosolic | 2 | 2 | ||||||||
MIRT709878 | TRAF1 | TNF receptor associated factor 1 | 2 | 2 | ||||||||
MIRT713545 | GJB1 | gap junction protein beta 1 | 2 | 2 | ||||||||
MIRT716275 | NUP85 | nucleoporin 85 | 2 | 2 | ||||||||
MIRT716621 | CRCP | CGRP receptor component | 2 | 2 | ||||||||
MIRT717987 | C9orf171 | cilia and flagella associated protein 77 | 2 | 2 | ||||||||
MIRT718438 | RAB11B | RAB11B, member RAS oncogene family | 2 | 2 | ||||||||
MIRT722544 | AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 2 | 2 | ||||||||
MIRT724013 | F2RL1 | F2R like trypsin receptor 1 | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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