>BRIX1|NM_018321|3'UTR
   1 GTCAATGGAAACCTGATTTGTTTTTCAGTTACTTTATATTTATTTTGTATTCAATGTGTAAATACTTTTATTATCTAATA
  81 CTATCTTACGTCTAATTAGTGTAGCATTTACAAGAAAGAAAAATTAAGATCTTAAAATCAGTGATTATCTTTTTCTAAAT
 161 AAAATATCACCAGAATTCATCAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Mutant ID	Mutant Position	Mutant Source
COSN26968085	18	COSMIC
COSN30155636	53	COSMIC
COSN9433774	420	COSMIC

Mutant ID	Mutant Position	Mutant Source
rs374881575	6	dbSNP
rs755492270	7	dbSNP
rs781718839	14	dbSNP
rs1351127237	17	dbSNP
rs1428020866	19	dbSNP
rs753039316	20	dbSNP
rs763647074	21	dbSNP
rs1331822768	27	dbSNP
rs776316078	33	dbSNP
rs999278355	36	dbSNP
rs760556018	37	dbSNP
rs1448192854	38	dbSNP
rs1274263218	39	dbSNP
rs778062020	47	dbSNP
rs749542734	50	dbSNP
rs1311655915	54	dbSNP
rs572215432	58	dbSNP
rs1240670119	61	dbSNP
rs1184287333	75	dbSNP
rs1266633231	75	dbSNP
rs1328862870	80	dbSNP
rs1272346661	88	dbSNP
rs763753384	90	dbSNP
rs1017769705	91	dbSNP
rs1339963423	93	dbSNP
rs1265516079	111	dbSNP
rs1378217356	115	dbSNP
rs184068732	125	dbSNP
rs900011254	133	dbSNP
rs375971413	138	dbSNP
rs976334995	140	dbSNP
rs1029936181	141	dbSNP
rs950390662	144	dbSNP
rs760205107	146	dbSNP
rs1251582525	150	dbSNP
rs1306870131	152	dbSNP
rs768288357	160	dbSNP
rs27966	162	dbSNP
rs1421117376	170	dbSNP
rs1367942627	173	dbSNP
rs1164795984	177	dbSNP
rs1456605190	180	dbSNP
rs996990357	184	dbSNP
rs1179366954	197	dbSNP
rs1470626136	205	dbSNP
rs983536568	212	dbSNP
rs1251444983	224	dbSNP
rs908927887	230	dbSNP
rs1490863522	237	dbSNP
rs1270915675	240	dbSNP
rs1223100709	250	dbSNP
rs1180243435	251	dbSNP
rs891381140	256	dbSNP
rs941777778	258	dbSNP
rs990644292	262	dbSNP
rs753546788	267	dbSNP
rs1287339304	285	dbSNP
rs1177117954	292	dbSNP
rs1360826235	293	dbSNP
rs1407400872	297	dbSNP
rs560235847	302	dbSNP
rs1004248656	305	dbSNP
rs1464156865	317	dbSNP
rs141986142	318	dbSNP
rs555090949	334	dbSNP
rs1015587933	336	dbSNP
rs1436361506	340	dbSNP
rs949264149	343	dbSNP
rs542652030	344	dbSNP
rs563035383	351	dbSNP
rs1401653740	354	dbSNP
rs1411432063	359	dbSNP
rs1396509626	374	dbSNP
rs1157242348	375	dbSNP
rs1392802928	376	dbSNP
rs1286018826	378	dbSNP
rs188626415	382	dbSNP
rs1190746150	384	dbSNP
rs1488115981	385	dbSNP
rs1212745037	388	dbSNP
rs1217610167	392	dbSNP
rs1465201167	415	dbSNP
rs574825078	416	dbSNP
rs1226154957	418	dbSNP
rs1283350676	424	dbSNP
rs1325305787	424	dbSNP
rs1218197335	425	dbSNP
rs1366021994	429	dbSNP
rs531559487	445	dbSNP
rs1350305101	449	dbSNP
rs1291153067	450	dbSNP
rs1224471671	455	dbSNP
rs923866702	468	dbSNP
rs150400177	469	dbSNP
rs1209954185	476	dbSNP
rs764731312	484	dbSNP
rs1251967763	489	dbSNP
rs1175369061	499	dbSNP

- Nature, 2013

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.